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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 10

  1. Content type: Research article

    To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age.

    Authors: Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Jiejun Xia, Jing Zhang and Shuixing Zhang

    Citation: BMC Cancer 2019 19:693

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  2. Content type: Research article

    Lung cancer is the most important cause of cancer-related deaths worldwide and the overall survival of patients with non-small cell lung cancer has not improved. Transforming growth factor beta or TGF-β is a p...

    Authors: Jue Li, Cheng Shen, Xin Wang, Yutian Lai, Kun Zhou, Pengfei Li, Lunxu Liu and Guowei Che

    Citation: BMC Cancer 2019 19:691

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  3. Content type: Case report

    Chronic lymphocytic leukemia is a malignancy with good prognosis. However, the incidence of secondary tumors increases every year after the diagnosis of chronic lymphotcytic leukemia. One of the induced second...

    Authors: Yinjie Zhu, Yanqing Wang, Zhiyu Qian, Jiahua Pan, Qiang Liu, Baijun Dong and Wei Xue

    Citation: BMC Cancer 2019 19:676

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  4. Content type: Research article

    The neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are representative blood markers of systemic inflammatory responses. However, the clinical significance of the combination of these mar...

    Authors: Tetsushi Hirahara, Takaaki Arigami, Shigehiro Yanagita, Daisuke Matsushita, Yasuto Uchikado, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Itaru Omoto, Hiroshi Kurahara, Kosei Maemura, Keishi Okubo, Yoshikazu Uenosono, Sumiya Ishigami and Shoji Natsugoe

    Citation: BMC Cancer 2019 19:672

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  5. Content type: Case report

    Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radioth...

    Authors: Liam A. Hilleary, Christopher Wratten, Shankar Siva, Jenna Hilleary and Jarad M. Martin

    Citation: BMC Cancer 2019 19:671

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  6. Content type: Research article

    Breast cancer survivors are at risk of developing breast cancer-related lymphedema (BCRL) after surgical treatment, which may have a negative effect on quality of life. The purpose of this study was to investi...

    Authors: Sung Mook Lim, Yujin Han, Seung Il Kim and Hyung Seok Park

    Citation: BMC Cancer 2019 19:669

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  7. Content type: Study protocol

    An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, inv...

    Authors: Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Johanna W. van Sandick, Miguel A. Cuesta, Donald L. van der Peet, Joos Heisterkamp, Grard A. P. Nieuwenhuijzen, Camiel Rosman, Joris J. G. Scheepers, Meindert N. Sosef, Richard van Hillegersberg, Sjoerd M. Lagarde, Magnus Nilsson, Jari Räsänen, Philippe Nafteux, Piet Pattyn…

    Citation: BMC Cancer 2019 19:662

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  8. Content type: Research article

    Yes-associated protein (YAP) plays a crucial role in tumour development and it is the main effector of the Hippo signalling pathway. However, the mechanism underlying YAP downregulation in laryngeal cancer is ...

    Authors: Xiaomin Tang, Yuxuan Sun, Ganglun Wan, Jiaqiang Sun, Jingwu Sun and Chunchen Pan

    Citation: BMC Cancer 2019 19:654

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  9. Content type: Research article

    The optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the clinical value and complications of segm...

    Authors: Kai Zheng, Xiu-chun Yu, Yong-cheng Hu, Zeng-wu Shao, Ming Xu, Bai-chuan Wang and Feng Wang

    Citation: BMC Cancer 2019 19:638

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  10. Content type: Research article

    The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of pros...

    Authors: Heike Endepols, Agnieszka Morgenroth, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Raphael Richarz, Sergio Muñoz Vásquez, Bernd Neumaier and Felix M. Mottaghy

    Citation: BMC Cancer 2019 19:633

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  11. Content type: Research article

    A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to ther...

    Authors: Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie J. Sandberg, Swapnil Potdar, Aija Kyttälä, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo

    Citation: BMC Cancer 2019 19:628

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  12. Content type: Research article

    Sentinel node biopsy (SNB) is the standard procedure for axillary staging in patients with clinically lymph node negative invasive breast cancer. Completion axillary lymph node dissection (c-ALND) may not be n...

    Authors: Shabaz Majid, Lisa Rydén and Jonas Manjer

    Citation: BMC Cancer 2019 19:626

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  13. Content type: Research article

    Sentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for patients with benign sentinel nodes. For patients with positive sentinel nod...

    Authors: Looket Dihge, Mattias Ohlsson, Patrik Edén, Pär-Ola Bendahl and Lisa Rydén

    Citation: BMC Cancer 2019 19:610

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  14. Content type: Study protocol

    Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectom...

    Authors: Yang Yang, Xiaobin Zhang, Bin Li, Zhigang Li, Yifeng Sun, Teng Mao, Rong Hua, Yu Yang, Xufeng Guo, Yi He, Hecheng Li, Hezhong Chen and Lijie Tan

    Citation: BMC Cancer 2019 19:608

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  15. Content type: Research article

    Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve lo...

    Authors: Malin Sternby Eilard, Mats Andersson, Peter Naredi, Charalampos Geronymakis, Per Lindnér, Christian Cahlin, William Bennet and Magnus Rizell

    Citation: BMC Cancer 2019 19:568

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  16. Content type: Research article

    Pre-operative discrimination of malignant from benign adnexal masses is crucial for planning additional imaging, preparation, surgery and postoperative care. This study aimed to define key ultrasound and clini...

    Authors: Maciej Stukan, Michał Badocha and Karol Ratajczak

    Citation: BMC Cancer 2019 19:564

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  17. Content type: Case report

    Cabazitaxel (CBZ) chemotherapy for metastatic castration-resistant prostate cancer (mCRPC) is believed to be palliative because the radiological response rate is low and a durable response is rare. Here, we de...

    Authors: Takeo Kosaka, Hiroshi Hongo and Mototsugu Oya

    Citation: BMC Cancer 2019 19:562

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  18. Content type: Research article

    Despite recent advances in the treatments of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains controversial. The purpose of this study was to investigate the prognostic performance of pret...

    Authors: Mian-Tao Wu, Su-Yin He, Shu-Lin Chen, Lin-Fang Li, Zheng-Qiang He, Yuan-Ying Zhu, Xia He and Hao Chen

    Citation: BMC Cancer 2019 19:538

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  19. Content type: Case report

    Basaloid squamous cell carcinoma of the esophagus (BSCCE) is generally detected at advanced stage and the prognosis is poorer than advanced conventional esophageal squamous cell carcinoma. Therefore, early det...

    Authors: Lianjun Di, Kuang-I Fu, Xinglong Wu, Xuemei Liu, Rui Xie, Rong Zhu and Biguang Tuo

    Citation: BMC Cancer 2019 19:513

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  20. Content type: Research article

    To investigate the long-term efficacy of the minimally invasive Ivor Lewis esophagectomy (MIILE) in esophageal squamous cell carcinoma (ESCC) patients, a retrospective comparison of the quality of life (QOL) a...

    Authors: Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen and Ming Wu

    Citation: BMC Cancer 2019 19:500

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  21. Content type: Research article

    To determine whether magnetic resonance imaging (MRI)-detected extramural vascular invasion (mrEMVI) status is associated with quantitative perfusion parameters derived from dynamic contrast-enhanced MRI (DCE-...

    Authors: Yan Chen, Xinyue Yang, Ziqiang Wen, Yiyan Liu, Baolan Lu, Shenping Yu and Xiaojuan Xiao

    Citation: BMC Cancer 2019 19:498

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  22. Content type: Research article

    The traditional pathologic grading for human renal cell carcinoma (RCC) has low concordance between biopsy and surgical specimen. There is a need to investigate adjunctive pathology technique that does not rel...

    Authors: Sara L. Best, Yuming Liu, Adib Keikhosravi, Cole R. Drifka, Kaitlin M. Woo, Guneet S. Mehta, Marie Altwegg, Terra N. Thimm, Matthew Houlihan, Jeremy S. Bredfeldt, E. Jason Abel, Wei Huang and Kevin W. Eliceiri

    Citation: BMC Cancer 2019 19:490

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  23. Content type: Research article

    Laparoscopic-assisted pylorus-preserving gastrectomy (LAPPG) is a minimally invasive function-preserving surgery for early gastric cancer. This study was designed to investigate the clinical outcomes between L...

    Authors: Xiang Xia, Jia Xu, Chunchao Zhu, Hui Cao, Fengrong Yu and Gang Zhao

    Citation: BMC Cancer 2019 19:481

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  24. Content type: Research article

    To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

    Authors: Tao-xiang Huang, Nian Lu, Shan-shan Lian, Hui Li, Shao-han Yin, Zhi-jun Geng and Chuan-miao Xie

    Citation: BMC Cancer 2019 19:470

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  25. Content type: Research article

    The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and nar...

    Authors: Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni and Pasquale Capaccio

    Citation: BMC Cancer 2019 19:467

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  26. Content type: Research article

    The prevalence and factors associated with major depressive disorder (MDD) among adults with cancer have been documented in the scientific literature. However, this data is limited among children and adolescen...

    Authors: Benedict Akimana, Catherine Abbo, Joyce Balagadde-Kambugu and Etheldreda Nakimuli-Mpungu

    Citation: BMC Cancer 2019 19:466

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  27. Content type: Research article

    To explore imaging biomarkers that can be used for diagnosis and prediction of pathologic stage in non-small cell lung cancer (NSCLC) using multiple machine learning algorithms based on CT image feature analysis.

    Authors: Lingming Yu, Guangyu Tao, Lei Zhu, Gang Wang, Ziming Li, Jianding Ye and Qunhui Chen

    Citation: BMC Cancer 2019 19:464

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  28. Content type: Research article

    Patients undergoing major cancer surgery frequently require post-acute care for complications and adverse effects. Enhanced recovery after surgery programmes mean that patients are increasingly discharged home...

    Authors: Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova and Jane M. Blazeby

    Citation: BMC Cancer 2019 19:463

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  29. Content type: Research article

    Purpose of this study was to analyze whether preoperative maximum standardized uptake value (SUVmax) and carbohydrate antigen 19–9 (CA19–9) levels might provide prognostic information in Chinese patients with ...

    Authors: Xinjin Gu, Ruiquan Zhou, Chenggang Li, Rong Liu, Zhiming Zhao, Yuanxing Gao and Yong Xu

    Citation: BMC Cancer 2019 19:456

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  30. Content type: Research article

    Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph n...

    Authors: Fei Zhao, Fu-Xi Zhen, Yue Zhou, Chen-Jun Huang, Yue Yu, Jun Li, Qi-Fan Li, Cheng-Xiang Zhu, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Liang Chen and Wei Wang

    Citation: BMC Cancer 2019 19:444

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  31. Content type: Research article

    Colorectal cancer remains the second leading cause of cancer death in the United States, and increased risk in patients with ulcerative colitis (a subset of inflammatory bowel disease) has motivated studies in...

    Authors: Sandra P. Prieto, Cassandra L. Reed, Haley M. James, Kyle P. Quinn and Timothy J. Muldoon

    Citation: BMC Cancer 2019 19:428

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  32. Content type: Technical advance

    pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). ...

    Authors: Leen Van de Sande, Wouter Willaert, Sarah Cosyns, Kaat De Clercq, Molood Shariati, Katrien Remaut and Wim Ceelen

    Citation: BMC Cancer 2019 19:424

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  33. Content type: Study protocol

    At present, palliative systemic chemotherapy is the standard treatment in the Netherlands for gastric cancer patients with peritoneal dissemination. In contrast to lymphatic and haematogenous dissemination, pe...

    Authors: W. J. Koemans, R. T. van der Kaaij, H. Boot, T. Buffart, A. A. F. A. Veenhof, K. J. Hartemink, C. Grootscholten, P. Snaebjornsson, V. P. Retel, H. van Tinteren, S. Vanhoutvin, V. van der Noort, A. Houwink, C. Hahn, A. D. R. Huitema, M. Lahaye…

    Citation: BMC Cancer 2019 19:420

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  34. Content type: Research article

    Postoperative chemotherapy is beneficial for many pancreatic cancer patients. However, some patients require dose reduction or the discontinuation of adjuvant chemotherapy because of adverse treatment-related ...

    Authors: Yoshifumi Morita, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yasushi Shibasaki, Hirotoshi Kikuchi, Hiroyuki Konno and Hiroya Takeuchi

    Citation: BMC Cancer 2019 19:416

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  35. Content type: Study protocol

    Immunotherapies targeting the PD1/PD-L1 pathway have had a large impact on the treatment of advanced NSCLC. Concerning multimodality tumor therapy, only few trials until today have been performed investigating...

    Authors: Florian Eichhorn, Laura V. Klotz, Helge Bischoff, Michael Thomas, Felix Lasitschka, Hauke Winter, Hans Hoffmann and Martin E. Eichhorn

    Citation: BMC Cancer 2019 19:413

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  36. Content type: Research article

    To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate ...

    Authors: Enxin Wang, Dongdong Xia, Wei Bai, Jie Yuan, Xiaomei Li, Jing Niu, Zhanxin Yin, Jielai Xia, Hongwei Cai, Daiming Fan, Guohong Han and Lei Liu

    Citation: BMC Cancer 2019 19:409

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  37. Content type: Study protocol

    Preoperative chemoradiotherapy (pre-CRT) followed by total mesorectal excision (TME) is currently a standard therapy for locally advanced mid-to-low rectal cancer. Less aggressive, organ-preserving option such...

    Authors: Jong Lyul Lee, Seok-Byung Lim, Chang Sik Yu, In Ja Park, Yong Sik Yoon, Chan Wook Kim, Seong Ho Park, Jong Seok Lee, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jong Hoon Kim, Jin-hong Park, Jihun Kim and Minkyu Han

    Citation: BMC Cancer 2019 19:404

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  38. Content type: Research article

    Locally advanced pancreatic cancer (LAPC) represents more than one third of pancreatic cancers and owns poor survival after the standard chemotherapy. Irreversible electroporation (IRE) is a novel method and h...

    Authors: Chaobin He, Jun Wang, Shuxin Sun, Yu Zhang, Xiaojun Lin, Xiangming Lao, Bokang Cui and Shengping Li

    Citation: BMC Cancer 2019 19:394

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  39. Content type: Study protocol

    Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of peri...

    Authors: Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul…

    Citation: BMC Cancer 2019 19:390

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  40. Content type: Case report

    Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining. Ovarian metastasis from cervical cancer is a rare phenomenon, the mechanism of dissemination...

    Authors: Alexandra Arfi, Delphine Hequet, Guillaume Bataillon, Carine Tran-Perennou, Fereshteh Farkhondeh, Xavier Sastre-Garau, Virginie Fourchotte, Roman Rouzier, Enora Laas, Nicolas Pouget, Anne Vincent-Salomon and Emmanuelle Jeannot

    Citation: BMC Cancer 2019 19:375

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  41. Content type: Research article

    As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy i...

    Authors: Xue Chao, Kai Chen, Jiayi Zeng, Zhuofei Bi, Mingyan Guo, Yi Chen, Yandan Yao, Wei Wu, Shi Liang and Yan Nie

    Citation: BMC Cancer 2019 19:372

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  42. Content type: Research article

    Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

    Authors: Kun Huang, Zhi Dong, Huasong Cai, Mengqi Huang, Zhenpeng Peng, Ling Xu, Yingmei Jia, Chenyu Song, Zi-Ping Li and Shi-Ting Feng

    Citation: BMC Cancer 2019 19:364

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  43. Content type: Case report

    Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st...

    Authors: Tae-Woo Nam, Hyun-Min Oh, Jae-Eun Lee, Ju-Hyun Kim, Jong-moon Hwang, Eunhee Park and Tae-Du Jung

    Citation: BMC Cancer 2019 19:347

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