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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 3 of 15

  1. Content type: Research article

    To evaluate the clinical outcome in patients with de novo metastatic nasopharyngeal carcinoma (NPC) treated or not treated with locoregional radiotherapy (LRRT) based on plasma Epstein–Barr virus (EBV) DNA lev...

    Authors: Xue-Song Sun, Li-Ting Liu, Sai-Lan Liu, Shan-Shan Guo, Yue-Feng Wen, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Jun Ma, Qiu-Yan Chen, Lin-Quan Tang and Hai-Qiang Mai

    Citation: BMC Cancer 2019 19:92

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  2. Content type: Research article

    The “EMERGE” study, aimed to capture real-life management patterns and outcomes in metastatic breast cancer (MBC) in Greece, also accounting for hormone (HR) and human epidermal growth factor receptor 2 (HER2)...

    Authors: Athanasios Kotsakis, Alexandros Ardavanis, Georgios Koumakis, Epameinondas Samantas, Amanta Psyrri and Christos Papadimitriou

    Citation: BMC Cancer 2019 19:88

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  3. Content type: Research article

    In this study, we observe the patterns initial palliative treatment for premenopausal patients with HR-positive/HER2-negative MBC and determine if nonadherence to clinical guidelines are associated with worse ...

    Authors: Hee Kyung Kim, Soo-Hyeon Lee, Yu Jin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu and Yeon Hee Park

    Citation: BMC Cancer 2019 19:84

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  4. Content type: Research article

    Neoadjuvant chemotherapy is effective in improving survival of resectable NSCLC. Based on findings in the adjuvant and metastatic setting, FDG positron emission tomography (PET) scans may offer early prognosti...

    Authors: Perrin E. Romine, Renato G. Martins, Keith D. Eaton, Douglas E. Wood, Fatemeh Behnia, Bernardo H. L. Goulart, Michael S. Mulligan, Sarah G. Wallace, Elizabeth Kell, Julie E. Bauman, Shilpen A. Patel and Hubert J. Vesselle

    Citation: BMC Cancer 2019 19:70

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  5. Content type: Study protocol

    The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablati...

    Authors: Houda Bahig, Francine Aubin, John Stagg, Olguta Gologan, Olivier Ballivy, Eric Bissada, Felix-Phuc Nguyen-Tan, Denis Soulières, Louis Guertin, Edith Filion, Apostolos Christopoulos, Louise Lambert, Mustapha Tehfe, Tareck Ayad, Danielle Charpentier, Rahima Jamal…

    Citation: BMC Cancer 2019 19:68

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  6. Content type: Research article

    Lanreotide depot/autogel antitumor activity in intestinal/pancreatic neuroendocrine tumors (NETs) was demonstrated in the phase-3 CLARINET study (NCT00353496), based on significantly prolonged progression-free...

    Authors: Clarisse Dromain, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin and Martyn E. Caplin

    Citation: BMC Cancer 2019 19:66

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  7. Content type: Research article

    For successful autologous stem cell transplantation, the collection of a sufficient number of hematopoietic stem cells after induction therapy is essential for transplant candidates with multiple myeloma (MM).

    Authors: Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Seung-Yeon Jung, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim and Je-Jung Lee

    Citation: BMC Cancer 2019 19:59

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  8. Content type: Research article

    Overall survival is the true endpoint for most randomized controlled trials (RCTs) of malignant tumors, whereas progression-free survival (PFS) is considered the most reliable surrogate endpoint for overall su...

    Authors: Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga and Hiroshi Tsumura

    Citation: BMC Cancer 2019 19:56

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  9. Content type: Research article

    Due to the significant heterogeneity of renal cell carcinoma (RCC), immune checkpoints may express differently between primary and metastatic tumor. We aimed to evaluate the differential expression of TIM-3 be...

    Authors: Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Kunpeng Shu, Jinge Zhao, Peng Zhao, Ni Chen, Jia Wang, Pengfei Shen and Hao Zeng

    Citation: BMC Cancer 2019 19:49

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  10. Content type: Research article

    In the recent phase III trial MPACT the combination of gemcitabine and nab-paclitaxel (Gem/NabP) showed increased overall survival compared to gemcitabine alone in the treatment of advanced pancreatic ductal a...

    Authors: Hakon Blomstrand, Ursula Scheibling, Charlotte Bratthäll, Henrik Green and Nils O. Elander

    Citation: BMC Cancer 2019 19:40

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  11. Content type: Research article

    Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS).

    Authors: Ursula M. Vogl, Haleh Andalibi, Alexander Klaus, Laurenz Vormittag, Wolfgang Schima, Bettina Heinrich, Alice Kafka, Thomas Winkler and Leopold Öhler

    Citation: BMC Cancer 2019 19:28

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  12. Content type: Research article

    Neuroendocrine cervical carcinoma (NECC) is a rare but aggressive form of cervical cancer representing less than 3% of all cervical cancer cases. The objective of this study is to evaluate the effects of the c...

    Authors: Xiaojing Zhang, Zunfu Lv and Hanmei Lou

    Citation: BMC Cancer 2019 19:22

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  13. Content type: Research article

    Radium-223, a targeted alpha therapy, is used to treat symptomatic patients with castration-resistant prostate cancer (CRPC) and bone metastases. Data for radium-223 in asymptomatic CRPC patients with bone met...

    Authors: Axel Heidenreich, Silke Gillessen, Daniel Heinrich, Daniel Keizman, Joe M. O’Sullivan, Joan Carles, Manfred Wirth, Kurt Miller, John Reeves, Monica Seger, Sten Nilsson and Fred Saad

    Citation: BMC Cancer 2019 19:12

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  14. Content type: Research article

    Gallbladder cancer (GBC) is likely to be diagnosed at progressive stages and shows a very poor prognosis. Combination therapy with gemcitabine and cisplatin (GEMCIS) has been widely used as first-line palliati...

    Authors: Min su You, Ji Kon Ryu, Young Hoon Choi, Jin Ho Choi, Gunn Huh, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim

    Citation: BMC Cancer 2019 19:10

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  15. Content type: Study protocol

    Even clearly resectable pancreatic cancer still has an unfavorable prognosis. Neoadjuvant or perioperative therapies might improve the prognosis of these patients. Thus, evaluation of perioperative chemotherap...

    Authors: Thomas J. Ettrich, Andreas W. Berger, Lukas Perkhofer, Severin Daum, Alexander König, Andreas Dickhut, Uwe Wittel, Kai Wille, Michael Geissler, Hana Algül, Eike Gallmeier, Jens Atzpodien, Marko Kornmann, Rainer Muche, Nicole Prasnikar, Andrea Tannapfel…

    Citation: BMC Cancer 2018 18:1298

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  16. Content type: Research article

    Despite increasing use, symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheter (PICC) is a common complication in nonmetastatic nasopharyngeal carcinoma (NPC) patients.

    Authors: Yu-Jing Liang, Lin-Quan Tang, Xue-Song Sun, Yu-Ying Fan, Jin-Jie Yan, Yu-Yun Du, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Sai-Lan Liu, Qing-Nan Tang, Xiao-Yun Li, Hai-Qiang Mai and Qiu-Yan Chen

    Citation: BMC Cancer 2018 18:1297

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  17. Content type: Case report

    Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been imp...

    Authors: Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick and Andrew J. Wagner

    Citation: BMC Cancer 2018 18:1296

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  18. Content type: Research article

    Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian can...

    Authors: William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir and Robert Ilaria Jr

    Citation: BMC Cancer 2018 18:1292

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  19. Content type: Research article

    Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based...

    Authors: Juan Zhao, Chunxiu Hu, Cheng Wang, Wei Yu, Yinglu Guo, Minghan Shi, Yongjie Shui and Qichun Wei

    Citation: BMC Cancer 2018 18:1290

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  20. Content type: Research article

    Palliative care, as a relatively young field within medicine, has increasingly used original research to validate and standardize its practice. In particular, palliative care has been incorporated into oncolog...

    Authors: Corbin Eule, Nizar Bhulani, Elizabeth Paulk, Ramona Rhodes and Muhammad Shaalan Beg

    Citation: BMC Cancer 2018 18:1281

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  21. Content type: Research article

    We wished to evaluate the efficacy and safety of liposomal paclitaxel and docetaxel for induction chemotherapy (IC) for nasopharyngeal carcinoma (NPC).

    Authors: Sai-Lan Liu, Xue-Song Sun, Xiao-Yun Li, Qiu-Yan Chen, Huan-Xin Lin, Yue-Feng Wen, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Lin-Quan Tang, Ling Guo…

    Citation: BMC Cancer 2018 18:1279

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  22. Content type: Research article

    The role of pretreatment Epstein-Barr virus DNA (pre-DNA) for individualized induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) still remains unknown. We aimed to address ...

    Authors: Jian Zhang, Hao Peng, Wen-Fei Li, Yuan Zhang, Li-Zhi Liu, Li Tian, Ai-Hua Lin, Ying Sun and Jun Ma

    Citation: BMC Cancer 2018 18:1276

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  23. Content type: Research article

    In the absence of head-to-head trials comparing axitinib with cabozantinib or everolimus, the aim of this study was to conduct an indirect comparison of their relative efficacy in patients with metastatic rena...

    Authors: Irina Proskorovsky, Agnes Benedict, Sylvie Negrier, Danielle Bargo, Rickard Sandin, Krishnan Ramaswamy, Jigar Desai, Joseph C. Cappelleri and James Larkin

    Citation: BMC Cancer 2018 18:1271

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  24. Content type: Research article

    The purpose of this study was to evaluate the clinical impact of oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX-4) chemotherapy in terms of the response rate, progression-free/overall survival (PFS/OS) an...

    Authors: Vincenza Conteduca, Giorgia Gurioli, Lorena Rossi, Emanuela Scarpi, Cristian Lolli, Giuseppe Schepisi, Alberto Farolfi, Delia De Lisi, Valentina Gallà, Salvatore Luca Burgio, Cecilia Menna, Andrea Amadori, Lorena Losi, Dino Amadori, Maria Paola Costi and Ugo De Giorgi

    Citation: BMC Cancer 2018 18:1267

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  25. Content type: Research article

    This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were a...

    Authors: Jung Sun Kim, Eun Joo Kang, Dae Sik Kim, Yoon Ji Choi, Suk Young Lee, Hong Jun Kim, Hee Yeon Seo and Jun Suk Kim

    Citation: BMC Cancer 2018 18:1260

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  26. Content type: Case report

    Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

    Authors: Zhenyu Lin, Junli Liu, Li Peng, Dejun Zhang, Ming Jin, Jing Wang, Jun Xue, Hongli Liu and Tao Zhang

    Citation: BMC Cancer 2018 18:1253

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  27. Content type: Research article

    Before the targeted therapies era, cytotoxic chemotherapy (CCT) was an option for advanced hepatocellular carcinoma (HCC), even with the lack of supporting evidence. Since the last decade, sorafenib has been e...

    Authors: Leonardo Gomes da Fonseca, Guilherme Nader Marta, Maria Ignez Freitas Melro Braghiroli, Aline Lopes Chagas, Flair Jose Carrilho, Paulo Marcelo Hoff and Jorge Sabbaga

    Citation: BMC Cancer 2018 18:1250

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  28. Content type: Research article

    Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to r...

    Authors: Anastasios Kyriazoglou, Michael Liontos, Dimitrios C Ziogas, Flora Zagouri, Kostantinos Koutsoukos, Giorgos Tsironis, Anna Tsiara, Maria Kaparelou, Roubini Zakopoulou, Nikolaos Thomakos, Dimitrios Haidopoulos, Irene Papaspyrou, Alexandros Rodolakis, Aristotelis Bamias and Meletios Athanasios Dimopoulos

    Citation: BMC Cancer 2018 18:1247

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  29. Content type: Research article

    Adaptive radiotherapy (ART) has potential benefits in patients with nasopharyngeal cancer (NPC). This retrospective study aimed to identify the factors favoring ART.

    Authors: Yu-Chang Hu, Kuo-Wang Tsai, Ching-Chih Lee, Nan-Jing Peng, Ju-Chun Chien, Hsin-Hui Tseng, Po-Chun Chen, Jin-Ching Lin and Wen-Shan Liu

    Citation: BMC Cancer 2018 18:1234

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  30. Content type: Research article

    We evaluated the safety and efficacy of induction chemotherapy with bevacizumab followed by maintenance chemotherapy with bevacizumab for advanced non-small cell lung cancer (NSCLC) in this multicenter phase I...

    Authors: Yasuhiro Tsutani, Yoshihiro Miyata, Takeshi Masuda, Kazunori Fujitaka, Mihoko Doi, Yoshikazu Awaya, Shoichi Kuyama, Soichi Kitaguchi, Kazuhiro Ueda, Noboru Hattori and Morihito Okada

    Citation: BMC Cancer 2018 18:1231

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  31. Content type: Case report

    Atypical BCR-ABL1 transcripts are detected in less than 5% of patients diagnosed with chronic myeloid leukaemia (CML), of which e19a2 is the most frequently observed, with breakpoints in the micro breakpoint clus...

    Authors: Nuno Cerveira, Rosa Branca Ferreira, Susana Bizarro, Cecília Correia, Lurdes Torres, Susana Lisboa, Joana Vieira, Rui Santos, Fernando Campilho, Carlos Pinho Vaz, Luís Leite, Manuel R. Teixeira and António Campos

    Citation: BMC Cancer 2018 18:1229

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  32. Content type: Research article

    Breast neoplasms are the most common cancer among women in Taiwan. Cognitive deficits are common complications of breast cancer survivors treated with chemotherapy. The most frequently observed disorders invol...

    Authors: Tsung-Yuan Li, Vincent Chin-Hung Chen, Dah-Cherng Yeh, Shu-Ling Huang, Cheng-Nan Chen, Jyh-Wen Chai, Clayton Chi-Chang Chen and Jun-Cheng Weng

    Citation: BMC Cancer 2018 18:1211

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  33. Content type: Research article

    Afatinib is an oral irreversible epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) indicated in first-line treatment of advanced EGFR-mutant (EGFRm+) non-small cell lung cancer (NSCLC). D...

    Authors: Wan-Ling Tan, Quan Sing Ng, Cindy Lim, Eng Huat Tan, Chee Keong Toh, Mei-Kim Ang, Ravindran Kanesvaran, Amit Jain, Daniel S. W. Tan and Darren Wan-Teck Lim

    Citation: BMC Cancer 2018 18:1198

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    The Correction to this article has been published in BMC Cancer 2018 18:1288

  34. Content type: Research article

    Treatment with nab-paclitaxel plus gemcitabine increases survival in patients with metastatic pancreatic cancer. However, the assessment of treatment efficacy and safety in non-selected patients in a real-life...

    Authors: Ana Fernández, Mercedes Salgado, Adelaida García, Elvira Buxò, Ruth Vera, Jorge Adeva, Paula Jiménez-Fonseca, Guillermo Quintero, Cristina Llorca, Mamen Cañabate, Luis Jesús López, Andrés Muñoz, Patricia Ramírez, Paula González, Carlos López, Margarita Reboredo…

    Citation: BMC Cancer 2018 18:1185

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  35. Content type: Research article

    Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radia...

    Authors: Anurag K. Singh, Mark Hennon, Sung Jun Ma, Todd L. Demmy, Anthony Picone, Elizabeth U. Dexter, Chumy Nwogu, Kristopher Attwood, Wei Tan, Gregory M. Hermann, Simon Fung-Kee-Fung, Harish K. Malhotra, Sai Yendamuri and Jorge A. Gomez-Suescun

    Citation: BMC Cancer 2018 18:1183

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  36. Content type: Research article

    Increasing evidence indicates that cetuximab (CET) combined with chemoradiotherapy may be effective for patients with esophageal cancer. However, the recent results are still contradictory and no consensus has...

    Authors: Ze-Hao Huang, Xiao-Wen Ma, Jing Zhang, Xiao Li, Na-Lin Lai and Sheng-Xiao Zhang

    Citation: BMC Cancer 2018 18:1170

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  37. Content type: Study protocol

    Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth fa...

    Authors: A. van Ommen-Nijhof, I. R. Konings, C. J. J. van Zeijl, C. A. Uyl-de Groot, V. van der Noort, A. Jager and G. S. Sonke

    Citation: BMC Cancer 2018 18:1146

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  38. Content type: Research article

    The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. The carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant treatment has been...

    Authors: Huabin Hu, Jin Huang, Ping Lan, Lei Wang, Meijin Huang, Jianping Wang and Yanhong Deng

    Citation: BMC Cancer 2018 18:1145

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  39. Content type: Case report

    Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramamm...

    Authors: Masamichi Yamaura, Takeshi Yamada, Rei Watanabe, Hitomi Kawai, Suguru Hirose, Hiroki Tajima, Masashi Sato, Yuichi Uchida, Daisuke Suganuma, Yoshiyuki Yamamoto, Toshikazu Moriwaki and Ichinosuke Hyodo

    Citation: BMC Cancer 2018 18:1142

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  40. Content type: Case report

    Multiple primary malignant tumors (MPMT) refers to the presence of two or more primary cancers of different organs in the same patient. MPMT is a sparse disease in the past, but there has been a gradual increa...

    Authors: Bo Jin, Simeng Zhang, Xin Chuang, Ping Yu, Ying Chen, Yuee Teng, Xiaofang Che, Yibo Fan, Chunlei Zheng, Xiaohan Li, Xueshan Qiu, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2018 18:1138

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  41. Content type: Case report

    Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies....

    Authors: Kohei Arimizu, Gen Hirano, Chinatsu Makiyama, Mioko Matsuo, Takakazu Sasaguri and Akitaka Makiyama

    Citation: BMC Cancer 2018 18:1134

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  42. Content type: Research article

    Trifluridine/tipiracil (TAS-102, Lonsurf®), a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiraci...

    Authors: Stefan Kasper, Jens Kisro, Martin Fuchs, Christian Müller, Armin Schulz-Abelius, Meinolf Karthaus, Mohammad-Reza Rafiyan and Alexander Stein

    Citation: BMC Cancer 2018 18:1124

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  43. Content type: Case report

    Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-...

    Authors: Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho and Chae-Yong Kim

    Citation: BMC Cancer 2018 18:1119

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  44. Content type: Research article

    To compare the efficacy of low dose (27 mg) Bacillus Calmette-Guérin (BCG) and a full dose (81 mg) BCG immunotherapy for patients with intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) afte...

    Authors: Zongren Wang, Han Xiao, Guangyan Wei, Ning Zhang, Mengchao Wei, Zebin Chen, Zhenwei Peng, Sui Peng, Shaopeng Qiu, Heping Li and Jianting Long

    Citation: BMC Cancer 2018 18:1108

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  45. Content type: Case report

    Chronic myeloid leukemia can be effectively treated with BCR-ABL1 tyrosine kinase inhibitors. However, BCR-ABL1 mutations can develop and cause secondary resistance to these inhibitors. For each of the availab...

    Authors: Radowan Elnair and Ahmed Galal

    Citation: BMC Cancer 2018 18:1097

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