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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 8

  1. Content type: Research article

    More colon cancer patients are expected to fully recover after treatment due to earlier detection of cancer and improvements in general health- and cancer care. The objective of this study was to gather partic...

    Authors: C. M. den Bakker, F. G. Schaafsma, J. A. F. Huirne, E. C. J. Consten, H. B. A. C. Stockmann, C. J. Rodenburg, G. J. de Klerk, H. J. Bonjer and J. R. Anema

    Citation: BMC Cancer 2018 18:1207

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  2. Content type: Research article

    Prostate biopsy is the most common method for the diagnosis of prostate cancer and the basis for further treatment. Confirmation using radical prostatectomy specimens is the most reliable method for verifying ...

    Authors: Zhipeng Mai, Zhien Zhou, Weigang Yan, Yu Xiao, Yi Zhou, Zhiyong Liang, Zhigang Ji and Hanzhong Li

    Citation: BMC Cancer 2018 18:1205

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  3. Content type: Research article

    The incidence of colorectal cancer (CRC) is expected to increase by 80% in year 2035. Even though advantages in treatment of CRC have being made over the last decades, the outcome remains poor. Recently, sever...

    Authors: Nikoletta Dimitriou, Evangelos Felekouras, Ioannis Karavokyros, Andreas Alexandrou, Emmanuel Pikoulis and John Griniatsos

    Citation: BMC Cancer 2018 18:1202

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  4. Content type: Research article

    Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([18F] FDG) a...

    Authors: María Collantes, Naiara Martínez-Vélez, Marta Zalacain, Lucia Marrodán, Margarita Ecay, María José García-Velloso, Marta María Alonso, Ana Patiño-García and Iván Peñuelas

    Citation: BMC Cancer 2018 18:1193

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  5. Content type: Research article

    To investigate whether PET/CT-guided bone marrow biopsy adds complementary information for evaluation of bone marrow involvement (BMI) in newly diagnosed lymphomas.

    Authors: Bing Hao, Long Zhao, Na-na Luo, Dan Ruan, Yi-zhen Pang, Wei Guo, Hao Fu, Xiu-yu Guo, Zuo-ming Luo, Jing Wu, Hao-jun Chen, Hua Wu and Long Sun

    Citation: BMC Cancer 2018 18:1192

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  6. Content type: Research article

    The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences.

    Authors: Hao Yao, Bo Wang, Lili Wen, Qinglin Jin, Hongbo Li, Gang Huang, Junqiang Yin, Changye Zou, Xianbiao Xie and Jingnan Shen

    Citation: BMC Cancer 2018 18:1195

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  7. Content type: Research article

    Malignant bowel obstruction (MBO) is often a terminal event in end-stage cancer patients. The decision to intervene surgically is complex, given the risk of harm in patients with a limited lifespan. Therefore,...

    Authors: Sarah B. Bateni, Alicia A. Gingrich, Susan L. Stewart, Frederick J. Meyers, Richard J. Bold and Robert J. Canter

    Citation: BMC Cancer 2018 18:1166

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  8. Content type: Research article

    Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed t...

    Authors: In Ok Lee, Jung-Yun Lee, Hyun Jeong Kim, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Chang Young Lee, Won Jun Kang and Young Tae Kim

    Citation: BMC Cancer 2018 18:1165

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  9. Content type: Research article

    Because of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to esta...

    Authors: Shuang-zheng Jia, Jun-ji Zhang, Zhi-yong Liang, Jun-jun Yang, Yang Xiang, Cong-wei Jia and Jin-hua Leng

    Citation: BMC Cancer 2018 18:1160

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  10. Content type: Research article

    Fertility sparing surgery has been extensively performed among patients with borderline ovarian tumors due to their age and favorable prognosis. Nevertheless, the prognosis and obstetric outcomes in these pati...

    Authors: Chenyan Fang, Lingqin Zhao, Xi Chen, Aijun Yu, Liang Xia and Ping Zhang

    Citation: BMC Cancer 2018 18:1147

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  11. Content type: Research article

    Radiomics is an emerging field in oncological research. In this study, we aimed at developing a radiomics score (rad-score) to estimate postoperative recurrence and survival in patients with solitary hepatocel...

    Authors: Bo-Hao Zheng, Long-Zi Liu, Zhi-Zhi Zhang, Jie-Yi Shi, Liang-Qing Dong, Ling-Yu Tian, Zhen-bin Ding, Yuan Ji, Sheng-Xiang Rao, Jian Zhou, Jia Fan, Xiao-Ying Wang and Qiang Gao

    Citation: BMC Cancer 2018 18:1148

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  12. Content type: Research article

    Three randomized trials have concluded at non inferiority of omission of complementary axillary lymph node dissection (cALND) for patients with involved sentinel node (SN). However, we can outline strong limit...

    Authors: Gilles Houvenaeghel, Monique Cohen, Pédro Raro, Jérémy De Troyer, Christine Tunon de Lara, Pierre Gimbergues, Tristan Gauthier, Christelle Faure-Virelizier, Véronique Vaini-Cowen, Stéphane Lantheaume, Claudia Regis, Emile Darai, Vivien Ceccato, Gauthier D’Halluin, Francesco Del Piano, Richard Villet…

    Citation: BMC Cancer 2018 18:1153

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  13. Content type: Research article

    The lymphocyte-to-monocyte ratio (LMR) has been used as a parameter reflecting systemic inflammation in several tumors, and is reportedly associated with prognosis in cancer patients. In this study, we evaluat...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2018 18:1137

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  14. Content type: Research article

    Hepatocellular carcinoma (HCC) is a common cancer worldwide, with a poor prognosis. Most patients are diagnosed at advanced stages and are only eligible for palliative therapy. Therefore, this study aimed to e...

    Authors: Shiguang Chen, Wenchang Yu, Kongzhi Zhang and Weifu Liu

    Citation: BMC Cancer 2018 18:1131

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  15. Content type: Study protocol

    Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing. Surgery is the e...

    Authors: Ziyu Li, Fei Shan, Xiangji Ying, Kan Xue and Jiafu Ji

    Citation: BMC Cancer 2018 18:1118

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  16. Content type: Research article

    With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following c...

    Authors: Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha and Sung Hoon Noh

    Citation: BMC Cancer 2018 18:1116

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  17. Content type: Case report

    Sacral chordoma is a locally aggressive malignant tumour originating from ectopic notochordal cells. The natural history of sacral chordoma is a slow growing tumour arising at the midline of the lower sacrum t...

    Authors: Zi Hao Phang, Xue Yi Saw, Noreen Fadzlina Binti Mat Nor, Zolqarnain Bin Ahmad and Sa’adon Bin Ibrahim

    Citation: BMC Cancer 2018 18:1112

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  18. Content type: Research article

    This study aims to establish a radiomics analysis system for the diagnosis and clinical behaviour prediction of hepatocellular carcinoma (HCC) based on multi-parametric ultrasound imaging.

    Authors: Zhao Yao, Yi Dong, Guoqing Wu, Qi Zhang, Daohui Yang, Jin-Hua Yu and Wen-Ping Wang

    Citation: BMC Cancer 2018 18:1089

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  19. Content type: Research article

    In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression wa...

    Authors: Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Monika Bauden, Yi Jiang and Roland Andersson

    Citation: BMC Cancer 2018 18:1096

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  20. Content type: Research article

    The objective of our study was to evaluate the clinical significance of invisible prostate cancer (iPCa) on multiparametric magnetic resonance imaging (mpMRI) by analyzing clinical parameters and oncologic out...

    Authors: Doo Yong Chung, Dong Hoon Koh, Hyeok Jun Goh, Min Seok Kim, Jong Soo Lee, Won Sik Jang and Young Deuk Choi

    Citation: BMC Cancer 2018 18:1057

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  21. Content type: Research article

    Psychiatric patients with colorectal cancer may have delayed diagnosis and be oncologically undertreated.

    Authors: Linda Kaerlev, Maria Iachina, Oleg Trosko, Niels Qvist, Pernille Møller Ljungdalh and Bente Mertz Nørgård

    Citation: BMC Cancer 2018 18:1050

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  22. Content type: Research article

    The oncologic safety of allogeneic blood transfusion in ovarian cancer patients is unknow. We sought to determine the prevalence and oncologic safety of perioperative allogeneic blood transfusion during interv...

    Authors: Kevin W McCool, Emmanuel Sampene, Brock Polnaszek, Joseph Connor, Erin E Medlin and Lisa Barroilhet

    Citation: BMC Cancer 2018 18:1041

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  23. Content type: Case report

    Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimen...

    Authors: Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hiroyuki Inatani, Yu Aoki, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki and Hiroyuki Tsuchiya

    Citation: BMC Cancer 2018 18:1036

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  24. Content type: Research article

    Pancreatic cancer is a highly malignant tumor with a poor prognosis. Chemotherapy such as gemcitabine is still an important treatment. Gemcitabine (Gem) may prolong survival time and delay the development of r...

    Authors: Hua Chen, Ruizhi He, Xiuhui Shi, Min Zhou, Chunle Zhao, Hang Zhang and Renyi Qin

    Citation: BMC Cancer 2018 18:1034

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  25. Content type: Research article

    Cavity occurs in 5.7 to 14.9% of patients with lung adenocarcinoma (ADC). However, the impact of cavity on the therapeutic response to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in...

    Authors: Fei Zhou, Wanrong Ma, Wei Li, Huijuan Ni, Guanghui Gao, Xiaoxia Chen, Jie Zhang and Jingyun Shi

    Citation: BMC Cancer 2018 18:1033

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  26. Content type: Research article

    Peripheral monocyte count is an assessable parameter. Recently, evidence suggested an elevated preoperative monocyte counts predicting poor prognosis in malignancies. The aim of this study was to determine the...

    Authors: Yang Hai, Nan Chen, Wenwen Wu, Zihuai Wang, Feng Lin, Chenglin Guo, Chengwu Liu, Weimin Li and Lunxu Liu

    Citation: BMC Cancer 2018 18:1011

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  27. Content type: Research article

    To assess the prognostic factors and investigate the optimal treatment of gastric mixed adenoneuroendocrine tumors.

    Authors: Jian-Wei Xie, Jun Lu, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chao-Hui Zheng, Ping Li and Chang-Ming Huang

    Citation: BMC Cancer 2018 18:1021

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  28. Content type: Study protocol

    Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluat...

    Authors: A. S. Borggreve, S. Mook, M. Verheij, V. E. M. Mul, J. J. Bergman, A. Bartels-Rutten, L. C. ter Beek, R. G. H. Beets-Tan, R. J. Bennink, M. I. van Berge Henegouwen, L. A. A. Brosens, I. L. Defize, J. M. van Dieren, H. Dijkstra, R. van Hillegersberg, M. C. Hulshof…

    Citation: BMC Cancer 2018 18:1006

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  29. Content type: Research article

    The evaluation of cervical lymph nodes is very important for patients with papillary thyroid carcinoma (PTC). Conventional ultrasound is recommended to assess the status of cervical lymph nodes but the diagnos...

    Authors: Wanying Chang, Lei Tang, Caiwei Lu, Min Wu and Man Chen

    Citation: BMC Cancer 2018 18:1001

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  30. Content type: Case report

    The incidence of ocular metastasis from lung cancer is reported to be 0.1–7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involve...

    Authors: Ye Guo, Xu Wang, Jun Xiao, Yinghui Xu, Yangyang Cai, Chao Sun and Kewei Ma

    Citation: BMC Cancer 2018 18:1004

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  31. Content type: Case report

    Sarcomas that arise from the scapula or periscapular soft tissues often require a total scapulectomy. This often implies a large complex tissue defect that needs adequate reconstruction of both bone and soft t...

    Authors: Giovanni Beltrami, Gabriele Ristori, Guido Scoccianti, Angela Tamburini, Rodolfo Capanna, Domenico Campanacci and Marco Innocenti

    Citation: BMC Cancer 2018 18:1003

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  32. Content type: Research article

    The number of patients requesting autologous breast reconstruction (ABR) after mastectomy for breast cancer has increased over the past decades. However, concern has been expressed about the oncological safety...

    Authors: Joachim Geers, Hans Wildiers, Katrien Van Calster, Annouschka Laenen, Giuseppe Floris, Marc Vandevoort, Gerd Fabre, Ines Nevelsteen and Ann Smeets

    Citation: BMC Cancer 2018 18:994

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  33. Content type: Research article

    The impact of tumor size on prognosis for surgically treated patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. A systematic review and meta-analysis was performed to evaluate this is...

    Authors: Debang Li, Bin Hu, Yanming Zhou, Tao Wan and Xiaoying Si

    Citation: BMC Cancer 2018 18:985

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  34. Content type: Case report

    Sarcomas account for less than 1% of primary breast cancers, and breast angiosarcomas are responsible for only 0.05% of all breast malignancies. The male breast has the same potential for malignant transformat...

    Authors: Benedito Borges da Silva, Walberto Monteiro Neiva Eulálio Filho, Pedro Vitor Lopes Costa, Rozirene Araújo Silva, Ariton Mendes Conde Junior, Diego Cipriano Chagas, Mariella de Almeida Melo, Fidelis Manes Neto, Cleciton Braga Tavares, Edilson Carvalho de Sousa Júnior, Eid Gonçalves Coelho, Viriato Campelo, Luis Henrique Gebrim and Raimundo Gerônimo da Silva Junior

    Citation: BMC Cancer 2018 18:978

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  35. Content type: Research article

    Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of inducing peritoneal tumor cell dissemination. We investigated the diagnost...

    Authors: Rei Suzuki, Hiroki Irie, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Ko Watanabe, Jun Nakamura, Shigeru Marubashi, Takuto Hikichi and Hiromasa Ohira

    Citation: BMC Cancer 2018 18:974

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  36. Content type: Research article

    The current TNM staging system is far from perfect in predicting the survival of individual non-small cell lung cancer (NSCLC) patients. In this study, we aim to combine clinical variables and molecular biomar...

    Authors: Lei Liu, Minxin Shi, Zhiwei Wang, Haimin Lu, Chang Li, Yu Tao, Xiaoyan Chen and Jun Zhao

    Citation: BMC Cancer 2018 18:966

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  37. Content type: Case report

    Gastric gastrointestinal stromal tumor (GIST), intro-abdominal and retroperitoneal neoplasms are distinct tumors arising from different cell layers; therefore, coexistence of such tumors is relatively rare.

    Authors: Yong Zhou, Xu-Dong Wu, Quan Shi, Chuan-hai Xu and Jing Jia

    Citation: BMC Cancer 2018 18:968

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  38. Content type: Case report

    Gastrointestinal symptoms occur in approximately 50% of patients with systemic lupus erythematous with low specificity. Although it is well established that colon cancer is one of the many gastrointestinal man...

    Authors: Junfeng Shi, Jianquan Fei, Qingqing Yi, Lijuan Shen, Boshun Wan, Yueyu Chen and Qing Chang

    Citation: BMC Cancer 2018 18:961

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  39. Content type: Research article

    The prognosis of patients with epidermal growth factor receptor (EGFR) mutant adenocarcinoma of the lung (Mt) and EGFR wild-type adenocarcinoma (Wt) after complete resection of the lung differ; however, the mecha...

    Authors: Tetsuya Isaka, Haruhiko Nakayama, Hiroyuki Ito, Tomoyuki Yokose, Kouzo Yamada and Munetaka Masuda

    Citation: BMC Cancer 2018 18:959

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  40. Content type: Research article

    Breast cancer related lymphoedema (BCRL) occurs in a substantial proportion of breast cancer survivors and is a major contributor to patients’ disability. Regrettably, there are no validated predictive biomark...

    Authors: Marco Invernizzi, Chiara Corti, Gianluca Lopez, Anna Michelotti, Luca Despini, Donatella Gambini, Daniele Lorenzini, Elena Guerini-Rocco, Stefania Maggi, Marianna Noale and Nicola Fusco

    Citation: BMC Cancer 2018 18:935

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  41. Content type: Case report

    Perianal Paget’s disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may repres...

    Authors: Jéssica Silva dos Santos, Gabriel Alves Bonafé, José Aires Pereira, Danilo Toshio Kanno, Carlos Augusto Real Martinez and Manoela Marques Ortega

    Citation: BMC Cancer 2018 18:921

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  42. Content type: Study protocol

    Biannual ultrasound (US)—with or without alpha-fetoprotein (AFP)—is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been ...

    Authors: Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh and Myeong-Jin Kim

    Citation: BMC Cancer 2018 18:915

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  43. Content type: Research article

    This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).

    Authors: Ruo-Xi Wang, Sheng Chen, Liang Huang and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:909

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  44. Content type: Research article

    Although there has been marked development in surgical techniques, there is no easy and fast method of predicting complications in minimally invasive surgeries. We evaluated whether the modified surgical Apgar...

    Authors: Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2018 18:908

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  45. Content type: Study protocol

    Accurate assessment of liver health prior to undertaking resectional liver surgery or chemoembolisation for primary and secondary cancers is essential for patient safety and optimal outcomes. LiverMultiScan™, an ...

    Authors: Damian J. Mole, Jonathan A. Fallowfield, Timothy J. Kendall, Fenella Welsh, Scott I. Semple, Velicia Bachtiar, Matt Kelly, Stephen J. Wigmore, O. James Garden, Henry R. Wilman, Rajarshi Banerjee, Myrddin Rees and Michael Brady

    Citation: BMC Cancer 2018 18:890

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  46. Content type: Research article

    Resection of the primary tumor is recommended for symptom relief in de novo stage IV breast cancer. We explored whether local surgery could provide a survival benefit in these patients and attempted to charact...

    Authors: Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang and Xi Wang

    Citation: BMC Cancer 2018 18:885

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  47. Content type: Research article

    Local ablative techniques are emerging in patients with oligometastatic disease from colorectal carcinoma, commonly described as less invasive than surgical methods. This single arm cohort seeks to determine w...

    Authors: Ricarda Seidensticker, Robert Damm, Julia Enge, Max Seidensticker, Konrad Mohnike, Maciej Pech, Peter Hass, Holger Amthauer and Jens Ricke

    Citation: BMC Cancer 2018 18:882

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  48. Content type: Research article

    The aim of our study was to investigate whether an inflammation-based prognostic score, the prognostic nutritional index (PNI), was associated with clinical characteristics and prognosis in patients with high-...

    Authors: Zheng Feng, Hao Wen, Xingzhu Ju, Rui Bi, Xiaojun Chen, Wentao Yang and Xiaohua Wu

    Citation: BMC Cancer 2018 18:883

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