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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Fibrinogen (FIB) is an important source of fibrin, which plays a crucial role in circulating tumor cells (CTCs) extravasation and distant metastasis development. We hypothesize it’s stable final product, plasm...

    Authors: Dongmei Diao, Yao Cheng, Yongchun Song, Hao Zhang, Zhangjian Zhou and Chengxue Dang

    Citation: BMC Cancer 2017 17:56

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  2. Content type: Research article

    No biomarker exists to guide the optimal choice of chemotherapy for patients with metastatic colorectal cancer. We examined the copy numbers (CN) of topoisomerase I (TOP1) as well as the ratios of TOP1/CEN-20 and...

    Authors: Jesper Andreas Palshof, Estrid Vilma Solyom Høgdall, Tim Svenstrup Poulsen, Dorte Linnemann, Benny Vittrup Jensen, Per Pfeiffer, Line Schmidt Tarpgaard, Nils Brünner, Jan Stenvang, Mette Yilmaz and Dorte Lisbet Nielsen

    Citation: BMC Cancer 2017 17:48

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  3. Content type: Research article

    BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA b...

    Authors: Simone Brandt, Eleftherios P. Samartzis, Anne-Katrin Zimmermann, Daniel Fink, Holger Moch, Aurelia Noske and Konstantin J. Dedes

    Citation: BMC Cancer 2017 17:44

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  4. Content type: Research article

    Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand the mechanism by which ...

    Authors: Noboru Nakaigawa, Keiichi Kondo, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Kazuki Kobayashi, Koichi Shioi, Ichiro Ikeda, Takeshi Kishida, Tomohiro Kaneta, Ryogo Minamimoto, Ukihide Tateishi, Tomio Inoue and Masahiro Yao

    Citation: BMC Cancer 2017 17:39

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  5. Content type: Research article

    PIK3CA mutations are expected to be potential therapeutic targets for esophageal squamous cell carcinoma (ESCC). We aimed to clarify the concordance between PIK3CA mutations detected i...

    Authors: Ken Hatogai, Satoshi Fujii, Takashi Kojima, Hiroyuki Daiko, Toshihiko Doi, Atsushi Ohtsu, Atsushi Ochiai, Yuichi Takiguchi and Takayuki Yoshino

    Citation: BMC Cancer 2017 17:36

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  6. Content type: Research article

    The quantitative analysis of microRNA (miRNA) gene expression in archived formalin-fixed, paraffin embedded (FFPE) tissues has been instrumental to identifying their potential roles in cancer biology, diagnosi...

    Authors: Sarah B. Peskoe, John R. Barber, Qizhi Zheng, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz and Shawn E. Lupold

    Citation: BMC Cancer 2017 17:32

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  7. Content type: Research article

    The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed ...

    Authors: Yuanyuan Xiao, Wen Chen, Zhihui Xie, Zhenyi Shao, Hua Xie, Guoyou Qin and Naiqing Zhao

    Citation: BMC Cancer 2017 17:25

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  8. Content type: Review

    The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is inevitable for many cancer patients, despite many impro...

    Authors: Ian A. Cree and Peter Charlton

    Citation: BMC Cancer 2017 17:10

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  9. Content type: Research article

    There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).

    Authors: Gabriela Gremel, Dijana Djureinovic, Marjut Niinivirta, Alexander Laird, Oscar Ljungqvist, Henrik Johannesson, Julia Bergman, Per-Henrik Edqvist, Sanjay Navani, Naila Khan, Tushar Patil, Åsa Sivertsson, Mathias Uhlén, David J. Harrison, Gustav J. Ullenhag, Grant D. Stewart…

    Citation: BMC Cancer 2017 17:9

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  10. Content type: Research article

    Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known about the relevance of this marker for the prognosis a...

    Authors: Mami Kaneko, Masanori Kotake, Hiroyuki Bando, Tetsuji Yamada, Hirofumi Takemura and Toshinari Minamoto

    Citation: BMC Cancer 2016 16:945

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  11. Content type: Research article

    Circulating cell-free DNA (ccf-DNA) in plasma may contain both specific and non-specific of tumor markers. The concentration and integrity of ccf-DNA may be clinical useful for detecting and predicting cancer ...

    Authors: Wang-Yang Pu, Rong Zhang, Li Xiao, Yong-You Wu, Wei Gong, Xiao-Dong Lv, Feng-Yun Zhong, Zhi-Xiang Zhuang, Xu-Ming Bai, Kai Li and Chun-Gen Xing

    Citation: BMC Cancer 2016 16:943

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  12. Content type: Research article

    In clinical practice the gold standard method to assess BRAF status in patients with metastatic melanoma is based on molecular assays. Recently, a mutation-specific monoclonal antibody (VE1), which detects the BR...

    Authors: Laura Schirosi, Sabino Strippoli, Francesca Gaudio, Giusi Graziano, Ondina Popescu, Michele Guida, Giovanni Simone and Anita Mangia

    Citation: BMC Cancer 2016 16:905

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  13. Content type: Research article

    Anillin (ANLN), an actin-binding protein required for cytokinesis, has recently been presented as part of a prognostic marker panel in breast cancer. The objective of the current study was to further explore t...

    Authors: Kristina Magnusson, Gabriela Gremel, Lisa Rydén, Victor Pontén, Mathias Uhlén, Anna Dimberg, Karin Jirström and Fredrik Pontén

    Citation: BMC Cancer 2016 16:904

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  14. Content type: Research article

    Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC re...

    Authors: Masato Takano, Keiji Shimada, Tomomi Fujii, Kohei Morita, Maiko Takeda, Yoshiyuki Nakajima, Akitaka Nonomura, Noboru Konishi and Chiho Obayashi

    Citation: BMC Cancer 2016 16:903

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  15. Content type: Research article

    Prognostic value of immune cells is not clear in testicular germ cell tumors (TGCTs). We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs.

    Authors: Yuta Yamada, Tohru Nakagawa, Toru Sugihara, Takamasa Horiuchi, Uran Yoshizaki, Tetsuya Fujimura, Hiroshi Fukuhara, Tomohiko Urano, Kenichi Takayama, Satoshi Inoue, Haruki Kume and Yukio Homma

    Citation: BMC Cancer 2016 16:898

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  16. Content type: Research article

    Cancer cells exhibit an altered metabolism, which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. Mitochondrial pyruvate carrier 1 (MPC1) and mitochondria...

    Authors: Xiaoli Li, Yasai Ji, Gaoyang Han, Xiaoran Li, Zhirui Fan, Yaqing Li, Yali Zhong, Jing Cao, Jing Zhao, Mingzhi Zhang, Jianguo Wen, Mariusz Adam Goscinski, Jahn M. Nesland and Zhenhe Suo

    Citation: BMC Cancer 2016 16:894

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  17. Content type: Research article

    This study aimed to assess the prognostic accuracy of serum CA 19-9 in patients with advanced lung adenocarcinoma.

    Authors: Yuki Sato, Daichi Fujimoto, Keiichiro Uehara, Ryoko Shimizu, Jiro Ito, Mariko Kogo, Shunsuke Teraoka, Ryoji Kato, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai and Keisuke Tomii

    Citation: BMC Cancer 2016 16:890

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  18. Content type: Research article

    High-mobility group protein box1 (HMGB1) is a pivotal factor in the development and progression of many types of tumor. Its role in hepatocellular carcinoma (HCC), and especially its correlation with intratumo...

    Authors: Qiang-Bo Zhang, Qing-an Jia, Hong Wang, Chun-Xiao Hu, Dong Sun, Run-De Jiang and Zong-Li Zhang

    Citation: BMC Cancer 2016 16:880

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  19. Content type: Research article

    Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal canc...

    Authors: Lei Zhou, Lan Yu, Bo Zhu, Shiwu Wu, Wenqing Song, Xiaomeng Gong and Danna Wang

    Citation: BMC Cancer 2016 16:876

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  20. Content type: Research article

    Tumor suppressive let-7 miRNAs are universally down-regulated in human hepatocellular carcinoma (HCC) versus normal tissues; however, the roles and related molecular mechanisms of let-7 in HCC stem cells are p...

    Authors: Bin Jin, Wei Wang, Xiang-xin Meng, Gang Du, Jia Li, Shi-zhe Zhang, Bing-hai Zhou and Zhi-hao Fu

    Citation: BMC Cancer 2016 16:863

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  21. Content type: Study protocol

    Bladder cancer is a very heterogeneous disease as regards natural history. Environmental exposures, constitutional genetic and/or epigenetic background may affect not only the likelihood of bladder tumor occur...

    Authors: Simone Benhamou, Julia Bonastre, Karine Groussard, François Radvanyi, Yves Allory and Thierry Lebret

    Citation: BMC Cancer 2016 16:837

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  22. Content type: Research article

    Previous studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression. We performed a systematic evaluation and meta-analysis to disclose the correlation...

    Authors: Rong Biaoxue, Liu Hua, Gao Wenlong and Yang Shuanying

    Citation: BMC Cancer 2016 16:836

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  23. Content type: Research article

    Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor supp...

    Authors: Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii…

    Citation: BMC Cancer 2016 16:805

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  24. Content type: Study protocol

    Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurab...

    Authors: Matthieu Hanf, David Chiron, Sophie de Visme, Cyrille Touzeau, Hervé Maisonneuve, Henry Jardel, Catherine Pellat-Deceunynck, Martine Amiot and Steven le Gouill

    Citation: BMC Cancer 2016 16:802

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  25. Content type: Research article

    Mutations in the tumor suppressor gene von Hippel-Lindau (VHL) underlie a hereditary cancer syndrome—VHL disease—and are also frequently observed in sporadic renal cell carcinoma of the clear cell type (ccRCC). V...

    Authors: Hannah L. Bader and Tien Hsu

    Citation: BMC Cancer 2016 16:797

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  26. Content type: Research article

    Serum C-reactive protein (CRP), an acute inflammatory response biomarker, has been recognized as an indicator of malignant disease progression. However, the prognostic significance of CRP levels collected befo...

    Authors: Zi-Ying Lin, Zhen-Xing Liang, Pei-Lin Zhuang, Jie-Wei Chen, Yun Cao, Li-Xu Yan, Jing-Ping Yun, Dan Xie and Mu-Yan Cai

    Citation: BMC Cancer 2016 16:792

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  27. Content type: Research article

    Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an imp...

    Authors: Chenbo Ding, Longmei Li, Taoyu Yang, Xiaobo Fan and Guoqiu Wu

    Citation: BMC Cancer 2016 16:791

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  28. Content type: Research article

    TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesopha...

    Authors: David Propper, Keith Jones, D. Alan Anthoney, Wasat Mansoor, Daniel Ford, Martin Eatock, Roshan Agarwal, Michiyasu Inatani, Tomohisa Saito, Masaichi Abe and T. R. Jeffry Evans

    Citation: BMC Cancer 2016 16:779

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  29. Content type: Research article

    Targeted therapies based on the molecular and histological features of cancer types are becoming standard practice. The most effective regimen in lung cancers is different between squamous cell carcinoma (SCC)...

    Authors: Kazuya Takamochi, Hiroko Ohmiya, Masayoshi Itoh, Kaoru Mogushi, Tsuyoshi Saito, Kieko Hara, Keiko Mitani, Yasushi Kogo, Yasunari Yamanaka, Jun Kawai, Yoshihide Hayashizaki, Shiaki Oh, Kenji Suzuki and Hideya Kawaji

    Citation: BMC Cancer 2016 16:760

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  30. Content type: Research article

    Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumours with a typical 5 year survival rate of <40 %. DNA methylation in tumour-suppressor genes often occurs at an early stage of tumo...

    Authors: Yenkai Lim, Yunxia Wan, Dimitrios Vagenas, Dmitry A. Ovchinnikov, Chris F. L. Perry, Melissa J. Davis and Chamindie Punyadeera

    Citation: BMC Cancer 2016 16:749

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  31. Content type: Research article

    While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers...

    Authors: Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore…

    Citation: BMC Cancer 2016 16:744

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  32. Content type: Research article

    The incidence of Papillary thyroid carcinoma (PTC), the most common type of thyroid malignancy, has risen rapidly worldwide. PTC usually has an excellent prognosis. However, the rising incidence of PTC, due at...

    Authors: Kevin Brennan, Christopher Holsinger, Chrysoula Dosiou, John B. Sunwoo, Haruko Akatsu, Robert Haile and Olivier Gevaert

    Citation: BMC Cancer 2016 16:736

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  33. Content type: Research article

    The purpose of our research was to determine the prognostic impact and clinicopathological feature of c-MYC and β-catenin overexpression in colorectal cancer (CRC) patients.

    Authors: Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim and Hye Seung Lee

    Citation: BMC Cancer 2016 16:730

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  34. Content type: Research article

    The primary cause of treatment failure in medulloblastomas (MB) is the development of leptomeningeal dissemination (seeding). For translational research on MB seeding, one of the major challenges is the develo...

    Authors: Seung Ah Choi, Pil Ae Kwak, Seung-Ki Kim, Sung-Hye Park, Ji Yeoun Lee, Kyu-Chang Wang, Hyun Jeong Oh, Kyuwan Kim, Dong Soo Lee, Do Won Hwang and Ji Hoon Phi

    Citation: BMC Cancer 2016 16:723

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  35. Content type: Research article

    We hypothesized that pretreatment serum levels of insulin and other serum markers would predict Progression-free survival (PFS), defined as time to castration-resistant progression or death, in metastatic andr...

    Authors: Farshid Dayyani, Amado J. Zurita, Graciela M. Nogueras-González, Rebecca Slack, Randall E. Millikan, John C. Araujo, Gary E. Gallick, Christopher J. Logothetis and Paul G. Corn

    Citation: BMC Cancer 2016 16:721

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  36. Content type: Research article

    Although radiotherapy following mastectomy was demonstrated to reduce the recurring risk and improve the prognosis of patients with breast cancer, it is also notorious for comprehensive side effects, hence onl...

    Authors: Li Min, Cheng Zhang, Ruolan Ma, Xiaofan Li, Hua Yuan, Yihao Li, Ruxuan Chen, Caiyun Liu, Jianping Guo, Like Qu and Chengchao Shou

    Citation: BMC Cancer 2016 16:717

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  37. Content type: Research article

    We previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression. In the present study, we aimed to inv...

    Authors: Zhengyu Fang, Shanshan Zhang, Yufan Wang, Shiyue Shen, Feng Wang, Yinghua Hao, Yuxia Li, Bingyue Zhang, You Zhou and Hongyu Yang

    Citation: BMC Cancer 2016 16:706

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  38. Content type: Research article

    Pathologic complete response (pCR) after neoadjuvant chemotherapy for breast cancer is associated with improved prognosis in aggressive tumor subtypes, including ERBB2- positive tumors. Recent adoption of pCR ...

    Authors: Benjamin C. Calhoun, Bryce Portier, Zhen Wang, Eugen C. Minca, G. Thomas Budd, Christopher Lanigan, Raymond R. Tubbs and Larry E. Morrison

    Citation: BMC Cancer 2016 16:695

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  39. Content type: Research article

    T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence and progression. Recent studies have shown that high expression levels of Tiam1 protein appear to be associ...

    Authors: Zhenling Li, Qixiang Liu, Junjie Piao, Fenjian Hua, Jing Wang, Guang Jin, Zhenhua Lin and Yan Zhang

    Citation: BMC Cancer 2016 16:681

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  40. Content type: Research article

    Chromosome 3 amplification affecting the 3q26 region is a common genomic alteration in cervical cancer, typically marking the transition of precancerous intraepithelial lesions to an invasive phenotype. Though...

    Authors: Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer and Zoltan Ferenc Takacs

    Citation: BMC Cancer 2016 16:676

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  41. Content type: Research article

    Women harboring BRCA1/2 germline mutations have high lifetime risk of developing breast/ovarian cancer. The recommendation to pursue BRCA1/2 testing is based on patient’s family history of breast/ovarian cancer, ...

    Authors: Muhammad Usman Rashid, Noor Muhammad, Seerat Bajwa, Saima Faisal, Muhammad Tahseen, Justo Lorenzo Bermejo, Asim Amin, Asif Loya and Ute Hamann

    Citation: BMC Cancer 2016 16:673

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  42. Content type: Research article

    Ampullary adenocarcinoma is a rare gastrointestinal cancer associated with diverse outcomes due to clinical and pathological heterogeneity. Standardized methods to better prognosticate and inform therapeutic s...

    Authors: Michael J. Overman, Harris S. Soifer, Aaron Joel Schueneman, Joe Ensor Jr, Volkan Adsay, Burcu Saka, Nastaran Neishaboori, Robert A. Wolff, Huamin Wang, Catherine A. Schnabel and Gauri Varadhachary

    Citation: BMC Cancer 2016 16:668

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  43. Content type: Research article

    Treatment for localized soft tissue sarcoma includes surgery and radiation, while the role of chemotherapy is controversial. Biomarkers that could predict therapeutic response or prognosticate overall survival...

    Authors: Elizabeth J. Davis, Lili Zhao, David R. Lucas, Scott M. Schuetze, Laurence H. Baker, Mark M. Zalupski, Dafydd Thomas and Rashmi Chugh

    Citation: BMC Cancer 2016 16:663

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  44. Content type: Research article

    Intraperitoneal chemotherapy is used to treat peritoneal cancer. The pattern of gene expression changes of peritoneal cancer during intraperitoneal chemotherapy has not been studied before. Pressurized intrape...

    Authors: Günther A. Rezniczek, Friederike Jüngst, Hendrik Jütte, Andrea Tannapfel, Ziad Hilal, Lukas A. Hefler, Marc-André Reymond and Clemens B. Tempfer

    Citation: BMC Cancer 2016 16:654

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  45. Content type: Research article

    Her2/neu is an oncogene that plays an important role in the pathogenesis of many cancer types. In bladder carcinoma (BC), the clinical significance of Her2/neu status remains under-investigated and poorly linked ...

    Authors: Taoufik Nedjadi, Jaudah Al-Maghrabi, Mourad Assidi, Ashraf Dallol, Heba Al-Kattabi, Adeel Chaudhary, Ahmed Al-Sayyad, Adel Al-Ammari, Adel Abuzenadah, Abdelbaset Buhmeida and Mohammed Al-Qahtani

    Citation: BMC Cancer 2016 16:653

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