Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

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  1. Study protocol

    Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter study

    In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh

    BMC Cancer 2017 17:649

    Published on: 15 September 2017

  2. Research article

    The safety and efficacy of transarterial chemoembolization combined with sorafenib and sorafenib mono-therapy in patients with BCLC stage B/C hepatocellular carcinoma

    Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear.

    Fei-Xiang Wu, Jie Chen, Tao Bai, Shao-Liang Zhu, Tian-Bo Yang, Lu-Nan Qi, Ling Zou, Zi-Hui Li, Jia-Zhou Ye and Le-Qun Li

    BMC Cancer 2017 17:645

    Published on: 12 September 2017

  3. Case report

    Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours

    A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We ...

    Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely and Hajnalka Vago

    BMC Cancer 2017 17:612

    Published on: 2 September 2017

  4. Case report

    Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient

    The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response ra...

    Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens and Philippe G. Jorens

    BMC Cancer 2017 17:586

    Published on: 29 August 2017

  5. Research article

    Prognostic significance of E-cadherin and N-cadherin expression in Gliomas

    Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked to tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of r...

    Myung-Giun Noh, Se-Jeong Oh, Eun-Jung Ahn, Yeong-Jin Kim, Tae-Young Jung, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Kyung-Hwa Lee and Kyung-Sub Moon

    BMC Cancer 2017 17:583

    Published on: 29 August 2017

  6. Research article

    Distinct preoperative clinical features predict four histopathological subtypes of high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum

    The Cancer Genome Atlas Research Network reported that high-grade serous carcinoma (HGSC) can be classified based on gene expression profiles into four subtypes, termed “immunoreactive,” “differentiated,” “pro...

    Takuma Ohsuga, Ken Yamaguchi, Aki Kido, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondoh, Tsukasa Baba, Ikuo Konishi and Noriomi Matsumura

    BMC Cancer 2017 17:580

    Published on: 29 August 2017

  7. Case report

    Rare triad of periampullary carcinoid, duodenal gastrointestinal stromal tumor and plexiform neurofibroma at hepatic hilum in neurofibromatosis type 1: a case report

    Neurofibromatosis type 1 is a relatively common inherited disorder. Patients with neurofibromatosis type 1 are at high risk of developing neurogenic, neuroendocrine and mesenchymal intra-abdominal tumors. Alth...

    Nihed Abdessayed, Rahul Gupta, Sarra Mestiri, Ahlem Bdioui, Mounir Trimech and Moncef Mokni

    BMC Cancer 2017 17:579

    Published on: 29 August 2017

  8. Research article

    Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer

    Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF)...

    Anders Christensen, Katalin Kiss, Giedrius Lelkaitis, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Julie Lyng Forman, Anne Lyngholm Sørensen, David Hebbelstrup Jensen, Andreas Kjaer and Christian von Buchwald

    BMC Cancer 2017 17:572

    Published on: 25 August 2017

  9. Research article

    Prognostic significance of the total number of harvested lymph nodes for lymph node-negative gastric cancer patients

    The relationship between the number of harvested lymph nodes (HLNs) and prognosis of gastric cancer patients without an involvement of lymph nodes has not been well-evaluated. The objective of this study is to...

    Xin Ji, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia and Jia-Fu Ji

    BMC Cancer 2017 17:558

    Published on: 22 August 2017

  10. Study protocol

    Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) study: design of a randomized controlled trial

    Following esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of esop...

    Jonna K. van Vulpen, Peter D. Siersema, Richard van Hillegersberg, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Eric J. Hazebroek, Camiel Rosman, Carlo C. G. Schippers, Elles Steenhagen, Petra H. M. Peeters and Anne M. May

    BMC Cancer 2017 17:552

    Published on: 18 August 2017

  11. Research article

    Squamous differentiation in patients with superficial bladder urothelial carcinoma is associated with high risk of recurrence and poor survival

    The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor...

    Gang Li, Jianpeng Yu, Hualin Song, Shimiao Zhu, Libin Sun, Zhiqun Shang and Yuanjie Niu

    BMC Cancer 2017 17:530

    Published on: 8 August 2017

  12. Research article

    A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

    Solid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we repor...

    Lina Zhang, Ling Zhuang, Chang Shi, Yanwei Miao, Weisheng Zhang, Qingwei Song, Jianyun Kang, Zhijin Lang, Xuegang Xin, Ailian Liu and Jiani Hu

    BMC Cancer 2017 17:525

    Published on: 7 August 2017

  13. Research article

    Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study

    Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can b...

    Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht and Ulrich Steger

    BMC Cancer 2017 17:522

    Published on: 4 August 2017

  14. Research article

    Complete surgical resection improves outcome in INRG high-risk patients with localized neuroblastoma older than 18 months

    Although several studies have been conducted on the role of surgery in localized neuroblastoma, the impact of surgical timing and extent of primary tumor resection on outcome in high-risk patients remains cont...

    Janina Fischer, Alexandra Pohl, Ruth Volland, Barbara Hero, Martin Dübbers, Grigore Cernaianu, Frank Berthold, Dietrich von Schweinitz and Thorsten Simon

    BMC Cancer 2017 17:520

    Published on: 4 August 2017

  15. Research article

    Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

    To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cerv...

    Jing Li, Ni-ya Ning, Qun-xian Rao, Rong Chen, Li-juan Wang and Zhong-qiu Lin

    BMC Cancer 2017 17:517

    Published on: 3 August 2017

  16. Study protocol

    Alliance for clinical trials in oncology (ALLIANCE) trial A021501: preoperative extended chemotherapy vs. chemotherapy plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the head of the pancreas

    Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for C...

    Matthew H. G. Katz, Fang-Shu Ou, Joseph M. Herman, Syed A. Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H. Schwartz, Wendy Frankel, Eric Collisson, Eugene J. Koay, JoLeen M. Hubbard, James L. Leenstra, Jeffrey Meyerhardt…

    BMC Cancer 2017 17:505

    Published on: 27 July 2017

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