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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 12

  1. The objective of the IMPROVE study was patients’ preference for either endocrine-based therapy or combined chemo- and anti-angiogenic therapy in advanced HR-positive/HER2-negative breast cancer.

    Authors: Thomas Decker, Ulrike Söling, Antje Hahn, Christoph Maintz, Christian Martin Kurbacher, Ursula Vehling-Kaiser, Dagmar Sent, Peter Klare, Volker Hagen, Marco Chiabudini, Julia Falkenstein, Martin Indorf, Eva Runkel and Karin Potthoff

    Citation: BMC Cancer 2020 20:286

    Content type: Research article

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  2. Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.

    Authors: Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi and Wansheng Long

    Citation: BMC Cancer 2020 20:274

    Content type: Research article

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  3. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco

    Citation: BMC Cancer 2020 20:271

    Content type: Case report

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  4. In the past four decades, the incidence of cholangiocarcinoma, especially intrahepatic cholangiocarcinoma (ICC), has raised rapidly worldwide. Completeness of resection, max size of tumor and etc. are widely r...

    Authors: Zeyu Zhang, Yufan Zhou, Kuan Hu, Dong Wang, Zhiming Wang and Yun Huang

    Citation: BMC Cancer 2020 20:270

    Content type: Research article

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  5. Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the fi...

    Authors: John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski and Naris Nilubol

    Citation: BMC Cancer 2020 20:256

    Content type: Case report

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  6. Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...

    Authors: Zerong Cai, Xiaoyu Xie, Yufeng Chen, Zexian Chen, Wuteng Cao, Khamis Salem Saeed Saad, Yifeng Zou, Ping Lan and Xiaojian Wu

    Citation: BMC Cancer 2020 20:253

    Content type: Research article

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  7. Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection...

    Authors: Alexander R. Siebenhüner, Ulrich Güller and Rene Warschkow

    Citation: BMC Cancer 2020 20:246

    Content type: Research article

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  8. We performed a pooled analysis of the COMPARZ study assessing efficacy and safety of pazopanib versus sunitinib in treatment-naïve Chinese patients with locally advanced and/or metastatic renal cell carcinoma ...

    Authors: Xinan Sheng, Jie Jin, Zhisong He, Yiran Huang, Aiping Zhou, Jinwan Wang, Xiubao Ren, Dingwei Ye, Xu Zhang, Shukui Qin, Fangjian Zhou, Binhui Wang and Jun Guo

    Citation: BMC Cancer 2020 20:219

    Content type: Research article

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  9. Tumor budding (TB) is used as an indicator of poor prognosis in various cancers. However, studies on TB in perihilar cholangiocarcinoma are still limited. We examined the significance of TB in resected perihil...

    Authors: Takahiro Ito, Naohisa Kuriyama, Yuji Kozuka, Haruna Komatsubara, Ken Ichikawa, Daisuke Noguchi, Aoi Hayasaki, Tekehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai…

    Citation: BMC Cancer 2020 20:209

    Content type: Research article

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  10. The expression of vascular endothelial growth factor (VEGF)-A/ VAGF receptors (VEGFRs) signaling plays a pivotal role in the tumor angiogenesis and the development of the immunosuppressive tumor microenvironme...

    Authors: Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida and Masahiro Toda

    Citation: BMC Cancer 2020 20:196

    Content type: Research article

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  11. After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surve...

    Authors: Xiaobin Zhang, Ben M. Eyck, Yang Yang, Jun Liu, Yin-Kai Chao, Ming-Mo Hou, Tsung-Min Hung, Qingsong Pang, Zhen-Tao Yu, Hongjing Jiang, Simon Law, Ian Wong, Ka-On Lam, Berend J. van der Wilk, Ate van der Gaast, Manon C. W. Spaander…

    Citation: BMC Cancer 2020 20:194

    Content type: Study protocol

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  12. Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in P...

    Authors: Yuanchao Liu, Yizeng Wang, Ke Zhao, Dongyang Li, Zuoyu Chen, Ruoyu Jiang, Xiaoning Wang and Xianghui He

    Citation: BMC Cancer 2020 20:181

    Content type: Database

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  13. Lung cancer is the major malignant tumour. The present study was conducted to determine the expression level of syntenin in lung cancer tissues and serum from lung cancer patients and to explore its clinical s...

    Authors: Pengyong Luo, Xuli Yang, Shiren Huang, Shu Feng and Zongxing Ou

    Citation: BMC Cancer 2020 20:159

    Content type: Research article

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  14. Despite recent advances in diagnosis and treatment, cervical cancer continues to be a significant health problem worldwide. Whereas robot-assisted surgery has advantages over the abdominal approach, and minima...

    Authors: Kyung Jin Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2020 20:152

    Content type: Research article

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  15. It remains controversial whether prophylactic No.10 lymph node clearance is necessary for gastric cancer. Thus, the present study aims to investigate the impact of prophylactic No.10 lymph node clearance on th...

    Authors: Gaozan Zheng, Jinqiang Liu, Yinghao Guo, Fei Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng

    Citation: BMC Cancer 2020 20:149

    Content type: Research article

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  16. Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, ...

    Authors: Yiran Cai, Hongbo Wu, Xiaoqin Shi, Yujie Dong, Xiujun Chang, Li Zhang, Lijuan Zhou, Dan Su and Ming Yang

    Citation: BMC Cancer 2020 20:148

    Content type: Research article

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  17. Thoracic epidural analgesia is the standard postoperative pain management strategy in esophageal cancer surgery. However, paravertebral block analgesia may achieve comparable pain control while inducing less s...

    Authors: B. F. Kingma, W. J. Eshuis, E. M. de Groot, M. L. Feenstra, J. P. Ruurda, S. S. Gisbertz, W. ten Hoope, M. Marsman, J. Hermanides, M. W. Hollmann, C. J. Kalkman, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, H. J. Scholten, M. Buise, M. J. van Det…

    Citation: BMC Cancer 2020 20:142

    Content type: Study protocol

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  18. Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development re...

    Authors: Marie C. Hupe, Lukas Dormayer, Tomasz Ozimek, Julian P. Struck, Martin J. P. Hennig, Melanie Klee, Christoph A. J. von Klot, Markus A. Kuczyk, Axel S. Merseburger and Mario W. Kramer

    Citation: BMC Cancer 2020 20:140

    Content type: Research article

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  19. Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing i...

    Authors: Ligia Craciun, Roland de Wind, Pieter Demetter, Valerio Lucidi, Ali Bohlok, Sébastien Michiels, Fikri Bouazza, Michael Vouche, Ilario Tancredi, Gontran Verset, Soizic Garaud, Céline Naveaux, Maria Gomez Galdon, Karen Willard Gallo, Alain Hendlisz, Ivan Duran Derijckere…

    Citation: BMC Cancer 2020 20:135

    Content type: Research article

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  20. Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Tr...

    Authors: Anthony C. Nichols, Pencilla Lang, Eitan Prisman, Eric Berthelet, Eric Tran, Sarah Hamilton, Jonn Wu, Kevin Fung, John R. de Almeida, Andrew Bayley, David P. Goldstein, Antoine Eskander, Zain Husain, Houda Bahig, Apostolos Christopoulous, Michael Hier…

    Citation: BMC Cancer 2020 20:125

    Content type: Study protocol

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  21. Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The caus...

    Authors: Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun and Kyoil Suh

    Citation: BMC Cancer 2020 20:118

    Content type: Research article

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  22. Invasive pancreatic neoplasms have a high propensity for recurrence even after curative resection. Recently, patients who underwent pancreatectomy have an opportunity of undergoing secondary pancreatic resecti...

    Authors: Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masaru Miyazaki and Masayuki Ohtsuka

    Citation: BMC Cancer 2020 20:111

    Content type: Research article

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  23. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is used in the palliative treatment of peritoneal metastasis. The combination of intraperitoneal and systemic chemotherapy seems rational, and the aim o...

    Authors: Magnus Ploug, Martin Graversen, Per Pfeiffer and Michael Bau Mortensen

    Citation: BMC Cancer 2020 20:105

    Content type: Research article

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  24. The purpose of this study was to investigate the value of wavelet-transformed radiomic MRI in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) for patients with locally adv...

    Authors: Jiali Zhou, Jinghui Lu, Chen Gao, Jingjing Zeng, Changyu Zhou, Xiaobo Lai, Wenli Cai and Maosheng Xu

    Citation: BMC Cancer 2020 20:100

    Content type: Research article

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  25. For selected locally advanced prostate cancer (PCa) patients, radical prostatectomy (RP) is one of the first-line treatments. We aimed to develop a preoperative nomogram to identify what kinds of patients can ...

    Authors: Xianghong Zhou, Qingyang Ning, Kun Jin, Tao Zhang and Xuelei Ma

    Citation: BMC Cancer 2020 20:97

    Content type: Research article

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  26. Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer.

    Authors: Ma-yi-di-li Ni-jia-ti, Di-li-a-re-mu Ai-hai-ti, Ai-si-ka-er-jiang Huo-jia, Pa-li-dan-mu Wu-mai-er, A-bu-du-ke-you-mu-jiang A-bu-li-zi, Yu Shi, Nu-er-a-mi-na Rou-zi, Wen-jing Su, Guo-zhao Dai and Mai-he-mi-ti-jiang Da-mo-la

    Citation: BMC Cancer 2020 20:94

    Content type: Research article

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  27. Although immediate breast reconstruction has been reported to be oncologically safe, no affirmative study comparing the two reconstruction methods exists. We investigated breast cancer recurrence rates in two ...

    Authors: Jeong Hyun Ha, Ki Yong Hong, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh, Joonho Lim, Sehoon Yoon, Hak Chang and Ung Sik Jin

    Citation: BMC Cancer 2020 20:78

    Content type: Research article

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  28. It is still difficult to detect and diagnose early adenocarcinoma of the esophagogastric junction (EGJ) using conventional endoscopy or image-enhanced endoscopy. A glutamylprolyl hydroxymethyl rhodamine green ...

    Authors: Keiko Yamamoto, Shunsuke Ohnishi, Takeshi Mizushima, Junichi Kodaira, Masayoshi Ono, Yutaka Hatanaka, Kanako C. Hatanaka, Yugo Kuriki, Mako Kamiya, Nobuyuki Ehira, Keisuke Shinada, Hiroaki Takahashi, Yuichi Shimizu, Yasuteru Urano and Naoya Sakamoto

    Citation: BMC Cancer 2020 20:64

    Content type: Research article

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  29. To explore the influencing factors of perioperative renal function change and their relationship with prognosis on renal cell carcinoma (RCC) patients with tumor thrombus after nephrectomy and thrombectomy.

    Authors: Zhuo Liu, Shiying Tang, Xiaojun Tian, Hongxian Zhang, Guoliang Wang, Shudong Zhang and Lulin Ma

    Citation: BMC Cancer 2020 20:61

    Content type: Research article

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  30. The value of the CT features and quantitative analysis of lung subsolid nodules (SSNs) in the prediction of the pathological grading of lung adenocarcinoma is discussed.

    Authors: Xiaohu Li, Wei Zhang, Yongqiang Yu, Guihong Zhang, Lifen Zhou, Zongshan Wu and Bin Liu

    Citation: BMC Cancer 2020 20:60

    Content type: Research article

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  31. This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer.

    Authors: Jia Gang Han, Zhen Jun Wang, Wei Gen Zeng, Yan Bin Wang, Guang Hui Wei, Zhi Wei Zhai, Bao Cheng Zhao and Bing Qiang Yi

    Citation: BMC Cancer 2020 20:57

    Content type: Research article

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  32. Hepatocellular carcinoma (HCC) with hilar bile duct tumor thrombus (HBDTT) often mimic hilar cholangiocarcinoma (hilar CC). The purpose of this study is to analyze the Computed Tomography (CT) characteristics ...

    Authors: Xiaoqi Zhou, Jifei Wang, Mimi Tang, Mengqi Huang, Ling Xu, Zhenpeng Peng, Zi-Ping Li and Shi-Ting Feng

    Citation: BMC Cancer 2020 20:54

    Content type: Research article

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  33. Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increa...

    Authors: Sven Lichthardt, Johanna Wagner, Stefan Löb, Niels Matthes, Caroline Kastner, Friedrich Anger, Christoph-Thomas Germer and Armin Wiegering

    Citation: BMC Cancer 2020 20:49

    Content type: Research article

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  34. The aim of this retrospective study was to compare the feasibility and efficiency of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by three-dimensional visualization ablation planning sy...

    Authors: Chao An, Xin Li, Min Zhang, Jian Yang, Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Linan Dong, Jie Yu and Ping Liang

    Citation: BMC Cancer 2020 20:44

    Content type: Research article

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  35. To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use.

    Authors: Ji Eun Park, Ho Sung Kim, Donghyun Kim, Seo Young Park, Jung Youn Kim, Se Jin Cho and Jeong Hoon Kim

    Citation: BMC Cancer 2020 20:29

    Content type: Research article

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  36. There is no comprehensive agreement concerning the overall performance of radical resection for T1b gallbladder cancer (GBC). This research focused on addressing whether T1b GBC may spread loco-regionally and ...

    Authors: Kizuki Yuza, Jun Sakata, Pankaj Prasoon, Yuki Hirose, Taku Ohashi, Koji Toge, Kohei Miura, Masayuki Nagahashi, Takashi Kobayashi and Toshifumi Wakai

    Citation: BMC Cancer 2020 20:20

    Content type: Research article

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  37. Adjuvant chemotherapy is relatively underused in older patients with colon cancer in Japan, and its age-specific effects on clinical outcomes remain unclear. This study aimed to assess the effect of adjuvant c...

    Authors: Hidetaka Kawamura, Toshitaka Morishima, Akira Sato, Michitaka Honda and Isao Miyashiro

    Citation: BMC Cancer 2020 20:19

    Content type: Research article

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  38. Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with genera...

    Authors: Yi Yu, Qunshan Wang, Jian Sun, Jing Zhao, Suyun Chen and Yigang Li

    Citation: BMC Cancer 2020 20:13

    Content type: Case report

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  39. We sought to investigate the prognostic value of complete blood count (CBC)-based biomarkers for patients with resectable gastric cancer (GC).

    Authors: Jian-Xian Lin, Jun-Peng Lin, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin, Ruhong Tu, Chao-Hui Zheng, Chang-Ming Huang and Ping Li

    Citation: BMC Cancer 2020 20:11

    Content type: Research article

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  40. Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A significant prognostic nomogram for predicting the respective disease-specific surviva...

    Authors: Chao-Yang Wang, Jin Yang, Hao Zi, Zhong-Li Zheng, Bing-Hui Li, Yang Wang, Zheng Ge, Guang-Xu Jian, Jun Lyu, Xiao-Dong Li and Xue-Qun Ren

    Citation: BMC Cancer 2020 20:10

    Content type: Research article

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  41. Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the...

    Authors: Chu-Wen Fang, Jyh-Seng Wang, Tony T. Wu and Jen-Tai Lin

    Citation: BMC Cancer 2019 19:1265

    Content type: Case report

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  42. To date, patients with metastasized pancreatic ductal adenocarcinoma (PDAC M1) are regarded as a uniform collective. We hypothesize the existence of oligometastatic disease (OMD): a state of PDAC M1 disease wi...

    Authors: Alexander I. Damanakis, Luisa Ostertag, Dirk Waldschmidt, Fabian Kütting, Alexander Quaas, Patrick Plum, Christiane J. Bruns, Florian Gebauer and Felix Popp

    Citation: BMC Cancer 2019 19:1261

    Content type: Research article

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  43. The application of multiparametric magnetic resonance imaging (mpMRI) for diagnosis of prostate cancer has been recommended by the European Association of Urology (EAU), National Comprehensive Cancer Network (...

    Authors: Liang Zhen, Xiaoqiang Liu, Chen Yegang, Yang Yongjiao, Xu Yawei, Kang Jiaqi, Wang Xianhao, Song Yuxuan, Hu Rui, Zhang Wei and Ou Ningjing

    Citation: BMC Cancer 2019 19:1244

    Content type: Research article

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  44. The aim of this study was to investigate how much the risks of recurrence and death are increased as a consequence of selecting fertility-sparing surgery (FSS) in young women with epithelial ovarian cancer (EOC).

    Authors: Hiroaki Kajiyama, Shiro Suzuki, Nobuhisa Yoshikawa, Michiyasu Kawai, Kimio Mizuno, Osamu Yamamuro, Tetsuro Nagasaka, Kiyosumi Shibata and Fumitaka Kikkawa

    Citation: BMC Cancer 2019 19:1235

    Content type: Research article

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  45. Neoadjuvant chemoradiotherapy is regarded as the standard of treatment for locally advanced lower rectal cancer, although some of these cases are systemic, and distant control may be inadequate. Neoadjuvant ch...

    Authors: Takuya Shiraishi, Takeshi Sasaki, Koji Ikeda, Yuichiro Tsukada, Yuji Nishizawa and Masaaki Ito

    Citation: BMC Cancer 2019 19:1222

    Content type: Research article

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  46. The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not compl...

    Authors: Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldarti, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore…

    Citation: BMC Cancer 2019 19:1215

    Content type: Study protocol

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    The Correction to this article has been published in BMC Cancer 2020 20:128

  47. We aimed to estimate the stage-specific impact of lymph node dissection (LND) on survival for upper urinary tract urothelial carcinoma (UTUC) patients treated with nephroureterectomy (NU).

    Authors: Ting-Shuai Zhai, Liang Jin, Zhen Zhou, Xiang Liu, Huan Liu, Wei Chen, Jing-Yi Lu, Xu-Dong Yao, Li-Ming Feng and Lin Ye

    Citation: BMC Cancer 2019 19:1207

    Content type: Research article

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