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BMC Cancer

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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

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  1. Content type: Research article

    We aimed to explore the clinical benefit of adjuvant chemotherapy (AC) with fluoropyrimidine in patients with ypT0-3N0 rectal cancer after preoperative chemoradiation therapy (CRT) followed by total mesorectal...

    Authors: Chang Gon Kim, Joong Bae Ahn, Sang Joon Shin, Seung Hoon Beom, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Eun Ah Choe, Woong Sub Koom, Hyuk Hur, Byung Soh Min, Nam Kyu Kim, Hoguen Kim, Chan Kim, Inkyung Jung and Minkyu Jung

    Citation: BMC Cancer 2017 17:615

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  2. Content type: Research article

    Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is opt...

    Authors: Sanghyuk Song, Hong-Gyun Wu, Chang Geol Lee, Ki Chang Keum, Mi Sun Kim, Yong Chan Ahn, Dongryul Oh, Hyo Jung Park, Sang-Wook Lee, Geumju Park, Sung Ho Moon, Kwan Ho Cho, Yeon-Sil Kim, Yongkyun Won, Young-Taek Oh, Won-Taek Kim…

    Citation: BMC Cancer 2017 17:598

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  3. Content type: Research article

    Using propensity score matching method (PSM) to evaluate the feasibility and clinical outcomes of simultaneous modulated accelerated radiation therapy (SMART) using helical tomotherapy (HT) in patients with na...

    Authors: Lei Du, Xin-Xin Zhang, Lin-Chun Feng, Bao-Lin Qu, Jing Chen, Jun Yang, Hai-Xia Liu, Shou-Ping Xu, Chuan-Bin Xie and Lin Ma

    Citation: BMC Cancer 2017 17:582

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  4. Content type: Research article

    The effect of endocrine therapy with tamoxifen (TMX) on weight gain has been reported in the literature, but the outcomes are still controversial. Moreover, previous treatment options, such as chemotherapy (CT...

    Authors: Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Fernanda Silva Mazzutti, Marcelo de Almeida Maia, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva and Yara Cristina de Paiva Maia

    Citation: BMC Cancer 2017 17:578

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  5. Content type: Research article

    We conducted a multicenter randomized study of adjuvant S-1 administration schedules for surgically treated pathological stage IB-IIIA non-small cell lung cancer patients.

    Authors: Yoshinobu Hata, Takaharu Kiribayashi, Kazuma Kishi, Makoto Nagashima, Takefumi Nakayama, Shingo Ikeda, Mitsutaka Kadokura, Yuichi Ozeki, Hajime Otsuka, Yoshitaka Murakami, Keigo Takagi and Akira Iyoda

    Citation: BMC Cancer 2017 17:581

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  6. Content type: Research article

    Elderly patient with advanced cancer is one of the most vulnerable populations. Skeletal muscle depletion during chemotherapy may have substantial impact on their physical function. However, there is little in...

    Authors: Tateaki Naito, Taro Okayama, Takashi Aoyama, Takuya Ohashi, Yoshiyuki Masuda, Madoka Kimura, Hitomi Shiozaki, Haruyasu Murakami, Hirotsugu Kenmotsu, Tetsuhiko Taira, Akira Ono, Kazushige Wakuda, Hisao Imai, Takuya Oyakawa, Takeshi Ishii, Shota Omori…

    Citation: BMC Cancer 2017 17:571

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  7. Content type: Study protocol

    The squamous cell carcinoma of the anus (SCCA) is a rare disease, but its incidence is markedly increasing. About 15% of patients are diagnosed at metastatic stage, and more than 20% with a localized disease t...

    Authors: Stefano Kim, Marine Jary, Thierry André, Véronique Vendrely, Bruno Buecher, Eric François, François-Clément Bidard, Sarah Dumont, Emmanuelle Samalin, Didier Peiffert, Simon Pernot, Nabil Baba-Hamed, Farid El Hajbi, Olivier Bouché, Jérôme Desrame, Aurélie Parzy…

    Citation: BMC Cancer 2017 17:574

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  8. Content type: Research article

    To compare the PSA value at the last follow-up of patients who underwent prostate low-dose rate brachytherapy (LDR-BT) with that of patients who underwent intensity-modulated radiation therapy (IMRT).

    Authors: Nobumichi Tanaka, Isao Asakawa, Yasushi Nakai, Makito Miyake, Satoshi Anai, Tomomi Fujii, Masatoshi Hasegawa, Noboru Konishi and Kiyohide Fujimoto

    Citation: BMC Cancer 2017 17:573

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  9. Content type: Research article

    This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetu...

    Authors: Yang Li, Qiu-Yan Chen, Lin-Quan Tang, Li-Ting Liu, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Ming-Yuan Chen, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Shen Zeng, Jin-Xin Bei, Jian-Yong Shao, Ying Sun, Jing Tan…

    Citation: BMC Cancer 2017 17:567

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  10. Content type: Research article

    The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the r...

    Authors: Thamires Monteiro do Carmo, Bianca Sakamoto Ribeiro Paiva, Cleyton Zanardo de Oliveira, Maria Salete de Angelis Nascimento and Carlos Eduardo Paiva

    Citation: BMC Cancer 2017 17:564

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  11. Content type: Research article

    Various studies have reported that the neutrophil-to-lymphocyte ratio in the serum (sNLR) may serve as a cost-effective and useful prognostic factor in patients with various cancer types. However, no study has...

    Authors: Yong Seok Lee, Hae-Seong Nam, Jun Hyeok Lim, Jung Soo Kim, Yeonsook Moon, Jae Hwa Cho, Jeong-Seon Ryu, Seung Min Kwak and Hong Lyeol Lee

    Citation: BMC Cancer 2017 17:557

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  12. Content type: Study protocol

    Metastatic colorectal cancer (mCRC) is a disease of older age, but there is a relative lack of knowledge about effects of chemotherapy in older patients as they are under-represented in clinical trials. Little...

    Authors: Stine Braendegaard Winther, Pia Österlund, Åke Berglund, Bengt Glimelius, Camilla Qvortrup, Halfdan Sorbye and Per Pfeiffer

    Citation: BMC Cancer 2017 17:548

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  13. Content type: Study protocol

    New generation hormone-therapies (NGHT) targeting the androgen signalling pathway are nowadays proposed to elderly patients with metastatic castration-resistant prostate cancer (CRPCa). The impact of these tre...

    Authors: Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi…

    Citation: BMC Cancer 2017 17:549

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  14. Content type: Research article

    Vascular endothelial growth factor (VEGF) directed therapies are being used in a large number of advanced tumors. Metastatic renal cell carcinoma (mRCC) is highly dependent on the VEGF pathway; VEGF receptor (...

    Authors: Sylvie Négrier, David Pérol, Rastislav Bahleda, Antoine Hollebecque, Etienne Chatelut, Helen Boyle, Philippe Cassier, Séverine Metzger, Ellen Blanc, Jean-Charles Soria and Bernard Escudier

    Citation: BMC Cancer 2017 17:547

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  15. Content type: Case report

    Bleomycin-induced lung injury, a major complication of chemotherapy for germ cell tumors, occasionally fails to respond to the standard treatment with corticosteroids and develops into severe respiratory insuf...

    Authors: Koji Sakamoto, Satoru Ito, Naozumi Hashimoto and Yoshinori Hasegawa

    Citation: BMC Cancer 2017 17:526

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  16. Content type: Research article

    The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients ...

    Authors: Weiwei Zhao, Peng Wang, Huixun Jia, Menglei Chen, Xiaoli Gu, Minghui Liu, Zhe Zhang, Wenwu Cheng and Zhenyu Wu

    Citation: BMC Cancer 2017 17:514

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  17. Content type: Research article

    Concurrent chemoradiotherapy (CCRT) is the standard treatment for local advanced cervical cancer. However, for elderly patients, studies are limited and the outcomes are controversial. We retrospectively analy...

    Authors: Weiping Wang, Xiaorong Hou, Junfang Yan, Jie Shen, Xin Lian, Shuai Sun, Zhikai Liu, Qingyu Meng, Dunhuang Wang, Mei Zhao, Jie Qiu, Ke Hu and Fuquan Zhang

    Citation: BMC Cancer 2017 17:510

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  18. Content type: Study protocol

    The optimal duration of firstline chemotherapy in metastatic esophagogastric cancer is unknown. In most clinical trials therapy was given until tumour progression or limiting toxicity. Maintenance concepts aim...

    Authors: Georg-Martin Haag, Gertraud Stocker, Julia Quidde, Dirk Jaeger and Florian Lordick

    Citation: BMC Cancer 2017 17:509

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