Skip to main content

Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 15

  1. Endoscopic submucosal dissection (ESD) is gaining enormous popularity in the treatment of early gastric cancers (EGCs) in many institutions across the world. However, appropriate selection of candidates for en...

    Authors: Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang and Xi Wang

    Citation: BMC Cancer 2021 21:92

    Content type: Research article

    Published on:

  2. Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine sta...

    Authors: I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma…

    Citation: BMC Cancer 2021 21:90

    Content type: Research article

    Published on:

  3. Immediate breast reconstruction with tissue expander in breast cancer patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate. Postoperative com...

    Authors: Sung Mi Jung, Byung-Joon Jeon, Jinsun Woo, Jai Min Ryu, Se Kyung Lee, Byung-Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jai-Kyong Pyon, Goo-Hyun Mun, Sa Ik Bang and Jeong Eon Lee

    Citation: BMC Cancer 2021 21:88

    Content type: Research article

    Published on:

  4. Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption.

    Authors: Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo and Wei Hua

    Citation: BMC Cancer 2021 21:83

    Content type: Research article

    Published on:

  5. Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. This study aims to examine t...

    Authors: Jieqiong Wen, Wanbin Chen, Yayun Zhu and Pengbo Zhang

    Citation: BMC Cancer 2021 21:81

    Content type: Research article

    Published on:

  6. Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor...

    Authors: Shao-Hao Chen, Long-Yao Xu, Yu-Peng Wu, Zhi-Bin Ke, Peng Huang, Fei Lin, Xiao-Dong Li, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng and Ning Xu

    Citation: BMC Cancer 2021 21:79

    Content type: Research article

    Published on:

  7. The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce a...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler, Lale Umutlu, Maurizio Conti, Pedro Fragoso Costa, Miriam Sraieb and David Kersting

    Citation: BMC Cancer 2021 21:62

    Content type: Research article

    Published on:

  8. Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new ...

    Authors: Matthias E. Meunier, Pascal Blanchet, Yann Neuzillet, Thierry Lebret and Laurent Brureau

    Citation: BMC Cancer 2021 21:61

    Content type: Research article

    Published on:

  9. Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectom...

    Authors: Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying…

    Citation: BMC Cancer 2021 21:56

    Content type: Study protocol

    Published on:

  10. Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, i...

    Authors: Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis…

    Citation: BMC Cancer 2021 21:51

    Content type: Study protocol

    Published on:

  11. This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated with cytoreductive surgery ...

    Authors: Sicheng Zhou, Qiang Feng, Jing Zhang, Haitao Zhou, Zheng Jiang, Zheng Liu, Zhaoxu Zheng, Haipeng Chen, Zheng Wang, Jianwei Liang, Wei Pei, Qian Liu, Zhixiang Zhou and Xishan Wang

    Citation: BMC Cancer 2021 21:41

    Content type: Research article

    Published on:

  12. Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 an...

    Authors: Keisuke Miwa, Eiji Oki, Masanobu Enomoto, Keisuke Ihara, Koji Ando, Fumihiko Fujita, Masahiro Tominaga, Shinichiro Mori, Goro Nakayama, Mototsugu Shimokawa, Hiroshi Saeki, Hideo Baba, Masaki Mori and Yoshito Akagi

    Citation: BMC Cancer 2021 21:23

    Content type: Research article

    Published on:

  13. An accurate intraoperative prediction of lymph node metastatic risk can help surgeons in choosing precise surgical procedures. We aimed to develop and validate nomograms to intraoperatively predict patterns of...

    Authors: Fei Zhao, Rong-Xin Lu, Jin-Yuan Liu, Jun Fan, Hao-Ran Lin, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Fu-Xi Zhen, Jin-Hua Luo and Wei Wang

    Citation: BMC Cancer 2021 21:22

    Content type: Research article

    Published on:

  14. Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. ...

    Authors: Xinxin Wang, Shuo Li, Yihong Sun, Kai Li, Xian Shen, Yingwei Xue, Pin Liang, Guoli Li, Luchuan Chen, Qun Zhao, Guoxin Li, Weihua Fu, Han Liang, Hairong Xin, Jian Suo, Xuedong Fang…

    Citation: BMC Cancer 2021 21:20

    Content type: Study protocol

    Published on:

  15. Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still ...

    Authors: Antonella Vecchiato, Simone Mocellin, Paolo Del Fiore, Giulio Tosti, Paolo A. Ascierto, Maria Teresa Corradin, Vincenzo De Giorgi, Giuseppe Giudice, Paola Queirolo, Caterina Ferreli, Marcella Occelli, Monica Giordano, Giusto Trevisan, Luigi Mascheroni, Alessandro Testori, Romina Spina…

    Citation: BMC Cancer 2021 21:8

    Content type: Research article

    Published on:

  16. Lymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-...

    Authors: Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine and Kenji Sugio

    Citation: BMC Cancer 2020 20:1192

    Content type: Research article

    Published on:

  17. Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relation...

    Authors: Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi and Wataru Takayama

    Citation: BMC Cancer 2020 20:1184

    Content type: Research article

    Published on:

  18. Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment. Howeve...

    Authors: Saumil Datar, Maria Cabanillas, Ramona Dadu, David Ost and Horiana B. Grosu

    Citation: BMC Cancer 2020 20:1181

    Content type: Research article

    Published on:

  19. Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. The aim of this study is therefore ...

    Authors: Shi Yeung Ho and Raymond King Yin Tsang

    Citation: BMC Cancer 2020 20:1172

    Content type: Research article

    Published on:

  20. The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definiti...

    Authors: Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa…

    Citation: BMC Cancer 2020 20:1169

    Content type: Research article

    Published on:

  21. Papillary thyroid cancer (PTC) is unique among cancers in that patient age is a consideration in staging. One of the most important modifications in the 8th Edition of the American Joint Committee on Cancer (A...

    Authors: Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Beata Wojtczak and Jerzy Rudnicki

    Citation: BMC Cancer 2020 20:1166

    Content type: Research article

    Published on:

  22. The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure...

    Authors: Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk and Andrew G. Renehan

    Citation: BMC Cancer 2020 20:1165

    Content type: Research article

    Published on:

  23. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao

    Citation: BMC Cancer 2020 20:1158

    Content type: Research article

    Published on:

  24. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy

    Citation: BMC Cancer 2020 20:1147

    Content type: Research article

    Published on:

  25. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang

    Citation: BMC Cancer 2020 20:1129

    Content type: Research article

    Published on:

  26. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang

    Citation: BMC Cancer 2020 20:1120

    Content type: Research article

    Published on:

  27. There is no currently available treatment for peritoneal metastasis of gastric cancer. This phase II study aimed to evaluate the efficacy and safety of neoadjuvant systemic chemotherapy and hyperthermic intrap...

    Authors: Pengfei Yu, Zeyao Ye, Gaiguo Dai, Yanqiang Zhang, Ling Huang, Yian Du and Xiangdong Cheng

    Citation: BMC Cancer 2020 20:1108

    Content type: Research article

    Published on:

  28. Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a v...

    Authors: Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume and Gro Wiedswang

    Citation: BMC Cancer 2020 20:1107

    Content type: Research article

    Published on:

  29. AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi and Fumio Imamura

    Citation: BMC Cancer 2020 20:1100

    Content type: Research article

    Published on:

  30. The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of un...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi and Hiromasa Ohira

    Citation: BMC Cancer 2020 20:1094

    Content type: Research article

    Published on:

  31. This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic sc...

    Authors: Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima and Yukihide Kanemitsu

    Citation: BMC Cancer 2020 20:1092

    Content type: Research article

    Published on:

  32. This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.

    Authors: Feng Xu, Jian Song, Beizheng Xu, Jiang Wang, Jianjun Mao, Haiyan Liu, Xuanmei Li and Aibing Deng

    Citation: BMC Cancer 2020 20:1089

    Content type: Research article

    Published on:

  33. For patients with multiple myeloma (MM), each additional line of therapy (LOT) is associated with lower response rates, shorter treatment duration and treatment-free intervals, and increased rates of toxicitie...

    Authors: Rafael Fonseca, Saad Z. Usmani, Maneesha Mehra, Mary Slavcev, Jianming He, Sarah Cote, Annette Lam, Jon Ukropec, Eric M. Maiese, Sandhya Nair, Ravi Potluri and Peter M. Voorhees

    Citation: BMC Cancer 2020 20:1087

    Content type: Research article

    Published on:

  34. The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we enginee...

    Authors: Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy and Prabhas V. Moghe

    Citation: BMC Cancer 2020 20:1082

    Content type: Research article

    Published on:

  35. The clinicopathological classification of breast cancer is proposed according to therapeutic purposes. It is simplified and can be conducted easily in clinical practice, and this subtyping undoubtedly contribu...

    Authors: Ming Ni, Xiaoming Zhou, Jingwei Liu, Haiyang Yu, Yuanxiang Gao, Xuexi Zhang and Zhiming Li

    Citation: BMC Cancer 2020 20:1073

    Content type: Research article

    Published on:

  36. Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas and central neurocytomas. The treatment of choice is neurosurgica...

    Authors: A. Kaywan Aftahy, Melanie Barz, Philipp Krauss, Friederike Liesche, Benedikt Wiestler, Stephanie E. Combs, Christoph Straube, Bernhard Meyer and Jens Gempt

    Citation: BMC Cancer 2020 20:1060

    Content type: Research article

    Published on:

  37. The effect of tumor size on account of long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff valu...

    Authors: Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang and Xiangcheng Li

    Citation: BMC Cancer 2020 20:1044

    Content type: Research article

    Published on:

  38. Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of G...

    Authors: Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta and Sachio Fushida

    Citation: BMC Cancer 2020 20:1014

    Content type: Research article

    Published on:

  39. Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of ...

    Authors: Gry Johansen, Pernilla Dahm-Kähler, Christian Staf, Angelique Flöter Rådestad and Kenny A. Rodriguez-Wallberg

    Citation: BMC Cancer 2020 20:1009

    Content type: Research article

    Published on:

  40. Historically, amputation was the primary surgical treatment for osteosarcoma of the extremities; however, with advancements in surgical techniques and chemotherapies limb salvage has replaced amputation as the...

    Authors: Daniel R. Evans, Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer III, Brian E. Brigman and William C. Eward

    Citation: BMC Cancer 2020 20:995

    Content type: Research article

    Published on:

  41. Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical ...

    Authors: Shuxin Sun, Chaobin He, Jun Wang, Xin Huang, Jiali Wu and Shengping Li

    Citation: BMC Cancer 2020 20:981

    Content type: Research article

    Published on:

  42. Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. No comparative study of these tumors for the restric...

    Authors: Dongli Shi, Jun Sun, Liang Ma, Jing Chang and Hongjun Li

    Citation: BMC Cancer 2020 20:977

    Content type: Research article

    Published on:

  43. Brain metastasis represents a major complication with a significantly shorter overall survival of many oncological diseases, in particular of lung cancer, breast cancer and malignant melanoma patients. However...

    Authors: Annalen Bleckmann, Benjamin Kirchner, Manuel Nietert, Micha Peeck, Marko Balkenhol, Daniela Egert, T. Veit Rohde, Tim Beißbarth and Tobias Pukrop

    Citation: BMC Cancer 2020 20:973

    Content type: Research article

    Published on:

  44. Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2...

    Authors: Jian Wang, Yamin Zhang, Lei Liu, Zilin Cui, Rui Shi, Jiancun Hou, Zirong Liu, Long Yang, Lianjiang Wang and Yang Li

    Citation: BMC Cancer 2020 20:966

    Content type: Research article

    Published on:

  45. The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The developme...

    Authors: Sihua Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong…

    Citation: BMC Cancer 2020 20:959

    Content type: Research article

    Published on:

  46. For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. Howe...

    Authors: Shoko Ono, Ayako Nozaki, Kana Matsuda, Emi Takakuwa, Naoya Sakamoto and Hidemichi Watari

    Citation: BMC Cancer 2020 20:955

    Content type: Research article

    Published on:

  47. Preoperative breast magnetic resonance imaging (MRI) provides more information than mammography and ultrasonography for determining the surgical plan for patients with breast cancer. This study aimed to determ...

    Authors: Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Chan Sub Park, Ryu Kyung Lee, Hye Jung Kim, Won Hwa Kim and Ho Yong Park

    Citation: BMC Cancer 2020 20:934

    Content type: Research article

    Published on: