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BMC Cancer

Systems biology, post-genomic analysis and emerging technologies

This section will consider studies on all aspects of the function of biological systems at the molecular and cellular level, in particular those addressing network modeling, quantitative analyses and the integration of different levels of information. Topics of interest include, but are not limited to, deep sequencing-based technologies, computational biology and machine learning in relation to cancer biology.

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  1. Content type: Technical advance

    Circulating tumor cells (CTCs) are malignant cells that have migrated from solid cancers into the blood, where they are typically present in rare numbers. There is great interest in using CTCs to monitor respo...

    Authors: Daniel E Campton, Arturo B Ramirez, Joshua J Nordberg, Nick Drovetto, Alisa C Clein, Paulina Varshavskaya, Barry H Friemel, Steve Quarre, Amy Breman, Michael Dorschner, Sibel Blau, C Anthony Blau, Daniel E Sabath, Jackie L Stilwell and Eric P Kaldjian

    Citation: BMC Cancer 2015 15:360

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  2. Content type: Research Article

    Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory networ...

    Authors: Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen and Sampsa Hautaniemi

    Citation: BMC Cancer 2015 15:319

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  3. Content type: Research article

    Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and a significant public health problem in East Asia, where it is associated with infection by the parasite Opisthorchis viverr...

    Authors: Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony and Jason Mulvenna

    Citation: BMC Cancer 2015 15:309

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  4. Content type: Technical advance

    Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small ...

    Authors: Juan Martínez-Aguilar, Roderick Clifton-Bligh and Mark P Molloy

    Citation: BMC Cancer 2015 15:199

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  5. Content type: Research article

    Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct m...

    Authors: Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard and Finn C Nielsen

    Citation: BMC Cancer 2015 15:151

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  6. Content type: Research article

    Colorectal cancer is one of the major causes of cancer mortality world-wide. Prevention would improve if at-risk subjects could be identified. The aim of this study was to characterise plasma protein biomarker...

    Authors: Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi and Domenico Palli

    Citation: BMC Cancer 2015 15:56

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  7. Content type: Research article

    The evolution of mutations in the BCR-ABL1 fusion gene transcript renders CML patients resistant to tyrosine kinase inhibitor (TKI) based therapy. Thus screening for BCR-ABL1 mutations is recommended particularly...

    Authors: Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg and Monica Hermanson

    Citation: BMC Cancer 2015 15:45

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  8. Content type: Software

    We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several areas for improvement. In this paper we present s...

    Authors: Chirayu Pankaj Goswami and Harikrishna Nakshatri

    Citation: BMC Cancer 2014 14:970

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  9. Content type: Research article

    Strongly increased uptake of glucose is a hallmark of solid malignant tumors. This phenotype can be triggered by hypoxia-induced gene expression changes or can occur independently of hypoxia as a consequence o...

    Authors: Arnulf Mayer, Marcus Schmidt, Alexander Seeger, André Franke Serras, Peter Vaupel and Heinz Schmidberger

    Citation: BMC Cancer 2014 14:760

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  10. Content type: Research article

    Dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. Our study aims to characterize global differences between transcriptional regulatory program...

    Authors: David Cordero, Xavier Solé, Marta Crous-Bou, Rebeca Sanz-Pamplona, Laia Paré-Brunet, Elisabet Guinó, David Olivares, Antonio Berenguer, Cristina Santos, Ramón Salazar, Sebastiano Biondo and Víctor Moreno

    Citation: BMC Cancer 2014 14:708

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  11. Content type: Research article

    Increasing focus on potentially unnecessary diagnosis and treatment of certain breast cancers prompted our investigation of whether clinical and mammographic features predictive of invasive breast cancer versu...

    Authors: Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske and Elizabeth S Burnside

    Citation: BMC Cancer 2014 14:584

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  12. Content type: Research article

    Tyrosine phosphorylation (pTyr) is an important cancer relevant posttranslational modification since it regulates protein activity and cellular localization. By controlling cell growth and differentiation it p...

    Authors: Lioudmila Elfineh, Christina Classon, Anna Asplund, Ulf Pettersson, Masood Kamali-Moghaddam and Sara Bergström Lind

    Citation: BMC Cancer 2014 14:435

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  13. Content type: Research article

    This study aimed at the identification of prognostic gene expression markers in early primary colorectal carcinomas without metastasis at the time point of surgery by analyzing genome-wide gene expression prof...

    Authors: Marion Fehlker, Matthew R Huska, Thomas Jöns, Miguel A Andrade-Navarro and Wolfgang Kemmner

    Citation: BMC Cancer 2014 14:64

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  14. Content type: Research article

    Membrane vesicles released by neoplastic cells into extracellular medium contain potential of carrying arrays of oncogenic molecules including proteins and microRNAs (miRNA). Extracellular (exosome-like) vesic...

    Authors: Stefan Kruger, Zakaria Y Abd Elmageed, David H Hawke, Philipp M Wörner, David A Jansen, Asim B Abdel-Mageed, Eckhard U Alt and Reza Izadpanah

    Citation: BMC Cancer 2014 14:44

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