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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 2 of 7

  1. Content type: Research article

    The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of...

    Authors: Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin and Shengping Li

    Citation: BMC Cancer 2018 18:327

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  2. Content type: Research article

    The incidence of colorectal cancer in adolescent and young adult patients is increasing. However, survival and clinical features of young patients, especially those with stage IV disease, relative to adult pat...

    Authors: Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku and Yukihide Kanemitsu

    Citation: BMC Cancer 2018 18:334

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  3. Content type: Case report

    Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targ...

    Authors: Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan and Lu Pan

    Citation: BMC Cancer 2018 18:338

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  4. Content type: Research article

    Age is an important prognostic factor in papillary thyroid cancer (PTC), with better survival observed in patients < 45 years of age, regardless of stage. Although the impact of increasing age on PTC-related s...

    Authors: Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte and John H. Yim

    Citation: BMC Cancer 2018 18:316

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  5. Content type: Research article

    Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognos...

    Authors: Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu and Jiejie Xu

    Citation: BMC Cancer 2018 18:313

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  6. Content type: Research article

    Liposarcomas are the second most common type of soft tissue sarcomas, 30–50% of these are of myxoid subtype. The aim of this retrospective study was to analyze the local control rate, the metastatic pattern an...

    Authors: Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson and Alexander Klein

    Citation: BMC Cancer 2018 18:304

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  7. Content type: Case report

    Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse pr...

    Authors: Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani and Satoshi Ito

    Citation: BMC Cancer 2018 18:300

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  8. Content type: Case report

    Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare.

    Authors: Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone and Maria Abbondanza Pantaleo

    Citation: BMC Cancer 2018 18:301

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  9. Content type: Research article

    The nomogram of the Barcelona Clinic Liver Cancer (BCLC) for hepatocellular carcinoma (HCC) has been used for outcome prediction. Patients with BCLC stage C HCC often undergo anti-cancer therapy against curren...

    Authors: Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang and Teh-Ia Huo

    Citation: BMC Cancer 2018 18:289

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  10. Content type: Research article

    An ideal tumor marker should be capable of being detected at any stage of the disease. However, gastric cancer patients do not always have elevated serum carcinoembryonic antigen (CEA) levels, even in advanced...

    Authors: Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura and Yasunari Kawabata

    Citation: BMC Cancer 2018 18:285

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  11. Content type: Research article

    Cancer surgery can promote tumour metastases and worsen prognosis, however, the effect of perioperative complications on metastatic disease remains unclear. In this study we sought to evaluate the effect of co...

    Authors: Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy and Rebecca C. Auer

    Citation: BMC Cancer 2018 18:277

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    The Correction to this article has been published in BMC Cancer 2018 18:437

  12. Content type: Research article

    Microvascular invasion (MVI) is well established as a negative prognostic factor for hepatocelluar carcinoma (HCC). However, its prognostic value in different subgroups of Barcelona Clinical Liver Cancer (BCLC...

    Authors: Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang and Changli Lu

    Citation: BMC Cancer 2018 18:278

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  13. Content type: Case report

    After orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), recurrent HCC mostly develops within 2 years. All cases of de novo HCC described so far occurred later than 2 years after OLT. Prev...

    Authors: Giuliano Ramadori, Patrizia Bosio, Federico Moriconi and Ihtzaz A. Malik

    Citation: BMC Cancer 2018 18:257

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  14. Content type: Research article

    This study aimed to investigate the safety of sorafenib for the treatment of unresectable hepatocellular carcinoma in Chinese patients.

    Authors: Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu…

    Citation: BMC Cancer 2018 18:247

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  15. Content type: Research article

    The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM). Using pre-operative MRI techniques to predict MGMT promo...

    Authors: Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang…

    Citation: BMC Cancer 2018 18:215

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  16. Content type: Research article

    There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatoc...

    Authors: Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang and Ming-qing Xu

    Citation: BMC Cancer 2018 18:216

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  17. Content type: Research article

    Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ult...

    Authors: Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown and M. J. Kerin

    Citation: BMC Cancer 2018 18:203

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    The Correction to this article has been published in BMC Cancer 2018 18:282

  18. Content type: Study protocol

    Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6...

    Authors: A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo…

    Citation: BMC Cancer 2018 18:183

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  19. Content type: Study protocol

    While the incidence of esophageal and gastric cancers is increasing, the prognosis of these cancers remains bleak. Endoscopy and surgery are the standard treatments for localized tumors, but multimodal treatme...

    Authors: Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe and Antoine Adenis

    Citation: BMC Cancer 2018 18:139

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  20. Content type: Study protocol

    Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection ...

    Authors: Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef…

    Citation: BMC Cancer 2018 18:142

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  21. Content type: Research article

    The association between body mass index (BMI) and clinical outcomes of gastric cancer were still under debate. The aim of the present study was to investigate the impact of BMI on intraoperative conditions, po...

    Authors: Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian and Hongwei Zhang

    Citation: BMC Cancer 2018 18:151

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  22. Content type: Case report

    Extra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours’ histological c...

    Authors: Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli and Giovanni Battista La Sala

    Citation: BMC Cancer 2018 18:134

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  23. Content type: Research article

    Despite the recent changes in the treatment of the axilla in selected breast cancer patient, positive sentinel lymph node (SLN) in patients undergoing mastectomy still necessitates axillary lymph node dissecti...

    Authors: Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic and Andrej Vogrin

    Citation: BMC Cancer 2018 18:137

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  24. Content type: Research article

    Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high inc...

    Authors: Keiji Nishibeppu, Shuhei Komatsu, Daisuke Ichikawa, Taisuke Imamura, Toshiyuki Kosuga, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara and Eigo Otsuji

    Citation: BMC Cancer 2018 18:108

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  25. Content type: Research article

    Women with a personal history of breast cancer are at increased risk of future breast cancer events, and may benefit from supplemental screening methods that could enhance early detection of subclinical diseas...

    Authors: Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon and Jung Hyun Yoon

    Citation: BMC Cancer 2018 18:91

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  26. Content type: Research article

    Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided li...

    Authors: Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas and Jacob Freedman

    Citation: BMC Cancer 2018 18:78

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  27. Content type: Research article

    The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical...

    Authors: S. Mokhles, J. J. M. E. Nuyttens, M. de Mol, J. G. J. V. Aerts, A. P. W. M. Maat, Ö. Birim, A. J. J. C. Bogers and J. J. M. Takkenberg

    Citation: BMC Cancer 2018 18:79

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  28. Content type: Research article

    Greater lymph node retrieval in gastric cancer improves staging accuracy and may improve survival from increased clearance of nodal micrometastasis. This retrospective cohort study investigated if more lymph n...

    Authors: Shiela S. Macalindong, Kwang Hee Kim, Byung-Ho Nam, Keun Won Ryu, Norihito Kubo, Ja Yeon Kim, Bang Wool Eom, Hong Man Yoon, Myeong-Cherl Kook, Il Ju Choi and Young Woo Kim

    Citation: BMC Cancer 2018 18:73

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  29. Content type: Research article

    To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rat...

    Authors: Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan and Kefeng Ding

    Citation: BMC Cancer 2018 18:50

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  30. Content type: Research article

    Surgical resection is necessary to conduct a pathological biopsy and to achieve a reduction of intracranial pressure in low-grade gliomas patients. This study aimed to determine whether a greater extent of res...

    Authors: Liang Xia, Chenyan Fang, Gao Chen and Caixing Sun

    Citation: BMC Cancer 2018 18:48

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  31. Content type: Case report

    Although cases of multiple primary malignant neoplasms are increasing, reports of more than three or four primary metachronous malignant neoplasms are extremely rare. Moreover, very few publications have provi...

    Authors: Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama and Toshiaki Watanabe

    Citation: BMC Cancer 2018 18:24

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  32. Content type: Case report

    Extra-abdominal metastases in low grade endometrial carcinoma are rare events. Inguinal lymphatic spread occurs usually in advanced disease and is associated with abdominal lymph nodes involvement. To our know...

    Authors: Anna Myriam Perrone, Giulia Girolimetti, Simona Cima, Ivana Kurelac, Alessandra Livi, Giacomo Caprara, Donatella Santini, Paolo Castellucci, Alessio Giuseppe Morganti, Giuseppe Gasparre and Pierandrea De Iaco

    Citation: BMC Cancer 2018 18:7

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  33. Content type: Research article

    The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer.

    Authors: Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim and Young-Hoon Joo

    Citation: BMC Cancer 2017 17:904

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  34. Content type: Research article

    TP53 is the most frequently mutated gene in human cancers. Previous studies reported that TP53 mutations correlated with poor prognoses in patients with head and neck squamous cell car...

    Authors: Go Omura, Mizuo Ando, Yasuhiro Ebihara, Yuki Saito, Kenya Kobayashi, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Takahiro Asakage and Tatsuya Yamasoba

    Citation: BMC Cancer 2017 17:898

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  35. Content type: Research article

    No consensus treatment has been reached for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Hepatic resection (HR) and transarterial chemoembolization (TACE) have been recommended as eff...

    Authors: Xiu-Ping Zhang, Kang Wang, Nan Li, Cheng-Qian Zhong, Xu-Biao Wei, Yu-Qiang Cheng, Yu-Zhen Gao, Han Wang and Shu-Qun Cheng

    Citation: BMC Cancer 2017 17:902

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  36. Content type: Research article

    This study provides a comprehensive examination of the histological features of non-neoplastic parenchyma in renal cell carcinoma (RCC). We prospectively collected radical nephrectomy (RN) specimens, to analyz...

    Authors: Xun Wang, Qiang Liu, Wen Kong, Jiwei Huang, Yonghui Chen, Yiran Huang and Jin Zhang

    Citation: BMC Cancer 2017 17:900

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  37. Content type: Research article

    The aim of this study was to evaluate the value of 18F–FDG PET/CT (PET/CT) and MRI for local and/or whole-body restaging of adenoid cystic carcinoma of the head and neck (ACC).

    Authors: Verena Ruhlmann, Thorsten D. Poeppel, Johannes Veit, James Nagarajah, Lale Umutlu, Thomas K. Hoffmann, Andreas Bockisch, Ken Herrmann and Wolfgang Sauerwein

    Citation: BMC Cancer 2017 17:887

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  38. Content type: Case report

    Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and...

    Authors: Yuntong Ma, Bingqi Shen, Yingmei Jia, Yanji Luo, Yisu Tian, Zhi Dong, Wei Chen, Zi-Ping Li and Shi-Ting Feng

    Citation: BMC Cancer 2017 17:853

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  39. Content type: Research article

    Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous researc...

    Authors: G. David Baxter, Lizhou Liu, Simone Petrich, Angela Spontelli Gisselman, Cathy Chapple, Juanita J. Anders and Steve Tumilty

    Citation: BMC Cancer 2017 17:833

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  40. Content type: Research article

    Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 i...

    Authors: Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui and Yi Jin

    Citation: BMC Cancer 2017 17:828

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  41. Content type: Research article

    18F–fluoro-deoxyglucose positron emission tomography with computed tomography (FDG PET/CT) has been employed to define radiotherapy targets using a threshold based on the standardised ...

    Authors: Alta Y. T. Lai, Jose A. U. Perucho, Xiaopei Xu, Edward S. Hui and Elaine Y. P. Lee

    Citation: BMC Cancer 2017 17:825

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  42. Content type: Research article

    Serum C-reactive protein (CRP) level can be an indicator of the early stage of infectious complications. However, its utility in advanced esophageal cancer patients who receive radical esophagectomy with two- ...

    Authors: Kazuki Kano, Toru Aoyama, Tetsushi Nakajima, Yukio Maezawa, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Haruhiko Cho, Takaki Yoshikawa and Takashi Ogata

    Citation: BMC Cancer 2017 17:812

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  43. Content type: Research article

    Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognosti...

    Authors: Xiaoyu Ji, Yingjie Zhuang, Xiangye Yin, Qiong Zhan, Xinli Zhou and Xiaohua Liang

    Citation: BMC Cancer 2017 17:774

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  44. Content type: Research article

    Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for thi...

    Authors: Baki Topal, Karel Demey, Halit Topal, Joris Jaekers, Eric Van Cutsem, Vincent Vandecaveye, Xavier Sagaert and Hans Prenen

    Citation: BMC Cancer 2017 17:771

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  45. Content type: Research article

    The worldwide incidence of neuroendocrine tumors (NETs) has increased remarkably, with the hindgut being the second most common site for such tumors. However, the mechanisms underlying progression and metastas...

    Authors: Yoichiro Okubo, Rika Kasajima, Masaki Suzuki, Yohei Miyagi, Osamu Motohashi, Manabu Shiozawa, Emi Yoshioka, Kota Washimi, Kae Kawachi, Yoichi Kameda and Tomoyuki Yokose

    Citation: BMC Cancer 2017 17:769

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  46. Content type: Research article

    Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy. The aim of t...

    Authors: Dai Shida, Gen Iinuma, Akira Komono, Hiroki Ochiai, Shunsuke Tsukamoto, Mototaka Miyake and Yukihide Kanemitsu

    Citation: BMC Cancer 2017 17:764

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