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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Members of the urokinase-type plasminogen activator (uPA) system are up-regulated in various solid malignant tumors. High antigen levels of uPA, its inhibitor PAI-1 and its receptor uPAR have recently been sho...

    Authors: Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl and Helge Taubert

    Citation: BMC Cancer 2011 11:273

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  2. Content type: Research article

    Although FOXO transcription factors may have an anti-angiogenic role, little is known about their role in tumor angiogenesis. The present study was performed to investigate the correlation between the constitu...

    Authors: Sue Youn Kim, Jiyeon Yoon, Young San Ko, Mee Soo Chang, Jong-Wan Park, Hee Eun Lee, Min A Kim, Ji Hun Kim, Woo Ho Kim and Byung Lan Lee

    Citation: BMC Cancer 2011 11:264

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  3. Content type: Research article

    Triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC) are breast cancer subtypes with an especially poor prognosis. 8-Hydroxydeoxyguanosine (8-OHdG) is a widely used marker of oxidative stre...

    Authors: Peeter Karihtala, Saila Kauppila, Ylermi Soini and Arja-Jukkola-Vuorinen

    Citation: BMC Cancer 2011 11:262

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  4. Content type: Research article

    Bladder cancer is a significant healthcare problem in the United States of America with a high recurrence rate. Early detection of bladder cancer is essential for removing the tumor with preservation of the bl...

    Authors: Antara Datta, Martin E Adelson, Yakov Mogilevkin, Eli Mordechai, Abraham A Sidi and Jason P Trama

    Citation: BMC Cancer 2011 11:234

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  5. Content type: Research article

    Prognostic factors in predicting occult lymph node metastasis in patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of the sentinel lymph node procedure in this tu...

    Authors: Gerhard F Huber, Lena Züllig, Alex Soltermann, Matthias Roessle, Nicole Graf, Stephan K Haerle, Gabriela Studer, Wolfram Jochum, Holger Moch and Sandro J Stoeckli

    Citation: BMC Cancer 2011 11:217

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  6. Content type: Research article

    Chemokines and chemokine receptors are major actors of leukocytes trafficking and some have been shown to play an important role in cancer metastasis. Chemokines CCL19, CCL20 and CCL21 and their receptors CCR6...

    Authors: Philippe A Cassier, Isabelle Treilleux, Thomas Bachelot, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare, Christine Ménétrier-Caux, Olivier Trédan, Sophie Goddard-Léon, Jean-Jacques Pin, Hervé Mignotte, Clarisse Bathélémy-Dubois, Christophe Caux, Serge Lebecque and Jean-Yves Blay

    Citation: BMC Cancer 2011 11:213

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  7. Content type: Research article

    L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study co...

    Authors: Hilke Zander, Tamina Rawnaq, Max von Wedemeyer, Michael Tachezy, Miriam Kunkel, Gerrit Wolters, Maximilian Bockhorn, Melitta Schachner, Jakob R Izbicki and Jussuf Kaifi

    Citation: BMC Cancer 2011 11:189

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  8. Content type: Research article

    As a negative modulator of the canonical Wnt signaling pathway, Naked1 (NKD1) is widely expressed in many normal tissues. However, the expression pattern and clinicopathological significance of NKD1 in patient...

    Authors: Sheng Zhang, Yan Wang, Shun-Dong Dai and En-Hua Wang

    Citation: BMC Cancer 2011 11:186

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  9. Content type: Research article

    Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1...

    Authors: Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein and Peter R Mertens

    Citation: BMC Cancer 2011 11:185

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  10. Content type: Research article

    To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.

    Authors: Jing Gao, Ming Lu, Jing-wei Yu, Yan-yan Li and Lin Shen

    Citation: BMC Cancer 2011 11:177

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  11. Content type: Research article

    Bladder cancer, the 5th most common malignancy in the USA, is often detected as a result of incidental findings or by presenting hematuria. Once diagnosed the disease is one of the costliest cancers to treat due ...

    Authors: Anuradha Murali, Laura Kasman and Christina Voelkel-Johnson

    Citation: BMC Cancer 2011 11:168

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  12. Content type: Research article

    The cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are upregulated under hypoxic conditions. We examined the staining patterns and co-expression of ...

    Authors: Saskia E Rademakers, Jasper Lok, Albert J van der Kogel, Johan Bussink and Johannes HAM Kaanders

    Citation: BMC Cancer 2011 11:167

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  13. Content type: Research article

    The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surg...

    Authors: Jantine PosthumaDeBoer, Thomas Würdinger, Harm CA Graat, Victor W van Beusechem, Marco N Helder, Barend J van Royen and Gertjan JL Kaspers

    Citation: BMC Cancer 2011 11:156

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  14. Content type: Research article

    Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma ...

    Authors: Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler and Stephan A Hahn

    Citation: BMC Cancer 2011 11:137

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  15. Content type: Research article

    The standard treatment for patients with advanced transitional cell carcinoma of the bladder is platin based chemotherapy. Only approximately 50% of the patients respond to chemotherapy. Therefore, molecular p...

    Authors: Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft and Karin Birkenkamp-Demtroder

    Citation: BMC Cancer 2011 11:135

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  16. Content type: Research article

    CXCL12 has been widely reported to play a biologically relevant role in tumor growth and spread. In epithelial ovarian cancer (EOC), CXCL12 enhances tumor angiogenesis and contributes to the immunosuppressive ...

    Authors: Véronique Machelon, Françoise Gaudin, Sophie Camilleri-Broët, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerôme Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prévot, Philippe Broët and Karl Balabanian

    Citation: BMC Cancer 2011 11:97

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  17. Content type: Research article

    By using cDNA microarray analysis, we identified a G protein-coupled receptor, GPR39, that is significantly up-regulated in ESCC. The aim of this study is to investigate the role of GPR39 in human esophageal canc...

    Authors: Fajun Xie, Haibo Liu, Ying-Hui Zhu, Yan-Ru Qin, Yongdong Dai, Tingting Zeng, Leilei Chen, Changjun Nie, Hong Tang, Yan Li, Li Fu and Xin-Yuan Guan

    Citation: BMC Cancer 2011 11:86

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  18. Content type: Research article

    Cancer stem cells (CSCs) play an important role in the development and recurrence of malignant tumors including glioma. Notch signaling, an evolutionarily conserved pathway mediating direct cell-cell interacti...

    Authors: Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu and Hua Han

    Citation: BMC Cancer 2011 11:82

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  19. Content type: Research article

    Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and...

    Authors: Jette Bornholdt, Stine Friis, Sine Godiksen, Steen S Poulsen, Eric Santoni-Rugiu, Hanne C Bisgaard, Inger MB Lothe, Tone Ikdahl, Kjell M Tveit, Egil Johnson, Elin H Kure and Lotte K Vogel

    Citation: BMC Cancer 2011 11:65

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  20. Content type: Research article

    Oncolytic virotherapy for cancer treatment utilizes viruses for selective infection and death of cancer cells without any adverse effect on normal cells. We previously reported that the human respiratory syncy...

    Authors: Ibtissam Echchgadda, Te-Hung Chang, Ahmed Sabbah, Imad Bakri, Yuji Ikeno, Gene B Hubbard, Bandana Chatterjee and Santanu Bose

    Citation: BMC Cancer 2011 11:43

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  21. Content type: Research article

    The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development. More recently, SOX2 was shown to participate in...

    Authors: Claudia Lengerke, Tanja Fehm, Ralf Kurth, Hans Neubauer, Veit Scheble, Friederike Müller, Friederike Schneider, Karen Petersen, Diethelm Wallwiener, Lothar Kanz, Falko Fend, Sven Perner, Petra M Bareiss and Annette Staebler

    Citation: BMC Cancer 2011 11:42

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  22. Content type: Research article

    rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's ...

    Authors: Caroline MM van Geelen, Bodvael Pennarun, Phuong TK Le, Elisabeth GE de Vries and Steven de Jong

    Citation: BMC Cancer 2011 11:39

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  23. Content type: Research article

    The DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction...

    Authors: Marta Brell, Javier Ibáñez and Avelina Tortosa

    Citation: BMC Cancer 2011 11:35

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  24. Content type: Research article

    Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, whi...

    Authors: Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken and Roderich E Schwarz

    Citation: BMC Cancer 2011 11:15

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  25. Content type: Research article

    Carbonic anhydrase IX (CAIX) is a membranous expressed metalloenzyme involved in pH homeostasis and cell adhesion. The protein is overexpressed in a variety of tumors and potentially associated with negative o...

    Authors: Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller and Maike Ihnen

    Citation: BMC Cancer 2011 11:12

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  26. Content type: Research article

    iASPP is a key inhibitor of tumour suppressor p53 and is found to be up-regulated in certain malignant conditions. The present study investigated the expression of iASPP in clinical lung cancer, a leading canc...

    Authors: Jinfeng Chen, Fei Xie, Lijian Zhang and Wen G Jiang

    Citation: BMC Cancer 2010 10:694

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  27. Content type: Research article

    Targeting tumor vasculature is a strategy with great promise in the treatment of many cancers. However, anti-angiogenic reagents that target VEGF/VEGFR2 signaling have met with variable results clinically. Amo...

    Authors: Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski and Brenda L Coomber

    Citation: BMC Cancer 2010 10:683

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  28. Content type: Research article

    Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Stud...

    Authors: Erika Ginsburg, Stefanie Alexander, Sarah Lieber, Sarah Tarplin, Luwanda Jenkins, Linda Pang, Christopher D Heger, Paul Goldsmith and Barbara K Vonderhaar

    Citation: BMC Cancer 2010 10:678

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  29. Content type: Research article

    Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer ce...

    Authors: Uffe H Olesen, Jakob G Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette K Christensen, Peter Fristrup, Annemette V Thougaard, Fredrik Björkling, Peter B Jensen, Søren J Nielsen and Maxwell Sehested

    Citation: BMC Cancer 2010 10:677

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  30. Content type: Research article

    A novel series of methylene-substituted DIMs (C-DIMs), namely 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing t-butyl (DIM-C-pPhtBu) and phenyl (DIM-C-pPhC6H5) groups inhibit proliferation of i...

    Authors: Kathy Vanderlaag, Yunpeng Su, Arthur E Frankel, Robert C Burghardt, Rola Barhoumi, Gayathri Chadalapaka, Indira Jutooru and Stephen Safe

    Citation: BMC Cancer 2010 10:669

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  31. Content type: Research article

    Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncoge...

    Authors: Christina Hackl, Sven A Lang, Christian Moser, Akira Mori, Stefan Fichtner-Feigl, Claus Hellerbrand, Wolfgang Dietmeier, Hans J Schlitt, Edward K Geissler and Oliver Stoeltzing

    Citation: BMC Cancer 2010 10:668

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  32. Content type: Research article

    The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence m...

    Authors: Muzafar A Macha, Ajay Matta, SS Chauhan, KW Michael Siu and Ranju Ralhan

    Citation: BMC Cancer 2010 10:655

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  33. Content type: Research article

    The peroxisome proliferator activated receptor (PPAR) subgroup of the nuclear hormone receptor superfamily is activated by a variety of natural and synthetic ligands. PPARs can heterodimerize with retinoid X r...

    Authors: Ji Seung Han and David L Crowe

    Citation: BMC Cancer 2010 10:629

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  34. Content type: Research article

    MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31) is obviously up-regulated in col...

    Authors: Chao-Jie Wang, Johannes Stratmann, Zong-Guang Zhou and Xiao-Feng Sun

    Citation: BMC Cancer 2010 10:616

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  35. Content type: Research article

    Pancreatic cancer is the fourth leading cause of death in the US. Unlike other solid tumors such as testicular cancer which are now curable, more than 90% of pancreatic cancer patients die due to lack of respo...

    Authors: Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt and Jian-Ting Zhang

    Citation: BMC Cancer 2010 10:598

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  36. Content type: Research article

    Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mi...

    Authors: Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn and Pirkko L Härkönen

    Citation: BMC Cancer 2010 10:596

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  37. Content type: Research article

    Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-exp...

    Authors: Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei and Takashi Tamiya

    Citation: BMC Cancer 2010 10:593

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  38. Content type: Research article

    Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...

    Authors: William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen and Zijie Sun

    Citation: BMC Cancer 2010 10:556

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  39. Content type: Research article

    Many chemotherapeutic agents promote tumor cell death by activating the intrinsic pathway of apoptosis. Intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cyto...

    Authors: Sheila J Semaan and Robert W Nickells

    Citation: BMC Cancer 2010 10:554

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  40. Content type: Research article

    Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their expression is related ...

    Authors: Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix and Jelena Anacker

    Citation: BMC Cancer 2010 10:553

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  41. Content type: Research article

    MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.

    Authors: Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang and Xiao-chun Xu

    Citation: BMC Cancer 2010 10:542

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  42. Content type: Research article

    Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an importan...

    Authors: Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang and Heather E Kleiner-Hancock

    Citation: BMC Cancer 2010 10:540

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  43. Content type: Research article

    Accurate evaluation of human epidermal growth factor receptor type-2 (HER2) status based on core needle biopsy (CNB) specimens is mandatory for identification of patients with primary breast cancer who will be...

    Authors: Hitoshi Tsuda, Masafumi Kurosumi, Shinobu Umemura, Sohei Yamamoto, Takayuki Kobayashi and Robert Yoshiyuki Osamura

    Citation: BMC Cancer 2010 10:534

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  44. Content type: Research article

    cis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell cytosol. The resulting intracellular acidification s...

    Authors: Emilia Peuhu, Aura Kaunisto, Jarmo K Laihia, Lasse Leino and John E Eriksson

    Citation: BMC Cancer 2010 10:521

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  45. Content type: Research article

    There is an insufficient number of reliable prognostic and response predictive biomarkers in colorectal cancer (CRC) management. In a previous study, we found that high tumour tissue expression of tumour-assoc...

    Authors: Alexander Gaber, Björn Nodin, Kristina Hotakainen, Elise Nilsson, Ulf-Håkan Stenman, Anders Bjartell, Helgi Birgisson and Karin Jirström

    Citation: BMC Cancer 2010 10:498

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  46. Content type: Research article

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression mic...

    Authors: Jennifer A Byrne, Sanaz Maleki, Jayne R Hardy, Brian S Gloss, Rajmohan Murali, James P Scurry, Susan Fanayan, Catherine Emmanuel, Neville F Hacker, Robert L Sutherland, Anna deFazio and Philippa M O'Brien

    Citation: BMC Cancer 2010 10:497

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  47. Content type: Research article

    Overexpression of sphingosine kinase-1 (SPHK1) has been demonstrated to be associated with the development and progression in various types of human cancers. The current study was to characterize the expressio...

    Authors: Guanglin Liu, Haiqing Zheng, Zhibing Zhang, Zhiqiang Wu, Huaping Xiong, Jun Li and Libing Song

    Citation: BMC Cancer 2010 10:495

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  48. Content type: Research article

    New drugs are constantly sought after to improve the survival of patients with malignant gliomas. The ideal substance would selectively target tumor cells without eliciting toxic side effects. Here, we report ...

    Authors: Christian Senft, Margareth Polacin, Maike Priester, Volker Seifert, Donat Kögel and Jakob Weissenberger

    Citation: BMC Cancer 2010 10:491

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