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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices. The present study has focussed on S100 proteins as a p...

    Authors: Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz and Ida Pucci-Minafra

    Citation: BMC Cancer 2010 10:476

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  2. Content type: Research article

    Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We aimed to determine whether inhibitors of differentiation 1 (Id1) were expressed in circulating EPCs of patients with ovarian ...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Jie Bao, Zhen Cai and Ailan Liu

    Citation: BMC Cancer 2010 10:459

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  3. Content type: Research article

    In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mec...

    Authors: Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa and Akio Yamaguchi

    Citation: BMC Cancer 2010 10:443

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  4. Content type: Research article

    Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical tri...

    Authors: Jan N Kreutzer, Maria Ruzzene and Barbara Guerra

    Citation: BMC Cancer 2010 10:440

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  5. Content type: Research article

    Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment in many cancer types. However, the significance of NF-κB pathway for compl...

    Authors: Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang and Wan-tao Chen

    Citation: BMC Cancer 2010 10:437

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  6. Content type: Research article

    We investigated the distribution and clinical significance of mobilized endothelial progenitor cells (EPCs) in hepatocellular carcinoma (HCC). We found that many more EPCs were recruited to nonmalignant liver ...

    Authors: De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang and Yi-tao Ding

    Citation: BMC Cancer 2010 10:435

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  7. Content type: Research article

    Chloroquine (CQ), the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. It has been sh...

    Authors: Kazuhito Sasaki, Nelson H Tsuno, Eiji Sunami, Giichiro Tsurita, Kazushige Kawai, Yurai Okaji, Takeshi Nishikawa, Yasutaka Shuno, Kumiko Hongo, Masaya Hiyoshi, Manabu Kaneko, Joji Kitayama, Koki Takahashi and Hirokazu Nagawa

    Citation: BMC Cancer 2010 10:370

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  8. Content type: Research article

    Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We h...

    Authors: Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari and Caroline A Lamb

    Citation: BMC Cancer 2010 10:293

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