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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 3 of 9

  1. Content type: Research article

    Tumor necrosis (TN) correlates with adverse outcomes in numerous solid tumors. However, its prognostic value in renal cell carcinoma (RCC) remains unclear. In this study, we performed a meta-analysis to evaluate ...

    Authors: Lijin Zhang, Zhenlei Zha, Wei Qu, Hu Zhao, Jun Yuan, Yejun Feng and Bin Wu

    Citation: BMC Cancer 2018 18:870

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  2. Content type: Research article

    The Ki67 Index has been extensively studied as a prognostic biomarker in breast cancer. However, its clinical adoption is largely hampered by the lack of a standardized method to assess Ki67 that limits inter-...

    Authors: Muhammad Khalid Khan Niazi, Caglar Senaras, Michael Pennell, Vidya Arole, Gary Tozbikian and Metin N. Gurcan

    Citation: BMC Cancer 2018 18:867

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  3. Content type: Research article

    Up to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological f...

    Authors: Fan Feng, Jinqiang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian and Hongwei Zhang

    Citation: BMC Cancer 2018 18:865

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  4. Content type: Study protocol

    Despite the fact that the cost-effectiveness of robot-assisted radical cystectomy (RARC) is not yet proven, and open radical (ORC) cystectomy is recommended as the standard of care in patients with high-risk n...

    Authors: C. J. Wijburg, C. T. J. Michels, J. R. Oddens, J. P. C. Grutters, J. A. Witjes and M. M. Rovers

    Citation: BMC Cancer 2018 18:861

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  5. Content type: Study protocol

    Neoadjuvant chemotherapy (NACT) is a standard approach of the multidisciplinary treatment of breast cancer. Depending on the biological subtype a pathological complete response in the breast (bpCR) can be achi...

    Authors: Joerg Heil, Peter Sinn, Hannah Richter, André Pfob, Benedikt Schaefgen, André Hennigs, Fabian Riedel, Bettina Thomas, Marc Thill, Markus Hahn, Jens-Uwe Blohmer, Sherko Kuemmel, Maria Margarete Karsten, Mattea Reinisch, John Hackmann, Toralf Reimer…

    Citation: BMC Cancer 2018 18:851

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  6. Content type: Research article

    Chondrosarcoma is the second most frequent primary malignant bone tumor. Treatment is mainly based on surgery. In general, wide resection is advocated at least in G2 and G3 tumors. But which margins should be ...

    Authors: Julian Fromm, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Christof Birkenmaier, Falk Roeder, Volkmar Jansson and Hans Roland Dürr

    Citation: BMC Cancer 2018 18:849

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  7. Content type: Study protocol

    The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance be...

    Authors: Kayvan Mohkam, Michel Rayar, Jean-Philippe Adam, Fabrice Muscari, Agnès Rode, Philippe Merle, Pierre Pradat, Stéphanie Bauler, Isabelle Delfour, Laurence Chiche, Christian Ducerf, Karim Boudjema, Mickaël Lesurtel, Christophe Laurent and Jean-Yves Mabrut

    Citation: BMC Cancer 2018 18:844

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  8. Content type: Research article

    This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients wit...

    Authors: Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen and Xiao-ping Chen

    Citation: BMC Cancer 2018 18:835

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  9. Content type: Study protocol

    Seroma formation is a common complication after mastectomy and is associated with delayed wound healing, infection, skin flap necrosis, patient discomfort and repeated visits to the out patient clinic to deal ...

    Authors: J. van Bastelaar, R. Granzier, L. M. van Roozendaal, G. Beets, C. D. Dirksen and Y. Vissers

    Citation: BMC Cancer 2018 18:830

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  10. Content type: Research article

    Core needle biopsy (CNB) is a standard diagnostic procedure in the setting of breast cancer screening. However, CNB may result in the borderline diagnoses of lesion of uncertain malignant potential (B3). The a...

    Authors: Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger and Tilman Ehrenstein

    Citation: BMC Cancer 2018 18:829

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  11. Content type: Study protocol

    Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation...

    Authors: Robbert S. Puijk, Alette H. Ruarus, Laurien G. P. H. Vroomen, Aukje A. J. M. van Tilborg, Hester J. Scheffer, Karin Nielsen, Marcus C. de Jong, Jan J. J. de Vries, Babs M. Zonderhuis, Hasan H. Eker, Geert Kazemier, Henk Verheul, Bram B. van der Meijs, Laura van Dam, Natasha Sorgedrager, Veerle M. H. Coupé…

    Citation: BMC Cancer 2018 18:821

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  12. Content type: Research article

    To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC).

    Authors: Linyan Chen, Hao Zeng, Jiapeng Yang, Yuqing Lu, Dan Zhang, Jinggan Wang, Chienyun Kuang, Sha Zhu, Manni Wang and Xuelei Ma

    Citation: BMC Cancer 2018 18:816

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  13. Content type: Case report

    Pilocytic astrocytoma is a low-grade central nervous system tumor most commonly seen in children. Dissemination from a primary intracranial tumor along the neuroaxis has been described at both presentation and...

    Authors: Devin McBride, Zaid Aljuboori, Eyas M. Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat and Eric Burton

    Citation: BMC Cancer 2018 18:806

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  14. Content type: Research article

    Peri-operative inflammation has been extensively highlighted in cancer patients as detrimental. Treatment strategies to improve survival for cancer patients through targeting peri-operative inflammation have y...

    Authors: H. Paul Redmond, Peter M. Neary, Marcel Jinih, Emer O’Connell, Niamh Foley, Rolf W. Pfirrmann, Jiang H. Wang and D. Peter O’Leary

    Citation: BMC Cancer 2018 18:794

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  15. Content type: Study protocol

    After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is ev...

    Authors: Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere and David Malka

    Citation: BMC Cancer 2018 18:787

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  16. Content type: Research article

    As we previously reported, the presence of preoperative metabolic syndrome can predict the significant risk of gastric cancer mortality. As a further extension, we evaluated the prediction of three lipid deriv...

    Authors: Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Guohui Fan, Guodong Xu, Yan Xia, Jinxiu Lin, Xiongwei Zheng and Wenquan Niu

    Citation: BMC Cancer 2018 18:785

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  17. Content type: Research article

    In digital mammography, finding accurate breast profile segmentation of women’s mammogram is considered a challenging task. The existence of the pectoral muscle may mislead the diagnosis of cancer due to its h...

    Authors: Bushra Mughal, Nazeer Muhammad, Muhammad Sharif, Amjad Rehman and Tanzila Saba

    Citation: BMC Cancer 2018 18:778

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  18. Content type: Research article

    18F-FDG PET-CT is commonly used to monitor treatment response in patients with metastatic colorectal cancer (mCRC). With improvement in systemic therapy, complete metabolic response (CMR) is increasingly encou...

    Authors: Keith W. H. Chiu, Ka-On Lam, H. An, Gavin T. C. Cheung, Johnny K. S. Lau, Tim-Shing Choy and Victor H. F. Lee

    Citation: BMC Cancer 2018 18:776

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  19. Content type: Research article

    Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal d...

    Authors: Heesung Hwang, Kwang-Min Lee, Kyung-Lak Son, Dooyoung Jung, Won-Hyoung Kim, Joo-Young Lee, Seong-Ho Kong, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang and Bong-Jin Hahm

    Citation: BMC Cancer 2018 18:765

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  20. Content type: Research article

    Maximum (MIP) and average intensity projection (AIP) CTs allow rapid definition of internal target volumes in a 4D-CT. The purpose of this study was to assess the accuracy of these techniques in a large patien...

    Authors: Kai Joachim Borm, Markus Oechsner, Moritz Wiegandt, Andreas Hofmeister, Stephanie E. Combs and Marciana Nona Duma

    Citation: BMC Cancer 2018 18:760

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  21. Content type: Research article

    This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL).

    Authors: Zhenglei Shen, Xuezhong Gu, Wenwen Mao, Liefen Yin, Ling Yang, Zhe Zhang, Kunmei Liu, Lilan Wang and Yunchao Huang

    Citation: BMC Cancer 2018 18:755

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  22. Content type: Research article

    The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN no...

    Authors: Jianwei Wang, Min Liu, Jingxian Shen, Haichao Ouyang, Xiuying Xie, Ting Lin, Anhua Li and Hong Yang

    Citation: BMC Cancer 2018 18:737

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  23. Content type: Research article

    Bone and soft tissue masses of the foot and ankle are not particularly rare but true neoplasia has to be strictly differentiated from pseudotumorous lesions. Diagnosis is often delayed as diagnostic errors are...

    Authors: Andreas Toepfer, Norbert Harrasser, Maximiliane Recker, Ulrich Lenze, Florian Pohlig, Ludger Gerdesmeyer and Rüdiger von Eisenhart-Rothe

    Citation: BMC Cancer 2018 18:735

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  24. Content type: Research article

    Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metas...

    Authors: Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman and Elin S. Gray

    Citation: BMC Cancer 2018 18:726

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  25. Content type: Research article

    The Union for International Cancer Control (UICC) tumor-node-metastasis (TNM) classification is a key gastric cancer prognosis system. This study aimed to create a new TNM system to provide a reference for the...

    Authors: Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu and Caigang Liu

    Citation: BMC Cancer 2018 18:706

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  26. Content type: Research article

    The prognostic value of preoperative controlling nutritional status (CONUT) has been reported in many malignancies. In present study, we aimed to clarify the prognostic impact of CONUT in gastric cancer (GC) r...

    Authors: Xuechao Liu, Deyao Zhang, Enzi Lin, Yongming Chen, Wei Li, Yingbo Chen, Xiaowei Sun and Zhiwei Zhou

    Citation: BMC Cancer 2018 18:699

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  27. Content type: Research article

    Emerging inflammatory response biomarkers are developed to predict the survival of patients with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive ...

    Authors: Ying Wang, Xiao Qu, Ngar-Woon Kam, Kai Wang, Hongchang Shen, Qi Liu and Jiajun Du

    Citation: BMC Cancer 2018 18:692

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  28. Content type: Research article

    High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity of the disease, the clinical outcomes, prognosti...

    Authors: Jeon Yeob Jang, Nayeon Choi, Young-Hyeh Ko, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek, Kwan-Hyuck Baek and Han-Sin Jeong

    Citation: BMC Cancer 2018 18:672

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  29. Content type: Research article

    Laparoscopic liver resection has been reported as a safe and effective approach for the management of hepatocellular carcinoma (HCC). However, its perioperative and oncological outcomes have not been evaluated...

    Authors: Jong Man Kim, Choon Hyuck David Kwon, Heejin Yoo, Kyeung-Sik Kim, Jisoo Lee, Kyunga Kim, Gyu-Seong Choi and Jae-Won Joh

    Citation: BMC Cancer 2018 18:668

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  30. Content type: Research article

    This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment by CalliSpheres® in Chinese patients with hepatocellular carcinoma (HCC) as we...

    Authors: Guan-Hui Zhou, Jun Han, Jun-Hui Sun, Yue-Lin Zhang, Tan-Yang Zhou, Chun-Hui Nie, Tong-Yin Zhu, Sheng-Qun Chen, Bao-Quan Wang, Zi-Niu Yu, Hong-Liang Wang, Li-Ming Chen, Wei-Lin Wang and Shu-Sen Zheng

    Citation: BMC Cancer 2018 18:644

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  31. Content type: Research article

    The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes ...

    Authors: Chong Zhong, Yong-Fa Zhang, Jun-Hai Huang, Cheng-Ming Xiong, Zi-Yu Wang, Qing-Lian Chen and Rong-Ping Guo

    Citation: BMC Cancer 2018 18:643

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  33. Content type: Research article

    The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aime...

    Authors: Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng

    Citation: BMC Cancer 2018 18:563

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  34. Content type: Research article

    The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right colon cancer and left colon cancer have different characteristics, and this threshold value fo...

    Authors: Lin Yang, Zhenchong Xiong, Qiankun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Guifang Guo and Liangping Xia

    Citation: BMC Cancer 2018 18:558

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  35. Content type: Research article

    Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction ...

    Authors: Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras and Kuno Lehmann

    Citation: BMC Cancer 2018 18:548

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  36. Content type: Research article

    Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous r...

    Authors: Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong and Young Deuk Choi

    Citation: BMC Cancer 2018 18:545

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  37. Content type: Research article

    Malnutrition and weight loss are commonly observed in patients with pancreatic cancer and contribute to poor survival. Pancreatic exocrine insufficiency (PEI), which can be caused by ductal obstruction by a tu...

    Authors: Juan Enrique Domínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader and Julio Iglesias-Garcia

    Citation: BMC Cancer 2018 18:534

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  38. Content type: Research article

    Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpecte...

    Authors: Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni and Cosimo Sperti

    Citation: BMC Cancer 2018 18:531

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  39. Content type: Research article

    Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer. The prognosis of women with NECC is poor and there is no standardized therapy for this type of malignancy based on controlled...

    Authors: Clemens B. Tempfer, Iris Tischoff, Askin Dogan, Ziad Hilal, Beate Schultheis, Peter Kern and Günther A. Rezniczek

    Citation: BMC Cancer 2018 18:530

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  40. Content type: Case report

    Glomus tumor is a rare benign neoplasm, which most frequently occurs in the subungual regions of digits. Tumor rupture and infection occurred in one patient with a glomus tumor have never been reported.

    Authors: Hui Lu, Li Feng Chen and Qiang Chen

    Citation: BMC Cancer 2018 18:505

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  41. Content type: Case report

    Ewing’s sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing’s sarcoma at the distal end of the tibia....

    Authors: Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka and Toshikazu Kubo

    Citation: BMC Cancer 2018 18:503

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  42. Content type: Case report

    Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa h...

    Authors: Samiullah Khan, Lan-ping Zhu, Yujie Zhang, Xin Chen and Bang-mao Wang

    Citation: BMC Cancer 2018 18:502

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  43. Content type: Research article

    There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS),...

    Authors: Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida and Takao Kamai

    Citation: BMC Cancer 2018 18:493

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  44. Content type: Research article

    Intravenous chemotherapy (IVC) and intra-arterial chemotherapy (IAC) have become the primary treatments for retinoblastoma; however, some controversy remains over which method is more effective. We conducted a...

    Authors: Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Wenhui Huang, Hua Jiang, Jiejun Xia and Shuixing Zhang

    Citation: BMC Cancer 2018 18:486

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  45. Content type: Case report

    Calcification in primary gastric cancer is very rare. In this report, we describe the computerized tomography (CT) changes in calcification in a patient with locally advanced signet-ring gastric cancer treated...

    Authors: Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang and Long Huang

    Citation: BMC Cancer 2018 18:474

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  46. Content type: Research article

    Clinical trial (CT) participation may confer access to new, potentially active agents before their general availability. This study aimed to investigate the potential survival benefit of participation in inves...

    Authors: Kyo Chul Koo, Jong Soo Lee, Jong Won Kim, Kyung Suk Han, Kwang Suk Lee, Do Kyung Kim, Yoon Soo Ha, Koon Ho Rha, Sung Joon Hong and Byung Ha Chung

    Citation: BMC Cancer 2018 18:468

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  47. Content type: Research article

    The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primari...

    Authors: Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin and Zhenyu Zhang

    Citation: BMC Cancer 2018 18:461

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  48. Content type: Research article

    Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signali...

    Authors: Fei Ji, Zhi-heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang and Yun-Peng Hua

    Citation: BMC Cancer 2018 18:460

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  49. Content type: Study protocol

    Cosmetic result in breast cancer surgery is gaining increased interest. Currently, some 30–40% of the patients treated with breast conserving surgery (BCS) are dissatisfied with their final cosmetic result. In...

    Authors: Coriene J. L. M. Catsman, Martinus A. Beek, Adri C. Voogd, Paul G. H. Mulder and Ernest J. T. Luiten

    Citation: BMC Cancer 2018 18:456

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  50. Content type: Study protocol

    Initial staging of gastric cancer consists of computed tomography (CT) and gastroscopy. In locally advanced (cT3–4) gastric cancer, fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT or PET) a...

    Authors: H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det…

    Citation: BMC Cancer 2018 18:450

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