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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 15

  1. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao

    Citation: BMC Cancer 2020 20:1158

    Content type: Research article

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  2. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy

    Citation: BMC Cancer 2020 20:1147

    Content type: Research article

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  3. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang

    Citation: BMC Cancer 2020 20:1129

    Content type: Research article

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  4. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang

    Citation: BMC Cancer 2020 20:1120

    Content type: Research article

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  5. There is no currently available treatment for peritoneal metastasis of gastric cancer. This phase II study aimed to evaluate the efficacy and safety of neoadjuvant systemic chemotherapy and hyperthermic intrap...

    Authors: Pengfei Yu, Zeyao Ye, Gaiguo Dai, Yanqiang Zhang, Ling Huang, Yian Du and Xiangdong Cheng

    Citation: BMC Cancer 2020 20:1108

    Content type: Research article

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  6. Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a v...

    Authors: Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume and Gro Wiedswang

    Citation: BMC Cancer 2020 20:1107

    Content type: Research article

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  7. AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi and Fumio Imamura

    Citation: BMC Cancer 2020 20:1100

    Content type: Research article

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  8. The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of un...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi and Hiromasa Ohira

    Citation: BMC Cancer 2020 20:1094

    Content type: Research article

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  9. This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic sc...

    Authors: Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima and Yukihide Kanemitsu

    Citation: BMC Cancer 2020 20:1092

    Content type: Research article

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  10. This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.

    Authors: Feng Xu, Jian Song, Beizheng Xu, Jiang Wang, Jianjun Mao, Haiyan Liu, Xuanmei Li and Aibing Deng

    Citation: BMC Cancer 2020 20:1089

    Content type: Research article

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  11. For patients with multiple myeloma (MM), each additional line of therapy (LOT) is associated with lower response rates, shorter treatment duration and treatment-free intervals, and increased rates of toxicitie...

    Authors: Rafael Fonseca, Saad Z. Usmani, Maneesha Mehra, Mary Slavcev, Jianming He, Sarah Cote, Annette Lam, Jon Ukropec, Eric M. Maiese, Sandhya Nair, Ravi Potluri and Peter M. Voorhees

    Citation: BMC Cancer 2020 20:1087

    Content type: Research article

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  12. The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we enginee...

    Authors: Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy and Prabhas V. Moghe

    Citation: BMC Cancer 2020 20:1082

    Content type: Research article

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  13. The clinicopathological classification of breast cancer is proposed according to therapeutic purposes. It is simplified and can be conducted easily in clinical practice, and this subtyping undoubtedly contribu...

    Authors: Ming Ni, Xiaoming Zhou, Jingwei Liu, Haiyang Yu, Yuanxiang Gao, Xuexi Zhang and Zhiming Li

    Citation: BMC Cancer 2020 20:1073

    Content type: Research article

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  14. Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas and central neurocytomas. The treatment of choice is neurosurgica...

    Authors: A. Kaywan Aftahy, Melanie Barz, Philipp Krauss, Friederike Liesche, Benedikt Wiestler, Stephanie E. Combs, Christoph Straube, Bernhard Meyer and Jens Gempt

    Citation: BMC Cancer 2020 20:1060

    Content type: Research article

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  15. The effect of tumor size on account of long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff valu...

    Authors: Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang and Xiangcheng Li

    Citation: BMC Cancer 2020 20:1044

    Content type: Research article

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  16. Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of G...

    Authors: Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta and Sachio Fushida

    Citation: BMC Cancer 2020 20:1014

    Content type: Research article

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  17. Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of ...

    Authors: Gry Johansen, Pernilla Dahm-Kähler, Christian Staf, Angelique Flöter Rådestad and Kenny A. Rodriguez-Wallberg

    Citation: BMC Cancer 2020 20:1009

    Content type: Research article

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  18. Historically, amputation was the primary surgical treatment for osteosarcoma of the extremities; however, with advancements in surgical techniques and chemotherapies limb salvage has replaced amputation as the...

    Authors: Daniel R. Evans, Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer III, Brian E. Brigman and William C. Eward

    Citation: BMC Cancer 2020 20:995

    Content type: Research article

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  19. Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical ...

    Authors: Shuxin Sun, Chaobin He, Jun Wang, Xin Huang, Jiali Wu and Shengping Li

    Citation: BMC Cancer 2020 20:981

    Content type: Research article

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  20. Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. No comparative study of these tumors for the restric...

    Authors: Dongli Shi, Jun Sun, Liang Ma, Jing Chang and Hongjun Li

    Citation: BMC Cancer 2020 20:977

    Content type: Research article

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  21. Brain metastasis represents a major complication with a significantly shorter overall survival of many oncological diseases, in particular of lung cancer, breast cancer and malignant melanoma patients. However...

    Authors: Annalen Bleckmann, Benjamin Kirchner, Manuel Nietert, Micha Peeck, Marko Balkenhol, Daniela Egert, T. Veit Rohde, Tim Beißbarth and Tobias Pukrop

    Citation: BMC Cancer 2020 20:973

    Content type: Research article

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  22. Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2...

    Authors: Jian Wang, Yamin Zhang, Lei Liu, Zilin Cui, Rui Shi, Jiancun Hou, Zirong Liu, Long Yang, Lianjiang Wang and Yang Li

    Citation: BMC Cancer 2020 20:966

    Content type: Research article

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  23. The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The developme...

    Authors: Sihua Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong…

    Citation: BMC Cancer 2020 20:959

    Content type: Research article

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  24. For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. Howe...

    Authors: Shoko Ono, Ayako Nozaki, Kana Matsuda, Emi Takakuwa, Naoya Sakamoto and Hidemichi Watari

    Citation: BMC Cancer 2020 20:955

    Content type: Research article

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  25. Preoperative breast magnetic resonance imaging (MRI) provides more information than mammography and ultrasonography for determining the surgical plan for patients with breast cancer. This study aimed to determ...

    Authors: Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Chan Sub Park, Ryu Kyung Lee, Hye Jung Kim, Won Hwa Kim and Ho Yong Park

    Citation: BMC Cancer 2020 20:934

    Content type: Research article

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  26. Elastography is a promising way to evaluate tissue differences regarding stiffness, and the stiffness of the malignant breast lesions increased at the lesion margin. However, there is a lack of data on the val...

    Authors: Hui Yang, Yongyuan Xu, Yanan Zhao, Jing Yin, Zhiyi Chen and Pintong Huang

    Citation: BMC Cancer 2020 20:930

    Content type: Research article

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  27. A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (...

    Authors: Junichi Mazaki, Kenji Katsumata, Kenta Kasahara, Tomoya Tago, Takahiro Wada, Hiroshi Kuwabara, Masanobu Enomoto, Tetsuo Ishizaki, Yuichi Nagakawa and Akihiko Tsuchida

    Citation: BMC Cancer 2020 20:922

    Content type: Research article

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  28. In the management of operable hilar cholangiocarcinoma (HC) patients with hyperbilirubinemia, preoperative biliary drainage is a measure to bring down the bilirubin to a certain level so as to avoid adverse po...

    Authors: Wong Hoi She, Tan To Cheung, Ka Wing Ma, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan and Chung Mau Lo

    Citation: BMC Cancer 2020 20:914

    Content type: Research article

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  29. Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and me...

    Authors: Jia Huang, Guodong Chen, Huan Liu, Yiwei Zhang, Rong Tang, Qiulin Huang, Kai Fu, Xiuda Peng and Shuai Xiao

    Citation: BMC Cancer 2020 20:908

    Content type: Research article

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  30. Pancreatic neuroendocrine neoplasms (p-NENs) are a group of highly heterogeneous tumors with distinct clinicopathological features and long-term prognosis. In 2017, in order to better stratify patients into pr...

    Authors: Min Yang, Lin Zeng, Neng-wen Ke, Chun-lu Tan, Bo-le Tian, Xu-bao Liu, Bo Xiang and Yi Zhang

    Citation: BMC Cancer 2020 20:906

    Content type: Research article

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  31. Despite obvious advances over the last decades, locally advanced adenocarcinomas of the gastroesophageal junction (GEJ) still carry a dismal prognosis with overall 5-year survival rates of less than 50% even w...

    Authors: Sylvie Lorenzen, Alexander Biederstädt, Ulrich Ronellenfitsch, Christoph Reißfelder, Stefan Mönig, Frederik Wenz, Claudia Pauligk, Martin Walker, Salah-Eddin Al-Batran, Bernhard Haller and Ralf-Dieter Hofheinz

    Citation: BMC Cancer 2020 20:886

    Content type: Study protocol

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  32. Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The pur...

    Authors: Yusuke Shinoda, Eisuke Kobayashi, Hiroshi Kobayashi, Tomoaki Mori, Naofumi Asano, Robert Nakayama, Hideo Morioka, Shintaro Iwata, Tsukasa Yonemoto, Takeshi Ishii, Tohru Hiruma, Akira Kawai and Hirotaka Kawano

    Citation: BMC Cancer 2020 20:883

    Content type: Research article

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  33. Recent studies have shown that chemotherapy destabilizes the blood vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic cancer patients (Met-pa). CTCs are a precurso...

    Authors: Nerymar Ortiz-Otero, Jocelyn R. Marshall, Bradley Lash and Michael R. King

    Citation: BMC Cancer 2020 20:873

    Content type: Research article

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  34. The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy ...

    Authors: Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka and Hideki Murakami

    Citation: BMC Cancer 2020 20:868

    Content type: Research article

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  35. The aim of this study is to assess biplane transrectal ultrasonography (TRUS) plus ultrasonic elastosonography (UE) and contrast-enhanced ultrasonography (CEUS) in T staging of rectal cancer.

    Authors: Yanru Feng, Chanjuan Peng, Yuan Zhu and Luying Liu

    Citation: BMC Cancer 2020 20:862

    Content type: Research article

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  36. The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph n...

    Authors: Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu and Jianye Wang

    Citation: BMC Cancer 2020 20:851

    Content type: Research article

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  37. We aimed to identify which part of the patients with metastatic renal cell carcinoma (mRCC) is not suitable for cytoreductive nephrectomy (CN).

    Authors: Zhao Zhang, Hongliang Wu, Tong Yang, Yaohai Wu, Nengwang Yu and Zhonghua Xu

    Citation: BMC Cancer 2020 20:844

    Content type: Research article

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  38. Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in p...

    Authors: Takashi Okuyama, Shinichi Sameshima, Emiko Takeshita, Takashi Mitsui, Takuji Noro, Yuko Ono, Tamaki Noie, Shinichi Ban and Masatoshi Oya

    Citation: BMC Cancer 2020 20:842

    Content type: Research article

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  39. Existing imaging techniques have a low ability to detect lymph node metastasis (LNM) of gallbladder cancer (GBC). Gallbladder removal by laparoscopic cholecystectomy can provide pathological information regard...

    Authors: Yingnan Yang, Zhuolong Tu, Huajie Cai, Bingren Hu, Chentao Ye and Jinfu Tu

    Citation: BMC Cancer 2020 20:828

    Content type: Research article

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  40. Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favor...

    Authors: Dieter H. Heiland, Robin Ohle, Debora Cipriani, Pamela Franco, Daniel Delev, Simon P. Behriger, Elias Kellner, Gergana Petrova, Nicolas Neidert, Irina Mader, Mateo Fariña Nuñez, Horst Urbach, Roman Sankowski, Jürgen Beck and Oliver Schnell

    Citation: BMC Cancer 2020 20:818

    Content type: Research article

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  41. Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ ...

    Authors: Jing Zhao, Qiang Li, Merlin Muktiali, Bingjie Ren, Yingxi Hu, Dapeng Li, Zhi Li, Daoming Li, Yufeng Xie, Min Tao and Rongrui Liang

    Citation: BMC Cancer 2020 20:812

    Content type: Research article

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  42. This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in m...

    Authors: Xiling Yu, Xueke Li, Yue Xing, Siduo Lu, Silvia Tanumiharjo and Jin Ma

    Citation: BMC Cancer 2020 20:808

    Content type: Research article

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  43. The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications...

    Authors: Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao…

    Citation: BMC Cancer 2020 20:801

    Content type: Study protocol

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  44. The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of pulmonary tumors remained debatable among published studies. This study aimed t...

    Authors: Jianye Liang, Jing Li, Zhipeng Li, Tiebao Meng, Jieting Chen, Weimei Ma, Shen Chen, Xie Li, Yaopan Wu and Ni He

    Citation: BMC Cancer 2020 20:799

    Content type: Research article

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  45. Adenocarcinoma of the gastroesophageal junction (GEJ) Siewert type II can be resected by transthoracic esophagectomy or transhiatal extended gastrectomy. Both allow for a complete tumor resection, yet there is...

    Authors: Jessica M. Leers, Laura Knepper, Arjen van der Veen, Wolfgang Schröder, Hans Fuchs, Petra Schiller, Martin Hellmich, Ulrike Zettelmeyer, Lodewijk A. A. Brosens, Alexander Quaas, Jelle P. Ruurda, Richard van Hillegersberg and Christiane J. Bruns

    Citation: BMC Cancer 2020 20:781

    Content type: Study protocol

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  46. The influence of anastomotic leakage (AL) on local recurrence rates and survival in rectal cancer remains controversial. The aim of this study was to analyze the effect of asymptomatic anastomotic leakage (AAL...

    Authors: Alice Artus, Nicolas Tabchouri, Othman Iskander, Nicolas Michot, Olivier Muller, Urs Giger-Pabst, Pascal Bourlier, Céline Bourbao-Tournois, Aurore Kraemer-Bucur, Thierry Lecomte, Ephrem Salamé and Mehdi Ouaissi

    Citation: BMC Cancer 2020 20:780

    Content type: Research article

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  47. Gastric neoplasms containing neuroendocrine carcinoma (NEC) components are rare malignancies with highly aggressive behavior and a poor prognosis and include pure NEC and mixed tumors containing NEC components...

    Authors: Jiahui Chen, Anqiang Wang, Ke Ji, Zhaode Bu and Jiafu Ji

    Citation: BMC Cancer 2020 20:777

    Content type: Research article

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