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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 14

  1. Despite obvious advances over the last decades, locally advanced adenocarcinomas of the gastroesophageal junction (GEJ) still carry a dismal prognosis with overall 5-year survival rates of less than 50% even w...

    Authors: Sylvie Lorenzen, Alexander Biederstädt, Ulrich Ronellenfitsch, Christoph Reißfelder, Stefan Mönig, Frederik Wenz, Claudia Pauligk, Martin Walker, Salah-Eddin Al-Batran, Bernhard Haller and Ralf-Dieter Hofheinz

    Citation: BMC Cancer 2020 20:886

    Content type: Study protocol

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  2. Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The pur...

    Authors: Yusuke Shinoda, Eisuke Kobayashi, Hiroshi Kobayashi, Tomoaki Mori, Naofumi Asano, Robert Nakayama, Hideo Morioka, Shintaro Iwata, Tsukasa Yonemoto, Takeshi Ishii, Tohru Hiruma, Akira Kawai and Hirotaka Kawano

    Citation: BMC Cancer 2020 20:883

    Content type: Research article

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  3. Recent studies have shown that chemotherapy destabilizes the blood vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic cancer patients (Met-pa). CTCs are a precurso...

    Authors: Nerymar Ortiz-Otero, Jocelyn R. Marshall, Bradley Lash and Michael R. King

    Citation: BMC Cancer 2020 20:873

    Content type: Research article

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  4. The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy ...

    Authors: Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka and Hideki Murakami

    Citation: BMC Cancer 2020 20:868

    Content type: Research article

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  5. The aim of this study is to assess biplane transrectal ultrasonography (TRUS) plus ultrasonic elastosonography (UE) and contrast-enhanced ultrasonography (CEUS) in T staging of rectal cancer.

    Authors: Yanru Feng, Chanjuan Peng, Yuan Zhu and Luying Liu

    Citation: BMC Cancer 2020 20:862

    Content type: Research article

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  6. The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph n...

    Authors: Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu and Jianye Wang

    Citation: BMC Cancer 2020 20:851

    Content type: Research article

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  7. We aimed to identify which part of the patients with metastatic renal cell carcinoma (mRCC) is not suitable for cytoreductive nephrectomy (CN).

    Authors: Zhao Zhang, Hongliang Wu, Tong Yang, Yaohai Wu, Nengwang Yu and Zhonghua Xu

    Citation: BMC Cancer 2020 20:844

    Content type: Research article

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  8. Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in p...

    Authors: Takashi Okuyama, Shinichi Sameshima, Emiko Takeshita, Takashi Mitsui, Takuji Noro, Yuko Ono, Tamaki Noie, Shinichi Ban and Masatoshi Oya

    Citation: BMC Cancer 2020 20:842

    Content type: Research article

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  9. Existing imaging techniques have a low ability to detect lymph node metastasis (LNM) of gallbladder cancer (GBC). Gallbladder removal by laparoscopic cholecystectomy can provide pathological information regard...

    Authors: Yingnan Yang, Zhuolong Tu, Huajie Cai, Bingren Hu, Chentao Ye and Jinfu Tu

    Citation: BMC Cancer 2020 20:828

    Content type: Research article

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  10. Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favor...

    Authors: Dieter H. Heiland, Robin Ohle, Debora Cipriani, Pamela Franco, Daniel Delev, Simon P. Behriger, Elias Kellner, Gergana Petrova, Nicolas Neidert, Irina Mader, Mateo Fariña Nuñez, Horst Urbach, Roman Sankowski, Jürgen Beck and Oliver Schnell

    Citation: BMC Cancer 2020 20:818

    Content type: Research article

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  11. Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ ...

    Authors: Jing Zhao, Qiang Li, Merlin Muktiali, Bingjie Ren, Yingxi Hu, Dapeng Li, Zhi Li, Daoming Li, Yufeng Xie, Min Tao and Rongrui Liang

    Citation: BMC Cancer 2020 20:812

    Content type: Research article

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  12. This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in m...

    Authors: Xiling Yu, Xueke Li, Yue Xing, Siduo Lu, Silvia Tanumiharjo and Jin Ma

    Citation: BMC Cancer 2020 20:808

    Content type: Research article

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  13. The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications...

    Authors: Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao…

    Citation: BMC Cancer 2020 20:801

    Content type: Study protocol

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  14. The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of pulmonary tumors remained debatable among published studies. This study aimed t...

    Authors: Jianye Liang, Jing Li, Zhipeng Li, Tiebao Meng, Jieting Chen, Weimei Ma, Shen Chen, Xie Li, Yaopan Wu and Ni He

    Citation: BMC Cancer 2020 20:799

    Content type: Research article

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  15. Adenocarcinoma of the gastroesophageal junction (GEJ) Siewert type II can be resected by transthoracic esophagectomy or transhiatal extended gastrectomy. Both allow for a complete tumor resection, yet there is...

    Authors: Jessica M. Leers, Laura Knepper, Arjen van der Veen, Wolfgang Schröder, Hans Fuchs, Petra Schiller, Martin Hellmich, Ulrike Zettelmeyer, Lodewijk A. A. Brosens, Alexander Quaas, Jelle P. Ruurda, Richard van Hillegersberg and Christiane J. Bruns

    Citation: BMC Cancer 2020 20:781

    Content type: Study protocol

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  16. The influence of anastomotic leakage (AL) on local recurrence rates and survival in rectal cancer remains controversial. The aim of this study was to analyze the effect of asymptomatic anastomotic leakage (AAL...

    Authors: Alice Artus, Nicolas Tabchouri, Othman Iskander, Nicolas Michot, Olivier Muller, Urs Giger-Pabst, Pascal Bourlier, Céline Bourbao-Tournois, Aurore Kraemer-Bucur, Thierry Lecomte, Ephrem Salamé and Mehdi Ouaissi

    Citation: BMC Cancer 2020 20:780

    Content type: Research article

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  17. Gastric neoplasms containing neuroendocrine carcinoma (NEC) components are rare malignancies with highly aggressive behavior and a poor prognosis and include pure NEC and mixed tumors containing NEC components...

    Authors: Jiahui Chen, Anqiang Wang, Ke Ji, Zhaode Bu and Jiafu Ji

    Citation: BMC Cancer 2020 20:777

    Content type: Research article

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  18. To evaluate proton-density fat-fraction (PDFF) and intravoxel incoherent motion (IVIM) techniques, and human 25-hydroxyvitamin D3 (25OH-VitD3) levels, as potential biomarkers in patients with colorectal cancer...

    Authors: Qian Wang, Feng Ye, Peiqing Ma, Yiqun Che, Weilan Guo, Dong Yan and Xinming Zhao

    Citation: BMC Cancer 2020 20:767

    Content type: Research article

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  19. In patients with differentiated thyroid cancer (DTC), tumor burden of persistent disease (PD) is a variable that could affect therapy efficiency. Our aim was to assess its correlation with the 2015 American Th...

    Authors: Renaud Ciappuccini, Natacha Heutte, Audrey Lasne-Cardon, Virginie Saguet-Rysanek, Camille Leroy, Véronique Le Hénaff, Dominique Vaur, Emmanuel Babin and Stéphane Bardet

    Citation: BMC Cancer 2020 20:765

    Content type: Research article

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  20. The likelihood of a tumor recurrence in patients with T3-4N0–1 non-small cell lung cancer following multimodality treatment remains substantial, mainly due distant metastases. As pathological complete response...

    Authors: Chris Dickhoff, Suresh Senan, Famke L. Schneiders, Joris Veltman, Sayed Hashemi, Johannes M. A. Daniels, Marieke Fransen, David J. Heineman, Teodora Radonic, Peter M. van de Ven, Imke H. Bartelink, Lilian J. Meijboom, Juan J. Garcia-Vallejo, Daniela E. Oprea-Lager, Tanja D. de Gruijl and Idris Bahce

    Citation: BMC Cancer 2020 20:764

    Content type: Study protocol

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  21. To evaluate the feasibility and effectiveness of artificial ascites to assist thermal ablation of liver cancer adjacent to the gastrointestinal tract in patients with previous abdominal surgery.

    Authors: Qiannan Huang, Jianguo Li, Qingjing Zeng, Lei Tan, Rongqin Zheng, Xuqi He and Kai Li

    Citation: BMC Cancer 2020 20:763

    Content type: Research article

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  22. Globally, colorectal cancer (CRC) is the third and second leading cancer in men and women respectively with 600,000 deaths per year. Traditionally, clinicians have relied solely on nodal disease involvement, a...

    Authors: Ali Riaz Baqar, Simon Wilkins, Wei Wang, Karen Oliva and Paul McMurrick

    Citation: BMC Cancer 2020 20:762

    Content type: Research article

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  23. This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC).

    Authors: Hong Yang, Zhendan Yao, Ming Cui, Jiadi Xing, Chenghai Zhang, Nan Zhang, Maoxing Liu, Kai Xu, Fei Tan and Xiangqian Su

    Citation: BMC Cancer 2020 20:761

    Content type: Research article

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  24. Living donor liver transplantation (LDLT) is an acceptable treatment option for hepatocellular carcinoma (HCC). Traditional transplant criteria aim at best utilization of donor organs with low risk of post tra...

    Authors: Abu Bakar Hafeez Bhatti, Ammal Imran Qureshi, Rizmi Tahir, Faisal Saud Dar, Nusrat Yar Khan, Haseeb Haider Zia, Shahzad Riyaz and Atif Rana

    Citation: BMC Cancer 2020 20:754

    Content type: Research article

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  25. NLR, PLR, and LMR have been associated with pancreatic ductal adenocarcinoma (PDAC) survival. Prognostic value and optimal cutpoints were evaluated to identify underlying significance in surgical PDAC patients.

    Authors: David T. Pointer Jr., David Roife, Benjamin D. Powers, Gilbert Murimwa, Sameh Elessawy, Zachary J. Thompson, Michael J. Schell, Pamela J. Hodul, Jose M. Pimiento, Jason B. Fleming and Mokenge P. Malafa

    Citation: BMC Cancer 2020 20:750

    Content type: Research article

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  26. At the time of surgery, approximately 10–20% of the patients with pancreatic cancer are considered unresectable because of unexpected liver metastasis, peritoneal carcinomatosis or locally advanced disease. Th...

    Authors: G. Litjens, D. M. Rivière, E. J. M. van Geenen, S. A. Radema, L. A. A. Brosens, M. Prokop, C. J. H. M. van Laarhoven and J. J. Hermans

    Citation: BMC Cancer 2020 20:744

    Content type: Study protocol

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  27. Seroma formation is a common complication after breast cancer surgery and can lead to delayed wound healing, infection, patient discomfort and repeated visits to the outpatient clinic. Mastectomy combined with...

    Authors: Lisa de Rooij, Sander M. J. van Kuijk, Els R. M. van Haaren, Alfred Janssen, Yvonne L. J. Vissers, Geerard L. Beets and James van Bastelaar

    Citation: BMC Cancer 2020 20:735

    Content type: Study protocol

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  28. Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 (UGT1A1) is a predictive biomarker for the side-effects of irinotecan chemotherapy, which reduces the volume of tumors harboring UGT1A1 polymorp...

    Authors: Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba and Masaki Mandai

    Citation: BMC Cancer 2020 20:729

    Content type: Research article

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  29. To evaluate the impact of Gallium-68 [68Ga] labeled prostate specific membrane antigen (PSMA) positron emission tomography (PET)/X-ray computed tomography (CT) compared with conventional imaging on staging and cl...

    Authors: Maarten L. Donswijk, Pim J. van Leeuwen, Erik Vegt, Zing Cheung, Stijn W. T. P. J. Heijmink, Henk G. van der Poel and Marcel P. M. Stokkel

    Citation: BMC Cancer 2020 20:723

    Content type: Research article

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  30. To observe the medium- and long-term clinical efficacy and safety of radioactive 125I seed implantation for refractory malignant tumours based on CT-guided 3D template-assisted technique.

    Authors: Guang Sheng Zhao, Song Liu, Liang Yang, Chuang Li, Ruo Yu Wang, Jun Zhou and Yue Wei Zhang

    Citation: BMC Cancer 2020 20:718

    Content type: Research article

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  31. Studying entire dietary patterns is a promising alternative approach to overcome limitations of the single food or nutrient approach. We evaluated the relationship between the scores of 4 established Dietary A...

    Authors: Zeinab Heidari, Elahe Mohammadi, Vahideh Aghamohammadi, Saba Jalali, Arezoo Rezazadeh, Fatemeh Sedaghat, Mojan Assadi and Bahram Rashidkhani

    Citation: BMC Cancer 2020 20:708

    Content type: Research article

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  32. This study aimed to comprehensively investigate the effect of spread through air spaces (STAS) on clinicopathologic features, molecular characteristics, immunohistochemical expression, and prognosis in lung ad...

    Authors: Meng Jia, Shili Yu, Jiaqi Yu, Yuemin Li, Hongwen Gao and Ping-Li Sun

    Citation: BMC Cancer 2020 20:705

    Content type: Research article

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  33. Advanced stage operable cancers of larynx are treated with total laryngectomy including thyroid resection in most of the cases, which may expose patient to hypothyroidism and hypoparathyroidism. The requiremen...

    Authors: Surendra Singh Baghel, Pawan Singhal, Namita Verma, Ritu Sehra, Rajeev Yadav, Sunita Agarwal, Man Prakash Sharma and D. P. Gupta

    Citation: BMC Cancer 2020 20:700

    Content type: Research article

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  34. Although surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been satisfactory. Adjuvant therapy with S-1 may improve survival in patients with BT...

    Authors: Osamu Itano, Yusuke Takemura, Norihiro Kishida, Eiji Tamagawa, Hiroharu Shinozaki, Ken Ikeda, Hidejiro Urakami, Shigenori Ei, Shigeo Hayatsu, Keiichi Suzuki, Tadayuki Sakuragawa, Masatsugu Ishii, Masaya Shito, Koichi Aiura, Hiroto Fujisaki, Kiminori Takano…

    Citation: BMC Cancer 2020 20:688

    Content type: Research article

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  35. Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have ...

    Authors: Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida

    Citation: BMC Cancer 2020 20:681

    Content type: Research article

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  36. For patients with mid and distal rectal cancer, robust evidence on long-term outcome and causal treatment effects of transanal total mesorectal excision (TaTME) is lacking. This multicentre retrospective cohor...

    Authors: F. B. de Lacy, S. X. Roodbeen, J. Ríos, J. van Laarhoven, A. Otero-Piñeiro, R. Bravo, T. Visser, R. van Poppel, S. Valverde, R. Hompes, C. Sietses, A. Castells, W. A. Bemelman, P. J. Tanis and A. M. Lacy

    Citation: BMC Cancer 2020 20:677

    Content type: Research article

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  37. To investigate whether there is a distinct difference in prognosis between hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) and whether HAS can benefit from...

    Authors: Kai Zhou, Anqiang Wang, Sheng Ao, Jiahui Chen, Ke Ji, Qifei He, Xin Ji, Xiaojiang Wu, Ji Zhang, Zhongwu Li, Zhaode Bu and Jiafu Ji

    Citation: BMC Cancer 2020 20:671

    Content type: Research article

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  38. Few studies have been designed to evaluate the short-term outcomes between robotic-assisted total gastrectomy (RATG) and laparoscopy-assisted total gastrectomy (LATG) for advanced gastric cancer (AGC). The pur...

    Authors: Changdong Yang, Yan Shi, Shaohui Xie, Jun Chen, Yongliang Zhao, Feng Qian, Yingxue Hao, Bo Tang and Peiwu Yu

    Citation: BMC Cancer 2020 20:669

    Content type: Research article

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  39. This study aimed to establish a novel nomogram prognostic model to predict death probability for non-small cell lung cancer (NSCLC) patients who received surgery..

    Authors: Bo Jia, Qiwen Zheng, Jingjing Wang, Hongyan Sun, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Xue Yang, Jia Zhong, Hanxiao Chen, Yujia Chi, Xiaoyu Zhai and Ziping Wang

    Citation: BMC Cancer 2020 20:666

    Content type: Research article

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  40. To compare adenocarcinoma (AC) and adenosquamous carcinoma (ASC) prognoses in patients with FIGO stage IB–IIA cervical cancer who underwent radical hysterectomy.

    Authors: Xiaojing Zhang, Zunfu Lv, Xiaoxian Xu, Zhuomin Yin and Hanmei Lou

    Citation: BMC Cancer 2020 20:664

    Content type: Research article

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  41. Toremifene (TOR) is a selective oestrogen receptor modulator (SERM) and has comparable efficacy to that of tamoxifen (TAM) in breast cancer patients. Herein, we compared the safety of TOR to that of TAM in the...

    Authors: Jin Hong, Jiahui Huang, Lili Shen, Siji Zhu, Weiqi Gao, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen

    Citation: BMC Cancer 2020 20:663

    Content type: Research article

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  42. The introduction of complete mesocolic excision (CME) with central vascular ligation (CVL) for right-sided colon cancer has improved the oncologic outcomes. Recently, we have introduced a modified CME (mCME) p...

    Authors: Seung Yoon Yang, Min Jung Kim, Bong-Hyeon Kye, Yoon Dae Han, Min Soo Cho, Seung-Yong Jeong, Hyeon-Min Cho, Hyunki Kim, Gyeong Hoon Kang, Seung Ho Song, Jun Seok Park, Ji-Seon Kim, Soo Yeun Park, Jin Kim and Byung Soh Min

    Citation: BMC Cancer 2020 20:657

    Content type: Study protocol

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  43. Systematic retroperitoneal lymphadenectomy has been widely used in the surgical treatment of advanced ovarian cancer patients. Nevertheless, the corresponding therapeutic may not provide a survival benefit. Th...

    Authors: Chenyan Fang, Yingli Zhang, Lingqin Zhao, Xi Chen, Liang Xia and Ping Zhang

    Citation: BMC Cancer 2020 20:654

    Content type: Research article

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  44. Fibroepithelial lesions of the breast include fibroadenoma (FA) and phyllodes tumor (PT). Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of dis...

    Authors: Santosh Tummidi, Kanchan Kothari, Mona Agnihotri, Leena Naik and Prashant Sood

    Citation: BMC Cancer 2020 20:648

    Content type: Research article

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  45. The prognosis of patients with combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CHC) is usually poor, and effective adjuvant therapy is missing making it important to investigate whether ...

    Authors: Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan and Ying-Hong Shi

    Citation: BMC Cancer 2020 20:642

    Content type: Research article

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  46. To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).

    Authors: Mengmeng Feng, Mengchao Zhang, Yuanqing Liu, Nan Jiang, Qian Meng, Jia Wang, Ziyun Yao, Wenjuan Gan and Hui Dai

    Citation: BMC Cancer 2020 20:611

    Content type: Research article

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  47. Small hepatocellular carcinoma (sHCC) is a special subtype of HCC with the maximum tumor diameter ≤ 3 cm and excellent long-term outcomes. Surgical resection or radiofrequency ablation provides the greatest ch...

    Authors: Yi-hong Ling, Jie-wei Chen, Shi-hong Wen, Chao-yun Huang, Peng Li, Liang-he Lu, Jie Mei, Shao-hua Li, Wei Wei, Mu-yan Cai and Rong-ping Guo

    Citation: BMC Cancer 2020 20:607

    Content type: Research article

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