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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 3 of 20

  1. This study aimed to evaluate the efficacy and the safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) pa...

    Authors: Yusuke Kitagawa, Hiroki Osumi, Eiji Shinozaki, Yumiko Ota, Izuma Nakayama, Takeshi Suzuki, Takeru Wakatsuki, Mariko Ogura, Akira Ooki, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin and Kensei Yamaguchi

    Citation: BMC Cancer 2020 20:358

    Content type: Research article

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  2. Tumor recurrence and metastasis occur at a high rate in patients with colon cancer. Identification of effective strategies for the treatment of colon cancer is critical. Recently, poly (lactic-co-glycolic acid...

    Authors: Pingping Wu, Qing Zhou, Huayun Zhu, Yan Zhuang and Jun Bao

    Citation: BMC Cancer 2020 20:354

    Content type: Research article

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  3. High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood st...

    Authors: Sandra Sauer, Petra Pavel, Anita Schmitt, Martin Cremer, Mark Kriegsmann, Thomas Bruckner, Karin Jordan, Patrick Wuchter, Carsten Müller-Tidow and Katharina Kriegsmann

    Citation: BMC Cancer 2020 20:353

    Content type: Research article

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  4. Planar-based measurements of lesions in metastatic melanoma have limitations in estimating tumor burden of a patient and in predicting response to treatment. Volumetric imaging might add predictive value to Re...

    Authors: Arwa Ali, Monica Dumbrava, Kylie Riddell, Nina Stewart, Robyn Ward, Ahmed K. Ibrahim and Melvin Chin

    Citation: BMC Cancer 2020 20:342

    Content type: Research article

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  5. Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes ...

    Authors: Sadayuki Kawai, Naoki Fukuda, Shun Yamamoto, Seiichiro Mitani, Katsuhiro Omae, Takeru Wakatsuki, Ken Kato, Shigenori Kadowaki, Daisuke Takahari, Narikazu Boku, Kei Muro and Nozomu Machida

    Citation: BMC Cancer 2020 20:338

    Content type: Research article

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  6. The standard treatment for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy (CRT) using 5-FU plus cisplatin. However, complete response (CR)...

    Authors: Hideaki Bando, Daisuke Kotani, Takahiro Tsushima, Hiroki Hara, Shigenori Kadowaki, Ken Kato, Keisho Chin, Kensei Yamaguchi, Shun-ichiro Kageyama, Hidehiro Hojo, Masaki Nakamura, Hidenobu Tachibana, Masashi Wakabayashi, Miki Fukutani, Yosuke Togashi, Nozomu Fuse…

    Citation: BMC Cancer 2020 20:336

    Content type: Study protocol

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  7. Unplanned hospitalization during cancer treatment is costly, can disrupt treatment, and affect patient quality of life. However, incidence and risks factors for hospitalization during lung cancer radiotherapy ...

    Authors: Sarah Z. Hazell, Nicholas Mai, Wei Fu, Chen Hu, Cole Friedes, Alex Negron, Khinh Ranh Voong, Josephine L. Feliciano, Peijin Han, Samantha Myers, Todd R. McNutt and Russell K. Hales

    Citation: BMC Cancer 2020 20:334

    Content type: Research article

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  8. The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who r...

    Authors: Kang Qin, Helei Hou, Yu Liang and Xiaochun Zhang

    Citation: BMC Cancer 2020 20:328

    Content type: Research article

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  9. In this retrospective study, we evaluated the biochemical recurrence rate, metastatic disease progression, and prostate cancer-specific and overall survival in patients curatively treated with external beam ra...

    Authors: Miikka Lehtonen, Lauri Heiskanen, Petri Reinikainen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: BMC Cancer 2020 20:324

    Content type: Research article

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  10. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficie...

    Authors: Tomoyuki Nakajima, Takeshi Uehara, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Maruyama and Hiroyoshi Ota

    Citation: BMC Cancer 2020 20:319

    Content type: Research article

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  11. Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of...

    Authors: Maria Paola Ciliberti, Roberta Carbonara, Antonietta Grillo, Anna Maria Leo, Ivan Lolli, Carmela Ostuni, Laura Troiani, Barbara Turi, Simona Vallarelli and Angela Sardaro

    Citation: BMC Cancer 2020 20:311

    Content type: Case report

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  12. Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic ...

    Authors: Sofie Olsson Hau, Alexandra Petersson, Björn Nodin, Emelie Karnevi, Karolina Boman, Caroline Williamsson, Jakob Eberhard, Karin Leandersson, David Gisselsson, Margareta Heby and Karin Jirström

    Citation: BMC Cancer 2020 20:308

    Content type: Study protocol

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  13. For novel cancer treatments, effectiveness in clinical practice is not always aligned with clinical efficacy results. As such it is important to understand a treatment’s real-world effectiveness. We examined r...

    Authors: Wei Fang Dai, Jaclyn M. Beca, Ruth Croxford, Wanrudee Isaranawatchai, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Timothy P. Hanna and Kelvin K.W. Chan

    Citation: BMC Cancer 2020 20:304

    Content type: Research article

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  14. To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy ...

    Authors: Dongqing Wang, Shui Yu, Limin Zhai, Jin Xu and Baosheng Li

    Citation: BMC Cancer 2020 20:283

    Content type: Research article

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  15. There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite the sizable percentage of these patients in clinical practice. This stu...

    Authors: Nan Bi, Lipin Liu, Jun Liang, Shixiu Wu, Ming Chen, Changxing Lv, Lujun Zhao, Anhui Shi, Wei Jiang, Yaping Xu, Zongmei Zhou, Jingbo Wang, Wenqing Wang, Dongfu Chen, Zhouguang Hui, Jima Lv…

    Citation: BMC Cancer 2020 20:278

    Content type: Research article

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  16. To evaluate the value of new therapies for non-small cell lung cancer (NSCLC), it is necessary to understand overall survival (OS) rates associated with previous standard therapies and how these rates have evo...

    Authors: Ryan N. Hansen, Yiduo Zhang, Brian Seal, Kellie Ryan, Candice Yong, Annie Darilay and Scott D. Ramsey

    Citation: BMC Cancer 2020 20:276

    Content type: Research article

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  17. Combination of gemcitabine and nab-paclitaxel has superior clinical efficacy than gemcitabine alone. Nevertheless, health-related quality of life. (QoL) associated with this combination therapy when administer...

    Authors: Suayib Yalcin, Faysal Dane, Berna Oksuzoglu, Nuriye Yildirim Ozdemir, Abdurrahman Isikdogan, Metin Ozkan, Guzin Gonullu Demirag, Hasan Senol Coskun, Bulent Karabulut, Turkkan Evrensel, Mehmet Ali Ustaoglu, Feyyaz Ozdemir, Hande Turna, Tugba Yavuzsen, Faruk Aykan, Alper Sevinc…

    Citation: BMC Cancer 2020 20:259

    Content type: Research article

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  18. The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.

    Authors: Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li…

    Citation: BMC Cancer 2020 20:255

    Content type: Research article

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  19. Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this d...

    Authors: Fangbin Zhou, Donge Tang, Yong Xu, Huiyan He, Yan Wu, Liewen Lin, Jun Dong, Wenyong Tan and Yong Dai

    Citation: BMC Cancer 2020 20:242

    Content type: Research article

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  20. Prophylactic cranial irradiation (PCI) is a current standard of care after confirmed response to radical chemoradiotherapy for limited disease small cell lung cancer (LD-SCLC). This standard is mostly based on...

    Authors: Sergiusz Nawrocki and Anna Sugajska

    Citation: BMC Cancer 2020 20:231

    Content type: Study protocol

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  21. As the number of PET/CT scanners increases and FDG PET/CT becomes a common imaging modality for oncology, the demands for automated detection systems on artificial intelligence (AI) to prevent human oversight ...

    Authors: Keisuke Kawauchi, Sho Furuya, Kenji Hirata, Chietsugu Katoh, Osamu Manabe, Kentaro Kobayashi, Shiro Watanabe and Tohru Shiga

    Citation: BMC Cancer 2020 20:227

    Content type: Research article

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  22. Even though treatment modalities such as adjuvant systemic radio-chemotherapy and neoadjuvant chemotherapy (NAC) have individually have improved overall survival (OS) and progression-free survival (PFS) rates ...

    Authors: Maneesh Kumarsing Beeharry, Zhen-Tian Ni, Zhong Yin Yang, Ya Nan Zheng, Run Hua Feng, Wen-Tao Liu, Chao Yan, Xue Xin Yao, Chen Li, Min Yan and Zheng-Gang Zhu

    Citation: BMC Cancer 2020 20:224

    Content type: Study protocol

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  23. To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases ...

    Authors: Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu and Qiang Wei

    Citation: BMC Cancer 2020 20:220

    Content type: Research article

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  24. Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and progno...

    Authors: Takehiro Tozuka, Satoru Kitazono, Hiroaki Sakamoto, Hiroshi Yoshida, Yoshiaki Amino, Shinya Uematsu, Takahiro Yoshizawa, Tsukasa Hasegawa, Ken Uchibori, Noriko Yanagitani, Atsushi Horiike, Takeshi Horai, Masahiro Seike, Akihiko Gemma and Makoto Nishio

    Citation: BMC Cancer 2020 20:207

    Content type: Research article

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  25. The current study aimed to evaluate the outcomes of patients with unresectable non-metastatic locally advanced pancreatic adenocarcinoma (LAPA) who did not benefit from resection considering the treatment stra...

    Authors: Jonathan Garnier, Jacques Ewald, Ugo Marchese, Marine Gilabert, Simon Launay, Laurence Moureau-Zabotto, Flora Poizat, Marc Giovannini, Jean-Robert Delpero and Olivier Turrini

    Citation: BMC Cancer 2020 20:203

    Content type: Research article

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  26. Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (...

    Authors: Justina Ucheojor Onwuka, Akinkunmi Paul Okekunle, Olaniyi Matthew Olutola, Onoja Matthew Akpa and Rennan Feng

    Citation: BMC Cancer 2020 20:200

    Content type: Research article

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  27. Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ip...

    Authors: Nicholas F. Brown, Stasya M. Ng, Claire Brooks, Tim Coutts, Jane Holmes, Corran Roberts, Leena Elhussein, Peter Hoskin, Tim Maughan, Sarah Blagden and Paul Mulholland

    Citation: BMC Cancer 2020 20:198

    Content type: Study protocol

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  28. To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for l...

    Authors: Katherine Meng, Jeremy Tey, Francis Cho Hao Ho, Hira Asim and Timothy Cheo

    Citation: BMC Cancer 2020 20:193

    Content type: Research article

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  29. This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients.

    Authors: Ping Liu, Lihong Lin, Yanxiang Kong, Zhifeng Huo, Lin Zhu, Xiaonong Bin, Jinghe Lang and Chunlin Chen

    Citation: BMC Cancer 2020 20:189

    Content type: Research article

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  30. Serum miRNA was once found as potential disease survival index,thus we investigated the role of miRNA in predicting prognosis in loco-regionally advanced NPC patients treated with CCRT.

    Authors: Zhimin Zhang, Jiangbiao Huang, Ge Wang, Feng Jin, Jijun Zheng, He Xiao, Lin Lei, Jia Luo and Chuan Chen

    Citation: BMC Cancer 2020 20:183

    Content type: Research article

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  31. Aspiration pneumonia is one of the most important side effects of chemoradiotherapy (CRT) and bio-radiotherapy (BRT) in patients with head and neck cancer (HNC). Aspiration pneumonia can lead to cancer-related...

    Authors: Hiromichi Shirasu, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Keita Mori and Hirofumi Yasui

    Citation: BMC Cancer 2020 20:182

    Content type: Research article

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  32. It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in ...

    Authors: Zhengwu Sun, Xiaoyan Lan, Shizhao Xu, Shen Li and Yalin Xi

    Citation: BMC Cancer 2020 20:180

    Content type: Research article

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  33. Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune syst...

    Authors: Anastasios Dimou, Gregory Barron, Daniel T. Merrick, Jason Kolfenbach and Robert C. Doebele

    Citation: BMC Cancer 2020 20:177

    Content type: Case report

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  34. Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting.

    Authors: Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn and Seung Soo Sheen

    Citation: BMC Cancer 2020 20:167

    Content type: Research article

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  35. High rates of venous thromboembolic events (VTEs), mainly in advanced disease, are reported for patients with cancer of the upper gastrointestinal tract (stomach, pancreas) and for treatment with cisplatin.

    Authors: Martin Fehr, Hanne Hawle, Stefanie Hayoz, Peter Thuss-Patience, Sabina Schacher, Jorge Riera Knorrenschild, Donat Dürr, Wolfram T. Knoefel, Holger Rumpold, Michael Bitzer, Martin Zweifel, Panagiotis Samaras, Ulrich Mey, Marc Küng, Ralph Winterhalder, Wolfgang Eisterer…

    Citation: BMC Cancer 2020 20:166

    Content type: Research article

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  36. Cancer-related fatigue (CRF) is one of the most prevalent complications experienced by cancer patients during and after the process of treatment. Despite conducting a lot of studies, there is no approved thera...

    Authors: Ebrahim Salehifar, Saeid Azimi, Ghasem Janbabai, Ehsan Zaboli, Narjes Hendouei, Fatemeh Saghafi and Samaneh Borhani

    Citation: BMC Cancer 2020 20:158

    Content type: Research article

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  37. Rash is one of the most common severe adverse events associated with use of vemurafenib for the treatment of melanoma, either as monotherapy or in combination with cobimetinib. The study aimed to identify pre-...

    Authors: Ashley M. Hopkins, Akash D. Rathod, Andrew Rowland, Ganessan Kichenadasse and Michael J. Sorich

    Citation: BMC Cancer 2020 20:157

    Content type: Research article

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  38. A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the ...

    Authors: Yuta Adachi, Naohiro Yanagimura, Chiaki Suzuki, Sakiko Ootani, Azusa Tanimoto, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi and Seiji Yano

    Citation: BMC Cancer 2020 20:156

    Content type: Case report

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  39. Gemcitabine/erlotinib treatment offers limited benefit in unselected patients with pancreatic ductal adenocarcinoma (PDAC). Development of skin rash has been associated with favorable outcomes in patients trea...

    Authors: C. Benedikt Westphalen, Tobias Kukiolka, Benjamin Garlipp, Lars Hahn, Martin Fuchs, Peter Malfertheiner, Marcel Reiser, Fabian Kütting, Volker Heinemann, Andreas Beringer and Dirk T. Waldschmidt

    Citation: BMC Cancer 2020 20:155

    Content type: Research article

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  40. There is a discrepancy about the metastatic rate of internal mammary lymph nodes (IMNs) between clinical and pathologic findings. We aimed to investigate the metastatic rate of IMNs and to provide recommendati...

    Authors: Li Li, Hongyan Zhang, Linwei Wang, Conghua Xie, Yunfeng Zhou and Yahua Zhong

    Citation: BMC Cancer 2020 20:153

    Content type: Research article

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  41. Brain metastases often occur in cancer evolution. They are not only responsible for death but also for disorders affecting the quality of life and the cognitive functions.

    Authors: Paul Lesueur, William Kao, Alexandra Leconte, Julien Geffrelot, Justine Lequesne, Joëlle Lacroix, Pierre-Emmanuel Brachet, Ioana Hrab, Philippe Royer, Bénédicte Clarisse and Dinu Stefan

    Citation: BMC Cancer 2020 20:147

    Content type: Study protocol

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  42. Information on the optimal salvage regimen for recurrent esophageal cancer is scarce. We aimed to assess the patterns of locoregional failure, and evaluate the therapeutic efficacy of salvage therapy along wit...

    Authors: Wenjie Ni, Jinsong Yang, Wei Deng, Zefen Xiao, Zongmei Zhou, Hongxing Zhang, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Xiaozhen Wang, Xin Wang, Tao Zhang, Nan Bi, Lei Deng and Wenqing Wang

    Citation: BMC Cancer 2020 20:144

    Content type: Research article

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  43. Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in...

    Authors: Frederikke Petrine Fliedner, Trine Bjørnbo Engel, Henrik H. El-Ali, Anders Elias Hansen and Andreas Kjaer

    Citation: BMC Cancer 2020 20:134

    Content type: Research article

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  44. The importance of ACF is not fully explained, however, their number may be a good predictor of synchronous and metachronic adenoma or other polyps whose removal reduces the risk of CRC. Due to the epidemiologi...

    Authors: Marek Kowalczyk, Marcin Orłowski, Łukasz Klepacki, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Dorota Kaczerska, Wiesław Pesta, Ewa Zieliński and Piotr Siermontowski

    Citation: BMC Cancer 2020 20:133

    Content type: Research article

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  45. Colorectal cancer (CRC) is the third most prevalent cancer in China but few large-scale studies were conducted to understand CRC patients. The current study is aimed to gain a real-world perspectives of CRC pa...

    Authors: Ruihua Xu, Wei Wang, Bo Zhu, Xiaoyan Lin, Dong Ma, Lingjun Zhu, Qingchuan Zhao, Yongzhan Nie, Xiaohong Cai, Qi Li, Weijia Fang, Hongyan Li, Ning Wang, Yun Chen, Cike Peng, Honghao Fang…

    Citation: BMC Cancer 2020 20:131

    Content type: Research article

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  46. Preoperative chemoradiotherapy (CRT) followed by surgery is the most common approach for patients with resectable esophageal cancer. Nevertheless, considerable numbers of esophageal-cancer patients undergo sur...

    Authors: Wenjie Ni, Shufei Yu, Wencheng Zhang, Zefen Xiao, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Kelin Sun, Xiangyang Liu, Dekang Fang, Jian Li…

    Citation: BMC Cancer 2020 20:130

    Content type: Study protocol

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  47. The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD...

    Authors: Inju Cho, Hansang Lee, Sang Eun Yoon, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim and Seok Jin Kim

    Citation: BMC Cancer 2020 20:120

    Content type: Research article

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