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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 5 of 8

  1. Content type: Research article

    On conventional diagnostic imaging, the features of radiation necrosis (RN) are similar to those of local recurrence (LR) of brain metastases (BM). 11C–methionine positron emission tomography (MET-PET) is reporte...

    Authors: Shoji Yomo and Kazuhiro Oguchi

    Citation: BMC Cancer 2017 17:713

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  2. Content type: Case report

    Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting t...

    Authors: Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu and Biguang Tuo

    Citation: BMC Cancer 2017 17:712

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  3. Content type: Research article

    Our research aimed to investigate whether lymphadenectomy was required in patients with intermediate-risk endometrioid endometrial cancer (EEC).

    Authors: Menghan Zhu, Nan Jia, Feifei Huang, Xiaoxia Liu, Yuqing Zhao, Xiang Tao, Wei Jiang, Qin Li and Weiwei Feng

    Citation: BMC Cancer 2017 17:696

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  4. Content type: Study protocol

    In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Authors: Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh

    Citation: BMC Cancer 2017 17:649

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  5. Content type: Research article

    Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear.

    Authors: Fei-Xiang Wu, Jie Chen, Tao Bai, Shao-Liang Zhu, Tian-Bo Yang, Lu-Nan Qi, Ling Zou, Zi-Hui Li, Jia-Zhou Ye and Le-Qun Li

    Citation: BMC Cancer 2017 17:645

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  6. Content type: Case report

    A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We ...

    Authors: Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely and Hajnalka Vago

    Citation: BMC Cancer 2017 17:612

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  7. Content type: Research article

    Larynx preservation (LP) is recommended for up to low-volume T4 laryngeal cancer as an evidence-based treatment option that does not compromise survival. However, a reevaluation of the current literature raise...

    Authors: Gerhard Dyckhoff, Peter K. Plinkert and Heribert Ramroth

    Citation: BMC Cancer 2017 17:609

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  8. Content type: Case report

    The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response ra...

    Authors: Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens and Philippe G. Jorens

    Citation: BMC Cancer 2017 17:586

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  9. Content type: Research article

    Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked to tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of r...

    Authors: Myung-Giun Noh, Se-Jeong Oh, Eun-Jung Ahn, Yeong-Jin Kim, Tae-Young Jung, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Kyung-Hwa Lee and Kyung-Sub Moon

    Citation: BMC Cancer 2017 17:583

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  10. Content type: Research article

    The Cancer Genome Atlas Research Network reported that high-grade serous carcinoma (HGSC) can be classified based on gene expression profiles into four subtypes, termed “immunoreactive,” “differentiated,” “pro...

    Authors: Takuma Ohsuga, Ken Yamaguchi, Aki Kido, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondoh, Tsukasa Baba, Ikuo Konishi and Noriomi Matsumura

    Citation: BMC Cancer 2017 17:580

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  11. Content type: Case report

    Neurofibromatosis type 1 is a relatively common inherited disorder. Patients with neurofibromatosis type 1 are at high risk of developing neurogenic, neuroendocrine and mesenchymal intra-abdominal tumors. Alth...

    Authors: Nihed Abdessayed, Rahul Gupta, Sarra Mestiri, Ahlem Bdioui, Mounir Trimech and Moncef Mokni

    Citation: BMC Cancer 2017 17:579

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  12. Content type: Research article

    Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF)...

    Authors: Anders Christensen, Katalin Kiss, Giedrius Lelkaitis, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Julie Lyng Forman, Anne Lyngholm Sørensen, David Hebbelstrup Jensen, Andreas Kjaer and Christian von Buchwald

    Citation: BMC Cancer 2017 17:572

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  13. Content type: Research article

    The relationship between the number of harvested lymph nodes (HLNs) and prognosis of gastric cancer patients without an involvement of lymph nodes has not been well-evaluated. The objective of this study is to...

    Authors: Xin Ji, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia and Jia-Fu Ji

    Citation: BMC Cancer 2017 17:558

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  14. Content type: Study protocol

    Following esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of esop...

    Authors: Jonna K. van Vulpen, Peter D. Siersema, Richard van Hillegersberg, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Eric J. Hazebroek, Camiel Rosman, Carlo C. G. Schippers, Elles Steenhagen, Petra H. M. Peeters and Anne M. May

    Citation: BMC Cancer 2017 17:552

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  15. Content type: Research article

    The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor...

    Authors: Gang Li, Jianpeng Yu, Hualin Song, Shimiao Zhu, Libin Sun, Zhiqun Shang and Yuanjie Niu

    Citation: BMC Cancer 2017 17:530

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  16. Content type: Research article

    Solid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we repor...

    Authors: Lina Zhang, Ling Zhuang, Chang Shi, Yanwei Miao, Weisheng Zhang, Qingwei Song, Jianyun Kang, Zhijin Lang, Xuegang Xin, Ailian Liu and Jiani Hu

    Citation: BMC Cancer 2017 17:525

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  17. Content type: Research article

    Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can b...

    Authors: Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht and Ulrich Steger

    Citation: BMC Cancer 2017 17:522

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  18. Content type: Research article

    Although several studies have been conducted on the role of surgery in localized neuroblastoma, the impact of surgical timing and extent of primary tumor resection on outcome in high-risk patients remains cont...

    Authors: Janina Fischer, Alexandra Pohl, Ruth Volland, Barbara Hero, Martin Dübbers, Grigore Cernaianu, Frank Berthold, Dietrich von Schweinitz and Thorsten Simon

    Citation: BMC Cancer 2017 17:520

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  19. Content type: Research article

    To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cerv...

    Authors: Jing Li, Ni-ya Ning, Qun-xian Rao, Rong Chen, Li-juan Wang and Zhong-qiu Lin

    Citation: BMC Cancer 2017 17:517

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  20. Content type: Study protocol

    Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for C...

    Authors: Matthew H. G. Katz, Fang-Shu Ou, Joseph M. Herman, Syed A. Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H. Schwartz, Wendy Frankel, Eric Collisson, Eugene J. Koay, JoLeen M. Hubbard, James L. Leenstra, Jeffrey Meyerhardt…

    Citation: BMC Cancer 2017 17:505

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  21. Content type: Case report

    Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on ...

    Authors: Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma. Reyes Oliver-Perez and Jesús S. Jiménez-López

    Citation: BMC Cancer 2017 17:503

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  22. Content type: Research article

    Vinflunine is the only chemotherapeutic agent shown to improve survival in platinum-refractory patients with metastatic transitional cell carcinoma of the urothelium (TCCU) in a phase III clinical trial, which...

    Authors: Rodolfo Passalacqua, Silvia Lazzarelli, Maddalena Donini, Rodolfo Montironi, Rosa Tambaro, Ugo De Giorgi, Sandro Pignata, Raffaella Palumbo, Giovanni Luca Ceresoli, Gianluca Del Conte, Giuseppe Tonini, Franco Morelli, Franco Nolè, Stefano Panni, Ermanno Rondini, Annalisa Guida…

    Citation: BMC Cancer 2017 17:493

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  23. Content type: Research article

    This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovar...

    Authors: Kyung Jin Eoh, Jung Won Yoon, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2017 17:481

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  24. Content type: Review

    Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer ...

    Authors: Ramon Garza III, Roman Skoracki, Karen Hock and Stephen P. Povoski

    Citation: BMC Cancer 2017 17:468

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  25. Content type: Research article

    Previous nomograms for intrahepatic cholangiocarcinoma (ICC) were conducted to predict overall survival, which could be influenced by various factors. Herein, we conducted our nomogram to predict recurrence of...

    Authors: Seogsong Jeong, Qingbao Cheng, Lifeng Huang, Jian Wang, Meng Sha, Ying Tong, Lei Xia, Longzhi Han, Zhifeng Xi, Jianjun Zhang, Xiaoni Kong, Jinyang Gu and Qiang Xia

    Citation: BMC Cancer 2017 17:464

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  26. Content type: Study protocol

    Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of th...

    Authors: L. M. van Roozendaal, M. L. G. Vane, T. van Dalen, J. A. van der Hage, L. J. A. Strobbe, L. J. Boersma, S. C. Linn, M. B. I. Lobbes, P. M. P. Poortmans, V. C. G. Tjan-Heijnen, K. K. B. T. Van de Vijver, J. de Vries, A. H. Westenberg, A. G. H. Kessels, J. H. W. de Wilt and M. L. Smidt

    Citation: BMC Cancer 2017 17:459

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  27. Content type: Research article

    The pathological and oncological outcomes of retro-pubic radical prostatectomy (RRP) and robot-assisted radical prostatectomy (RARP) have not been sufficiently investigated.

    Authors: Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Taguchi, Yuta Yamada, Toru Sugihara, Tohru Nakagawa, Aya Niimi, Haruki Kume, Yasuhiko Igawa and Yukio Homma

    Citation: BMC Cancer 2017 17:454

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  28. Content type: Study protocol

    Neoadjuvant chemoradiation is not recommended as an approach for treatment of esophageal squamous cell carcinoma due to its significant postoperative mortality. However, it is assumed the combination of neoadj...

    Authors: Han Tang, Lijie Tan, Yaxing Shen, Hao Wang, Miao Lin, Mingxiang Feng, Songtao Xu, Weigang Guo, Cheng Qian, Tianshu Liu, Zhaochong Zeng, Yingyong Hou, Zhentao Yu, Hongjing Jiang, Zhigang Li, Chun Chen…

    Citation: BMC Cancer 2017 17:450

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  29. Content type: Research article

    Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment out...

    Authors: Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita and Kaoru Ogawa

    Citation: BMC Cancer 2017 17:445

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  30. Content type: Study protocol

    Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of poste...

    Authors: Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lönnqvist, René Mathiasen, Pelle Nilsson, Karsten Nysom…

    Citation: BMC Cancer 2017 17:439

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  31. Content type: Case report

    Solitary metastasis of a malignancy to the spleen is rare, particularly for gastric cancer. Only a few case reports have documented isolated splenic metastasis from early gastric cancer. We describe a case of ...

    Authors: Junichi Yoshizawa, Naoki Kubo, Satoshi Ishizone, Fumitoshi Karasawa and Ataru Nakayama

    Citation: BMC Cancer 2017 17:436

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  32. Content type: Research article

    There are two lymphatic flows in lower rectal cancer; one along the inferior mesenteric artery and another towards the internal iliac artery. The benefit of dissection of lateral pelvic (LP) lymph nodes (LPLN)...

    Authors: Shigehiro Yanagita, Yoshikazu Uenosono, Takaaki Arigami, Yoshiaki Kita, Shinichiro Mori and Shoji Natsugoe

    Citation: BMC Cancer 2017 17:433

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  33. Content type: Research article

    Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radio...

    Authors: Ricardo G. Becker, Lauro J. Gregianin, Carlos R. Galia, Reynaldo Jesus-Garcia Filho, Eduardo A. Toller, Gerardo Badell, Suely A. Nakagawa, Alexandre David, André M. Baptista, Eduardo S. Yonamime, Osvaldo A. Serafini, Valter Penna, Julie Francine C. Santos and Algemir L. Brunetto

    Citation: BMC Cancer 2017 17:420

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  34. Content type: Study protocol

    Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders espe...

    Authors: Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-ting Cao, Xin Yang, Jing-Song Han, Yang-feng Wu, Kathleen H. Reilly and Jian-Liu Wang

    Citation: BMC Cancer 2017 17:416

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  35. Content type: Study protocol

    Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. T...

    Authors: Daniel Pfirrmann, Suzan Tug, Oana Brosteanu, Matthias Mehdorn, Martin Busse, Peter P. Grimminger, Florian Lordick, Torben Glatz, Jens Hoeppner, Hauke Lang, Perikles Simon and Ines Gockel

    Citation: BMC Cancer 2017 17:413

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  36. Content type: Research article

    Soft tissue sarcomas are rare entities with over 50 histological subtypes. Liposarcoma (LS) is the most common neoplasm in this group; it is a complex neoplasm that is divided into different histological subty...

    Authors: Carolin Knebel, Ulrich Lenze, Florian Pohlig, Florian Lenze, Norbert Harrasser, Christian Suren, Jonathan Breitenbach, Hans Rechl, Rüdiger von Eisenhart-Rothe and Heinrich M. L. Mühlhofer

    Citation: BMC Cancer 2017 17:410

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  37. Content type: Research article

    Inflammation is widely recognized to play an important role in cancer progression, and the peripheral monocyte count has been reported to correlate with the prognosis in patients with colorectal cancer. This i...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2017 17:404

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  38. Content type: Research article

    The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved lo...

    Authors: Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita and Yoko Nakasu

    Citation: BMC Cancer 2017 17:397

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  39. Content type: Study protocol

    Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal...

    Authors: Christian Kelly-Morland, Sarah Rudman, Paul Nathan, Susan Mallett, Giovanni Montana, Gary Cook and Vicky Goh

    Citation: BMC Cancer 2017 17:392

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  40. Content type: Research article

    To explore the prognostic significance of preoperative prognostic nutritional index (PNI) in bladder cancer after radical cystectomy and compare the prognostic ability of inflammation-based indices.

    Authors: Ding Peng, Yan-qing Gong, Han Hao, Zhi-song He, Xue-song Li, Cui-jian Zhang and Li-qun Zhou

    Citation: BMC Cancer 2017 17:391

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  41. Content type: Research article

    In this study, we aimed to develop an objective staging system to determine the degree of nodal metastasis in breast cancer patients undergoing neoadjuvant systemic treatment (NST).

    Authors: Tae-Kyung Yoo, Jung Min Chang, Hee-Chul Shin, Wonshik Han, Dong-Young Noh and Hyeong-Gon Moon

    Citation: BMC Cancer 2017 17:389

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  42. Content type: Research article

    Increasing evidence indicates that abnormal expression of GABPA is associated with tumor development and progression. However, the function and clinicopathological significance of GABPA in hepatocellular carci...

    Authors: Sheng Zhang, Kang Zhang, Piyou Ji, Xuqing Zheng, Jianbin Jin, Min Feng and Pingguo Liu

    Citation: BMC Cancer 2017 17:380

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  43. Content type: Study protocol

    The role of axillary lymph node dissection (ALND) has increasingly been called into question among patients with positive sentinel lymph nodes. Two recent trials have failed to show a survival difference in se...

    Authors: Jana de Boniface, Jan Frisell, Yvette Andersson, Leif Bergkvist, Johan Ahlgren, Lisa Rydén, Roger Olofsson Bagge, Malin Sund, Hemming Johansson and Dan Lundstedt

    Citation: BMC Cancer 2017 17:379

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