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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association b...

    Authors: Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević and Tatjana Stanojković

    Citation: BMC Cancer 2019 19:71

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  2. Content type: Research article

    Cancer is a life-threatening disease that causes every fourth death. It is often hard to determine the time point of progression. Therefore, biomarkers for cancer entities that indicate disease progression or ...

    Authors: Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader and Andrea U. Steinbicker

    Citation: BMC Cancer 2019 19:74

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  3. Content type: Research article

    Several previous studies have confirmed that thrombocytosis was related to reduced survival in many solid tumors. However, the prognostic significance of thrombocytosis in endometrial carcinoma (EC) was still ...

    Authors: Dan Nie, E. Yang and Zhengyu Li

    Citation: BMC Cancer 2019 19:73

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  4. Content type: Research article

    Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular sig...

    Authors: Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen and Joseph T. Chang

    Citation: BMC Cancer 2019 19:64

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  5. Content type: Research article

    Poly (ADP-ribose) polymerase inhibitors (PARPi) have become the first targeted therapies available in the treatment of patients with high-grade serous ovarian cancer (HGSOC). We recently described a significan...

    Authors: Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen and Walter H. Gotlieb

    Citation: BMC Cancer 2019 19:44

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  6. Content type: Research article

    Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...

    Authors: Ji-Jin Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen, Wang-Jian Zhang, Wayne R. Lawrence, Fan Zhang, Si-Yang Wang, Ying Sun and Guan-Qun Zhou

    Citation: BMC Cancer 2019 19:37

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  7. Content type: Research article

    Metastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. Previous studies have proved the prog...

    Authors: Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang and Wenhua Li

    Citation: BMC Cancer 2019 19:15

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  8. Content type: Research article

    Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for ...

    Authors: Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro and Rosa Noguera

    Citation: BMC Cancer 2019 19:1

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  9. Content type: Research article

    Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,

    Authors: Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani and Seyed Abdolrahim Rezaee

    Citation: BMC Cancer 2018 18:1287

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  10. Content type: Research article

    Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangement in tissue specimens has been approved by US FDA (Food and Drug Administration) to select treatment for non–small-cell lung ca...

    Authors: Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao and Zhi Hui Zhang

    Citation: BMC Cancer 2018 18:1277

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  11. Content type: Research article

    Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tum...

    Authors: Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke and David Anz

    Citation: BMC Cancer 2018 18:1278

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  12. Content type: Research article

    Definite prognostic clinical factors of benefit for decitabine-based induction chemotherapy in elderly patients newly diagnosed with acute myeloid leukaemia (AML) are not identified. This study was designed to...

    Authors: Jiayu Huang, Huihui Zhao, Ming Hong, Han Zhu, Yu Zhu, Yun Lian, Shan Li, Jianyong Li and Sixuan Qian

    Citation: BMC Cancer 2018 18:1269

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  13. Content type: Technical advance

    Clinical assays for the assessment of the human epidermal growth factor receptor-2 (HER2) status in breast cancer include immunohistochemistry (IHC) and in situ hybridization (ISH), both of which have limitati...

    Authors: David G. Hicks, Brandon Buscaglia, Hideki Goda, Loralee McMahon, Takako Natori, Bradley Turner, Armen Soukiazian, Hisatake Okada and Yasushi Nakano

    Citation: BMC Cancer 2018 18:1266

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  14. Content type: Research article

    Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) will relapse if treatment is withdrawn, but various trials have recently demonstrated that a significant proport...

    Authors: Nuno Cerveira, Bruno Loureiro, Susana Bizarro, Cecília Correia, Lurdes Torres, Susana Lisboa, Joana Vieira, Rui Santos, Dulcineia Pereira, Cláudia Moreira, Sérgio Chacim, Nélson Domingues, Ana Espírito-Santo, Isabel Oliveira, Ilídia Moreira, Luísa Viterbo…

    Citation: BMC Cancer 2018 18:1245

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  15. Content type: Research article

    SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppress...

    Authors: Hyunsung Kim, Yeseul Kim, Yumin Chung, Rehman Abdul, Jongmin Sim, Hyein Ahn, Su-Jin Shin, Seung Sam Paik, Han Joon Kim, Kiseok Jang and Dongho Choi

    Citation: BMC Cancer 2018 18:1244

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  16. Content type: Research article

    The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-...

    Authors: Akihiro Yoshimura, Tadaaki Yamada, Naoko Okura, Takayuki Takeda, Wataru Furutani, Yutaka Kubota, Shinsuke Shiotsu, Osamu Hiranuma, Naoya Nishioka, Yusuke Chihara, Nobuyo Tamiya, Yoshiko Kaneko, Junji Uchino and Koichi Takayama

    Citation: BMC Cancer 2018 18:1241

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  17. Content type: Research article

    EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural e...

    Authors: Jong Sik Lee, Jae Young Hur, In Ae Kim, Hee Joung Kim, Chang Min Choi, Jae Chol Lee, Wan Seop Kim and Kye Young Lee

    Citation: BMC Cancer 2018 18:1236

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  18. Content type: Research article

    Prognostic factors in breast cancer are often measured on a continuous scale, but categorized for clinical decision-making. The primary aim of this study was to evaluate if accounting for continuous non-linear...

    Authors: Carina Forsare, Martin Bak, Anna-Karin Falck, Dorthe Grabau, Fredrika Killander, Per Malmström, Lisa Rydén, Olle Stål, Marie Sundqvist, Pär-Ola Bendahl and Mårten Fernö

    Citation: BMC Cancer 2018 18:1226

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  19. Content type: Research article

    Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Bec...

    Authors: Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru and Dominique Tierny

    Citation: BMC Cancer 2018 18:1219

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  20. Content type: Research article

    A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, ho...

    Authors: Martina Schmitz, Kristin Eichelkraut, Dana Schmidt, Ilona Zeiser, Ziad Hilal, Zena Tettenborn, Alfred Hansel and Hans Ikenberg

    Citation: BMC Cancer 2018 18:1197

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  21. Content type: Research article

    The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid can...

    Authors: Maryam Zarkesh, Azita Zadeh-Vakili, Mahdi Akbarzadeh, S. Ahmad Fanaei, Mehdi Hedayati and Fereidoun Azizi

    Citation: BMC Cancer 2018 18:1199

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  22. Content type: Research article

    Recently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in variou...

    Authors: Donghua Huang, Yizhong Peng, Kaige Ma, Xiangyu Deng, Lu Tang, Doudou Jing and Zengwu Shao

    Citation: BMC Cancer 2018 18:1189

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  23. Content type: Research article

    The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by non-invasive cells, particularly by cells from ductal c...

    Authors: Yasamin Al-Qassab, Silvia Grassilli, Federica Brugnoli, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo

    Citation: BMC Cancer 2018 18:1194

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  24. Content type: Research article

    Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage in the course of disease and therefore carr...

    Authors: Yunhong Tian, Jianlin Wu, Cristian Chagas, Yichao Du, Huan Lyu, Yunhong He, Shouliang Qi, Yong Peng and Jiani Hu

    Citation: BMC Cancer 2018 18:1187

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  25. Content type: Research article

    The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 and CRP, AC score) levels and to evaluate the prognostic value of ...

    Authors: Minjie Mao, Xueping Wang, Hui Sheng, Yijun Liu, Lin Zhang, Shuqin Dai and Pei-dong Chi

    Citation: BMC Cancer 2018 18:1178

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  26. Content type: Research article

    Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this stu...

    Authors: Rui-Lian Chen, Jun Zhao, Xu-Chao Zhang, Na-Na Lou, Hua-Jun Chen, Xue Yang, Jian Su, Zhi Xie, Qing Zhou, Hai-Yan Tu, Wen-Zhao Zhong, Hong-Hong Yan, Wei-Bang Guo, Yi-Long Wu and Jin-Ji Yang

    Citation: BMC Cancer 2018 18:1171

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  27. Content type: Research article

    Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising targets in the therapy of advanced non-small cell lung cancer (NSCLC) and are predominantly detected by immunohistochemistry (IHC)...

    Authors: Claudia Vollbrecht, Dido Lenze, Michael Hummel, Annika Lehmann, Markus Moebs, Nikolaj Frost, Philipp Jurmeister, Leonille Schweizer, Udo Kellner, Manfred Dietel and Maximilian von Laffert

    Citation: BMC Cancer 2018 18:1158

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  28. Content type: Research article

    Drug-drug interactions (DDIs) in subjects enrolling in clinical trials can impact not only safety of the patient but also study drug outcomes and data validity. This makes it critical to adequately screen and ...

    Authors: Lauren A. Marcath, Taylor D. Coe, Emily K. Hoylman, Bruce G. Redman and Daniel L. Hertz

    Citation: BMC Cancer 2018 18:1155

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  29. Content type: Case report

    Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (...

    Authors: Philippe Rochigneux, Jeanne Thomassin-Piana, Sophy Laibe, Serge Brunelle, Naji Salem, Bernard Escudier, Gilles Vassal and Gwenaelle Gravis

    Citation: BMC Cancer 2018 18:1159

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  30. Content type: Research article

    Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in the biology and outcome of a high-risk subset of newly diagnosed multiple myeloma (nMM), this ...

    Authors: Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang and Siegfried Janz

    Citation: BMC Cancer 2018 18:1152

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  31. Content type: Research article

    Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...

    Authors: Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin and Nianyong Chen

    Citation: BMC Cancer 2018 18:1133

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  32. Content type: Research article

    On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer...

    Authors: Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami and Yoshinobu Ohsaki

    Citation: BMC Cancer 2018 18:1136

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  33. Content type: Research article

    Development of chemo−/radioresistance is a major challenge for the current prostate cancer (CaP) therapy. We have previously demonstrated that epithelial cell adhesion molecule (EpCAM) is associated with CaP g...

    Authors: Jie Ni, Paul Cozzi, Julia Beretov, Wei Duan, Joseph Bucci, Peter Graham and Yong Li

    Citation: BMC Cancer 2018 18:1092

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  34. Content type: Research article

    Inter-patient heterogeneity in radiation-induced DNA damage responses is proposed to reflect intrinsic variations in tumour and normal tissue radiation sensitivity, but the prediction of phenotype by a molecul...

    Authors: Kevin Lee Min Chua, Eugenia Li Ling Yeo, Waseem Ahamed Shihabudeen, Sze Huey Tan, Than Than Shwe, Enya Hui Wen Ong, Paula Yeng Po Lam, Khee Chee Soo, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Joseph Tien Seng Wee and Melvin Lee Kiang Chua

    Citation: BMC Cancer 2018 18:1095

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  35. Content type: Research article

    Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypo...

    Authors: Daniel Riani Gotardelo, Lilia Coronato Courrol, Maria Helena Bellini, Flávia Rodrigues de Oliveira Silva and Carlos Roberto Jorge Soares

    Citation: BMC Cancer 2018 18:1090

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  36. Content type: Research article

    Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...

    Authors: Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park

    Citation: BMC Cancer 2018 18:1103

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  37. Content type: Research article

    Invasive micropapillary carcinoma (IMPC) is an unusual and distinct subtype of invasive breast tumor with high propensity for regional lymph node metastases. This study was to identify risk factors accounting ...

    Authors: Fu-Gui Ye, Chen Xia, Ding Ma, Pei-Yang Lin, Xin Hu and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:1085

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  38. Content type: Research article

    Extramammary Paget’s disease (EMPD), a rare skin malignancy with non-specific manifestations, is often misdiagnosed as eczema of scrotum or tinea cruris. Although the diagnosis of EMPD could be confirmed by bi...

    Authors: Hao Guo, Rui-Qun Qi, Jie Sheng, Chang Liu, Hang Ma, He-Xiao Wang, Jiu-Hong Li, Xing-Hua Gao, Yin-Sheng Wan and Hong-Duo Chen

    Citation: BMC Cancer 2018 18:1078

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  39. Content type: Research article

    WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed enviro...

    Authors: Michal Chovanec, Zuzana Cierna, Viera Miskovska, Katarina Machalekova, Katarina Kalavska, Katarina Rejlekova, Daniela Svetlovska, Dusan Macak, Stanislav Spanik, Karol Kajo, Pavel Babal, Michal Mego and Jozef Mardiak

    Citation: BMC Cancer 2018 18:1062

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  40. Content type: Research article

    Small extracellular vesicles (small-EVs) are membranous vesicles that contain unique information regarding the condition of cells and contribute to the recruitment and reprogramming of components associated wi...

    Authors: Chan-Hyeong Lee, Eun-Ju Im, Pyong-Gon Moon and Moon-Chang Baek

    Citation: BMC Cancer 2018 18:1058

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  41. Content type: Research article

    It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify t...

    Authors: Xiaowen Liu, Hong Cai, Weiqi Sheng, Hua Huang, Ziwen Long and Yanong Wang

    Citation: BMC Cancer 2018 18:1048

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  42. Content type: Research article

    P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour sup...

    Authors: Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green and Emad A. Rakha

    Citation: BMC Cancer 2018 18:1027

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  43. Content type: Research article

    Even though the post-operative outcome varies greatly among patients with nodal positive colon cancer (UICC stage III), personalized prediction of systemic disease recurrence is currently insufficient. We inve...

    Authors: Andreas Sperlich, Alexander Balmert, Dietrich Doll, Sabine Bauer, Fabian Franke, Gisela Keller, Dirk Wilhelm, Anna Mur, Michael Respondek, Helmut Friess, Ulrich Nitsche and Klaus-Peter Janssen

    Citation: BMC Cancer 2018 18:998

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  44. Content type: Research article

    The imbalance between the action of the tissue inhibitors of matrix metalloproteinases (TIMPs) and the matrix metalloproteinases (MMPs) is one component of metastasis physiology. TIMP-1 overrides MMP-9 activit...

    Authors: Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Caio Moura, Iran A. Silva, Katia R. Leite, José Pontes-Junior, William C. Nahas, Miguel Srougi and Sabrina T. Reis

    Citation: BMC Cancer 2018 18:992

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  45. Content type: Research article

    The prognostic biomarker for patients undergoing curative liver metastasectomy for colorectal cancer (CRC) is lacking. The purpose was to investigate the prognostic role of a lack of CDX2 expression, which has...

    Authors: Yasuyuki Shigematsu, Kentaro Inamura, Noriko Yamamoto, Yoshihiro Mise, Akio Saiura, Yuichi Ishikawa, Shunji Takahashi and Hiroaki Kanda

    Citation: BMC Cancer 2018 18:980

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  46. Content type: Study protocol

    The prognosis for pancreatic cancer remains poor despite diagnostic advances and treatments with new chemotherapeutic regimens. The five year survival rate remains below 3%. Consequently, there is an urgent ne...

    Authors: Cindy Canivet, Sophie Gourgou-Bourgade, Bertrand Napoléon, Laurent Palazzo, Nicolas Flori, Pierre Guibert, Guillaume Piessen, Dominique Farges-Bancel, Jean-François Seitz, Eric Assenat, Véronique Vendrely, Stéphanie Truant, Geoffroy Vanbiervliet, Philippe Berthelémy, Stéphane Garcia, Anne Gomez-Brouchet…

    Citation: BMC Cancer 2018 18:986

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  47. Content type: Research article

    We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normaliz...

    Authors: Yukio Suzuki, Aya Tokinaga-Uchiyama, Taichi Mizushima, Yasuyo Maruyama, Tae Mogami, Nahoko Shikata, Atsuko Ikeda, Hiroshi Yamamoto and Etsuko Miyagi

    Citation: BMC Cancer 2018 18:973

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