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Survivorship

This section focuses on research related to post-treatment cancer survivors. Topics of interest include, but are not limited to, long-term studies on adverse events/side effects of cancer treatment, mortality of young cancer survivors, policy-related research that can impact the quality of care and quality of life of cancer survivors, recent guidelines for investigation of complications after treatment in child and adult cancers.

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  1. Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancie...

    Authors: Sarah F. Christensen, Robyn M. Scherber, Gina L. Mazza, Amylou C. Dueck, Nana Brochmann, Christen L. Andersen, Hans C. Hasselbalch, Ruben A. Mesa and Holly L. Geyer

    Citation: BMC Cancer 2021 21:691

    Content type: Research article

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  2. We aimed to evaluate the effects of different therapeutic options to prevent the evolution of vaginal stenosis after pelvic radiotherapy in women with cervical cancer.

    Authors: Jumara Martins, Ana Francisca Vaz, Regina Celia Grion, Lúcia Costa-Paiva and Luiz Francisco Baccaro

    Citation: BMC Cancer 2021 21:682

    Content type: Research article

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  3. Integrated social care may help to mitigate social risk factors in order to achieve more equitable health outcomes. In cancer centers certified according to the criteria set out by the German Cancer Society, e...

    Authors: Clara Breidenbach, Simone Wesselmann, Nora Tabea Sibert, Olaf Ortmann, Katrin Blankenburg, Cindy Stoklossa, Gerhard Gebauer, Marina dos Santos Guilherme, Christoph Lindner, Susanne Peschel, Friedemann Schad, Paul Strecker, Lorenz Rieger, Julia Ferencz, Sebastian Dieng and Christoph Kowalski

    Citation: BMC Cancer 2021 21:671

    Content type: Research article

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  4. Exercise is efficacious for people living after a cancer diagnosis. However, implementation of exercise interventions in real-world settings is challenging. Implementation outcomes are defined as ‘the effects ...

    Authors: Louise Czosnek, Justin Richards, Eva Zopf, Prue Cormie, Simon Rosenbaum and Nicole M. Rankin

    Citation: BMC Cancer 2021 21:643

    Content type: Research article

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  5. To compare the benefits and explore the cause of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and its combination with chemotherapy in advanced non-small-cell lu...

    Authors: Qianqian Wang, Wen Gao, Fangyan Gao, Shidai Jin, Tianyu Qu, Fan Lin, Chen Zhang, Jingya Zhang, Zhihong Zhang, Liang Chen and Renhua Guo

    Citation: BMC Cancer 2021 21:602

    Content type: Research article

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  6. Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially...

    Authors: Bharat Vaswani, Palanki Satya Dattatreya, Sagar Bhagat, Saiprasad Patil and Hanmant Barkate

    Citation: BMC Cancer 2021 21:601

    Content type: Research article

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  7. A self-help workbook is expected to support cancer patients to cope with physical and psychosocial distress, to facilitate communication with medical staff, and to improve quality of life (QOL). We conducted a...

    Authors: Toshimi Takano, Ayako Matsuda, Noriko Ishizuka, Yukinori Ozaki, Koichi Suyama, Yuko Tanabe, Yuji Miura and Eisuke Matsushima

    Citation: BMC Cancer 2021 21:588

    Content type: Research article

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  8. Research investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied. The aim of this systematic review is to identify the domains and outcomes reported in ...

    Authors: Louise O’Connor, Emily Smyth, Annemarie E. Bennett, Valerie Smith, Linda O’Neill, John V. Reynolds, Juliette Hussey and Emer Guinan

    Citation: BMC Cancer 2021 21:586

    Content type: Research article

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  9. Neuroendocrine tumors, although relatively rare in incidence, are now the second most prevalent gastrointestinal neoplasm owing to indolent disease biology. A small but significant sub-group of neuroendocrine ...

    Authors: Aman Chauhan, Satya Das, Rachel Miller, Laura Luque, Samuel N. Cheuvront, James Cloud, Zach Tarter, Fariha Siddiqui, Robert A. Ramirez and Lowell Anthony

    Citation: BMC Cancer 2021 21:580

    Content type: Research article

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  10. Metaplastic breast cancer (MBC) is a rare subtype of breast cancer, and generally associated with poor outcomes. Lymph nodes metastasis (LNM) is confirmed as a critical independent prognostic factor and determ...

    Authors: Mi Zhang, Biyuan Wang, Na Liu, Hui Wang, Juan Zhang, Lei Wu, Andi Zhao, Le Wang, Xiaoai Zhao and Jin Yang

    Citation: BMC Cancer 2021 21:565

    Content type: Research article

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  11. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of paclitaxel (PTX). There is no known prophylactic measure, although there are some reports of prevention with compression therapy ...

    Authors: Haruru Kotani, Mitsuo Terada, Makiko Mori, Nanae Horisawa, Kayoko Sugino, Ayumi Kataoka, Yayoi Adachi, Naomi Gondou, Akiyo Yoshimura, Masaya Hattori, Masataka Sawaki, Chihoko Takahata, Makiko Kobara and Hiroji Iwata

    Citation: BMC Cancer 2021 21:548

    Content type: Research article

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  12. More people are surviving a first primary cancer and experiencing a second, different cancer. However, little is known about the diagnostic journeys of patients with second primary cancer (SPC). This study exp...

    Authors: Debbie Cavers, Rhona Duff, Annemieke Bikker, Karen Barnett, Lovney Kanguru, David Weller, David H. Brewster and Christine Campbell

    Citation: BMC Cancer 2021 21:496

    Content type: Research article

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  13. Afatinib has shown favorable response rates (RRs) and longer progression free survival (PFS) in lung cancer patients harboring EGFR mutations compared with standard platinum-based chemotherapy. However, seriou...

    Authors: Yi-Chieh Chen, Ming-Ju Tsai, Mei-Hsuan Lee, Chia-Yu Kuo, Mei-Chiou Shen, Ying-Ming Tsai, Huang-Chi Chen, Jen-Yu Hung, Ming-Shyan Huang, Inn-Wen Chong and Chih-Jen Yang

    Citation: BMC Cancer 2021 21:495

    Content type: Research article

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  14. Cancer survivors who develop breast cancer as a second malignancy (BCa-2) are common. Yet, little is known about the prognosis of BCa-2 compared to first primary breast cancer (BCa-1).

    Authors: Chengshi Wang, Kejia Hu, Lei Deng, Wei He, Fang Fang, Rulla M. Tamimi and Donghao Lu

    Citation: BMC Cancer 2021 21:491

    Content type: Research article

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  15. Targeted anticancer therapies such as BCR-ABL tyrosine kinase inhibitors (TKIs) have improved outcomes for chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph +...

    Authors: Stephanie M. Smith, Himalee S. Sabnis, Rebecca Williamson Lewis, Karen E. Effinger, John Bergsagel, Briana Patterson, Ann Mertens, Kathleen M. Sakamoto, Lidia Schapira and Sharon M. Castellino

    Citation: BMC Cancer 2021 21:474

    Content type: Research article

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  16. Long non-coding RNA (lncRNA) was a vital factor in the progression and initiation of human cancers. This study found a new lncRNA, FGD5-AS1, which can inhibit EMT process, proliferation, and metastasis in vitr...

    Authors: Lin Liu, Cheng Zhang, Jizhao Wang, Xu Liu, Hangying Qu, Guangjian Zhang, Ting Liang, Jiansheng Wang and Jia Zhang

    Citation: BMC Cancer 2021 21:453

    Content type: Research article

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  17. Advances in oncology led to a substantial increase in the number of patients requiring admission to the ICU. It is significant to confirm which cancer critical patients can benefit from the ICU care like nonca...

    Authors: Zhen-nan Yuan, Hai-jun Wang, Yong Gao, Shi-ning Qu, Chu-lin Huang, Hao Wang, Hao Zhang, Quan-hui Yang and Xue-zhong Xing

    Citation: BMC Cancer 2021 21:417

    Content type: Research article

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  18. This study explores and analyzes the clinical characteristics and prognostic factors of hepatoblastoma (HB) in children under 6 years old and establishes a new risk-stratification system for individualized the...

    Authors: Tian Zhi, Wei-Ling Zhang, Yi Zhang, Hui-Min Hu, Yi-Zhuo Wang and Dong-Sheng Huang

    Citation: BMC Cancer 2021 21:397

    Content type: Research article

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  19. The survival rate after childhood cancer has improved to 80%. The majority of childhood cancer survivors (CCS) will experience late complications which require follow up care, including access to their individ...

    Authors: Helena M. Linge and Cecilia Follin

    Citation: BMC Cancer 2021 21:347

    Content type: Research article

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  20. Breast cancer is one of the main malignant tumors that threaten the lives of women, which has received more and more clinical attention worldwide. There are increasing evidences showing that the immune micro-e...

    Authors: Lin Chen, Yuxiang Dong, Yitong Pan, Yuhan Zhang, Ping Liu, Junyi Wang, Chen Chen, Jianing Lu, Yun Yu and Rong Deng

    Citation: BMC Cancer 2021 21:329

    Content type: Research article

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  21. The introduction of programmed cell death protein 1 (PD-1) blockers (i.e. nivolumab and pembrolizumab) has significantly improved the prognosis of patients with advanced melanoma. However, the long treatment d...

    Authors: E. E. A. P. Mulder, K. de Joode, S. Litière, A. J. ten Tije, K. P. M. Suijkerbuijk, M. J. Boers-Sonderen, G. A. P. Hospers, J. W. B. de Groot, A. J. M. van den Eertwegh, M. J. B. Aarts, D. Piersma, R. S. van Rijn, E. Kapiteijn, G. Vreugdenhil, F. W. P. J. van den Berkmortel, E. Oomen-de Hoop…

    Citation: BMC Cancer 2021 21:323

    Content type: Study protocol

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  22. Breast cancer (BC) presents important physical and psychological challenges that should be appropriately addressed through continuous, integrated and individualized rehabilitation programs after treatment. In ...

    Authors: Chiara Falcicchio, Domenico Di Lallo, Alessandra Fabi, Alessandro Bonucci, Maria Perrone, Andrea Pace, Ambra Corti, Luca Giacomelli and Patrizia Pugliese

    Citation: BMC Cancer 2021 21:311

    Content type: Research article

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  23. The COVID-19 pandemic has forced many cancer services to consider a transition to a remote format of delivery that is largely untested. Accordingly, we sought to perform a systematic review of the effects of r...

    Authors: Saïd Ibeggazene, Rebecca Turner, Derek Rosario and Liam Bourke

    Citation: BMC Cancer 2021 21:308

    Content type: Research article

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  24. It remains controversial whether patients with Stage II colon cancer would benefit from chemotherapy after radical surgery. This study aims to assess the real effectiveness of chemotherapy in patients with sta...

    Authors: Zhihao Lv, Yuqi Liang, Huaxi Liu and Delong Mo

    Citation: BMC Cancer 2021 21:306

    Content type: Research article

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  25. The clinical use of patient-reported outcomes as compared to inflammatory biomarkers for predicting cancer survival remains a challenge in palliative care settings. We evaluated the role of the European Organi...

    Authors: Nanako Koyama, Chikako Matsumura, Yoshihiro Shitashimizu, Morito Sako, Hideo Kurosawa, Takehisa Nomura, Yuki Eguchi, Kazuki Ohba and Yoshitaka Yano

    Citation: BMC Cancer 2021 21:304

    Content type: Research article

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  26. We aimed to study the mortality and intensity of health care in patients with advanced lung cancer who received systemic anti-cancer treatment (SACT) compared with patients who were not eligible for SACT (no-S...

    Authors: Kersti Oselin, Heti Pisarev, Keit Ilau and Raul-Allan Kiivet

    Citation: BMC Cancer 2021 21:274

    Content type: Research article

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  27. Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagno...

    Authors: Akira Sato, Keisuke Matsubayashi, Toshitaka Morishima, Kayo Nakata, Koji Kawakami and Isao Miyashiro

    Citation: BMC Cancer 2021 21:264

    Content type: Research article

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  28. Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patient...

    Authors: Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen and Asgeir Store Jakola

    Citation: BMC Cancer 2021 21:248

    Content type: Research article

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  29. Chemotherapy-induced peripheral neuropathy (CIPN) negatively affects physical function and chemotherapy dosing, yet, clinicians infrequently document CIPN assessment and/or adhere to evidence-based CIPN manage...

    Authors: Robert Knoerl, Emanuele Mazzola, Fangxin Hong, Elahe Salehi, Nadine McCleary, Jennifer Ligibel, Kaitlen Reyes and Donna L. Berry

    Citation: BMC Cancer 2021 21:236

    Content type: Research article

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  30. The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...

    Authors: Ruofei Du, Xin Wang, Lixia Ma, Leon M. Larcher, Han Tang, Huiyue Zhou, Changying Chen and Tao Wang

    Citation: BMC Cancer 2021 21:206

    Content type: Research article

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  31. Bone-targeted agents (BTAs) are widely used in the management of patients with bone metastases from solid tumors. Knowledge of the impact of their routine care use on patient-reported pain and bone pain-relate...

    Authors: Karin Ribi, Beat Thürlimann, Corinne Schär, Daniel Dietrich, Richard Cathomas, Ursina Zürrer-Härdi, Thomas von Briel, Sandro Anchisi, Pierre Bohanes, Veronika Blum, Philippe von Burg, Meinrad Mannhart, Clemens B. Caspar, Roger von Moos and Michael Mark

    Citation: BMC Cancer 2021 21:182

    Content type: Research article

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  32. Numerous studies emphasize the positive effects of physical activity on health and well-being in cancer patients. The effects of physical activity on the working lives of cancer patients have received less att...

    Authors: Rikke Rosbjerg, Robert Zachariae, Dorte Gilså Hansen, Inger Hoejris, Saskia Duijts, Nina Lykkegaard Gehr, Irene Dyhrberg Andersen and Merete Labriola

    Citation: BMC Cancer 2021 21:169

    Content type: Research article

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  33. Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom manag...

    Authors: Manuel Ester, S. Nicole Culos-Reed, Amane Abdul-Razzak, Julia T. Daun, Delaney Duchek, George Francis, Gwyn Bebb, Jennifer Black, Audra Arlain, Chelsia Gillis, Lyle Galloway and Lauren C. Capozzi

    Citation: BMC Cancer 2021 21:159

    Content type: Research article

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  34. One of the greatest success of pediatric hematology is a prominent improvement of survival in acute lymphoblastic leukemia (ALL). Therefore, special attention needs to be paid to long-term side effects of the tre...

    Authors: Slawomir Kroczka, Konrad Stepien, Izabela Witek-Motyl, Kinga Kwiecinska, Eryk Kapusta, Agnieszka Biedron, Pawel Skorek and Szymon Skoczen

    Citation: BMC Cancer 2021 21:150

    Content type: Research article

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  35. Medical centers with varying levels of expertise treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs), which are relatively rare tumors. This study assesses the impact of center volume on GEP-NET trea...

    Authors: Kiwoon Baeg, Cynthia Harris, Monica S. Naparst, Eugene Ahn, Sahityasri Thapi, Jacob Martin, Sheila Rustgi, Grace Mhango, Juan Wisnivesky and Michelle Kang Kim

    Citation: BMC Cancer 2021 21:146

    Content type: Research article

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  36. This study describes post-treatment work patterns in lymphoma survivors treated with high-dose chemotherapy with autologous stem-cell transplantation (HDT-ASCT). It aims to identify determinants for labour for...

    Authors: Kjersti Helene Hernæs, Knut B. Smeland, Unn-Merete Fagerli and Cecilie E. Kiserud

    Citation: BMC Cancer 2021 21:143

    Content type: Research article

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  37. Previous studies have reported poor survival rates in inflammatory breast cancer (IBC) patients than non-inflammatory local advanced breast cancer (non-IBC) patients. However, until now, the survival rate of I...

    Authors: Dechuang Jiao, Jingyang Zhang, Jiujun Zhu, Xuhui Guo, Yue Yang, Hui Xiao and Zhenzhen Liu

    Citation: BMC Cancer 2021 21:138

    Content type: Research article

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  38. The aim of this study was to assess the survival outcomes of cisplatin-paclitaxel chemotherapy plus bevacizumab (CPB) versus cisplatin-paclitaxel chemotherapy alone (CPA) in postmenopausal women with previousl...

    Authors: Guanghua Chu, Xiangzhen Liu, Weiguang Yu, Meiji Chen and Lingyun Dong

    Citation: BMC Cancer 2021 21:133

    Content type: Research article

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  39. The associations between fasting blood glucose and staging and overall survival of patients with pancreatic cancer are still controversial. This study aimed to investigate the association between fasting blood...

    Authors: Mingming Zhang, Xiaoru Hu, Ye Kang, Wanfeng Xu and Xianghong Yang

    Citation: BMC Cancer 2021 21:131

    Content type: Research article

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  40. Currently, the choice of treatment for individuals with metastatic soft tissue sarcomas (MSTS) presents a significant challenge to clinicians. The aim of this retrospective study was to assess the efficacy and...

    Authors: Yaolin Chen, Xiangzhen Liu, Jijun Liu, Donghua Liang, Mingdong Zhao, Weiguang Yu and Pengfei Chen

    Citation: BMC Cancer 2021 21:108

    Content type: Research article

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  41. Both breast-conserving surgery and breast reconstruction surgery are less popular in China, although they can improve patients’ quality of life. The main reason comes from the economy. There is currently no ec...

    Authors: Qing Yang, Xiaorong Zhong, Wei Zhang, Ting Luo, Ping He and Hong Zheng

    Citation: BMC Cancer 2021 21:107

    Content type: Research article

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  42. Treatment of head and neck cancer (HNC) often leads to visible and severe functional impairments. In addition, patients often suffer from a variety of psychosocial problems, significantly associated with a dec...

    Authors: C. Hammermüller, A. Hinz, A. Dietz, G. Wichmann, M. Pirlich, T. Berger, K. Zimmermann, T. Neumuth, A. Mehnert-Theuerkauf, S. Wiegand and V. Zebralla

    Citation: BMC Cancer 2021 21:94

    Content type: Research article

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  43. The successful transition of childhood cancer survivors (CCSs) from pediatric to adult long-term follow-up care is a critical phase, and determining the right time point can be challenging. We assessed the fea...

    Authors: Maria Otth, Patrick Wechsler, Sibylle Denzler, Henrik Koehler and Katrin Scheinemann

    Citation: BMC Cancer 2021 21:84

    Content type: Research article

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  44. A serious syndrome for cancer in-patients, delirium risk increases with age and medical acuity. Screening tools exist but detection is frequently delayed or missed. We test the ‘Single Question in Delirium’ (S...

    Authors: Megan B. Sands, Swapnil Sharma, Lindsay Carpenter, Andrew Hartshorn, Jessica T. Lee, Sanja Lujic, Megan E. Congdon, Angus M. Buchanan, Meera Agar and Janette L. Vardy

    Citation: BMC Cancer 2021 21:75

    Content type: Research article

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  45. Patients with lung cancer who are treated with carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen and cofactor...

    Authors: Toshinobu Hayashi, Mototsugu Shimokawa, Koichi Matsuo, Hirotoshi Iihara, Kei Kawada, Takafumi Nakano and Takashi Egawa

    Citation: BMC Cancer 2021 21:74

    Content type: Research article

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  46. Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-a...

    Authors: Dominic O’Connor, Malcolm Brown, Martin Eatock, Richard C. Turkington and Gillian Prue

    Citation: BMC Cancer 2021 21:43

    Content type: Research article

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  47. An upgraded understanding of factors (sex/estrogen) associated with survival benefit in advanced colorectal carcinoma (CRC) could improve personalised management and provide innovative insights into anti-tumou...

    Authors: Chunlong Huang, Xiaoyuan Gu, Xianshang Zeng, Baomin Chen, Weiguang Yu and Meiji Chen

    Citation: BMC Cancer 2021 21:30

    Content type: Research article

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