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BMC Cancer

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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

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  1. Content type: Study protocol

    In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Authors: Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh

    Citation: BMC Cancer 2017 17:649

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  2. Content type: Research article

    Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear.

    Authors: Fei-Xiang Wu, Jie Chen, Tao Bai, Shao-Liang Zhu, Tian-Bo Yang, Lu-Nan Qi, Ling Zou, Zi-Hui Li, Jia-Zhou Ye and Le-Qun Li

    Citation: BMC Cancer 2017 17:645

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  3. Content type: Case report

    A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We ...

    Authors: Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely and Hajnalka Vago

    Citation: BMC Cancer 2017 17:612

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  4. Content type: Research article

    Larynx preservation (LP) is recommended for up to low-volume T4 laryngeal cancer as an evidence-based treatment option that does not compromise survival. However, a reevaluation of the current literature raise...

    Authors: Gerhard Dyckhoff, Peter K. Plinkert and Heribert Ramroth

    Citation: BMC Cancer 2017 17:609

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  5. Content type: Case report

    The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response ra...

    Authors: Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens and Philippe G. Jorens

    Citation: BMC Cancer 2017 17:586

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  6. Content type: Research article

    Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked to tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of r...

    Authors: Myung-Giun Noh, Se-Jeong Oh, Eun-Jung Ahn, Yeong-Jin Kim, Tae-Young Jung, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Kyung-Hwa Lee and Kyung-Sub Moon

    Citation: BMC Cancer 2017 17:583

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  7. Content type: Research article

    The Cancer Genome Atlas Research Network reported that high-grade serous carcinoma (HGSC) can be classified based on gene expression profiles into four subtypes, termed “immunoreactive,” “differentiated,” “pro...

    Authors: Takuma Ohsuga, Ken Yamaguchi, Aki Kido, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondoh, Tsukasa Baba, Ikuo Konishi and Noriomi Matsumura

    Citation: BMC Cancer 2017 17:580

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  8. Content type: Case report

    Neurofibromatosis type 1 is a relatively common inherited disorder. Patients with neurofibromatosis type 1 are at high risk of developing neurogenic, neuroendocrine and mesenchymal intra-abdominal tumors. Alth...

    Authors: Nihed Abdessayed, Rahul Gupta, Sarra Mestiri, Ahlem Bdioui, Mounir Trimech and Moncef Mokni

    Citation: BMC Cancer 2017 17:579

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  9. Content type: Research article

    Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF)...

    Authors: Anders Christensen, Katalin Kiss, Giedrius Lelkaitis, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Julie Lyng Forman, Anne Lyngholm Sørensen, David Hebbelstrup Jensen, Andreas Kjaer and Christian von Buchwald

    Citation: BMC Cancer 2017 17:572

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  10. Content type: Research article

    The relationship between the number of harvested lymph nodes (HLNs) and prognosis of gastric cancer patients without an involvement of lymph nodes has not been well-evaluated. The objective of this study is to...

    Authors: Xin Ji, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia and Jia-Fu Ji

    Citation: BMC Cancer 2017 17:558

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  11. Content type: Study protocol

    Following esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of esop...

    Authors: Jonna K. van Vulpen, Peter D. Siersema, Richard van Hillegersberg, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Eric J. Hazebroek, Camiel Rosman, Carlo C. G. Schippers, Elles Steenhagen, Petra H. M. Peeters and Anne M. May

    Citation: BMC Cancer 2017 17:552

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  12. Content type: Research article

    The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor...

    Authors: Gang Li, Jianpeng Yu, Hualin Song, Shimiao Zhu, Libin Sun, Zhiqun Shang and Yuanjie Niu

    Citation: BMC Cancer 2017 17:530

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  13. Content type: Research article

    Solid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we repor...

    Authors: Lina Zhang, Ling Zhuang, Chang Shi, Yanwei Miao, Weisheng Zhang, Qingwei Song, Jianyun Kang, Zhijin Lang, Xuegang Xin, Ailian Liu and Jiani Hu

    Citation: BMC Cancer 2017 17:525

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  14. Content type: Research article

    Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can b...

    Authors: Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht and Ulrich Steger

    Citation: BMC Cancer 2017 17:522

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  15. Content type: Research article

    Although several studies have been conducted on the role of surgery in localized neuroblastoma, the impact of surgical timing and extent of primary tumor resection on outcome in high-risk patients remains cont...

    Authors: Janina Fischer, Alexandra Pohl, Ruth Volland, Barbara Hero, Martin Dübbers, Grigore Cernaianu, Frank Berthold, Dietrich von Schweinitz and Thorsten Simon

    Citation: BMC Cancer 2017 17:520

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  16. Content type: Research article

    To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cerv...

    Authors: Jing Li, Ni-ya Ning, Qun-xian Rao, Rong Chen, Li-juan Wang and Zhong-qiu Lin

    Citation: BMC Cancer 2017 17:517

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  17. Content type: Study protocol

    Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for C...

    Authors: Matthew H. G. Katz, Fang-Shu Ou, Joseph M. Herman, Syed A. Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H. Schwartz, Wendy Frankel, Eric Collisson, Eugene J. Koay, JoLeen M. Hubbard, James L. Leenstra, Jeffrey Meyerhardt…

    Citation: BMC Cancer 2017 17:505

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  18. Content type: Case report

    Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on ...

    Authors: Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma. Reyes Oliver-Perez and Jesús S. Jiménez-López

    Citation: BMC Cancer 2017 17:503

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