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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 1 of 11

  1. Content type: Research article

    Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and valida...

    Authors: A. L. McCarthy, N. M. Peel, K. M. Gillespie, R. Berry, E. Walpole, P. Yates and R. E. Hubbard

    Citation: BMC Cancer 2018 18:892

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  2. Content type: Study protocol

    Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperat...

    Authors: Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink…

    Citation: BMC Cancer 2018 18:877

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  3. Content type: Research article

    The aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadene...

    Authors: Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang and Chang-Lin Zou

    Citation: BMC Cancer 2018 18:879

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  4. Content type: Study protocol

    To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50–60 Gy irradiation in breast cancer. However, these agents are also often used clinically f...

    Authors: Sadamoto Zenda, Takuhiro Yamaguchi, Tomoya Yokota, Tempei Miyaji, Tomoe Mashiko, Mari Tanaka, Masahito Yonemura, Misaki Takeno, Tomoka Okano, Toshikatsu Kawasaki, Yuko Nakamori, Shinobu Ishii, Sanae Shimada, Miyuki Kanamaru and Yosuke Uchitomi

    Citation: BMC Cancer 2018 18:873

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  5. Content type: Research article

    This was a prespecified secondary analysis of a randomized trial, which analyzed bone density following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT...

    Authors: Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus and Harald Rief

    Citation: BMC Cancer 2018 18:859

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  6. Content type: Study protocol

    Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumou...

    Authors: Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis and Peter Grimison

    Citation: BMC Cancer 2018 18:854

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  7. Content type: Case report

    High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited pub...

    Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang and Luying Liu

    Citation: BMC Cancer 2018 18:842

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  8. Content type: Research article

    To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

    Authors: Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao, Chao-Cheng Huang, Li-Hsueh Shih, Su-Wei Chen and Shau-Hsuan Li

    Citation: BMC Cancer 2018 18:837

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  9. Content type: Case report

    Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23–31 months. There are several treatment options including chemotherapy and sometimes en...

    Authors: Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli and Erika Viel

    Citation: BMC Cancer 2018 18:839

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  10. Content type: Case report

    Pneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.

    Authors: Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa and Kazuma Kishi

    Citation: BMC Cancer 2018 18:825

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  11. Content type: Research article

    To investigate the performance of quantitative indicators of MRI in early prediction of the response of gastrointestinal stromal tumor (GIST) to targeted therapy in a patient-based study.

    Authors: Lei Tang, Jian Li, Zi-Yu Li, Xiao-Ting Li, Ji-Fang Gong, Jia-Fu Ji, Ying-Shi Sun and Lin Shen

    Citation: BMC Cancer 2018 18:811

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  12. Content type: Research article

    There is still a debate regarding whether regimens combining irinotecan with platinum could replace regimens combining etoposide with platinum, as first-line chemotherapy for extensive-stage small cell lung ca...

    Authors: Fei Xu, Xiaoli Ren, Yuan Chen, Qianxia Li, Ruichao Li, Yu Chen and Shu Xia

    Citation: BMC Cancer 2018 18:808

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  13. Content type: Research article

    As stereotactic body radiation therapy (SBRT) has shown to be effective and safe in patients with hepatocellular carcinoma (HCC), the aim of our propensity score matched analysis was to evaluate the efficacy o...

    Authors: Dominik Bettinger, Eleni Gkika, Michael Schultheiss, Nicolas Glaser, Sophie Lange, Lars Maruschke, Nico Buettner, Simon Kirste, Ursula Nestle, Anca-Ligia Grosu, Robert Thimme and Thomas B. Brunner

    Citation: BMC Cancer 2018 18:807

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  14. Content type: Research article

    Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no studies are available on the application of hypo-radiotherapy to neoadjuvant radiotherap...

    Authors: Ning Li, Xin Wang, Yuan Tang, Dongbing Zhao, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Wenyang Liu, Yu Tang, Hui Fang, Yueping Liu, Yongwen Song, Shulian Wang, Jing Jin and Yexiong Li

    Citation: BMC Cancer 2018 18:803

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  15. Content type: Research article

    With the advent of novel drugs improved overall survival in patients with multiple myeloma, including patients who received up-front autologous stem cell transplantation (ASCT), has been reported from several ...

    Authors: Jon-Magnus Tangen, Geir Erland Tjønnfjord, Nina Gulbrandsen, Tobias Gedde-Dahl, Espen Stormorken, Kristina Anderson, Camilla Dao Vo and Fredrik Hellem Schjesvold

    Citation: BMC Cancer 2018 18:801

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  16. Content type: Case report

    Pulmonary is an uncommon site of extramedullary involvement in multiple myeloma (MM). Diffuse parenchymal amyloidosis as pulmonary manifestation of MM is even rarer. We report a rare case of diffuse parenchyma...

    Authors: Yin Liu, Zhibin Jin, Haiyan Zhang, Yingwei Zhang, Minke Shi, Fanqing Meng, Qi Sun and Hourong Cai

    Citation: BMC Cancer 2018 18:802

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  17. Content type: Research article

    To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib.

    Authors: Lu Yu, Haibo Wang, Darko Milijkovic, Xiaojun Huang and Qian Jiang

    Citation: BMC Cancer 2018 18:782

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  18. Content type: Research article

    The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non–small cell lung cancer (NSCLC), especially in ...

    Authors: Wenxiong Zhang, Yiping Wei, Dongliang Yu, Jianjun Xu and Jinhua Peng

    Citation: BMC Cancer 2018 18:780

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  19. Content type: Study protocol

    We present the study rationale and design of the JGOG3023 study, an open-label, parallel-arm, randomized, phase II trial that aimed to assess the efficacy and safety of chemotherapy with or without bevacizumab...

    Authors: Tadahiro Shoji, Shinichi Komiyama, Junzo Kigawa, Hiroshi Tanabe, Kazuyoshi Kato, Hiroaki Itamochi, Hiroyuki Fujiwara, Shoji Kamiura, Tetsutaro Hamano and Toru Sugiyama

    Citation: BMC Cancer 2018 18:771

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  20. Content type: Research article

    In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determin...

    Authors: Yvonne Huber, Franziska Bierling, Christian Labenz, Sandra Koch, Irene Schmidtmann, Roman Kloeckner, Sebastian Schotten, Tobias Huber, Hauke Lang, Marcus A. Woerns, Peter R. Galle, Arndt Weinmann and Julia Weinmann-Menke

    Citation: BMC Cancer 2018 18:774

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  21. Content type: Research article

    The primary aim of this trial was to determine the recommended phase II dose (RP2D) of weekly paclitaxel (wP) administered in combination with oral metronomic cyclophosphamide (OMC).

    Authors: Diane Pannier, Antoine Adenis, Emilie Bogart, Eric Dansin, Stéphanie Clisant-Delaine, Emilie Decoupigny, Anne Lesoin, Eric Amela, Sandrine Ducornet, Jean-Pierre Meurant, Marie-Cécile Le Deley and Nicolas Penel

    Citation: BMC Cancer 2018 18:775

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  22. Content type: Research article

    There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associat...

    Authors: Marie Viala, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L. Mott, Mary C. Schroeder, Alexandra Thomas and William Jacot

    Citation: BMC Cancer 2018 18:770

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  23. Content type: Research article

    Although lung adenocarcinoma with activating epidermal growth factor receptor (EGFR) mutations is common in never smokers, one-third of the patients are ever-smokers. We aimed to investigate the effect of cumu...

    Authors: In Ae Kim, Jong Sik Lee, Hee Joung Kim, Wan Seop Kim and Kye Young Lee

    Citation: BMC Cancer 2018 18:768

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  24. Content type: Research article

    The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcathete...

    Authors: Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa and Shuji Terai

    Citation: BMC Cancer 2018 18:756

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  25. Content type: Study protocol

    At time of diagnosis, less than 10% of patients with pancreatic adenocarcinomas (PDAC) are considered to be immediately operable (i.e. resectable). Considering their poor overall survival (OS), only tumours wi...

    Authors: Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel and Antonio Sa Cunha

    Citation: BMC Cancer 2018 18:762

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  26. Content type: Study protocol

    In the group of elderly patients (≥70 years) with metastatic pancreatic ductal adenocarcinoma (mPDAC), it is not known who benefits from intensive 1st line nab-paclitaxel/gemcitabine (nab-p/gem) combination ch...

    Authors: Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert and Nicolai Haertel

    Citation: BMC Cancer 2018 18:747

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  27. Content type: Research article

    A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamu...

    Authors: Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo and Deok-Hwan Yang

    Citation: BMC Cancer 2018 18:729

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  28. Content type: Study protocol

    Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignanc...

    Authors: Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner and Guillaume Vogin

    Citation: BMC Cancer 2018 18:719

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  29. Content type: Case report

    The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infect...

    Authors: Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira and Sandra Prazeres

    Citation: BMC Cancer 2018 18:708

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  30. Content type: Research article

    The aim of this study was to compare the efficacies of the XELOX and DOS regimens as preoperative chemotherapy in patients with locally advanced gastric cancer.

    Authors: Yan Wang, Xi Cheng, Yue-hong Cui, Jun Hou, Yuan Ji, Yi-hong Sun, Zhen-bin Shen, Feng-lin Liu and Tian-shu Liu

    Citation: BMC Cancer 2018 18:702

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  31. Content type: Research article

    Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast ca...

    Authors: Tetsu Hayashida, Hiromitsu Jinno, Katsuaki Mori, Hiroki Sato, Akira Matsui, Takashi Sakurai, Hiroaki Hattori, Shin Takayama, Masahiro Wada, Maiko Takahashi, Hirohito Seki, Tomoko Seki, Aiko Nagayama, Akiko Matsumoto and Yuko Kitagawa

    Citation: BMC Cancer 2018 18:701

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  32. Content type: Case report

    The advent of tyrosine kinase inhibitors (TKIs) has changed the treatment of RAI refractory, unresectable recurrent differentiated thyroid cancer (DTC), which was formerly treated with multidisciplinary remedies.

    Authors: Masayuki Tori and Toshirou Shimo

    Citation: BMC Cancer 2018 18:698

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  33. Content type: Research article

    Effective treatment options for advanced pancreatic cancer are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of nanoliposomal irinotecan with fluorouracil/leucovorin (nal-IRI + 5-FU...

    Authors: Danielle C. Glassman, Randze L. Palmaira, Christina M. Covington, Avni M. Desai, Geoffrey Y. Ku, Jia Li, James J. Harding, Anna M. Varghese, Eileen M. O’Reilly and Kenneth H. Yu

    Citation: BMC Cancer 2018 18:693

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  34. Content type: Research article

    To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast can...

    Authors: Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka and Masafumi Kurosumi

    Citation: BMC Cancer 2018 18:671

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  35. Content type: Case report

    No standard of care is established for plasmablastic lymphoma (PBL) and prognosis remains extremely poor, given that patients relapse early after chemotherapy and display resistance to commonly applied cytosta...

    Authors: Alessandro Broccoli, Laura Nanni, Vittorio Stefoni, Claudio Agostinelli, Lisa Argnani, Michele Cavo and Pier Luigi Zinzani

    Citation: BMC Cancer 2018 18:645

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  36. Content type: Research article

    This study was performed to examine the usefulness of combined androgen blockade (CAB) therapy with a gonadotropin-releasing hormone (GnRH) antagonist (CAB-antagonist therapy), instead of CAB therapy with GnRH...

    Authors: Takeshi Kashiwabara and Sayo Suda

    Citation: BMC Cancer 2018 18:619

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  37. Content type: Research article

    In the intensity-modulated radiotherapy (IMRT) era, great improvement has been made in survival of nasopharyngeal carcinoma (NPC). The 7th edition of the International Union against Cancer/American Joint Commi...

    Authors: Xing-Li Yang, Yan Wang, Shao-Bo Liang, Sha-Sha He, Dan-Ming Chen, Hai-Yang Chen, Li-Xia Lu and Yong Chen

    Citation: BMC Cancer 2018 18:606

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  38. Content type: Research article

    Resistance to preoperative radiotherapy is a major clinical problem in the treatment for locally advanced rectal cancer. The role of NDRG1 in resistance to ionizing radiation in rectal cancer has not been fully e...

    Authors: Soon-Chan Kim, Young-Kyoung Shin, Ye-Ah Kim, Sang-Geun Jang and Ja-Lok Ku

    Citation: BMC Cancer 2018 18:594

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  39. Content type: Research article

    Erlotinib is approved for the first line treatment of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer. Since the number of prospective studies in Caucasian patients treated...

    Authors: Zsolt Markóczy, Veronika Sárosi, Iveta Kudaba, Gabriella Gálffy, Ülkü Yilmaz Turay, Ahmet Demirkazik, Gunta Purkalne, Attila Somfay, Zsolt Pápai-Székely, Erzsébet Rásó and Gyula Ostoros

    Citation: BMC Cancer 2018 18:598

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  40. Content type: Study protocol

    High Dose Rate Brachytherapy (HDRB) boost is a well-established treatment for prostate cancer (PC). We describe the PROstate Multicentre External beam radioTHErapy Using Stereotactic boost (PROMETHEUS) study. ...

    Authors: Matthew Richardson, Mark Sidhom, Sarah Gallagher, Mel Grand, David Pryor, Joseph Bucci, Lee Wilton, Sankar Arumugam, Sarah Keats and Jarad M. Martin

    Citation: BMC Cancer 2018 18:588

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  41. Content type: Research article

    Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the facto...

    Authors: Lei Li, Xirun Wan, Fengzhi Feng, Tong Ren, Junjun Yang, Jun Zhao, Fang Jiang and Yang Xiang

    Citation: BMC Cancer 2018 18:585

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  42. Content type: Research article

    Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have s...

    Authors: Amit Kumar Ram, Biju Pottakat and Balasubramaniyan Vairappan

    Citation: BMC Cancer 2018 18:572

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  43. Content type: Research article

    Standard treatment for unresectable esophageal squamous cell carcinoma (ESCC) without distant metastasis is definitive chemoradiotherapy (dCRT), in which the incidence of esophageal fistula (EF) is reported to...

    Authors: Takeshi Kawakami, Takahiro Tsushima, Katsuhiro Omae, Hirofumi Ogawa, Hiromichi Shirasu, Yosuke Kito, Yukio Yoshida, Satoshi Hamauchi, Akiko Todaka, Nozomu Machida, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa and Hirofumi Yasui

    Citation: BMC Cancer 2018 18:573

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  44. Content type: Research article

    The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with oth...

    Authors: Ren Luo, Vincent W. C. Wu, Binghui He, Xiaoying Gao, Zhenxi Xu, Dandan Wang, Zhining Yang, Mei Li and Zhixiong Lin

    Citation: BMC Cancer 2018 18:575

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  45. Content type: Study protocol

    Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases ...

    Authors: David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau and Igor Latorzeff

    Citation: BMC Cancer 2018 18:566

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  46. Content type: Case report

    While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma ...

    Authors: Marin A. McDonald, Parag Sanghvi, Julie Bykowski and Gregory A. Daniels

    Citation: BMC Cancer 2018 18:549

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  47. Content type: Research article

    S-1 plus oxaliplatin(SOX) has been demonstrated to be effective and well tolerated for patients with metastatic gastric cancer. We conducted this phase II study to evaluate the feasibility of SOX as adjuvant c...

    Authors: Guoxiu Wang, Jiuda Zhao, Yan Song, Wen Zhang, Yongkun Sun, Aiping Zhou, Jing Huang, Feng Du and Lin Yang

    Citation: BMC Cancer 2018 18:547

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