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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 13 of 15

  1. Content type: Research article

    Previous population-based studies have demonstrated an association between metformin use and improved survival among diabetic patients with cancer. We sought to analyze the effects of diabetes and its treatmen...

    Authors: Oscar Arrieta, Edgar Varela-Santoyo, Enrique Soto-Perez-de-Celis, Roberto Sánchez-Reyes, Martha De la Torre-Vallejo, Saé Muñiz-Hernández and Andrés F. Cardona

    Citation: BMC Cancer 2016 16:633

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  2. Content type: Research article

    The preferred chemotherapy method for gastric cancer continues to be matter of debate. We performed a meta-analysis to comparing prognosis and safety between perioperative chemotherapy and adjuvant chemotherap...

    Authors: Jun-hua Zhao, Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Bin Ma, Yu-chong Yang and Zhen-ning Wang

    Citation: BMC Cancer 2016 16:631

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  3. Content type: Research article

    Anthracyclines, as the most effective therapy, are the cornerstone of advanced stage sarcoma treatment. However, anthracyclines can also contribute to myocardial dysfunction and congestive heart failure, ultim...

    Authors: Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt and Daniel Pink

    Citation: BMC Cancer 2016 16:619

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  4. Content type: Research article

    Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we ...

    Authors: Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee

    Citation: BMC Cancer 2016 16:613

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  5. Content type: Case report

    Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor...

    Authors: Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen and Yu-Ping Li

    Citation: BMC Cancer 2016 16:593

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  6. Content type: Case report

    Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a com...

    Authors: Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak and Jun Suk Kim

    Citation: BMC Cancer 2016 16:588

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  7. Content type: Research article

    To identify predictors of prolonged or shortened progression-free survival (PFS) and overall survival (OS) among patients with metastatic renal cell carcinoma (mRCC) who received first-line targeted therapies.

    Authors: Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee and Jinsoo Chung

    Citation: BMC Cancer 2016 16:577

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  8. Content type: Case report

    HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated wi...

    Authors: Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux and Béatrice Weber

    Citation: BMC Cancer 2016 16:573

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  9. Content type: Debate

    Primary invasive Extramammary Paget’s vulvar disease is a rare tumor that is challenging to control. Wide surgical excision represents the standard treatment approach for Primary invasive Extramammary Paget’s ...

    Authors: Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias and George Kyrgias

    Citation: BMC Cancer 2016 16:563

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  10. Content type: Research article

    Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) has been studed in several cancers including cervical cancer. This study was designed to investigate the association of DW-MRI parameters with baseline ...

    Authors: Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda and Mitchell Kamrava

    Citation: BMC Cancer 2016 16:556

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  11. Content type: Case report

    Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disse...

    Authors: Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt and Gilles Dolivet

    Citation: BMC Cancer 2016 16:552

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  12. Content type: Case report

    Sorafenib is the standard first-line therapy for hepatocellular carcinoma (HCC) and probably ectopic hepatocellular carcinoma (EHCC) as well. No report involves a side effect of delayed high fever of sorafenib...

    Authors: Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang and Jianguo Sun

    Citation: BMC Cancer 2016 16:543

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  13. Content type: Research article

    The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than in Western countries, are well...

    Authors: Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li…

    Citation: BMC Cancer 2016 16:537

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  14. Content type: Research article

    The increasingly complex programs of contemporary cancer therapy emphasize the need for biological indicators of both therapeutic response and adverse effects. One example is combined-modality treatment aimed ...

    Authors: Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark and Anne Hansen Ree

    Citation: BMC Cancer 2016 16:536

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  15. Content type: Research article

    Adequate prediction of survival plays an important role in treatment decisions for patients with spinal bone metastases (SBM). Several prognostic factors are already used in daily clinical practice, but factor...

    Authors: Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief and German Bone Research Group

    Citation: BMC Cancer 2016 16:528

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  16. Content type: Research article

    Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6–8 cycles of NAC has become the stand...

    Authors: Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park and Dong-Young Noh

    Citation: BMC Cancer 2016 16:515

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  17. Content type: Research article

    In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients.

    Authors: Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer and Jens Ricke

    Citation: BMC Cancer 2016 16:509

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  18. Content type: Study protocol

    Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality tr...

    Authors: Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt and J. Rüdiger Siewert

    Citation: BMC Cancer 2016 16:503

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  19. Content type: Research article

    To report the results of combined chemoradiation (CCRT) with cisplatin versus carboplatin in locally advanced cervical carcinoma.

    Authors: Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae and Imjai Chitapanarux

    Citation: BMC Cancer 2016 16:501

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  20. Content type: Research article

    Maintenance treatment (MTx) in responders following first-line treatment has been investigated and practiced for many cancers. Modeling and simulation may support interpretation of interim data and development...

    Authors: Kelong Han, Laurent Claret, Alan Sandler, Asha Das, Jin Jin and Rene Bruno

    Citation: BMC Cancer 2016 16:473

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  21. Content type: Research article

    Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the eff...

    Authors: James M. Cleary, Harvey J. Mamon, Jackie Szymonifka, Raphael Bueno, Noah Choi, Dean M. Donahue, Panos M. Fidias, Henning A. Gaissert, Michael T. Jaklitsch, Matthew H. Kulke, Thomas P. Lynch, Steven J. Mentzer, Jeffrey A. Meyerhardt, Richard S. Swanson, John Wain, Charles S. Fuchs…

    Citation: BMC Cancer 2016 16:468

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  22. Content type: Research article

    TAS-102 (trifluridine and tipiracil hydrochloride; a novel combination oral nucleoside anti-tumor agent) has recently received regulatory approval for patients with refractory metastatic colorectal cancer (mCR...

    Authors: Pashtoon M. Kasi, Daisuke Kotani, Michael Cecchini, Kohei Shitara, Atsushi Ohtsu, Ramesh K. Ramanathan, Howard S. Hochster, Axel Grothey and Takayuki Yoshino

    Citation: BMC Cancer 2016 16:467

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  23. Content type: Research article

    To determine the appropriate time of concomitant chemotherapy administration after antiangiogenic treatment, we investigated the timing and effect of bevacizumab administration on vascular normalization of met...

    Authors: Bang-Bin Chen, Yen-Shen Lu, Ching-Hung Lin, Wei-Wu Chen, Pei-Fang Wu, Chao-Yu Hsu, Chih-Wei Yu, Shwu-Yuan Wei, Ann-Lii Cheng and Tiffany Ting-Fang Shih

    Citation: BMC Cancer 2016 16:466

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  24. Content type: Research article

    This phase I/II study aimed to determine the maximum tolerated dose (MTD) of nanoparticle albumin-bound paclitaxel (nab ®-paclitaxel) plus cisplatin as treatment for metastatic nasophar...

    Authors: Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang and Li Zhang

    Citation: BMC Cancer 2016 16:464

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  25. Content type: Research article

    A survival paradox between Stage IIB/C and Stage IIIA colon cancers exists. It is unclear how adequate lymph nodes dissection (LN) and post-surgery chemotherapy contribute to the survival paradox. We intended ...

    Authors: Quyen D. Chu, Meijiao Zhou, Kaelen L. Medeiros, Prakash Peddi, Mindie Kavanaugh and Xiao-Cheng Wu

    Citation: BMC Cancer 2016 16:460

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  26. Content type: Research article

    Stereotactic body radiation therapy (SBRT) has been an emerging non-invasive treatment modality for patients with hepatocellular carcinoma (HCC) when curative treatments cannot be applied. In this study, we re...

    Authors: Jenny Que, Hsing-Tao Kuo, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin and Ching-Chieh Yang

    Citation: BMC Cancer 2016 16:451

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  27. Content type: Research article

    A randomized clinical trial has found that the addition of erlotinib to gemcitabine (GEM-E) for pancreatic cancer led to a modest increase in survival. The aim of this national population-based retrospective s...

    Authors: Sangjin Shin, Chan Mi Park, Hanbyeol Kwon and Kyung-Hun Lee

    Citation: BMC Cancer 2016 16:443

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  28. Content type: Research article

    To compare definitive radiochemotherapy with weekly administration of 30–40 mg/m2 of cisplatin to 100 mg/m2 of cisplatin on days 1, 22 and 43 for outcomes and toxicity in patients with squamous cell carcinoma of ...

    Authors: Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Katarina Karner, Primoz Strojan and Steven E Schild

    Citation: BMC Cancer 2016 16:437

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  29. Content type: Case report

    Sorafenib is a multi-targeted kinase inhibitor with a demonstrated activity in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC), and it is currently used for the treatment of these pathologies. On...

    Authors: Andrea Casadei Gardini, Elisa Chiadini, Luca Faloppi, Giorgia Marisi, Angelo Delmonte, Mario Scartozzi, Cristian Loretelli, Alessandro Lucchesi, Devil Oboldi, Alessandra Dubini, Giovanni Luca Frassineti and Paola Ulivi

    Citation: BMC Cancer 2016 16:429

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  30. Content type: Research article

    Pemetrexed is widely used for the treatment of advanced non-squamous non-small-cell lung cancer (NSCLC). However, factors that can predict the benefits of pemetrexed therapy have not yet been defined.

    Authors: Sojung Park, Hyun Jung Kim, Chang–Min Choi, Dae Ho Lee, Sang–We Kim, Jung–Shin Lee, Woo Sung Kim, Se Hoon Choi, Jin Kyung Rho and Jae Cheol Lee

    Citation: BMC Cancer 2016 16:417

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  31. Content type: Research article

    Randomized trials have shown a survival benefit for regorafenib over placebo in patients with metastatic colorectal cancer (mCRC) that progressed after standard therapies. We evaluated survival and safety outc...

    Authors: Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar and Thierry Andre

    Citation: BMC Cancer 2016 16:412

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    The Erratum to this article has been published in BMC Cancer 2016 16:518

  32. Content type: Research article

    Eribulin is a non-taxane, microtubule dynamics inhibitor that increases survival of patients with metastatic breast cancer. Although eribulin is well tolerated in patients with heavily pretreated disease, erib...

    Authors: Takayuki Kobayashi, Jyunichi Tomomatsu, Ippei Fukada, Tomoko Shibayama, Natsuki Teruya, Yoshinori Ito, Takuji Iwase, Shinji Ohno and Shunji Takahashi

    Citation: BMC Cancer 2016 16:404

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  33. Content type: Research article

    The adjuvant treatment for patients with isolated stromal invasion after radical hysterectomy and pelvic lymph node dissection (PLND) in FIGO stage IB1 and IIA1 cervical carcinoma has not been established. Thi...

    Authors: Lei Li, XiaoYan Song, RuoNan Liu, Nan Li, Ye Zhang, Yan Cheng, HongTu Chao and LiYing Wang

    Citation: BMC Cancer 2016 16:403

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  34. Content type: Research article

    The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the uti...

    Authors: Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi…

    Citation: BMC Cancer 2016 16:396

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  35. Content type: Case report

    Multiple new targeted agents have been developed for patients with human epidermal growth factor receptor type 2 (HER2) – positive breast cancer. Patients with HER2– positive breast cancer will develop brain m...

    Authors: Koichi Mitsuya, Junichiro Watanabe, Yoko Nakasu, Nakamasa Hayashi, Hideyuki Harada and Ichiro Ito

    Citation: BMC Cancer 2016 16:391

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  36. Content type: Case report

    Lymphangioleiomyomatosis (LAM) is a rare idiopathic disorder that occurs in women of childbearing age, and consists of a diffuse proliferation of abnormal smooth muscle cells along the thoracic and abdominal l...

    Authors: Kensuke Suzuki, Kazunori Nagasaka, Katsutoshi Oda, Hiroyuki Abe, Daichi Maeda, Yoko Matsumoto, Takahide Arimoto, Kei Kawana, Masashi Fukayama, Yutaka Osuga and Tomoyuki Fujii

    Citation: BMC Cancer 2016 16:390

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  37. Content type: Research article

    Bone metastasis is relatively uncommon in gastric cancer patients, but its incidence has been rising. Early detection of bone metastasis is important in preventing complications related to bone metastasis such...

    Authors: Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim and Sun Young Rha

    Citation: BMC Cancer 2016 16:385

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  38. Content type: Case report

    Cetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but se...

    Authors: Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs and Gaël Deplanque

    Citation: BMC Cancer 2016 16:384

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  39. Content type: Research article

    Male breast cancer (MBC) is rare. Given the paucity of randomized trials, treatment is generally extrapolated from female breast cancer guidelines.

    Authors: Piera Gargiulo, Matilde Pensabene, Monica Milano, Grazia Arpino, Mario Giuliano, Valeria Forestieri, Caterina Condello, Rossella Lauria and Sabino De Placido

    Citation: BMC Cancer 2016 16:375

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  40. Content type: Debate

    Every year 170,000 patients are diagnosed with brain metastases (BMs) in the United States. Traditionally, adjuvant whole brain radiotherapy (AWBRT) has been offered following local therapy with neurosurgery (...

    Authors: Gerald B. Fogarty, Angela Hong, Vinai Gondi, Bryan Burmeister, Kari Jacobsen, Serigne Lo, Elizabeth Paton, Brindha Shivalingam and John F. Thompson

    Citation: BMC Cancer 2016 16:372

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  41. Content type: Case report

    Cornelia de Lange syndrome is the prototype for cohesinopathy disorders, which are characterized by defects in chromosome segregation. Kidney malformations, including nephrogenic rests, are common in Cornelia ...

    Authors: Claudia Santoro, Andrea Apicella, Fiorina Casale, Angela La Manna, Martina Di Martino, Daniela Di Pinto, Cristiana Indolfi and Silverio Perrotta

    Citation: BMC Cancer 2016 16:365

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  42. Content type: Research article

    For patients with metastatic renal cell carcinoma (mRCC), targeted therapies have entered the market since 2006. The aims of this study were to evaluate the uptake and use of targeted therapies for mRCC in The...

    Authors: S. De Groot, S. Sleijfer, W. K. Redekop, E. Oosterwijk, J. B. A. G. Haanen, L. A. L. M. Kiemeney and C. A. Uyl-de Groot

    Citation: BMC Cancer 2016 16:364

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  43. Content type: Research article

    Primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL) is a distinct clinicopathological entity with a poor prognosis. Concurrent MYC and BCL2 overexpression predicts inferior prognos...

    Authors: Sehui Kim, Soo Jeong Nam, Dohee Kwon, Hannah Kim, Eunyoung Lee, Tae Min Kim, Dae Seog Heo, Sung Hye Park, Chul Woo Kim and Yoon Kyung Jeon

    Citation: BMC Cancer 2016 16:363

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  44. Content type: Research article

    To assess the impact of volumetric-modulated arc therapy (VMAT) compared with 3D-conformal radiotherapy (3DCRT) in patients with newly diagnosed high grade glioma in terms of toxicity, progression free surviva...

    Authors: Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Francesca Lobefalo, Antonella Stravato, Giuseppe D’Agostino, Ciro Franzese, Manuela Caroli, Lorenzo Bello and Marta Scorsetti

    Citation: BMC Cancer 2016 16:362

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  45. Content type: Research article

    Short-term starvation prior to chemotherapy administration protects mice against toxicity. We undertook dose-escalation of fasting prior to platinum-based chemotherapy to determine safety and feasibility in ca...

    Authors: Tanya B. Dorff, Susan Groshen, Agustin Garcia, Manali Shah, Denice Tsao-Wei, Huyen Pham, Chia-Wei Cheng, Sebastian Brandhorst, Pinchas Cohen, Min Wei, Valter Longo and David I. Quinn

    Citation: BMC Cancer 2016 16:360

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