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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 12 of 15

  1. Content type: Study protocol

    Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients’ quality of life. Single arm studies have shown that the dosimetric sparing of cr...

    Authors: Imran Petkar, Keith Rooney, Justin W. G. Roe, Joanne M. Patterson, David Bernstein, Justine M. Tyler, Marie A. Emson, James P. Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A. Bhide, Kate L. Newbold, Kevin J. Harrington, Emma Hall…

    Citation: BMC Cancer 2016 16:770

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  2. Content type: Study protocol

    The higher specificity of amino-acid positron emission tomography (AA-PET) in the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment-related alterations, in comparison to ...

    Authors: Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G. Baumert, Susan C. Short, Philipp T. Meyer, Wolfgang A. Weber and Anca-Ligia Grosu

    Citation: BMC Cancer 2016 16:769

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  3. Content type: Research article

    This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute...

    Authors: Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno and Jun Itami

    Citation: BMC Cancer 2016 16:757

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  4. Content type: Case report

    Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.

    Authors: Yang-Yang Shen, Hong-Wei Qin, Jian-Bo Zhang, Zhen-Dan Wang, Pang Li, Kai Pang, Bo Zhang, Sheng Li and Kai Cui

    Citation: BMC Cancer 2016 16:754

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  5. Content type: Research article

    Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, can be secreted by most cell types and released in perhaps all biological fluids. EVs contain multiple proteins, specific ...

    Authors: Yang Jin, Keyan Chen, Zongying Wang, Yan Wang, Jianzhi Liu, Li Lin, Yong Shao, Lihua Gao, Huihui Yin, Cong Cui, Zhaoli Tan, Liejun Liu, Chuanhua Zhao, Gairong Zhang, Ru Jia, Lijuan Du…

    Citation: BMC Cancer 2016 16:753

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  6. Content type: Research article

    Platinum-based systemic chemotherapy is considered the backbone for management of advanced urothelial carcinomas. However there is a lack of real world data on the use of such chemotherapy regimens, on patient...

    Authors: N. Houédé, G. Locker, C. Lucas, H. Soto Parra, U. Basso, D. Spaeth, R. Tambaro, L. Basterretxea, F. Morelli, C. Theodore, L. Lusuardi, N. Lainez, A. Guillot, G. Tonini, J. Bielle and X. Garcia Del Muro

    Citation: BMC Cancer 2016 16:752

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  7. Content type: Research article

    After the approval of pazopanib for the treatment of soft tissue sarcoma (STS), pneumothorax was reported as an unexpected adverse event during pazopanib treatment. The incidence and risk factors of pneumothor...

    Authors: Kenji Nakano, Noriko Motoi, Junichi Tomomatsu, Tabu Gokita, Keisuke Ae, Taisuke Tanizawa, Seiichi Matsumoto and Shunji Takahashi

    Citation: BMC Cancer 2016 16:750

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  8. Content type: Study protocol

    Cancer is the leading cause of premature death in Canada. In the last decade, important gains in cancer survival have been achieved by advances in adjuvant treatment. However, many oncologic treatments also re...

    Authors: Edith Pituskin, Mark Haykowsky, Margaret McNeely, John Mackey, Neil Chua and Ian Paterson

    Citation: BMC Cancer 2016 16:733

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  9. Content type: Study protocol

    Standard therapy for borderline-resectable pancreatic cancer in the UK is surgery with adjuvant chemotherapy, but rates of resection with clear margins are unsatisfactory and overall survival remains poor. Met...

    Authors: Daniel L. P. Holyoake, Elizabeth Ward, Derek Grose, David McIntosh, David Sebag-Montefiore, Ganesh Radhakrishna, Neel Patel, Michael Silva, Somnath Mukherjee, Victoria Y. Strauss, Lang’o Odondi, Emmanouil Fokas, Alan Melcher and Maria A. Hawkins

    Citation: BMC Cancer 2016 16:728

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  10. Content type: Case report

    Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5–10 % of cases. It has a poor prognosis, with direct invasion of ...

    Authors: Kana Hashimoto, Yusuke Okuma, Yukio Hosomi and Tsunekazu Hishima

    Citation: BMC Cancer 2016 16:718

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  11. Content type: Study protocol

    In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England and Wales, of whom 37 % underwent planned curative treatments. Potentially curative surgical resection is ass...

    Authors: M. A. West, L. Loughney, G. Ambler, B. D. Dimitrov, J. J. Kelly, M. G. Mythen, R. Sturgess, P. M. A. Calverley, A. Kendrick, M. P. W. Grocott and S. Jack

    Citation: BMC Cancer 2016 16:710

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  12. Content type: Research article

    Pancreatic adenocarcinoma is an aggressive disease with poor prognosis. In a randomized phase III trial, combination of Nab-paclitaxel (Nab-P) plus gemcitabine showed superior activity and efficacy in first-li...

    Authors: Ferdinando De Vita, Jole Ventriglia, Antonio Febbraro, Maria Maddalena Laterza, Alessio Fabozzi, Beatrice Savastano, Angelica Petrillo, Anna Diana, Guido Giordano, Teresa Troiani, Giovanni Conzo, Gennaro Galizia, Fortunato Ciardiello and Michele Orditura

    Citation: BMC Cancer 2016 16:709

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  13. Content type: Study protocol

    Neoadjuvant androgen deprivation therapy (ADT) has been suggested to confer several clinical benefits in patients with prostate cancer (PCa) undergoing transperineal prostate brachytherapy (TPPB). Unlike gonad...

    Authors: Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki and Shin Egawa

    Citation: BMC Cancer 2016 16:708

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  14. Content type: Research article

    The continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton”) and there is limited guidance of what this should be when little is known about this as...

    Authors: Gareth D. James, Stefan N. Symeonides, Jayne Marshall, Julia Young and Glen Clack

    Citation: BMC Cancer 2016 16:703

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  15. Content type: Research article

    As a multi-targeted anti-angiogenic receptor tyrosine kinase (RTK) inhibitor sunitinib (SUN) has been established for renal cancer and gastrointestinal stromal tumors. In advanced refractory esophagogastric ca...

    Authors: Markus Moehler, Irina Gepfner-Tuma, Annett Maderer, Peter C. Thuss-Patience, Joern Ruessel, Susanna Hegewisch-Becker, Hansjochen Wilke, Salah-Eddin Al-Batran, Mohammad-Reza Rafiyan, Florian Weißinger, Hans-Joachim Schmoll, Frank Kullmann, Ludwig Fischer von Weikersthal, Jens T. Siveke, Jens Weusmann, Stephan Kanzler…

    Citation: BMC Cancer 2016 16:699

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  16. Content type: Research article

    Human epidermal growth factor receptor-2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in 25 to 30 % of human breast cancers and is preferentially localized in lipid rafts. Stomatin ...

    Authors: Chin-Yau Chen, Chih-Yung Yang, Yen-Chung Chen, Chia-Wen Shih, Su-Shun Lo and Chi-Hung Lin

    Citation: BMC Cancer 2016 16:697

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  17. Content type: Research article

    To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients receive...

    Authors: Qi Zeng, Jie Wang, Xing Lv, Jie Li, Li-Jie Yin, Yan-Qun Xiang and Xiang Guo

    Citation: BMC Cancer 2016 16:693

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  18. Content type: Research article

    No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade...

    Authors: In-Jae Oh, Kyu-Sik Kim, Cheol-Kyu Park, Young-Chul Kim, Kwan-Ho Lee, Jin-Hong Jeong, Sun-Young Kim, Jeong-Eun Lee, Kye-Chul Shin, Tae-Won Jang, Hyun-Kyung Lee, Kye-Young Lee and Sung-Yong Lee

    Citation: BMC Cancer 2016 16:690

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  19. Content type: Research article

    Cisplatin-based treatment has been considered the standard treatment regimen of HNSCC. Cetuximab is an emerging target therapy that has potential therapeutic benefits over cisplatin. Nevertheless, curative eff...

    Authors: Jingwen Huang, Jing Zhang, Changle Shi, Lei Liu and Yuquan Wei

    Citation: BMC Cancer 2016 16:689

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  20. Content type: Research article

    Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the p...

    Authors: Jiafeng Shou, Zhigang Zhang, Yucheng Lai, Zhigang Chen and Jian Huang

    Citation: BMC Cancer 2016 16:687

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  21. Content type: Case report

    Dermatomyositis is an autoimmune myopathy characterized by proximal muscle weakness, muscle inflammation, and typical skin findings. It is a rare disease with an incidence of ~1/100 000. About 15–30 % of adult...

    Authors: Ondřej Kubeček, Tomáš Soukup, Adam Paulík and Jindřich Kopecký

    Citation: BMC Cancer 2016 16:684

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  22. Content type: Case report

    While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive rec...

    Authors: Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel and Sebastien Salas

    Citation: BMC Cancer 2016 16:679

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  23. Content type: Research article

    Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of neoplasm-related death in the United States. Several studies analyzed the efficacy of bevacizumab combined...

    Authors: Tobias Engel Ayer Botrel, Luciana Gontijo de Oliveira Clark, Luciano Paladini and Otávio Augusto C. Clark

    Citation: BMC Cancer 2016 16:677

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  24. Content type: Case report

    Pulmonary tumor thrombotic microangiopathy (PTTM), a rare complication of advanced cancer, is histologically characterized by tumor embolisms and fibrocellular intimal proliferation of small pulmonary arteries...

    Authors: Yui Takahashi, Hironori Uruga, Takeshi Fujii, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki and Kazuma Kishi

    Citation: BMC Cancer 2016 16:666

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  25. Content type: Research article

    Anemia is a major cause of morbidity in patients with cancer resulting in poor physical performance, prognosis and therapy outcome. The aim of this study is to assess the efficacy of intravenous (iv) iron admi...

    Authors: Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt and Alpaslan Mayadagli

    Citation: BMC Cancer 2016 16:661

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  26. Content type: Research article

    To investigate the prognostic value of oligo-recurrence in patients with brain-only oligometastases of non-small cell lung cancer (NSCLC) treated with stereotactic radiosurgery (SRS) or stereotactic radiothera...

    Authors: Yuzuru Niibe, Tetsuo Nishimura, Tetsuya Inoue, Katsuyuki Karasawa, Yoshiyuki Shioyama, Keiichi Jingu and Hiroki Shirato

    Citation: BMC Cancer 2016 16:659

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  27. Content type: Research article

    Multimodal treatment strategies – perioperative chemotherapy (CTx) and radical surgery – are currently accepted as treatment standard for locally advanced gastric cancer. However, the role of adjuvant postoper...

    Authors: Sven Lichthardt, Alexander Kerscher, Ulrich A. Dietz, Christian Jurowich, Volker Kunzmann, Burkhard H. A. von Rahden, Christoph-Thomas Germer and Armin Wiegering

    Citation: BMC Cancer 2016 16:650

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  28. Content type: Research article

    Streptozocin (STZ) based chemotherapy is recommended for patients with metastatic pancreatic neuroendocrine tumors (pNET). Temozolomide as mono- or combination therapy has been suggested to be a promising alte...

    Authors: Daniela Mueller, Sebastian Krug, Moushumee Majumder, Anja Rinke and Thomas Matthias Gress

    Citation: BMC Cancer 2016 16:645

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  29. Content type: Study protocol

    Neo-adjuvant chemoradiotherapy followed by surgery is the standard treatment with curative intent for oesophageal cancer patients, with 5-year overall survival rates up to 50 %. However, patients’ quality of l...

    Authors: Ruben T. H. M. Larue, Lien Van De Voorde, Maaike Berbée, Wouter J. C. van Elmpt, Ludwig J. Dubois, Kranthi M. Panth, Sarah G. J. A. Peeters, Ann Claessens, Wendy M. J. Schreurs, Marius Nap, Fabiënne A. R. M. Warmerdam, Frans L. G. Erdkamp, Meindert N. Sosef and Philippe Lambin

    Citation: BMC Cancer 2016 16:644

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  30. Content type: Study protocol

    This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for ...

    Authors: Naoya Murakami, Shingo Kato, Takashi Nakano, Takashi Uno, Takeharu Yamanaka, Hideyuki Sakurai, Ryoichi Yoshimura, Junichi Hiratsuka, Yuki Kuroda, Kotaro Yoshio and Jun Itami

    Citation: BMC Cancer 2016 16:640

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  31. Content type: Case report

    Conjunctival malignant melanoma (CMM) is a rare malignancy and in the advanced setting there is no effective treatment. In contrast, half of cutaneous melanomas have BRAF mutations and treatment with BRAF inhi...

    Authors: A. Maleka, G. Åström, P. Byström and G. J. Ullenhag

    Citation: BMC Cancer 2016 16:634

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  32. Content type: Research article

    Previous population-based studies have demonstrated an association between metformin use and improved survival among diabetic patients with cancer. We sought to analyze the effects of diabetes and its treatmen...

    Authors: Oscar Arrieta, Edgar Varela-Santoyo, Enrique Soto-Perez-de-Celis, Roberto Sánchez-Reyes, Martha De la Torre-Vallejo, Saé Muñiz-Hernández and Andrés F. Cardona

    Citation: BMC Cancer 2016 16:633

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  33. Content type: Research article

    The preferred chemotherapy method for gastric cancer continues to be matter of debate. We performed a meta-analysis to comparing prognosis and safety between perioperative chemotherapy and adjuvant chemotherap...

    Authors: Jun-hua Zhao, Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Bin Ma, Yu-chong Yang and Zhen-ning Wang

    Citation: BMC Cancer 2016 16:631

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  34. Content type: Case report

    Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for ...

    Authors: Paola Bordi, Marcello Tiseo, Giorgio Baldari and Sebastiano Buti

    Citation: BMC Cancer 2016 16:626

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  35. Content type: Research article

    Anthracyclines, as the most effective therapy, are the cornerstone of advanced stage sarcoma treatment. However, anthracyclines can also contribute to myocardial dysfunction and congestive heart failure, ultim...

    Authors: Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt and Daniel Pink

    Citation: BMC Cancer 2016 16:619

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  36. Content type: Research article

    Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we ...

    Authors: Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee

    Citation: BMC Cancer 2016 16:613

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  37. Content type: Case report

    Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor...

    Authors: Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen and Yu-Ping Li

    Citation: BMC Cancer 2016 16:593

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  38. Content type: Case report

    Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a com...

    Authors: Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak and Jun Suk Kim

    Citation: BMC Cancer 2016 16:588

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  39. Content type: Research article

    To identify predictors of prolonged or shortened progression-free survival (PFS) and overall survival (OS) among patients with metastatic renal cell carcinoma (mRCC) who received first-line targeted therapies.

    Authors: Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee and Jinsoo Chung

    Citation: BMC Cancer 2016 16:577

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  40. Content type: Case report

    HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated wi...

    Authors: Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux and Béatrice Weber

    Citation: BMC Cancer 2016 16:573

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  41. Content type: Debate

    Primary invasive Extramammary Paget’s vulvar disease is a rare tumor that is challenging to control. Wide surgical excision represents the standard treatment approach for Primary invasive Extramammary Paget’s ...

    Authors: Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias and George Kyrgias

    Citation: BMC Cancer 2016 16:563

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  42. Content type: Research article

    Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) has been studed in several cancers including cervical cancer. This study was designed to investigate the association of DW-MRI parameters with baseline ...

    Authors: Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda and Mitchell Kamrava

    Citation: BMC Cancer 2016 16:556

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  43. Content type: Case report

    Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disse...

    Authors: Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt and Gilles Dolivet

    Citation: BMC Cancer 2016 16:552

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  44. Content type: Case report

    Sorafenib is the standard first-line therapy for hepatocellular carcinoma (HCC) and probably ectopic hepatocellular carcinoma (EHCC) as well. No report involves a side effect of delayed high fever of sorafenib...

    Authors: Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang and Jianguo Sun

    Citation: BMC Cancer 2016 16:543

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  45. Content type: Research article

    The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than in Western countries, are well...

    Authors: Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li…

    Citation: BMC Cancer 2016 16:537

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  46. Content type: Research article

    The increasingly complex programs of contemporary cancer therapy emphasize the need for biological indicators of both therapeutic response and adverse effects. One example is combined-modality treatment aimed ...

    Authors: Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark and Anne Hansen Ree

    Citation: BMC Cancer 2016 16:536

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