Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Research article

    A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

    Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in mur...

    Wayne J. Aston, Danika E. Hope, Anna K. Nowak, Bruce W. Robinson, Richard A. Lake and W. Joost Lesterhuis

    BMC Cancer 2017 17:684

    Published on: 16 October 2017

  2. Study protocol

    Benefits of home-based multidisciplinary exercise and supportive care in inoperable non-small cell lung cancer – protocol for a phase II randomised controlled trial

    Lung cancer is one of the most commonly diagnosed cancers, and is a leading cause of cancer mortality world-wide. Due to lack of early specific symptoms, the majority of patients present with advanced, inopera...

    Lara Edbrooke, Sanchia Aranda, Catherine L. Granger, Christine F. McDonald, Mei Krishnasamy, Linda Mileshkin, Louis Irving, Sabine Braat, Ross A. Clark, Ian Gordon and Linda Denehy

    BMC Cancer 2017 17:663

    Published on: 29 September 2017

  3. Research article

    Assessment of Ki67 and uPA/PAI-1 expression in intermediate-risk early stage breast cancers

    The objective of this study was to compare the efficacy of biomarkers in assessing the risk of breast cancer recurrence in patients with node-negative or micrometastatic grade II breast cancer. Specifically, w...

    Elise Deluche, Laurence Venat-Bouvet, Sophie Leobon, Veronique Fermeaux, Joelle Mollard, Nadira Saidi, Isabelle Jammet, Yves Aubard and Nicole Tubiana-Mathieu

    BMC Cancer 2017 17:662

    Published on: 27 September 2017

  4. Research article

    MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer

    Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulatin...

    Sunyoung Park, Kiyoon Eom, Jungho Kim, Hyeeun Bang, Hye-young Wang, Sungwoo Ahn, Geehyuk Kim, Hyoungsoon Jang, Sunghyun Kim, Dongsup Lee, Kwang Hwa Park and Hyeyoung Lee

    BMC Cancer 2017 17:658

    Published on: 21 September 2017

  5. Research article

    Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer

    There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised met...

    Fiona R. James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D. Brenton, Paul D. P. Pharoah and H. Raza Ali

    BMC Cancer 2017 17:657

    Published on: 20 September 2017

  6. Research article

    The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane model

    Non-small cell lung cancer (NSCLC) has led to the highest cancer-related mortality for decades. To enhance the efficiency of early diagnosis and therapy, more efforts are urgently needed to reveal the origins ...

    Rong-quan He, Xiao-jiao Li, Lu Liang, You Xie, Dian-zhong Luo, Jie Ma, Zhi-gang Peng, Xiao-hua Hu and Gang Chen

    BMC Cancer 2017 17:655

    Published on: 19 September 2017

  7. Research article

    XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis

    Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis, the survival rate of this disease has still not i...

    Azhar R. Hussain, Abdul Khalid Siraj, Maqbool Ahmed, Rong Bu, Poyil Pratheeshkumar, Alanood M. Alrashed, Zeeshan Qadri, Dahish Ajarim, Fouad Al-Dayel, Shaham Beg and Khawla S. Al-Kuraya

    BMC Cancer 2017 17:640

    Published on: 11 September 2017

  8. Research article

    Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

    Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We asses...

    Charles-André Philip, Ido Laskov, Marie-Claude Beauchamp, Maud Marques, Oreekha Amin, Joanna Bitharas, Roy Kessous, Liron Kogan, Tahira Baloch, Walter H. Gotlieb and Amber Yasmeen

    BMC Cancer 2017 17:638

    Published on: 8 September 2017

  9. Research article

    IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

    The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors...

    Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi and Isabelle Bernard-Pierrot

    BMC Cancer 2017 17:636

    Published on: 7 September 2017

  10. Research article

    Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer

    Prostate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important ...

    Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M. McKee, Clare Verrill, Richard J. Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans and Ruth J. Muschel

    BMC Cancer 2017 17:634

    Published on: 6 September 2017

  11. Research article

    Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

    Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical s...

    Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima and Masatoshi Tagawa

    BMC Cancer 2017 17:622

    Published on: 5 September 2017

  12. Research article

    Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding

    MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptos...

    Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis and Eduardas Aleknavicius

    BMC Cancer 2017 17:607

    Published on: 1 September 2017

  13. Research article

    Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma

    Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this stu...

    Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara and Yasuhiro Kodera

    BMC Cancer 2017 17:610

    Published on: 1 September 2017

  14. Research article

    Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer

    The recently developed reagent, eribulin mesylate (eribulin), is a microtubule dynamics inhibitor with a mechanism of action that differs from those of taxanes and vinca alkaloids. This drug is considered to b...

    Shinichiro Kashiwagi, Wakaba Fukushima, Yuka Asano, Wataru Goto, Koji Takada, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    BMC Cancer 2017 17:604

    Published on: 31 August 2017

  15. Research article

    NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity

    N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is involved in the development of human cancers. Prev...

    Qijiong Li, Xiaofeng Liu, Kemin Jin, Min Lu, Chunfeng Zhang, Xiaojuan Du and Baocai Xing

    BMC Cancer 2017 17:605

    Published on: 31 August 2017

  16. Research article

    Is neuron-specific enolase useful for diagnosing malignant pleural effusions? evidence from a validation study and meta-analysis

    Neuron-Specific enolase (NSE) has been used as a typical tumor marker and shows a potential to diagnose malignant pleural effusion (MPE). The ability of NSE in diagnosing MPE has been investigated in many stud...

    Jing Zhu, Mei Feng, Liqun Liang, Ni Zeng, Chun Wan, Ting Yang, Yongchun Shen and Fuqiang Wen

    BMC Cancer 2017 17:590

    Published on: 30 August 2017

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