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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 17

  1. Trial on five plasma biomarkers (CA125, HE4, OPN, leptin, prolactin) and their possible role in differentiating benign from malignant ovarian tumors.

    Authors: A. Hasenburg, D. Eichkorn, F. Vosshagen, E. Obermayr, A. Geroldinger, R. Zeillinger and M. Bossart

    Citation: BMC Cancer 2021 21:1037

    Content type: Research article

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  2. There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachythera...

    Authors: Duo Hong, Yi Zhou, Xiaoting Wan, Hongying Su and Haibo Shao

    Citation: BMC Cancer 2021 21:1020

    Content type: Research article

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  3. OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and be...

    Authors: N. Mikic, F. R. Poulsen, K. B. Kristoffersen, R. J. Laursen, T. L. Guldberg, J. Skjøth-Rasmussen, E. T. Wong, S. Møller, R. H. Dahlrot, J. C. H. Sørensen and A. R. Korshøj

    Citation: BMC Cancer 2021 21:1010

    Content type: Study protocol

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  4. In clinical studies, it has been observed that esophageal cancer (EC) patient prognosis can be very different even for those patients with tumors of the same TNM stage. Tumor length has been analysed as a poss...

    Authors: Zhao Yang Wang, Yuan Zhu Jiang, Wen Xiao, Xian Biao Xue, Xiang Wei Zhang and Lin Zhang

    Citation: BMC Cancer 2021 21:988

    Content type: Research article

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  5. The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a+ DCs have been rep...

    Authors: Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi and Shinichi Aishima

    Citation: BMC Cancer 2021 21:973

    Content type: Research article

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  6. Photodynamic therapy with a photosensitizer such as protoporphyrin-IX, a light sensitive metabolite of heme synthesis, is a highly selective treatment for various carcinomas. In previous studies, we found a si...

    Authors: Bernhard Gillissen, Antje Richter, Frank Essmann and Wolfgang Kemmner

    Citation: BMC Cancer 2021 21:971

    Content type: Research article

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  7. The advent of immune checkpoint inhibitors (ICIs) therapy has resulted in significant survival benefits in patients with non-small-cell lung cancer (NSCLC) without increasing toxicity. However, the utilisation...

    Authors: Chengdi Wang, Jingwei Li, Qiran Zhang, Jiayang Wu, Yuxuan Xiao, Lujia Song, Hanlin Gong and Yalun Li

    Citation: BMC Cancer 2021 21:968

    Content type: Research article

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  8. Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a poor prognosis. Given the limited treatment options, prognostic assessment of ACC is increasingly crucial. In this study, we aim to ass...

    Authors: Fuxun Zhang, Zhihong Liu, Jiayu Liang, Shengzhuo Liu, Kan Wu, Fan Zhang, Chuan Zhou, Yiping Lu, Yuchun Zhu and Xianding Wang

    Citation: BMC Cancer 2021 21:961

    Content type: Research article

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  9. In patients with average risk of bleeding, second-look endoscopy does not reportedly reduce bleeding after gastric endoscopic submucosal dissection. However, effectiveness of second-look endoscopy for patients...

    Authors: Takeshi Uozumi, Tetsuya Sumiyoshi, Yusuke Tomita, Kaho Tokuchi, Hiroya Sakano, Masahiro Yoshida, Ryoji Fujii, Takeyoshi Minagawa, Yutaka Okagawa, Kotaro Morita, Kei Yane, Hideyuki Ihara, Michiaki Hirayama and Hitoshi Kondo

    Citation: BMC Cancer 2021 21:946

    Content type: Research article

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  10. Among patients with non-metastatic pancreatic cancer, 80% have high-risk, borderline resectable or locally advanced cancer, with a 5-year overall survival of 12%. MASTERPLAN evaluates the safety and activity o...

    Authors: Andrew Oar, Mark Lee, Hien Le, Kate Wilson, Chris Aiken, Lorraine Chantrill, John Simes, Nam Nguyen, Andrew Barbour, Jaswinder Samra, Katrin M. Sjoquist, Alisha Moore, David Espinoza, Val Gebski, Sonia Yip, Julie Chu…

    Citation: BMC Cancer 2021 21:936

    Content type: Study protocol

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  11. Total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiotherapy (RT) are standard treatment for lower cT3/4 rectal cancers in Eastern countries. In comparative studies, both TME +...

    Authors: Masayoshi Yasui, Masayuki Ohue, Shingo Noura, Norikatsu Miyoshi, Yusuke Takahashi, Chu Matsuda, Junichi Nishimura, Naotsugu Haraguchi, Hajime Ushigome, Nozomu Nakai, Shiki Fujino, Keijiro Sugimura, Hiroshi Wada, Hidenori Takahashi, Takeshi Omori and Hiroshi Miyata

    Citation: BMC Cancer 2021 21:911

    Content type: Research article

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  12. This study aimed to assess the utility of deep learning analysis using pretreatment FDG-PET images to predict local treatment outcome in oropharyngeal squamous cell carcinoma (OPSCC) patients.

    Authors: Noriyuki Fujima, V. Carlota Andreu-Arasa, Sara K. Meibom, Gustavo A. Mercier, Minh Tam Truong, Kenji Hirata, Koichi Yasuda, Satoshi Kano, Akihiro Homma, Kohsuke Kudo and Osamu Sakai

    Citation: BMC Cancer 2021 21:900

    Content type: Research article

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  13. Radical surgery is the first line treatment for localized prostate cancer (PC), however, several studies have demonstrated that surgical procedures induce tumor cell mobilization from the primary tumor into th...

    Authors: Nerymar Ortiz-Otero, Jocelyn R. Marshall, Antonio Glenn, Jubin Matloubieh, Jean Joseph, Deepak M. Sahasrabudhe, Edward M. Messing and Michael R. King

    Citation: BMC Cancer 2021 21:898

    Content type: Research article

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  14. Patterns of failure after treatment of oral and squamous cell carcinomas (OSCC) are diversified, with recurrences being one of the common causes. A special group of patients are sometimes encountered in the ou...

    Authors: Yue He, Zhonglong Liu, Surui Sheng, Weijin Gao, Xiao Tang, Xiaoguang Li and Chunyue Ma

    Citation: BMC Cancer 2021 21:878

    Content type: Research article

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  15. This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy and long-term maintenance therapy with temo...

    Authors: Kenichiro Asano, Toshio Fumoto, Masashi Matsuzaka, Seiko Hasegawa, Naoya Suzuki, Kenichi Akasaka, Kosuke Katayama, Akihisa Kamataki, Akira Kurose and Hiroki Ohkuma

    Citation: BMC Cancer 2021 21:867

    Content type: Research article

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  16. Lymphovascular space invasion is an independent prognostic factor in early-stage cervical cancer. However, there is a lack of non-invasive methods to detect lymphovascular space invasion. Some researchers foun...

    Authors: Xiaoran Li, Chen Xu, Yang Yu, Yan Guo and Hongzan Sun

    Citation: BMC Cancer 2021 21:866

    Content type: Research article

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  17. Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However...

    Authors: Angeline Ginzac, Guillaume Dupic, Lucie Brun, Ioana Molnar, Mélanie Casile, Xavier Durando, Pierre Verrelle, Jean-Jacques Lemaire, Toufic Khalil and Julian Biau

    Citation: BMC Cancer 2021 21:864

    Content type: Study protocol

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  18. Primary urethral carcinoma (PUC) is a rare genitourinary malignancy with a relatively poor prognosis. The aim of this study was to examine the impact of surgery on survival of patients diagnosed with PUC.

    Authors: Jie Wu, Yu-Chen Wang, Wen-Jie Luo, Bo-Dai, Ding-Wei Ye and Yi-Ping Zhu

    Citation: BMC Cancer 2021 21:857

    Content type: Research article

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  19. Irreversible electroporation (IRE) is a local ablation technique utilizing high voltage, low energy direct current to create nanopores in cell membrane which disrupt homeostasis and leads to cell death. Previo...

    Authors: Govindarajan Narayanan, Malcolm M. Bilimoria, Peter J. Hosein, Zhaohui Su, Kathleen M. Mortimer and Robert C. G. Martin II

    Citation: BMC Cancer 2021 21:785

    Content type: Study protocol

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  20. Synovial sarcoma is an aggressive but chemosensitive soft-tissue tumor. We retrospectively analyzed the efficacy of perioperative chemotherapy for synovial sarcoma with data from the nationwide database, Bone ...

    Authors: Gang Xu, Hisaki Aiba, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Shiro Saito, Kenichi Yoshimura, Hideki Murakami, Hiroyuki Tsuchiya and Akira Kawai

    Citation: BMC Cancer 2021 21:773

    Content type: Research article

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  21. Due to negative results in clinical trials of postoperative chemoradiation for gastric cancer, at present, there is a tendency to move chemoradiation therapy forward in gastric and gastroesophageal junction (G...

    Authors: Yu-Jie Zhou, Xiao-Fan Lu, Jia-Lin Meng, Xin-Yuan Wang, Qing-Wei Zhang, Jin-Nan Chen, Qi-Wen Wang, Fang-Rong Yan and Xiao-Bo Li

    Citation: BMC Cancer 2021 21:771

    Content type: Research article

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  22. The surgical management and outcomes of renal cell carcinoma (RCC) with venous tumor thrombus (VTT) have been reported in limited sample size, and there remain discrepancies over the factors that influence onc...

    Authors: Zhigang Chen, Feilong Yang, Liyuan Ge, Min Qiu, Zhuo Liu, Cheng Liu, Xiaojun Tian, Shudong Zhang and Lulin Ma

    Citation: BMC Cancer 2021 21:766

    Content type: Research article

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  23. Corticosteroid therapy (CST) prior to biopsy may hinder histopathological diagnosis in primary central nervous system lymphoma (PCNSL). Therefore, preoperative CST in patients with suspected PCNSL should be av...

    Authors: Florian Scheichel, Franz Marhold, Daniel Pinggera, Barbara Kiesel, Tobias Rossmann, Branko Popadic, Adelheid Woehrer, Michael Weber, Melitta Kitzwoegerer, Klaus Geissler, Astrid Dopita, Stefan Oberndorfer, Wolfgang Pfisterer, Christian F. Freyschlag, Georg Widhalm, Karl Ungersboeck…

    Citation: BMC Cancer 2021 21:754

    Content type: Research article

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  24. Radiofrequency ablation (RFA) is an effective treatment option for hepatocellular carcinoma (HCC). This study aimed to analyze the prognostic factors of HCC patients treated with RFA and to develop nomograms f...

    Authors: Zhenhua Lu, Zhen Sun, Chengyu Liu, Xiaolei Shi, Rui Li, Weiwei Shao, Yangyang Zheng, Yao Li and Jinghai Song

    Citation: BMC Cancer 2021 21:751

    Content type: Research article

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  25. Surgery is still the mainstay of radical treatment for resectable esophageal cancer (EC). It is apparent that the presence or spread of lymph node metastasis (LNM) is a powerful prognostic factor in patients w...

    Authors: Yutaka Miyawaki, Hiroshi Sato, Shuichiro Oya, Hirofumi Sugita, Yasumitsu Hirano, Shinichi Sakuramoto, Kojun Okamotom, Shigeki Yamaguchim and Isamu Koyama

    Citation: BMC Cancer 2021 21:725

    Content type: Research article

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  26. The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Age would influence...

    Authors: Jing Yu, Caijin Lin, Jiahui Huang, Jin Hong, Weiqi Gao, Siji Zhu, Lin Lin, Xiaosong Chen, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Jiayi Wu and Kunwei Shen

    Citation: BMC Cancer 2021 21:707

    Content type: Research article

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  27. The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older popul...

    Authors: Susanna Niemeläinen, Heini Huhtala, Anu Ehrlich, Jyrki Kössi, Esa Jämsen and Marja Hyöty

    Citation: BMC Cancer 2021 21:698

    Content type: Study protocol

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  28. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study ai...

    Authors: Jiujie Cui, Haiyan Yang, Jue Liu, Donghui Chen, Jiong Hu, Haiyan Zhang, Yu Wang, Ting Han, Tiebo Mao, Feng Jiao, Ewelina Biskup, Yaotian Pan, Min Liu and Liwei Wang

    Citation: BMC Cancer 2021 21:672

    Content type: Research article

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  29. The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).

    Authors: Christer Borgfeldt, Erik Holmberg, Janusz Marcickiewicz, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Angelique Flöter-Rådestad, Maria Bjurberg, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Preben Kjölhede, Per Rosenberg and Thomas Högberg

    Citation: BMC Cancer 2021 21:658

    Content type: Research article

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  30. Clinical practice guidelines recommend active surveillance as the preferred treatment option for low-risk prostate cancer, but only a minority of eligible men receive active surveillance, and practice variatio...

    Authors: Shellie D. Ellis, Soohyun Hwang, Emily Morrow, Kim S. Kimminau, Kelly Goonan, Laurie Petty, Edward Ellerbeck and J. Brantley Thrasher

    Citation: BMC Cancer 2021 21:649

    Content type: Research article

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  31. In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumor...

    Authors: Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park and Woosung Lim

    Citation: BMC Cancer 2021 21:647

    Content type: Research article

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  32. Radical pancreaticoduodenectomy is the most common treatment strategy for patients diagnosed with adenocarcinoma of the pancreatic head. Few studies have reported the clinical characteristics and treatment eff...

    Authors: Chao Wu, Sheng Zhong Hou, Zuowei Wu, Xing Huang, Zihe Wang and Bole Tian

    Citation: BMC Cancer 2021 21:624

    Content type: Research article

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  33. Increasing evidence indicates that site-distant metastases are associated with survival outcomes in patients with epithelial ovarian cancer. This study aimed to investigate the prognostic values of site-distan...

    Authors: Bo Wang, Shixuan Wang and Wu Ren

    Citation: BMC Cancer 2021 21:609

    Content type: Research article

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  34. The influence of lymph node dissection (LND) on survival in patients with head and neck neurogenic tumors remains unclear. We aimed to determine the effect of LND on the outcomes of patients with head and neck...

    Authors: Xiaolian Fang, Shengcai Wang, Junyang Zhao, Yamei Zhang, Jie Zhang, Yanzhen Li, Xiaodan Li, Jun Tai and Xin Ni

    Citation: BMC Cancer 2021 21:598

    Content type: Research article

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  35. The routine clinical use of serum prostatic specific antigen (PSA) testing has allowed earlier detection of low-grade prostate cancer (PCa) with more favourable characteristics, leading to increased acceptance...

    Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla

    Citation: BMC Cancer 2021 21:573

    Content type: Database

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  36. Percutaneous magnetic resonance-guided (MR-guided) MWA procedures have traditionally been performed under local anesthesia (LA) and sedation. However, pain control is often difficult to manage, especially in s...

    Authors: Zhaonan Li, Chaoyan Wang, Jing Li, Zaoqu Liu, Dechao Jiao and Xinwei Han

    Citation: BMC Cancer 2021 21:562

    Content type: Research article

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  37. The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients a...

    Authors: Yihua Wang, Yu Wang, Rui Chen, Zhenrong Tang, Yang Peng, Yudi Jin, Ailin Lan, Nan Ding, Yuran Dai, Linshan Jiang and Shengchun Liu

    Citation: BMC Cancer 2021 21:542

    Content type: Research article

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  38. Neoadjuvant chemotherapy (NACT) was initially applied to locally advanced breast cancer to convert advanced lesions to an operable status. Currently, its application has been expanded to enhance overall oncolo...

    Authors: Jia-Ruei Yang, Wen-Ling Kuo, Chi-Chang Yu, Shin-Cheh Chen and Jung-Ju Huang

    Citation: BMC Cancer 2021 21:522

    Content type: Research article

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  39. Definitive radiation therapy (dRT) is an effective initial treatment of intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). PSMA PET/CT is superior to standard of care imaging (CT, MRI, bone scan)...

    Authors: Jeremie Calais, Shaojun Zhu, Nader Hirmas, Matthias Eiber, Boris Hadaschik, Martin Stuschke, Ken Herrmann, Johannes Czernin, Amar U. Kishan, Nicholas G. Nickols, David Elashoff and Wolfgang P. Fendler

    Citation: BMC Cancer 2021 21:512

    Content type: Study protocol

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  40. To investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificia...

    Authors: Taiyang Zuo, Wenli Lin, Fengyong Liu and Jinshun Xu

    Citation: BMC Cancer 2021 21:505

    Content type: Research article

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  41. Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive treatment which allows delivery of an ablative radiation dose with high accuracy and precision. SABR is an established treatment for both primar...

    Authors: Yoo Young Dominique Lee, Doan Trang Nguyen, Trevor Moodie, Ricky O’Brien, Anne McMaster, Andrew Hickey, Nicole Pritchard, Per Poulsen, Elizaveta Mitkina Tabaksblat, Britta Weber, Esben Worm, David Pryor, Julie Chu, Nicholas Hardcastle, Jeremy Booth, Val Gebski…

    Citation: BMC Cancer 2021 21:494

    Content type: Study protocol

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  42. We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC).

    Authors: Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim and Sang-Soo Seo

    Citation: BMC Cancer 2021 21:489

    Content type: Research article

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  43. Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by bo...

    Authors: Magda Zanelli, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Maria Chiara Bassi, Giacomo Santandrea, Giovanni Martino, Alessandra Soriano, Cecilia Caprera, Matteo Corsi, Stefano Ricci, Linda Ricci and Stefano Ascani

    Citation: BMC Cancer 2021 21:468

    Content type: Research article

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  44. The high incidence and mortality rate of colorectal cancer require new technologies to improve its early diagnosis. This study aims at extracting the medical needs related to the endoscopic technology and the ...

    Authors: Juan Francisco Ortega-Morán, Águeda Azpeitia, Luisa F. Sánchez-Peralta, Luis Bote-Curiel, Blas Pagador, Virginia Cabezón, Cristina L. Saratxaga and Francisco M. Sánchez-Margallo

    Citation: BMC Cancer 2021 21:467

    Content type: Research article

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  45. It is reported that appropriately 50% of early breast cancer patients with 1–2 positive sentinel lymph node (SLN) micro-metastases could not benefit from axillary lymph node dissection (ALND) or breast-conserv...

    Authors: Yang Yu, Zhijun Wang, Zhongyin Wei, Bofan Yu, Peng Shen, Yuan Yan and Wei You

    Citation: BMC Cancer 2021 21:466

    Content type: Research article

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  46. Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Compu...

    Authors: M. P. Engbersen, C. J. V. Rijsemus, J. Nederend, A. G. J. Aalbers, I. H. J. T. de Hingh, V. Retel, D. M. J. Lambregts, E. J. R. J. Van der Hoeven, D. Boerma, M. J. Wiezer, M. De Vries, E. V. E. Madsen, A. R. M. Brandt-Kerkhof, S. Van Koeverden, P. R. De Reuver, R. G. H. Beets-Tan…

    Citation: BMC Cancer 2021 21:464

    Content type: Study protocol

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