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Survivorship

This section focuses on research related to post-treatment cancer survivors. Topics of interest include, but are not limited to, long-term studies on adverse events/side effects of cancer treatment, mortality of young cancer survivors, policy-related research that can impact the quality of care and quality of life of cancer survivors, recent guidelines for investigation of complications after treatment in child and adult cancers.

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  1. More people are surviving a first primary cancer and experiencing a second, different cancer. However, little is known about the diagnostic journeys of patients with second primary cancer (SPC). This study exp...

    Authors: Debbie Cavers, Rhona Duff, Annemieke Bikker, Karen Barnett, Lovney Kanguru, David Weller, David H. Brewster and Christine Campbell

    Citation: BMC Cancer 2021 21:496

    Content type: Research article

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  2. Afatinib has shown favorable response rates (RRs) and longer progression free survival (PFS) in lung cancer patients harboring EGFR mutations compared with standard platinum-based chemotherapy. However, seriou...

    Authors: Yi-Chieh Chen, Ming-Ju Tsai, Mei-Hsuan Lee, Chia-Yu Kuo, Mei-Chiou Shen, Ying-Ming Tsai, Huang-Chi Chen, Jen-Yu Hung, Ming-Shyan Huang, Inn-Wen Chong and Chih-Jen Yang

    Citation: BMC Cancer 2021 21:495

    Content type: Research article

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  3. Cancer survivors who develop breast cancer as a second malignancy (BCa-2) are common. Yet, little is known about the prognosis of BCa-2 compared to first primary breast cancer (BCa-1).

    Authors: Chengshi Wang, Kejia Hu, Lei Deng, Wei He, Fang Fang, Rulla M. Tamimi and Donghao Lu

    Citation: BMC Cancer 2021 21:491

    Content type: Research article

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  4. Targeted anticancer therapies such as BCR-ABL tyrosine kinase inhibitors (TKIs) have improved outcomes for chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph +...

    Authors: Stephanie M. Smith, Himalee S. Sabnis, Rebecca Williamson Lewis, Karen E. Effinger, John Bergsagel, Briana Patterson, Ann Mertens, Kathleen M. Sakamoto, Lidia Schapira and Sharon M. Castellino

    Citation: BMC Cancer 2021 21:474

    Content type: Research article

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  5. Long non-coding RNA (lncRNA) was a vital factor in the progression and initiation of human cancers. This study found a new lncRNA, FGD5-AS1, which can inhibit EMT process, proliferation, and metastasis in vitr...

    Authors: Lin Liu, Cheng Zhang, Jizhao Wang, Xu Liu, Hangying Qu, Guangjian Zhang, Ting Liang, Jiansheng Wang and Jia Zhang

    Citation: BMC Cancer 2021 21:453

    Content type: Research article

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  6. Advances in oncology led to a substantial increase in the number of patients requiring admission to the ICU. It is significant to confirm which cancer critical patients can benefit from the ICU care like nonca...

    Authors: Zhen-nan Yuan, Hai-jun Wang, Yong Gao, Shi-ning Qu, Chu-lin Huang, Hao Wang, Hao Zhang, Quan-hui Yang and Xue-zhong Xing

    Citation: BMC Cancer 2021 21:417

    Content type: Research article

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  7. This study explores and analyzes the clinical characteristics and prognostic factors of hepatoblastoma (HB) in children under 6 years old and establishes a new risk-stratification system for individualized the...

    Authors: Tian Zhi, Wei-Ling Zhang, Yi Zhang, Hui-Min Hu, Yi-Zhuo Wang and Dong-Sheng Huang

    Citation: BMC Cancer 2021 21:397

    Content type: Research article

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  8. The survival rate after childhood cancer has improved to 80%. The majority of childhood cancer survivors (CCS) will experience late complications which require follow up care, including access to their individ...

    Authors: Helena M. Linge and Cecilia Follin

    Citation: BMC Cancer 2021 21:347

    Content type: Research article

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  9. Breast cancer is one of the main malignant tumors that threaten the lives of women, which has received more and more clinical attention worldwide. There are increasing evidences showing that the immune micro-e...

    Authors: Lin Chen, Yuxiang Dong, Yitong Pan, Yuhan Zhang, Ping Liu, Junyi Wang, Chen Chen, Jianing Lu, Yun Yu and Rong Deng

    Citation: BMC Cancer 2021 21:329

    Content type: Research article

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  10. The introduction of programmed cell death protein 1 (PD-1) blockers (i.e. nivolumab and pembrolizumab) has significantly improved the prognosis of patients with advanced melanoma. However, the long treatment d...

    Authors: E. E. A. P. Mulder, K. de Joode, S. Litière, A. J. ten Tije, K. P. M. Suijkerbuijk, M. J. Boers-Sonderen, G. A. P. Hospers, J. W. B. de Groot, A. J. M. van den Eertwegh, M. J. B. Aarts, D. Piersma, R. S. van Rijn, E. Kapiteijn, G. Vreugdenhil, F. W. P. J. van den Berkmortel, E. Oomen-de Hoop…

    Citation: BMC Cancer 2021 21:323

    Content type: Study protocol

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  11. Breast cancer (BC) presents important physical and psychological challenges that should be appropriately addressed through continuous, integrated and individualized rehabilitation programs after treatment. In ...

    Authors: Chiara Falcicchio, Domenico Di Lallo, Alessandra Fabi, Alessandro Bonucci, Maria Perrone, Andrea Pace, Ambra Corti, Luca Giacomelli and Patrizia Pugliese

    Citation: BMC Cancer 2021 21:311

    Content type: Research article

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  12. The COVID-19 pandemic has forced many cancer services to consider a transition to a remote format of delivery that is largely untested. Accordingly, we sought to perform a systematic review of the effects of r...

    Authors: Saïd Ibeggazene, Rebecca Turner, Derek Rosario and Liam Bourke

    Citation: BMC Cancer 2021 21:308

    Content type: Research article

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  13. It remains controversial whether patients with Stage II colon cancer would benefit from chemotherapy after radical surgery. This study aims to assess the real effectiveness of chemotherapy in patients with sta...

    Authors: Zhihao Lv, Yuqi Liang, Huaxi Liu and Delong Mo

    Citation: BMC Cancer 2021 21:306

    Content type: Research article

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  14. The clinical use of patient-reported outcomes as compared to inflammatory biomarkers for predicting cancer survival remains a challenge in palliative care settings. We evaluated the role of the European Organi...

    Authors: Nanako Koyama, Chikako Matsumura, Yoshihiro Shitashimizu, Morito Sako, Hideo Kurosawa, Takehisa Nomura, Yuki Eguchi, Kazuki Ohba and Yoshitaka Yano

    Citation: BMC Cancer 2021 21:304

    Content type: Research article

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  15. We aimed to study the mortality and intensity of health care in patients with advanced lung cancer who received systemic anti-cancer treatment (SACT) compared with patients who were not eligible for SACT (no-S...

    Authors: Kersti Oselin, Heti Pisarev, Keit Ilau and Raul-Allan Kiivet

    Citation: BMC Cancer 2021 21:274

    Content type: Research article

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  16. Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagno...

    Authors: Akira Sato, Keisuke Matsubayashi, Toshitaka Morishima, Kayo Nakata, Koji Kawakami and Isao Miyashiro

    Citation: BMC Cancer 2021 21:264

    Content type: Research article

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  17. Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patient...

    Authors: Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen and Asgeir Store Jakola

    Citation: BMC Cancer 2021 21:248

    Content type: Research article

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  18. Chemotherapy-induced peripheral neuropathy (CIPN) negatively affects physical function and chemotherapy dosing, yet, clinicians infrequently document CIPN assessment and/or adhere to evidence-based CIPN manage...

    Authors: Robert Knoerl, Emanuele Mazzola, Fangxin Hong, Elahe Salehi, Nadine McCleary, Jennifer Ligibel, Kaitlen Reyes and Donna L. Berry

    Citation: BMC Cancer 2021 21:236

    Content type: Research article

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  19. The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...

    Authors: Ruofei Du, Xin Wang, Lixia Ma, Leon M. Larcher, Han Tang, Huiyue Zhou, Changying Chen and Tao Wang

    Citation: BMC Cancer 2021 21:206

    Content type: Research article

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  21. Bone-targeted agents (BTAs) are widely used in the management of patients with bone metastases from solid tumors. Knowledge of the impact of their routine care use on patient-reported pain and bone pain-relate...

    Authors: Karin Ribi, Beat Thürlimann, Corinne Schär, Daniel Dietrich, Richard Cathomas, Ursina Zürrer-Härdi, Thomas von Briel, Sandro Anchisi, Pierre Bohanes, Veronika Blum, Philippe von Burg, Meinrad Mannhart, Clemens B. Caspar, Roger von Moos and Michael Mark

    Citation: BMC Cancer 2021 21:182

    Content type: Research article

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  22. Numerous studies emphasize the positive effects of physical activity on health and well-being in cancer patients. The effects of physical activity on the working lives of cancer patients have received less att...

    Authors: Rikke Rosbjerg, Robert Zachariae, Dorte Gilså Hansen, Inger Hoejris, Saskia Duijts, Nina Lykkegaard Gehr, Irene Dyhrberg Andersen and Merete Labriola

    Citation: BMC Cancer 2021 21:169

    Content type: Research article

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  23. Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom manag...

    Authors: Manuel Ester, S. Nicole Culos-Reed, Amane Abdul-Razzak, Julia T. Daun, Delaney Duchek, George Francis, Gwyn Bebb, Jennifer Black, Audra Arlain, Chelsia Gillis, Lyle Galloway and Lauren C. Capozzi

    Citation: BMC Cancer 2021 21:159

    Content type: Research article

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  24. One of the greatest success of pediatric hematology is a prominent improvement of survival in acute lymphoblastic leukemia (ALL). Therefore, special attention needs to be paid to long-term side effects of the tre...

    Authors: Slawomir Kroczka, Konrad Stepien, Izabela Witek-Motyl, Kinga Kwiecinska, Eryk Kapusta, Agnieszka Biedron, Pawel Skorek and Szymon Skoczen

    Citation: BMC Cancer 2021 21:150

    Content type: Research article

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  25. Medical centers with varying levels of expertise treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs), which are relatively rare tumors. This study assesses the impact of center volume on GEP-NET trea...

    Authors: Kiwoon Baeg, Cynthia Harris, Monica S. Naparst, Eugene Ahn, Sahityasri Thapi, Jacob Martin, Sheila Rustgi, Grace Mhango, Juan Wisnivesky and Michelle Kang Kim

    Citation: BMC Cancer 2021 21:146

    Content type: Research article

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  26. This study describes post-treatment work patterns in lymphoma survivors treated with high-dose chemotherapy with autologous stem-cell transplantation (HDT-ASCT). It aims to identify determinants for labour for...

    Authors: Kjersti Helene Hernæs, Knut B. Smeland, Unn-Merete Fagerli and Cecilie E. Kiserud

    Citation: BMC Cancer 2021 21:143

    Content type: Research article

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  27. Previous studies have reported poor survival rates in inflammatory breast cancer (IBC) patients than non-inflammatory local advanced breast cancer (non-IBC) patients. However, until now, the survival rate of I...

    Authors: Dechuang Jiao, Jingyang Zhang, Jiujun Zhu, Xuhui Guo, Yue Yang, Hui Xiao and Zhenzhen Liu

    Citation: BMC Cancer 2021 21:138

    Content type: Research article

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  28. The aim of this study was to assess the survival outcomes of cisplatin-paclitaxel chemotherapy plus bevacizumab (CPB) versus cisplatin-paclitaxel chemotherapy alone (CPA) in postmenopausal women with previousl...

    Authors: Guanghua Chu, Xiangzhen Liu, Weiguang Yu, Meiji Chen and Lingyun Dong

    Citation: BMC Cancer 2021 21:133

    Content type: Research article

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  29. The associations between fasting blood glucose and staging and overall survival of patients with pancreatic cancer are still controversial. This study aimed to investigate the association between fasting blood...

    Authors: Mingming Zhang, Xiaoru Hu, Ye Kang, Wanfeng Xu and Xianghong Yang

    Citation: BMC Cancer 2021 21:131

    Content type: Research article

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  30. Currently, the choice of treatment for individuals with metastatic soft tissue sarcomas (MSTS) presents a significant challenge to clinicians. The aim of this retrospective study was to assess the efficacy and...

    Authors: Yaolin Chen, Xiangzhen Liu, Jijun Liu, Donghua Liang, Mingdong Zhao, Weiguang Yu and Pengfei Chen

    Citation: BMC Cancer 2021 21:108

    Content type: Research article

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  31. Both breast-conserving surgery and breast reconstruction surgery are less popular in China, although they can improve patients’ quality of life. The main reason comes from the economy. There is currently no ec...

    Authors: Qing Yang, Xiaorong Zhong, Wei Zhang, Ting Luo, Ping He and Hong Zheng

    Citation: BMC Cancer 2021 21:107

    Content type: Research article

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  32. Treatment of head and neck cancer (HNC) often leads to visible and severe functional impairments. In addition, patients often suffer from a variety of psychosocial problems, significantly associated with a dec...

    Authors: C. Hammermüller, A. Hinz, A. Dietz, G. Wichmann, M. Pirlich, T. Berger, K. Zimmermann, T. Neumuth, A. Mehnert-Theuerkauf, S. Wiegand and V. Zebralla

    Citation: BMC Cancer 2021 21:94

    Content type: Research article

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  34. The successful transition of childhood cancer survivors (CCSs) from pediatric to adult long-term follow-up care is a critical phase, and determining the right time point can be challenging. We assessed the fea...

    Authors: Maria Otth, Patrick Wechsler, Sibylle Denzler, Henrik Koehler and Katrin Scheinemann

    Citation: BMC Cancer 2021 21:84

    Content type: Research article

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  35. A serious syndrome for cancer in-patients, delirium risk increases with age and medical acuity. Screening tools exist but detection is frequently delayed or missed. We test the ‘Single Question in Delirium’ (S...

    Authors: Megan B. Sands, Swapnil Sharma, Lindsay Carpenter, Andrew Hartshorn, Jessica T. Lee, Sanja Lujic, Megan E. Congdon, Angus M. Buchanan, Meera Agar and Janette L. Vardy

    Citation: BMC Cancer 2021 21:75

    Content type: Research article

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  36. Patients with lung cancer who are treated with carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen and cofactor...

    Authors: Toshinobu Hayashi, Mototsugu Shimokawa, Koichi Matsuo, Hirotoshi Iihara, Kei Kawada, Takafumi Nakano and Takashi Egawa

    Citation: BMC Cancer 2021 21:74

    Content type: Research article

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  37. Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-a...

    Authors: Dominic O’Connor, Malcolm Brown, Martin Eatock, Richard C. Turkington and Gillian Prue

    Citation: BMC Cancer 2021 21:43

    Content type: Research article

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  38. An upgraded understanding of factors (sex/estrogen) associated with survival benefit in advanced colorectal carcinoma (CRC) could improve personalised management and provide innovative insights into anti-tumou...

    Authors: Chunlong Huang, Xiaoyuan Gu, Xianshang Zeng, Baomin Chen, Weiguang Yu and Meiji Chen

    Citation: BMC Cancer 2021 21:30

    Content type: Research article

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  40. Kidney cancer (KC) is associated with cardiovascular regulation disorder and easily leads to cardiovascular and cerebrovascular death (CCD), which is one of the major causes of death in patients with KC, espec...

    Authors: Xiaofei Mo, Mingge Zhou, Hui Yan, Xueqin Chen and Yuetao Wang

    Citation: BMC Cancer 2021 21:13

    Content type: Research article

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  41. At intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated w...

    Authors: Hubert Gheerbrant, Jean-François Timsit, Nicolas Terzi, Stéphane Ruckly, Mathieu Laramas, Matteo Giaj Levra, Emmanuelle Jacquet, Loic Falque, Denis Moro-Sibilot and Anne-Claire Toffart

    Citation: BMC Cancer 2021 21:9

    Content type: Research article

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  42. Immune checkpoint inhibitors and targeted therapies are approved for adjuvant treatment of patients with resected melanoma; however, they have not been compared in randomized controlled trials (RCTs). We compa...

    Authors: Kabirraaj Toor, Mark R. Middleton, Keith Chan, Adenike Amadi, Andriy Moshyk and Srividya Kotapati

    Citation: BMC Cancer 2021 21:3

    Content type: Research article

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  43. This study examined current physical activity levels and preferences for exercise settings and activities among adult survivors of childhood cancers as a strategy to inform the feasibility and design of such p...

    Authors: Denise Rokitka, Jennifer Heffler, Michael Zevon, Caleb Kitcho, Jennifer Schweitzer, Elisa M. Rodriguez and Martin C. Mahoney

    Citation: BMC Cancer 2021 21:1

    Content type: Research article

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  45. Little is known about treatment expectations of patients with spinal metastases undergoing radiotherapy and/or surgery. Assuming that patients with spinal metastases share characteristics with patients who had...

    Authors: R. Gal, D. Oostinga, H. Wessels, J. J. Verlaan, R. Charest-Morin, C. G. Fisher, H. M. Verkooijen and A. L. Versteeg

    Citation: BMC Cancer 2020 20:1212

    Content type: Research article

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  46. Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the i...

    Authors: Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan and Tao Chen

    Citation: BMC Cancer 2020 20:1161

    Content type: Research article

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  47. The aim of this study was to translate and linguistically validate the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) into...

    Authors: Cheng KKF, S. A. Mitchell, N. Chan, E. Ang, W. Tam and R. Kanesvaran

    Citation: BMC Cancer 2020 20:1153

    Content type: Research article

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  48. Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and qu...

    Authors: Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen and Xiao Guo

    Citation: BMC Cancer 2020 20:1148

    Content type: Research article

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  49. Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients; the most common pathological type of BC is infiltrating duct carcinoma (IDC). Some nomograms ...

    Authors: Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao and Chanchan Hu

    Citation: BMC Cancer 2020 20:1145

    Content type: Research article

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  50. Prehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate rec...

    Authors: Erik Rupnik, Matevz Skerget, Matjaz Sever, Irena Preloznik Zupan, Maja Ogrinec, Barbara Ursic, Natasa Kos, Peter Cernelc and Samo Zver

    Citation: BMC Cancer 2020 20:1142

    Content type: Research article

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BMC Cancer

ISSN: 1471-2407

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