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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 11 of 16

  1. Content type: Research article

    Cervical squamous cell carcinoma (CSCC) is the most frequent type among cervical cancers. Although the altered miRNA miR-30d expression and the amplified chromosome locus of MIR30D, 8q24, have been reported in...

    Authors: You Zhou, Yinghua Hao, Yuxia Li, Ruizhen Li, Ruifang Wu, Shubin Wang and Zhengyu Fang

    Citation: BMC Cancer 2017 17:230

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  2. Content type: Research article

    BMI has been suggested to impact on estrogenic activity in patients receiving anastrozole resulting in a reduced treatment efficacy in obese women. Current evidence in this regard is controversially discussed....

    Authors: A. Oberguggenberger, V. Meraner, M. Sztankay, B. Beer, G. Weigel, H. Oberacher, G. Kemmler, T. Czech, B. Holzner, L. Wildt, B. Sperner-Unterweger, M. Daniaux and M. Hubalek

    Citation: BMC Cancer 2017 17:226

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  3. Content type: Research article

    A high incidence of severe hematological adverse events during sunitinib treatment complicates decision making on dose and treatment cycle. We identified the characteristics of early-onset hematotoxicity of su...

    Authors: Renpei Kato, Yoichiro Kato, Tomohiko Matsuura, Mitsugu Kanehira, Ryo Takata and Wataru Obara

    Citation: BMC Cancer 2017 17:214

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  4. Content type: Research article

    We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy (#NCT02449538).

    Authors: Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang and Ho Yeong Lim

    Citation: BMC Cancer 2017 17:211

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  5. Content type: Study protocol

    In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called ‘elective dose’ in order to achieve control of clinically occult metastases....

    Authors: Sven van den Bosch, Tim Dijkema, Martina C. Kunze-Busch, Chris H. J. Terhaard, Cornelis P. J. Raaijmakers, Patricia A. H. Doornaert, Frank J. P. Hoebers, Marije R. Vergeer, Bas Kreike, Oda B. Wijers, Wim J. G. Oyen and Johannes H. A. M. Kaanders

    Citation: BMC Cancer 2017 17:208

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  6. Content type: Case report

    Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global...

    Authors: Johanna S. Song, Marianne Tawa, Nicole G. Chau, Thomas S. Kupper and Nicole R. LeBoeuf

    Citation: BMC Cancer 2017 17:200

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  7. Content type: Case report

    Collision tumors are uncommon but well described clinical entities composed of distinct tumor histologies occurring within the same anatomic site. Optimal management of patients with collision tumors remains h...

    Authors: Munveer S. Bhangoo, Jenny Y. Zhou, Siraj M. Ali, Russell Madison, Alexa B. Schrock and Carrie Costantini

    Citation: BMC Cancer 2017 17:197

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  8. Content type: Research article

    To evaluate the efficacy of cetuximab combined with modified FOLFIRI (mFOLFIRI) as a second-line treatment in metastatic gastric cancer patients and to identify potential biomarkers of clinical outcomes.

    Authors: Xin Liu, Weijian Guo, Wen Zhang, Jiliang Yin, Jun Zhang, Xiaodong Zhu, Tianshu Liu, Zhiyu Chen, Biyun Wang, Jianhua Chang, Fangfang Lv, Xiaonan Hong, Huijie Wang, Jialei Wang, Xinmin Zhao, Xianghua Wu…

    Citation: BMC Cancer 2017 17:188

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  9. Content type: Research article

    The purpose of this retrospective study was to determine whether RFA could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection.

    Authors: Jin Won Lee, Moon Hyung Choi, Young Joon Lee, Bandar Ali, Han Mo Yoo, Kyo Young Song and Cho Hyun Park

    Citation: BMC Cancer 2017 17:185

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  10. Content type: Research article

    In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to invest...

    Authors: Yan-Ru Feng, Jing Jin, Hua Ren, Xin Wang, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Xin-Fan Liu, Hui Fang, Zi-Hao Yu and Ye-Xiong Li

    Citation: BMC Cancer 2017 17:182

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  11. Content type: Study protocol

    A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an al...

    Authors: R. K. Charaghvandi, B. van Asselen, M. E. P. Philippens, H. M. Verkooijen, C. H. van Gils, P. J. van Diest, R. M. Pijnappel, M. G. G. Hobbelink, A. J. Witkamp, T. van Dalen, E. van der Wall, T. C. van Heijst, R. Koelemij, M. van Vulpen and H. J. G. D. van den Bongard

    Citation: BMC Cancer 2017 17:181

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  12. Content type: Study protocol

    This paper describes the multi-institutional prospective phase II clinical trial, SPARK: Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage Intrafraction Monitoring (KIM). KIM is a real-time image ...

    Authors: Paul Keall, Doan Trang Nguyen, Ricky O’Brien, Jeremy Booth, Peter Greer, Per Poulsen, Val Gebski, Andrew Kneebone and Jarad Martin

    Citation: BMC Cancer 2017 17:180

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  13. Content type: Research article

    Principal Treatment Centres (PTC) were established to provide age-appropriate care as well as clinical expertise for children and young people with cancer. However, little is known about the effects of special...

    Authors: Lesley Fairley, Daniel P. Stark, Daniel Yeomanson, Sally E. Kinsey, Adam W. Glaser, Susan V. Picton, Linda Evans and Richard G. Feltbower

    Citation: BMC Cancer 2017 17:168

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  14. Content type: Case report

    Cardiac metastasis from colorectal cancer is rare. There is little evidence supporting the effectiveness of chemotherapy, and standard therapy for metastatic cardiac tumors has not been established.

    Authors: Yoshiki Tsujii, Yoshito Hayashi, Akira Maekawa, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Hideki Iijima and Tetsuo Takehara

    Citation: BMC Cancer 2017 17:152

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  15. Content type: Research article

    High-dose (HD) chemotherapy with melphalan and autologous blood stem cell transplantation (ABSCT) for treatment of symptomatic multiple myeloma (MM) on an outpatient basis has been well established in the USA ...

    Authors: Katharina Lisenko, Sandra Sauer, Thomas Bruckner, Gerlinde Egerer, Hartmut Goldschmidt, Jens Hillengass, Johann W. Schmier, Sofia Shah, Mathias Witzens-Harig, Anthony D. Ho and Patrick Wuchter

    Citation: BMC Cancer 2017 17:151

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  16. Content type: Research article

    The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction of renal blood flow, as well as tubular epithelial cell toxicity. The objective of this study was to investigate the influenc...

    Authors: Kazumi Komaki, Tetsuro Kusaba, Mai Tanaka, Hiroshi Kado, Yayoi Shiotsu, Masahiro Matsui, Atsushi Shiozaki, Hiroshi Nakano, Takeshi Ishikawa, Hitoshi Fujiwara, Hideyuki Konishi, Yoshito Itoh, Satoaki Matoba and Keiichi Tamagaki

    Citation: BMC Cancer 2017 17:144

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  17. Content type: Research article

    There is emerging evidence showing a significant relationship between overall survival (OS) in non-small cell lung cancer NSCLC patients and weight change during chemotherapy or chemoradiation. A high neutroph...

    Authors: B. A. Derman, J. N. Macklis, M. S. Azeem, S. Sayidine, S. Basu, M. Batus, F. Esmail, J. A. Borgia, P. Bonomi and M. J. Fidler

    Citation: BMC Cancer 2017 17:141

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  18. Content type: Research article

    Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasophar...

    Authors: Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo and Xing Lv

    Citation: BMC Cancer 2017 17:134

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  19. Content type: Case report

    Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-b...

    Authors: Jian Ma, Quan-liang Yang and Yang Ling

    Citation: BMC Cancer 2017 17:132

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  20. Content type: Research article

    Due to the uncommon nature of primary spinal epidural lymphomas (PSELs), there has been little research looking at prognostic indicators for the tumor. To our knowledge, this is the largest study to evaluate p...

    Authors: Le Xiong, Ling-Min Liao, Jian-Wu Ding, Zhi-Lin Zhang, An-Wen Liu and Long Huang

    Citation: BMC Cancer 2017 17:131

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  21. Content type: Research article

    Despite our growing knowledge about the pathomechanisms of cancer cachexia, a whole clinical picture of the cachectic patient is still missing. Our objective was to evaluate the clinical characteristics in can...

    Authors: S. Schwarz, O. Prokopchuk, K. Esefeld, S. Gröschel, J. Bachmann, S. Lorenzen, H. Friess, M. Halle and M. E. Martignoni

    Citation: BMC Cancer 2017 17:130

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  22. Content type: Research article

    Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.

    Authors: Nicola Lehners, Isabelle Krämer, Maral Saadati, Axel Benner, Anthony D. Ho and Mathias Witzens-Harig

    Citation: BMC Cancer 2017 17:128

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  23. Content type: Case report

    Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement....

    Authors: Peter Mudry, Ondrej Slaby, Jakub Neradil, Jana Soukalova, Kristyna Melicharkova, Ondrej Rohleder, Marta Jezova, Anna Seehofnerova, Elleni Michu, Renata Veselska and Jaroslav Sterba

    Citation: BMC Cancer 2017 17:119

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  24. Content type: Research article

    The French EMS study prospectively collected exhaustive data from STS patients diagnosed in the Rhone-Alpes region from 2005 to 07.

    Authors: Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani and Jean-Yves Blay

    Citation: BMC Cancer 2017 17:111

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  25. Content type: Research article

    Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated...

    Authors: Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang and Yuan Li

    Citation: BMC Cancer 2017 17:105

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  26. Content type: Research article

    The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence and poor diagnosis in specific histological classifications of lung ...

    Authors: Li Zhang, Dan Liu, Lei Li, Dan Pu, Ping Zhou, Yuting Jing, He Yu, Yanwen Wang, Yihan Zhu, Yanqi He, Yalun Li, Shuang Zhao, Zhixin Qiu and Weimin Li

    Citation: BMC Cancer 2017 17:96

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  27. Content type: Research article

    The purpose of this study was to develop an effective nomogram capable of estimating the individual survival outcomes of patients with hepatocellular carcinoma (HCC), and compare the predictive accuracy and di...

    Authors: Gang Wan, Fangyuan Gao, Jialiang Chen, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng and Xianbo Wang

    Citation: BMC Cancer 2017 17:91

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  28. Content type: Research article

    The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rec...

    Authors: Qingguo Li, Yaqi Li, Weixing Dai, Sheng Wang, Ye Xu, Xinxiang Li and Sanjun Cai

    Citation: BMC Cancer 2017 17:80

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  29. Content type: Research article

    This study aimed to determine whether synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (IL-PCI) can be used to investigate the morphological characteristics of tumor neovascularization in ...

    Authors: Beilei Li, Yiqiu Zhang, Weizhong Wu, Guohao Du, Liang Cai, Hongcheng Shi and Shaoliang Chen

    Citation: BMC Cancer 2017 17:73

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  30. Content type: Research article

    Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinica...

    Authors: Nelli Roininen, Sari Takala, Kirsi-Maria Haapasaari, Arja Jukkola-Vuorinen, Johanna Mattson, Päivi Heikkilä and Peeter Karihtala

    Citation: BMC Cancer 2017 17:72

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  31. Content type: Research article

    CC-chemokine receptor seven (CCR7), a G-protein coupled receptor normally facilitating immune cells lymphatic homing, has recently been identified on several cancer cells in promoting invasion and lymphatic sp...

    Authors: Yu Xia, Li Liu, Ying Xiong, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Jiejie Xu and Jianming Guo

    Citation: BMC Cancer 2017 17:70

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  32. Content type: Study protocol

    Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular di...

    Authors: Livia S.A. Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Michele De Laurentiis, Massimo Rinaldo, Massimiliano D’Aiuto, Francesca Catalano, Giuseppe Banna, Francesco Ferrau’, Rosalba Rossello, Diego Serraino, Ettore Bidoli, Samuele Massarut, Guglielmo Thomas, Davide Gatti…

    Citation: BMC Cancer 2017 17:69

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  33. Content type: Research article

    Chemoradiotherapy (CRT) and bio-radiotherapy (BRT) are recognized as standard therapies for head and neck cancer (HNC). Aspiration pneumonia after CRT or BRT is a common late adverse event. Our aim in this stu...

    Authors: Sadayuki Kawai, Tomoya Yokota, Yusuke Onozawa, Satoshi Hamauchi, Akira Fukutomi, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Akiko Todaka, Takahiro Tsushima, Yukio Yoshida, Yosuke Kito, Keita Mori and Hirofumi Yasui

    Citation: BMC Cancer 2017 17:59

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  34. Content type: Research article

    Cancer related thrombosis not only increases morbidity and mortality but also poses a significant financial burden on health care system. Risk of venous thromboembolism (VTE) in these patients substantially in...

    Authors: Muhammad Nauman Zahir, Quratulain Shaikh, Munira Shabbir-Moosajee and Adnan Abdul Jabbar

    Citation: BMC Cancer 2017 17:57

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  35. Content type: Research article

    Dysphagia is a significant side-effect following treatment for head and neck cancers, yet poor adherence to swallowing exercises is frequently reported in intervention studies. Behaviour change techniques (BCT...

    Authors: Roganie Govender, Christina H. Smith, Stuart A. Taylor, Helen Barratt and Benjamin Gardner

    Citation: BMC Cancer 2017 17:43

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  36. Content type: Research article

    Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). The efficacy and roles of combining temozolomide (TMZ) with whole brain radiotherapy (WBRT) in protection neurocognitiv...

    Authors: Xia Deng, Zhen Zheng, Baochai Lin, Huafang Su, Hanbin Chen, Shaoran Fei, Zhenghua Fei, Lihao Zhao, Xiance Jin and Cong-Ying Xie

    Citation: BMC Cancer 2017 17:42

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  37. Content type: Research article

    Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in ...

    Authors: Xiaoyan Han, Lijuan Wang, Hongfei Shi, Gaofeng Zheng, Jingsong He, Wenjun Wu, Jimin Shi, Guoqing Wei, Weiyan Zheng, Jie Sun, He Huang and Zhen Cai

    Citation: BMC Cancer 2017 17:40

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  38. Content type: Research article

    After analysis of minor RAS mutations (KRAS exon 3, 4/NRAS) in the FIRE-3 and PRIME studies, an expanded range of RAS mutations were established as a negative predictive marker for the efficacy of anti-EGFR antib...

    Authors: Izuma Nakayama, Eiji Shinozaki, Tomohiro Matsushima, Takeru Wakatsuki, Mariko Ogura, Takashi Ichimura, Masato Ozaka, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin, Nobuyuki Mizunuma and Kensei Yamaguchi

    Citation: BMC Cancer 2017 17:38

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  39. Content type: Research article

    This matched-pair study was initiated to validate the results of a retrospective study of 186 patients published in 2007 that compared whole-brain irradiation (WBI) alone and radiosurgery (RS) alone for up to ...

    Authors: Dirk Rades, Stefan Janssen, Liesa Dziggel, Oliver Blanck, Amira Bajrovic, Theo Veninga and Steven E. Schild

    Citation: BMC Cancer 2017 17:30

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  40. Content type: Research article

    This study evaluated the distribution pattern of the Ki67-labeling index (LI) among patients at a Chinese breast cancer center, and analyzed its prognostic significance in the 2015 St Gallen consensus breast c...

    Authors: Yue Hu, Ran Gu, Jinghua Zhao, Yaping Yang, Fengtao Liu, Liang Jin, Kai Chen, Haixia Jia, Hongli Wang, Qiang Liu, Fengxi Su and Weijuan Jia

    Citation: BMC Cancer 2017 17:28

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  41. Content type: Case report

    Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels ...

    Authors: Shouichi Okamoto, Shinsaku Togo, Ichiro Nagata, Kazue Shimizu, Yoshika Koinuma, Yukiko Namba, Jun Ito, Toshimasa Uekusa and Kazuhisa Takahashi

    Citation: BMC Cancer 2017 17:22

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  42. Content type: Research article

    To compare the efficacy of sorafenib and sunitinib with regard to overall survival (OS) and progression free survival (PFS) in Chinese patients with metastatic renal cell carcinoma (mRCC).

    Authors: Hai-Liang Zhang, Xi-Nan Sheng, Xue-Song Li, Hong-Kai Wang, Zhi-Hong Chi, Zhi-Song He, Ding-Wei Ye and Jun Guo

    Citation: BMC Cancer 2017 17:16

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  43. Content type: Case report

    Primary natural killer (NK)/T cell lymphoma of adrenal glands is an extremely rare tumor with aggressive clinical behavior. There have only been a few cases reported worldwide and the highest reported survival...

    Authors: Liu Hu, Weimin Xu, Mingwei Wang, Pan Wang, Guang Han and Chi Lin

    Citation: BMC Cancer 2017 17:15

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  44. Content type: Research article

    Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population s...

    Authors: Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa and Terenig Terjanian

    Citation: BMC Cancer 2017 17:13

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    The Erratum to this article has been published in BMC Cancer 2017 17:443

  45. Content type: Research article

    Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular carcinoma (HCC), but no data existed for early-stage ...

    Authors: Leung Li, Frankie KF Mo, Stephen L Chan, Edwin P Hui, Nelson SL Tang, Jane Koh, Linda KS Leung, Annette NY Poon, Joyce Hui, Cheuk M Chu, Kit F Lee, Brigette BY Ma, Paul BS Lai, Anthony TC Chan, Simon CH Yu and Winnie Yeo

    Citation: BMC Cancer 2017 17:8

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  46. Content type: Research article

    Discordance in hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) status between primary tumors and metastatic sites for breast cancer is well established. However, it is uncertain whic...

    Authors: Shlomit Strulov Shachar, Tanya Mashiach, Georgeta Fried, Karen Drumea, Noa Shafran, Hyman B. Muss and Gil Bar-Sela

    Citation: BMC Cancer 2017 17:7

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  47. Content type: Research article

    In head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery.

    Authors: Bülent Polat, Philipp Kaiser, Gisela Wohlleben, Thomas Gehrke, Agmal Scherzad, Matthias Scheich, Uwe Malzahn, Thomas Fischer, Dirk Vordermark and Michael Flentje

    Citation: BMC Cancer 2017 17:6

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  48. Content type: Research article

    Advanced age has been shown to be a factor predicting poor survival in patients with brain metastases (BM). There have been only a few studies focusing on stereotactic radiosurgery (SRS) for elderly BM patient...

    Authors: Shoji Yomo and Motohiro Hayashi

    Citation: BMC Cancer 2016 16:948

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  49. Content type: Case report

    Primary pancreatic leiomyosarcoma is a rare pancreatic malignancy; the clinical presentation and treatment is not well-characterized. Further, the molecular mechanisms underlying its pathogenesis are not known...

    Authors: Chao Lin, Liping Wang, Jiyao Sheng, Dan Zhang, Lianyue Guan, Kai Zhao and Xuewen Zhang

    Citation: BMC Cancer 2016 16:947

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