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BMC Cancer

Systems biology, post-genomic analysis and emerging technologies

This section will consider studies on all aspects of the function of biological systems at the molecular and cellular level, in particular those addressing network modeling, quantitative analyses and the integration of different levels of information. Topics of interest include, but are not limited to, deep sequencing-based technologies, computational biology and machine learning in relation to cancer biology.

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  1. Content type: Research article

    Next Generation Sequencing (NGS) has become a valuable tool for molecular landscape characterization of cancer genomes, leading to a better understanding of tumor onset and progression, and opening new avenues...

    Authors: Silvia Bonfiglio, Irene Vanni, Valeria Rossella, Anna Truini, Dejan Lazarevic, Maria Giovanna Dal Bello, Angela Alama, Marco Mora, Erika Rijavec, Carlo Genova, Davide Cittaro, Francesco Grossi and Simona Coco

    Citation: BMC Cancer 2016 16:692

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  2. Content type: Research article

    The progression of colorectal cancer (CRC) involves recurrent amplifications/mutations in the epidermal growth factor receptor (EGFR) and downstream signal transducers of the Ras pathway, KRAS and BRAF. Whethe...

    Authors: Narendra Padhan, Torbjörn E. M. Nordling, Magnus Sundström, Peter Åkerud, Helgi Birgisson, Peter Nygren, Sven Nelander and Lena Claesson-Welsh

    Citation: BMC Cancer 2016 16:683

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  3. Content type: Research article

    Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and appears to be a link between the apoptotic response triggered by cancer and the anti-tumoral activity of the immune system. Our understanding ...

    Authors: Juan Carlos Higareda-Almaraz, Juan S. Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A. Valtierra-Gutierrez, Christiane Dinsart, Gabriel A. Rabinovich, Jiri Stulik, Frank Rösl and Bladimiro Rincon-Orozco

    Citation: BMC Cancer 2016 16:680

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  4. Content type: Research article

    Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely u...

    Authors: Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder and Hugo J. W. L. Aerts

    Citation: BMC Cancer 2016 16:611

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  5. Content type: Research article

    Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset...

    Authors: Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell and Anita Bane

    Citation: BMC Cancer 2016 16:555

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  6. Content type: Research article

    The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive...

    Authors: Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John-Patrick Mpindi, Samuli Eldfors, Oscar Brück, Tero Aittokallio and Olli Kallioniemi

    Citation: BMC Cancer 2016 16:378

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  7. Content type: Research article

    Gastric cancer is the fourth most common cancer and the second most deadly cancer worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing and treating gastric canc...

    Authors: Huijuan Wang, Hailong Zhang, Pengchi Deng, Chunqi Liu, Dandan Li, Hui Jie, Hu Zhang, Zongguang Zhou and Ying-Lan Zhao

    Citation: BMC Cancer 2016 16:371

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  8. Content type: Research article

    TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which sign...

    Authors: Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady and Anne Hamacher-Brady

    Citation: BMC Cancer 2016 16:355

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  9. Content type: Research article

    Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subty...

    Authors: Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt and Jean-Claude Twizere

    Citation: BMC Cancer 2016 16:335

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  10. Content type: Research article

    We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3′E)-4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a stron...

    Authors: Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri and Carla Rozzo

    Citation: BMC Cancer 2016 16:317

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  11. Content type: Research article

    Epithelial-to-mesenchymal transition (EMT) has been associated with the acquisition of metastatic potential and the resistance of cancer cells to therapeutic treatments. MCF-7 breast cancer cells engineered to co...

    Authors: Roman Mezencev, Lilya V. Matyunina, Neda Jabbari and John F. McDonald

    Citation: BMC Cancer 2016 16:236

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  12. Content type: Research article

    Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs fun...

    Authors: Hauke Thomsen, Bowang Chen, Gisella Figlioli, Rossella Elisei, Cristina Romei, Monica Cipollini, Alfonso Cristaudo, Franco Bambi, Per Hoffmann, Stefan Herms, Stefano Landi, Kari Hemminki, Federica Gemignani and Asta Försti

    Citation: BMC Cancer 2016 16:227

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  13. Content type: Research article

    “Biomarker-driven targeted therapy,” the practice of tailoring patients’ treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 m...

    Authors: Hae Ryung Chang, Hee Seo Park, Young Zoo Ahn, Seungyoon Nam, Hae Rim Jung, Sungjin Park, Sang Jin Lee, Curt Balch, Garth Powis, Ja-Lok Ku and Yon Hui Kim

    Citation: BMC Cancer 2016 16:200

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  14. Content type: Research article

    In past, numerous quantitative structure-activity relationship (QSAR) based models have been developed for predicting anticancer activity for a specific class of molecules against different cancer drug targets...

    Authors: Harinder Singh, Rahul Kumar, Sandeep Singh, Kumardeep Chaudhary, Ankur Gautam and Gajendra P. S. Raghava

    Citation: BMC Cancer 2016 16:77

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  15. Content type: Research article

    Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fus...

    Authors: Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man and Dong Sun

    Citation: BMC Cancer 2016 16:56

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  16. Content type: Research article

    The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations.

    Authors: Peter J. Mazzone, Xiao-Feng Wang, Sung Lim, Humberto Choi, James Jett, Anil Vachani, Qi Zhang, Mary Beukemann, Meredith Seeley, Ray Martino and Paul Rhodes

    Citation: BMC Cancer 2015 15:1001

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