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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 4 of 22

  1. The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring...

    Authors: Joon Yeul Nam, A Reum Choe, Dong Hyun Sinn, Jeong-Hoon Lee, Hwi Young Kim, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong Min Lee, Jin Wook Chung, Sun Young Choi, Jeong Kyong Lee, Seung Yon Baek, Hye Ah Lee, Tae Hun Kim and Kwon Yoo

    Citation: BMC Cancer 2020 20:504

    Content type: Research article

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  2. The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among pat...

    Authors: Efrat Markus, Svetlana Trestman, Yael Cohen, Yoel Angel, Yael Sofer, Moshe Mittelman, Irit Avivi, Naftali Stern and Elena Izkhakov

    Citation: BMC Cancer 2020 20:489

    Content type: Research article

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  3. There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasi...

    Authors: Espen Thiis-Evensen, Amalie Christine Poole, Hong-Thien Thi Nguyen and Jon Sponheim

    Citation: BMC Cancer 2020 20:466

    Content type: Research article

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  4. Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2–3 years. A subgroup of those patients with mC...

    Authors: Charlien Berghen, Steven Joniau, Kato Rans, Gaëtan Devos, Kenneth Poels, Koen Slabbaert, Herlinde Dumez, Maarten Albersen, Karolien Goffin, Karin Haustermans and Gert De Meerleer

    Citation: BMC Cancer 2020 20:457

    Content type: Study protocol

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  5. As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an ad...

    Authors: Kristiina Vuolukka, Päivi Auvinen, Jan-Erik Palmgren, Sirpa Aaltomaa and Vesa Kataja

    Citation: BMC Cancer 2020 20:453

    Content type: Research article

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  6. There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and t...

    Authors: Masashi Sawada, Akiyoshi Kasuga, Takafumi Mie, Takaaki Furukawa, Takanobu Taniguchi, Koshiro Fukuda, Yuto Yamada, Tsuyoshi Takeda, Ryo Kanata, Masato Matsuyama, Takashi Sasaki, Masato Ozaka and Naoki Sasahira

    Citation: BMC Cancer 2020 20:449

    Content type: Research article

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  7. The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the ...

    Authors: Kerstin A. Kessel, Rebekka C. E. Grosser, Kim Melanie Kraus, Hans Hoffmann, Markus Oechsner and Stephanie E. Combs

    Citation: BMC Cancer 2020 20:442

    Content type: Research article

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  8. For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be adminis...

    Authors: Hong-tao Guo, Xue-han Bi, Ting Lei, Xiao Lv, Guang Yao, Yao Chen and Chang Liu

    Citation: BMC Cancer 2020 20:441

    Content type: Research article

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  9. Systemic inflammation and cachexia are associated with adverse clinical outcomes in diffuse large B-cell lymphoma (DLBCL). The Geriatric Nutritional Risk Index (GNRI) is one of the main parameters used to asse...

    Authors: Se-Il Go, Hoon-Gu Kim, Myoung Hee Kang, Sungwoo Park and Gyeong-Won Lee

    Citation: BMC Cancer 2020 20:439

    Content type: Research article

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  10. Langerhans Cell Histiocytosis (LCH) is a rare disease puzzling both children and adults, however outcome of adult patients is unfavorable. This prospective interventional trial aims to test the efficacy and sa...

    Authors: Xiao Han, Mingqi Ouyang, Minghui Duan, Wei Zhang, Tienan Zhu, Jian Li, Shujie Wang and Daobin Zhou

    Citation: BMC Cancer 2020 20:433

    Content type: Research article

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  11. We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.

    Authors: Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen, Yong-Ming Chen, Guo-Ming Chen, Xiao-Jiang Chen, Tian-Qi Luo, Shu-Man Li, Jin-Ling Duan, Yun Wang and Yuan-Fang Li

    Citation: BMC Cancer 2020 20:421

    Content type: Research article

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  12. Elderly patients are underrepresented in clinical study where combined endocrine strategies were compared to endocrine therapy (ET) in hormone receptors positive, HER2 negative, metastatic breast cancer. The r...

    Authors: Claudia Omarini, Federico Piacentini, Isabella Sperduti, Monica Barbolini, Chrystel Isca, Angela Toss, Laura Cortesi, Elena Barbieri, Massimo Dominici and Luca Moscetti

    Citation: BMC Cancer 2020 20:418

    Content type: Research article

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  13. Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this m...

    Authors: A. De Bruycker, A. Spiessens, P. Dirix, N. Koutsouvelis, I. Semac, N. Liefhooghe, A. Gomez-Iturriaga, W. Everaerts, F. Otte, A. Papachristofilou, M. Scorsetti, M. Shelan, S. Siva, F. Ameye, M. Guckenberger, R. Heikkilä…

    Citation: BMC Cancer 2020 20:406

    Content type: Study protocol

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  14. Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved t...

    Authors: Goda G. Kalinauskaite, Ingeborg I. Tinhofer, Markus M. Kufeld, Anne A. Kluge, Arne A. Grün, Volker V. Budach, Carolin C. Senger and Carmen C. Stromberger

    Citation: BMC Cancer 2020 20:404

    Content type: Research article

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  15. Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife®) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). Additionally we wanted to eval...

    Authors: Patrick Berkovic, Akos Gulyban, Gilles Defraene, Laurie Swenen, David Dechambre, Paul Viet Nguyen, Nicolas Jansen, Carole Mievis, Pierre Lovinfosse, Levente Janvary, Maarten Lambrecht and Gert De Meerleer

    Citation: BMC Cancer 2020 20:402

    Content type: Research article

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  16. Induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) has been recommended as the first-line therapy for locoregional nasopharyngeal carcinoma (NPC). Due to the different chemotherapeut...

    Authors: Bi-Cheng Wang, Bo-Ya Xiao, Guo-He Lin, Chang Wang and Quentin Liu

    Citation: BMC Cancer 2020 20:393

    Content type: Research article

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  17. A recent randomized phase II trial evaluated stereotactic ablative radiotherapy (SABR) in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that...

    Authors: Robert Olson, Lindsay Mathews, Mitchell Liu, Devin Schellenberg, Benjamin Mou, Tanya Berrang, Stephen Harrow, Rohann J. M. Correa, Vasudeva Bhat, Howard Pai, Islam Mohamed, Stacy Miller, Famke Schneiders, Joanna Laba, Derek Wilke, Sashendra Senthi…

    Citation: BMC Cancer 2020 20:380

    Content type: Study protocol

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  18. Patients with activating epidermal growth factor receptor (EGFR) mutations are highly responsive to EGFR-tyrosine kinase inhibitors (TKIs). However, it has been reported that approximately 15–30% of patients trea...

    Authors: Kazushige Wakuda, Hiroyuki Yamaguchi, Hirotsugu Kenmotsu, Minoru Fukuda, Masafumi Takeshita, Takayuki Suetsugu, Keisuke Kirita, Noriyuki Ebi, Osamu Hataji, Satoru Miura, Kenji Chibana, Isamu Okamoto, Kenichi Yoshimura, Kazuhiko Nakagawa, Nobuyuki Yamamoto and Kenji Sugio

    Citation: BMC Cancer 2020 20:370

    Content type: Study protocol

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  19. A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen l...

    Authors: Ann-Kathrin Oehus, Stephanie G. C. Kroeze, Nina-Sophie Schmidt-Hegemann, Marco M. E. Vogel, Simon Kirste, Jessica Becker, Irene A. Burger, Thorsten Derlin, Peter Bartenstein, Matthias Eiber, Michael Mix, Christian la Fougère, Claus Belka, Stephanie E. Combs, Anca-Ligia Grosu, Arndt-Christian Müller…

    Citation: BMC Cancer 2020 20:362

    Content type: Research article

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  20. This study aimed to evaluate the efficacy and the safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) pa...

    Authors: Yusuke Kitagawa, Hiroki Osumi, Eiji Shinozaki, Yumiko Ota, Izuma Nakayama, Takeshi Suzuki, Takeru Wakatsuki, Mariko Ogura, Akira Ooki, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin and Kensei Yamaguchi

    Citation: BMC Cancer 2020 20:358

    Content type: Research article

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  21. Tumor recurrence and metastasis occur at a high rate in patients with colon cancer. Identification of effective strategies for the treatment of colon cancer is critical. Recently, poly (lactic-co-glycolic acid...

    Authors: Pingping Wu, Qing Zhou, Huayun Zhu, Yan Zhuang and Jun Bao

    Citation: BMC Cancer 2020 20:354

    Content type: Research article

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  22. High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood st...

    Authors: Sandra Sauer, Petra Pavel, Anita Schmitt, Martin Cremer, Mark Kriegsmann, Thomas Bruckner, Karin Jordan, Patrick Wuchter, Carsten Müller-Tidow and Katharina Kriegsmann

    Citation: BMC Cancer 2020 20:353

    Content type: Research article

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  24. Planar-based measurements of lesions in metastatic melanoma have limitations in estimating tumor burden of a patient and in predicting response to treatment. Volumetric imaging might add predictive value to Re...

    Authors: Arwa Ali, Monica Dumbrava, Kylie Riddell, Nina Stewart, Robyn Ward, Ahmed K. Ibrahim and Melvin Chin

    Citation: BMC Cancer 2020 20:342

    Content type: Research article

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  25. Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes ...

    Authors: Sadayuki Kawai, Naoki Fukuda, Shun Yamamoto, Seiichiro Mitani, Katsuhiro Omae, Takeru Wakatsuki, Ken Kato, Shigenori Kadowaki, Daisuke Takahari, Narikazu Boku, Kei Muro and Nozomu Machida

    Citation: BMC Cancer 2020 20:338

    Content type: Research article

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  26. The standard treatment for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy (CRT) using 5-FU plus cisplatin. However, complete response (CR)...

    Authors: Hideaki Bando, Daisuke Kotani, Takahiro Tsushima, Hiroki Hara, Shigenori Kadowaki, Ken Kato, Keisho Chin, Kensei Yamaguchi, Shun-ichiro Kageyama, Hidehiro Hojo, Masaki Nakamura, Hidenobu Tachibana, Masashi Wakabayashi, Miki Fukutani, Yosuke Togashi, Nozomu Fuse…

    Citation: BMC Cancer 2020 20:336

    Content type: Study protocol

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  27. Unplanned hospitalization during cancer treatment is costly, can disrupt treatment, and affect patient quality of life. However, incidence and risks factors for hospitalization during lung cancer radiotherapy ...

    Authors: Sarah Z. Hazell, Nicholas Mai, Wei Fu, Chen Hu, Cole Friedes, Alex Negron, Khinh Ranh Voong, Josephine L. Feliciano, Peijin Han, Samantha Myers, Todd R. McNutt and Russell K. Hales

    Citation: BMC Cancer 2020 20:334

    Content type: Research article

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  28. The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who r...

    Authors: Kang Qin, Helei Hou, Yu Liang and Xiaochun Zhang

    Citation: BMC Cancer 2020 20:328

    Content type: Research article

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  29. In this retrospective study, we evaluated the biochemical recurrence rate, metastatic disease progression, and prostate cancer-specific and overall survival in patients curatively treated with external beam ra...

    Authors: Miikka Lehtonen, Lauri Heiskanen, Petri Reinikainen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: BMC Cancer 2020 20:324

    Content type: Research article

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  30. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficie...

    Authors: Tomoyuki Nakajima, Takeshi Uehara, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Maruyama and Hiroyoshi Ota

    Citation: BMC Cancer 2020 20:319

    Content type: Research article

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  31. Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of...

    Authors: Maria Paola Ciliberti, Roberta Carbonara, Antonietta Grillo, Anna Maria Leo, Ivan Lolli, Carmela Ostuni, Laura Troiani, Barbara Turi, Simona Vallarelli and Angela Sardaro

    Citation: BMC Cancer 2020 20:311

    Content type: Case report

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  32. Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic ...

    Authors: Sofie Olsson Hau, Alexandra Petersson, Björn Nodin, Emelie Karnevi, Karolina Boman, Caroline Williamsson, Jakob Eberhard, Karin Leandersson, David Gisselsson, Margareta Heby and Karin Jirström

    Citation: BMC Cancer 2020 20:308

    Content type: Study protocol

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  33. For novel cancer treatments, effectiveness in clinical practice is not always aligned with clinical efficacy results. As such it is important to understand a treatment’s real-world effectiveness. We examined r...

    Authors: Wei Fang Dai, Jaclyn M. Beca, Ruth Croxford, Wanrudee Isaranawatchai, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Timothy P. Hanna and Kelvin K.W. Chan

    Citation: BMC Cancer 2020 20:304

    Content type: Research article

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  34. To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy ...

    Authors: Dongqing Wang, Shui Yu, Limin Zhai, Jin Xu and Baosheng Li

    Citation: BMC Cancer 2020 20:283

    Content type: Research article

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  35. There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite the sizable percentage of these patients in clinical practice. This stu...

    Authors: Nan Bi, Lipin Liu, Jun Liang, Shixiu Wu, Ming Chen, Changxing Lv, Lujun Zhao, Anhui Shi, Wei Jiang, Yaping Xu, Zongmei Zhou, Jingbo Wang, Wenqing Wang, Dongfu Chen, Zhouguang Hui, Jima Lv…

    Citation: BMC Cancer 2020 20:278

    Content type: Research article

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  36. To evaluate the value of new therapies for non-small cell lung cancer (NSCLC), it is necessary to understand overall survival (OS) rates associated with previous standard therapies and how these rates have evo...

    Authors: Ryan N. Hansen, Yiduo Zhang, Brian Seal, Kellie Ryan, Candice Yong, Annie Darilay and Scott D. Ramsey

    Citation: BMC Cancer 2020 20:276

    Content type: Research article

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  37. Combination of gemcitabine and nab-paclitaxel has superior clinical efficacy than gemcitabine alone. Nevertheless, health-related quality of life. (QoL) associated with this combination therapy when administer...

    Authors: Suayib Yalcin, Faysal Dane, Berna Oksuzoglu, Nuriye Yildirim Ozdemir, Abdurrahman Isikdogan, Metin Ozkan, Guzin Gonullu Demirag, Hasan Senol Coskun, Bulent Karabulut, Turkkan Evrensel, Mehmet Ali Ustaoglu, Feyyaz Ozdemir, Hande Turna, Tugba Yavuzsen, Faruk Aykan, Alper Sevinc…

    Citation: BMC Cancer 2020 20:259

    Content type: Research article

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  38. The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.

    Authors: Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li…

    Citation: BMC Cancer 2020 20:255

    Content type: Research article

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  40. Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this d...

    Authors: Fangbin Zhou, Donge Tang, Yong Xu, Huiyan He, Yan Wu, Liewen Lin, Jun Dong, Wenyong Tan and Yong Dai

    Citation: BMC Cancer 2020 20:242

    Content type: Research article

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  41. Prophylactic cranial irradiation (PCI) is a current standard of care after confirmed response to radical chemoradiotherapy for limited disease small cell lung cancer (LD-SCLC). This standard is mostly based on...

    Authors: Sergiusz Nawrocki and Anna Sugajska

    Citation: BMC Cancer 2020 20:231

    Content type: Study protocol

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  42. As the number of PET/CT scanners increases and FDG PET/CT becomes a common imaging modality for oncology, the demands for automated detection systems on artificial intelligence (AI) to prevent human oversight ...

    Authors: Keisuke Kawauchi, Sho Furuya, Kenji Hirata, Chietsugu Katoh, Osamu Manabe, Kentaro Kobayashi, Shiro Watanabe and Tohru Shiga

    Citation: BMC Cancer 2020 20:227

    Content type: Research article

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  43. Even though treatment modalities such as adjuvant systemic radio-chemotherapy and neoadjuvant chemotherapy (NAC) have individually have improved overall survival (OS) and progression-free survival (PFS) rates ...

    Authors: Maneesh Kumarsing Beeharry, Zhen-Tian Ni, Zhong Yin Yang, Ya Nan Zheng, Run Hua Feng, Wen-Tao Liu, Chao Yan, Xue Xin Yao, Chen Li, Min Yan and Zheng-Gang Zhu

    Citation: BMC Cancer 2020 20:224

    Content type: Study protocol

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  44. To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases ...

    Authors: Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu and Qiang Wei

    Citation: BMC Cancer 2020 20:220

    Content type: Research article

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  45. Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and progno...

    Authors: Takehiro Tozuka, Satoru Kitazono, Hiroaki Sakamoto, Hiroshi Yoshida, Yoshiaki Amino, Shinya Uematsu, Takahiro Yoshizawa, Tsukasa Hasegawa, Ken Uchibori, Noriko Yanagitani, Atsushi Horiike, Takeshi Horai, Masahiro Seike, Akihiko Gemma and Makoto Nishio

    Citation: BMC Cancer 2020 20:207

    Content type: Research article

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  46. The current study aimed to evaluate the outcomes of patients with unresectable non-metastatic locally advanced pancreatic adenocarcinoma (LAPA) who did not benefit from resection considering the treatment stra...

    Authors: Jonathan Garnier, Jacques Ewald, Ugo Marchese, Marine Gilabert, Simon Launay, Laurence Moureau-Zabotto, Flora Poizat, Marc Giovannini, Jean-Robert Delpero and Olivier Turrini

    Citation: BMC Cancer 2020 20:203

    Content type: Research article

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  47. Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (...

    Authors: Justina Ucheojor Onwuka, Akinkunmi Paul Okekunle, Olaniyi Matthew Olutola, Onoja Matthew Akpa and Rennan Feng

    Citation: BMC Cancer 2020 20:200

    Content type: Research article

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  48. Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ip...

    Authors: Nicholas F. Brown, Stasya M. Ng, Claire Brooks, Tim Coutts, Jane Holmes, Corran Roberts, Leena Elhussein, Peter Hoskin, Tim Maughan, Sarah Blagden and Paul Mulholland

    Citation: BMC Cancer 2020 20:198

    Content type: Study protocol

    Published on:

  49. To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for l...

    Authors: Katherine Meng, Jeremy Tey, Francis Cho Hao Ho, Hira Asim and Timothy Cheo

    Citation: BMC Cancer 2020 20:193

    Content type: Research article

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  50. This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients.

    Authors: Ping Liu, Lihong Lin, Yanxiang Kong, Zhifeng Huo, Lin Zhu, Xiaonong Bin, Jinghe Lang and Chunlin Chen

    Citation: BMC Cancer 2020 20:189

    Content type: Research article

    Published on:

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