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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Content type: Research article

    An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL i...

    Authors: Valesca P. Retèl, Lotte M. G. Steuten, Marnix H. Geukes Foppen, Janne C. Mewes, Melanie A. Lindenberg, John B. A. G. Haanen and Wim H. van Harten

    Citation: BMC Cancer 2018 18:895

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  2. Content type: Research article

    Pseudogenes are RNA transcripts with high homology with its parent protein-coding genes. Although pseudogenes lost the ability to produce protein, it still exert import biological function, and play important ...

    Authors: Fengqiong Liu, Ruijie Gong, Baochang He, Fa Chen and Zhijian Hu

    Citation: BMC Cancer 2018 18:894

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  3. Content type: Study protocol

    Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced immune response suppression. However, the current syste...

    Authors: J. Rotman, C. H. Mom, E. S. Jordanova, T. D. de Gruijl and G. G. Kenter

    Citation: BMC Cancer 2018 18:888

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  4. Content type: Research article

    In breast cancer (BC), deregulation of DNA methylation leads to aberrant expressions and functions of key regulatory genes. In our study, we investigated the relationship between the methylation profiles of ge...

    Authors: Lenka Kalinkova, Iveta Zmetakova, Bozena Smolkova, Gabriel Minarik, Tatiana Sedlackova, Viera Horvathova Kajabova, Zuzana Cierna, Michal Mego and Ivana Fridrichova

    Citation: BMC Cancer 2018 18:875

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  5. Content type: Research article

    The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the gr...

    Authors: Vilde Elisabeth Mikkelsen, Anne Line Stensjøen, Unn Sophie Granli, Erik Magnus Berntsen, Øyvind Salvesen, Ole Solheim and Sverre Helge Torp

    Citation: BMC Cancer 2018 18:862

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  6. Content type: Research article

    The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.

    Authors: Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu and Zhengyu Jin

    Citation: BMC Cancer 2018 18:833

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  7. Content type: Research article

    Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and indu...

    Authors: Usama Khamis Hussein, Ho Sung Park, Jun Sang Bae, Kyoung Min Kim, Yun Jo Chong, Chan Young Kim, Keun Sang Kwon, Myoung Ja Chung, Ho Lee, Myoung Jae Kang, Woo Sung Moon and Kyu Yun Jang

    Citation: BMC Cancer 2018 18:836

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  8. Content type: Research article

    Nucleophosmin is a non-ribosomal nucleolar phosphoprotein that is found primarily in the nucleolus region of cell nucleus, plays multiple important roles in tumor processes. Accumulated previous studies have r...

    Authors: Siying Chen, Hairong He, Yan Wang, Leichao Liu, Yang Liu, Haisheng You, Yalin Dong and Jun Lyu

    Citation: BMC Cancer 2018 18:838

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  9. Content type: Research article

    Neck dissection is standard in surgical management of oral squamous cell carcinomas (oscc). However, the immunologic link between primary tumor and lymph nodes is insufficiently understood. Galectin 3 (Gal3) p...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam, Marco Kesting and Manuel Weber

    Citation: BMC Cancer 2018 18:823

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  10. Content type: Research article

    Practical and reliable genotyping procedures with a considerable number of samples are required not only for risk-adapted therapeutic strategies, but also for stratifying patients into future clinical trials f...

    Authors: Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa and Yasuhiro Koh

    Citation: BMC Cancer 2018 18:826

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  11. Content type: Research article

    Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced pheno...

    Authors: Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang and Yongbaek Kim

    Citation: BMC Cancer 2018 18:819

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  12. Content type: Research article

    The function of hornerin (HRNR), a member of the S100 protein family, is poorly clarified in the development of human tumors. The role of HRNR in hepatocellular carcinoma (HCC) progression is investigated in t...

    Authors: Shun-Jun Fu, Shun-Li Shen, Shao-Qiang Li, Yun-Peng Hua, Wen-Jie Hu, BeiChu Guo and Bao-Gang Peng

    Citation: BMC Cancer 2018 18:815

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  13. Content type: Research article

    Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification...

    Authors: Bray Denard, Sharon Jiang, Yan Peng and Jin Ye

    Citation: BMC Cancer 2018 18:813

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  14. Content type: Research article

    Molecular analysis of circulating tumour DNA (ctDNA) is becoming increasingly important in clinical treatment decisions. A pilot External Quality Assessment (EQA) scheme for ctDNA analysis was organized by fou...

    Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Simon J. Patton, Nicola Normanno, Francesca Fenizia, Rachel Butler, Melanie Cheetham, Jennifer A. Fairley, Hannah Williams, Jacqueline A. Hall, Ed Schuuring and Zandra C. Deans

    Citation: BMC Cancer 2018 18:804

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  15. Content type: Research article

    Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in the adipose tissue. HSL has been implicated to pla...

    Authors: Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt and Guido Eibl

    Citation: BMC Cancer 2018 18:797

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  16. Content type: Research article

    Hepatocellular carcinoma (HCC) is among the deadliest cancers due to its heterogeneity, contributing to chemoresistance and recurrence. Cancer stem-like cells (CSCs) are suggested to play an important role in ...

    Authors: Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li and Robert C. G. Martin

    Citation: BMC Cancer 2018 18:783

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  17. Content type: Research article

    The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adeno...

    Authors: Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff and Anna Trauzold

    Citation: BMC Cancer 2018 18:777

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  18. Content type: Research article

    Programmed death ligand 1/2 (PD-L1/PD-L2) expression has been established as a prognostic factor for various solid tumors and as a predictive factor for PD-1 blockade therapy, but scant data on its role in gal...

    Authors: Jianzhen Lin, Junyu Long, Xueshuai Wan, Jingci Chen, Yi Bai, Anqiang Wang, Xiaobo Yang, Yan Wu, Simon C. Robson, Xinting Sang and Haitao Zhao

    Citation: BMC Cancer 2018 18:766

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  19. Content type: Research article

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with high metastatic potential. Clinical observations suggest that there is disease heterogeneity among patients with different sit...

    Authors: Ibrahim H. Sahin, Harold Elias, Joanne F. Chou, Marinela Capanu and Eileen M. O’Reilly

    Citation: BMC Cancer 2018 18:769

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  20. Content type: Research article

    Controversy exists for the use of Ki67 protein expression as a predictive marker to select patients who do or do not derive benefit from adjuvant endocrine therapy. Whether other proliferation markers, like Cy...

    Authors: Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest and Sabine Linn

    Citation: BMC Cancer 2018 18:761

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  21. Content type: Research article

    Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In ...

    Authors: M. B. Mogensen, M. Rossing, O. Østrup, P. N. Larsen, P. J. Heiberg Engel, L. N. Jørgensen, E. V. Hogdall, J. Eriksen, P. Ibsen, P. Jess, M. Grauslund, H. J. Nielsen, F. C. Nielsen, B. Vainer and K. Osterlind

    Citation: BMC Cancer 2018 18:752

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  22. Content type: Research article

    The receptor CXCR4 and its ligand CXCL12 play crucial roles in breast cancer. Despite the fact that the spontaneous feline mammary carcinoma (FMC) is considered a suitable model for breast cancer studies, the ...

    Authors: Cláudia S. Marques, Ana Rita Santos, Andreia Gameiro, Jorge Correia and Fernando Ferreira

    Citation: BMC Cancer 2018 18:741

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  23. Content type: Research article

    Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...

    Authors: Ji-Jin Yao, Ya-Nan Jin, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou, Wang-Jian Zhang, Zhi-Bin, Cheng, Jun Ma, Zhen-Yu Qi and Ying Sun

    Citation: BMC Cancer 2018 18:740

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  24. Content type: Research article

    The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke ...

    Authors: Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Kristin A. Taskén, Gunhild M. Mælandsmo, Arne Yndestad, Bente Halvorsen, Odd Terje Brustugun, Pål Aukrust, Thor Ueland and Åslaug Helland

    Citation: BMC Cancer 2018 18:739

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  25. Content type: Research article

    MLKL is the most important executor of necroptosis pathway. Recent studies have demonstrated that MLKL could serve as a potential prognostic biomarker for cancer patients. However, most studies reported so far...

    Authors: Binwu Hu, Deyao Shi, Xiao Lv, Songfeng Chen, Qin Huang, Mao Xie and Zengwu Shao

    Citation: BMC Cancer 2018 18:736

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  26. Content type: Research article

    Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...

    Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies

    Citation: BMC Cancer 2018 18:724

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  27. Content type: Research article

    Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treat...

    Authors: Liping Han, Qiufang Jiang, Wei Yao, Tian Fu and Qingdi Zeng

    Citation: BMC Cancer 2018 18:725

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  28. Content type: Research article

    Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels.

    Authors: Martin Zacharias, Luka Brcic, Sylvia Eidenhammer and Helmut Popper

    Citation: BMC Cancer 2018 18:717

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  29. Content type: Research article

    The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has...

    Authors: Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino and Isabella Castellano

    Citation: BMC Cancer 2018 18:703

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  30. Content type: Research article

    Invasive cervical cancer (ICC) is caused by high-risk human papillomavirus types (HR-HPVs) and is usually preceded by a long phase of intraepithelial neoplasia (CIN). Before invasion, (epi) genetic changes, po...

    Authors: Barbara Pardini, Daniela De Maria, Antonio Francavilla, Cornelia Di Gaetano, Guglielmo Ronco and Alessio Naccarati

    Citation: BMC Cancer 2018 18:696

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  31. Content type: Research article

    MicroRNAs can be used in the prognosis of malignancies; however, their regulatory mechanisms are unknown, especially in pancreatic ductal adenocarcinoma (PDAC).

    Authors: Ce Li, Qian Dong, Xiaofang Che, Ling Xu, Zhi Li, Yibo Fan, Kezuo Hou, Shuo Wang, Jinglei Qu, Lu Xu, Ti Wen, Xianghong Yang, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2018 18:681

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  32. Content type: Research article

    Oral cancer is a serious problem owing to its poor prognosis and destruction of patients’ eating ability as well as facial appearance. Epidemiological studies can provide aetiological clues for prevention. The...

    Authors: Jin-Ye Fu, Chun-Xiao Wu, Chen-Ping Zhang, Jing Gao, Jian-Feng Luo, Shu-Kun Shen, Ying Zheng and Zhi-Yuan Zhang

    Citation: BMC Cancer 2018 18:686

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  33. Content type: Research article

    Almost all of the extracellular matrix (ECM) components can be degraded by the endoproteinases matrix metalloproteinases (MMPs). Important regulators of MMPs, and thereby of the extracellular environment, are ...

    Authors: Camilla Böckelman, Ines Beilmann-Lehtonen, Tuomas Kaprio, Selja Koskensalo, Taina Tervahartiala, Harri Mustonen, Ulf-Håkan Stenman, Timo Sorsa and Caj Haglund

    Citation: BMC Cancer 2018 18:679

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  34. Content type: Research article

    Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating...

    Authors: Gaoping Zhao, Tao Jiang, Yanzhuo Liu, Guoli Huai, Chunbin Lan, Guiquan Li, Guiqing Jia, Kang Wang and Maozhu Yang

    Citation: BMC Cancer 2018 18:676

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  35. Content type: Research article

    RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibilit...

    Authors: Huiying Xu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin and Yuntao Xie

    Citation: BMC Cancer 2018 18:662

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  36. Content type: Research article

    A previous report showed that a glucagon-like peptide-1 receptor (GLP-1R) agonist (exenatide) induced apoptosis in endometrial cancer cells. However, the pathophysiological role of GLP-1R in endometrial cancer...

    Authors: Ranka Kanda, Haruko Hiraike, Osamu Wada-Hiraike, Takayuki Ichinose, Kazunori Nagasaka, Yuko Sasajima, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga and Takuya Ayabe

    Citation: BMC Cancer 2018 18:657

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  37. Content type: Research article

    Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. In pediatric malignancies, in particu...

    Authors: Giulia Bertolini, Luca Bergamaschi, Andrea Ferrari, Salvatore L. Renne, Paola Collini, Cecilia Gardelli, Marta Barisella, Giovanni Centonze, Stefano Chiaravalli, Cinzia Paolino, Massimo Milione, Maura Massimino, Michela Casanova and Patrizia Gasparini

    Citation: BMC Cancer 2018 18:652

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  38. Content type: Research article

    Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechan...

    Authors: Xue Hou, Run Gong, Jianhua Zhan, Ting Zhou, Yuxiang Ma, Yuanyuan Zhao, Yaxiong Zhang, Gang Chen, Zhonghan Zhang, Shuxiang Ma, Xi Chen, Fangfang Gao, Shaodong Hong, Fan Luo, Wenfeng Fang, Yunpeng Yang…

    Citation: BMC Cancer 2018 18:641

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  39. Content type: Case report

    Primary malignant melanoma of the vagina is extremely rare, with a poorer prognosis than cutaneous malignant melanoma. Previous studies have explored the repurposing of itraconazole, a common oral anti-fungal ...

    Authors: Kayo Inoue, Hiroshi Tsubamoto, Roze Isono-Nakata, Kazuko Sakata and Nami Nakagomi

    Citation: BMC Cancer 2018 18:630

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  40. Content type: Research article

    This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC). The prognostic significance of...

    Authors: Kenneth Lai, Slade Matthews, James S. Wilmott, Murray C. Killingsworth, Jim L. Yong, Nicole J. Caixeiro, James Wykes, Allan Samakeh, Dion Forstner, Mark Lee, John McGuinness, Navin Niles, Angela Hong, Ardalan Ebrahimi and Cheok Soon Lee

    Citation: BMC Cancer 2018 18:624

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  41. Content type: Research article

    Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.

    Authors: Marie-Christine Heinrich, Cosima Göbel, Martina Kluth, Christian Bernreuther, Charlotte Sauer, Cornelia Schroeder, Christina Möller-Koop, Claudia Hube-Magg, Patrick Lebok, Eike Burandt, Guido Sauter, Ronald Simon, Hartwig Huland, Markus Graefen, Hans Heinzer, Thorsten Schlomm…

    Citation: BMC Cancer 2018 18:612

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  42. Content type: Research article

    Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone ...

    Authors: Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi and Tae Hoon Kim

    Citation: BMC Cancer 2018 18:605

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  43. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-...

    Authors: Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino…

    Citation: BMC Cancer 2018 18:597

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  44. Content type: Research article

    Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis e...

    Authors: Juan Fernando Sánchez Vega, Magdali del Rocío Murillo Bacilio, Adrián Santiago Vintimilla Condoy, Araceli Miroslava Palta González, José Alfredo Crespo Astudillo and Franklin Geovany Mora-Bravo

    Citation: BMC Cancer 2018 18:587

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  45. Content type: Research article

    CDCP1, a transmembrane protein with tumor pro-metastatic activity, was recently identified as a prognostic marker in TNBC, the most aggressive breast cancer subtype still lacking an effective molecular targete...

    Authors: Luca Forte, Federica Turdo, Cristina Ghirelli, Piera Aiello, Patrizia Casalini, Marilena Valeria Iorio, Elvira D’Ippolito, Patrizia Gasparini, Roberto Agresti, Beatrice Belmonte, Gabriella Sozzi, Lucia Sfondrini, Elda Tagliabue, Manuela Campiglio and Francesca Bianchi

    Citation: BMC Cancer 2018 18:586

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  46. Content type: Research article

    Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis i...

    Authors: Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone and Koyamangalath Krishnan

    Citation: BMC Cancer 2018 18:564

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