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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 14 of 15

  1. Content type: Study protocol

    Despite novel therapeutic agents, most multiple myeloma (MM) patients eventually relapse. Two large phase III trials have shown significantly improved response rates (RR) of lenalidomide/dexamethasone compared...

    Authors: Marc-Andrea Baertsch, Jana Schlenzka, Elias K. Mai, Maximilian Merz, Jens Hillengaß, Marc S. Raab, Dirk Hose, Patrick Wuchter, Anthony D. Ho, Anna Jauch, Thomas Hielscher, Christina Kunz, Steffen Luntz, Stefan Klein, Ingo G. H. Schmidt-Wolf, Martin Goerner…

    Citation: BMC Cancer 2016 16:290

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  2. Content type: Research article

    Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radi...

    Authors: Xiao-Cang Ren, Quan-Yu Wang, Rui Zhang, Xue-Ji Chen, Na Wang, Yue-E Liu, Jie Zong, Zhi-Jun Guo, Dong-Ying Wang and Qiang Lin

    Citation: BMC Cancer 2016 16:288

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  3. Content type: Research article

    Ependymal tumors in adults are rare, accounting for less than 4 % of primary tumors of the central nervous system in this age group. The low prevalence of intracranial ependymoma in adults limits the ability t...

    Authors: Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger and Michael Weller

    Citation: BMC Cancer 2016 16:287

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  4. Content type: Research article

    Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to ...

    Authors: Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi and Juan Antonio Madrid

    Citation: BMC Cancer 2016 16:285

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  5. Content type: Study protocol

    Primary central nervous system lymphoma (PCNSL) is a highly aggressive Non-Hodgkin lymphoma (NHL) with rising incidence over the past 30 years in immunocompetent patients. Although outcomes have improved, PCNS...

    Authors: Elisabeth Schorb, Juergen Finke, Andrés J. M. Ferreri, Gabriele Ihorst, Kristina Mikesch, Benjamin Kasenda, Kristina Fritsch, Heidi Fricker, Elvira Burger, Olga Grishina, Elke Valk, Emanuele Zucca and Gerald Illerhaus

    Citation: BMC Cancer 2016 16:282

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  6. Content type: Research article

    Few new compounds are available for relapsed osteosarcoma. We retrospectively evaluated the activity of gemcitabine (G) plus docetaxel (D) in patients with relapsed high-grade osteosarcoma and high-grade spind...

    Authors: E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci and S. Ferrari

    Citation: BMC Cancer 2016 16:280

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  7. Content type: Study protocol

    Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant pleural mesothelioma, but all the studies published thus far were based upon a variety of empirical and possibly suboptimal schedules,...

    Authors: Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, Bruno Lacarelle, Nicolas André and Fabrice Barlesi

    Citation: BMC Cancer 2016 16:278

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  8. Content type: Research article

    Rituximab (R) in combination with DHAP is a widely accepted salvage regimen for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). A common adverse effect of this protocol is renal tox...

    Authors: K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho and M. Witzens-Harig

    Citation: BMC Cancer 2016 16:267

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  9. Content type: Research article

    Endostatin inhibits the pro-angiogenic action of basic fibroblast growth factor and vascular endothelial growth factor in different human cancers. This study assessed the efficacy of endostatin combined with c...

    Authors: Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu and Sheng-Lin Ma

    Citation: BMC Cancer 2016 16:266

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  10. Content type: Research article

    Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate...

    Authors: Yan Sun, Ying Cheng, Xuezhi Hao, Jie Wang, Chengping Hu, Baohui Han, Xiaoqing Liu, Li Zhang, Huiping Wan, Zhongjun Xia, Yunpeng Liu, Wei Li, Mei Hou, Helong Zhang, Qingyu Xiu, Yunzhong Zhu…

    Citation: BMC Cancer 2016 16:265

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  11. Content type: Research article

    Brain metastases (BM) from colorectal cancer (CRC) are a rare event. However, the implications for affected patients are severe, and the incidence has been reported to be increasing. For clinicians, knowledge ...

    Authors: Troels Dreier Christensen, Karen-Lise Garm Spindler, Jesper Andreas Palshof and Dorte Lisbet Nielsen

    Citation: BMC Cancer 2016 16:260

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  12. Content type: Research article

    Axitinib is a potent inhibitor of the vascular endothelial growth factor (VEGF) receptor family with clinical activity in patients with metastatic renal cell carcinoma (mRCC). Given this biochemical potency, t...

    Authors: Namita Chittoria, Housam Haddad, Paul Elson, Nizar M. Tannir, Laura S. Wood, Robert Dreicer, Jorge A. Garcia, Brian I. Rini and Eric Jonasch

    Citation: BMC Cancer 2016 16:254

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  13. Content type: Research article

    The prognostic value of rectal invasion is still unclear in stage IVA cervical cancer. The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated wit...

    Authors: Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Shintaro Shiba, Tadashi Kamada and Takashi Nakano

    Citation: BMC Cancer 2016 16:244

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  14. Content type: Case report

    The use of neoadjuvant radiation therapy and chemotherapy in the treatment of locally advanced rectal adenocarcinoma has been shown to reduce disease recurrence when combined with surgery and adjuvant chemothe...

    Authors: Matthew M. Florczynski, Michael S. Sanatani, Lauren Mai, Barbara Fisher, Dwight E. Moulin, Jeffrey Cao, Alexander V. Louie, Janet E. Pope and Eric Leung

    Citation: BMC Cancer 2016 16:243

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  15. Content type: Research article

    The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and ...

    Authors: Gongjun Tan, Qianxu Liu, Xiaowei Tang, Ting Kang, Yuejin Li, Jinping Lu, Xiaoming Zhao and Faqing Tang

    Citation: BMC Cancer 2016 16:241

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  16. Content type: Research article

    Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro C...

    Authors: Neo M. Tapela, Tharcisse Mpunga, Bethany Hedt-Gauthier, Molly Moore, Egide Mpanumusingo, Mary Jue Xu, Ignace Nzayisenga, Vedaste Hategekimana, Denis Gilbert Umuhizi, Lydia E. Pace, Jean Bosco Bigirimana, JingJing Wang, Caitlin Driscoll, Frank R. Uwizeye, Peter C. Drobac, Gedeon Ngoga…

    Citation: BMC Cancer 2016 16:237

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  17. Content type: Research article

    In the analysis of survival data for cancer patients, the problem of competing risks is often ignored. Competing risks have been recognized as a special case of time-to-event analysis. The conventional techniq...

    Authors: Yen-Hou Chang, Wai-Hou Li, Yi Chang, Chia-Wen Peng, Ching-Hsuan Cheng, Wei-Pin Chang and Chi-Mu Chuang

    Citation: BMC Cancer 2016 16:235

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  18. Content type: Case report

    Systemic chemotherapy combined with steroids used as prophylactic antiemetics have been reported to induce immunosuppression. Further, herpes simplex virus-1 (HSV-1) infection has been reported to occur in pat...

    Authors: Masaaki Saito, Hirokazu Kiyozaki, Tamotu Obitsu, Hirofumi Imoto, Yusuke Taniyama, Osamu Takata and Toshiki Rikiyama

    Citation: BMC Cancer 2016 16:233

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  19. Content type: Case report

    Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant tumor susceptibility syndrome, and the disease-related gene has been identified as fumarate hydratase (fumarase, FH). HLRCC-asso...

    Authors: Takao Kamai, Hideyuki Abe, Kyoko Arai, Satoshi Murakami, Setsu Sakamoto, Yasushi Kaji and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2016 16:232

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  20. Content type: Research article

    To compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation therapy (RT) in patients with spinal bone metastases. Second...

    Authors: Harald Rief, Georg Omlor, Michael Akbar, Thomas Bruckner, Stefan Rieken, Robert Förster, Ingmar Schlampp, Thomas Welzel, Tilman Bostel, Heinz Jürgen Roth and Jürgen Debus

    Citation: BMC Cancer 2016 16:231

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  21. Content type: Research article

    Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosi...

    Authors: Pierre Kunz, Heiner Sähr, Burkhard Lehner, Christian Fischer, Elisabeth Seebach and Jörg Fellenberg

    Citation: BMC Cancer 2016 16:223

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  22. Content type: Research article

    Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Recen...

    Authors: Ko Sato, Satoshi Watanabe, Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa and Ichiei Narita

    Citation: BMC Cancer 2016 16:222

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  23. Content type: Research article

    To retrospectively assess the efficacy and safety of Vinflunine (VFL) under routine conditions and identify overall survival (OS) prognostic factors.

    Authors: Jacques Médioni, Mario Di Palma, Aline Guillot, Dominique Spaeth and Christine Théodore

    Citation: BMC Cancer 2016 16:217

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  24. Content type: Research article

    The role of remission status in limited disease (LD) small-cell lung cancer (SCLC) patients treated with definitive chemoradiotherapy (CRT) remains to be finally clarified.

    Authors: Farkhad Manapov, Maximilian Niyazi, Sabine Gerum, Olarn Roengvoraphoj, Chukwuka Eze, Minglun Li, Guido Hildebrandt, Rainer Fietkau, Gunther Klautke and Claus Belka

    Citation: BMC Cancer 2016 16:216

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  25. Content type: Research article

    Significant progress in treatment of metastatic castration resistant prostate cancer (mCRPC) has been made. Biomarkers to tailor therapy are scarce. To facilitate decision-making we evaluated dynamic changes o...

    Authors: Phillip Mikah, Laura-Maria Krabbe, Okyaz Eminaga, Edwin Herrmann, Philipp Papavassilis, Reemt Hinkelammert, Axel Semjonow, Andres-Jan Schrader and Martin Boegemann

    Citation: BMC Cancer 2016 16:214

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  26. Content type: Research article

    It remains a matter of debate whether colorectal cancer resection in an emergency setting negatively impacts on survival. Our objective was therefore to assess the impact of urgent versus elective operation on...

    Authors: Benjamin Weixler, Rene Warschkow, Michaela Ramser, Raoul Droeser, Urs von Holzen, Daniel Oertli and Christoph Kettelhack

    Citation: BMC Cancer 2016 16:208

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  27. Content type: Research article

    Advanced non-small cell lung cancer (NSCLC) patients often develop thromboembolic events, including cerebral infarction (CI). However, the relationship between advanced NSCLC and CI has not been thoroughly inv...

    Authors: Motoyasu Kato, Takehito Shukuya, Keita Mori, Ryota Kanemaru, Yuichiro Honma, Yuta Nanjo, Keiko Muraki, Rina Shibayama, Ryo Koyama, Naoko Shimada, Fumiyuki Takahashi and Kazuhisa Takahashi

    Citation: BMC Cancer 2016 16:203

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  28. Content type: Research article

    The efficacy of combined modality therapy is evaluated for patients with extensive-stage (ES) small cell lung cancer (SCLC). This study evaluated prognostic factors affecting the risk of thoracic progression i...

    Authors: Tomoya Fukui, Michiko Itabashi, Mikiko Ishihara, Yasuhiro Hiyoshi, Masashi Kasajima, Satoshi Igawa, Jiichiro Sasaki and Noriyuki Masuda

    Citation: BMC Cancer 2016 16:197

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  29. Content type: Study protocol

    Radiation therapy is the method of choice for subjects with inoperable salivary gland malignancies. I-125 brachytherapy, delivering a high radiation dose to a tumor but sparing surrounding normal tissues, is s...

    Authors: Shu-Ming Liu, Hai-Bo Wang, Yan Sun, Yan Shi, Jie Zhang, Ming-Wei Huang, Lei Zheng, Xiao-Ming Lv, Bao-Min Zheng, Kathleen H. Reilly, Xiao-Yan Yan, Ping Ji, Yang-feng Wu and Jian-Guo Zhang

    Citation: BMC Cancer 2016 16:193

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  30. Content type: Research article

    The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is ...

    Authors: Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki…

    Citation: BMC Cancer 2016 16:192

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  31. Content type: Research article

    There is no reliable biomarker for predicting the prognosis of patients who undergo radical cystectomy for bladder cancer. Recent studies have shown that the neutrophil-to-lymphocyte ratio (NLR) could function...

    Authors: Takashi Kawahara, Kazuhiro Furuya, Manami Nakamura, Kentaro Sakamaki, Kimito Osaka, Hiroki Ito, Yusuke Ito, Koji Izumi, Shinji Ohtake, Yasuhide Miyoshi, Kazuhide Makiyama, Noboru Nakaigawa, Takeharu Yamanaka, Hiroshi Miyamoto, Masahiro Yao and Hiroji Uemura

    Citation: BMC Cancer 2016 16:185

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  32. Content type: Study protocol

    Stereotactic ablative body radiotherapy (SABR) is emerging as a non-invasive method for precision irradiation of lung tumours. However, the ideal dose/fractionation schedule is not yet known. The primary purpo...

    Authors: Shankar Siva, Tomas Kron, Mathias Bressel, Marion Haas, Tao Mai, Shalini Vinod, Giuseppe Sasso, Wenchang Wong, Hien Le, Thomas Eade, Nicholas Hardcastle, Brent Chesson, Daniel Pham, Morten Høyer, Rebecca Montgomery and David Ball

    Citation: BMC Cancer 2016 16:183

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  33. Content type: Research article

    Whether androgen deprivation therapy (ADT) leads to stroke morbidity is still unclear because of inconsistent evidence. We performed a systematic review and meta-analysis to evaluate if ADT used in men with pr...

    Authors: Fanzheng Meng, Shimiao Zhu, Jinsheng Zhao, Larissa Vados, Lei Wang, Yusheng Zhao, Dan Zhao and Yuanjie Niu

    Citation: BMC Cancer 2016 16:180

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  34. Content type: Research article

    The study is to evaluate the patterns of failure, toxicities and long-term outcomes of aggressive treatment using 18F-FDG PET/CT-guided chemoradiation plannings for advanced cervical cancer with extensive nodal e...

    Authors: Yih-Lin Chung, Cheng-Fang Horng, Pei-Ing Lee and Fong-Lin Chen

    Citation: BMC Cancer 2016 16:179

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  35. Content type: Research article

    The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. The present study was therefore undertaken to investigate the association between critical weight loss and long-term su...

    Authors: Qi Zeng, Lu-Jun Shen, Xiang Guo, Xin-Ming Guo, Chao-Nan Qian and Pei-Hong Wu

    Citation: BMC Cancer 2016 16:169

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  36. Content type: Research article

    APF530 provides controlled, sustained-release granisetron for preventing acute (0–24 h) and delayed (24–120 h) chemotherapy-induced nausea and vomiting (CINV). In a phase III trial, APF530 was noninferior to p...

    Authors: Ralph Boccia, Erin O’Boyle and William Cooper

    Citation: BMC Cancer 2016 16:166

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  37. Content type: Research article

    Thymic carcinoma is a rare cancer with minimal evidence of a survival benefit following chemotherapy. An oral fluoropyrimidine of S-1, however, is the recommended active cytotoxic chemotherapy agent for refrac...

    Authors: Yusuke Okuma, Yukio Hosomi, Shingo Miyamoto, Masahiko Shibuya, Tatsuru Okamura and Tsunekazu Hishima

    Citation: BMC Cancer 2016 16:156

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    The Erratum to this article has been published in BMC Cancer 2016 16:272

  38. Content type: Research article

    Combined treatment with cisplatin and gemcitabine (CisGem) is the standard of care for patients with advanced biliary tract cancer (ABC). Selumetinib (AZD6244, ARRY-142886) potently and selectively inhibits ME...

    Authors: John Bridgewater, Andre Lopes, Sandra Beare, Marian Duggan, Dymphna Lee, Maravic Ricamara, Delyth McEntee, Ajithkumar Sukumaran, Harpreet Wasan and Juan W. Valle

    Citation: BMC Cancer 2016 16:153

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    The Erratum to this article has been published in BMC Cancer 2016 16:369

  39. Content type: Research article

    According to the literature and our experience, the most common sites of non-small cell lung cancer (NSCLC) metastases include the brain, bone, liver, adrenal glands, contralateral lung and distant lymph nodes...

    Authors: Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang…

    Citation: BMC Cancer 2016 16:149

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  40. Content type: Research article

    Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in...

    Authors: Victor H. F. Lee, Dennis K. C. Leung, Tim-Shing Choy, Ka-On Lam, Pui-Mei Lam, To-Wai Leung and Dora L. W. Kwong

    Citation: BMC Cancer 2016 16:147

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  41. Content type: Research article

    We compared the outcome of patients who received non-image-guided intensity-modulated radiotherapy (IMRT) with those who received helical tomotherapy (HT), a daily image-guided radiotherapy (IGRT), after surge...

    Authors: Chen-Hsi Hsieh, Pei-Wei Shueng, Li-Ying Wang, Yu-Chuen Huang, Li-Jen Liao, Wu-Chia Lo, Yu-Chin Lin, Le-Jung Wu and Hui-Ju Tien

    Citation: BMC Cancer 2016 16:139

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  42. Content type: Research article

    The impact of such recommendations after their implementation of guidelines has not usually been evaluated. Herein, we assessed the impact and compliance with the Spanish Oncology Genitourinary Group (SOGUG) G...

    Authors: Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M. Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A. Climent-Duran, Martín Lázaro-Quintela, Aranzazu González del Alba, María José Méndez-Vidal…

    Citation: BMC Cancer 2016 16:135

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  43. Content type: Study protocol

    Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of ind...

    Authors: M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, M. van de Sande, C. G. Gerestein, H. W. Nijman and R. F. P. M. Kruitwagen

    Citation: BMC Cancer 2016 16:132

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  44. Content type: Case report

    Pancreatic panniculitis is a rare condition, which has only been described in relation with pancreatic diseases up to now. It is characterized by necrotizing subcutaneous inflammation and is thought to be trig...

    Authors: Sebastian Zundler, Ramona Erber, Abbas Agaimy, Arndt Hartmann, Franklin Kiesewetter, Deike Strobel, Markus F. Neurath and Dane Wildner

    Citation: BMC Cancer 2016 16:130

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  45. Content type: Research article

    Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether...

    Authors: Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers and Thomas Eade

    Citation: BMC Cancer 2016 16:124

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  46. Content type: Research article

    Health-related quality of life (HRQoL) is recognized as a component endpoint for cancer therapy approvals. The aim of this review was to evaluate the methodology of HRQoL analysis and reporting in phase III cl...

    Authors: Frédéric Fiteni, Amélie Anota, Virginie Westeel and Franck Bonnetain

    Citation: BMC Cancer 2016 16:122

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  47. Content type: Research article

    Vinorelbine constitutes effective chemotherapy for metastatic breast cancer (MBC) and acts synergistically with trastuzumab in HER-2/neu positive disease. The present study was set out to evaluate the efficacy an...

    Authors: Christiane Thallinger, Istvan Lang, Cvetka Grasic Kuhar, Rupert Bartsch, Christian F. Singer, Lubos Petruzelka, Bohuslav Melichar, Regina Knittelfelder, Thomas Brodowicz and Christoph Zielinski

    Citation: BMC Cancer 2016 16:121

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  48. Content type: Case report

    Small-cell lung cancer (SCLC) is known to express antigens of both the neural crest and epithelium, and to secrete polypeptide hormones and enzymes. Anecdotal reports correlate lung cancer with marked hyperamy...

    Authors: Andrea Casadei Gardini, Marita Mariotti, Alessandro Lucchesi, Sara Pini, Martina Valgiusti, Sara Bravaccini, Angelo Del Monte, Marco Angelo Burgio, Giorgia Marisi, Dino Amadori and Giovanni Luca Frassineti

    Citation: BMC Cancer 2016 16:118

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