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Systems biology, post-genomic analysis and emerging technologies

This section will consider studies on all aspects of the function of biological systems at the molecular and cellular level, in particular those addressing network modeling, quantitative analyses and the integration of different levels of information. Topics of interest include, but are not limited to, deep sequencing-based technologies, computational biology and machine learning in relation to cancer biology.

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  1. Content type: Technical advance

    Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small ...

    Authors: Juan Martínez-Aguilar, Roderick Clifton-Bligh and Mark P Molloy

    Citation: BMC Cancer 2015 15:199

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  2. Content type: Research article

    Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct m...

    Authors: Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard and Finn C Nielsen

    Citation: BMC Cancer 2015 15:151

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  3. Content type: Research article

    Colorectal cancer is one of the major causes of cancer mortality world-wide. Prevention would improve if at-risk subjects could be identified. The aim of this study was to characterise plasma protein biomarker...

    Authors: Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi and Domenico Palli

    Citation: BMC Cancer 2015 15:56

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  4. Content type: Research article

    The evolution of mutations in the BCR-ABL1 fusion gene transcript renders CML patients resistant to tyrosine kinase inhibitor (TKI) based therapy. Thus screening for BCR-ABL1 mutations is recommended particularly...

    Authors: Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg and Monica Hermanson

    Citation: BMC Cancer 2015 15:45

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  5. Content type: Software

    We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several areas for improvement. In this paper we present s...

    Authors: Chirayu Pankaj Goswami and Harikrishna Nakshatri

    Citation: BMC Cancer 2014 14:970

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  6. Content type: Research article

    Strongly increased uptake of glucose is a hallmark of solid malignant tumors. This phenotype can be triggered by hypoxia-induced gene expression changes or can occur independently of hypoxia as a consequence o...

    Authors: Arnulf Mayer, Marcus Schmidt, Alexander Seeger, André Franke Serras, Peter Vaupel and Heinz Schmidberger

    Citation: BMC Cancer 2014 14:760

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  7. Content type: Research article

    Dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. Our study aims to characterize global differences between transcriptional regulatory program...

    Authors: David Cordero, Xavier Solé, Marta Crous-Bou, Rebeca Sanz-Pamplona, Laia Paré-Brunet, Elisabet Guinó, David Olivares, Antonio Berenguer, Cristina Santos, Ramón Salazar, Sebastiano Biondo and Víctor Moreno

    Citation: BMC Cancer 2014 14:708

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  8. Content type: Research article

    Increasing focus on potentially unnecessary diagnosis and treatment of certain breast cancers prompted our investigation of whether clinical and mammographic features predictive of invasive breast cancer versu...

    Authors: Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske and Elizabeth S Burnside

    Citation: BMC Cancer 2014 14:584

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  9. Content type: Research article

    Tyrosine phosphorylation (pTyr) is an important cancer relevant posttranslational modification since it regulates protein activity and cellular localization. By controlling cell growth and differentiation it p...

    Authors: Lioudmila Elfineh, Christina Classon, Anna Asplund, Ulf Pettersson, Masood Kamali-Moghaddam and Sara Bergström Lind

    Citation: BMC Cancer 2014 14:435

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  10. Content type: Research article

    This study aimed at the identification of prognostic gene expression markers in early primary colorectal carcinomas without metastasis at the time point of surgery by analyzing genome-wide gene expression prof...

    Authors: Marion Fehlker, Matthew R Huska, Thomas Jöns, Miguel A Andrade-Navarro and Wolfgang Kemmner

    Citation: BMC Cancer 2014 14:64

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  11. Content type: Research article

    Membrane vesicles released by neoplastic cells into extracellular medium contain potential of carrying arrays of oncogenic molecules including proteins and microRNAs (miRNA). Extracellular (exosome-like) vesic...

    Authors: Stefan Kruger, Zakaria Y Abd Elmageed, David H Hawke, Philipp M Wörner, David A Jansen, Asim B Abdel-Mageed, Eckhard U Alt and Reza Izadpanah

    Citation: BMC Cancer 2014 14:44

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  12. Content type: Research article

    Resistance to platinum-based chemotherapy remains a major impediment in the treatment of serous epithelial ovarian cancer. The objective of this study was to use gene expression profiling to delineate major de...

    Authors: Madhuri Koti, Robert J Gooding, Paulo Nuin, Alexandria Haslehurst, Colleen Crane, Johanne Weberpals, Timothy Childs, Peter Bryson, Moyez Dharsee, Kenneth Evans, Harriet E Feilotter, Paul C Park and Jeremy A Squire

    Citation: BMC Cancer 2013 13:549

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  13. Content type: Research article

    Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of the disease which convey unpredictable, and poor prognosis du...

    Authors: Nandini Dey, Benjamin G Barwick, Carlos S Moreno, Maja Ordanic-Kodani, Zhengjia Chen, Gabriella Oprea-Ilies, Weining Tang, Charles Catzavelos, Kimberly F Kerstann, George W Sledge Jr., Mark Abramovitz, Mark Bouzyk, Pradip De and Brian R Leyland-Jones

    Citation: BMC Cancer 2013 13:537

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  14. Content type: Research article

    Gastric cancer (GC) is a threat to human health with increasing incidence and mortality worldwide. Down-regulation or absence of RAF kinase inhibitor protein (RKIP) was associated with the occurrence, differen...

    Authors: Huan Gu, Xianquan Zhan, Guiying Zhang, Lu Yan, William CS Cho, Maoyu Li, Ting Liu and Zhuchu Chen

    Citation: BMC Cancer 2013 13:536

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  15. Content type: Research article

    The circadian clock and cell cycle are two global regulatory systems that have pervasive behavioral and physiological effects on eukaryotic cells, and both play a role in cancer development. Recent studies hav...

    Authors: Yingying Mao, Alan Fu, Derek Leaderer, Tongzhang Zheng, Kun Chen and Yong Zhu

    Citation: BMC Cancer 2013 13:498

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