Previous studies on cervical cancer reported a worse outcome for adenocarcinoma (AC) compared with squamous cell carcinoma (SCC). Nevertheless, standard treatment remains identical. Insight in the impact of hi...
Authors: Karen Couvreur, Eline Naert, Emiel De Jaeghere, Philippe Tummers, Amin Makar, Pieter De Visschere, Mieke Van Bockstal, Jo Van Dorpe, Wilfried De Neve, Hannelore Denys and Katrien Vandecasteele
The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who ...
Authors: Seong Eun Kim, Younggon Jung, Tae Hoon Oh, Uh Jin Kim, Seung-Ji Kang, Hee-Chang Jang, Kyung-Hwa Park, Kyung-Hwa Lee and Sook In Jung
The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response a...
Authors: Ping Yu, Mingyi Zhou, Jinglei Qu, Lingyu Fu, Xuedan Li, Ruimei Cai, Bo Jin, Yuee Teng, Jing Liu, Jing Shi and Jingdong Zhang
Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved ...
Authors: Gabriel Rinnerthaler, Simon Peter Gampenrieder, Andreas Petzer, Sonja Burgstaller, David Fuchs, Dieter Rossmann, Marija Balic, Daniel Egle, Holger Rumpold, Christian F. Singer, Rupert Bartsch, Edgar Petru, Thomas Melchardt, Hanno Ulmer, Brigitte Mlineritsch and Richard Greil
Among non-small cell lung cancer (NSCLC) patients with acquired T790 M mutation resistance to first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), 71% are likely to benefit f...
Authors: Lin-Peng Zheng, Li-Ying Chen, Xing-Yun Liao, Zi-Han Xu, Zheng-Tang Chen and Jian-Guo Sun
The optimal timing of radiotherapy (RT) with respect to surgery remains controversial for locally advanced non-small cell lung cancer (LA NSCLC) undergoing surgery and the long-term effect of neoadjuvant RT, a...
Authors: Xinyu Wang, Chang Yin, Shaofei Su, Xi Li, Chao Wang, Chaoli Zhang and Meina Liu
The types of patients with gastric adenocarcinoma (GA) for whom postoperative radiotherapy can improve the disease-specific survival rate (DSS) remain controversial. This study aims to explore the ideal indica...
Authors: Ze-Ning Huang, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-long Zheng and Chang-Ming Huang
Many studies have reported the prevalence of chronic obstructive pulmonary disease (COPD) and its effects and prognosis in patients with lung cancer, but few have considered quality of life and survival of pat...
Authors: Young-Soo Yi, Woo Ho Ban and Kyeong-Yae Sohng
It has been reported that pathological complete response is an important surrogate marker for disease-free survival and overall survival in patients with triple-negative breast cancer. This study investigates ...
Authors: Paul Gass, Michael P. Lux, Claudia Rauh, Alexander Hein, Mayada R. Bani, Cornelia Fiessler, Arndt Hartmann, Lothar Häberle, Jutta Pretscher, Ramona Erber, David L. Wachter, Rüdiger Schulz-Wendtland, Matthias W. Beckmann, Peter A. Fasching and Marius Wunderle
The 2-week schedule of hypofractionated radiotherapy as a salvage treatment for hepatocellular carcinoma (HCC) has previously exhibited promising results; this study aimed to assess its long-term clinical outc...
Authors: Jongmoo Park, Jinhong Jung, Daegeun Kim, In-Hye Jung, Jin-hong Park, Jong Hoon Kim, Sang-wook Lee and Sang Min Yoon
Combined anthracycline-trastuzumab chemotherapy has been associated with LV dysfunction. We aimed to assess early changes in left ventricular (LV) and right ventricular (RV) mechanics associated with combined ...
Authors: Maria C. Arciniegas Calle, Nicole P. Sandhu, Hongmei Xia, Stephen S. Cha, Patricia A. Pellikka, Zi Ye, Joerg Herrmann and Hector R. Villarraga
Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dia...
Authors: Shankar Siva, Brent Chesson, Mathias Bressel, David Pryor, Braden Higgs, Hayley M. Reynolds, Nicholas Hardcastle, Rebecca Montgomery, Ben Vanneste, Vincent Khoo, Jeremy Ruben, Eddie Lau, Michael S. Hofman, Richard De Abreu Lourenco, Swetha Sridharan, Nicholas R. Brook…
The evolution of radiotherapy over recent decades has reintroduced the hypofractionation for many tumor sites with similar outcomes to those of conventional fractionated radiotherapy. The use of hypofractionat...
Authors: Alexandre Arthur Jacinto, Eronides Salustiano Batalha Filho, Luciano de Souza Viana, Pedro De Marchi, Renato de Castro Capuzzo, Ricardo Ribeiro Gama, Domingos Boldrini Junior, Carlos Roberto Santos, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Heloisa Pelisser Canton, Raiany Carvalho, Lucas Augusto Radicchi, Soren Bentzen, Eduardo Zubizarreta and Andre Lopes Carvalho
Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy of the skin characterized by high aggressiveness. Four main factors are implicated in its development: immunosuppression, ultraviolet radiation, ...
Authors: Daniele Lavacchi, Stefania Nobili, Marco Brugia, Agnese Paderi, Sara Fancelli, Enrico Caliman, Federica Vergoni and Enrico Mini
Nanoparticle albumin-bound (nab)-paclitaxel has better efficacy, safety profiles, and no need to use prophylactic steroids compared with solvent-based paclitaxel. We performed a single arm, phase II study to e...
Authors: Yannan Zhao, Fangfang Lv, She Chen, Zhonghua Wang, Jian Zhang, Sheng Zhang, Jun Cao, Leiping Wang, Enying Cao, Biyun Wang and Xichun Hu
MicroRNAs (miRNAs) are important regulators of cellular function and have been associated with both aging and cancer, but the impact of chemotherapy on age-related miRNAs has barely been studied.
Authors: Bruna Dalmasso, Sigrid Hatse, Barbara Brouwers, Annouschka Laenen, Lieze Berben, Cindy Kenis, Ann Smeets, Patrick Neven, Patrick Schöffski and Hans Wildiers
Compared with standard chemotherapy, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are more effective in patients with advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutat...
Authors: Naoto Aiko, Tsuneo Shimokawa, Kazuhito Miyazaki, Yuki Misumi, Yoko Agemi, Mari Ishii, Yukiko Nakamura, Takeharu Yamanaka and Hiroaki Okamoto
Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether his...
Authors: Marlies Antlanger, Tobias Dust, Thomas Reiter, Alexandra Böhm, Wolfgang W. Lamm, Max Gornicec, Ella Willenbacher, David Nachbaur, Roman Weger, Werner Rabitsch, Susanne Rasoul-Rockenschaub, Nina Worel, Daniel Lechner, Hildegard Greinix, Felix Keil, Heinz Gisslinger…
Ceritinib demonstrated a statistically significant effect on the progression-free survival versus chemotherapy in patients with advanced anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung ca...
Epithelioid hemangioendothelioma is an exceedingly rare sarcoma often occurring as an indolent angiocentric vascular tumor at various anatomic sites. Few reports have evaluated large case series of epithelioid...
Home parenteral nutrition (HPN) can improve survival, quality of life, nutritional and functional status in cancer patients. Bioelectrical impedance analysis (BIA) is a non-invasive, validated method to assess...
Authors: Paolo Cotogni, Taira Monge, Maurizio Fadda and Antonella De Francesco
Erlotinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Severe hepatotoxicity was observed in 4% to 31% of patients receiving erlotinib treatment prompting delay...
Authors: Min Kyoung Kim, Jeong Yee, Yoon Sook Cho, Hong Won Jang, Ji Min Han and Hye Sun Gwak
The combination of gemcitabine and docetaxel (GT) has been demonstrated to be effective against various types of solid tumors, including sarcoma. However, the regimen has not been confirmed in large, well-desi...
Although peripheral blood-based parameters (PBBPs) are reported as prognostic indicators in patients with breast cancers, their utility has not been studied in human epidermal growth factor receptor 2 (HER2)-p...
Adjuvant endocrine therapy undoubtedly prolongs the time to recurrence for patients with hormone-positive early breast cancer. Extended endocrine therapy to 10 years or longer has been expected to bring a grea...
Authors: Li Li, Bingmei Chang, Xiaoyue Jiang, Xueke Fan, Yingrui Li, Teng Li, Shanshan Wu, Jun Zhang, Seyed Kariminia and Qin Li
In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospec...
We report here a correlation analysis conducted along with a phase II trial assessing bevacizumab in combination with weekly paclitaxel.
Authors: Loïc Lebellec, François Bertucci, Emmanuelle Tresch-Bruneel, Isabelle Ray-Coquard, Axel Le Cesne, Emmanuelle Bompas, Jean-Yves Blay, Antoine Italiano, Olivier Mir, Thomas Ryckewaert, Yves Toiron, Luc Camoin, Anthony Goncalves, Nicolas Penel and Marie-Cécile Le Deley
The use of stereotactic body radiotherapy (SBRT) for early-stage primary non-small cell lung cancer (NSCLC) reported excellent local control rates. But the optimal SBRT dose for oligometastatic lung tumors (OL...
Authors: Xin Wang, Leonid Zamdborg, Hong Ye, Inga S. Grills and Di Yan
Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic d...
FIGHTDIGO study showed the feasibility and acceptability of handgrip strength (HGS) measure in routine in 201 consecutive patients with digestive cancer treated with ambulatory chemotherapy. The present study ...
Authors: Damien Botsen, Marie-Amélie Ordan, Coralie Barbe, Camille Mazza, Marine Perrier, Johanna Moreau, Mathilde Brasseur, Yohann Renard, Barbara Taillière, Florian Slimano, Eric Bertin and Olivier Bouché
Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting p...
Authors: András Folyovich, Viktória Varga, György Várallyay, Lajos Kozák, Mária Bakos, Erika Scheidl, Katalin Anna Béres-Molnár, Zita Kajdácsi and Dániel Bereczki
Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem.
Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is f...
Authors: Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller and Claudia Wickenhauser
The tyrosine kinase inhibitor pazopanib is used for treatment of sarcoma. Recent studies have suggested that the use of pazopanib may lead to the development of pneumothorax, an unexpected adverse effect in pa...
Authors: Bruce Sabath, Hasan A Muhammad, Amulya Balagani, David E Ost, Erik Vakil, Tahreem Ahmed, Macarena R Vial and Horiana B Grosu
Febrile neutropenia (FN) is a common occurrence during chemotherapy. Granulocyte colony-stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSF for patien...
Authors: Bernardo Leon Rapoport, Matti Aapro, Marianne Paesmans, Ronwyn van Eeden, Teresa Smit, Andriy Krendyukov and Jean Klastersky
The treatment recommendations for Low-grade Gliomas (LGG) underwent profound changes due to results from RTOG 9802 published in April 2016. This work aims to investigate whether the results from the trial were...
Authors: Christoph Straube, Kerstin A. Kessel, Friederike Schmidt-Graf, Sandro M. Krieg, Bernhard Meyer, Jens Gempt and Stephanie E. Combs
Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of end...
Authors: Ningning Li, Weixun Zhou, Lin Zhao and Jiaolin Zhou
Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imag...
Authors: Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner…
Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and valida...
Authors: A. L. McCarthy, N. M. Peel, K. M. Gillespie, R. Berry, E. Walpole, P. Yates and R. E. Hubbard
The aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadene...
Authors: Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang and Chang-Lin Zou
Basal cell adenocarcinomas (BCACs) arise from the minor salivary glands in the upper respiratory tract and are extremely rare. In this report, we present an unusual case of a 57-year-old male with BCAC that ar...
Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperat...
Authors: Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink…
To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50–60 Gy irradiation in breast cancer. However, these agents are also often used clinically f...
This was a prespecified secondary analysis of a randomized trial, which analyzed bone density following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT...
Authors: Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus and Harald Rief
Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumou...
Authors: Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis and Peter Grimison
High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited pub...
Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang and Luying Liu
Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23–31 months. There are several treatment options including chemotherapy and sometimes en...
Authors: Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli and Erika Viel
To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).
