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  1. Cancer related thrombosis not only increases morbidity and mortality but also poses a significant financial burden on health care system. Risk of venous thromboembolism (VTE) in these patients substantially in...

    Authors: Muhammad Nauman Zahir, Quratulain Shaikh, Munira Shabbir-Moosajee and Adnan Abdul Jabbar
    Citation: BMC Cancer 2017 17:57
    Content type: Research article Published on:

  2. Fibrinogen (FIB) is an important source of fibrin, which plays a crucial role in circulating tumor cells (CTCs) extravasation and distant metastasis development. We hypothesize it’s stable final product, plasm...

    Authors: Dongmei Diao, Yao Cheng, Yongchun Song, Hao Zhang, Zhangjian Zhou and Chengxue Dang
    Citation: BMC Cancer 2017 17:56
    Content type: Research article Published on:

  3. Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated in current study.

    Authors: Peiju Qiu, Siwen Wang, Ming Liu, He Ma, Xuan Zeng, Meng Zhang, Lingling Xu, Yidi Cui, Huixin Xu, Yang Tang, Yanli He and Lijuan Zhang
    Citation: BMC Cancer 2017 17:55
    Content type: Research article Published on:

  4. In the early stage esophageal cancer, changes in the mucosa are subtle and pass unnoticed in endoscopic examinations using white light. To increase sensitivity, chromoscopy with Lugol’s solution has been used....

    Authors: Flavio Hiroshi Ananias Morita, Wanderley Marques Bernardo, Edson Ide, Rodrigo Silva Paula Rocha, Julio Cesar Martins Aquino, Mauricio Kazuyoshi Minata, Kendi Yamazaki, Sergio Barbosa Marques, Paulo Sakai and Eduardo Guimarães Hourneaux de Moura
    Citation: BMC Cancer 2017 17:54
    Content type: Research article Published on:

  5. Detection of circulating (CTC) or disseminated tumor cells (DTC) has been associated with negative prognosis and outcome in patients with colorectal cancer, though testing for these cells is not yet part of cl...

    Authors: Sebastian Hinz, Alexander Hendricks, Amke Wittig, Clemens Schafmayer, Jürgen Tepel, Holger Kalthoff, Thomas Becker and Christian Röder
    Citation: BMC Cancer 2017 17:53
    Content type: Research article Published on:

  6. The basic helix-loop-helix transcription factor TWIST1 (Twist) is involved in embryonic cell lineage determination and mesodermal differentiation. There is evidence to indicate that Twist expression plays a ro...

    Authors: Farhad Vesuna, Yehudit Bergman and Venu Raman
    Citation: BMC Cancer 2017 17:52
    Content type: Research article Published on:

  7. Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promisi...

    Authors: Maria Laura Pati, John R. Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer, Carmen Abate and William Hawkins
    Citation: BMC Cancer 2017 17:51
    Content type: Research article Published on:

  8. Delta like 4 (Dll4)/Notch signaling is a key regulator of tumor angiogenesis. Additionally, the role of Dll4 has been studied on tumor stem cells. However, as these cells are implicated in tumor angiogenesis, ...

    Authors: Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luís Lopes-da-Costa and António Duarte
    Citation: BMC Cancer 2017 17:50
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:205

  9. Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of...

    Authors: Vijayalakshmi N. Ayyagari, Tsung-han Jeff Hsieh, Paula L. Diaz-Sylvester and Laurent Brard
    Citation: BMC Cancer 2017 17:49
    Content type: Research article Published on:

  10. No biomarker exists to guide the optimal choice of chemotherapy for patients with metastatic colorectal cancer. We examined the copy numbers (CN) of topoisomerase I (TOP1) as well as the ratios of TOP1/CEN-20 and...

    Authors: Jesper Andreas Palshof, Estrid Vilma Solyom Høgdall, Tim Svenstrup Poulsen, Dorte Linnemann, Benny Vittrup Jensen, Per Pfeiffer, Line Schmidt Tarpgaard, Nils Brünner, Jan Stenvang, Mette Yilmaz and Dorte Lisbet Nielsen
    Citation: BMC Cancer 2017 17:48
    Content type: Research article Published on:

  11. The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of t...

    Authors: Émilie Marrer, Damien Jolly, Patrick Arveux, Catherine Lejeune, Marie-Christine Woronoff-Lemsi, Jérémie Jégu, Francis Guillemin and Michel Velten
    Citation: BMC Cancer 2017 17:47
    Content type: Research article Published on:

  12. Gastric cancer is the second leading cause of cancer globally, and the mechanism of its pathogenesis is still largely unknown. Recently, non-coding RNAs have been recognized to promote metastasis in various ca...

    Authors: Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan Hyuk Park, George A. Calin and Sang Kil Lee
    Citation: BMC Cancer 2017 17:46
    Content type: Research article Published on:

  14. BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA b...

    Authors: Simone Brandt, Eleftherios P. Samartzis, Anne-Katrin Zimmermann, Daniel Fink, Holger Moch, Aurelia Noske and Konstantin J. Dedes
    Citation: BMC Cancer 2017 17:44
    Content type: Research article Published on:

  15. Dysphagia is a significant side-effect following treatment for head and neck cancers, yet poor adherence to swallowing exercises is frequently reported in intervention studies. Behaviour change techniques (BCT...

    Authors: Roganie Govender, Christina H. Smith, Stuart A. Taylor, Helen Barratt and Benjamin Gardner
    Citation: BMC Cancer 2017 17:43
    Content type: Research article Published on:

  16. Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). The efficacy and roles of combining temozolomide (TMZ) with whole brain radiotherapy (WBRT) in protection neurocognitiv...

    Authors: Xia Deng, Zhen Zheng, Baochai Lin, Huafang Su, Hanbin Chen, Shaoran Fei, Zhenghua Fei, Lihao Zhao, Xiance Jin and Cong-Ying Xie
    Citation: BMC Cancer 2017 17:42
    Content type: Research article Published on:

  17. Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk...

    Authors: Parisa Tehranifar, Barbara A. Cohn, Julie D. Flom, Angeline Protacio, Piera Cirillo, L. H. Lumey, Karin B. Michels and Mary Beth Terry
    Citation: BMC Cancer 2017 17:41
    Content type: Research article Published on:

  18. Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in ...

    Authors: Xiaoyan Han, Lijuan Wang, Hongfei Shi, Gaofeng Zheng, Jingsong He, Wenjun Wu, Jimin Shi, Guoqing Wei, Weiyan Zheng, Jie Sun, He Huang and Zhen Cai
    Citation: BMC Cancer 2017 17:40
    Content type: Research article Published on:

  19. Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand the mechanism by which ...

    Authors: Noboru Nakaigawa, Keiichi Kondo, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Kazuki Kobayashi, Koichi Shioi, Ichiro Ikeda, Takeshi Kishida, Tomohiro Kaneta, Ryogo Minamimoto, Ukihide Tateishi, Tomio Inoue and Masahiro Yao
    Citation: BMC Cancer 2017 17:39
    Content type: Research article Published on:

  20. After analysis of minor RAS mutations (KRAS exon 3, 4/NRAS) in the FIRE-3 and PRIME studies, an expanded range of RAS mutations were established as a negative predictive marker for the efficacy of anti-EGFR antib...

    Authors: Izuma Nakayama, Eiji Shinozaki, Tomohiro Matsushima, Takeru Wakatsuki, Mariko Ogura, Takashi Ichimura, Masato Ozaka, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin, Nobuyuki Mizunuma and Kensei Yamaguchi
    Citation: BMC Cancer 2017 17:38
    Content type: Research article Published on:

  21. Long-term term survival in patients with pancreatic neuroendocrine tumors has been reported, even in patients with metastatic disease. Metastases to the spleen are extremely rare, but have been reported from a...

    Authors: Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno and Alan Kawarai Lefor
    Citation: BMC Cancer 2017 17:37
    Content type: Case report Published on:

  22. PIK3CA mutations are expected to be potential therapeutic targets for esophageal squamous cell carcinoma (ESCC). We aimed to clarify the concordance between PIK3CA mutations detected i...

    Authors: Ken Hatogai, Satoshi Fujii, Takashi Kojima, Hiroyuki Daiko, Toshihiko Doi, Atsushi Ohtsu, Atsushi Ochiai, Yuichi Takiguchi and Takayuki Yoshino
    Citation: BMC Cancer 2017 17:36
    Content type: Research article Published on:

  23. Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). S...

    Authors: Heather L. Stevenson, Mariana M. Prats and Eizaburo Sasatomi
    Citation: BMC Cancer 2017 17:35
    Content type: Research article Published on:

  24. Cryptotanshinone (CPT), a fat-soluble phenanthraquinone from Salvia miltiorrhiza Bunge, has been demonstrated to inhibit phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding prote...

    Authors: Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Wenting Ni, Aiyun Wang and Yin Lu
    Citation: BMC Cancer 2017 17:34
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:257

  25. Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological roles such as...

    Authors: Kengo Kuroda, Tomokazu Fukuda, Marija Krstic-Demonacos, Constantinos Demonacos, Kazuhiko Okumura, Hiroshi Isogai, Miwa Hayashi, Kazuki Saito and Emiko Isogai
    Citation: BMC Cancer 2017 17:33
    Content type: Research article Published on:

  26. The quantitative analysis of microRNA (miRNA) gene expression in archived formalin-fixed, paraffin embedded (FFPE) tissues has been instrumental to identifying their potential roles in cancer biology, diagnosi...

    Authors: Sarah B. Peskoe, John R. Barber, Qizhi Zheng, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz and Shawn E. Lupold
    Citation: BMC Cancer 2017 17:32
    Content type: Research article Published on:

  27. Multiple studies have reported evidence of an inverse association between parity and bladder cancer risk. However, a comprehensive and quantitative assessment of this association has never been conducted. We c...

    Authors: Yunjin Bai, Xiaoming Wang, Yubo Yang, Yin Tang, Jia Wang and Ping Han
    Citation: BMC Cancer 2017 17:31
    Content type: Research article Published on:

  28. This matched-pair study was initiated to validate the results of a retrospective study of 186 patients published in 2007 that compared whole-brain irradiation (WBI) alone and radiosurgery (RS) alone for up to ...

    Authors: Dirk Rades, Stefan Janssen, Liesa Dziggel, Oliver Blanck, Amira Bajrovic, Theo Veninga and Steven E. Schild
    Citation: BMC Cancer 2017 17:30
    Content type: Research article Published on:

  29. Many patients experience local recurrence or metastases after receiving potentially curative treatment, and early detection of these events is important for disease control. Recent technological advances make ...

    Authors: Heidi M. Namløs, Olga Zaikova, Bodil Bjerkehagen, Daniel Vodák, Eivind Hovig, Ola Myklebost, Kjetil Boye and Leonardo A. Meza-Zepeda
    Citation: BMC Cancer 2017 17:29
    Content type: Case report Published on:

  30. This study evaluated the distribution pattern of the Ki67-labeling index (LI) among patients at a Chinese breast cancer center, and analyzed its prognostic significance in the 2015 St Gallen consensus breast c...

    Authors: Yue Hu, Ran Gu, Jinghua Zhao, Yaping Yang, Fengtao Liu, Liang Jin, Kai Chen, Haixia Jia, Hongli Wang, Qiang Liu, Fengxi Su and Weijuan Jia
    Citation: BMC Cancer 2017 17:28
    Content type: Research article Published on:

  31. Metabolic toxicities of mTOR inhibitors (mTORi) are well characterized. The purpose of the study was to investigate the relationship between these metabolic toxicities and mTORi efficacy.

    Authors: M. Jebali, R. Elaidi, M. Brizard, J. Fouque, C. Takouchop, B. Sabatier, S. Oudard and J. Medioni
    Citation: BMC Cancer 2017 17:27
    Content type: Research article Published on:

  33. The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed ...

    Authors: Yuanyuan Xiao, Wen Chen, Zhihui Xie, Zhenyi Shao, Hua Xie, Guoyou Qin and Naiqing Zhao
    Citation: BMC Cancer 2017 17:25
    Content type: Research article Published on:

  34. Human chromosomes are capped and stabilized by telomeres. Telomere length regulates a ‘cellular mitotic clock’ that defines the number of cell divisions and hence, cellular life span. This study aimed to synth...

    Authors: Cho Naing, Kyan Aung, Pei Kuan Lai and Joon Wah Mak
    Citation: BMC Cancer 2017 17:24
    Content type: Research article Published on:

  35. The clinical prognosis of gastric cancer with peritoneal dissemination is poor because of its chemoresistance and rich fibrosis. While several gastric cancer cell lines have been used to establish models of pe...

    Authors: Mitsuyoshi Okazaki, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Itasu Ninomiya and Tetsuo Ohta
    Citation: BMC Cancer 2017 17:23
    Content type: Research article Published on:

  36. Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels ...

    Authors: Shouichi Okamoto, Shinsaku Togo, Ichiro Nagata, Kazue Shimizu, Yoshika Koinuma, Yukiko Namba, Jun Ito, Toshimasa Uekusa and Kazuhisa Takahashi
    Citation: BMC Cancer 2017 17:22
    Content type: Case report Published on:

  37. CD105 was postulated as a renal cell carcinoma (RCC) stem cell marker, and CD133 as a putative RCC progenitor. Hypoxia, a natural microenvironment that prevails in tumors, was also incorporated into the study,...

    Authors: Damian Matak, Klaudia K. Brodaczewska, Cezary Szczylik, Irena Koch, Adam Myszczyszyn, Monika Lipiec, Slawomir Lewicki, Lukasz Szymanski, Robert Zdanowski and Anna M. Czarnecka
    Citation: BMC Cancer 2017 17:21
    Content type: Research article Published on:

  39. One of the hallmarks of cancer is an altered energy metabolism, and here, mitochondria play a central role. Previous studies have indicated that some mitochondrial ribosomal proteins change their expression pa...

    Authors: Karen Marie Juul Sørensen, Theresa Meldgaard, Connie Jenning Melchjorsen, Agla J. Fridriksdottir, Henrik Pedersen, Ole William Petersen and Peter Kristensen
    Citation: BMC Cancer 2017 17:19
    Content type: Research article Published on:

  40. In endemic area, nasopharyngeal carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and a...

    Authors: Mei-Chun Lin, Yong-Chong Lin, Syue-Ting Chen, Tai-Horng Young and Pei-Jen Lou
    Citation: BMC Cancer 2017 17:18
    Content type: Research article Published on:

  41. Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many time...

    Authors: Leah Zhrebker, Irene Cherni, Lara M. Gross, Margaret M. Hinshelwood, Merrick Reese, Jessica Aldrich, Joseph M. Guileyardo, William C. Roberts, David Craig, Daniel D. Von Hoff, Robert G. Mennel and John D. Carpten
    Citation: BMC Cancer 2017 17:17
    Content type: Case report Published on:

  42. To compare the efficacy of sorafenib and sunitinib with regard to overall survival (OS) and progression free survival (PFS) in Chinese patients with metastatic renal cell carcinoma (mRCC).

    Authors: Hai-Liang Zhang, Xi-Nan Sheng, Xue-Song Li, Hong-Kai Wang, Zhi-Hong Chi, Zhi-Song He, Ding-Wei Ye and Jun Guo
    Citation: BMC Cancer 2017 17:16
    Content type: Research article Published on:

  43. Primary natural killer (NK)/T cell lymphoma of adrenal glands is an extremely rare tumor with aggressive clinical behavior. There have only been a few cases reported worldwide and the highest reported survival...

    Authors: Liu Hu, Weimin Xu, Mingwei Wang, Pan Wang, Guang Han and Chi Lin
    Citation: BMC Cancer 2017 17:15
    Content type: Case report Published on:

  44. The Hangzhou criteria expand the Milan criteria safely and effectively in selecting hepatocellular carcinoma (HCC) candidates for liver transplantation (LT), but some patients exceeding the Milan but fulfillin...

    Authors: Weiliang Xia, Qinghong Ke, Hua Guo, Weilin Wang, Min Zhang, Yan Shen, Jian Wu, Xiao Xu, Sheng Yan, Jun Yu, Mangli Zhang and Shusen Zheng
    Citation: BMC Cancer 2017 17:14
    Content type: Research article Published on:

  45. Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population s...

    Authors: Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa and Terenig Terjanian
    Citation: BMC Cancer 2017 17:13
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:443

  46. Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and...

    Authors: Messaouda Merzoug-Larabi, Caroline Spasojevic, Marianne Eymard, Caroline Hugonin, Christian Auclair and Manale Karam
    Citation: BMC Cancer 2017 17:12
    Content type: Research article Published on:

  47. Lymphatic metastasis, facilitated by lymphangiogenesis is a common occurrence in breast cancer, the molecular mechanisms remaining incompletely understood. We had earlier shown that cyclooxygenase (COX)-2 expr...

    Authors: Pinki Nandi, Gannareddy V. Girish, Mousumi Majumder, Xiping Xin, Elena Tutunea-Fatan and Peeyush K. Lala
    Citation: BMC Cancer 2017 17:11
    Content type: Research article Published on:

  48. The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is inevitable for many cancer patients, despite many impro...

    Authors: Ian A. Cree and Peter Charlton
    Citation: BMC Cancer 2017 17:10
    Content type: Review Published on:

  49. There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).

    Authors: Gabriela Gremel, Dijana Djureinovic, Marjut Niinivirta, Alexander Laird, Oscar Ljungqvist, Henrik Johannesson, Julia Bergman, Per-Henrik Edqvist, Sanjay Navani, Naila Khan, Tushar Patil, Ã…sa Sivertsson, Mathias Uhlén, David J. Harrison, Gustav J. Ullenhag, Grant D. Stewart…
    Citation: BMC Cancer 2017 17:9
    Content type: Research article Published on:

  50. Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular carcinoma (HCC), but no data existed for early-stage ...

    Authors: Leung Li, Frankie KF Mo, Stephen L Chan, Edwin P Hui, Nelson SL Tang, Jane Koh, Linda KS Leung, Annette NY Poon, Joyce Hui, Cheuk M Chu, Kit F Lee, Brigette BY Ma, Paul BS Lai, Anthony TC Chan, Simon CH Yu and Winnie Yeo
    Citation: BMC Cancer 2017 17:8
    Content type: Research article Published on:

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