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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin...

    Authors: Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu and Markus J. Riemenschneider

    Citation: BMC Cancer 2018 18:524

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  2. Content type: Research article

    Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear.

    Authors: Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim and Yoon Ho Ko

    Citation: BMC Cancer 2018 18:506

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  3. Content type: Research article

    Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized t...

    Authors: Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola and Heikki Joensuu

    Citation: BMC Cancer 2018 18:504

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  4. Content type: Research article

    6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particular...

    Authors: Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou and Yong Han

    Citation: BMC Cancer 2018 18:516

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  5. Content type: Research article

    Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is ne...

    Authors: Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa and Naoaki Matsuki

    Citation: BMC Cancer 2018 18:472

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  6. Content type: Research article

    Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the...

    Authors: Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze, Mikihiro Kohno, Mei-Lin Chan, Yidan Zhao, Emanuela Felley-Bosco, Beat Schwaller and Marc de Perrot

    Citation: BMC Cancer 2018 18:471

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  7. Content type: Research article

    Breast cancer is a heterogeneous disease and personalized medicine is the hope for the improvement of the clinical outcome. Multi-gene signatures for breast cancer stratification have been extensively studied ...

    Authors: Shujun Huang, Leigh Murphy and Wayne Xu

    Citation: BMC Cancer 2018 18:473

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  8. Content type: Research article

    Microsatellite instability (MSI) is a major predictive and diagnostic marker in several cancers including colorectal carcinomas. Diagnostic testing for microsatellites is generally performed using capillary se...

    Authors: Isabel Förster, Michael Brockmann, Oliver Schildgen and Verena Schildgen

    Citation: BMC Cancer 2018 18:484

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  9. Content type: Research article

    Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like...

    Authors: Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner and Jens Neumann

    Citation: BMC Cancer 2018 18:483

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  10. Content type: Research article

    Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable an...

    Authors: Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao and Qinghua Xia

    Citation: BMC Cancer 2018 18:434

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  11. Content type: Research article

    In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated prostaglandin (PG) E2 synthesis have been associated with tumor development and progression. The potential of COX-2 inhibitors in cance...

    Authors: Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke…

    Citation: BMC Cancer 2018 18:431

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  12. Content type: Research article

    The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like ...

    Authors: Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao and Céline Mascaux

    Citation: BMC Cancer 2018 18:429

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  13. Content type: Research article

    We aimed to assess the prognostic value of CYFRA 21-1 in a series of patients with anal canal squamous cell carcinoma treated by radiation-based therapy.

    Authors: Mathieu Gauthé, Marion Richard-Molard, Eugénie Rigault, Bruno Buecher, Pascale Mariani, Dominique Bellet, Wulfran Cacheux and Astrid Lièvre

    Citation: BMC Cancer 2018 18:417

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  14. Content type: Research article

    The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion....

    Authors: Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng…

    Citation: BMC Cancer 2018 18:400

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  15. Content type: Research article

    The anticancer immune response has been reported to correlate with cancer progression. Tumor-infiltrating lymphocytes (TILs), which are one of the indicators of host immunity, affect the tumor growth, metastas...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2018 18:371

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  16. Content type: Research article

    Cervical cancer (CC) is the fourth cause of mortality by neoplasia in women worldwide. The use of immunomarkers is an alternative tool to complement currently used algorithms for detection of cancer, and to im...

    Authors: Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López and Miguel A. Mendoza-Catalán

    Citation: BMC Cancer 2018 18:349

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  17. Content type: Research article

    Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast ...

    Authors: Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang and Shusen Wang

    Citation: BMC Cancer 2018 18:331

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