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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, whi...

    Authors: Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken and Roderich E Schwarz

    Citation: BMC Cancer 2011 11:15

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  2. Content type: Research article

    Carbonic anhydrase IX (CAIX) is a membranous expressed metalloenzyme involved in pH homeostasis and cell adhesion. The protein is overexpressed in a variety of tumors and potentially associated with negative o...

    Authors: Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller and Maike Ihnen

    Citation: BMC Cancer 2011 11:12

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  3. Content type: Research article

    iASPP is a key inhibitor of tumour suppressor p53 and is found to be up-regulated in certain malignant conditions. The present study investigated the expression of iASPP in clinical lung cancer, a leading canc...

    Authors: Jinfeng Chen, Fei Xie, Lijian Zhang and Wen G Jiang

    Citation: BMC Cancer 2010 10:694

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  4. Content type: Research article

    Targeting tumor vasculature is a strategy with great promise in the treatment of many cancers. However, anti-angiogenic reagents that target VEGF/VEGFR2 signaling have met with variable results clinically. Amo...

    Authors: Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski and Brenda L Coomber

    Citation: BMC Cancer 2010 10:683

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  5. Content type: Research article

    Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Stud...

    Authors: Erika Ginsburg, Stefanie Alexander, Sarah Lieber, Sarah Tarplin, Luwanda Jenkins, Linda Pang, Christopher D Heger, Paul Goldsmith and Barbara K Vonderhaar

    Citation: BMC Cancer 2010 10:678

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  6. Content type: Research article

    Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer ce...

    Authors: Uffe H Olesen, Jakob G Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette K Christensen, Peter Fristrup, Annemette V Thougaard, Fredrik Björkling, Peter B Jensen, Søren J Nielsen and Maxwell Sehested

    Citation: BMC Cancer 2010 10:677

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  7. Content type: Research article

    Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncoge...

    Authors: Christina Hackl, Sven A Lang, Christian Moser, Akira Mori, Stefan Fichtner-Feigl, Claus Hellerbrand, Wolfgang Dietmeier, Hans J Schlitt, Edward K Geissler and Oliver Stoeltzing

    Citation: BMC Cancer 2010 10:668

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  8. Content type: Research article

    A novel series of methylene-substituted DIMs (C-DIMs), namely 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing t-butyl (DIM-C-pPhtBu) and phenyl (DIM-C-pPhC6H5) groups inhibit proliferation of i...

    Authors: Kathy Vanderlaag, Yunpeng Su, Arthur E Frankel, Robert C Burghardt, Rola Barhoumi, Gayathri Chadalapaka, Indira Jutooru and Stephen Safe

    Citation: BMC Cancer 2010 10:669

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  9. Content type: Research article

    The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence m...

    Authors: Muzafar A Macha, Ajay Matta, SS Chauhan, KW Michael Siu and Ranju Ralhan

    Citation: BMC Cancer 2010 10:655

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  10. Content type: Research article

    The peroxisome proliferator activated receptor (PPAR) subgroup of the nuclear hormone receptor superfamily is activated by a variety of natural and synthetic ligands. PPARs can heterodimerize with retinoid X r...

    Authors: Ji Seung Han and David L Crowe

    Citation: BMC Cancer 2010 10:629

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  11. Content type: Research article

    MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31) is obviously up-regulated in col...

    Authors: Chao-Jie Wang, Johannes Stratmann, Zong-Guang Zhou and Xiao-Feng Sun

    Citation: BMC Cancer 2010 10:616

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  12. Content type: Research article

    Pancreatic cancer is the fourth leading cause of death in the US. Unlike other solid tumors such as testicular cancer which are now curable, more than 90% of pancreatic cancer patients die due to lack of respo...

    Authors: Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt and Jian-Ting Zhang

    Citation: BMC Cancer 2010 10:598

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  13. Content type: Research article

    Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mi...

    Authors: Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn and Pirkko L Härkönen

    Citation: BMC Cancer 2010 10:596

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  14. Content type: Research article

    Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-exp...

    Authors: Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei and Takashi Tamiya

    Citation: BMC Cancer 2010 10:593

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  15. Content type: Research article

    Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...

    Authors: William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen and Zijie Sun

    Citation: BMC Cancer 2010 10:556

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  16. Content type: Research article

    Many chemotherapeutic agents promote tumor cell death by activating the intrinsic pathway of apoptosis. Intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cyto...

    Authors: Sheila J Semaan and Robert W Nickells

    Citation: BMC Cancer 2010 10:554

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  17. Content type: Research article

    Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their expression is related ...

    Authors: Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix and Jelena Anacker

    Citation: BMC Cancer 2010 10:553

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  18. Content type: Research article

    MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.

    Authors: Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang and Xiao-chun Xu

    Citation: BMC Cancer 2010 10:542

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  19. Content type: Research article

    Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an importan...

    Authors: Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang and Heather E Kleiner-Hancock

    Citation: BMC Cancer 2010 10:540

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  20. Content type: Research article

    Accurate evaluation of human epidermal growth factor receptor type-2 (HER2) status based on core needle biopsy (CNB) specimens is mandatory for identification of patients with primary breast cancer who will be...

    Authors: Hitoshi Tsuda, Masafumi Kurosumi, Shinobu Umemura, Sohei Yamamoto, Takayuki Kobayashi and Robert Yoshiyuki Osamura

    Citation: BMC Cancer 2010 10:534

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  21. Content type: Research article

    cis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell cytosol. The resulting intracellular acidification s...

    Authors: Emilia Peuhu, Aura Kaunisto, Jarmo K Laihia, Lasse Leino and John E Eriksson

    Citation: BMC Cancer 2010 10:521

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  22. Content type: Research article

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression mic...

    Authors: Jennifer A Byrne, Sanaz Maleki, Jayne R Hardy, Brian S Gloss, Rajmohan Murali, James P Scurry, Susan Fanayan, Catherine Emmanuel, Neville F Hacker, Robert L Sutherland, Anna deFazio and Philippa M O'Brien

    Citation: BMC Cancer 2010 10:497

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  23. Content type: Research article

    There is an insufficient number of reliable prognostic and response predictive biomarkers in colorectal cancer (CRC) management. In a previous study, we found that high tumour tissue expression of tumour-assoc...

    Authors: Alexander Gaber, Björn Nodin, Kristina Hotakainen, Elise Nilsson, Ulf-Håkan Stenman, Anders Bjartell, Helgi Birgisson and Karin Jirström

    Citation: BMC Cancer 2010 10:498

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  24. Content type: Research article

    Overexpression of sphingosine kinase-1 (SPHK1) has been demonstrated to be associated with the development and progression in various types of human cancers. The current study was to characterize the expressio...

    Authors: Guanglin Liu, Haiqing Zheng, Zhibing Zhang, Zhiqiang Wu, Huaping Xiong, Jun Li and Libing Song

    Citation: BMC Cancer 2010 10:495

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  25. Content type: Research article

    New drugs are constantly sought after to improve the survival of patients with malignant gliomas. The ideal substance would selectively target tumor cells without eliciting toxic side effects. Here, we report ...

    Authors: Christian Senft, Margareth Polacin, Maike Priester, Volker Seifert, Donat Kögel and Jakob Weissenberger

    Citation: BMC Cancer 2010 10:491

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  26. Content type: Research article

    Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices. The present study has focussed on S100 proteins as a p...

    Authors: Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz and Ida Pucci-Minafra

    Citation: BMC Cancer 2010 10:476

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  27. Content type: Research article

    Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We aimed to determine whether inhibitors of differentiation 1 (Id1) were expressed in circulating EPCs of patients with ovarian ...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Jie Bao, Zhen Cai and Ailan Liu

    Citation: BMC Cancer 2010 10:459

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  28. Content type: Research article

    Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical tri...

    Authors: Jan N Kreutzer, Maria Ruzzene and Barbara Guerra

    Citation: BMC Cancer 2010 10:440

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  29. Content type: Research article

    In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mec...

    Authors: Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa and Akio Yamaguchi

    Citation: BMC Cancer 2010 10:443

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  30. Content type: Research article

    Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment in many cancer types. However, the significance of NF-κB pathway for compl...

    Authors: Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang and Wan-tao Chen

    Citation: BMC Cancer 2010 10:437

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  31. Content type: Research article

    We investigated the distribution and clinical significance of mobilized endothelial progenitor cells (EPCs) in hepatocellular carcinoma (HCC). We found that many more EPCs were recruited to nonmalignant liver ...

    Authors: De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang and Yi-tao Ding

    Citation: BMC Cancer 2010 10:435

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  32. Content type: Research article

    Chloroquine (CQ), the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. It has been sh...

    Authors: Kazuhito Sasaki, Nelson H Tsuno, Eiji Sunami, Giichiro Tsurita, Kazushige Kawai, Yurai Okaji, Takeshi Nishikawa, Yasutaka Shuno, Kumiko Hongo, Masaya Hiyoshi, Manabu Kaneko, Joji Kitayama, Koki Takahashi and Hirokazu Nagawa

    Citation: BMC Cancer 2010 10:370

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  33. Content type: Research article

    Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We h...

    Authors: Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari and Caroline A Lamb

    Citation: BMC Cancer 2010 10:293

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