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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 13

  1. The influence of perioperative blood transfusion (PBT) on postsurgical survival of patients with different stage of hepatocellular carcinoma (HCC) is not well clarified. This study aimed to evaluate the impact...

    Authors: Gui-Xing Chen, Chao-Ying Qi, Wen-Jie Hu, Xiao-Hui Wang, Yun-Peng Hua, Ming Kuang, Bao-Gang Peng and Shao-Qiang Li

    Citation: BMC Cancer 2020 20:487

    Content type: Research article

    Published on:

  2. Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown t...

    Authors: Antoine Brouquet, Jean-Baptiste Bachet, Florence Huguet, Mehdi Karoui, Pascal Artru, Charles Sabbagh, Jérémie H. Lefèvre, Dewi Vernerey, Christophe Mariette, Eric Vicaut and Stephane Benoist

    Citation: BMC Cancer 2020 20:485

    Content type: Study protocol

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  3. Repeat transarterial chemoembolisation (rTACE) is often required for hepatocellular carcinoma (HCC) to achieve disease control, however, current practice guidelines regarding treatment allocation vary signific...

    Authors: Gauri Mishra, Anouk Dev, Eldho Paul, Wa Cheung, Jim Koukounaras, Ashu Jhamb, Ben Marginson, Beng Ghee Lim, Paul Simkin, Adina Borsaru, James Burnes, Mark Goodwin, Vivek Ramachandra, Manfred Spanger, John Lubel, Paul Gow…

    Citation: BMC Cancer 2020 20:483

    Content type: Research article

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  4. High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritone...

    Authors: Agata Mikolajczyk, Tanja Khosrawipour, Joanna Kulas, Pawel Migdal, Mohamed Arafkas, Jakub Nicpon and Veria Khosrawipour

    Citation: BMC Cancer 2020 20:481

    Content type: Research article

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  5. Neoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients’ responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatme...

    Authors: Kai-Yu Sun, Hang-Tong Hu, Shu-Ling Chen, Jin-Ning Ye, Guang-Hua Li, Li-Da Chen, Jian-Jun Peng, Shi-Ting Feng, Yu-Jie Yuan, Xun Hou, Hui Wu, Xin Li, Ting-Fan Wu, Wei Wang and Jian-Bo Xu

    Citation: BMC Cancer 2020 20:468

    Content type: Research article

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  6. Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients’ outcomes inclu...

    Authors: T. M. Ripping, L. A. Kiemeney, L. M. C. van Hoogstraten, J. A. Witjes and K. K. H. Aben

    Citation: BMC Cancer 2020 20:455

    Content type: Study protocol

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  7. The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margi...

    Authors: Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen and Dar-Ren Chen

    Citation: BMC Cancer 2020 20:451

    Content type: Research article

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  8. The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent...

    Authors: Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella M. Björkman-Burtscher, Helena Carén and Asgeir Store Jakola

    Citation: BMC Cancer 2020 20:450

    Content type: Research article

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  9. Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

    Authors: Paula Whitmire, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco Jr, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-de los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej M. Mrugala…

    Citation: BMC Cancer 2020 20:447

    Content type: Research article

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  10. To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as t...

    Authors: Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng and Rongqin Zheng

    Citation: BMC Cancer 2020 20:419

    Content type: Research article

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  11. Neurosurgical resection represents an important treatment option in the modern, multimodal therapy approach of brain metastases (BM). Guidelines for perioperative imaging exist for primary brain tumors to guid...

    Authors: Barbara Kiesel, Carina M. Thomé, Tobias Weiss, Asgeir S. Jakola, Amélie Darlix, Alessia Pellerino, Julia Furtner, Johannes Kerschbaumer, Christian F. Freyschlag, Wolfgang Wick, Matthias Preusser, Georg Widhalm and Anna S. Berghoff

    Citation: BMC Cancer 2020 20:410

    Content type: Research article

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  12. The prognosis of patients with perihilar cholangiocarcinoma have been unsatisfactory. We established new anatomical resectability classification for patients with localized perihilar cholangiocarcinoma and per...

    Authors: Naohisa Kuriyama, Masanobu Usui, Kazuaki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno and Shuji Isaji

    Citation: BMC Cancer 2020 20:405

    Content type: Research article

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  13. Primary debulking surgery (PDS) and adjuvant chemotherapy is the standard treatment for advanced ovarian, fallopian or primary peritoneal cancer. However, neoadjuvant chemotherapy (NAC) followed by interval de...

    Authors: Soo Jin Park, Seung-Hyuk Shim, Yong-Il Ji, Sang-Hoon Kwon, Eun Ji Lee, Maria Lee, Suk Joon Chang, Samina Park, Sang Youn Kim, Sung Jong Lee, Jae-Weon Kim, Ju-Won Roh, San Hui Lee, Taejong Song and Hee Seung Kim

    Citation: BMC Cancer 2020 20:385

    Content type: Study protocol

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  14. In randomized controlled trials (RCTs) of adjuvant treatment for malignant tumors, event-free survival (EFS) is considered the most acceptable surrogate for overall survival (OS). However, even though EFS has ...

    Authors: Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga and Hiroshi Tsumura

    Citation: BMC Cancer 2020 20:379

    Content type: Research article

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  15. While the new Gleason grade grouping (GGG), which started in 2016, has been widely validated in prostate cancer, it does not incorporate the concept of tertiary Gleason pattern 5. Furthermore, no study has “qu...

    Authors: Satoru Taguchi, Yukari Uemura, Tetsuya Fujimura, Teppei Morikawa, Akihiro Naito, Taketo Kawai, Motofumi Suzuki, Haruki Kume and Hiroshi Fukuhara

    Citation: BMC Cancer 2020 20:371

    Content type: Research article

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  16. Conversion surgery (CS) following a response to chemotherapy occasionally leads to prolonged survival in patients with stage IV gastric cancer (GC). This study aimed to evaluate the predictive value of the neu...

    Authors: Naohiko Nakamura, Shinichi Kinami, Yasuto Tomita, Takashi Miyata, Hideto Fujita, Hiroyuki Takamura, Nobuhiko Ueda and Takeo Kosaka

    Citation: BMC Cancer 2020 20:363

    Content type: Research article

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  17. Stereotactic irradiation (STI) is a primary treatment for patients with newly diagnosed brain metastases. Some of these patients experience local progression, which is difficult to differentiate from radiation...

    Authors: Koichi Mitsuya, Yoko Nakasu, Nakamasa Hayashi, Shoichi Deguchi, Takuma Oishi, Takashi Sugino, Kazuaki Yasui, Hirofumi Ogawa, Tsuyoshi Onoe, Hirofumi Asakura and Hideyuki Harada

    Citation: BMC Cancer 2020 20:331

    Content type: Research article

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  18. Pelvic lymph node dissection (PLND) is one of the most important steps in radical prostatectomy (RP). Not only can PLND provide accurate clinical staging to guide treatment after prostatectomy but PLND can als...

    Authors: Jia-Jun Chen, Zai-Sheng Zhu, Yi-Yi Zhu and Hong-Qi Shi

    Citation: BMC Cancer 2020 20:330

    Content type: Research article

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  19. To discuss some inaccurate parts of a published systematic review and meta-analysis which was about comparison of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy for pancreatic ductal ade...

    Authors: Rui Sun, Yifan Zhang and Zhe Su

    Citation: BMC Cancer 2020 20:327

    Content type: Correspondence

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    The original article was published in BMC Cancer 2019 19:781

  20. Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTRs), which is the molecular basis for 68Ga-DOTATOC positron-emission tomography (PET) and radiopeptide therapy (PRRT). However, SSTR ...

    Authors: Manuel Weber, Lukas Kessler, Benedikt Schaarschmidt, Wolfgang Peter Fendler, Harald Lahner, Gerald Antoch, Lale Umutlu, Ken Herrmann and Christoph Rischpler

    Citation: BMC Cancer 2020 20:326

    Content type: Research article

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  21. Response evaluation of neoadjuvant chemotherapy (NACT) in patients with osteosarcoma is significant for the termination of ineffective treatment, the development of postoperative chemotherapy regimens, and the...

    Authors: Bingsheng Huang, Jifei Wang, Meili Sun, Xin Chen, Danyang Xu, Zi-Ping Li, Jinting Ma, Shi-Ting Feng and Zhenhua Gao

    Citation: BMC Cancer 2020 20:322

    Content type: Research article

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  22. The aim of this systematic review and meta-analysis was to compare overall survival and disease-free survival after fertility sparing surgery (FSS) vs radical surgery in stage 1 epithelial ovarian cancer (EOC).

    Authors: Denghua Liu, Jing Cai, Aiwei Gao, Zehua Wang and Liqiong Cai

    Citation: BMC Cancer 2020 20:320

    Content type: Research article

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  23. Isocitrate dehydrogenase 1/2 (IDH1/2), BAP1, ARID1A and PBRM1 have been reported as the most frequent mutant genes in intrahepatic cholangiocarcinoma (ICC), and their relationships with clinicopathological fea...

    Authors: Bingqi Ma, Huijuan Meng, Ye Tian, Yingying Wang, Tianqiang Song, Ti Zhang, Qiang Wu, Yunlong Cui, Huikai Li, Wei Zhang and Qiang Li

    Citation: BMC Cancer 2020 20:318

    Content type: Research article

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  24. Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has...

    Authors: Hai-Bo Sun, Wen-Qun Xing, Xian-Ben Liu, Yan Zheng, Shu-Jun Yang, Zong-Fei Wang, Shi-Lei Liu, Yu-Feng Ba, Rui-Xiang Zhang, Bao-Xing Liu, Cheng-Cheng Fan, Pei-Nan Chen, Guang-Hui Liang, Yong-Kui Yu, Qi Liu, Hao-Ran Wang…

    Citation: BMC Cancer 2020 20:303

    Content type: Study protocol

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  25. The objective of the IMPROVE study was patients’ preference for either endocrine-based therapy or combined chemo- and anti-angiogenic therapy in advanced HR-positive/HER2-negative breast cancer.

    Authors: Thomas Decker, Ulrike Söling, Antje Hahn, Christoph Maintz, Christian Martin Kurbacher, Ursula Vehling-Kaiser, Dagmar Sent, Peter Klare, Volker Hagen, Marco Chiabudini, Julia Falkenstein, Martin Indorf, Eva Runkel and Karin Potthoff

    Citation: BMC Cancer 2020 20:286

    Content type: Research article

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  26. Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.

    Authors: Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi and Wansheng Long

    Citation: BMC Cancer 2020 20:274

    Content type: Research article

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  27. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco

    Citation: BMC Cancer 2020 20:271

    Content type: Case report

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  28. In the past four decades, the incidence of cholangiocarcinoma, especially intrahepatic cholangiocarcinoma (ICC), has raised rapidly worldwide. Completeness of resection, max size of tumor and etc. are widely r...

    Authors: Zeyu Zhang, Yufan Zhou, Kuan Hu, Dong Wang, Zhiming Wang and Yun Huang

    Citation: BMC Cancer 2020 20:270

    Content type: Research article

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  29. Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the fi...

    Authors: John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski and Naris Nilubol

    Citation: BMC Cancer 2020 20:256

    Content type: Case report

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  30. Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...

    Authors: Zerong Cai, Xiaoyu Xie, Yufeng Chen, Zexian Chen, Wuteng Cao, Khamis Salem Saeed Saad, Yifeng Zou, Ping Lan and Xiaojian Wu

    Citation: BMC Cancer 2020 20:253

    Content type: Research article

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  31. Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection...

    Authors: Alexander R. Siebenhüner, Ulrich Güller and Rene Warschkow

    Citation: BMC Cancer 2020 20:246

    Content type: Research article

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  32. We performed a pooled analysis of the COMPARZ study assessing efficacy and safety of pazopanib versus sunitinib in treatment-naïve Chinese patients with locally advanced and/or metastatic renal cell carcinoma ...

    Authors: Xinan Sheng, Jie Jin, Zhisong He, Yiran Huang, Aiping Zhou, Jinwan Wang, Xiubao Ren, Dingwei Ye, Xu Zhang, Shukui Qin, Fangjian Zhou, Binhui Wang and Jun Guo

    Citation: BMC Cancer 2020 20:219

    Content type: Research article

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  33. Tumor budding (TB) is used as an indicator of poor prognosis in various cancers. However, studies on TB in perihilar cholangiocarcinoma are still limited. We examined the significance of TB in resected perihil...

    Authors: Takahiro Ito, Naohisa Kuriyama, Yuji Kozuka, Haruna Komatsubara, Ken Ichikawa, Daisuke Noguchi, Aoi Hayasaki, Tekehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai…

    Citation: BMC Cancer 2020 20:209

    Content type: Research article

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  34. The expression of vascular endothelial growth factor (VEGF)-A/ VAGF receptors (VEGFRs) signaling plays a pivotal role in the tumor angiogenesis and the development of the immunosuppressive tumor microenvironme...

    Authors: Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Tetsuro Hikichi, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida and Masahiro Toda

    Citation: BMC Cancer 2020 20:196

    Content type: Research article

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  35. After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surve...

    Authors: Xiaobin Zhang, Ben M. Eyck, Yang Yang, Jun Liu, Yin-Kai Chao, Ming-Mo Hou, Tsung-Min Hung, Qingsong Pang, Zhen-Tao Yu, Hongjing Jiang, Simon Law, Ian Wong, Ka-On Lam, Berend J. van der Wilk, Ate van der Gaast, Manon C. W. Spaander…

    Citation: BMC Cancer 2020 20:194

    Content type: Study protocol

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  36. Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in P...

    Authors: Yuanchao Liu, Yizeng Wang, Ke Zhao, Dongyang Li, Zuoyu Chen, Ruoyu Jiang, Xiaoning Wang and Xianghui He

    Citation: BMC Cancer 2020 20:181

    Content type: Database

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  37. Lung cancer is the major malignant tumour. The present study was conducted to determine the expression level of syntenin in lung cancer tissues and serum from lung cancer patients and to explore its clinical s...

    Authors: Pengyong Luo, Xuli Yang, Shiren Huang, Shu Feng and Zongxing Ou

    Citation: BMC Cancer 2020 20:159

    Content type: Research article

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  38. Despite recent advances in diagnosis and treatment, cervical cancer continues to be a significant health problem worldwide. Whereas robot-assisted surgery has advantages over the abdominal approach, and minima...

    Authors: Kyung Jin Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2020 20:152

    Content type: Research article

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  39. It remains controversial whether prophylactic No.10 lymph node clearance is necessary for gastric cancer. Thus, the present study aims to investigate the impact of prophylactic No.10 lymph node clearance on th...

    Authors: Gaozan Zheng, Jinqiang Liu, Yinghao Guo, Fei Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng

    Citation: BMC Cancer 2020 20:149

    Content type: Research article

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  40. Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, ...

    Authors: Yiran Cai, Hongbo Wu, Xiaoqin Shi, Yujie Dong, Xiujun Chang, Li Zhang, Lijuan Zhou, Dan Su and Ming Yang

    Citation: BMC Cancer 2020 20:148

    Content type: Research article

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  41. Thoracic epidural analgesia is the standard postoperative pain management strategy in esophageal cancer surgery. However, paravertebral block analgesia may achieve comparable pain control while inducing less s...

    Authors: B. F. Kingma, W. J. Eshuis, E. M. de Groot, M. L. Feenstra, J. P. Ruurda, S. S. Gisbertz, W. ten Hoope, M. Marsman, J. Hermanides, M. W. Hollmann, C. J. Kalkman, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, H. J. Scholten, M. Buise, M. J. van Det…

    Citation: BMC Cancer 2020 20:142

    Content type: Study protocol

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  42. Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development re...

    Authors: Marie C. Hupe, Lukas Dormayer, Tomasz Ozimek, Julian P. Struck, Martin J. P. Hennig, Melanie Klee, Christoph A. J. von Klot, Markus A. Kuczyk, Axel S. Merseburger and Mario W. Kramer

    Citation: BMC Cancer 2020 20:140

    Content type: Research article

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  43. Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing i...

    Authors: Ligia Craciun, Roland de Wind, Pieter Demetter, Valerio Lucidi, Ali Bohlok, Sébastien Michiels, Fikri Bouazza, Michael Vouche, Ilario Tancredi, Gontran Verset, Soizic Garaud, Céline Naveaux, Maria Gomez Galdon, Karen Willard Gallo, Alain Hendlisz, Ivan Duran Derijckere…

    Citation: BMC Cancer 2020 20:135

    Content type: Research article

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  44. Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Tr...

    Authors: Anthony C. Nichols, Pencilla Lang, Eitan Prisman, Eric Berthelet, Eric Tran, Sarah Hamilton, Jonn Wu, Kevin Fung, John R. de Almeida, Andrew Bayley, David P. Goldstein, Antoine Eskander, Zain Husain, Houda Bahig, Apostolos Christopoulous, Michael Hier…

    Citation: BMC Cancer 2020 20:125

    Content type: Study protocol

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  45. Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The caus...

    Authors: Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun and Kyoil Suh

    Citation: BMC Cancer 2020 20:118

    Content type: Research article

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