Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

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  1. Research article

    Cost-effectiveness analysis of XELOX versus XELOX plus bevacizumab for metastatic colorectal cancer in a public hospital school

    Metastatic colorectal cancer imposes a substantial burden on patients and society. Over the last years, progresses in the treatment have been made especially due to the introduction of monoclonal antibodies, s...

    Andrea Queiróz Ungari, Leonardo Régis Leira Pereira, Altacílio Aparecido Nunes and Fernanda Maris Peria

    BMC Cancer 2017 17:691

    Published on: 17 October 2017

  2. Research article

    A single-arm phase II study of nab-paclitaxel for patients with chemorefractory non-small cell lung cancer

    We aimed to evaluate the efficacy and safety of nab-paclitaxel in patients with refractory advanced non-small cell lung cancer who failed previous chemotherapy.

    Hisashi Tanaka, Kageaki Taima, Takeshi Morimoto, Yoshihito Tanaka, Masamichi Itoga, Kunihiko Nakamura, Akihito Hayashi, Mika Kumagai, Hideo Yasugahira, Megumi Mikuniya, Koichi Okudera, Shingo Takanashi and Sadatomo Tasaka

    BMC Cancer 2017 17:683

    Published on: 16 October 2017

  3. Research article

    The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma

    Diffusion-weighted MR imaging (DWI) has increasingly contributed to the management of nasopharyngeal carcinoma (NPC) patients. The objective of this paper was to explore the prognostic significance of apparent...

    Dan-Fang Yan, Wen-Bao Zhang, Shan-Bao Ke, Feng Zhao, Sen-Xiang Yan, Qi-Dong Wang and Li-Song Teng

    BMC Cancer 2017 17:678

    Published on: 11 October 2017

  4. Study protocol

    Enzalutamide versus abiraterone as a first-line endocrine therapy for castration-resistant prostate cancer (ENABLE study for PCa): a study protocol for a multicenter randomized phase III trial

    Both enzalutamide and abiraterone have demonstrated improved radiographic progression-free and overall survival for castration-resistant prostate cancer (CRPC) compared with placebo controls before docetaxel t...

    Kouji Izumi, Atsushi Mizokami, Mikio Namiki, Shogo Inoue, Nobumichi Tanaka, Yuko Yoshio, Kei Ishibashi, Manabu Kamiyama, Noriyasu Kawai, Hideki Enokida, Takashi Shima and Shizuko Takahara

    BMC Cancer 2017 17:677

    Published on: 10 October 2017

  5. Research article

    Respiratory-gated (4D) contrast-enhanced FDG PET-CT for radiotherapy planning of lower oesophageal carcinoma: feasibility and impact on planning target volume

    To assess the feasibility and potential impact on target delineation of respiratory-gated (4D) contrast-enhanced 18Fluorine fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT), in...

    Andrew Scarsbrook, Gillian Ward, Patrick Murray, Rebecca Goody, Karen Marshall, Garry McDermott, Robin Prestwich and Ganesh Radhakrishna

    BMC Cancer 2017 17:671

    Published on: 4 October 2017

  6. Research article

    Whole-lesion apparent diffusion coefficient histogram analysis: significance in T and N staging of gastric cancers

    Whole-lesion apparent diffusion coefficient (ADC) histogram analysis has been introduced and proved effective in assessment of multiple tumors. However, the application of whole-volume ADC histogram analysis i...

    Song Liu, Yujuan Zhang, Ling Chen, Wenxian Guan, Yue Guan, Yun Ge, Jian He and Zhengyang Zhou

    BMC Cancer 2017 17:665

    Published on: 2 October 2017

  7. Research article

    The outcome of prostate cancer patients treated with curative intent strongly depends on survival after metastatic progression

    Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as...

    Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel and Enrico Roggero

    BMC Cancer 2017 17:651

    Published on: 18 September 2017

  8. Research article

    A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer

    Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal...

    Kerry Lynn Reynolds, Philippe L. Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein Jr, Donna M. Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian…

    BMC Cancer 2017 17:646

    Published on: 12 September 2017

  9. Research article

    Neutrophil-lymphocyte ratio complements volumetric staging as prognostic factor in patients treated with definitive radiotherapy for oropharyngeal cancer

    Volumetric tumor staging has been shown as superior prognostic tool compared to the conventional TNM system in patients undergoing definitive intensity-modulated radiotherapy (IMRT) for head and neck cancer. R...

    Cédric Panje, Oliver Riesterer, Christoph Glanzmann and Gabriela Studer

    BMC Cancer 2017 17:643

    Published on: 11 September 2017

  10. Research article

    Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial

    The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The pat...

    Antonia Wenners, Jana Grambach, Juliane Koss, Nicolai Maass, Walter Jonat, Andreas Schmutzler and Christoph Mundhenke

    BMC Cancer 2017 17:632

    Published on: 6 September 2017

  11. Research article

    Development and external validation of nomograms to predict the risk of skeletal metastasis at the time of diagnosis and skeletal metastasis-free survival in nasopharyngeal carcinoma

    The skeletal system is the most common site of distant metastasis in nasopharyngeal carcinoma (NPC); various prognostic factors have been reported for skeletal metastasis, though most studies have focused on a...

    Lin Yang, Liangping Xia, Yan Wang, Shasha He, Haiyang Chen, Shaobo Liang, Peijian Peng, Shaodong Hong and Yong Chen

    BMC Cancer 2017 17:628

    Published on: 6 September 2017

  12. Research article

    The values of neutrophil-lymphocyte ratio and/or prostate-specific antigen in discriminating real Gleason score ≥ 7 prostate cancer from group of biopsy-based Gleason score ≤ 6

    The discrepant concordance between biopsy and radical prostatectomy (RP) specimen are well reported. To validate the clinical usefulness of neutrophil-lymphocyte ratio (NLR) in discriminating real GS ≥ 7 PCa f...

    Hanfeng Wang, Liangyou Gu, Yongjie Wu, Dan Feng, Junyao Duan, Xiaocong Wang, Yong Huang, Shengpan Wu, Jianwen Chen, Guangda Luo and Xu Zhang

    BMC Cancer 2017 17:629

    Published on: 6 September 2017

  13. Research article

    Role of adjuvant chemotherapy in locally advanced rectal cancer with ypT0-3N0 after preoperative chemoradiation therapy and surgery

    We aimed to explore the clinical benefit of adjuvant chemotherapy (AC) with fluoropyrimidine in patients with ypT0-3N0 rectal cancer after preoperative chemoradiation therapy (CRT) followed by total mesorectal...

    Chang Gon Kim, Joong Bae Ahn, Sang Joon Shin, Seung Hoon Beom, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Eun Ah Choe, Woong Sub Koom, Hyuk Hur, Byung Soh Min, Nam Kyu Kim, Hoguen Kim, Chan Kim, Inkyung Jung and Minkyu Jung

    BMC Cancer 2017 17:615

    Published on: 2 September 2017

  14. Research article

    Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study

    Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is opt...

    Sanghyuk Song, Hong-Gyun Wu, Chang Geol Lee, Ki Chang Keum, Mi Sun Kim, Yong Chan Ahn, Dongryul Oh, Hyo Jung Park, Sang-Wook Lee, Geumju Park, Sung Ho Moon, Kwan Ho Cho, Yeon-Sil Kim, Yongkyun Won, Young-Taek Oh, Won-Taek Kim…

    BMC Cancer 2017 17:598

    Published on: 30 August 2017

  15. Research article

    Propensity score matching analysis of a phase II study on simultaneous modulated accelerated radiation therapy using helical tomotherapy for nasopharyngeal carcinomas

    Using propensity score matching method (PSM) to evaluate the feasibility and clinical outcomes of simultaneous modulated accelerated radiation therapy (SMART) using helical tomotherapy (HT) in patients with na...

    Lei Du, Xin-Xin Zhang, Lin-Chun Feng, Bao-Lin Qu, Jing Chen, Jun Yang, Hai-Xia Liu, Shou-Ping Xu, Chuan-Bin Xie and Lin Ma

    BMC Cancer 2017 17:582

    Published on: 29 August 2017

  16. Research article

    Temporal influence of endocrine therapy with tamoxifen and chemotherapy on nutritional risk and obesity in breast cancer patients

    The effect of endocrine therapy with tamoxifen (TMX) on weight gain has been reported in the literature, but the outcomes are still controversial. Moreover, previous treatment options, such as chemotherapy (CT...

    Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Fernanda Silva Mazzutti, Marcelo de Almeida Maia, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva and Yara Cristina de Paiva Maia

    BMC Cancer 2017 17:578

    Published on: 29 August 2017

  17. Research article

    Adherence and feasibility of 2 treatment schedules of S-1 as adjuvant chemotherapy for patients with completely resected advanced lung cancer: a multicenter randomized controlled trial

    We conducted a multicenter randomized study of adjuvant S-1 administration schedules for surgically treated pathological stage IB-IIIA non-small cell lung cancer patients.

    Yoshinobu Hata, Takaharu Kiribayashi, Kazuma Kishi, Makoto Nagashima, Takefumi Nakayama, Shingo Ikeda, Mitsutaka Kadokura, Yuichi Ozeki, Hajime Otsuka, Yoshitaka Murakami, Keigo Takagi and Akira Iyoda

    BMC Cancer 2017 17:581

    Published on: 29 August 2017

  18. Study protocol

    Docetaxel, Cisplatin, and 5-fluorouracil (DCF) chemotherapy in the treatment of metastatic or unresectable locally recurrent anal squamous cell carcinoma: a phase II study of French interdisciplinary GERCOR and FFCD groups (Epitopes-HPV02 study)

    The squamous cell carcinoma of the anus (SCCA) is a rare disease, but its incidence is markedly increasing. About 15% of patients are diagnosed at metastatic stage, and more than 20% with a localized disease t...

    Stefano Kim, Marine Jary, Thierry André, Véronique Vendrely, Bruno Buecher, Eric François, François-Clément Bidard, Sarah Dumont, Emmanuelle Samalin, Didier Peiffert, Simon Pernot, Nabil Baba-Hamed, Farid El Hajbi, Olivier Bouché, Jérôme Desrame, Aurélie Parzy…

    BMC Cancer 2017 17:574

    Published on: 25 August 2017

  19. Research article

    Comparison of PSA value at last follow-up of patients who underwent low-dose rate brachytherapy and intensity-modulated radiation therapy for prostate cancer

    To compare the PSA value at the last follow-up of patients who underwent prostate low-dose rate brachytherapy (LDR-BT) with that of patients who underwent intensity-modulated radiation therapy (IMRT).

    Nobumichi Tanaka, Isao Asakawa, Yasushi Nakai, Makito Miyake, Satoshi Anai, Tomomi Fujii, Masatoshi Hasegawa, Noboru Konishi and Kiyohide Fujimoto

    BMC Cancer 2017 17:573

    Published on: 25 August 2017

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