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BMC Cancer

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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors...

    Authors: Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi and Isabelle Bernard-Pierrot

    Citation: BMC Cancer 2017 17:636

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  2. Content type: Research article

    Prostate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important ...

    Authors: Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M. McKee, Clare Verrill, Richard J. Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans and Ruth J. Muschel

    Citation: BMC Cancer 2017 17:634

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  3. Content type: Research article

    Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical s...

    Authors: Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima and Masatoshi Tagawa

    Citation: BMC Cancer 2017 17:622

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  4. Content type: Research article

    MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptos...

    Authors: Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis and Eduardas Aleknavicius

    Citation: BMC Cancer 2017 17:607

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  5. Content type: Research article

    Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) is an efficient biomarker specific for hepatocellular carcinoma (HCC). Some researchers have proved that levels of PIVKA-II reflect HCC oncogene...

    Authors: Rentao Yu, Zhaoxia Tan, Xiaomei Xiang, Yunjie Dan and Guohong Deng

    Citation: BMC Cancer 2017 17:608

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  6. Content type: Research article

    Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this stu...

    Authors: Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara and Yasuhiro Kodera

    Citation: BMC Cancer 2017 17:610

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  7. Content type: Research article

    The recently developed reagent, eribulin mesylate (eribulin), is a microtubule dynamics inhibitor with a mechanism of action that differs from those of taxanes and vinca alkaloids. This drug is considered to b...

    Authors: Shinichiro Kashiwagi, Wakaba Fukushima, Yuka Asano, Wataru Goto, Koji Takada, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2017 17:604

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  8. Content type: Research article

    N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is involved in the development of human cancers. Prev...

    Authors: Qijiong Li, Xiaofeng Liu, Kemin Jin, Min Lu, Chunfeng Zhang, Xiaojuan Du and Baocai Xing

    Citation: BMC Cancer 2017 17:605

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  9. Content type: Research article

    The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and w...

    Authors: Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao and Hung-Ming Wang

    Citation: BMC Cancer 2017 17:592

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  10. Content type: Research article

    Neuron-Specific enolase (NSE) has been used as a typical tumor marker and shows a potential to diagnose malignant pleural effusion (MPE). The ability of NSE in diagnosing MPE has been investigated in many stud...

    Authors: Jing Zhu, Mei Feng, Liqun Liang, Ni Zeng, Chun Wan, Ting Yang, Yongchun Shen and Fuqiang Wen

    Citation: BMC Cancer 2017 17:590

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  11. Content type: Research article

    The Empty Spiracles Homeobox (EMX-) 2 gene has been associated with regulation of growth and differentiation in neuronal development. While recent studies provide evidence that EMX2 regulates tumorigenesis of ...

    Authors: Berk Aykut, Markus Ochs, Praveen Radhakrishnan, Adrian Brill, Hermine Höcker, Sandra Schwarz, Daniel Weissinger, Roland Kehm, Yakup Kulu, Alexis Ulrich and Martin Schneider

    Citation: BMC Cancer 2017 17:555

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  12. Content type: Research article

    The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease-related mortality. In our study, the relationship between pretreatment serum LFTs and overall survival (OS)...

    Authors: Hao Huang, Xue-Ping Wang, Xiao-Hui Li, Hao Chen, Xin Zheng, Jian-Hua Lin, Ting Kang, Lin Zhang and Pei-Song Chen

    Citation: BMC Cancer 2017 17:544

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  13. Content type: Research article

    Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine stra...

    Authors: Doo-Yi Oh, Kyungsoo Jung, Ji-Young Song, Seokhwi Kim, Sang Shin, Yong-Jun Kwon, Ensel Oh, Woong-Yang Park, Sang Yong Song and Yoon-La Choi

    Citation: BMC Cancer 2017 17:535

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  14. Content type: Research article

    Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different ...

    Authors: A. Fricke, P. V. Ullrich, A. F. V. Cimniak, C. Becherer, M. Follo, J. Heinz, J. Scholber, G. W. Herget, O. Hauschild, U. A. Wittel, G. B. Stark, H. Bannasch, D. Braig and S. U. Eisenhardt

    Citation: BMC Cancer 2017 17:527

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  15. Content type: Research article

    We investigated whether GSTT1 (“null” allele), GSTM1 (“null”allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast ca...

    Authors: Vienna Ludovini, Cinzia Antognelli, Antonio Rulli, Jennifer Foglietta, Lorenza Pistola, Rulli Eliana, Irene Floriani, Giuseppe Nocentini, Francesca Romana Tofanetti, Simonetta Piattoni, Elisa Minenza, Vincenzo Nicola Talesa, Angelo Sidoni, Maurizio Tonato, Lucio Crinò and Stefania Gori

    Citation: BMC Cancer 2017 17:502

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  16. Content type: Research article

    Despite the near universal occurrence of activating codon 12 KRAS somatic variants in pancreatic cancer, there is considerable heterogeneity in the molecular make-up, MAPK/ERK pathway activation states, and cl...

    Authors: Humair S. Quadri, Taylor J. Aiken, Michael Allgaeuer, Radim Moravec, Sean Altekruse, S. Perwez Hussain, Markku M. Miettinen, Stephen M. Hewitt and Udo Rudloff

    Citation: BMC Cancer 2017 17:495

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  17. Content type: Research article

    CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 express...

    Authors: Yao-Li Chen, Ping-Yi Lin, Ying-Zi Ming, Wei-Chieh Huang, Rong-Fu Chen, Po-Ming Chen and Pei-Yi Chu

    Citation: BMC Cancer 2017 17:474

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  18. Content type: Research article

    Due to high mortality and lack of efficient screening, new tools for ovarian cancer (OC) diagnosis are urgently needed. To broaden the knowledge on the pathological processes that occur during ovarian cancer t...

    Authors: Agata Swiatly, Agnieszka Horala, Joanna Hajduk, Jan Matysiak, Ewa Nowak-Markwitz and Zenon J. Kokot

    Citation: BMC Cancer 2017 17:472

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