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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 6 of 15

  1. Content type: Research article

    5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, and Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer. Since data showing the influ...

    Authors: Stefan Munker, Michael Gerken, Petra Fest, Claudia Ott, Elisabeth Schnoy, Stefan Fichtner-Feigl, Philipp Wiggermann, Martin Vogelhuber, Wolfgang Herr, Christian Stroszczynski, Hans Jürgen Schlitt, Matthias Evert, Michael Reng, Monika Klinkhammer-Schalke and Andreas Teufel

    Citation: BMC Cancer 2018 18:455

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  2. Content type: Research article

    The objective of study was to determine the effect of anthracycline dose reduction and chemotherapy delays on 5-year overall survival in patients with stage I-III breast cancer, to establish the impact of mole...

    Authors: Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite and Elona Juozaityte

    Citation: BMC Cancer 2018 18:453

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  3. Content type: Research article

    To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with small hepatocellular carcinoma(sHCC) who were ineligible for surgery or ablation therapies.

    Authors: Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu and Xuezhang Duan

    Citation: BMC Cancer 2018 18:451

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  4. Content type: Research article

    Some patients develop recurrence after curative resection and adjuvant chemotherapy. S-1, an oral fluoropyrimidine, is one of the standard regimens in adjuvant chemotherapy, and is also used in first-line trea...

    Authors: Seiji Ito, Yasuo Ohashi and Mitsuru Sasako

    Citation: BMC Cancer 2018 18:449

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  5. Content type: Research article

    To identify the incidence, recurrence pattern and prognosis of brain metastases (BM) among women with metastatic triple negative breast cancer (mTNBC) treated consecutively at a single institution during a 7-y...

    Authors: Jia Jin, Yu Gao, Jian Zhang, Leiping Wang, Biyun Wang, Jun Cao, Zhimin Shao and Zhonghua Wang

    Citation: BMC Cancer 2018 18:446

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  6. Content type: Research article

    Volumetric-modulated arc therapy (VMAT) is a highly sophisticated linear accelerator-based treatment method, and allows dose rate-changing intensity modulation with gantry rotation. We report our clinical expe...

    Authors: Yuri Jeong, Jinhong Jung, Byungchul Cho, Jungwon Kwak, Chiyoung Jeong, Jong Hoon Kim, Jin-hong Park, So Yeon Kim, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee and Sang Min Yoon

    Citation: BMC Cancer 2018 18:416

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  7. Content type: Case report

    SMARCB1 (INI1) is a tumor-suppressor gene located at 22q11.2. Loss of SMARCB1 protein expression has been reported to be associated with atypical teratoid/rhabdoid tumors and malignant rhabdoid tumors of the kidn...

    Authors: Kazushi Yoshida, Yutaka Fujiwara, Yasushi Goto, Takashi Kohno, Akihiko Yoshida, Koji Tsuta and Yuichiro Ohe

    Citation: BMC Cancer 2018 18:398

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  8. Content type: Case report

    Treatment of recurrent nasopharyngeal carcinoma is a challenging clinical problem. We report the case of a 46 year old male showing excellent response and signs of immunostimulation following re-re-irradiation...

    Authors: T. Finazzi, T. Rordorf, K. Ikenberg, G. F. Huber, M. Guckenberger and H. I. Garcia Schueler

    Citation: BMC Cancer 2018 18:395

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  9. Content type: Research article

    Sorafenib and transarterial chemoembolization (TACE) might both provide survival benefit for advanced hepatocellular carcinoma (HCC). Adopting either as a first-line therapy carries major cost and resource imp...

    Authors: Shuling Chen, Zhenwei Peng, Mengchao Wei, Weifeng Liu, Zihao Dai, Haibo Wang, Jie Mei, Mingfong Cheong, Hanmei Zhang and Ming Kuang

    Citation: BMC Cancer 2018 18:392

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  10. Content type: Research article

    Recent studies have reported a relationship between prognosis and neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck cancer (HNC). As the results are still controversial, we conducted a meta-a...

    Authors: Yalian Yu, Hongbo Wang, Aihui Yan, Hailong Wang, Xinyao Li, Jiangtao Liu and Wei Li

    Citation: BMC Cancer 2018 18:383

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  11. Content type: Research article

    Knowledge about disease and treatment is necessary before patients can consent to treatment. One of the few established instruments for evaluating whether sufficient information has been provided, is the EORTC...

    Authors: Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa and Kari Sand

    Citation: BMC Cancer 2018 18:381

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  12. Content type: Research article

    Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versu...

    Authors: Daniel M. Girardi, Mariana A. de Lima, Gabriel C. B. Pereira, Marcelo V. Negrão, Rossana V. M. López, Fernanda C. Capareli, Jorge Sabbaga and Paulo Marcelo G. Hoff

    Citation: BMC Cancer 2018 18:378

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  13. Content type: Research article

    A randomized trial demonstrated that capecitabine is at least as effective as fluorouracil in the adjuvant treatment of patients with locally advanced rectal cancer. However, not all patients receive all plann...

    Authors: Flavius Sandra-Petrescu, Florian Herrle, Iris Burkholder, Peter Kienle and Ralf-Dieter Hofheinz

    Citation: BMC Cancer 2018 18:369

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  14. Content type: Study protocol

    Treatment of chronic myeloid leukemia with a tyrosine kinase inhibitor (TKI) offers significant improvements over previous treatments in terms of survival and toxicity yet nevertheless is associated with reduc...

    Authors: Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang, Jerald P. Radich, Vivian G. Oehler, Javier Pinilla-Ibarz, Michael W. N. Deininger, Li Lin, Richard A. Larson, Michael J. Mauro, Joseph O. Moore, Ellen K. Ritchie, Neil P. Shah, Richard T. Silver, Martha Wadleigh…

    Citation: BMC Cancer 2018 18:359

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  15. Content type: Research article

    Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancers and is associated with a poor prognosis. Afatinib is an irreversible ErbB family blocker recommended in clinical guidelines as a first-li...

    Authors: Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu and Kwong Ng

    Citation: BMC Cancer 2018 18:352

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  16. Content type: Debate

    Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of spec...

    Authors: Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina and Paolo Pedrazzoli

    Citation: BMC Cancer 2018 18:337

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  17. Content type: Research article

    In this prospective non-interventional study, the effectiveness and tolerability of erlotinib in elderly patients with non-small-cell lung cancer (NSCLC) after ≥1 platinum-based chemotherapy were assessed.

    Authors: Wolfgang M. Brueckl, H. Jost Achenbach, Joachim H. Ficker and Wolfgang Schuette

    Citation: BMC Cancer 2018 18:333

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  18. Content type: Research article

    Concurrent chemoradiotherapy followed by adjuvant chemotherapy (CCRT-AC) is currently recommended as the standard treatment for locally advanced nasopharyngeal carcinoma (LA-NPC). Neoadjuvant chemotherapy foll...

    Authors: Jiraporn Setakornnukul and Kullathorn Thephamongkhol

    Citation: BMC Cancer 2018 18:329

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  19. Content type: Research article

    HER2 mutation has been found to be an oncogenic driver gene in non-small cell lung cancers(NSCLC) and HER2-directed therapies have shown promising results in this unique population, while little is known about it...

    Authors: Yan Wang, Shijia Zhang, Fengying Wu, Jing Zhao, Xuefei Li, Chao Zhao, Shengxiang Ren and Caicun Zhou

    Citation: BMC Cancer 2018 18:326

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  20. Content type: Research article

    Little is known about the prognostic difference of anti-EGFR therapy, cetuximab (CTX) or nimotuzumab (NTZ), concurrently with induction chemotherapy (IC, investigational arm) or RT (control arm) for patients w...

    Authors: Hao Peng, Ling-Long Tang, Xu Liu, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun and Jun Ma

    Citation: BMC Cancer 2018 18:323

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  21. Content type: Case report

    We report the successful treatment of the patient with osimertinib 80 mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGF...

    Authors: Isa Mambetsariev, Lalit Vora, Kim Wai Yu and Ravi Salgia

    Citation: BMC Cancer 2018 18:314

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  22. Content type: Case report

    Everolimus was recently approved for the treatment of neuroendocrine tumors. However, its efficacy and tolerability in hemodialysis patients with end-stage renal disease is not established.

    Authors: M. P. Brizzi, A. La Salvia, M. Tampellini, C. Sonetto, M. Volante and G. V. Scagliotti

    Citation: BMC Cancer 2018 18:311

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  23. Content type: Research article

    Prediction of the outcome of sorafenib therapy using biomarkers is an unmet clinical need in patients with advanced hepatocellular carcinoma (HCC). The aim was to develop and validate a biomarker-based model f...

    Authors: Hwi Young Kim, Dong Hyeon Lee, Jeong-Hoon Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim and Jung-Hwan Yoon

    Citation: BMC Cancer 2018 18:307

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  24. Content type: Research article

    The expression of circular RNA (circRNA) may affect tumor progression. However, there have been no systemic meta-analysis for cancer diagnosis by using circRNAs in clinical till now. Herein, we aimed to collec...

    Authors: Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren and Huijian Wu

    Citation: BMC Cancer 2018 18:303

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  25. Content type: Research article

    In patients with metastatic renal cell cancer, based on limited evidence, increased sunitinib exposure is associated with better outcome. The survival and toxicity data of patients receiving individualized dos...

    Authors: Anikó Maráz, Adrienn Cserháti, Gabriella Uhercsák, Éva Szilágyi, Zoltán Varga, János Révész, Renáta Kószó, Linda Varga and Zsuzsanna Kahán

    Citation: BMC Cancer 2018 18:296

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  26. Content type: Research article

    Trastuzumab (Herceptin® [H]) is the standard of care for HER2-positive locally advanced/metastatic breast cancer and gastric/gastroesophageal junction (GEJ) cancer. However, there is a paucity of data availabl...

    Authors: Volkmar Müller, Michael Clemens, Jacek Jassem, Nedal Al-Sakaff, Petra Auclair, Eveline Nüesch, Debbie Holloway, Mona Shing and Yung-Jue Bang

    Citation: BMC Cancer 2018 18:295

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  27. Content type: Research article

    To compare the prevalence of nephrotoxicity between patients with a solitary-functioning kidney versus those with bilateral-functioning kidneys during the administration of cisplatin-based chemotherapy for adv...

    Authors: Takamitsu Inoue, Jun Miyazaki, Daishi Ichioka, Shintaro Narita, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Yoshiyuki Matsui, Keiko Fujie, Tomonori Habuchi and Hiroyuki Nishiyama

    Citation: BMC Cancer 2018 18:290

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  28. Content type: Research article

    The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and sum...

    Authors: D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang and X. Y. Huang

    Citation: BMC Cancer 2018 18:281

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  29. Content type: Research article

    Mainly because of the diversity of clinical presentations, diagnostic delays in lymphoma can be excessive. The time spent in primary care before referral to the specialist may be relatively short compared with...

    Authors: Xavier Bosch, Carmen Sanclemente-Ansó, Ona Escoda, Esther Monclús, Jonathan Franco-Vanegas, Pedro Moreno, Mar Guerra-García, Neus Guasch and Alfons López-Soto

    Citation: BMC Cancer 2018 18:276

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  30. Content type: Research article

    Here we assessed the influence of androgen deprivation therapy (ADT) during and/or after post-prostatectomy radiotherapy (RT) on biochemical recurrence (BCR) and radiographic progression in patients with prost...

    Authors: Myong Kim, Cheryn Song, In Gab Jeong, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim and Hanjong Ahn

    Citation: BMC Cancer 2018 18:271

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  31. Content type: Research article

    Several systemic treatments have been shown to increase survival for patients with metastatic castration-resistant prostate cancer. This study sought to characterize variation in use of the six “focus drugs” (...

    Authors: Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin and Bhramar Mukherjee

    Citation: BMC Cancer 2018 18:258

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  32. Content type: Research article

    Oxaliplatin is a platinum derivative that has shown efficacy in advanced hepatocellular carcinoma. S-1 is an oral fluoropyrimidine that has substituted for 5-fluorouracil in many cancers. This was a multicente...

    Authors: Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im and Tae-You Kim

    Citation: BMC Cancer 2018 18:252

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  33. Content type: Research article

    Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

    Authors: Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao

    Citation: BMC Cancer 2018 18:251

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  34. Content type: Case report

    Immune checkpoint inhibitors (ICPIs) are being investigated in clinical trials for patients with glioblastoma. While these therapies hold great promise, management of the patients receiving such treatment can ...

    Authors: Surabhi Ranjan, Martha Quezado, Nancy Garren, Lisa Boris, Christine Siegel, Osorio Lopes Abath Neto, Brett J. Theeler, Deric M. Park, Edjah Nduom, Kareem A. Zaghloul, Mark R. Gilbert and Jing Wu

    Citation: BMC Cancer 2018 18:239

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  35. Content type: Research article

    The immune system has a known role in the aetiology, progression and final treatment outcome of oral squamous cell cancers. The aim of this study was to evaluate the influence of radical surgery and radiothera...

    Authors: Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik and Nataša Ihan Hren

    Citation: BMC Cancer 2018 18:235

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  36. Content type: Research article

    There is no consensus regarding the optimal time to initiate adjuvant chemotherapy after surgery for stage III colon cancer, and the relevant postoperative complications that cause delays in adjuvant chemother...

    Authors: Peng Gao, Xuan-zhang Huang, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Yu Sun, Yu-meng Jiang and Zhen-ning Wang

    Citation: BMC Cancer 2018 18:234

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  37. Content type: Study protocol

    Gamma Knife radiosurgery (GKRS) is increasingly applied in patients with multiple brain metastases and is expected to have less adverse effects in cognitive functioning than whole brain radiation therapy (WBRT...

    Authors: Wietske C. M. Schimmel, Eline Verhaak, Patrick E. J. Hanssens, Karin Gehring and Margriet M. Sitskoorn

    Citation: BMC Cancer 2018 18:218

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  38. Content type: Research article

    Patient characteristics and survival outcomes in randomized trials may be different from those in real-life clinical practice. The objective of this study was to describe treatment pathways, safety, drug costs...

    Authors: Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne and Isabelle Durand-Zaleski

    Citation: BMC Cancer 2018 18:214

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  39. Content type: Case report

    Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence and distant metastasis, and poor prognosis. There are no established treatment guidelines for PHA.

    Authors: Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi and Yao Wang

    Citation: BMC Cancer 2018 18:212

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  40. Content type: Research article

    Survival advantage following trans-arterial chemoembolization (TACE) is variable in patients with hepatocellular carcinoma (HCC). We combined pre-TACE radiologic features to derive a novel prognostic signature...

    Authors: David J. Pinato, Madhava Pai, Isabella Reccia, Markand Patel, Alexandros Giakoustidis, Georgios Karamanakos, Azelea Rushd, Shiraz Jamshaid, Alberto Oldani, Glenda Grossi, Mario Pirisi, Paul Tait and Rohini Sharma

    Citation: BMC Cancer 2018 18:211

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  41. Content type: Research article

    To evaluate the prevalence of metastatic tumors involving the myocardium and study their presentation in order to increase awareness to their existence.

    Authors: Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack and Yehuda Adler

    Citation: BMC Cancer 2018 18:202

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  42. Content type: Research article

    Radiological monitoring of malignant pleural mesothelioma (MPM) using modified RECIST criteria is limited by low sensitivity and inter-observer variability. Serial serum mesothelin measurement has shown utilit...

    Authors: Duneesha de Fonseka, David T. Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo and Nick A. Maskell

    Citation: BMC Cancer 2018 18:199

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  43. Content type: Study protocol

    The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade ≥ 2 skin toxicity in patients receiving radiotherapy alone or radiochemotherapy for locally a...

    Authors: Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl and Dirk Rades

    Citation: BMC Cancer 2018 18:197

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  44. Content type: Research article

    RECORD-4 assessed everolimus in patients with metastatic renal cell carcinoma (mRCC) who progressed after 1 prior anti-vascular endothelial growth factor (VEGF) or cytokine and reinforced the clinical benefit ...

    Authors: Lin Yang, Anna Alyasova, Dingwei Ye, Antonia Ridolfi, Luca Dezzani and Robert J. Motzer

    Citation: BMC Cancer 2018 18:195

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  45. Content type: Research article

    Bladder cancer is the 7th cause of death from cancer in men and 10th in women. Metastatic patients have a poor prognosis with a median overall survival of 14 months. Until recently, vinflunine was the only sec...

    Authors: Marina Pulido, Guilhem Roubaud, Anne-Laure Cazeau, Hakim Mahammedi, Lionel Vedrine, Florence Joly, Loic Mourey, Christian Pfister, Alejandro Goberna, Barbara Lortal, Carine Bellera, Philippe Pourquier and Nadine Houédé

    Citation: BMC Cancer 2018 18:194

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