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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Thrombospondin (TSP) is a multi-functional protein that appears to have dual roles in cancer, that is, either as a promoter or a suppressor. 4N1K is a TSP-derived peptide that has been reported to be associate...

    Authors: Yasuyoshi Miyata, Shin-ichi Watanabe, Hiroshi Kanetake and Hideki Sakai

    Citation: BMC Cancer 2012 12:372

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  2. Content type: Research article

    Alterations of mTOR gene expression have been implicated in the pathogenesis of endometrioid endometrial cancer however only few studies explored the cause of increased mTOR activation in this malignancy. miRN...

    Authors: Anna Torres, Kamil Torres, Anna Pesci, Marcello Ceccaroni, Tomasz Paszkowski, Paola Cassandrini, Giuseppe Zamboni and Ryszard Maciejewski

    Citation: BMC Cancer 2012 12:369

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  3. Content type: Research article

    AMP-activated protein kinase (AMPK) has recently been considered as a potential target for cancer therapy. However, the expression status of various subunits of the heterotrimeric AMPK in human cancers is rarely...

    Authors: Cuilan Li, Vincent WS Liu, Pui M Chiu, David W Chan and Hextan YS Ngan

    Citation: BMC Cancer 2012 12:357

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  4. Content type: Research article

    BRCA1 (B), ERCC1 (E), RRM1 (R) and TYMS (T) mRNA expression has been extensively studied with respect to NSCLC patient outcome upon various chemotherapy agents. However, these markers have not been introduced ...

    Authors: Vassiliki Kotoula, Dimitrios Krikelis, Vasilios Karavasilis, Triantafillia Koletsa, Anastasia G Eleftheraki, Despina Televantou, Christos Christodoulou, Stefanos Dimoudis, Ippokratis Korantzis, Dimitrios Pectasides, Konstantinos N Syrigos, Paris A Kosmidis and George Fountzilas

    Citation: BMC Cancer 2012 12:342

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  5. Content type: Research article

    Resistance to apoptosis is a hallmark of cancer and proteins regulating apoptosis have been proposed as prognostic markers in several malignancies. However, the prognostic impact of apoptotic markers has not b...

    Authors: Pinaki Bose, Alexander C Klimowicz, Elizabeth Kornaga, Stephanie K Petrillo, T Wayne Matthews, Shamir Chandarana, Anthony M Magliocco, Nigel T Brockton and Joseph C Dort

    Citation: BMC Cancer 2012 12:332

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  6. Content type: Research article

    Aldehyde dehydrogenases belong to a superfamily of detoxifying enzymes that protect cells from carcinogenic aldehydes. Of the superfamily, ALDH1A1 has gained most attention because current studies have shown t...

    Authors: Yu-Ting Saw, Junzheng Yang, Shu-Kay Ng, Shubai Liu, Surendra Singh, Margit Singh, William R Welch, Hiroshi Tsuda, Wing-Ping Fong, David Thompson, Vasilis Vasiliou, Ross S Berkowitz and Shu-Wing Ng

    Citation: BMC Cancer 2012 12:329

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  7. Content type: Research article

    The NeoAzure study has demonstrated that the use of the bisphosphonate zoledronic acid (Zol) in the neoadjuvant setting increases the rate of complete response in primary breast cancer and therefore indicates ...

    Authors: Tanja Fehm, Manfred Zwirner, Diethelm Wallwiener, Harald Seeger and Hans Neubauer

    Citation: BMC Cancer 2012 12:308

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  8. Content type: Technical advance

    Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and ant...

    Authors: Ulrike Weissenstein, Agnes Schumann, Marcus Reif, Susanne Link, Ulrike D Toffol-Schmidt and Peter Heusser

    Citation: BMC Cancer 2012 12:206

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  9. Content type: Research article

    To investigate the prognostic significance of disseminated tumor cells (DTCs) in bone marrow (BM) from non-metastatic breast cancer patients before and after surgery.

    Authors: Kjersti Tjensvoll, Satu Oltedal, Reino Heikkilä, Jan Terje Kvaløy, Bjørnar Gilje, James M Reuben, Rune Smaaland and Oddmund Nordgård

    Citation: BMC Cancer 2012 12:190

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  10. Content type: Research article

    Clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer is controversial. Here, we used a tumor microarray including a large series of ductal and lobular breast cancers with long term foll...

    Authors: Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli and Coya Tapia

    Citation: BMC Cancer 2012 12:134

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  11. Content type: Research article

    Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to...

    Authors: Hidekazu Kuramochi, Go Nakajima, Yuka Kaneko, Ayako Nakamura, Yuji Inoue, Masakazu Yamamoto and Kazuhiko Hayashi

    Citation: BMC Cancer 2012 12:88

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  12. Content type: Research article

    The dyslexia candidate gene, DYX1C1, shown to regulate and interact with estrogen receptors and involved in the regulation of neuronal migration, has recently been proposed as a putative cancer biomarker. This st...

    Authors: Gustaf Rosin, Ulf Hannelius, Linda Lindström, Per Hall, Jonas Bergh, Johan Hartman and Juha Kere

    Citation: BMC Cancer 2012 12:79

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  13. Content type: Research article

    The clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its r...

    Authors: Annica Holmqvist, Jingfang Gao, Birgitta Holmlund, Gunnar Adell, John Carstensen, Dianne Langford and Xiao-Feng Sun

    Citation: BMC Cancer 2012 12:65

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  14. Content type: Research article

    Colorectal cancer is the third most common cancer and the third leading cause of cancer-related death. Bevacizumab is a humanized monoclonal antibody developed against vascular endothelial growth factor (VEGF)...

    Authors: Atil Bisgin, Aysegul Kargi, Arzu D Yalcin, Cigdem Aydin, Deniz Ekinci, Burhan Savas and Salih Sanlioglu

    Citation: BMC Cancer 2012 12:58

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  15. Content type: Research article

    Although fibroblast growth factor 19 (FGF19) can promote liver carcinogenesis in mice, its involvement in human hepatocellular carcinoma (HCC) has not been well investigated. FGF19, a member of the FGF family,...

    Authors: Seiki Miura, Noboru Mitsuhashi, Hiroaki Shimizu, Fumio Kimura, Hiroyuki Yoshidome, Masayuki Otsuka, Atsushi Kato, Takashi Shida, Daiki Okamura and Masaru Miyazaki

    Citation: BMC Cancer 2012 12:56

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  16. Content type: Research article

    Herein we present the results of two related investigations. The first study determined if concentrations in breast nipple discharge (ND) of two proteins (urinary plasminogen activator, uPA and its inhibitor, ...

    Authors: Wenyi Qin, Gerald Gui, Ke Zhang, Dominique Twelves, Beth Kliethermes and Edward R Sauter

    Citation: BMC Cancer 2012 12:52

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  17. Content type: Research article

    miRNAs, endogenous oligonucleotide RNAs, play an important role in mammary gland carcinogenesis and tumor progression. Detection of their expression and investigation of their functions could lead to discovery...

    Authors: Zheng-sheng Wu, Chao-qun Wang, Ru Xiang, Xue Liu, Shan Ye, Xue-qing Yang, Gui-hong Zhang, Xiao-chun Xu, Tao Zhu and Qiang Wu

    Citation: BMC Cancer 2012 12:51

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  18. Content type: Research article

    In estrogen responsive MCF-7 cells, estradiol (E2) binding to ERα leads to transcriptional regulation of genes involved in the control of cell proliferation and survival. MicroRNAs (miRNAs) have emerged as key po...

    Authors: Xinfeng Yu, Xuemei Zhang, Ishwori B Dhakal, Marjorie Beggs, Susan Kadlubar and Dali Luo

    Citation: BMC Cancer 2012 12:29

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  19. Content type: Research article

    Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an immune response. We examined tumor expression and prog...

    Authors: Esther M de Kruijf, Anita Sajet, Johanna GH van Nes, Hein Putter, Vincent THBM Smit, Robert A Eagle, Insiya Jafferji, John Trowsdale, Gerrit Jan Liefers, Cornelis JH van de Velde and Peter JK Kuppen

    Citation: BMC Cancer 2012 12:24

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  20. Content type: Research article

    There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic revie...

    Authors: Ying Zhou, Xin Yin, Jun Ying and BoHeng Zhang

    Citation: BMC Cancer 2012 12:17

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  21. Content type: Research article

    An influence of gonadotropins (hCG) on the development of ovarian cancer has been discussed. Therefore, we quantified serum hCG levels in patients with benign and malignant ovarian tumors and the hCG expressio...

    Authors: Miriam Lenhard, Alexandra Tsvilina, Lan Schumacher, Markus Kupka, Nina Ditsch, Doris Mayr, Klaus Friese and Udo Jeschke

    Citation: BMC Cancer 2012 12:2

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  22. Content type: Research article

    The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, ...

    Authors: Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner and Andreas Jung

    Citation: BMC Cancer 2011 11:518

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  23. Content type: Research article

    Five-year survival for lung cancer has remained at 16% over last several decades largely due to the fact that over 50% of patients are diagnosed with locally-advanced or metastatic disease. Diagnosis at an ear...

    Authors: Elena Kupert, Marshall Anderson, Yin Liu, Paul Succop, Linda Levin, Jiang Wang, Kathryn Wikenheiser-brokamp, Pingping Chen, Susan M Pinney, Trudy Macdonald, Zhongyun Dong, Sandra Starnes and Shan Lu

    Citation: BMC Cancer 2011 11:513

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  24. Content type: Research article

    There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor prognosis in patients with advanced cancers. We evaluated the relationships between clinical ...

    Authors: Jun-Eul Hwang, Ha-Na Kim, Dae-Eun Kim, Hyun-Jung Choi, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Sang-Hee Cho and Ik-Joo Chung

    Citation: BMC Cancer 2011 11:489

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  25. Content type: Research article

    The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of predicting a pCR, such as the proliferation...

    Authors: Peter A Fasching, Katharina Heusinger, Lothar Haeberle, Melitta Niklos, Alexander Hein, Christian M Bayer, Claudia Rauh, Ruediger Schulz-Wendtland, Mayada R Bani, Michael Schrauder, Laura Kahmann, Michael P Lux, Johanna D Strehl, Arndt Hartmann, Arno Dimmler, Matthias W Beckmann…

    Citation: BMC Cancer 2011 11:486

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  26. Content type: Research article

    The polycomb transcription factor Yin Yang 1 (YY1) overexpression can be causally implicated in experimental tumor growth and metastasization. To date, there is no clinical evidence of YY1 involvement in outco...

    Authors: Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini and Claudio Napoli

    Citation: BMC Cancer 2011 11:472

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  27. Content type: Research article

    Human leukocyte antigen (HLA)-class I molecules on tumor cells have been regarded as crucial sites where cytotoxic T lymphocytes (CTL) can recognize tumor-specific antigens and are strongly associated with ant...

    Authors: Koichi Kaneko, Sumiya Ishigami, Yuko Kijima, Yawara Funasako, Munetsugu Hirata, Hiroshi Okumura, Hiroyuki Shinchi, Chihaya Koriyama, Shinichi Ueno, Heiji Yoshinaka and Shoji Natsugoe

    Citation: BMC Cancer 2011 11:454

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  28. Content type: Research article

    Clinicians often experience extrahepatic metastases associated with hepatocellular carcinoma (HCC), even if no evidence of intrahepatic recurrence after treatment is observed. We investigated the pretreatment ...

    Authors: Hyun-Mi Bae, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Kim, Dae Seog Heo and Hyo-Suk Lee

    Citation: BMC Cancer 2011 11:435

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  29. Content type: Research article

    Patient selection for phase I trials (PIT) in oncology is challenging. A typical inclusion criterion for PIT is 'life expectancy > 3 months', however the 90 day mortality (90DM) and overall survival (OS) of pa...

    Authors: Nicole G Chau, Ana Florescu, Kelvin K Chan, Lisa Wang, Eric X Chen, Philippe Bedard, Amit M Oza and Lillian L Siu

    Citation: BMC Cancer 2011 11:426

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  30. Content type: Research article

    The molecular mechanisms involved in the development and progression of clear cell renal cell carcinomas (ccRCCs) are poorly understood. The objective of this study was to analyze the expression of dual-specif...

    Authors: Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai and Fangjian Zhou

    Citation: BMC Cancer 2011 11:413

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  31. Content type: Research article

    P21(WAF1/Cip1) binds to cyclin-dependent kinase complexes and inhibits their activities. It was originally described as an inhibitor of cancer cell proliferation. However, many recent studies have shown that p21 ...

    Authors: Xi Xia, Quanfu Ma, Xiao Li, Teng Ji, Pingbo Chen, Hongbin Xu, Kezhen Li, Yong Fang, Danhui Weng, Yanjie Weng, Shujie Liao, Zhiqiang Han, Ronghua Liu, Tao Zhu, Shixuan Wang, Gang Xu…

    Citation: BMC Cancer 2011 11:399

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  32. Content type: Research article

    Overexpression of carbonic anhydrase (CA IX) is associated with poor survival in several adult-type cancers but its expression is undocumented in Wilms tumour (WT), the most common tumour of the paediatric kid...

    Authors: Josiah V Dungwa, Linda P Hunt and Pramila Ramani

    Citation: BMC Cancer 2011 11:390

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  33. Content type: Research article

    Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lun...

    Authors: Jun Shen, Ziling Liu, Nevins W Todd, Howard Zhang, Jipei Liao, Lei Yu, Maria A Guarnera, Ruiyun Li, Ling Cai, Min Zhan and Feng Jiang

    Citation: BMC Cancer 2011 11:374

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  34. Content type: Research article

    For patients with locally advanced rectal cancer (LARC) neoadjuvant chemoradiotherapy is recommended as standard therapy. So far, no predictive or prognostic molecular factors for patients undergoing multimoda...

    Authors: Juliana Schwaab, Karoline Horisberger, Philipp Ströbel, Beatrice Bohn, Deniz Gencer, Georg Kähler, Peter Kienle, Stefan Post, Frederik Wenz, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz and Philipp Erben

    Citation: BMC Cancer 2011 11:363

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  35. Content type: Research article

    Epithelial-mesenchymal transition (EMT) is a crucial process in tumorigenesis since tumor cells attain fibroblast-like features enabling them to invade to surrounding tissue. Two transcription factors, TWIST and

    Authors: Anna Jouppila-Mättö, Mervi Närkiö-Mäkelä, Ylermi Soini, Matti Pukkila, Reijo Sironen, Hanna Tuhkanen, Arto Mannermaa and Veli-Matti Kosma

    Citation: BMC Cancer 2011 11:350

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  36. Content type: Research article

    Breast cancer consists of a variety of tumours, which differ by their morphological features, molecular characteristics and outcome. Well-known prognostic factors, e.g. tumour grade and size, Ki-67, hormone re...

    Authors: Pia Boström, Mirva Söderström, Tero Vahlberg, Karl-Ove Söderström, Peter J Roberts, Olli Carpén and Pirkko Hirsimäki

    Citation: BMC Cancer 2011 11:348

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  37. Content type: Research article

    Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary colorectal cancer (CRC) (n = 162) and liver metas...

    Authors: Johannes Stratmann, Chao-Jie Wang, Sebastian Gnosa, Åsa Wallin, David Hinselwood, Xiao-Feng Sun and Hong Zhang

    Citation: BMC Cancer 2011 11:345

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  38. Content type: Research article

    An increasing number of neo-adjuvant breast cancer studies are being conducted and a novel model for tumor biological studies, the "window-of-opportunity" model, has revealed several advantages. Change in tumo...

    Authors: Quinci Romero, Pär-Ola Bendahl, Marie Klintman, Niklas Loman, Christian Ingvar, Lisa Rydén, Carsten Rose, Dorthe Grabau and Signe Borgquist

    Citation: BMC Cancer 2011 11:341

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  39. Content type: Research article

    CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various ca...

    Authors: Yoon Ho Ko, Hye Sung Won, Eun Kyoung Jeon, Sook Hee Hong, Sang Young Roh, Young Seon Hong, Jae Ho Byun, Chan-Kwon Jung and Jin Hyoung Kang

    Citation: BMC Cancer 2011 11:340

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  40. Content type: Research article

    Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are...

    Authors: Seok Jin Kim, Chul Won Choi, Yeung-Chul Mun, Sung Yong Oh, Hye Jin Kang, Soon Il Lee, Jong Ho Won, Min Kyoung Kim, Jung Hye Kwon, Jin Seok Kim, Jae-Yong Kwak, Jung Mi Kwon, In Gyu Hwang, Hyo Jung Kim, Jae Hoon Lee, Sukjoong Oh…

    Citation: BMC Cancer 2011 11:321

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  41. Content type: Research article

    Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the rol...

    Authors: Nelma Pértega-Gomes, José R Vizcaíno, Vera Miranda-Gonçalves, Céline Pinheiro, Joana Silva, Helena Pereira, Pedro Monteiro, Rui M Henrique, Rui M Reis, Carlos Lopes and Fátima Baltazar

    Citation: BMC Cancer 2011 11:312

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  42. Content type: Research article

    Fatty acid binding proteins (FABP) play an important role in carcinogenesis. Modified FABP expression patterns were described for prostate, bladder and for renal cell carcinoma. Studies on metabolic relationsh...

    Authors: Angelika Tölle, Saba Suhail, Monika Jung, Klaus Jung and Carsten Stephan

    Citation: BMC Cancer 2011 11:302

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  43. Content type: Research article

    In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting. Methods: In this study we investigated EGFR expression a...

    Authors: Aurelia Noske, Michael Schwabe, Wilko Weichert, Silvia Darb-Esfahani, Ann-Christin Buckendahl, Jalid Sehouli, Elena I Braicu, Jan Budczies, Manfred Dietel and Carsten Denkert

    Citation: BMC Cancer 2011 11:294

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  44. Content type: Research article

    Molecular classification of breast cancer is an important prognostic factor. The distribution of molecular subtypes of breast cancer and their prognostic value has not been well documented in Asians.

    Authors: Yinghao Su, Ying Zheng, Wei Zheng, Kai Gu, Zhi Chen, Guoliang Li, Qiuyin Cai, Wei Lu and Xiao Ou Shu

    Citation: BMC Cancer 2011 11:292

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  45. Content type: Research article

    The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pan...

    Authors: Nuh N Rahbari, Thomas Schmidt, Christine S Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W Büchler, Jürgen Weitz and Moritz Koch

    Citation: BMC Cancer 2011 11:286

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  46. Content type: Research article

    Aldehyde deyhdrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours. Additionally, it plays a pivotal role in gene regulation and endows tumour cells with augment...

    Authors: Christoph Kahlert, Frank Bergmann, Janine Beck, Thilo Welsch, Carolin Mogler, Esther Herpel, Shamik Dutta, Thomas Niemietz, Moritz Koch and Jürgen Weitz

    Citation: BMC Cancer 2011 11:275

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  47. Content type: Research article

    Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the re...

    Authors: Qing Wang, Ye-xiong Tan, Yi-bin Ren, Li-wei Dong, Zhi-fang Xie, Liang Tang, Dan Cao, Wei-ping Zhang, He-ping Hu and Hong-yang Wang

    Citation: BMC Cancer 2011 11:271

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  48. Content type: Research article

    Myofibrillogenesis regulator 1 (MR-1) is overexpressed in human cancer cells and plays an essential role in cancer cell growth. However, the significance of MR-1 in human ovarian cancer has not yet been explor...

    Authors: Renquan Lu, Min Sun, Jingjing Feng, Xiang Gao and Lin Guo

    Citation: BMC Cancer 2011 11:270

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