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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 5 of 10

  1. Content type: Research article

    Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction ...

    Authors: Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras and Kuno Lehmann

    Citation: BMC Cancer 2018 18:548

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  2. Content type: Research article

    Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous r...

    Authors: Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong and Young Deuk Choi

    Citation: BMC Cancer 2018 18:545

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  3. Content type: Research article

    Malnutrition and weight loss are commonly observed in patients with pancreatic cancer and contribute to poor survival. Pancreatic exocrine insufficiency (PEI), which can be caused by ductal obstruction by a tu...

    Authors: Juan Enrique Domínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader and Julio Iglesias-Garcia

    Citation: BMC Cancer 2018 18:534

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  4. Content type: Research article

    Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpecte...

    Authors: Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni and Cosimo Sperti

    Citation: BMC Cancer 2018 18:531

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  5. Content type: Research article

    Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer. The prognosis of women with NECC is poor and there is no standardized therapy for this type of malignancy based on controlled...

    Authors: Clemens B. Tempfer, Iris Tischoff, Askin Dogan, Ziad Hilal, Beate Schultheis, Peter Kern and Günther A. Rezniczek

    Citation: BMC Cancer 2018 18:530

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  6. Content type: Case report

    Glomus tumor is a rare benign neoplasm, which most frequently occurs in the subungual regions of digits. Tumor rupture and infection occurred in one patient with a glomus tumor have never been reported.

    Authors: Hui Lu, Li Feng Chen and Qiang Chen

    Citation: BMC Cancer 2018 18:505

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  7. Content type: Case report

    Ewing’s sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing’s sarcoma at the distal end of the tibia....

    Authors: Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka and Toshikazu Kubo

    Citation: BMC Cancer 2018 18:503

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  8. Content type: Case report

    Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa h...

    Authors: Samiullah Khan, Lan-ping Zhu, Yujie Zhang, Xin Chen and Bang-mao Wang

    Citation: BMC Cancer 2018 18:502

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  9. Content type: Research article

    There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS),...

    Authors: Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida and Takao Kamai

    Citation: BMC Cancer 2018 18:493

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  10. Content type: Research article

    Intravenous chemotherapy (IVC) and intra-arterial chemotherapy (IAC) have become the primary treatments for retinoblastoma; however, some controversy remains over which method is more effective. We conducted a...

    Authors: Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Wenhui Huang, Hua Jiang, Jiejun Xia and Shuixing Zhang

    Citation: BMC Cancer 2018 18:486

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  11. Content type: Case report

    Calcification in primary gastric cancer is very rare. In this report, we describe the computerized tomography (CT) changes in calcification in a patient with locally advanced signet-ring gastric cancer treated...

    Authors: Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang and Long Huang

    Citation: BMC Cancer 2018 18:474

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  12. Content type: Research article

    Clinical trial (CT) participation may confer access to new, potentially active agents before their general availability. This study aimed to investigate the potential survival benefit of participation in inves...

    Authors: Kyo Chul Koo, Jong Soo Lee, Jong Won Kim, Kyung Suk Han, Kwang Suk Lee, Do Kyung Kim, Yoon Soo Ha, Koon Ho Rha, Sung Joon Hong and Byung Ha Chung

    Citation: BMC Cancer 2018 18:468

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  13. Content type: Research article

    The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primari...

    Authors: Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin and Zhenyu Zhang

    Citation: BMC Cancer 2018 18:461

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  14. Content type: Research article

    Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signali...

    Authors: Fei Ji, Zhi-heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang and Yun-Peng Hua

    Citation: BMC Cancer 2018 18:460

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  15. Content type: Study protocol

    Cosmetic result in breast cancer surgery is gaining increased interest. Currently, some 30–40% of the patients treated with breast conserving surgery (BCS) are dissatisfied with their final cosmetic result. In...

    Authors: Coriene J. L. M. Catsman, Martinus A. Beek, Adri C. Voogd, Paul G. H. Mulder and Ernest J. T. Luiten

    Citation: BMC Cancer 2018 18:456

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  16. Content type: Study protocol

    Initial staging of gastric cancer consists of computed tomography (CT) and gastroscopy. In locally advanced (cT3–4) gastric cancer, fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT or PET) a...

    Authors: H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det…

    Citation: BMC Cancer 2018 18:450

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  17. Content type: Research article

    Patients with recurrent malignant epithelioid mesothelioma (MM) after surgery and standard chemotherapy with cisplatin and pemetrexed have limited treatment options.

    Authors: Urs Giger-Pabst, Cédric Demtröder, Thomas A. Falkenstein, Mehdi Ouaissi, Thorsten O. Götze, Günther A. Rezniczek and Clemens B. Tempfer

    Citation: BMC Cancer 2018 18:442

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  18. Content type: Research article

    We aimed to investigate the roles of hemoglobin (Hb) concentrations and dynamic change during treatment on outcomes of patients with extremity osteosarcoma.

    Authors: Jian Tu, Lili Wen, Zijun Huo, Bo Wang, Yongqian Wang, Hongyi Liao, Weihai Liu, Xian Zhong, Jianqiu Kong, Mengqi Wang, Gang Huang, Junqiang Yin, Xianbiao Xie and Jingnan Shen

    Citation: BMC Cancer 2018 18:428

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  19. Content type: Research article

    The prognosis of patients with pathologic stage T3a renal cell carcinoma (RCC) that is up-staged from a small renal tumor remains controversial. We evaluated the prognosis of patients with RCC who were up-stag...

    Authors: Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak and Sung Kyu Hong

    Citation: BMC Cancer 2018 18:427

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  20. Content type: Research article

    Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking is usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are ...

    Authors: Michaela Ramser, Simone Eichelberger, Silvio Däster, Benjamin Weixler, Marko Kraljević, Robert Mechera, Athanasios Tampakis, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser and Gad Singer

    Citation: BMC Cancer 2018 18:425

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  21. Content type: Research article

    Extramammary Paget disease (EMPD) is a rare malignant dermatosis with poorly defined outcomes. We investigated clinical characteristics of invasive EMPD at different anatomic sites and by subject demographics ...

    Authors: Haijun Yao, Minkai Xie, Shibo Fu, Jianhua Guo, Yubing Peng, Zhikang Cai, Yueqing Jiang, Dachao Zheng and Zhong Wang

    Citation: BMC Cancer 2018 18:403

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  22. Content type: Research article

    Twelve months treatment is the current standard of care for adjuvant trastuzumab in patients with HER2 positive early breast cancer however the optimal duration is not known. Persephone is a non-inferiority ra...

    Authors: Louise Hiller, Janet A. Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L. Howe, David A. Cameron, David Miles, Andrew M. Wardley and Helena M. Earl

    Citation: BMC Cancer 2018 18:391

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  23. Content type: Research article

    Hyperfibrinogenemia is increasingly being recognized as an important risk factor related to cancer stage, development and outcomes. We evaluated whether preoperative serum fibrinogen levels predict recurrence ...

    Authors: Lei Jianyong, Li Zhihui, Gong Rixiang and Zhu Jingqiang

    Citation: BMC Cancer 2018 18:390

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  24. Content type: Research article

    This study aimed to systematically review and to meta-analyse the accuracy of digital breast tomosynthesis (DBT) versus digital mammography (DM) in women with mammographically dense breasts in screening and di...

    Authors: Xuan-Anh Phi, Alberto Tagliafico, Nehmat Houssami, Marcel J. W. Greuter and Geertruida H. de Bock

    Citation: BMC Cancer 2018 18:380

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  25. Content type: Research article

    It is still controversial whether laparoscopy-assisted colectomy (LAC) is suitable for patients with stage T4 colon cancer. This study aimed to compare the short- and long-term outcomes of LAC and open colecto...

    Authors: Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao and Guoxin Li

    Citation: BMC Cancer 2018 18:370

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  26. Content type: Study protocol

    Recent retrospective data suggest that neoadjuvant androgen deprivation therapy can improve the prognosis of high-risk prostate cancer (PCa) patients. Novel androgen receptor pathway inhibitors are nowadays av...

    Authors: Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans and Steven Joniau

    Citation: BMC Cancer 2018 18:354

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  27. Content type: Case report

    Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targ...

    Authors: Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan and Lu Pan

    Citation: BMC Cancer 2018 18:338

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  28. Content type: Research article

    The incidence of colorectal cancer in adolescent and young adult patients is increasing. However, survival and clinical features of young patients, especially those with stage IV disease, relative to adult pat...

    Authors: Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku and Yukihide Kanemitsu

    Citation: BMC Cancer 2018 18:334

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  29. Content type: Research article

    The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of...

    Authors: Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin and Shengping Li

    Citation: BMC Cancer 2018 18:327

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  30. Content type: Research article

    Age is an important prognostic factor in papillary thyroid cancer (PTC), with better survival observed in patients < 45 years of age, regardless of stage. Although the impact of increasing age on PTC-related s...

    Authors: Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte and John H. Yim

    Citation: BMC Cancer 2018 18:316

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  31. Content type: Research article

    Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognos...

    Authors: Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu and Jiejie Xu

    Citation: BMC Cancer 2018 18:313

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  32. Content type: Research article

    Liposarcomas are the second most common type of soft tissue sarcomas, 30–50% of these are of myxoid subtype. The aim of this retrospective study was to analyze the local control rate, the metastatic pattern an...

    Authors: Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson and Alexander Klein

    Citation: BMC Cancer 2018 18:304

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  33. Content type: Case report

    Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare.

    Authors: Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone and Maria Abbondanza Pantaleo

    Citation: BMC Cancer 2018 18:301

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  34. Content type: Case report

    Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse pr...

    Authors: Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani and Satoshi Ito

    Citation: BMC Cancer 2018 18:300

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  35. Content type: Research article

    The nomogram of the Barcelona Clinic Liver Cancer (BCLC) for hepatocellular carcinoma (HCC) has been used for outcome prediction. Patients with BCLC stage C HCC often undergo anti-cancer therapy against curren...

    Authors: Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang and Teh-Ia Huo

    Citation: BMC Cancer 2018 18:289

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  36. Content type: Research article

    An ideal tumor marker should be capable of being detected at any stage of the disease. However, gastric cancer patients do not always have elevated serum carcinoembryonic antigen (CEA) levels, even in advanced...

    Authors: Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura and Yasunari Kawabata

    Citation: BMC Cancer 2018 18:285

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  37. Content type: Research article

    Microvascular invasion (MVI) is well established as a negative prognostic factor for hepatocelluar carcinoma (HCC). However, its prognostic value in different subgroups of Barcelona Clinical Liver Cancer (BCLC...

    Authors: Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang and Changli Lu

    Citation: BMC Cancer 2018 18:278

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  38. Content type: Research article

    Cancer surgery can promote tumour metastases and worsen prognosis, however, the effect of perioperative complications on metastatic disease remains unclear. In this study we sought to evaluate the effect of co...

    Authors: Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy and Rebecca C. Auer

    Citation: BMC Cancer 2018 18:277

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    The Correction to this article has been published in BMC Cancer 2018 18:437

  40. Content type: Case report

    After orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), recurrent HCC mostly develops within 2 years. All cases of de novo HCC described so far occurred later than 2 years after OLT. Prev...

    Authors: Giuliano Ramadori, Patrizia Bosio, Federico Moriconi and Ihtzaz A. Malik

    Citation: BMC Cancer 2018 18:257

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  41. Content type: Research article

    This study aimed to investigate the safety of sorafenib for the treatment of unresectable hepatocellular carcinoma in Chinese patients.

    Authors: Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu…

    Citation: BMC Cancer 2018 18:247

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  42. Content type: Research article

    There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatoc...

    Authors: Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang and Ming-qing Xu

    Citation: BMC Cancer 2018 18:216

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  43. Content type: Research article

    The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM). Using pre-operative MRI techniques to predict MGMT promo...

    Authors: Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang…

    Citation: BMC Cancer 2018 18:215

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  45. Content type: Research article

    Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ult...

    Authors: Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown and M. J. Kerin

    Citation: BMC Cancer 2018 18:203

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    The Correction to this article has been published in BMC Cancer 2018 18:282

  47. Content type: Study protocol

    Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6...

    Authors: A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo…

    Citation: BMC Cancer 2018 18:183

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  48. Content type: Research article

    The association between body mass index (BMI) and clinical outcomes of gastric cancer were still under debate. The aim of the present study was to investigate the impact of BMI on intraoperative conditions, po...

    Authors: Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian and Hongwei Zhang

    Citation: BMC Cancer 2018 18:151

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  49. Content type: Study protocol

    Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection ...

    Authors: Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef…

    Citation: BMC Cancer 2018 18:142

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  50. Content type: Study protocol

    While the incidence of esophageal and gastric cancers is increasing, the prognosis of these cancers remains bleak. Endoscopy and surgery are the standard treatments for localized tumors, but multimodal treatme...

    Authors: Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe and Antoine Adenis

    Citation: BMC Cancer 2018 18:139

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