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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 1 of 16

  1. Content type: Case report

    Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic met...

    Authors: Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe and David R. Mole

    Citation: BMC Cancer 2019 19:967

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  2. Content type: Research article

    Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. Limited data regarding clinicopath...

    Authors: Ryan W. Huey, Shalini Makawita, Lianchun Xiao, Aurelio Matamoros, Jeannelyn S. Estrella, Michael J. Overman, Gauri R. Varadhachary and Kanwal Raghav

    Citation: BMC Cancer 2019 19:965

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  3. Content type: Research article

    Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed the use of topotecan ...

    Authors: Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-on Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn and Suradej Hongeng

    Citation: BMC Cancer 2019 19:961

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  4. Content type: Case report

    Neuroendocrine tumors (NETs) are heterogeneous, widely distributed tumors arising from neuroendocrine cells. Gastrointestinal (GI)-NETs are the most common and NETs of the rectum represent 15, 2% of gastrointe...

    Authors: Gemma Bruera, Antonio Giuliani, Lucia Romano, Alessandro Chiominto, Alessandra Di Sibio, Stefania Mastropietro, Pierluigi Cosenza, Enrico Ricevuto, Mario Schietroma and Francesco Carlei

    Citation: BMC Cancer 2019 19:960

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  5. Content type: Study protocol

    Paclitaxel is used in second-line conventional chemotherapies to manage patients with unresectable advanced gastric cancer (GC). Paclitaxel-induced peripheral neuropathy is a known adverse event leading to tre...

    Authors: Hiroaki Tanioka, Takeshi Nagasaka, Futoshi Uno, Masafumi Inoue, Hiroyuki Okita, Yosuke Katata, Hiromitsu Kanzaki, Hidekazu Kuramochi, Hironaga Satake, Yoshiaki Shindo, Akira Doi, Jyunichiro Nasu, Haruhiro Yamashita and Yoshiyuki Yamaguchi

    Citation: BMC Cancer 2019 19:941

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  6. Content type: Research article

    The clinical target volume (CTV) for postoperative radiotherapy for thoracic esophageal squamous cell carcinoma (TESCC) needs to be defined. The study aim was to map metastatic lymph nodes (LNMs) in a computed...

    Authors: Jing Yu, Wen Ouyang, Chunyang Li, Jiuling Shen, Yu Xu, Junhong Zhang and Conghua Xie

    Citation: BMC Cancer 2019 19:927

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  7. Content type: Case report

    Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is a rare Epstein-Barr virus (EBV) positive lymphoproliferative disorder included in the current World Health Organization (WHO) classification. It ar...

    Authors: Magda Zanelli, Maurizio Zizzo, Marco Montanaro, Vito Gomes, Giovanni Martino, Loredana De Marco, Giulio Fraternali Orcioni, Maria Paola Martelli and Stefano Ascani

    Citation: BMC Cancer 2019 19:916

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  8. Content type: Research article

    Oncoplastic surgery techniques lead to a rearrangement of the breast tissue and impede target definition during adjuvant radiotherapy (RT). The aim of this study was to assess local control rates after immedia...

    Authors: Kai Joachim Borm, Christine Schönknecht, Andrea Nestler, Markus Oechsner, Birgit Waschulzik, Stephanie Elisabeth Combs, Stefan Münch, Markus Niemeyer and Marciana Nona Duma

    Citation: BMC Cancer 2019 19:907

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  9. Content type: Review

    Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial ...

    Authors: Marissa B. Savoie, Angela Laffan, Cristina Brickman, Bevin Daniels, Anna Levin, Tami Rowen, James Smith, Erin L. Van Blarigan, Thomas A. Hope, J. Michael Berry-Lawhorn, Mekhail Anwar and Katherine Van Loon

    Citation: BMC Cancer 2019 19:906

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  10. Content type: Study protocol

    Prostate cancer (PCa) is the second most common cancer among men. New imaging-modalities have increased the diagnosed patients with limited number of metastasis after primary curative therapy, introducing so-c...

    Authors: Giulia Marvaso, Delia Ciardo, Giulia Corrao, Sara Gandini, Cristiana Fodor, Dario Zerini, Damaris Patricia Rojas, Matteo Augugliaro, Giuseppina Bonizzi, Salvatore Pece, Federica Cattani, Ketti Mazzocco, Francesco Alessandro Mistretta, Gennaro Musi, Sarah Alessi, Giuseppe Petralia…

    Citation: BMC Cancer 2019 19:903

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  11. Content type: Research article

    The impact of HER2-targeted therapy alone followed by the addition of chemotherapy at disease progression (PD) versus upfront combination was investigated by the SAKK 22/99 trial. The aim of this exploratory a...

    Authors: Sabine Schmid, Dirk Klingbiel, Stefan Aebi, Aron Goldhirsch, Christoph Mamot, Elisabetta Munzone, Franco Nolè, Christian Oehlschlegel, Olivia Pagani, Bernhard Pestalozzi, Christoph Rochlitz, Beat Thürlimann, Roger von Moos, Patrik Weder, Khalil Zaman and Thomas Ruhstaller

    Citation: BMC Cancer 2019 19:902

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  12. Content type: Study protocol

    Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...

    Authors: R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen, G. S. Sonke, P. Elkhuizen, M. W. M. van den Brekel, M. E. T. Tesselaar, C. Vens, J. H. M. Schellens, B. van Triest and M. Verheij

    Citation: BMC Cancer 2019 19:901

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  13. Content type: Research article

    This study aimed to evaluate the efficacy, side-effects and resistance mechanisms of first-line afatinib in a real-world setting.

    Authors: Gwo-Fuang Ho, Chee-Shee Chai, Adlinda Alip, Mohd Ibrahim A. Wahid, Matin Mellor Abdullah, Yoke-Ching Foo, Soon-Hin How, Adel Zaatar, Kai-Seng Lam, Kin-Wah Leong, John-Seng-Hooi Low, Mastura Md Yusof, Erica Chai-Yong Lee, Yok-Yong Toh and Chong-Kin Liam

    Citation: BMC Cancer 2019 19:896

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  14. Content type: Study protocol

    Bone metastases represent an important source of morbidity in cancer patients, mostly due to severe pain. Radiotherapy is an established symptomatic treatment for painful bone metastases, however, when convent...

    Authors: Carole Mercier, Piet Dirix, Piet Ost, Charlotte Billiet, Ines Joye, Peter Vermeulen, Yolande Lievens and Dirk Verellen

    Citation: BMC Cancer 2019 19:876

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  15. Content type: Research article

    This study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with pr...

    Authors: Ju-Li Lin, Jian-Xian Lin, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Chang-Ming Huang and Chao-Hui Zheng

    Citation: BMC Cancer 2019 19:873

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  16. Content type: Case report

    Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of p...

    Authors: Shinya Otani, Robert Nakayama, Tetsuya Sekita, Toru Hirozane, Naofumi Asano, Kazumasa Nishimoto, Aya Sasaki, Hajime Okita, Hideo Morioka, Masaya Nakamura and Morio Matsumoto

    Citation: BMC Cancer 2019 19:872

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  17. Content type: Research article

    Metformin is proven to improve the prognosis of various cancers, but it is unknown if metformin could ameliorate hypopharyngeal cancer in diabetes mellitus patients. This was a retrospective cohort study, and ...

    Authors: Yung-An Tsou, Wen-Dien Chang, Jian-Ji Lu, Tsu-Fang Wu, Hsiao-Ling Chen, Chuan-Mu Chen and Ming Hsui Tsai

    Citation: BMC Cancer 2019 19:862

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  18. Content type: Research article

    Selecting the appropriate patients to receive immunotherapy (IO) remains a challenge due to the lack of optimal biomarkers. The presence of liver metastases has been implicated as a poor prognostic factor in p...

    Authors: Mehmet Asim Bilen, Julie M. Shabto, Dylan J. Martini, Yuan Liu, Colleen Lewis, Hannah Collins, Mehmet Akce, Haydn Kissick, Bradley C. Carthon, Walid L. Shaib, Olatunji B. Alese, Conor E. Steuer, Christina Wu, David H. Lawson, Ragini Kudchadkar, Viraj A. Master…

    Citation: BMC Cancer 2019 19:857

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  19. Content type: Study protocol

    Despite recent advances in the treatment of multiple myeloma, the disease constantly relapses and is still considered as incurable. The current knowledge about the biological mechanisms underlying resistance t...

    Authors: Lina Benaniba, Benoit Tessoulin, Sabrina Trudel, Catherine Pellat-Deceunynck, Martine Amiot, Stéphane Minvielle, Pierre Antoine Gourraud, Sophie de Visme, Hervé Maisonneuve, Anne Lok, Steven Le Gouill, Philippe Moreau and Cyrille Touzeau

    Citation: BMC Cancer 2019 19:855

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  20. Content type: Research article

    Recent years have witnessed the rapid evolution of therapies in chronic-phase chronic myeloid leukemia (CP-CML). To assess the efficacy and tolerability of all reported front-line treatments for patients with ...

    Authors: Lu Tang, Huan Zhang, Yi-zhong Peng, Cheng-gong Li, Hui-wen Jiang, Min Xu, Heng Mei and Yu Hu

    Citation: BMC Cancer 2019 19:849

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  21. Content type: Research article

    To explore the association between biologically effective dose (BED) and survival rates in Child-Pugh A classification (CP-A) small hepatocellular carcinoma (HCC) patients treated with stereotactic body radiat...

    Authors: Jing Sun, Tao Zhang, Jia Wang, Wengang Li, Aimin Zhang, Weiping He, Dan Zhang, Dong Li, Junqiang Ding and Xuezhang Duan

    Citation: BMC Cancer 2019 19:846

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  22. Content type: Study protocol

    Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellen...

    Authors: David A. Palma, Robert Olson, Stephen Harrow, Rohann J. M. Correa, Famke Schneiders, Cornelis J. A. Haasbeek, George B. Rodrigues, Michael Lock, Brian P. Yaremko, Glenn S. Bauman, Belal Ahmad, Devin Schellenberg, Mitchell Liu, Stewart Gaede, Joanna Laba, Liam Mulroy…

    Citation: BMC Cancer 2019 19:816

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  23. Content type: Research article

    Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with...

    Authors: Jiyun Lee, Su Jin Lee, Kyung Kim, Seung Tae Kim, Kee-Taek Jang and Jeeyun Lee

    Citation: BMC Cancer 2019 19:805

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  24. Content type: Research article

    Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasm...

    Authors: Sridevi Hanaganahalli Basavaiah, Flora D. Lobo, Cheryl Sarah Philipose, Pooja K. Suresh, Saraswathy Sreeram, Hema Kini, Kausalya K. Sahu and Krishna Prasad

    Citation: BMC Cancer 2019 19:801

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  25. Content type: Research article

    The real-world incidence of chronic liver damage after transarterial chemoembolization (TACE) is unclear. LiverT, a retrospective, observational study, assessed liver function deterioration after a single TACE...

    Authors: Rebecca A. Miksad, Sadahisa Ogasawara, Fang Xia, Marc Fellous and Fabio Piscaglia

    Citation: BMC Cancer 2019 19:795

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  26. Content type: Research article

    PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between ...

    Authors: Axel Le Cesne, Sebastian Bauer, George D. Demetri, Guangyang Han, Luca Dezzani, Qasim Ahmad, Jean-Yves Blay, Ian Judson, Patrick Schöffski, Massimo Aglietta, Peter Hohenberger and Hans Gelderblom

    Citation: BMC Cancer 2019 19:794

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  27. Content type: Research article

    The treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC) remains controversial. In the present study, we compared the efficacy...

    Authors: Yanxin Chen, Jianping Wei, Jing Cai and Anwen Liu

    Citation: BMC Cancer 2019 19:793

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  28. Content type: Research article

    NETTER-1 trial demonstrated high efficacy and low toxicity of four cycles of Peptide Receptor Radionuclide Therapy (PRRT) in patients with metastasized NET. The present study evaluates the outcome of further P...

    Authors: S. Rudisile, A. Gosewisch, V. Wenter, M. Unterrainer, G. Böning, F. J. Gildehaus, W. P. Fendler, C. J. Auernhammer, C. Spitzweg, P. Bartenstein, A. Todica and H. Ilhan

    Citation: BMC Cancer 2019 19:788

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  29. Content type: Case report

    Trastuzumab emtansine (Kadcyla®, T-DM1) is an antibody-drug conjugate used to treat HER2 (human epidermal growth factor receptor 2) overexpressing metastatic breast cancer. In this report, we present the first...

    Authors: Chung Young Kim, Namju Kim, Ho-Kyung Choung and Sang In Khwarg

    Citation: BMC Cancer 2019 19:774

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  30. Content type: Research article

    Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...

    Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez

    Citation: BMC Cancer 2019 19:770

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  31. Content type: Research article

    Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...

    Authors: Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen and Xuelei Ma

    Citation: BMC Cancer 2019 19:767

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  32. Content type: Research article

    Evidence is emerging that older women may tolerate breast cancer therapies equally well as the young ones, providing that they receive good supportive care. It has also been reported that these patients remain...

    Authors: Janusz Kocik, Małgorzata Pajączek and Tomasz Kryczka

    Citation: BMC Cancer 2019 19:749

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  33. Content type: Case report

    Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment.

    Authors: Young Kwang Chae, Naira Saleem, Yoonhwan Roh, Haris Bilal, Pedro Viveiros, Bhoomika Sukhadia, Xiaoqi Lin, Muhammad Mubbashir Sheikh and Lee Chun Park

    Citation: BMC Cancer 2019 19:748

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  34. Content type: Research article

    There are different contouring guidelines for the clinical target volume (CTV) in anal cancer (AC) which vary concerning recommendations for radiation margins in different anatomical regions, especially on ing...

    Authors: Hendrik Dapper, Kilian Schiller, Stefan Münch, Jan C. Peeken, Kai Borm, Wolfgang Weber and Stephanie E. Combs

    Citation: BMC Cancer 2019 19:742

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  35. Content type: Research article

    Many older patients don’t receive appropriate oncological treatment. Our aim was to analyse whether there are age differences in the use of adjuvant chemotherapy and preoperative radiotherapy in patients with ...

    Authors: C. Sarasqueta, A. Perales, A. Escobar, M. Baré, M. Redondo, N. Fernández de Larrea, E. Briones, J. M. Piera, M. V. Zunzunegui and J. M. Quintana

    Citation: BMC Cancer 2019 19:735

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  36. Content type: Study protocol

    The prognosis of patients with metastatic or advanced sarcomas is poor and there are few options for treatment. Several studies have shown that gemcitabine and docetaxel (GD) combination chemotherapy has antit...

    Authors: Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Kotaro Nishida, Ryosuke Kuroda and Toshihiro Akisue

    Citation: BMC Cancer 2019 19:725

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  37. Content type: Research article

    The aim of this study was to assess the prognostic significance of preoperative systemic inflammation score (SIS) on patients with esophageal squamous cell carcinoma (ESCC).

    Authors: Xiaobin Fu, Tingting Li, Yaqing Dai and Jiancheng Li

    Citation: BMC Cancer 2019 19:721

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  38. Content type: Case report

    The epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer has been successfully treated with tyrosine kinase inhibitors (TKIs). Acquired resistance becomes a tough issue when pati...

    Authors: Jing Liu, Bo Jin, Hang Su, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2019 19:702

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  39. Content type: Research article

    Uncommon epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a rare subset of NSCLC. The aim of this study was to investigate the prevalence, characteristics, and clinical outc...

    Authors: J. Chantharasamee, N. Poungvarin, P. Danchaivijitr and S. Techawatanawanna

    Citation: BMC Cancer 2019 19:701

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  40. Content type: Research article

    The clinical impact of adjuvant radiotherapy on uterine sarcoma is unclear, and may depend on the histological type. Hence, the aim of this study was to evaluate clinical outcomes of adjuvant radiotherapy afte...

    Authors: Yuan Li, Haitao Ren and Junmei Wang

    Citation: BMC Cancer 2019 19:697

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  41. Content type: Research article

    The differences in progression-free survival (PFS) and cancer-specific survival (CSS) of metastatic renal cell carcinoma (mRCC) patients according to treatment, type of metastasis, and Heng criteria risk are u...

    Authors: Sung Han Kim, Dong-eun Lee, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee and Jinsoo Chung

    Citation: BMC Cancer 2019 19:688

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  42. Content type: Research article

    Several new treatment options have become available for pancreatic ductal adenocarcinoma (PDAC), but the support for their use for resectable, borderline resectable and locally advanced PDAC is unclear.

    Authors: Stefan Heinrich, Marc Besselink, Markus Moehler, Jean-Luc van Laethem, Michel Ducreux, Peter Grimminger, Jens Mittler, Hauke Lang, Manfred P. Lutz and Mickael Lesurtel

    Citation: BMC Cancer 2019 19:675

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  43. Content type: Research article

    To compare outcomes of high-risk human papilloma virus-related oropharyngeal squamous cell carcinoma (HPV OPSCC) treated with modern radiation treatment (RT) and daily image-guidance, staged with the 7th versus t...

    Authors: Kirsten van Gysen, Mark Stevens, Linxin Guo, Dasantha Jayamanne, David Veivers, Andrew Wignall, Leo Pang, Alexander Guminski, Adrian Lee, George Hruby, Paula Macleod, Alon Taylor and Thomas Eade

    Citation: BMC Cancer 2019 19:674

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  44. Content type: Study protocol

    Despite numerous guidelines, nearly one of two patients with cancer pain remains undertreated, thereby affecting their quality of life. Active patient involvement through Therapeutic Patient Education (TPE) is...

    Authors: Virginie Prevost, Natacha Heutte, Alexandra Leconte, Idlir Licaj, Claire Delorme and Bénédicte Clarisse

    Citation: BMC Cancer 2019 19:673

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  45. Content type: Research article

    Recurrent hepatocellular carcinoma (HCC) with a tumor thrombus (TT) extending into the inferior vena cava (IVC)/right atrium (RA) is generally regarded as a terminal-stage condition and there is no worldwide c...

    Authors: Jinrong Lou, Yong Li, Kangning Liang, Yutian Guo, Changlong Song, Lei Chen, Lifang Wang, Fei Wang, Li Zhang, Xia Chen, Xiangdong Xu and Mianshun Pan

    Citation: BMC Cancer 2019 19:668

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  46. Content type: Research article

    A standard therapy for locally advanced rectal cancer (LARC) includes fluoropyrimidine (FP)-based neoadjuvant chemoradiation (nCRT). Previous studies have inconsistently demonstrated that baseline neutrophil- ...

    Authors: Shaan Dudani, Horia Marginean, Patricia A. Tang, Jose G. Monzon, Soundouss Raissouni, Timothy R. Asmis, Rachel A. Goodwin, Joanna Gotfrit, Winson Y. Cheung and Michael M. Vickers

    Citation: BMC Cancer 2019 19:664

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  47. Content type: Research article

    There is no standard first-line chemotherapy for advanced gastric cancer with severe peritoneal metastasis. Although fluoropyrimidine is often used, its efficacy is limited, and it remains unclear whether comb...

    Authors: Hiroyuki Arai, Satoru Iwasa, Narikazu Boku, Masahiro Kawahira, Hirofumi Yasui, Toshiki Masuishi, Kei Muro, Keiko Minashi, Shuichi Hironaka, Naoki Fukuda, Daisuke Takahari and Takako Eguchi Nakajima

    Citation: BMC Cancer 2019 19:652

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