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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    Nasopharyngeal carcinoma (NPC) is a highly metastatic epithelial malignancy showing high prevalence in Southeast Asia and North Africa. The BCL2-associated X (BAX) gene encodes the most important pro-apoptotic me...

    Authors: Christos K Kontos, Ali Fendri, Abdelmajid Khabir, Raja Mokdad-Gargouri and Andreas Scorilas

    Citation: BMC Cancer 2013 13:293

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  2. Content type: Research article

    As the incidence of prostate cancer continues to rise steeply, there is an increasing need to identify more accurate prognostic markers for the disease. There is some evidence that a higher modified Glasgow Pr...

    Authors: Kashif Shafique, Michael J Proctor, Donald C McMillan, Hing Leung, Karen Smith, Billy Sloan and David S Morrison

    Citation: BMC Cancer 2013 13:292

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  3. Content type: Research article

    Accumulating evidence supports cancer to initiate and develop from a small population of stem-like cells termed as cancer stem cells (CSC). The exact phenotype of CSC and their counterparts in normal mammary g...

    Authors: Hazem Ghebeh, Ghida Majed Sleiman, Pulicat S Manogaran, Amer Al-Mazrou, Eman Barhoush, Falah H Al-Mohanna, Asma Tulbah, Khalid Al-Faqeeh and Chaker N Adra

    Citation: BMC Cancer 2013 13:289

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  4. Content type: Research article

    Vulvar squamous cell carcinoma is a cancer form with increasing incidence rate and few treatment options. Wee1 is a central regulator of the G2/M DNA-damage checkpoint, and has in previous studies been describ...

    Authors: Gry Irene Magnussen, Ellen Hellesylt, Jahn M Nesland, Claes G Trope, Vivi Ann Flørenes and Ruth Holm

    Citation: BMC Cancer 2013 13:288

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  5. Content type: Research article

    To establish a distant metastasis (DM) cells must disseminate from the primary tumor and overcome a series of obstacles, the metastatic cascade. In this study we develop a mathematical model for this cascade t...

    Authors: Frank AW Coumans, Sabine Siesling and Leon WMM Terstappen

    Citation: BMC Cancer 2013 13:283

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  6. Content type: Research article

    p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inact...

    Authors: Arantza Fariña Sarasqueta, Giusi Irma Forte, Wim E Corver, Noel F de Miranda, Dina Ruano, Ronald van Eijk, Jan Oosting, Rob AEM Tollenaar, Tom van Wezel and Hans Morreau

    Citation: BMC Cancer 2013 13:277

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  7. Content type: Research article

    Cancer–testis antigens (CTA) comprise a family of proteins, which are physiologically expressed in adult human tissues solely in testicular germ cells and occasionally placenta. However, CTA expression has bee...

    Authors: Dimitrios Balafoutas, Axel zur Hausen, Sebastian Mayer, Marc Hirschfeld, Markus Jaeger, Dominik Denschlag, Gerald Gitsch, Achim Jungbluth and Elmar Stickeler

    Citation: BMC Cancer 2013 13:271

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  8. Content type: Research article

    Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link ...

    Authors: Alex Y Chang and Miao Wang

    Citation: BMC Cancer 2013 13:267

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  9. Content type: Research article

    High serum carcinoembryonic antigen (CEA) levels are an independent prognostic factor for recurrence and survival in patients with non-small cell lung cancer (NSCLC). Its role as a predictive marker of treatme...

    Authors: Oscar Arrieta, Cynthia Villarreal-Garza, Luis Martínez-Barrera, Marcelino Morales, Yuzmiren Dorantes-Gallareta, Omar Peña-Curiel, Susana Contreras-Reyes, Eleazar Omar Macedo-Pérez and Jorge Alatorre-Alexander

    Citation: BMC Cancer 2013 13:254

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  10. Content type: Research article

    The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible f...

    Authors: Ahsan Siraj, Virginie Desestret, Martine Antoine, Gaëlle Fromont, Michel Huerre, Marc Sanson, Philippe Camparo, Christophe Pichon, François Planeix, Julie Gonin, Aurelian Radu and Nicolae Ghinea

    Citation: BMC Cancer 2013 13:246

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  11. Content type: Research article

    Chemotherapy with trastuzumab is widely used for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer, but a significant number of patients with the tumor fail to respond, or r...

    Authors: Mamoru Takada, Toru Higuchi, Katsunori Tozuka, Hiroyuki Takei, Masayuki Haruta, Junko Watanabe, Fumio Kasai, Kenichi Inoue, Masafumi Kurosumi, Masaru Miyazaki, Aiko Sato-Otsubo, Seishi Ogawa and Yasuhiko Kaneko

    Citation: BMC Cancer 2013 13:241

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  12. Content type: Research article

    High levels of circulating C-reactive protein (CRP) have recently been linked to poor clinical outcome in various malignancies. The aim of this study was to evaluate the prognostic significance of the preopera...

    Authors: Sandra Steffens, Andreas Al Ghazal, Julie Steinestel, Rieke Lehmann, Gerd Wegener, Thomas J Schnoeller, Marcus V Cronauer, Florian Jentzmik, Mark Schrader, Markus A Kuczyk and Andres J Schrader

    Citation: BMC Cancer 2013 13:223

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  13. Content type: Research article

    Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide...

    Authors: Jia-Jia Huang, Ya-Jun Li, Yi Xia, Yu Wang, Wen-Xiao Wei, Ying-Jie Zhu, Tong-Yu Lin, Hui-Qiang Huang, Wen-Qi Jiang and Zhi-Ming Li

    Citation: BMC Cancer 2013 13:222

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  14. Content type: Research article

    The incidence of Human Papillomavirus (HPV) associated oropharyngeal cancer (OPC) is increasing. HPV-associated OPC appear to have better prognosis than HPV-negative OPC. The aim of this study was to robustly ...

    Authors: Mererid Evans, Robert Newcombe, Alison Fiander, James Powell, Martin Rolles, Selvam Thavaraj, Max Robinson and Ned Powell

    Citation: BMC Cancer 2013 13:220

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  15. Content type: Research article

    Aurora A kinase, a centrosomal serine/threonine kinase which plays an essential role in chromosome segregation during cell division, is commonly amplified and/or over expressed in human malignancies. Aurora A ...

    Authors: Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Saori Fujiwara and Hirotaka Iwase

    Citation: BMC Cancer 2013 13:217

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  16. Content type: Research article

    In breast cancer, the role of epigenetic alterations including modifications of the acetylation status of histones in carcinogenesis has been an important research focus during the last years. An increased dea...

    Authors: Berit Maria Müller, Lisa Jana, Atsuko Kasajima, Annika Lehmann, Judith Prinzler, Jan Budczies, Klaus-Jürgen Winzer, Manfred Dietel, Wilko Weichert and Carsten Denkert

    Citation: BMC Cancer 2013 13:215

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  17. Content type: Research article

    Selenium has attracted attention because of its antioxidant properties. Antioxidants protects cells from damage. Certain breakdown products of selenium are believed to prevent tumor growth by enhancing the imm...

    Authors: Marcin R Lener, Satish Gupta, Rodney J Scott, Martin Tootsi, Maria Kulp, Mari-Liis Tammesoo, Anu Viitak, Anders Metspalu, Pablo Serrano-Fernández, Józef Kładny, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Anna Jakubowska and Jan Lubiński

    Citation: BMC Cancer 2013 13:214

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  18. Content type: Research article

    Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very ...

    Authors: Chiharu Tabata, Eisuke Shibata, Rie Tabata, Shingo Kanemura, Koji Mikami, Yoshitaka Nogi, Eriko Masachika, Tomoyuki Nishizaki and Takashi Nakano

    Citation: BMC Cancer 2013 13:205

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  19. Content type: Research article

    This study was initiated to investigate the prognostic significance of circulating tumor cell (CTC) enumeration and the predictive value of CTC HER2 expression for efficient anti-HER2 therapy in HER2-positive ...

    Authors: Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, Haixu Hu, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu and Zefei Jiang

    Citation: BMC Cancer 2013 13:202

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  20. Content type: Research article

    Significance of Urocortin (Ucn or UcnI), Ucn2, Ucn3 and their receptors, Corticotropin Releasing Factor Receptor 1 and 2 (CRFR1 and CRFR2), and the binding protein, Corticotropin-Releasing Hormone-Binding Prot...

    Authors: Hossein Tezval, Faranaz Atschekzei, Inga Peters, Sandra Waalkes, Jörg Hennenlotter, Arnulf Stenzl, Jan U Becker, Axel S Merseburger, Markus A Kuczyk and Jürgen Serth

    Citation: BMC Cancer 2013 13:199

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  21. Content type: Research article

    The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, ...

    Authors: Bilal Alaiyan, Nadia Ilyayev, Alexander Stojadinovic, Mina Izadjoo, Marina Roistacher, Vera Pavlov, Victoria Tzivin, David Halle, Honguang Pan, Barry Trink, Ali O Gure and Aviram Nissan

    Citation: BMC Cancer 2013 13:196

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  22. Content type: Research article

    Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma...

    Authors: Zhihua Shen, Xiaofan Jiang, Chao Zeng, Shaojiang Zheng, Botao Luo, Yumei Zeng, Ranran Ding, Hanguo Jiang, Qiyi He, Junli Guo and Wei Jie

    Citation: BMC Cancer 2013 13:192

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  23. Content type: Research article

    Hyaluronan is an extracellular matrix glycosaminoglycan involved in invasion, proliferation and metastasis of various types of carcinomas. In many cancers, aberrant hyaluronan expression implicates disease pro...

    Authors: Siiskonen Hanna, Poukka Mari, Tyynelä-Korhonen Kristiina, Sironen Reijo and Pasonen-Seppänen Sanna

    Citation: BMC Cancer 2013 13:181

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  24. Content type: Research article

    Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as ...

    Authors: Patrick C O´Leary, Sarah A Penny, Roisin T Dolan, Catherine M Kelly, Stephen F Madden, Elton Rexhepaj, Donal J Brennan, Amanda H McCann, Fredrik Pontén, Mathias Uhlén, Radoslaw Zagozdzon, Michael J Duffy, Malcolm R Kell, Karin Jirström and William M Gallagher

    Citation: BMC Cancer 2013 13:175

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  25. Content type: Research article

    The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has be...

    Authors: George Fountzilas, Urania Dafni, Mattheos Bobos, Vassiliki Kotoula, Anna Batistatou, Ioannis Xanthakis, Christos Papadimitriou, Ioannis Kostopoulos, Triantafillia Koletsa, Eleftheria Tsolaki, Despina Televantou, Eleni Timotheadou, Angelos Koutras, George Klouvas, Epaminontas Samantas, Nikolaos Pisanidis…

    Citation: BMC Cancer 2013 13:163

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  26. Content type: Research article

    Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopatholog...

    Authors: Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong and Meng-Chao Wu

    Citation: BMC Cancer 2013 13:161

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  27. Content type: Research article

    53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact wi...

    Authors: Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy and Fen Xia

    Citation: BMC Cancer 2013 13:155

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  28. Content type: Research article

    Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resi...

    Authors: Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin and Malin Sund

    Citation: BMC Cancer 2013 13:154

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  29. Content type: Research article

    Aberrant chromatin structure in cancer cells results from altered proteins involved in its packaging. Heterochromatin protein 1 gamma (HP1γ) is a non-histone heterochromatic protein that functions to maintain ...

    Authors: Jon Slezak, Matthew Truong, Wei Huang and David Jarrard

    Citation: BMC Cancer 2013 13:148

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  30. Content type: Research article

    Snail1 is a transcription regulator of E-cadherin. The loss of E-cadherin seems to be a crucial step in the process of Epithelial-mesenchymal transition (EMT). EMT initiates invasion and proliferation in many ...

    Authors: Feride Kroepil, Georg Fluegen, Daniel Vallböhmer, Stephan E Baldus, Levent Dizdar, Andreas M Raffel, Dieter Hafner, Nikolas H Stoecklein and Wolfram T Knoefel

    Citation: BMC Cancer 2013 13:145

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  31. Content type: Research article

    We attempted to identify novel biomarkers and therapeutic targets for esophageal squamous cell carcinoma by gene expression profiling of frozen esophageal squamous carcinoma specimens and examined the function...

    Authors: Qing Wang, Chenming Ma and Wolfgang Kemmner

    Citation: BMC Cancer 2013 13:137

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  32. Content type: Research article

    αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess w...

    Authors: Chantal van de Schootbrugge, Johan Bussink, Paul N Span, Fred CGJ Sweep, Reidar Grénman, Hanneke Stegeman, Ger JM Pruijn, Johannes HAM Kaanders and Wilbert C Boelens

    Citation: BMC Cancer 2013 13:128

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  33. Content type: Research article

    Increased histone H3 phosphorylation is an essential regulatory mechanism for neoplastic cell transformation. We aimed to explore the role of histone H3 phosphorylation at serine10 (p-H3Ser10) in Epstein-Barr ...

    Authors: Binbin Li, Guoliang Huang, Xiangning Zhang, Rong Li, Jian Wang, Ziming Dong and Zhiwei He

    Citation: BMC Cancer 2013 13:124

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  34. Content type: Research article

    The purpose of this study is to evaluate the prognostic value of TFPI-2 expression in breast cancer patients through examining the correlation between TFPI-2 expression and breast cancer clinicopathologic feat...

    Authors: Cheng Xu, Huijun Wang, Hongyu He, Fengyun Zheng, Yating Chen, Jin Zhang, Xiaoyan Lin, Duan Ma and Hongwei Zhang

    Citation: BMC Cancer 2013 13:118

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  35. Content type: Research article

    Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of the estrogen receptors (ERs) alpha and beta, is a potential proto-oncogene in hormone dependent gynecological malignancies. To bet...

    Authors: Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller and Stephan Polterauer

    Citation: BMC Cancer 2013 13:115

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  36. Content type: Research article

    Aluminum is used in a wide range of applications and is a potential environmental hazard. The known genotoxic effects of aluminum might play a role in the development of breast cancer. However, the data curren...

    Authors: Raquel Mary Rodrigues-Peres, Solange Cadore, Stefanny Febraio, Juliana Karina Heinrich, Katia Piton Serra, Sophie F M Derchain, Jose Vassallo and Luis Otavio Sarian

    Citation: BMC Cancer 2013 13:104

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  37. Content type: Research article

    Recent studies suggest that bacterial endotoxins may be associated with various chronic diseases, including colorectal adenomas and cancer. Given the evidence linking inflammation and colorectal cancer, we sou...

    Authors: Melissa Kang, Patrick Edmundson, Felix Araujo-Perez, Amber N McCoy, Joseph Galanko and Temitope O Keku

    Citation: BMC Cancer 2013 13:91

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  38. Content type: Research article

    The human ERBB2 gene is frequently amplified in breast tumors, and its high expression is associated with poor prognosis. We previously reported a significant inverse correlation between Myc promoter-binding p...

    Authors: Flavia Contino, Claudia Mazzarella, Arianna Ferro, Mariavera Lo Presti, Elena Roz, Carmelo Lupo, Giovanni Perconti, Agata Giallongo and Salvatore Feo

    Citation: BMC Cancer 2013 13:81

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  39. Content type: Research article

    Phosphatase of regenerating liver-3 (PRL-3), a protein tyrosine phosphatase, is highly expressed in multiple human cancers and strongly implicated in tumor progression and cancer metastasis. However, the mecha...

    Authors: Hao Liu, Abdul Qader Omer Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang and Qi Zeng

    Citation: BMC Cancer 2013 13:80

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  40. Content type: Research article

    Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis of various ...

    Authors: Byong Sun Oh, Jeong Won Jang, Jung Hyun Kwon, Chan Ran You, Kyu Won Chung, Chul Seung Kay, Hyun Suk Jung and Seungok Lee

    Citation: BMC Cancer 2013 13:78

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  41. Content type: Research article

    MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal t...

    Authors: Silvia Prislei, Enrica Martinelli, Marisa Mariani, Giuseppina Raspaglio, Steven Sieber, Gabriella Ferrandina, Shohreh Shahabi, Giovanni Scambia and Cristiano Ferlini

    Citation: BMC Cancer 2013 13:72

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  42. Content type: Research article

    Since the definition of different histologic subtypes of urothelial carcinomas by the World Health Organization (WHO) 2004 classification, description of molecular features and clinical behavior of these varia...

    Authors: Bastian Keck, Sven Wach, Robert Stoehr, Frank Kunath, Simone Bertz, Jan Lehmann, Michael Stöckle, Helge Taubert, Bernd Wullich and Arndt Hartmann

    Citation: BMC Cancer 2013 13:71

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  43. Content type: Research article

    TP53 gene mutations can lead to the expression of a dysfunctional protein that in turn may enable genetically unstable cells to survive and change into malignant cells. Mutant p53 accumulates early in cells and ...

    Authors: Manlio Mattioni, Patrizia Chinzari, Silvia Soddu, Lidia Strigari, Vincenzo Cilenti and Eliuccia Mastropasqua

    Citation: BMC Cancer 2013 13:62

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  44. Content type: Research article

    SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as...

    Authors: Cesarina Giallongo, Piera La Cava, Daniele Tibullo, Ignazio Barbagallo, Nunziatina Parrinello, Alessandra Cupri, Fabio Stagno, Carla Consoli, Annalisa Chiarenza, Giuseppe A Palumbo and Francesco Di Raimondo

    Citation: BMC Cancer 2013 13:60

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  45. Content type: Research article

    It has been previously reported that IL-22, one of the cytokines secreted by Th17 cells, demonstrates both a protective and inflammatory promotion effect in inflammatory bowel disease (IBD) through STAT3 signa...

    Authors: Runqiu Jiang, Haiyang Wang, Lei Deng, Jiajie Hou, Ruihua Shi, Ming Yao, Yun Gao, Aihua Yao, Xuehao Wang, Lianzhen Yu and Beicheng Sun

    Citation: BMC Cancer 2013 13:59

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  46. Content type: Research article

    More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in orde...

    Authors: George Pentheroudakis, Vassiliki Kotoula, Wendy De Roock, George Kouvatseas, Pavlos Papakostas, Thomas Makatsoris, Demetris Papamichael, Ioannis Xanthakis, Joseph Sgouros, Despina Televantou, Georgia Kafiri, Athanassios C Tsamandas, Evangelia Razis, Eleni Galani, Dimitrios Bafaloukos, Ioannis Efstratiou…

    Citation: BMC Cancer 2013 13:49

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