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BMC Cancer

Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    The assessment of circulating tumor cells (CTCs) has been shown to enable monitoring of treatment response and early detection of metastatic breast cancer (MBC) recurrence. The aim of this study was to compare...

    Authors: Hanna Huebner, Peter A. Fasching, Walter Gumbrecht, Sebastian Jud, Claudia Rauh, Mark Matzas, Peter Paulicka, Katja Friedrich, Michael P. Lux, Bernhard Volz, Paul Gass, Lothar Häberle, Franziska Meier-Stiegen, Andreas Hartkopf, Hans Neubauer, Katrin Almstedt…

    Citation: BMC Cancer 2018 18:204

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  2. Content type: Research article

    Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma ...

    Authors: Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu and Shusen Zheng

    Citation: BMC Cancer 2018 18:200

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  3. Content type: Research article

    Though peritoneal carcinomatosis reflects a late stage of colorectal cancer (CRC), only few patients present with synchronous or metachronous liver metastases alongside their peritoneal carcinomatosis. It is h...

    Authors: Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V. Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann and Martin Kurt Angele

    Citation: BMC Cancer 2018 18:201

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  4. Content type: Research article

    Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. ...

    Authors: Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard and Boe Sandahl Sorensen

    Citation: BMC Cancer 2018 18:191

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  5. Content type: Research article

    Several efforts have been focused on identification of pathways involved in malignancy, progression, and response to treatment in Glioblastoma (GB). Overexpression of PKCε was detected in histological samples ...

    Authors: Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski and Maria Rybczynska

    Citation: BMC Cancer 2018 18:185

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  6. Content type: Research article

    The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK...

    Authors: Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills and Bryan T. Hennessy

    Citation: BMC Cancer 2018 18:168

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  7. Content type: Research article

    Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synt...

    Authors: Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed and Henrik Antti

    Citation: BMC Cancer 2018 18:167

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  8. Content type: Research article

    Oropharyngeal Squamous Cell Carcinoma (OPSCC) is increasing in incidence despite a decline in traditional risk factors. Human Papilloma Virus (HPV), specifically subtypes 16, 18, 31 and 35, has been implicated...

    Authors: Mitchell G. Rohatensky, Devon M. Livingstone, Paul Mintchev, Heather K. Barnes, Steven C. Nakoneshny, Douglas J. Demetrick, Joseph C. Dort and Guido van Marle

    Citation: BMC Cancer 2018 18:166

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  9. Content type: Research article

    To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propofol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breas...

    Authors: Jeong-Ae Lim, Chung-Sik Oh, Tae-Gyoon Yoon, Ji Yeon Lee, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang and Seong-Hyop Kim

    Citation: BMC Cancer 2018 18:159

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  10. Content type: Research article

    Polycomb repressive complex 2 (PRC2; formed by EZH2, SUZ12, and EED protein subunits) and PRC1 (BMI1 protein) induce gene silencing through histone modification by H3K27me3. In the present study, we characteri...

    Authors: Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung…

    Citation: BMC Cancer 2018 18:158

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  11. Content type: Research article

    Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with...

    Authors: Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky and Kornélia Baghy

    Citation: BMC Cancer 2018 18:157

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  12. Content type: Research article

    Limited data are available regarding the ability of biomarkers to predict complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Complete response translates to bett...

    Authors: J. Martinez-Useros, I. Moreno, M. J. Fernandez-Aceñero, M. Rodriguez-Remirez, A. Borrero-Palacios, A. Cebrian, T. Gomez del Pulgar, L. del Puerto-Nevado, W. Li, A. Puime-Otin, N. Perez, M. S. Soengas and J. Garcia-Foncillas

    Citation: BMC Cancer 2018 18:144

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  13. Content type: Research article

    We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the ro...

    Authors: Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee and Young-Tae Bak

    Citation: BMC Cancer 2018 18:150

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  14. Content type: Research article

    microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circ...

    Authors: Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K. Trapp, Marie Tzschaschel, Sven Mahner, Peter A. Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W. P. Friedl, Wolfgang Janni and Brigitte Rack

    Citation: BMC Cancer 2018 18:141

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  15. Content type: Research article

    Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are neede...

    Authors: Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner…

    Citation: BMC Cancer 2018 18:154

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  16. Content type: Research article

    Programmed death-1 ligand-1 (PD-L1) an important cancer biomarker that can suppress the immune system and its high expression is often reported to be related with increased tumor aggressiveness in some cancers...

    Authors: Koji Harada, Tarannum Ferdous and Yoshiya Ueyama

    Citation: BMC Cancer 2018 18:156

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  17. Content type: Research article

    HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was perform...

    Authors: Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni and Valerio Filippo Profeta

    Citation: BMC Cancer 2018 18:143

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  18. Content type: Research article

    Although EGFR-TKI is the preferred treatment for NSCLC patients with sensitive mutations, subsequent drug resistance is almost inevitable. The specific mechanisms of EGFR-TKI drug resistance can be identified ...

    Authors: Zan-Feng Wang, Sheng-Xiang Ren, Wei Li and Guang-Hui Gao

    Citation: BMC Cancer 2018 18:148

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  19. Content type: Research article

    Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC). Thus, it has been suggested that TIL density or/and i...

    Authors: Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca and Nina Radosevic-Robin

    Citation: BMC Cancer 2018 18:129

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