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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 20 of 20

  1. Thymic carcinoma is a rare cancer with minimal evidence of a survival benefit following chemotherapy. An oral fluoropyrimidine of S-1, however, is the recommended active cytotoxic chemotherapy agent for refrac...

    Authors: Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura and Tsunekazu Hishima

    Citation: BMC Cancer 2016 16:156

    Content type: Research article

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    The Erratum to this article has been published in BMC Cancer 2016 16:272

  2. Combined treatment with cisplatin and gemcitabine (CisGem) is the standard of care for patients with advanced biliary tract cancer (ABC). Selumetinib (AZD6244, ARRY-142886) potently and selectively inhibits ME...

    Authors: John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan and Juan W. Valle

    Citation: BMC Cancer 2016 16:153

    Content type: Research article

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    The Erratum to this article has been published in BMC Cancer 2016 16:369

  3. According to the literature and our experience, the most common sites of non-small cell lung cancer (NSCLC) metastases include the brain, bone, liver, adrenal glands, contralateral lung and distant lymph nodes...

    Authors: Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang…

    Citation: BMC Cancer 2016 16:149

    Content type: Research article

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  4. Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in...

    Authors: Victor H. F. Lee, Dennis K. C. Leung, Tim-Shing Choy, Ka-On Lam, Pui-Mei Lam, To-Wai Leung and Dora L. W. Kwong

    Citation: BMC Cancer 2016 16:147

    Content type: Research article

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  5. We compared the outcome of patients who received non-image-guided intensity-modulated radiotherapy (IMRT) with those who received helical tomotherapy (HT), a daily image-guided radiotherapy (IGRT), after surge...

    Authors: Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Yu-Chuen Huang, Li-Jen Liao, Wu-Chia Lo, Yu-Chin Lin, Le-Jung Wu and Hui-Ju Tien

    Citation: BMC Cancer 2016 16:139

    Content type: Research article

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  6. The impact of such recommendations after their implementation of guidelines has not usually been evaluated. Herein, we assessed the impact and compliance with the Spanish Oncology Genitourinary Group (SOGUG) G...

    Authors: Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M. Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A. Climent-Duran, Martín Lázaro-Quintela, Aranzazu González del Alba, María José Méndez-Vidal…

    Citation: BMC Cancer 2016 16:135

    Content type: Research article

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  7. Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of ind...

    Authors: M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, M. van de Sande, C. G. Gerestein, H. W. Nijman and R. F. P. M. Kruitwagen

    Citation: BMC Cancer 2016 16:132

    Content type: Study protocol

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  8. Pancreatic panniculitis is a rare condition, which has only been described in relation with pancreatic diseases up to now. It is characterized by necrotizing subcutaneous inflammation and is thought to be trig...

    Authors: Sebastian Zundler, Ramona Erber, Abbas Agaimy, Arndt Hartmann, Franklin Kiesewetter, Deike Strobel, Markus F. Neurath and Dane Wildner

    Citation: BMC Cancer 2016 16:130

    Content type: Case report

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  9. Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether...

    Authors: Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers and Thomas Eade

    Citation: BMC Cancer 2016 16:124

    Content type: Research article

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  10. Health-related quality of life (HRQoL) is recognized as a component endpoint for cancer therapy approvals. The aim of this review was to evaluate the methodology of HRQoL analysis and reporting in phase III cl...

    Authors: Frédéric Fiteni, Amélie Anota, Virginie Westeel and Franck Bonnetain

    Citation: BMC Cancer 2016 16:122

    Content type: Research article

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  11. Vinorelbine constitutes effective chemotherapy for metastatic breast cancer (MBC) and acts synergistically with trastuzumab in HER-2/neu positive disease. The present study was set out to evaluate the efficacy an...

    Authors: Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz and Christoph Zielinski

    Citation: BMC Cancer 2016 16:121

    Content type: Research article

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  12. Small-cell lung cancer (SCLC) is known to express antigens of both the neural crest and epithelium, and to secrete polypeptide hormones and enzymes. Anecdotal reports correlate lung cancer with marked hyperamy...

    Authors: Andrea Casadei Gardini, Marita Mariotti, Alessandro Lucchesi, Sara Pini, Martina Valgiusti, Sara Bravaccini, Angelo Del Monte, Marco Angelo Burgio, Giorgia Marisi, Dino Amadori and Giovanni Luca Frassineti

    Citation: BMC Cancer 2016 16:118

    Content type: Case report

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  13. The accuracy of 18F-fluorodeoxygluocose positron emission tomography/computed tomography (PET/CT) in predicting immediate failure after radical chemoradiotherapy (CRT) for HNSCC is poorly characterized at present...

    Authors: Ryul Kim, Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Jin Ho Kim, Jin Chul Paeng, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung and Dae Seog Heo

    Citation: BMC Cancer 2016 16:116

    Content type: Research article

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  14. Brainstem dose limitations influence radiation dose reaching to tumor in the patients with locally-advanced nasopharyngeal cancer (NPC).

    Authors: Yuxiang He, Ying Wang, Lin Shen, Yajie Zhao, Pengfei Cao, Mingjun Lei, Dengming Chen, Tubao Yang, Liangfang Shen and Shousong Cao

    Citation: BMC Cancer 2016 16:114

    Content type: Research article

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  15. The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies....

    Authors: Takashi Kawahara, Yumiko Yokomizo, Yusuke Ito, Hiroki Ito, Hitoshi Ishiguro, Jun-ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Hiroshi Miyamoto, Masahiro Yao and Hiroji Uemura

    Citation: BMC Cancer 2016 16:111

    Content type: Research article

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  16. Although the efficacy of bevacizumab has been established in patients with metastatic colorectal cancer (mCRC), population-based studies are needed to gain insight into the actual implementation of bevacizumab...

    Authors: L. G. E. M. Razenberg, Y. R. B. M. van Gestel, I. H. J. T. de Hingh, O. J. L. Loosveld, G. Vreugdenhil, L. V. Beerepoot, G. J. Creemers and V. E. P. P. Lemmens

    Citation: BMC Cancer 2016 16:110

    Content type: Research article

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  17. The overall purpose of this study is to provide proof of concept for introducing the anthracycline epirubicin as an effective, biomarker-guided treatment for metastatic colorectal cancer (mCRC) patients who ar...

    Authors: Line S. Tarpgaard, Camilla Qvortrup, Sune B. Nygård, Signe L. Nielsen, Diana R. Andersen, Niels Frank Jensen, Jan Stenvang, Sönke Detlefsen, Nils Brünner and Per Pfeiffer

    Citation: BMC Cancer 2016 16:91

    Content type: Study protocol

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  18. Gastrointestinal stromal tumors (GISTs) are characterized by mutations of KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) or PDGFRA (platelet-derived growth factor receptor α) that may be effi...

    Authors: Francesca Maria Rizzo, Raffaele Palmirotta, Andrea Marzullo, Nicoletta Resta, Mauro Cives, Marco Tucci and Franco Silvestris

    Citation: BMC Cancer 2016 16:87

    Content type: Research article

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  19. The purpose of this observational study was to evaluate feasibility, efficacy results and toxicity observations of capecitabine in routine first line treatment of patients with metastatic colorectal cancer, wi...

    Authors: Alexander Stein, Julia Quidde, Jan Klaus Schröder, Thomas Göhler, Barbara Tschechne, Annette-Rosel Valdix, Heinz-Gert Höffkes, Silke Schirrmacher-Memmel, Tim Wohlfarth, Axel Hinke, Andreas Engelen and Dirk Arnold

    Citation: BMC Cancer 2016 16:82

    Content type: Research article

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  20. To date, standardized strategies for the treatment of recurrent glioma are lacking. Chemotherapy with the alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitroso-urea) is a therapeutic option even though its ...

    Authors: Christine Jungk, Despina Chatziaslanidou, Rezvan Ahmadi, David Capper, Justo Lorenzo Bermejo, Janina Exner, Andreas von Deimling, Christel Herold-Mende and Andreas Unterberg

    Citation: BMC Cancer 2016 16:81

    Content type: Research article

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  21. Cachexia is a multi-factorial, systemic syndrome that especially affects patients with cancer of the gastrointestinal tract, and leads to reduced treatment response, survival and quality of life. The most impo...

    Authors: Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess and Marc E. Martignoni

    Citation: BMC Cancer 2016 16:75

    Content type: Review

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  22. The ToGA study showed that trastuzumab plus chemotherapy prolonged median survival in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer. Among chemotherapy options,...

    Authors: Jifang Gong, Tianshu Liu, Qingxia Fan, Li Bai, Feng Bi, Shukui Qin, Jinwan Wang, Nong Xu, Ying Cheng, Yuxian Bai, Wei Liu, Liwei Wang and Lin Shen

    Citation: BMC Cancer 2016 16:68

    Content type: Research article

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  23. Various molecular-targeting therapies have become available for the treatment of advanced renal cell carcinoma (RCC). Accurate prognostication is desirable for choosing the appropriate treatment for individual...

    Authors: Noboru Nakaigawa, Keiichi Kondo, Ukihide Tateishi, Ryogo Minamimoto, Tomohiro Kaneta, Kazuhiro Namura, Daiki Ueno, Kazuki Kobayashi, Takeshi Kishida, Ichiro Ikeda, Hisashi Hasumi, Kazuhide Makiyama, Yoshinobu Kubota, Tomio Inoue and Masahiro Yao

    Citation: BMC Cancer 2016 16:67

    Content type: Research article

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  24. Rebiopsy is highly recommended to identify the mechanism of acquired resistance to EGFR-TKIs in advanced lung cancer. Recent advances in multiplex genotyping based on circulating tumor DNA (ctDNA) provide a st...

    Authors: Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou and Jianxing He

    Citation: BMC Cancer 2016 16:62

    Content type: Case report

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  25. To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (...

    Authors: Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima and Rocco Damiano

    Citation: BMC Cancer 2016 16:59

    Content type: Research article

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  26. The efficacy and safety of lenalidomide plus low-dose dexamethasone (Rd) in Chinese patients with relapsed/refractory multiple myeloma (RRMM) was demonstrated in a phase 2, multicenter trial (MM-021). MM-024 w...

    Authors: Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei and Jian Hou

    Citation: BMC Cancer 2016 16:46

    Content type: Research article

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  27. With increasing numbers of patients with unresectable locoregionally advanced (LA) head and neck squamous cell carcinoma (HNSCC) receiving cetuximab/radiotherapy (RT), several guidelines on the early detection...

    Authors: Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy and Xia He

    Citation: BMC Cancer 2016 16:42

    Content type: Correspondence

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  28. The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully expl...

    Authors: Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama

    Citation: BMC Cancer 2016 16:41

    Content type: Research article

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  29. Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection...

    Authors: Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven and Hans Morreau

    Citation: BMC Cancer 2016 16:31

    Content type: Case report

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  30. Trabectedin is an antineoplastic agent used for patients with soft tissue sarcoma (STS) who fail standard-of-care treatment. Real-world data of its performance is scarce. This study evaluates the safety and ef...

    Authors: Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson and Martin E. Blackstein

    Citation: BMC Cancer 2016 16:30

    Content type: Research article

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  31. Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal t...

    Authors: Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga…

    Citation: BMC Cancer 2016 16:22

    Content type: Research article

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  32. The current study was conducted to examine the activity of a docetaxel/oxaliplatin (DocOx) combination as second line treatment for advanced pancreatic ductal adenocarcinoma (Trial registration: NCT00690300. R...

    Authors: Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle and Thomas Seufferlein

    Citation: BMC Cancer 2016 16:21

    Content type: Research article

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  33. Cetuximab, in combination with platinum chemotherapy plus 5-fluoruracil (5-FU), is approved for the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). Cetuximab ...

    Authors: Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin and Douglas Adkins

    Citation: BMC Cancer 2016 16:19

    Content type: Research article

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  34. Signs and symptoms of a rapidly enlarging breast mass are not only important for all clinicians to recognize and assess, but also are not uncommon occurrences. We describe a similar but unique case that develo...

    Authors: Vivek Verma, Sanjay Muttineni, Rajesh R. Kulkarni, Edibaldo Silva-Lopez, William W. West and Robert B. Thompson

    Citation: BMC Cancer 2015 15:1008

    Content type: Case report

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  35. Hypereosinophilia, defined by an absolute eosinophil count of more than 1500/mm3, is rarely observed in patients treated for cancer, and rarely imputable to anti-cancer agents. Drug-induced hypereosinophilia u...

    Authors: Diaddin Hamdan, Christophe Leboeuf, Cathy Pereira, Nathalie Jourdan, Laurence Verneuil, Guilhem Bousquet and Anne Janin

    Citation: BMC Cancer 2015 15:993

    Content type: Case report

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  36. Surgery and stereotactic ablative radiotherapy (SABR) are both curative treatment options for patients with a stage I non-small cell lung cancer (NSCLC). Consequently, there is growing interest in studying the...

    Authors: Wendy Hopmans, Olga C. Damman, Suresh Senan, Koen J. Hartemink, Egbert F. Smit and Danielle R. M. Timmermans

    Citation: BMC Cancer 2015 15:959

    Content type: Research article

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  37. Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa...

    Authors: Sebastian Hinz, Christian Röder, Jürgen Tepel, Alexander Hendricks, Clemens Schafmayer, Thomas Becker and Holger Kalthoff

    Citation: BMC Cancer 2015 15:953

    Content type: Research article

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  38. Current knowledge indicate that epirubicin administration in late pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin pregnancy complicated by breast cancer in which epirubicin administrat...

    Authors: Marialuisa Framarino-dei-Malatesta, Giuseppina Perrone, Antonella Giancotti, Flavia Ventriglia, Martina Derme, Isabella Iannini, Valentina Tibaldi, Paola Galoppi, Paolo Sammartino, Gianluca Cascialli and Roberto Brunelli

    Citation: BMC Cancer 2015 15:951

    Content type: Case report

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  39. To compare the efficacy and toxicity of irinotecan-based chemotherapy (IBC) and non-irinotecan-based chemotherapy (NIBC) as first-line treatment for stage IIIB/IV non-small cell lung cancer (NSCLC).

    Authors: Xue-Qin Yang, Chong-Yi Li, Ming-Fang Xu, Hong Zhao and Dong Wang

    Citation: BMC Cancer 2015 15:949

    Content type: Research article

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  40. Median overall survival (OS) of patients with melanoma brain metastases (MBM) is usually 6 months or less. There are rare reports of patients with treated MBM who survived for years. These outlier cases repres...

    Authors: Sarah Weiss, Farbod Darvishian, Jyothi Tadepalli, Richard Shapiro, John Golfinos, Anna Pavlick, David Polsky, Tomas Kirchhoff and Iman Osman

    Citation: BMC Cancer 2015 15:926

    Content type: Case report

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  41. The objective of this study is to explore the off-label use of targeted therapies (TTs) for patients with osteosarcoma registered within the French Sarcoma Group – Bone Tumor Study Group (GSF-GETO) national re...

    Authors: Mathilde Penel-Page, Isabelle Ray-Coquard, Julie Larcade, Magali Girodet, Laure Bouclier, Muriel Rogasik, Nadège Corradini, Natacha Entz-Werle, Laurence Brugieres, Julien Domont, Cyril Lervat, Sophie Piperno-Neumann, Helène Pacquement, Jacques-Olivier Bay, Jean-Claude Gentet, Antoine Thyss…

    Citation: BMC Cancer 2015 15:854

    Content type: Research article

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  42. Durability of androgen-deprivation therapy (ADT) for prostate cancer (PC) is limited. Additional selective estrogen receptor modulators (SERMs) may prolong the durability of ADT, because androgen and estrogen ...

    Authors: Tetsuya Fujimura, Satoru Takahashi, Haruki Kume, Tomohiko Urano, Kenichi Takayama, Yuta Yamada, Motofumi Suzuki, Hiroshi Fukuhara, Tohru Nakagawa, Satoshi Inoue and Yukio Homma

    Citation: BMC Cancer 2015 15:836

    Content type: Research article

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  43. Locally recurrent non-small cell lung cancer (NSCLC) poses a great challenge to physicians. This study aimed to explore the efficacy and safety of the combination of brachytherapy and docetaxel and cisplatin f...

    Authors: Xiaojuan Yu, Jin Li, Xiaoming Zhong and Jingdong He

    Citation: BMC Cancer 2015 15:656

    Content type: Research article

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