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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 11

  1. Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that c...

    Authors: Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini and Umberto Sabatini

    Citation: BMC Cancer 2019 19:1197

    Content type: Case report

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  2. An extremely rare condition, radiation-induced angiosarcoma is characterized by a poor prognosis, high recurrence rate and lack of effective treatment. Herein, we present a case report of a 48-year-old female ...

    Authors: Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie and Lizhu Lin

    Citation: BMC Cancer 2019 19:1188

    Content type: Case report

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  3. Precise staging is indispensable to select the appropriate treatment strategy for gastric cancer (GC); however, the diagnostic accuracy of conventional modalities needs to be improved. This study investigated ...

    Authors: Toshiyuki Kosuga, Tomoki Konishi, Takeshi Kubota, Katsutoshi Shoda, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Michihiro Kudou, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi and Eigo Otsuji

    Citation: BMC Cancer 2019 19:1187

    Content type: Research article

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  4. Several multicenter randomized controlled trials comparing laparoscopy and conventional open surgery for colon cancer have demonstrated that laparoscopic approach achieved the same oncological results while im...

    Authors: Gilles Manceau, Antoine Brouquet, Pascal Chaibi, Guillaume Passot, Olivier Bouché, Murielle Mathonnet, Jean-Marc Regimbeau, Rea Lo Dico, Jérémie H. Lefèvre, Frédérique Peschaud, Olivier Facy, Enrico Volpin, Elie Chouillard, Laura Beyert-Berjot, Marc Verny, Mehdi Karoui…

    Citation: BMC Cancer 2019 19:1185

    Content type: Study protocol

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  5. Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumour. Due to a high tumour recurrence rate, the post-operative overall survival (OS) and disease-free survival (DFS) of ACCs is limited. Our resea...

    Authors: Jiayu Liang, Zhihong Liu, Xin Wei, Liang Zhou, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu and Yuchun Zhu

    Citation: BMC Cancer 2019 19:1165

    Content type: Research article

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  6. To compare the efficacy and safety between conventional transarterial chemoembolization (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with infiltrative hepatocellular carcinoma (iHCC).

    Authors: Zi-shu Zhang, Hui-zhou Li, Cong Ma and Yu-dong Xiao

    Citation: BMC Cancer 2019 19:1162

    Content type: Research article

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  7. Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor. Although lymph node metastasis has been reported, it is still considered benign. No malignant transformation has been reported. This is the first...

    Authors: Xiao Teng and Xiaodong Teng

    Citation: BMC Cancer 2019 19:1154

    Content type: Case report

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  8. Conventional cystoscopy can detect advanced stages of bladder cancer; however, it has limitations to detect bladder cancer at the early stages. Fluorocoxib A, a rhodamine-conjugated analog of indomethacin, is ...

    Authors: Jennifer Bourn, Kusum Rathore, Robert Donnell, Wesley White, Md. Jashim Uddin, Lawrence Marnett and Maria Cekanova

    Citation: BMC Cancer 2019 19:1152

    Content type: Research article

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  9. Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpo...

    Authors: Hans-Jonas Meyer, Wolfram Pönisch, Stefan Andreas Schmidt, Susanne Wienbeck, Friederike Braulke, Dominik Schramm and Alexey Surov

    Citation: BMC Cancer 2019 19:1150

    Content type: Research article

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  10. Neurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is...

    Authors: Pierre R. Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan and Carlos Torres

    Citation: BMC Cancer 2019 19:1149

    Content type: Case report

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  11. To evaluate the clinicopathological and prognostic significance of the percentage change between maximum standardized uptake value (SUVmax) at 60 min (SUVmax1) and SUVmax at 120 min (SUVmax2) (ΔSUVmax%) using dua...

    Authors: Yoji YAMAGISHI, Tomomi KOIWAI, Tamio YAMASAKI, Takahiro EINAMA, Makiko FUKUMURA, Miyuki HIRATSUKA, Takako KONO, Katsumi HAYASHI, Jiro ISHIDA, Hideki UENO and Hitoshi TSUDA

    Citation: BMC Cancer 2019 19:1146

    Content type: Research article

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  12. Recent studies have found that inflammatory response is involved in the pathogenesis of ovarian cancer. Advanced ovarian cancer is often presented with ascites that is rich in cytokines, inflammatory factors o...

    Authors: Jun Shi, Rongfen Huo, Ningli Li, Haichuan Li, Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu and Wen Di

    Citation: BMC Cancer 2019 19:1140

    Content type: Research article

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  13. Thyroid nodules are frequently detected by cervical ultrasound examinations. In follow-up studies, malignant as well as benign nodules may exhibit an increase in size.

    Authors: Michael Cordes, Theresa Ida Götz, Karen Horstrup, Torsten Kuwert and Christian Schmidkonz

    Citation: BMC Cancer 2019 19:1139

    Content type: Research article

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  14. Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of po...

    Authors: Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Lidan Lin, Zhou Shao, Haijun Guo, Haiyang Xie, Lin Zhou, Shusen Zheng and Xiao Xu

    Citation: BMC Cancer 2019 19:1136

    Content type: Research article

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  15. Post-transplant lymphoproliferative disorders (PTLDs) represent a spectrum of heterogenetic lymphoid proliferations. PTLD is a serious complication that affects the long-term survival of kidney transplant pati...

    Authors: Jian-Chao Zhang, Hui-Xia Lan, Hui-Juan Zhao, Yang-Yang Lei, Li Ma, Xiao-Yan Xie, Ming-de Lu and Wei Wang

    Citation: BMC Cancer 2019 19:1135

    Content type: Case report

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  16. Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...

    Authors: Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke and Johanna W. Wilmink

    Citation: BMC Cancer 2019 19:1133

    Content type: Study protocol

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  17. TAE-gene therapy for hepatoma, incorporating the tumor-targeted therapeutic efficacy of trans-arterial embolization, hydroxyapatite nanoparticles (nHAP) and anti-cancer wild-type p53 gene (wt-p53), was present...

    Authors: Gaopeng Li, Wenqin Kang, Mingliang Jin, Lidong Zhang, Jian Zheng, Kai Jia, Jinfeng Ma, Ting Liu, Xueyi Dang, Zhifeng Yan, Zefeng Gao and Jun Xu

    Citation: BMC Cancer 2019 19:1126

    Content type: Research article

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  18. Intracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literat...

    Authors: Marc Prablek, Visish M. Srinivasan, Aditya Srivatsan, Stephanie Holdener, Mazen Oneissi, Kent A. Heck, Ali Jalali, Jacob Mandel, Ashwin Viswanathan and Akash J. Patel

    Citation: BMC Cancer 2019 19:1119

    Content type: Case report

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  19. Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition affecting multiple endocrine organs, resulting in significant morbidity and decreased life expectancy. Early tumor id...

    Authors: Lei Lou, Lixia Zhou, Wenyan Wang, Huina Li and Yuehong Li

    Citation: BMC Cancer 2019 19:1107

    Content type: Case report

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  20. The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambigu...

    Authors: A. Santoro, A. Piermattei, F. Inzani, G. Angelico, M. Valente, D. Arciuolo, S. Spadola, M. Martini, F. Fanfani, A. Fagotti, V. Gallotta, G. Scambia and G. F. Zannoni

    Citation: BMC Cancer 2019 19:1096

    Content type: Research article

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  21. We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer.

    Authors: Hyeong Min Park, Sang-Jae Park, Sung-Sik Han and Seoung Hoon Kim

    Citation: BMC Cancer 2019 19:1090

    Content type: Research article

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  22. High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks an...

    Authors: Xuefei Wang, Junjie Zhao, Mark Fairweather, Tingsong Yang, Yihong Sun and Jiping Wang

    Citation: BMC Cancer 2019 19:1079

    Content type: Research article

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  23. Increase of circulating tumor cells (CTCs) has been found after surgery for various carcinomas but not confirmed for breast cancer, and whether endoscopic surgery confers identical effect to CTCs as open surge...

    Authors: Shichao Li, Wenting Yan, Xinhua Yang, Li Chen, Linjun Fan, Haoxi Liu, Kun Liu, Yi Zhang and Jun Jiang

    Citation: BMC Cancer 2019 19:1070

    Content type: Research article

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  24. The computed tomography (CT) features of small solid lung cancers and their changing regularity as they grow have not been well studied. The purpose of this study was to analyze the CT features of solid lung c...

    Authors: Zhi-gang Chu, Yan Zhang, Wang-jia Li, Qi Li, Yi-neng Zheng and Fa-jin Lv

    Citation: BMC Cancer 2019 19:1060

    Content type: Research article

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  25. Most lymph node metastasis (LNM) models for early gastric cancer (EGC) include lymphovascular invasion (LVI) as a predictor. However, LVI must be confirmed by postoperative pathology. In this study, we aimed t...

    Authors: Jian-Xian Lin, Zu-Kai Wang, Wei Wang, Jacopo Desiderio, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Amilcare Parisi, Zhi-Wei Zhou and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:1048

    Content type: Research article

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  26. The application of laparoscopic liver resection (LLR) has expanded rapidly in recent decades. Although multiple authors have reported LLR shows improved safety and efficacy in treating hepatocellular carcinoma...

    Authors: Zi-Yu Wang, Qing-Lian Chen, Ling-Ling Sun, Shu-Ping He, Xiao-Fen Luo, Li-Shuang Huang, Jun-Hai Huang, Cheng-Ming Xiong and Chong Zhong

    Citation: BMC Cancer 2019 19:1047

    Content type: Research article

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  27. Assessment of preoperative general condition to predict postoperative outcomes is important, particularly in older patients who typically suffer from various comorbidities and exhibit impaired functional statu...

    Authors: Yuka Ahiko, Dai Shida, Tomoko Horie, Taro Tanabe, Yasuyuki Takamizawa, Ryohei Sakamoto, Konosuke Moritani, Shunsuke Tsukamoto and Yukihide Kanemitsu

    Citation: BMC Cancer 2019 19:946

    Content type: Research article

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  28. Radiological imaging plays a central role in the diagnosis of breast cancer (BC). Some studies suggest MRI techniques like diffusion weighted imaging (DWI) may provide further prognostic value by discriminatin...

    Authors: Alexey Surov, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C. Partridge, Jin You Kim and Andreas Wienke

    Citation: BMC Cancer 2019 19:1043

    Content type: Research article

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  29. The ultimate goal of locoregional therapy (LRT) to the liver is to induce total tumor necrosis. Trans-arterial chemoembolization (TACE) is the mainstay bridging therapy for patients with hepatocellular carcino...

    Authors: Wei Zhang, An-Hui Xu, Wei Wang, Yan-Hui Wu, Qian-Ling Sun and Chang Shu

    Citation: BMC Cancer 2019 19:1041

    Content type: Research article

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  30. Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available...

    Authors: Amine Souadka, Mohammed Anass Majbar, Amine Benkabbou, Badr Serji, Tarik Souiki, Sidi Mohammed Bouchentouf, Mourad Abid, Basma El Khannousi, Tijani El Harroudi, Hadj Omar El Malki, Mohammed Raiss, Lahsen Ifrine, Khalid Mazaz, Aziz Zentar, Raouf Mohsine, Abdelilah Souadka…

    Citation: BMC Cancer 2019 19:1008

    Content type: Research article

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  31. Amputation is the standard of care even for early-stage subungual melanomas (SUMs), known as nail apparatus melanoma, because the nail bed and nail matrix are close to the distal phalanx. However, a recent stu...

    Authors: Kiyo Tanaka, Yasuhiro Nakamura, Tomonori Mizutani, Taro Shibata, Arata Tsutsumida, Haruhiko Fukuda, Shigeto Matsushita, Megumi Aoki, Kenjiro Namikawa, Shuichi Ohe, Satoshi Fukushima and Naoya Yamazaki

    Citation: BMC Cancer 2019 19:1002

    Content type: Study protocol

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  32. Overexpression of epidermal growth factor receptor (EGFR) has been established as a valid therapeutic target of non-small cell lung cancer (NSCLC). However, the clinical benefit of cetuximab as an EGFR-targeti...

    Authors: Aiko Yamaguchi, Arifudin Achmad, Hirofumi Hanaoka, Yusri Dwi Heryanto, Anu Bhattarai, Ratianto, Erdene Khongorzul, Rini Shintawati, A. Adhipatria P. Kartamihardja, Ayaka Kanai, Yumi Sugo, Noriko S. Ishioka, Tetsuya Higuchi and Yoshito Tsushima

    Citation: BMC Cancer 2019 19:1000

    Content type: Research article

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  33. To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial...

    Authors: Yanan Lu, Ling Ma, Jianjun Qin, Zhaoqi Wang, Jia Guo, Yan Zhao, Hongkai Zhang, Xu Yan, Hui Liu, Hailiang Li, Ihab R. Kamel and Jinrong Qu

    Citation: BMC Cancer 2019 19:999

    Content type: Research article

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  34. Limited evidence is available regarding the dissemination of tumor tissues due to compression during massage therapy, a routine procedure in patients with various symptoms in Asian countries.

    Authors: Shinji Miwa, Michi Kamei, Satoru Yoshida, Satoshi Yamada, Hisaki Aiba, Hiroyuki Tsuchiya and Takanobu Otsuka

    Citation: BMC Cancer 2019 19:993

    Content type: Case report

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  35. Laparoscopic surgery, fast-track perioperative treatment and XELOX chemotherapy are effective strategies for shortening the duration of hospital stay for cancer patients. This trial aimed to clarify the safety...

    Authors: Jun Li, Xiang-Xing Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang, Gen-Hai Li, Xiao-Jiang Ying, Xiao-Yu Dai, Min Lu, Kai Jiang, Dong-Liang Fu, Xin-Lin Li, Jin-Jie He, Jian-Wei Wang, Li-Feng Sun, Dong Xu…

    Citation: BMC Cancer 2019 19:988

    Content type: Research article

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  36. Breast cancer related lymphoedema (BCRL) is a common side effect of cancer treatment. Recently indocyanine green (ICG) fluorescent lymphography has become a popular method for imaging the lymphatics, however t...

    Authors: Hiroo Suami, Asha Heydon-White, Helen Mackie, Sharon Czerniec, Louise Koelmeyer and John Boyages

    Citation: BMC Cancer 2019 19:985

    Content type: Technical advance

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  37. To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereaft...

    Authors: Yanqiao Ren, Yanyan Cao, Hong Ma, Xuefeng Kan, Chen Zhou, Jiacheng Liu, Qin Shi, Gansheng Feng, Bin Xiong and Chuansheng Zheng

    Citation: BMC Cancer 2019 19:983

    Content type: Research article

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  38. To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal adenocarcinoma based on the new 8...

    Authors: Weiwei Sheng, Ming Dong, Guosen Wang, Xiaoyang Shi, Wei Gao, Kewei Wang, He Song, Gang Shi and Xiaodong Tan

    Citation: BMC Cancer 2019 19:981

    Content type: Research article

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  39. One critical step in the therapy of patients with localized pancreatic cancer is the determination of local resectability. The decision between primary surgery versus upfront local or systemic cancer therapy s...

    Authors: U. A. Wittel, D. Lubgan, M. Ghadimi, O. Belyaev, W. Uhl, W. O. Bechstein, R. Grützmann, W. M. Hohenberger, A. Schmid, L. Jacobasch, R. S. Croner, A. Reinacher-Schick, U. T. Hopt, A. Pirkl, H. Oettle, R. Fietkau…

    Citation: BMC Cancer 2019 19:979

    Content type: Research article

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  40. The aim of this study is to present and evaluate surgical resection and reconstructive techniques using autologous femoral head bone-grafting in treating partial acetabular defects arising from primary pelvic ...

    Authors: Wei Sun, Pengfei Zan, Xiaojun Ma, Yingqi Hua, Jiakang Shen and Zhengdong Cai

    Citation: BMC Cancer 2019 19:969

    Content type: Research article

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  41. Lymphoma and dysplasia are rare complications of long-standing Crohn’s disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a ...

    Authors: Amal Bennani, Ghizlane Kharrasse, Miry Achraf, Khanoussi Wafa, Ismaili Zahi, Kamaoui Imane and Bouziane Mohamed

    Citation: BMC Cancer 2019 19:966

    Content type: Case report

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  42. 99mTc-Rituximab is a new specific radiopharmaceutical that binds to the CD20 receptor which is highly expressed on the surface of B cells. We conducted a study in which 99mTc-Rituximab was compared with filtered

    Authors: Jing-Jie Zhang, Wan-Chun Zhang, Cai-Xia An, Xiao-Min Li and Le Ma

    Citation: BMC Cancer 2019 19:956

    Content type: Research article

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  43. Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node rati...

    Authors: Min Su You, Sang Hyub Lee, Young Hoon Choi, Bang-sup Shin, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Dong Kee Jang, Jun Kyu Lee, Wooil Kwon, Jin-Young Jang and Sun-Whe Kim

    Citation: BMC Cancer 2019 19:952

    Content type: Research article

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  44. Biliary rhabdomyosarcoma (RMS) is the most common biliary tumor in children. The management of affected patients contains unique challenges because of the rarity of this tumor entity and its critical location ...

    Authors: Cristian Urla, Steven W. Warmann, Monika Sparber-Sauer, Andreas Schuck, Ivo Leuschner, Thomas Klingebiel, Gunnar Blumenstock, Guido Seitz, Ewa Koscielniak and Jörg Fuchs

    Citation: BMC Cancer 2019 19:945

    Content type: Research article

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