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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 1 of 23

  1. Cancer patients with brain metastases (BMs) require multidisciplinary care, and treatment facility may play a role. This study aimed to investigate the impact of receiving treatment at academic centers on the ...

    Authors: Saber Amin, Michael Baine, Jane Meza and Chi Lin

    Citation: BMC Cancer 2021 21:387

    Content type: Research article

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  2. Gliomas are often associated with symptoms including seizures. Most patients with high-grade gliomas are treated with radiotherapy or radio-chemotherapy. Since irradiation causes inflammation, it may initially...

    Authors: Dirk Rades, Jaspar Witteler, Denise Olbrich, Peter Trillenberg, Steven E. Schild, Soeren Tvilsted and Troels W. Kjaer

    Citation: BMC Cancer 2021 21:386

    Content type: Study protocol

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  3. Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ducta...

    Authors: Gokce Askan, Ibrahim Halil. Sahin, Joanne F. Chou, Aslihan Yavas, Marinela Capanu, Christine A. Iacobuzio-Donahue, Olca Basturk and Eileen M. O’Reilly

    Citation: BMC Cancer 2021 21:385

    Content type: Research article

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  4. The dose perturbation effect of immobilization devices is often overlooked in intensity-modulated radiation therapy (IMRT) for breast cancer (BC). This retrospective study assessed the dosimetric effects of su...

    Authors: Ran Lv, Guangyi Yang, Yongzhi Huang and Yanhong Wang

    Citation: BMC Cancer 2021 21:384

    Content type: Research article

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  5. Epiplakin1 (Eppk1) is part of epidermal growth factor (EGF) signal and takes part in reorganization of cytoskeleton and cell proliferation. However, the role of Eppk1 in cervical cancer (CC) remains unknown.

    Authors: Dong Ma, Zhe Pan, Quan Chang, Jin-jin Zhang, Xiao Liu, Na Hua and Guo-Hua Li

    Citation: BMC Cancer 2021 21:377

    Content type: Research article

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  6. The abundance of immune and stromal cells in the tumor microenvironment (TME) is informative of levels of inflammation, angiogenesis, and desmoplasia. Radiomics, an approach of extracting quantitative features...

    Authors: Dooman Arefan, Ryan M. Hausler, Jules H. Sumkin, Min Sun and Shandong Wu

    Citation: BMC Cancer 2021 21:370

    Content type: Research article

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  7. A classification tree was used to analyze background factors for granulocyte colony-stimulating factor (G-CSF) preparation selection for febrile neutropenia (FN) prophylaxis in Japanese patients with non-Hodgk...

    Authors: Masahiro Yokoyama, Yoshiharu Kusano, Norihito Inoue, Noriko Nishimura, Yuko Mishima, Tomoyuki Nukada, Kiyohiko Hatake and Yasuhito Terui

    Citation: BMC Cancer 2021 21:358

    Content type: Research article

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  8. Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of Hodgkin lymphoma. There is limited data on treatment, management of refractory and relapsed disease, and long-term outcome. Man...

    Authors: Saad Akhtar, M. Shahzad Rauf, Yasser Khafaga, Amani Al-Kofide, Tusneem Ahmed M. Elhassan, Mahmoud A. Elshenawy, Juzer Nadri, Ali Hassan Mushtaq, Nasir Bakshi, Mohammed Shamayel, Suleiman Al-Sweedan, Sohail Sarwar and Irfan Maghfoor

    Citation: BMC Cancer 2021 21:351

    Content type: Research article

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  9. Despite the wide-spread use of immune checkpoint inhibitors (ICIs) in cancer chemotherapy, reports on patients developing acquired resistance (AR) to ICI therapy are scarce. Therefore, we first investigated th...

    Authors: Kazutaka Hosoya, Daichi Fujimoto, Takeshi Morimoto, Toru Kumagai, Akihiro Tamiya, Yoshihiko Taniguchi, Toshihide Yokoyama, Tadashi Ishida, Hirotaka Matsumoto, Katsuya Hirano, Ryota Kominami, Keisuke Tomii, Hidekazu Suzuki, Tomonori Hirashima, Satoshi Tanaka, Junji Uchida…

    Citation: BMC Cancer 2021 21:346

    Content type: Research article

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  10. Small-cell lung cancer (SCLC) is a highly proliferative, rapidly growing tumor with a poor prognosis, even in cases of limited disease (LD). Timely and accurate high-intensity therapy is necessary. For concurr...

    Authors: Seo Ree Kim, Ji Hyung Hong, Soo-Yoon Sung, Yeo Hyung Kim, Sang Hoon Chun, Hyun Woo Lee, Jung Soo Lee and Yoon Ho Ko

    Citation: BMC Cancer 2021 21:340

    Content type: Research article

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  11. Complete surgical remission (CSR) is the best predictor of overall survival (OS) for patients with metastatic osteosarcoma. However, metastasectomy has not been widely implemented in China in the last decade d...

    Authors: Lu Xie, Jie Xu, Xiaowei Li, Zuli Zhou, Hongqing Zhuang, Xin Sun, Kuisheng Liu, Xingyu Liu, Kunkun Sun, Yiming Wu, Jin Gu and Wei Guo

    Citation: BMC Cancer 2021 21:337

    Content type: Research article

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  12. Breast cancer is the most common cancer in women and the first cancer concerning mortality. Metastatic breast cancer remains a disease with a poor prognosis and about 30% of women diagnosed with an early stage...

    Authors: Mathilde Colombié, Pascal Jézéquel, Mathieu Rubeaux, Jean-Sébastien Frenel, Frédéric Bigot, Valérie Seegers and Mario Campone

    Citation: BMC Cancer 2021 21:333

    Content type: Study protocol

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  13. Crizotinib is the approved treatment for advanced non-small cell lung cancers (NSCLCs) of anaplastic lymphoma kinase (ALK) fusion. Failure of crizotinib treatment frequently involves drug intolerance or resist...

    Authors: Chih-Hsi Scott Kuo, Pi-Hung Tung, Allen Chung-Cheng Huang, Chin-Chou Wang, John Wen-Cheng Chang, Chien-Ying Liu, Fu-Tsai Chung, Yueh-Fu Fang, Yi-Ke Guo and Cheng-Ta Yang

    Citation: BMC Cancer 2021 21:309

    Content type: Research article

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  14. The enhanced knowledge of cancer biology has led to considerable advancement in systemic therapy for advanced breast cancer. Recently, studies showed that cyclin-dependent kinase (CDK) 4/6 inhibitor, when adde...

    Authors: Reem Alomran, Michelle White, Melissa Bruce, Mathias Bressel, Susan Roache, Lama Karroum, Gerard G. Hanna, Shankar Siva, Shom Goel and Steven David

    Citation: BMC Cancer 2021 21:303

    Content type: Study protocol

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  15. While molecularly targeted therapies and immune checkpoint inhibitors have improved the prognosis of advanced melanoma, biomarkers are required to monitor drug responses. Circulating tumor cells (CTCs) are rel...

    Authors: Yukiko Kiniwa, Kenta Nakamura, Asuka Mikoshiba, Atsuko Ashida, Yasuyuki Akiyama, Atsushi Morimoto and Ryuhei Okuyama

    Citation: BMC Cancer 2021 21:287

    Content type: Research article

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  16. To investigate the beam complexity and monitor unit (MU) efficiency issues for two different volumetric modulated arc therapy (VMAT) delivery technologies for patients with left-sided breast cancer (BC) and na...

    Authors: Chengqiang Li, Cheng Tao, Tong Bai, Zhenjiang Li, Ying Tong, Jian Zhu, Yong Yin and Jie Lu

    Citation: BMC Cancer 2021 21:261

    Content type: Research article

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  17. Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) (< 8.78 ng/mL) have special clinicopathologic characteristics and prognosis. The aim of this study was to apply a new method to establish and vali...

    Authors: Dongdong Zhou, Xiaoli Liu, Xinhui Wang, Fengna Yan, Peng Wang, Huiwen Yan, Yuyong Jiang and Zhiyun Yang

    Citation: BMC Cancer 2021 21:246

    Content type: Research article

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  18. AURA study reported 61% objective response rate and progression-free survival of 9.6 months with osimertinib in patients with EGFR/T790M+ non-small cell lung cancer. Due to lack of real-world data, we proposed...

    Authors: Mariano Provencio, Josefa Terrasa, Pilar Garrido, Rosario García Campelo, Francisco Aparisi, Pilar Diz, David Aguiar, Carlos García-Giron, Julia Hidalgo, Carlos Aguado, Jorge García González, Emilio Esteban, Lorenzo Gómez-Aldavarí, Teresa Moran, Oscar Juan, Luís Enrique Chara…

    Citation: BMC Cancer 2021 21:230

    Content type: Research article

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  19. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is an important cancer stem cell marker in gastric cancer. However, no detailed studies are available on LGR5 expression in poorly differentiated...

    Authors: Takehito Ehara, Takeshi Uehara, Tomoyuki Nakajima, Yasuhiro Kinugawa, Shota Kobayashi, Mai Iwaya, Hiroyoshi Ota and Yuji Soejima

    Citation: BMC Cancer 2021 21:228

    Content type: Research article

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  20. Due to recent concerns about the toxicity of trastuzumab emtansine (T-DM1) with stereotactic radiation, we assessed our institutional outcomes treating HER2-positive breast cancer brain metastases (BCBM) with T-D...

    Authors: Matthew N. Mills, Chelsea Walker, Chetna Thawani, Afrin Naz, Nicholas B. Figura, Sergiy Kushchayev, Arnold Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James Liu, Michael A. Vogelbaum, Peter A. Forsyth, Brian J. Czerniecki, Hatem H. Soliman, Hyo S. Han and Kamran A. Ahmed

    Citation: BMC Cancer 2021 21:223

    Content type: Research article

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  21. The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were homogeneously trea...

    Authors: Leif Hendrik Dröge, Steffen Hennies, Stephan Lorenzen, Lena-Christin Conradi, Henriette Quack, Torsten Liersch, Christian Helms, Miriam Alice Frank, Markus Anton Schirmer, Margret Rave-Fränk, Tim Beißbarth and Hendrik Andreas Wolff

    Citation: BMC Cancer 2021 21:219

    Content type: Research article

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  22. Advances in curative treatment for breast, colorectal, NSCLC and prostate cancer have led to improvements in cancer survival. Cancer treatment and recovery time can vary depending on the recommended modalities...

    Authors: Selina K. Wong, Jeremy Hamm, Aria Shokoohi, Colleen E. McGahan and Cheryl Ho

    Citation: BMC Cancer 2021 21:215

    Content type: Research article

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  23. The outcomes of immediate autologous breast reconstruction (IABR) after partial mastectomy followed by postoperative radiotherapy (RT) in terms of aesthetics, treatment-related complications, and local control...

    Authors: Shu-Ling Zhang, Jun Song, Yan-Ru Wang, Yi-Jia Guo, Jian-Zhu Zhao, Li Sun, Le-Tian Huang, Jie-Tao Ma and Cheng-Bo Han

    Citation: BMC Cancer 2021 21:214

    Content type: Research article

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  24. Lung cancer is most common among older individuals. However, polypharmacy and comorbidities, which are also more common in older individuals, can limit treatment options. Previous studies suggest that afatinib...

    Authors: Yuji Minegishi, Ou Yamaguchi, Shunichi Sugawara, Shoichi Kuyama, Satoshi Watanabe, Kazuhiro Usui, Masahide Mori, Osamu Hataji, Toshihiro Nukiwa, Satoshi Morita, Kunihiko Kobayashi and Akihiko Gemma

    Citation: BMC Cancer 2021 21:208

    Content type: Research article

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  25. The present study aims to evaluate the efficacy and safety of apatinib monotherapy or combination therapy for patients with advanced or recurrent biliary tract cancer (BTC).

    Authors: Caiyun Nie, Huifang Lv, Yishu Xing, Beibei Chen, Weifeng Xu, Jianzheng Wang and Xiaobing Chen

    Citation: BMC Cancer 2021 21:189

    Content type: Research article

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  26. The standard to ensure utmost cancer treatment is a prerequisite in national cancer plans for comprehensive cancer centers (CCCs) and ensured through multidisciplinary tumor boards (MTBs). Despite these being ...

    Authors: Monika Engelhardt, Gabriele Ihorst, Martin Schumacher, Michael Rassner, Laura Gengenbach, Mandy Möller, Khalid Shoumariyeh, Jakob Neubauer, Juliane Farthmann, Georg Herget and Ralph Wäsch

    Citation: BMC Cancer 2021 21:173

    Content type: Correspondence

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    The original article was published in BMC Cancer 2020 20:355

  27. Patients with cancer history are usually excluded from hepatocellular carcinoma (HCC) clinical trials. However, whether previous malignancy affects the oncological outcomes of HCC patients has not been fully a...

    Authors: Xuqi Sun, Lingling Li, Li Xu, Zhongguo Zhou, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Dandan Hu and Minshan Chen

    Citation: BMC Cancer 2021 21:147

    Content type: Research article

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  28. Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, 1 year of PCV is associated with significant toxicitie...

    Authors: Rachel J. Keogh, Razia Aslam, Maeve A. Hennessy, Zac Coyne, Bryan T. Hennessy, Oscar S. Breathnach, Liam Grogan and Patrick G. Morris

    Citation: BMC Cancer 2021 21:140

    Content type: Research article

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  29. Sarcoid lesions may mimic metastatic disease or recurrence in thyroid cancer (TC) patients as both diseases may affect the lungs and lymph nodes. We present the first study to systematically evaluate the clini...

    Authors: Vera Wenter, Nathalie L. Albert, Freba Ahmaddy, Marcus Unterrainer, Julia Hornung, Harun Ilhan, Peter Bartenstein, Christine Spitzweg, Nikolaus Kneidinger and Andrei Todica

    Citation: BMC Cancer 2021 21:139

    Content type: Research article

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  30. Stereotactic Body Radiation Therapy (SBRT) is an innovative modality based on high precision planning and delivery. Cancer with bone metastases and oligometastases are associated with an intermediate or good p...

    Authors: Sébastien Thureau, Vincent Marchesi, Marie-Hélène Vieillard, Lionel Perrier, Albert Lisbona, Marianne Leheurteur, Jean Tredaniel, Stéphane Culine, Bernard Dubray, Naïma Bonnet, Bernard Asselain, Julia Salleron and Jean-Christophe Faivre

    Citation: BMC Cancer 2021 21:117

    Content type: Study protocol

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  31. Irinotecan (IRI) and oxaliplatin (Ox) are standard therapeutic agents of the first-line treatments for metastatic colorectal cancer (mCRC). Previous meta-analyses of randomized controlled trials (RCTs) showed ...

    Authors: Sadayuki Kawai, Nozomi Takeshima, Yu Hayasaka, Akifumi Notsu, Mutsumi Yamazaki, Takanori Kawabata, Kentaro Yamazaki, Keita Mori and Hirofumi Yasui

    Citation: BMC Cancer 2021 21:116

    Content type: Research article

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  32. The optimal chest wall bolus regimen for postmastectomy radiotherapy (PMRT) remains unknown. We aimed to prospectively evaluate the use of a 1-mm-thick daily tissue-equivalent bolus in patients who received PM...

    Authors: Terufumi Kawamoto, Naoto Shikama, Chie Kurokawa, Naoya Hara, Masaki Oshima and Keisuke Sasai

    Citation: BMC Cancer 2021 21:109

    Content type: Research article

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  33. Giant cell tumor of bone (GCTB) is a rare osteoclastogenic stromal tumor. GCTB can rarely undergo malignant transformation. This post hoc analysis evaluated and classified malignancies in patients with GCTB wh...

    Authors: Emanuela Palmerini, Leanne L. Seeger, Marco Gambarotti, Alberto Righi, Peter Reichardt, Susan Bukata, Jean-Yves Blay, Tian Dai, Danielle Jandial and Piero Picci

    Citation: BMC Cancer 2021 21:89

    Content type: Research article

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  34. The role of capecitabine in neoadjuvant and adjuvant chemotherapy for early-stage triple-negative breast cancer (TNBC) is highly controversial. Our meta-analysis was designed to further elucidate the effects o...

    Authors: Xingfa Huo, Jinming Li, Fuxing Zhao, Dengfeng Ren, Raees Ahmad, Xinyue Yuan, Feng Du and Jiuda Zhao

    Citation: BMC Cancer 2021 21:78

    Content type: Research article

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  35. To investigate the clinical impact of sarcopenia and skeletal muscle density (SMD) among patients with metastatic pancreatic adenocarcinoma who underwent palliative first line gemcitabine-based chemotherapy.

    Authors: In-Ho Kim, Moon Hyung Choi, In Seok Lee, Tae Ho Hong and Myung Ah. Lee

    Citation: BMC Cancer 2021 21:77

    Content type: Research article

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  36. We have performed a head to head comparison of all-oral triplet combination of ixazomib, lenalidomide and dexamethasone (IRD) versus lenalidomide and dexamethasone (RD) in patients with relapsed and refractory...

    Authors: Jiri Minarik, Tomas Pika, Jakub Radocha, Alexandra Jungova, Jan Straub, Tomas Jelinek, Ludek Pour, Petr Pavlicek, Martin Mistrik, Lucie Brozova, Petra Krhovska, Katerina Machalkova, Pavel Jindra, Ivan Spicka, Hana Plonkova, Martin Stork…

    Citation: BMC Cancer 2021 21:73

    Content type: Research article

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  37. Outcomes are poorer in metastatic colorectal cancer (mCRC) patients with BRAF V600E mutations than those without it, but the effect of these mutations on treatment response is unclear. This real-world study asses...

    Authors: Nieves Martínez-Lago, Ana Fernández-Montes, Marta Covela, Elena M. Brozos, Juan De la Cámara, José C. Méndez Méndez, Mónica Jorge-Fernández, Antía Cousillas Castiñeiras, Cristina Reboredo, David Arias Ron, María L. Pellón Augusto, Paula González Villarroel, Begoña Graña, Mercedes Salgado Fernández, Alberto Carral Maseda, Francisca Vázquez Rivera…

    Citation: BMC Cancer 2021 21:64

    Content type: Research article

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  38. The prognosis of childhood acute lymphoblastic leukemia (ALL) is optimistic with a 5-year event-free survival (EFS) rate of 70–85%. However, the major causes of mortality are chemotherapy toxicity, infection a...

    Authors: Xin-Yu Li, Jia-Qiang Li, Xue-Qun Luo, Xue-Dong Wu, Xin Sun, Hong-Gui Xu, Chang-Gang Li, Ri-Yang Liu, Xiao-Fei Sun, Hui-Qin Chen, Yu-Deng Lin, Chi-kong LI and Jian-Pei Fang

    Citation: BMC Cancer 2021 21:59

    Content type: Research article

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  39. Cell-free DNA (cfDNA) genotyping in plasma using the cobas EGFR Mutation Test v2 (cobas) is the first liquid biopsy as a companion diagnosis to identify the EGFR T790M mutation (T790M) after the failure of tre...

    Authors: Yuko Oya, Tatsuya Yoshida, Kazuhiro Asada, Tetsuya Oguri, Naoki Inui, Sayako Morikawa, Kentaro Ito, Tomoki Kimura, Eiji Kunii, Takashi Matsui, Akihito Kubo, Tatsuo Kato, Takashi Abe, Takeshi Tsuda and Toyoaki Hida

    Citation: BMC Cancer 2021 21:57

    Content type: Research article

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  40. Epidermal growth factor receptor (EGFR) mutations in non–small-cell lung cancer predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). EGFR mutation types are associated with efficacy of EGFR TKIs. We inv...

    Authors: Sojung Park, Sung Yong Lee, Dojin Kim, Yun Su Sim, Jeong-Seon Ryu, Juwhan Choi, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee and Jung Hyun Chang

    Citation: BMC Cancer 2021 21:52

    Content type: Research article

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  41. Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population. We therefore did a real-world study using...

    Authors: Guiyi Ji, Ting Bao, Zhenzhen Li, Huairong Tang, Dan Liu, Ping Yang, Weimin Li and Yan Huang

    Citation: BMC Cancer 2021 21:50

    Content type: Research article

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  42. The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with do...

    Authors: Peng-Fei Zhang, Dan Xie and Qiu Li

    Citation: BMC Cancer 2021 21:35

    Content type: Research article

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  43. Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with a variety of advanced solid tumors. However, we not infrequently encounter patients ...

    Authors: Seo Ree Kim, Sang Hoon Chun, Joo Ri Kim, Sang-Yeob Kim, Jun Young Seo, Chan Kwon Jung, Bo-Mi Gil, Jeong-Oh Kim, Yoon Ho Ko, In Sook Woo, Byoung Yong Shim, Sook-Hee Hong and Jin Hyoung Kang

    Citation: BMC Cancer 2021 21:19

    Content type: Research article

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  44. Sequential inhibition of the vascular endothelial growth factor (VEGF) pathway with sorafenib could be useful for patients with metastatic renal cell carcinoma (RCC). Our aim was to determine the activity and ...

    Authors: Ana Elena Martín-Aguilar, Haidé Núñez-López and Juan C. Ramirez-Sandoval

    Citation: BMC Cancer 2021 21:16

    Content type: Research article

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  45. We hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases portal pressure and causes esophageal varices and variceal bleedings. We examined the incidence of high-risk...

    Authors: Jihye Lim, Ha Il Kim, Eunju Kim, Jiyoon Kim, Jihyun An, Seheon Chang, Seon-Ok Kim, Han chu Lee, Yung Sang Lee and Ju Hyun Shim

    Citation: BMC Cancer 2021 21:11

    Content type: Research article

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  46. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastroi...

    Authors: J. Smith-Palmer, O. R. Leeuwenkamp, J. Virk and N. Reed

    Citation: BMC Cancer 2021 21:10

    Content type: Research article

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  47. The prognosis of advanced oral cancer remains dismal. While multimodal therapy is beneficial, maintaining the quality of life of long-term survivors is important. Therefore, risk-adapted treatment regimens nee...

    Authors: Tomohiro Katagiri, Yoshio Ohyama, Hideo Miyamoto, Yuki Egawa, Toshiaki Moriki and Kazuki Hasegawa

    Citation: BMC Cancer 2020 20:1216

    Content type: Research article

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