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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 13

  1. The prognosis of patients with combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CHC) is usually poor, and effective adjuvant therapy is missing making it important to investigate whether ...

    Authors: Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan and Ying-Hong Shi

    Citation: BMC Cancer 2020 20:642

    Content type: Research article

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  2. To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).

    Authors: Mengmeng Feng, Mengchao Zhang, Yuanqing Liu, Nan Jiang, Qian Meng, Jia Wang, Ziyun Yao, Wenjuan Gan and Hui Dai

    Citation: BMC Cancer 2020 20:611

    Content type: Research article

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  3. Small hepatocellular carcinoma (sHCC) is a special subtype of HCC with the maximum tumor diameter ≤ 3 cm and excellent long-term outcomes. Surgical resection or radiofrequency ablation provides the greatest ch...

    Authors: Yi-hong Ling, Jie-wei Chen, Shi-hong Wen, Chao-yun Huang, Peng Li, Liang-he Lu, Jie Mei, Shao-hua Li, Wei Wei, Mu-yan Cai and Rong-ping Guo

    Citation: BMC Cancer 2020 20:607

    Content type: Research article

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  4. Soft-tissue metastasis (STM) is a relatively rare, but not exceptional, manifestation of lung cancer. The purpose of this study was to evaluate the imaging features of STM from lung cancer using fluorine-18 fl...

    Authors: Tingting Xu, Xinyi Zhang, Shumao Zhang, Chunfeng Liu, Wenhui Fu, Chengrun Zeng and Yue Chen

    Citation: BMC Cancer 2020 20:596

    Content type: Research article

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  5. The prognosis of patients with progressive or recurrent high-grade gliomas (HGGs) after surgery remains poor. Iodine-125 brachytherapy is emerging as a salvage method for the treatment of gliomas. This study a...

    Authors: Congxiao Wang, Shifeng Liu, Lijing Peng, Kaixian Zhang, Wei Li, Hao Zhang, Ying Luan, Peishun Li and Xiaokun Hu

    Citation: BMC Cancer 2020 20:591

    Content type: Research article

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  6. Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets a...

    Authors: Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus and Birgid Schoemig-Markiefka

    Citation: BMC Cancer 2020 20:587

    Content type: Research article

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  7. P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Post-translational protein modification abnormalities have been confirmed to be an important mechanism underlying...

    Authors: Qian Pu, Yan-rong Lv, Ke Dong, Wen-wen Geng and Hai-dong Gao

    Citation: BMC Cancer 2020 20:583

    Content type: Research article

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  8. Non-small cell lung cancer (NSCLC) remains a huge health burden for human health and life worldwide. Our study here was to illuminate the relevance of microRNA-130a-5p (miR-130a-5p) on growth and epithelial me...

    Authors: Fang Ma, Yangchun Xie, Yiyu Lei, Zengshuyu Kuang and Xianling Liu

    Citation: BMC Cancer 2020 20:580

    Content type: Research article

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  9. In patients undergoing major liver resection, portal vein embolization (PVE) has been widely used to induce hypertrophy of the non-embolized liver in order to prevent post-hepatectomy liver failure. PVE is a s...

    Authors: Emmanuel Deshayes, Lauranne Piron, Antoine Bouvier, Bruno Lapuyade, Emilie Lermite, Laurent Vervueren, Christophe Laurent, Jean-Baptiste Pinaquy, Patrick Chevallier, Anthony Dohan, Agnès Rode, Christian Sengel, Chloé Guillot, François Quenet and Boris Guiu

    Citation: BMC Cancer 2020 20:574

    Content type: Study protocol

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  10. This study aims to determine the real incidence of pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor (pPCN) and its prognostic significance in rectal cancer patients.

    Authors: Xuyang Yang, Erliang Zheng, Lina Ye, Chaoyang Gu, Tao Hu, Dan Jiang, Du He, Bing Wu, Qinbing Wu, Tinghan Yang, Mingtian Wei, Wenjian Meng, Xiangbing Deng, Ziqiang Wang and Zongguang Zhou

    Citation: BMC Cancer 2020 20:573

    Content type: Research article

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  11. Prognostic biomarkers provide essential information about a patient’s overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the ...

    Authors: Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara and Masaya Akashi

    Citation: BMC Cancer 2020 20:568

    Content type: Research article

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  12. Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of 13N-ammonia combined with 18F-FDG positron...

    Authors: Lei Ding, Fangling Zhang, Qiao He, Zhoulei Li, Xinchong Shi, Ruocheng Li and Xiangsong Zhang

    Citation: BMC Cancer 2020 20:564

    Content type: Research article

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  13. To explore the correlation of flash dual source computed tomography perfusion imaging (CTPI) and regional lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate the value of CT perfusion ...

    Authors: Tingting Huang, Hui Sun, Xianli Luo, Xuemei Zhang, Kaiyuan Jin, Feng Wang, Lv Sun, Nianlan Cheng, Shuo Wu, Qin Lou and Bangguo Li

    Citation: BMC Cancer 2020 20:547

    Content type: Research article

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  14. Accurate diagnosis of early lung cancer from small pulmonary nodules (SPN) is challenging in clinical setting. We aimed to develop a radiomic nomogram to differentiate lung adenocarcinoma from benign SPN.

    Authors: Qin Liu, Yan Huang, Huai Chen, Yanwen Liu, Ruihong Liang and Qingsi Zeng

    Citation: BMC Cancer 2020 20:533

    Content type: Research article

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  15. According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Du...

    Authors: Yangli Liu, Ying Zhu, Lihong Bai, Fengjia Chen, Jue Wang and Yubiao Guo

    Citation: BMC Cancer 2020 20:520

    Content type: Research article

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  16. Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study...

    Authors: Guorui Zhang, Xin Yu, Lan Zhu, Qingbo Fan, Honghui Shi and Jinghe Lang

    Citation: BMC Cancer 2020 20:514

    Content type: Research article

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  17. The influence of perioperative blood transfusion (PBT) on postsurgical survival of patients with different stage of hepatocellular carcinoma (HCC) is not well clarified. This study aimed to evaluate the impact...

    Authors: Gui-Xing Chen, Chao-Ying Qi, Wen-Jie Hu, Xiao-Hui Wang, Yun-Peng Hua, Ming Kuang, Bao-Gang Peng and Shao-Qiang Li

    Citation: BMC Cancer 2020 20:487

    Content type: Research article

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  18. Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown t...

    Authors: Antoine Brouquet, Jean-Baptiste Bachet, Florence Huguet, Mehdi Karoui, Pascal Artru, Charles Sabbagh, Jérémie H. Lefèvre, Dewi Vernerey, Christophe Mariette, Eric Vicaut and Stephane Benoist

    Citation: BMC Cancer 2020 20:485

    Content type: Study protocol

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  19. Repeat transarterial chemoembolisation (rTACE) is often required for hepatocellular carcinoma (HCC) to achieve disease control, however, current practice guidelines regarding treatment allocation vary signific...

    Authors: Gauri Mishra, Anouk Dev, Eldho Paul, Wa Cheung, Jim Koukounaras, Ashu Jhamb, Ben Marginson, Beng Ghee Lim, Paul Simkin, Adina Borsaru, James Burnes, Mark Goodwin, Vivek Ramachandra, Manfred Spanger, John Lubel, Paul Gow…

    Citation: BMC Cancer 2020 20:483

    Content type: Research article

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  20. High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritone...

    Authors: Agata Mikolajczyk, Tanja Khosrawipour, Joanna Kulas, Pawel Migdal, Mohamed Arafkas, Jakub Nicpon and Veria Khosrawipour

    Citation: BMC Cancer 2020 20:481

    Content type: Research article

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  21. Neoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients’ responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatme...

    Authors: Kai-Yu Sun, Hang-Tong Hu, Shu-Ling Chen, Jin-Ning Ye, Guang-Hua Li, Li-Da Chen, Jian-Jun Peng, Shi-Ting Feng, Yu-Jie Yuan, Xun Hou, Hui Wu, Xin Li, Ting-Fan Wu, Wei Wang and Jian-Bo Xu

    Citation: BMC Cancer 2020 20:468

    Content type: Research article

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  22. Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients’ outcomes inclu...

    Authors: T. M. Ripping, L. A. Kiemeney, L. M. C. van Hoogstraten, J. A. Witjes and K. K. H. Aben

    Citation: BMC Cancer 2020 20:455

    Content type: Study protocol

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  23. The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margi...

    Authors: Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen and Dar-Ren Chen

    Citation: BMC Cancer 2020 20:451

    Content type: Research article

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  24. The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent...

    Authors: Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella M. Björkman-Burtscher, Helena Carén and Asgeir Store Jakola

    Citation: BMC Cancer 2020 20:450

    Content type: Research article

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  25. Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

    Authors: Paula Whitmire, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco Jr, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-de los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej M. Mrugala…

    Citation: BMC Cancer 2020 20:447

    Content type: Research article

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  26. To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as t...

    Authors: Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng and Rongqin Zheng

    Citation: BMC Cancer 2020 20:419

    Content type: Research article

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  27. Neurosurgical resection represents an important treatment option in the modern, multimodal therapy approach of brain metastases (BM). Guidelines for perioperative imaging exist for primary brain tumors to guid...

    Authors: Barbara Kiesel, Carina M. Thomé, Tobias Weiss, Asgeir S. Jakola, Amélie Darlix, Alessia Pellerino, Julia Furtner, Johannes Kerschbaumer, Christian F. Freyschlag, Wolfgang Wick, Matthias Preusser, Georg Widhalm and Anna S. Berghoff

    Citation: BMC Cancer 2020 20:410

    Content type: Research article

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  28. The prognosis of patients with perihilar cholangiocarcinoma have been unsatisfactory. We established new anatomical resectability classification for patients with localized perihilar cholangiocarcinoma and per...

    Authors: Naohisa Kuriyama, Masanobu Usui, Kazuaki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno and Shuji Isaji

    Citation: BMC Cancer 2020 20:405

    Content type: Research article

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  29. Primary debulking surgery (PDS) and adjuvant chemotherapy is the standard treatment for advanced ovarian, fallopian or primary peritoneal cancer. However, neoadjuvant chemotherapy (NAC) followed by interval de...

    Authors: Soo Jin Park, Seung-Hyuk Shim, Yong-Il Ji, Sang-Hoon Kwon, Eun Ji Lee, Maria Lee, Suk Joon Chang, Samina Park, Sang Youn Kim, Sung Jong Lee, Jae-Weon Kim, Ju-Won Roh, San Hui Lee, Taejong Song and Hee Seung Kim

    Citation: BMC Cancer 2020 20:385

    Content type: Study protocol

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  30. In randomized controlled trials (RCTs) of adjuvant treatment for malignant tumors, event-free survival (EFS) is considered the most acceptable surrogate for overall survival (OS). However, even though EFS has ...

    Authors: Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga and Hiroshi Tsumura

    Citation: BMC Cancer 2020 20:379

    Content type: Research article

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  31. While the new Gleason grade grouping (GGG), which started in 2016, has been widely validated in prostate cancer, it does not incorporate the concept of tertiary Gleason pattern 5. Furthermore, no study has “qu...

    Authors: Satoru Taguchi, Yukari Uemura, Tetsuya Fujimura, Teppei Morikawa, Akihiro Naito, Taketo Kawai, Motofumi Suzuki, Haruki Kume and Hiroshi Fukuhara

    Citation: BMC Cancer 2020 20:371

    Content type: Research article

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  32. Conversion surgery (CS) following a response to chemotherapy occasionally leads to prolonged survival in patients with stage IV gastric cancer (GC). This study aimed to evaluate the predictive value of the neu...

    Authors: Naohiko Nakamura, Shinichi Kinami, Yasuto Tomita, Takashi Miyata, Hideto Fujita, Hiroyuki Takamura, Nobuhiko Ueda and Takeo Kosaka

    Citation: BMC Cancer 2020 20:363

    Content type: Research article

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  33. Stereotactic irradiation (STI) is a primary treatment for patients with newly diagnosed brain metastases. Some of these patients experience local progression, which is difficult to differentiate from radiation...

    Authors: Koichi Mitsuya, Yoko Nakasu, Nakamasa Hayashi, Shoichi Deguchi, Takuma Oishi, Takashi Sugino, Kazuaki Yasui, Hirofumi Ogawa, Tsuyoshi Onoe, Hirofumi Asakura and Hideyuki Harada

    Citation: BMC Cancer 2020 20:331

    Content type: Research article

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  34. Pelvic lymph node dissection (PLND) is one of the most important steps in radical prostatectomy (RP). Not only can PLND provide accurate clinical staging to guide treatment after prostatectomy but PLND can als...

    Authors: Jia-Jun Chen, Zai-Sheng Zhu, Yi-Yi Zhu and Hong-Qi Shi

    Citation: BMC Cancer 2020 20:330

    Content type: Research article

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  35. To discuss some inaccurate parts of a published systematic review and meta-analysis which was about comparison of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy for pancreatic ductal ade...

    Authors: Rui Sun, Yifan Zhang and Zhe Su

    Citation: BMC Cancer 2020 20:327

    Content type: Correspondence

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    The original article was published in BMC Cancer 2019 19:781

  36. Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTRs), which is the molecular basis for 68Ga-DOTATOC positron-emission tomography (PET) and radiopeptide therapy (PRRT). However, SSTR ...

    Authors: Manuel Weber, Lukas Kessler, Benedikt Schaarschmidt, Wolfgang Peter Fendler, Harald Lahner, Gerald Antoch, Lale Umutlu, Ken Herrmann and Christoph Rischpler

    Citation: BMC Cancer 2020 20:326

    Content type: Research article

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  37. Response evaluation of neoadjuvant chemotherapy (NACT) in patients with osteosarcoma is significant for the termination of ineffective treatment, the development of postoperative chemotherapy regimens, and the...

    Authors: Bingsheng Huang, Jifei Wang, Meili Sun, Xin Chen, Danyang Xu, Zi-Ping Li, Jinting Ma, Shi-Ting Feng and Zhenhua Gao

    Citation: BMC Cancer 2020 20:322

    Content type: Research article

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  38. The aim of this systematic review and meta-analysis was to compare overall survival and disease-free survival after fertility sparing surgery (FSS) vs radical surgery in stage 1 epithelial ovarian cancer (EOC).

    Authors: Denghua Liu, Jing Cai, Aiwei Gao, Zehua Wang and Liqiong Cai

    Citation: BMC Cancer 2020 20:320

    Content type: Research article

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  39. Isocitrate dehydrogenase 1/2 (IDH1/2), BAP1, ARID1A and PBRM1 have been reported as the most frequent mutant genes in intrahepatic cholangiocarcinoma (ICC), and their relationships with clinicopathological fea...

    Authors: Bingqi Ma, Huijuan Meng, Ye Tian, Yingying Wang, Tianqiang Song, Ti Zhang, Qiang Wu, Yunlong Cui, Huikai Li, Wei Zhang and Qiang Li

    Citation: BMC Cancer 2020 20:318

    Content type: Research article

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  40. Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has...

    Authors: Hai-Bo Sun, Wen-Qun Xing, Xian-Ben Liu, Yan Zheng, Shu-Jun Yang, Zong-Fei Wang, Shi-Lei Liu, Yu-Feng Ba, Rui-Xiang Zhang, Bao-Xing Liu, Cheng-Cheng Fan, Pei-Nan Chen, Guang-Hui Liang, Yong-Kui Yu, Qi Liu, Hao-Ran Wang…

    Citation: BMC Cancer 2020 20:303

    Content type: Study protocol

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  41. The objective of the IMPROVE study was patients’ preference for either endocrine-based therapy or combined chemo- and anti-angiogenic therapy in advanced HR-positive/HER2-negative breast cancer.

    Authors: Thomas Decker, Ulrike Söling, Antje Hahn, Christoph Maintz, Christian Martin Kurbacher, Ursula Vehling-Kaiser, Dagmar Sent, Peter Klare, Volker Hagen, Marco Chiabudini, Julia Falkenstein, Martin Indorf, Eva Runkel and Karin Potthoff

    Citation: BMC Cancer 2020 20:286

    Content type: Research article

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  42. Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.

    Authors: Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi and Wansheng Long

    Citation: BMC Cancer 2020 20:274

    Content type: Research article

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  43. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco

    Citation: BMC Cancer 2020 20:271

    Content type: Case report

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  44. In the past four decades, the incidence of cholangiocarcinoma, especially intrahepatic cholangiocarcinoma (ICC), has raised rapidly worldwide. Completeness of resection, max size of tumor and etc. are widely r...

    Authors: Zeyu Zhang, Yufan Zhou, Kuan Hu, Dong Wang, Zhiming Wang and Yun Huang

    Citation: BMC Cancer 2020 20:270

    Content type: Research article

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  45. Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the fi...

    Authors: John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski and Naris Nilubol

    Citation: BMC Cancer 2020 20:256

    Content type: Case report

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  46. Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...

    Authors: Zerong Cai, Xiaoyu Xie, Yufeng Chen, Zexian Chen, Wuteng Cao, Khamis Salem Saeed Saad, Yifeng Zou, Ping Lan and Xiaojian Wu

    Citation: BMC Cancer 2020 20:253

    Content type: Research article

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