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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 16

  1. We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.

    Authors: Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki…

    Citation: BMC Cancer 2021 21:201

    Content type: Research article

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  2. The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effect...

    Authors: Yanrui Liang, Liying Zhao, Hao Chen, Tian Lin, Tao Chen, Mingli Zhao, Yanfeng Hu, Jiang Yu, Hao Liu and Guoxin Li

    Citation: BMC Cancer 2021 21:196

    Content type: Research article

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  3. Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at diagnosis is a very strong indicator of prognosis in PGC. Neverthe...

    Authors: Sung Yong Choi, Eunkyu Lee, Eunhye Kim, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek and Han-Sin Jeong

    Citation: BMC Cancer 2021 21:178

    Content type: Research article

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  4. There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

    Authors: Yuwen Luo, Rongjiang Li, Deqing Wu, Jun Zeng, Junjiang Wang, Xianzhe Chen, Chengzhi Huang, Yong Li and Xueqing Yao

    Citation: BMC Cancer 2021 21:171

    Content type: Research article

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  5. Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with breast cancer. Therefore, the surgeon should distinguish bet...

    Authors: Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Jeong Ju Lee, Hee Jung Keum, Jung Dug Yang, Jeong Woo Lee, Joon Seok Lee and Jin Hyang Jung

    Citation: BMC Cancer 2021 21:166

    Content type: Research article

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  6. The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation thera...

    Authors: Salvatore Paiella, Giuseppe Malleo, Nicola Simoni, Renato Micera, Stefania Guariglia, Carlo Cavedon, Giovanni Marchegiani, Alessandro Esposito, Luca Landoni, Luca Casetti, Massimiliano Tuveri, Michele Milella, Erica Secchettin, Gessica Manzini, Chiara Bovo, Matteo De Pastena…

    Citation: BMC Cancer 2021 21:165

    Content type: Study protocol

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  7. Patients with gastric cancer have an increased nutritional risk and experience a significant skeletal muscle loss after surgery. We aimed to determine whether muscle loss during the first postoperative year an...

    Authors: Kyung Won Kim, Koeun Lee, Jung-Bok Lee, Taeyong Park, Seungwoo Khang, Heeryeol Jeong, Chang-Seok Ko, Jeong-Hwan Yook, Byung-Sik Kim and In-Seob Lee

    Citation: BMC Cancer 2021 21:157

    Content type: Research article

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  8. Lung cancer remains the leading cause of cancer death globally. In 2015, the cancer classification guidelines of the World Health Organization were updated. The term “invasive mucinous adenocarcinoma (IMA)” ar...

    Authors: Yadong Wang, Jichang Liu, Cuicui Huang, Yukai Zeng, Yong Liu and Jiajun Du

    Citation: BMC Cancer 2021 21:148

    Content type: Research article

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  9. Although previous studies have discussed whether the minimally invasive esophagectomy (MIE) is superior to open surgery, the data concerning esophageal squamous cell carcinoma (ESCC) patients underwent neoadju...

    Authors: Dongni Chen, Weidong Wang, Junxian Mo, Qiannan Ren, Huikai Miao, Youfang Chen and Zhesheng Wen

    Citation: BMC Cancer 2021 21:145

    Content type: Research article

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  10. The identification of factors responsible for false negative (FN) rate at 18F- Fluorodeoxyglucose (FDG) Positron Emission Tomography /Computed Tomography (PET/CT) in para-aortic (PA) lymph nodes in the presurgica...

    Authors: Sebastien Gouy, Veronika Seebacher, Cyrus Chargari, Marie Terroir, Serena Grimaldi, Anna Ilenko, Amandine Maulard, Catherine Genestie, Alexandra Leary, Patricia Pautier, Philippe Morice and Désirée Deandreis

    Citation: BMC Cancer 2021 21:135

    Content type: Research article

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  11. To evaluate the clinical efficacy and safety of ablating renal cell carcinoma (RCC) by irreversible electroporation (IRE).

    Authors: Ziyin Wang, Jian Lu, Wei Huang, Zhiyuan Wu, Ju Gong, Qingbing Wang, Qin Liu, Cangyi Wang, Yu Zhu, Xiaoyi Ding and Zhongmin Wang

    Citation: BMC Cancer 2021 21:124

    Content type: Research article

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  12. The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This ...

    Authors: Yu-jie Liang, Xue-ying Mei, Bin Zeng, Si-en Zhang, Le Yang, Xiao-mei Lao and Gui-qing Liao

    Citation: BMC Cancer 2021 21:122

    Content type: Research article

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  13. Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the vali...

    Authors: Yacir El Alami, Hajar Essangri, Mohammed Anass Majbar, Saber Boutayeb, Said Benamr, Hadj Omar El Malki and Amine Souadka

    Citation: BMC Cancer 2021 21:99

    Content type: Research article

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  14. Postoperative complications have been linked to the morbidity and mortality of several cancers. However, predicting whether complications will occur in the early period after surgery or not is challenging. Hen...

    Authors: Keishi Okubo, Takaaki Arigami, Daisuke Matsushita, Takashi Kijima, Masataka Shimonosono, Yoshikazu Uenosono, Shigehiro Yanagita, Hiroshi Kurahara, Shinichiro Mori, Takao Ohtsuka and Shoji Natsugoe

    Citation: BMC Cancer 2021 21:95

    Content type: Research article

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  15. Endoscopic submucosal dissection (ESD) is gaining enormous popularity in the treatment of early gastric cancers (EGCs) in many institutions across the world. However, appropriate selection of candidates for en...

    Authors: Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang and Xi Wang

    Citation: BMC Cancer 2021 21:92

    Content type: Research article

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  16. Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine sta...

    Authors: I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma…

    Citation: BMC Cancer 2021 21:90

    Content type: Research article

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  17. Immediate breast reconstruction with tissue expander in breast cancer patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate. Postoperative com...

    Authors: Sung Mi Jung, Byung-Joon Jeon, Jinsun Woo, Jai Min Ryu, Se Kyung Lee, Byung-Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jai-Kyong Pyon, Goo-Hyun Mun, Sa Ik Bang and Jeong Eon Lee

    Citation: BMC Cancer 2021 21:88

    Content type: Research article

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  18. Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption.

    Authors: Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo and Wei Hua

    Citation: BMC Cancer 2021 21:83

    Content type: Research article

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  19. Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. This study aims to examine t...

    Authors: Jieqiong Wen, Wanbin Chen, Yayun Zhu and Pengbo Zhang

    Citation: BMC Cancer 2021 21:81

    Content type: Research article

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  20. Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor...

    Authors: Shao-Hao Chen, Long-Yao Xu, Yu-Peng Wu, Zhi-Bin Ke, Peng Huang, Fei Lin, Xiao-Dong Li, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng and Ning Xu

    Citation: BMC Cancer 2021 21:79

    Content type: Research article

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  21. The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce a...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler, Lale Umutlu, Maurizio Conti, Pedro Fragoso Costa, Miriam Sraieb and David Kersting

    Citation: BMC Cancer 2021 21:62

    Content type: Research article

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  22. Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new ...

    Authors: Matthias E. Meunier, Pascal Blanchet, Yann Neuzillet, Thierry Lebret and Laurent Brureau

    Citation: BMC Cancer 2021 21:61

    Content type: Research article

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  23. Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectom...

    Authors: Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying…

    Citation: BMC Cancer 2021 21:56

    Content type: Study protocol

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  24. Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, i...

    Authors: Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis…

    Citation: BMC Cancer 2021 21:51

    Content type: Study protocol

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  25. This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated with cytoreductive surgery ...

    Authors: Sicheng Zhou, Qiang Feng, Jing Zhang, Haitao Zhou, Zheng Jiang, Zheng Liu, Zhaoxu Zheng, Haipeng Chen, Zheng Wang, Jianwei Liang, Wei Pei, Qian Liu, Zhixiang Zhou and Xishan Wang

    Citation: BMC Cancer 2021 21:41

    Content type: Research article

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  26. Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 an...

    Authors: Keisuke Miwa, Eiji Oki, Masanobu Enomoto, Keisuke Ihara, Koji Ando, Fumihiko Fujita, Masahiro Tominaga, Shinichiro Mori, Goro Nakayama, Mototsugu Shimokawa, Hiroshi Saeki, Hideo Baba, Masaki Mori and Yoshito Akagi

    Citation: BMC Cancer 2021 21:23

    Content type: Research article

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  27. An accurate intraoperative prediction of lymph node metastatic risk can help surgeons in choosing precise surgical procedures. We aimed to develop and validate nomograms to intraoperatively predict patterns of...

    Authors: Fei Zhao, Rong-Xin Lu, Jin-Yuan Liu, Jun Fan, Hao-Ran Lin, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Fu-Xi Zhen, Jin-Hua Luo and Wei Wang

    Citation: BMC Cancer 2021 21:22

    Content type: Research article

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  28. Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. ...

    Authors: Xinxin Wang, Shuo Li, Yihong Sun, Kai Li, Xian Shen, Yingwei Xue, Pin Liang, Guoli Li, Luchuan Chen, Qun Zhao, Guoxin Li, Weihua Fu, Han Liang, Hairong Xin, Jian Suo, Xuedong Fang…

    Citation: BMC Cancer 2021 21:20

    Content type: Study protocol

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  29. Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still ...

    Authors: Antonella Vecchiato, Simone Mocellin, Paolo Del Fiore, Giulio Tosti, Paolo A. Ascierto, Maria Teresa Corradin, Vincenzo De Giorgi, Giuseppe Giudice, Paola Queirolo, Caterina Ferreli, Marcella Occelli, Monica Giordano, Giusto Trevisan, Luigi Mascheroni, Alessandro Testori, Romina Spina…

    Citation: BMC Cancer 2021 21:8

    Content type: Research article

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  30. Lymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-...

    Authors: Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine and Kenji Sugio

    Citation: BMC Cancer 2020 20:1192

    Content type: Research article

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  31. Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relation...

    Authors: Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi and Wataru Takayama

    Citation: BMC Cancer 2020 20:1184

    Content type: Research article

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  32. Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment. Howeve...

    Authors: Saumil Datar, Maria Cabanillas, Ramona Dadu, David Ost and Horiana B. Grosu

    Citation: BMC Cancer 2020 20:1181

    Content type: Research article

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  33. Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. The aim of this study is therefore ...

    Authors: Shi Yeung Ho and Raymond King Yin Tsang

    Citation: BMC Cancer 2020 20:1172

    Content type: Research article

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  34. The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definiti...

    Authors: Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa…

    Citation: BMC Cancer 2020 20:1169

    Content type: Research article

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  35. Papillary thyroid cancer (PTC) is unique among cancers in that patient age is a consideration in staging. One of the most important modifications in the 8th Edition of the American Joint Committee on Cancer (A...

    Authors: Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Beata Wojtczak and Jerzy Rudnicki

    Citation: BMC Cancer 2020 20:1166

    Content type: Research article

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  36. The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure...

    Authors: Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk and Andrew G. Renehan

    Citation: BMC Cancer 2020 20:1165

    Content type: Research article

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  37. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao

    Citation: BMC Cancer 2020 20:1158

    Content type: Research article

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  38. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy

    Citation: BMC Cancer 2020 20:1147

    Content type: Research article

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  39. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang

    Citation: BMC Cancer 2020 20:1129

    Content type: Research article

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  40. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang

    Citation: BMC Cancer 2020 20:1120

    Content type: Research article

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  41. There is no currently available treatment for peritoneal metastasis of gastric cancer. This phase II study aimed to evaluate the efficacy and safety of neoadjuvant systemic chemotherapy and hyperthermic intrap...

    Authors: Pengfei Yu, Zeyao Ye, Gaiguo Dai, Yanqiang Zhang, Ling Huang, Yian Du and Xiangdong Cheng

    Citation: BMC Cancer 2020 20:1108

    Content type: Research article

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  42. Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a v...

    Authors: Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume and Gro Wiedswang

    Citation: BMC Cancer 2020 20:1107

    Content type: Research article

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  43. AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi and Fumio Imamura

    Citation: BMC Cancer 2020 20:1100

    Content type: Research article

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  44. The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of un...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi and Hiromasa Ohira

    Citation: BMC Cancer 2020 20:1094

    Content type: Research article

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  45. This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic sc...

    Authors: Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima and Yukihide Kanemitsu

    Citation: BMC Cancer 2020 20:1092

    Content type: Research article

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  46. This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.

    Authors: Feng Xu, Jian Song, Beizheng Xu, Jiang Wang, Jianjun Mao, Haiyan Liu, Xuanmei Li and Aibing Deng

    Citation: BMC Cancer 2020 20:1089

    Content type: Research article

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