Skip to main content

Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 16

  1. Astrocytoma is a common type of central nervous system tumor. In this study, we investigated the correlation between ST6GAL1 and CYP19A1 polymorphisms and the risk and prognosis of astrocytoma.

    Authors: Tuo Wang, Yao Sun, Zichao Xiong, Jiamin Wu, Xiaoying Ding, Xiaoye Guo and Yuan Shao

    Citation: BMC Cancer 2021 21:391

    Content type: Research article

    Published on:

  2. Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) is extensively applied to treat benign and low-grade diseases relat...

    Authors: Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang, Guan-yu Wang, Xian-fa Wang, Yi-ping Mou and Jia-fei Yan

    Citation: BMC Cancer 2021 21:382

    Content type: Research article

    Published on:

  3. Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood.

    Authors: Amy Hawarden, Bryn Russell, Mary Ellen Gee, Fatima Skayali, Andrew Clamp, Emma Jayne Crosbie and Richard John Edmondson

    Citation: BMC Cancer 2021 21:378

    Content type: Research article

    Published on:

  4. Given their widespread availability and relatively low cost, percutaneous thermal ablation is commonly performed under the guidance of computed tomography (CT) or ultrasound (US). However, such imaging modalit...

    Authors: Zhaonan Li, Chaoyan Wang, Guangyan Si, Xueliang Zhou, Yahua Li, Jing Li, Dechao Jiao and Xinwei Han

    Citation: BMC Cancer 2021 21:366

    Content type: Research article

    Published on:

  5. Angiogenesis assessment is important for personalized therapeutic intervention in patients with non-small-cell lung cancer (NSCLC). This study investigated whether radiologic parameters obtained by dynamic con...

    Authors: Yu-Sen Huang, Jenny Ling-Yu Chen, Hsin-Ming Chen, Li-Hao Yeh, Jin-Yuan Shih, Ruoh-Fang Yen and Yeun-Chung Chang

    Citation: BMC Cancer 2021 21:348

    Content type: Research article

    Published on:

  6. The present study aimed to assess the lower invasiveness of robot-assisted transmediastinal radical esophagectomy by prospectively comparing this procedure with transthoracic esophagectomy in terms of perioper...

    Authors: Shuntaro Yoshimura, Kazuhiko Mori, Motonari Ri, Susumu Aikou, Koichi Yagi, Yukinori Yamagata, Masato Nishida, Hiroharu Yamashita, Sachiyo Nomura and Yasuyuki Seto

    Citation: BMC Cancer 2021 21:338

    Content type: Research article

    Published on:

  7. Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with malignant behaviors that can develop from inert slow growth or low malignancy to aggressive metastasis during follow-up. Rec...

    Authors: Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li and Sheng Yan

    Citation: BMC Cancer 2021 21:334

    Content type: Research article

    Published on:

  8. Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC). We conducted this research to investigate the clinical characteristics and outcomes of OCCC and to prov...

    Authors: Chenchen Zhu, Jing Zhu, Lili Qian, Hanyuan Liu, Zhen Shen, Dabao Wu, Weidong Zhao, Weihua Xiao and Ying Zhou

    Citation: BMC Cancer 2021 21:322

    Content type: Research article

    Published on:

  9. Breast cancer and its treatment imposes a significant effect in the quality of life (QOL) of women. Being a developing country with contrasting social and cultural norms to the West, Sri Lankan women may have ...

    Authors: Ravindri Jayasinghe, Ashan Fernando, Umesh Jayarajah and Sanjeewa Seneviratne

    Citation: BMC Cancer 2021 21:305

    Content type: Research article

    Published on:

  10. Neoadjuvant therapy has several potential advantages over upfront surgery in patients with localized pancreatic cancer; more patients receive systemic treatment, fewer patients undergo futile surgery, and R0 r...

    Authors: Q. P. Janssen, J. L. van Dam, B. A. Bonsing, H. Bos, K. P. Bosscha, P. P. L. O. Coene, C. H. J. van Eijck, I. H. J. T. de Hingh, T. M. Karsten, M. B. van der Kolk, G. A. Patijn, M. S. L. Liem, H. C. van Santvoort, O. J. L. Loosveld, J. de Vos-Geelen, B. M. Zonderhuis…

    Citation: BMC Cancer 2021 21:300

    Content type: Study protocol

    Published on:

  11. Breast cancer-related lymphedema (BCRL) is associated with extensive axillary dissection. Axillary lymph node dissection (ALND) based on breast lymphatics level (BLL) was proposed to minimize the surgical exte...

    Authors: Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng and Gaosong Wu

    Citation: BMC Cancer 2021 21:293

    Content type: Research article

    Published on:

  12. If the depth of gallbladder malignant tumor (GBMT) invasion is deeper than the subserosa (ss), cholecystectomy is insufficient. In past reports that used endoscopic ultrasonography (EUS) to diagnose the depth ...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi…

    Citation: BMC Cancer 2021 21:288

    Content type: Technical advance

    Published on:

  13. The accurate prediction of post-hepatectomy early recurrence (PHER) of hepatocellular carcinoma (HCC) is vital in determining postoperative adjuvant treatment and monitoring. This study aimed to develop and va...

    Authors: Rong-yun Mai, Jie Zeng, Wei-da Meng, Hua-ze Lu, Rong Liang, Yan Lin, Guo-bin Wu, Le-qun Li, Liang Ma, Jia-zhou Ye and Tao Bai

    Citation: BMC Cancer 2021 21:283

    Content type: Research article

    Published on:

  14. Although criteria for liver transplantation, such as the Milan criteria and Hangzhou experiences, have become popular, criteria to guide adjuvant therapy for patients with hepatocellular carcinoma after liver ...

    Authors: Dabing Huang, Yinan Shen, Wei Zhang, Chengxiang Guo, Tingbo Liang and Xueli Bai

    Citation: BMC Cancer 2021 21:280

    Content type: Research article

    Published on:

  15. Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

    Authors: Jun-Yi Wu, Ju-Xian Sun, Jia-Yi Wu, Xiao-Xiao Huang, Yan-Nan Bai, Yong-Yi Zeng, Zhi-Bo Zhang, Shu-Qun Cheng and Mao-Lin Yan

    Citation: BMC Cancer 2021 21:272

    Content type: Research article

    Published on:

  16. Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine le...

    Authors: Sho Kiritani, Kentaro Yoshimura, Junichi Arita, Takashi Kokudo, Hiroyuki Hakoda, Meguri Tanimoto, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Sen Takeda and Kiyoshi Hasegawa

    Citation: BMC Cancer 2021 21:262

    Content type: Research article

    Published on:

  17. The aim of this study was to investigate the relationship between multiple metabolism parameters derived from FDG and tumor TNM stages as well as tumor metastasis-associated protein of GLUT-1 and MACC1 in colo...

    Authors: Mingyu Zhang, Jigang Yang, Hao Jiang, Huijie Jiang and Zhenchang Wang

    Citation: BMC Cancer 2021 21:258

    Content type: Research article

    Published on:

  18. The current standard postoperative treatment for stage II-IIIA non-small cell lung cancer (NSCLC) is a regimen of platinum doublet adjuvant chemotherapy. These regimens, which are the same as for solid NSCLC t...

    Authors: Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Shoji Tokunaga, Hiroyuki Yamaguchi, Koichi Tomoshige, Hironosuke Watanabe, Takeshi Nagayasu and Kenji Sugio

    Citation: BMC Cancer 2021 21:249

    Content type: Study protocol

    Published on:

  19. Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), whic...

    Authors: Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto and Tomoharu Sugie

    Citation: BMC Cancer 2021 21:239

    Content type: Research article

    Published on:

  20. Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed...

    Authors: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Akira Sakurada, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara…

    Citation: BMC Cancer 2021 21:235

    Content type: Research article

    Published on:

  21. The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast c...

    Authors: Zhangheng Huang, Xin Zhou, Yuexin Tong, Lujian Zhu, Ruhan Zhao and Xiaohui Huang

    Citation: BMC Cancer 2021 21:222

    Content type: Research article

    Published on:

  22. Predicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investiga...

    Authors: Ying Zou, Huanlei Zhang, Wenfei Li, Yu Guo, Fang Sun, Yan Shi, Yan Gong, Xiudi Lu, Wei Wang and Shuang Xia

    Citation: BMC Cancer 2021 21:221

    Content type: Research article

    Published on:

  23. We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.

    Authors: Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki…

    Citation: BMC Cancer 2021 21:201

    Content type: Research article

    Published on:

  24. The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effect...

    Authors: Yanrui Liang, Liying Zhao, Hao Chen, Tian Lin, Tao Chen, Mingli Zhao, Yanfeng Hu, Jiang Yu, Hao Liu and Guoxin Li

    Citation: BMC Cancer 2021 21:196

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:298

  25. Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at diagnosis is a very strong indicator of prognosis in PGC. Neverthe...

    Authors: Sung Yong Choi, Eunkyu Lee, Eunhye Kim, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek and Han-Sin Jeong

    Citation: BMC Cancer 2021 21:178

    Content type: Research article

    Published on:

  26. There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

    Authors: Yuwen Luo, Rongjiang Li, Deqing Wu, Jun Zeng, Junjiang Wang, Xianzhe Chen, Chengzhi Huang, Yong Li and Xueqing Yao

    Citation: BMC Cancer 2021 21:171

    Content type: Research article

    Published on:

  27. Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with breast cancer. Therefore, the surgeon should distinguish bet...

    Authors: Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Jeong Ju Lee, Hee Jung Keum, Jung Dug Yang, Jeong Woo Lee, Joon Seok Lee and Jin Hyang Jung

    Citation: BMC Cancer 2021 21:166

    Content type: Research article

    Published on:

  28. The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation thera...

    Authors: Salvatore Paiella, Giuseppe Malleo, Nicola Simoni, Renato Micera, Stefania Guariglia, Carlo Cavedon, Giovanni Marchegiani, Alessandro Esposito, Luca Landoni, Luca Casetti, Massimiliano Tuveri, Michele Milella, Erica Secchettin, Gessica Manzini, Chiara Bovo, Matteo De Pastena…

    Citation: BMC Cancer 2021 21:165

    Content type: Study protocol

    Published on:

  29. Patients with gastric cancer have an increased nutritional risk and experience a significant skeletal muscle loss after surgery. We aimed to determine whether muscle loss during the first postoperative year an...

    Authors: Kyung Won Kim, Koeun Lee, Jung-Bok Lee, Taeyong Park, Seungwoo Khang, Heeryeol Jeong, Chang-Seok Ko, Jeong-Hwan Yook, Byung-Sik Kim and In-Seob Lee

    Citation: BMC Cancer 2021 21:157

    Content type: Research article

    Published on:

  30. Lung cancer remains the leading cause of cancer death globally. In 2015, the cancer classification guidelines of the World Health Organization were updated. The term “invasive mucinous adenocarcinoma (IMA)” ar...

    Authors: Yadong Wang, Jichang Liu, Cuicui Huang, Yukai Zeng, Yong Liu and Jiajun Du

    Citation: BMC Cancer 2021 21:148

    Content type: Research article

    Published on:

  31. Although previous studies have discussed whether the minimally invasive esophagectomy (MIE) is superior to open surgery, the data concerning esophageal squamous cell carcinoma (ESCC) patients underwent neoadju...

    Authors: Dongni Chen, Weidong Wang, Junxian Mo, Qiannan Ren, Huikai Miao, Youfang Chen and Zhesheng Wen

    Citation: BMC Cancer 2021 21:145

    Content type: Research article

    Published on:

  32. The identification of factors responsible for false negative (FN) rate at 18F- Fluorodeoxyglucose (FDG) Positron Emission Tomography /Computed Tomography (PET/CT) in para-aortic (PA) lymph nodes in the presurgica...

    Authors: Sebastien Gouy, Veronika Seebacher, Cyrus Chargari, Marie Terroir, Serena Grimaldi, Anna Ilenko, Amandine Maulard, Catherine Genestie, Alexandra Leary, Patricia Pautier, Philippe Morice and Désirée Deandreis

    Citation: BMC Cancer 2021 21:135

    Content type: Research article

    Published on:

  33. To evaluate the clinical efficacy and safety of ablating renal cell carcinoma (RCC) by irreversible electroporation (IRE).

    Authors: Ziyin Wang, Jian Lu, Wei Huang, Zhiyuan Wu, Ju Gong, Qingbing Wang, Qin Liu, Cangyi Wang, Yu Zhu, Xiaoyi Ding and Zhongmin Wang

    Citation: BMC Cancer 2021 21:124

    Content type: Research article

    Published on:

  34. The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This ...

    Authors: Yu-jie Liang, Xue-ying Mei, Bin Zeng, Si-en Zhang, Le Yang, Xiao-mei Lao and Gui-qing Liao

    Citation: BMC Cancer 2021 21:122

    Content type: Research article

    Published on:

  35. Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the vali...

    Authors: Yacir El Alami, Hajar Essangri, Mohammed Anass Majbar, Saber Boutayeb, Said Benamr, Hadj Omar El Malki and Amine Souadka

    Citation: BMC Cancer 2021 21:99

    Content type: Research article

    Published on:

  36. Postoperative complications have been linked to the morbidity and mortality of several cancers. However, predicting whether complications will occur in the early period after surgery or not is challenging. Hen...

    Authors: Keishi Okubo, Takaaki Arigami, Daisuke Matsushita, Takashi Kijima, Masataka Shimonosono, Yoshikazu Uenosono, Shigehiro Yanagita, Hiroshi Kurahara, Shinichiro Mori, Takao Ohtsuka and Shoji Natsugoe

    Citation: BMC Cancer 2021 21:95

    Content type: Research article

    Published on:

  37. Endoscopic submucosal dissection (ESD) is gaining enormous popularity in the treatment of early gastric cancers (EGCs) in many institutions across the world. However, appropriate selection of candidates for en...

    Authors: Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang and Xi Wang

    Citation: BMC Cancer 2021 21:92

    Content type: Research article

    Published on:

  38. Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine sta...

    Authors: I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma…

    Citation: BMC Cancer 2021 21:90

    Content type: Research article

    Published on:

  39. Immediate breast reconstruction with tissue expander in breast cancer patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate. Postoperative com...

    Authors: Sung Mi Jung, Byung-Joon Jeon, Jinsun Woo, Jai Min Ryu, Se Kyung Lee, Byung-Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jai-Kyong Pyon, Goo-Hyun Mun, Sa Ik Bang and Jeong Eon Lee

    Citation: BMC Cancer 2021 21:88

    Content type: Research article

    Published on:

  40. Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption.

    Authors: Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo and Wei Hua

    Citation: BMC Cancer 2021 21:83

    Content type: Research article

    Published on:

  41. Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. This study aims to examine t...

    Authors: Jieqiong Wen, Wanbin Chen, Yayun Zhu and Pengbo Zhang

    Citation: BMC Cancer 2021 21:81

    Content type: Research article

    Published on:

  42. Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor...

    Authors: Shao-Hao Chen, Long-Yao Xu, Yu-Peng Wu, Zhi-Bin Ke, Peng Huang, Fei Lin, Xiao-Dong Li, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng and Ning Xu

    Citation: BMC Cancer 2021 21:79

    Content type: Research article

    Published on:

  43. The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce a...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler, Lale Umutlu, Maurizio Conti, Pedro Fragoso Costa, Miriam Sraieb and David Kersting

    Citation: BMC Cancer 2021 21:62

    Content type: Research article

    Published on:

  44. Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new ...

    Authors: Matthias E. Meunier, Pascal Blanchet, Yann Neuzillet, Thierry Lebret and Laurent Brureau

    Citation: BMC Cancer 2021 21:61

    Content type: Research article

    Published on:

  45. Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectom...

    Authors: Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying…

    Citation: BMC Cancer 2021 21:56

    Content type: Study protocol

    Published on:

  46. Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, i...

    Authors: Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis…

    Citation: BMC Cancer 2021 21:51

    Content type: Study protocol

    Published on:

  47. This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated with cytoreductive surgery ...

    Authors: Sicheng Zhou, Qiang Feng, Jing Zhang, Haitao Zhou, Zheng Jiang, Zheng Liu, Zhaoxu Zheng, Haipeng Chen, Zheng Wang, Jianwei Liang, Wei Pei, Qian Liu, Zhixiang Zhou and Xishan Wang

    Citation: BMC Cancer 2021 21:41

    Content type: Research article

    Published on:

\