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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

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  1. Content type: Research article

    Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have s...

    Authors: Amit Kumar Ram, Biju Pottakat and Balasubramaniyan Vairappan

    Citation: BMC Cancer 2018 18:572

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  2. Content type: Research article

    Standard treatment for unresectable esophageal squamous cell carcinoma (ESCC) without distant metastasis is definitive chemoradiotherapy (dCRT), in which the incidence of esophageal fistula (EF) is reported to...

    Authors: Takeshi Kawakami, Takahiro Tsushima, Katsuhiro Omae, Hirofumi Ogawa, Hiromichi Shirasu, Yosuke Kito, Yukio Yoshida, Satoshi Hamauchi, Akiko Todaka, Nozomu Machida, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa and Hirofumi Yasui

    Citation: BMC Cancer 2018 18:573

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  3. Content type: Research article

    The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with oth...

    Authors: Ren Luo, Vincent W. C. Wu, Binghui He, Xiaoying Gao, Zhenxi Xu, Dandan Wang, Zhining Yang, Mei Li and Zhixiong Lin

    Citation: BMC Cancer 2018 18:575

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  4. Content type: Study protocol

    Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases ...

    Authors: David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau and Igor Latorzeff

    Citation: BMC Cancer 2018 18:566

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  5. Content type: Case report

    While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma ...

    Authors: Marin A. McDonald, Parag Sanghvi, Julie Bykowski and Gregory A. Daniels

    Citation: BMC Cancer 2018 18:549

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  6. Content type: Research article

    S-1 plus oxaliplatin(SOX) has been demonstrated to be effective and well tolerated for patients with metastatic gastric cancer. We conducted this phase II study to evaluate the feasibility of SOX as adjuvant c...

    Authors: Guoxiu Wang, Jiuda Zhao, Yan Song, Wen Zhang, Yongkun Sun, Aiping Zhou, Jing Huang, Feng Du and Lin Yang

    Citation: BMC Cancer 2018 18:547

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  7. Content type: Study protocol

    Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) has been a standard treatment option for locally advanced rectal cancer with improved local control. However, systemic recurrence...

    Authors: Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee and Suk-Hwan Lee

    Citation: BMC Cancer 2018 18:538

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  8. Content type: Case report

    Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcin...

    Authors: Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu and Nathan Jeffreys

    Citation: BMC Cancer 2018 18:543

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  9. Content type: Research article

    Melanoma is a rare, deadly disease without effective treatment options in China. Vemurafenib is a selective inhibitor of oncogenic BRAFV600 kinase approved in more than 90 countries, based on results obtained pri...

    Authors: Lu Si, Xiaoshi Zhang, Zhen Xu, Qiudi Jiang, Lilian Bu, Xuan Wang, Lili Mao, Weijiang Zhang, Nicole Richie and Jun Guo

    Citation: BMC Cancer 2018 18:520

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  10. Content type: Research article

    Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and ...

    Authors: Zhenhua Huang, Yantan Liu, Chen Yang, Xiaoyin Li, Changqie Pan, Jinjun Rao, Nailin Li, Wangjun Liao and Li Lin

    Citation: BMC Cancer 2018 18:515

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  11. Content type: Research article

    A computer-assisted diagnostic system for analyzing bone scans (BONENAVI) calculates the automated bone scan index (aBSI). Here we evaluated the aBSI as a prognostic imaging biomarker for men with metastatic c...

    Authors: Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Jikuya Ryosuke, Daisuke Yamashita, Shuko Yoneyama, Yumiko Yokomizo, Kazuki Kobayashi, Takeshi Kishida, Masahiro Yao and Hiroji Uemura

    Citation: BMC Cancer 2018 18:501

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  12. Content type: Research article

    This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer.

    Authors: Stephan P. Bauersfeld, Christian S. Kessler, Manfred Wischnewsky, Annette Jaensch, Nico Steckhan, Rainer Stange, Barbara Kunz, Barbara Brückner, Jalid Sehouli and Andreas Michalsen

    Citation: BMC Cancer 2018 18:476

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  13. Content type: Research article

    Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4–5 months. Since 2011, the overall survival of patients with stage IV melanoma has been significantl...

    Authors: Elham Vosoughi, Jee Min Lee, James R. Miller, Mehdi Nosrati, David R. Minor, Roy Abendroth, John W. Lee, Brian T. Andrews, Lewis Z. Leng, Max Wu, Stanley P. Leong, Mohammed Kashani-Sabet and Kevin B. Kim

    Citation: BMC Cancer 2018 18:490

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  14. Content type: Research article

    Transarterial chemoembolisation is the standard of care for intermediate stage (BCLC B) hepatocellular carcinoma, but it is challenging to decide when to repeat or stop treatment. Here we performed the first e...

    Authors: Aline Mähringer-Kunz, Arndt Weinmann, Irene Schmidtmann, Sandra Koch, Sebastian Schotten, Daniel Pinto dos Santos, Michael Bernhard Pitton, Christoph Dueber, Peter Robert Galle and Roman Kloeckner

    Citation: BMC Cancer 2018 18:489

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  15. Content type: Case report

    Adenocarcinomas of the oral cavity are rare neoplasms, and only four cases of primary colonic adenocarcinoma of the tongue have ever been described in literature. Very few information about chemotherapy sensit...

    Authors: Clizia Zichi, Marco Tampellini, Marcello Tucci, Cristina Sonetto, Chiara Baratelli, Maria P. Brizzi and Giorgio V. Scagliotti

    Citation: BMC Cancer 2018 18:470

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  16. Content type: Case report

    Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized t...

    Authors: Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A. Rezniczek and Clemens B. Tempfer

    Citation: BMC Cancer 2018 18:463

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  17. Content type: Research article

    5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, and Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer. Since data showing the influ...

    Authors: Stefan Munker, Michael Gerken, Petra Fest, Claudia Ott, Elisabeth Schnoy, Stefan Fichtner-Feigl, Philipp Wiggermann, Martin Vogelhuber, Wolfgang Herr, Christian Stroszczynski, Hans Jürgen Schlitt, Matthias Evert, Michael Reng, Monika Klinkhammer-Schalke and Andreas Teufel

    Citation: BMC Cancer 2018 18:455

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  18. Content type: Research article

    The objective of study was to determine the effect of anthracycline dose reduction and chemotherapy delays on 5-year overall survival in patients with stage I-III breast cancer, to establish the impact of mole...

    Authors: Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite and Elona Juozaityte

    Citation: BMC Cancer 2018 18:453

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  19. Content type: Research article

    Some patients develop recurrence after curative resection and adjuvant chemotherapy. S-1, an oral fluoropyrimidine, is one of the standard regimens in adjuvant chemotherapy, and is also used in first-line trea...

    Authors: Seiji Ito, Yasuo Ohashi and Mitsuru Sasako

    Citation: BMC Cancer 2018 18:449

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  20. Content type: Research article

    To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with small hepatocellular carcinoma(sHCC) who were ineligible for surgery or ablation therapies.

    Authors: Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu and Xuezhang Duan

    Citation: BMC Cancer 2018 18:451

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