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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    CDCP1, a transmembrane protein with tumor pro-metastatic activity, was recently identified as a prognostic marker in TNBC, the most aggressive breast cancer subtype still lacking an effective molecular targete...

    Authors: Luca Forte, Federica Turdo, Cristina Ghirelli, Piera Aiello, Patrizia Casalini, Marilena Valeria Iorio, Elvira D’Ippolito, Patrizia Gasparini, Roberto Agresti, Beatrice Belmonte, Gabriella Sozzi, Lucia Sfondrini, Elda Tagliabue, Manuela Campiglio and Francesca Bianchi

    Citation: BMC Cancer 2018 18:586

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  2. Content type: Research article

    Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis i...

    Authors: Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone and Koyamangalath Krishnan

    Citation: BMC Cancer 2018 18:564

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  3. Content type: Case report

    Renal epithelioid angiomyolipomas (EAML) are rare tumors with aggressive behavior. EAML can be sporadic or develop within the tuberous sclerosis complex syndrome, where mutations of TSC1 or TSC2 genes (critical n...

    Authors: Marta Espinosa, Juan Maria Roldán-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo and Cristina Rodriguez-Antona

    Citation: BMC Cancer 2018 18:561

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  4. Content type: Research article

    It is frequently asked whether chemotherapy can still play a role in metastatic melanoma considering the effectiveness of the available drugs today, including antiCTLA4/antiPD1 immunotherapy and antiBRAF/antiM...

    Authors: Michele Guida, Stefania Tommasi, Sabino Strippoli, Maria Iole Natalicchio, Simona De Summa, Rosamaria Pinto, Antonio Cramarossa, Anna Albano, Salvatore Pisconti, Michele Aieta, Ruggiero Ridolfi, Amalia Azzariti, Gabriella Guida, Vito Lorusso and Giusepe Colucci

    Citation: BMC Cancer 2018 18:552

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  5. Content type: Research article

    Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab....

    Authors: Maurizio Martini, Ivana de Pascalis, Quintino Giorgio D’Alessandris, Vincenzo Fiorentino, Francesco Pierconti, Hany El-Sayed Marei, Lucia Ricci-Vitiani, Roberto Pallini and Luigi Maria Larocca

    Citation: BMC Cancer 2018 18:553

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  6. Content type: Research article

    An important component of the RAS signalling pathway, the RAS p21 oncogene, is frequently hyperactivated in breast cancer. Its expression in tumor tissue has been linked to poor clinical outcome. This study wa...

    Authors: Malgorzata Banys-Paluchowski, Tanja Fehm, Wolfgang Janni, Bahriye Aktas, Peter A. Fasching, Sabine Kasimir-Bauer, Karin Milde-Langosch, Klaus Pantel, Brigitte Rack, Sabine Riethdorf, Erich-Franz Solomayer, Isabell Witzel and Volkmar Müller

    Citation: BMC Cancer 2018 18:541

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  7. Content type: Research article

    Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group...

    Authors: Chanhee Lee, Joongyub Lee, Seung Ah Choi, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Se Hoon Kim, Ji Yeoun Lee and Ji Hoon Phi

    Citation: BMC Cancer 2018 18:535

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  8. Content type: Research article

    The 21-gene Recurrence Score (RS) result predicts outcome and chemotherapy benefit in node-negative and node-positive (N+), estrogen receptor-positive (ER+) patients treated with endocrine therapy. The purpose...

    Authors: Frédérique Penault-Llorca, Thomas Filleron, Bernard Asselain, Frederick L. Baehner, Pierre Fumoleau, Magali Lacroix-Triki, Joseph M. Anderson, Carl Yoshizawa, Diana B. Cherbavaz, Steven Shak, Lise Roca, Christine Sagan, Jérôme Lemonnier, Anne-Laure Martin and Henri Roché

    Citation: BMC Cancer 2018 18:526

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  9. Content type: Research article

    The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin...

    Authors: Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu and Markus J. Riemenschneider

    Citation: BMC Cancer 2018 18:524

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  10. Content type: Research article

    Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear.

    Authors: Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim and Yoon Ho Ko

    Citation: BMC Cancer 2018 18:506

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  11. Content type: Research article

    Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized t...

    Authors: Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola and Heikki Joensuu

    Citation: BMC Cancer 2018 18:504

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  12. Content type: Research article

    6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particular...

    Authors: Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou and Yong Han

    Citation: BMC Cancer 2018 18:516

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  13. Content type: Research article

    Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is ne...

    Authors: Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa and Naoaki Matsuki

    Citation: BMC Cancer 2018 18:472

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  14. Content type: Research article

    Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the...

    Authors: Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze, Mikihiro Kohno, Mei-Lin Chan, Yidan Zhao, Emanuela Felley-Bosco, Beat Schwaller and Marc de Perrot

    Citation: BMC Cancer 2018 18:471

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  15. Content type: Research article

    Breast cancer is a heterogeneous disease and personalized medicine is the hope for the improvement of the clinical outcome. Multi-gene signatures for breast cancer stratification have been extensively studied ...

    Authors: Shujun Huang, Leigh Murphy and Wayne Xu

    Citation: BMC Cancer 2018 18:473

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  16. Content type: Research article

    Microsatellite instability (MSI) is a major predictive and diagnostic marker in several cancers including colorectal carcinomas. Diagnostic testing for microsatellites is generally performed using capillary se...

    Authors: Isabel Förster, Michael Brockmann, Oliver Schildgen and Verena Schildgen

    Citation: BMC Cancer 2018 18:484

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  17. Content type: Research article

    Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like...

    Authors: Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner and Jens Neumann

    Citation: BMC Cancer 2018 18:483

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  18. Content type: Research article

    Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable an...

    Authors: Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao and Qinghua Xia

    Citation: BMC Cancer 2018 18:434

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  19. Content type: Research article

    In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated prostaglandin (PG) E2 synthesis have been associated with tumor development and progression. The potential of COX-2 inhibitors in cance...

    Authors: Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke…

    Citation: BMC Cancer 2018 18:431

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  20. Content type: Research article

    The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like ...

    Authors: Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao and Céline Mascaux

    Citation: BMC Cancer 2018 18:429

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  21. Content type: Research article

    We aimed to assess the prognostic value of CYFRA 21-1 in a series of patients with anal canal squamous cell carcinoma treated by radiation-based therapy.

    Authors: Mathieu Gauthé, Marion Richard-Molard, Eugénie Rigault, Bruno Buecher, Pascale Mariani, Dominique Bellet, Wulfran Cacheux and Astrid Lièvre

    Citation: BMC Cancer 2018 18:417

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  22. Content type: Research article

    The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion....

    Authors: Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng…

    Citation: BMC Cancer 2018 18:400

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  23. Content type: Research article

    The anticancer immune response has been reported to correlate with cancer progression. Tumor-infiltrating lymphocytes (TILs), which are one of the indicators of host immunity, affect the tumor growth, metastas...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2018 18:371

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  24. Content type: Research article

    Growth differentiation factor 15 (GDF15) has attracted much interest as a novel biomarker for epithelial ovarian carcinoma (EOC). Research focus has been directed at GDF15 as a diagnostic detection, while the ...

    Authors: Dan Zhao, Xiaobing Wang and Wei Zhang

    Citation: BMC Cancer 2018 18:328

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  25. Content type: Research article

    Cervical cancer (CC) is the fourth cause of mortality by neoplasia in women worldwide. The use of immunomarkers is an alternative tool to complement currently used algorithms for detection of cancer, and to im...

    Authors: Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López and Miguel A. Mendoza-Catalán

    Citation: BMC Cancer 2018 18:349

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  26. Content type: Research article

    Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast ...

    Authors: Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang and Shusen Wang

    Citation: BMC Cancer 2018 18:331

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  27. Content type: Research article

    Recent studies have shown that tumors with extensive tumor-infiltrating lymphocytes (TILs) have a higher probability of pathologic complete response, even in luminal/human epidermal growth factor 2 (HER2)-nega...

    Authors: Sung Gwe Ahn, Yoon Jin Cha, Soon June Bae, Chanik Yoon, Hak Woo Lee and Joon Jeong

    Citation: BMC Cancer 2018 18:320

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  28. Content type: Research article

    The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemothe...

    Authors: Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi and Jeffrey A. Borgia

    Citation: BMC Cancer 2018 18:310

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  29. Content type: Study protocol

    Colorectal cancer (CRC) is the second most common cause of all cancer deaths in Europe and the Western world with a lifetime risk of approximately 5%. Despite several improvements in the treatment of patients ...

    Authors: Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther and Ulrike Stein

    Citation: BMC Cancer 2018 18:297

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  30. Content type: Research article

    The introduction of targeted treatments for subsets of non-small cell lung cancer (NSCLC) has highlighted the importance of accurate molecular diagnosis to determine if an actionable genetic alteration is pres...

    Authors: Ales Ryska, Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank and Jozsef Timar

    Citation: BMC Cancer 2018 18:269

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  31. Content type: Research article

    We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-bindin...

    Authors: Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen and Bjarne W. Kristensen

    Citation: BMC Cancer 2018 18:270

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  32. Content type: Research article

    Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive meta...

    Authors: Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A. Stuck, Stephan Lang, Agnes Bankfalvi and Sven Brandau

    Citation: BMC Cancer 2018 18:272

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  33. Content type: Research article

    CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clini...

    Authors: Tao Jiang, Xiaofeng Xu, Meng Qiao, Xuefei Li, Chao Zhao, Fei Zhou, Guanghui Gao, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Changyun Zhai and Caicun Zhou

    Citation: BMC Cancer 2018 18:267

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  34. Content type: Research article

    Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to b...

    Authors: Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu…

    Citation: BMC Cancer 2018 18:259

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  35. Content type: Research article

    Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog. The purpose of this study was to fully characterize a no...

    Authors: Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel and Vilma Yuzbasiyan-Gurkan

    Citation: BMC Cancer 2018 18:237

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  36. Content type: Research article

    The subtype of claudin-low breast cancer can be reliably determined only by gene-expression profiling. Attempts have been made to develop immunohistochemical surrogates, which nearly always focus on membranous...

    Authors: Anniina Jääskeläinen, Ylermi Soini, Arja Jukkola-Vuorinen, Päivi Auvinen, Kirsi-Maria Haapasaari and Peeter Karihtala

    Citation: BMC Cancer 2018 18:223

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  37. Content type: Research article

    Post-surgical prognosis is usually poor for combined hepatocellular cholangiocarcinoma (CHCC-CC), a rare primary liver cancer. Although midkine (MK) is a prognostic biomarker for several known cancers, it is n...

    Authors: Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien and Yen-Yang Chen

    Citation: BMC Cancer 2018 18:227

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  38. Content type: Research article

    The assessment of circulating tumor cells (CTCs) has been shown to enable monitoring of treatment response and early detection of metastatic breast cancer (MBC) recurrence. The aim of this study was to compare...

    Authors: Hanna Huebner, Peter A. Fasching, Walter Gumbrecht, Sebastian Jud, Claudia Rauh, Mark Matzas, Peter Paulicka, Katja Friedrich, Michael P. Lux, Bernhard Volz, Paul Gass, Lothar Häberle, Franziska Meier-Stiegen, Andreas Hartkopf, Hans Neubauer, Katrin Almstedt…

    Citation: BMC Cancer 2018 18:204

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  39. Content type: Research article

    Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma ...

    Authors: Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu and Shusen Zheng

    Citation: BMC Cancer 2018 18:200

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  40. Content type: Research article

    Though peritoneal carcinomatosis reflects a late stage of colorectal cancer (CRC), only few patients present with synchronous or metachronous liver metastases alongside their peritoneal carcinomatosis. It is h...

    Authors: Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V. Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann and Martin Kurt Angele

    Citation: BMC Cancer 2018 18:201

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  41. Content type: Research article

    Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. ...

    Authors: Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard and Boe Sandahl Sorensen

    Citation: BMC Cancer 2018 18:191

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  42. Content type: Research article

    Several efforts have been focused on identification of pathways involved in malignancy, progression, and response to treatment in Glioblastoma (GB). Overexpression of PKCε was detected in histological samples ...

    Authors: Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski and Maria Rybczynska

    Citation: BMC Cancer 2018 18:185

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  43. Content type: Research article

    The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK...

    Authors: Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills and Bryan T. Hennessy

    Citation: BMC Cancer 2018 18:168

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  44. Content type: Research article

    Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synt...

    Authors: Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed and Henrik Antti

    Citation: BMC Cancer 2018 18:167

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    The Correction to this article has been published in BMC Cancer 2018 18:268

  45. Content type: Research article

    Oropharyngeal Squamous Cell Carcinoma (OPSCC) is increasing in incidence despite a decline in traditional risk factors. Human Papilloma Virus (HPV), specifically subtypes 16, 18, 31 and 35, has been implicated...

    Authors: Mitchell G. Rohatensky, Devon M. Livingstone, Paul Mintchev, Heather K. Barnes, Steven C. Nakoneshny, Douglas J. Demetrick, Joseph C. Dort and Guido van Marle

    Citation: BMC Cancer 2018 18:166

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  46. Content type: Research article

    Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with...

    Authors: Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky and Kornélia Baghy

    Citation: BMC Cancer 2018 18:157

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