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Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

Page 1 of 15

  1. Content type: Research article

    Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with...

    Authors: Jiyun Lee, Su Jin Lee, Kyung Kim, Seung Tae Kim, Kee-Taek Jang and Jeeyun Lee

    Citation: BMC Cancer 2019 19:805

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  2. Content type: Research article

    Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasm...

    Authors: Sridevi Hanaganahalli Basavaiah, Flora D. Lobo, Cheryl Sarah Philipose, Pooja K. Suresh, Saraswathy Sreeram, Hema Kini, Kausalya K. Sahu and Krishna Prasad

    Citation: BMC Cancer 2019 19:801

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  3. Content type: Research article

    The real-world incidence of chronic liver damage after transarterial chemoembolization (TACE) is unclear. LiverT, a retrospective, observational study, assessed liver function deterioration after a single TACE...

    Authors: Rebecca A. Miksad, Sadahisa Ogasawara, Fang Xia, Marc Fellous and Fabio Piscaglia

    Citation: BMC Cancer 2019 19:795

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  4. Content type: Research article

    PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between ...

    Authors: Axel Le Cesne, Sebastian Bauer, George D. Demetri, Guangyang Han, Luca Dezzani, Qasim Ahmad, Jean-Yves Blay, Ian Judson, Patrick Schöffski, Massimo Aglietta, Peter Hohenberger and Hans Gelderblom

    Citation: BMC Cancer 2019 19:794

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  5. Content type: Research article

    The treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC) remains controversial. In the present study, we compared the efficacy...

    Authors: Yanxin Chen, Jianping Wei, Jing Cai and Anwen Liu

    Citation: BMC Cancer 2019 19:793

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  6. Content type: Research article

    NETTER-1 trial demonstrated high efficacy and low toxicity of four cycles of Peptide Receptor Radionuclide Therapy (PRRT) in patients with metastasized NET. The present study evaluates the outcome of further P...

    Authors: S. Rudisile, A. Gosewisch, V. Wenter, M. Unterrainer, G. Böning, F. J. Gildehaus, W. P. Fendler, C. J. Auernhammer, C. Spitzweg, P. Bartenstein, A. Todica and H. Ilhan

    Citation: BMC Cancer 2019 19:788

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  7. Content type: Case report

    Trastuzumab emtansine (Kadcyla®, T-DM1) is an antibody-drug conjugate used to treat HER2 (human epidermal growth factor receptor 2) overexpressing metastatic breast cancer. In this report, we present the first...

    Authors: Chung Young Kim, Namju Kim, Ho-Kyung Choung and Sang In Khwarg

    Citation: BMC Cancer 2019 19:774

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  8. Content type: Research article

    Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...

    Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez

    Citation: BMC Cancer 2019 19:770

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  9. Content type: Research article

    Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...

    Authors: Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen and Xuelei Ma

    Citation: BMC Cancer 2019 19:767

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  10. Content type: Research article

    Evidence is emerging that older women may tolerate breast cancer therapies equally well as the young ones, providing that they receive good supportive care. It has also been reported that these patients remain...

    Authors: Janusz Kocik, Małgorzata Pajączek and Tomasz Kryczka

    Citation: BMC Cancer 2019 19:749

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  11. Content type: Case report

    Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment.

    Authors: Young Kwang Chae, Naira Saleem, Yoonhwan Roh, Haris Bilal, Pedro Viveiros, Bhoomika Sukhadia, Xiaoqi Lin, Muhammad Mubbashir Sheikh and Lee Chun Park

    Citation: BMC Cancer 2019 19:748

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  12. Content type: Research article

    There are different contouring guidelines for the clinical target volume (CTV) in anal cancer (AC) which vary concerning recommendations for radiation margins in different anatomical regions, especially on ing...

    Authors: Hendrik Dapper, Kilian Schiller, Stefan Münch, Jan C. Peeken, Kai Borm, Wolfgang Weber and Stephanie E. Combs

    Citation: BMC Cancer 2019 19:742

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  13. Content type: Research article

    Many older patients don’t receive appropriate oncological treatment. Our aim was to analyse whether there are age differences in the use of adjuvant chemotherapy and preoperative radiotherapy in patients with ...

    Authors: C. Sarasqueta, A. Perales, A. Escobar, M. Baré, M. Redondo, N. Fernández de Larrea, E. Briones, J. M. Piera, M. V. Zunzunegui and J. M. Quintana

    Citation: BMC Cancer 2019 19:735

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  14. Content type: Study protocol

    The prognosis of patients with metastatic or advanced sarcomas is poor and there are few options for treatment. Several studies have shown that gemcitabine and docetaxel (GD) combination chemotherapy has antit...

    Authors: Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Kotaro Nishida, Ryosuke Kuroda and Toshihiro Akisue

    Citation: BMC Cancer 2019 19:725

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  15. Content type: Research article

    The aim of this study was to assess the prognostic significance of preoperative systemic inflammation score (SIS) on patients with esophageal squamous cell carcinoma (ESCC).

    Authors: Xiaobin Fu, Tingting Li, Yaqing Dai and Jiancheng Li

    Citation: BMC Cancer 2019 19:721

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  16. Content type: Case report

    The epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer has been successfully treated with tyrosine kinase inhibitors (TKIs). Acquired resistance becomes a tough issue when pati...

    Authors: Jing Liu, Bo Jin, Hang Su, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2019 19:702

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  17. Content type: Research article

    Uncommon epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a rare subset of NSCLC. The aim of this study was to investigate the prevalence, characteristics, and clinical outc...

    Authors: J. Chantharasamee, N. Poungvarin, P. Danchaivijitr and S. Techawatanawanna

    Citation: BMC Cancer 2019 19:701

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  18. Content type: Research article

    The clinical impact of adjuvant radiotherapy on uterine sarcoma is unclear, and may depend on the histological type. Hence, the aim of this study was to evaluate clinical outcomes of adjuvant radiotherapy afte...

    Authors: Yuan Li, Haitao Ren and Junmei Wang

    Citation: BMC Cancer 2019 19:697

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  19. Content type: Research article

    The differences in progression-free survival (PFS) and cancer-specific survival (CSS) of metastatic renal cell carcinoma (mRCC) patients according to treatment, type of metastasis, and Heng criteria risk are u...

    Authors: Sung Han Kim, Dong-eun Lee, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee and Jinsoo Chung

    Citation: BMC Cancer 2019 19:688

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  20. Content type: Research article

    Several new treatment options have become available for pancreatic ductal adenocarcinoma (PDAC), but the support for their use for resectable, borderline resectable and locally advanced PDAC is unclear.

    Authors: Stefan Heinrich, Marc Besselink, Markus Moehler, Jean-Luc van Laethem, Michel Ducreux, Peter Grimminger, Jens Mittler, Hauke Lang, Manfred P. Lutz and Mickael Lesurtel

    Citation: BMC Cancer 2019 19:675

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  21. Content type: Research article

    To compare outcomes of high-risk human papilloma virus-related oropharyngeal squamous cell carcinoma (HPV OPSCC) treated with modern radiation treatment (RT) and daily image-guidance, staged with the 7th versus t...

    Authors: Kirsten van Gysen, Mark Stevens, Linxin Guo, Dasantha Jayamanne, David Veivers, Andrew Wignall, Leo Pang, Alexander Guminski, Adrian Lee, George Hruby, Paula Macleod, Alon Taylor and Thomas Eade

    Citation: BMC Cancer 2019 19:674

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  22. Content type: Study protocol

    Despite numerous guidelines, nearly one of two patients with cancer pain remains undertreated, thereby affecting their quality of life. Active patient involvement through Therapeutic Patient Education (TPE) is...

    Authors: Virginie Prevost, Natacha Heutte, Alexandra Leconte, Idlir Licaj, Claire Delorme and Bénédicte Clarisse

    Citation: BMC Cancer 2019 19:673

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  23. Content type: Research article

    Recurrent hepatocellular carcinoma (HCC) with a tumor thrombus (TT) extending into the inferior vena cava (IVC)/right atrium (RA) is generally regarded as a terminal-stage condition and there is no worldwide c...

    Authors: Jinrong Lou, Yong Li, Kangning Liang, Yutian Guo, Changlong Song, Lei Chen, Lifang Wang, Fei Wang, Li Zhang, Xia Chen, Xiangdong Xu and Mianshun Pan

    Citation: BMC Cancer 2019 19:668

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  24. Content type: Research article

    A standard therapy for locally advanced rectal cancer (LARC) includes fluoropyrimidine (FP)-based neoadjuvant chemoradiation (nCRT). Previous studies have inconsistently demonstrated that baseline neutrophil- ...

    Authors: Shaan Dudani, Horia Marginean, Patricia A. Tang, Jose G. Monzon, Soundouss Raissouni, Timothy R. Asmis, Rachel A. Goodwin, Joanna Gotfrit, Winson Y. Cheung and Michael M. Vickers

    Citation: BMC Cancer 2019 19:664

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  25. Content type: Research article

    There is no standard first-line chemotherapy for advanced gastric cancer with severe peritoneal metastasis. Although fluoropyrimidine is often used, its efficacy is limited, and it remains unclear whether comb...

    Authors: Hiroyuki Arai, Satoru Iwasa, Narikazu Boku, Masahiro Kawahira, Hirofumi Yasui, Toshiki Masuishi, Kei Muro, Keiko Minashi, Shuichi Hironaka, Naoki Fukuda, Daisuke Takahari and Takako Eguchi Nakajima

    Citation: BMC Cancer 2019 19:652

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  26. Content type: Study protocol

    In the management of patients with RAS wild-type metastatic colorectal cancer (mCRC), anti-epidermal growth factor receptor (EGFR) therapies have demonstrated a clinical benefit, with longer survival. However, th...

    Authors: Shang-Hung Chen, Hsiang-Lin Tsai, Jeng-Kai Jiang, Yung-Chuan Sung, Ching-Wen Huang, Yu-Min Yeh, Li-Tzong Chen and Jaw-Yuan Wang

    Citation: BMC Cancer 2019 19:640

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  27. Content type: Research article

    To evaluate the outcome of patients treated with stereotactic ablative body radiotherapy (SABR) with curative intent for stage I non-small cell lung cancer (NSCLC) with regard to local, regional and distant tu...

    Authors: Emilie Dubaere, Mathilde Goffaux, Marie Wanet, Benoit Bihin, Céline Gheldof, Anne-Sophie Demoulin, Antoine Bolly, Frederique Bustin, Fabrice Duplaquet, Paul-Emile Baugnee, Michel Gustin, Vincent Hers, Fabienne Maisin, Eric Marchand, Sebahat Ocak, Lionel Pirard…

    Citation: BMC Cancer 2019 19:639

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  28. Content type: Research article

    A key challenge in phase I trials is maintaining rapid escalation in order to avoid exposing too many patients to sub-therapeutic doses, while preserving safety by limiting the frequency of toxic events. Tradi...

    Authors: Bernard North, Hemant Mahendrakumar Kocher and Peter Sasieni

    Citation: BMC Cancer 2019 19:632

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  29. Content type: Research article

    This study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients with colorectal cancer (CRC).

    Authors: Zhangfa Song, Engeng Chen, Jun Qian, Jianbin Xu, Gaoyang Cao, Wei Zhou, Fei Wang, Min Chen, Dengyong Xu, Xiaowei Wang, Xiaotong Hu, Zhenyu Ju, Xuefeng Huang and Xiujun Cai

    Citation: BMC Cancer 2019 19:629

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  30. Content type: Research article

    Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical...

    Authors: Jian Xu, Gang Li, Shi Miao Zhu, Qi Liang Cai, Zhun Wang, Xiong Yang, Hong Tan Zhang and Yuan Jie Niu

    Citation: BMC Cancer 2019 19:625

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  31. Content type: Study protocol

    A cytotoxic chemotherapeutic regimen is not routinely recommended for frail elderly patients with unresectable colorectal cancer (CRC) because of susceptibility to treatment. Panitumumab is a monoclonal antibo...

    Authors: Tetsuji Terazawa, Takeshi Kato, Masahiro Goto, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Yoshihiro Matsubara and Taroh Satoh

    Citation: BMC Cancer 2019 19:623

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  32. Content type: Research article

    Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic synd...

    Authors: Huai-Hsuan Huang, Fei-Yun Chen, Wen-Chien Chou, Hsin-An Hou, Bor-Sheng Ko, Chien-Ting Lin, Jih-Luh Tang, Chi-Cheng Li, Ming Yao, Woei Tsay, Szu-Chun Hsu, Shang-Ju Wu, Chien-Yuan Chen, Shang-Yi Huang, Mei-Hsuan Tseng, Hwei-Fang Tien…

    Citation: BMC Cancer 2019 19:617

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  33. Content type: Research article

    Treatment of postmenopausal, hormone receptor-positive metastatic breast cancer (MBC) patients varies despite clear therapy guidelines, favoring endocrine treatment (ET). Aim of this study was to analyze persi...

    Authors: Markus Wallwiener, Naiba Nabieva, Manuel Feisst, Tanja Fehm, Johann de Waal, Mahdi Rezai, Bernd Baier, Gerold Baake, Hans-Christian Kolberg, Martin Guggenberger, Mathias Warm, Nadia Harbeck, Rachel Wuerstlein, Jörg-Uwe Deuker, Peter Dall, Barbara Richter…

    Citation: BMC Cancer 2019 19:611

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  34. Content type: Study protocol

    The prognosis of patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma is still dismal. There are no standard treatment strategies for these patients. Multidisciplinary team ...

    Authors: Xiaowen Liu, Jiejie Jin, Hong Cai, Hua Huang, Guangfa Zhao, Ye Zhou, Jianghong Wu, Chunyan Du, Ziwen Long, Yantian Fang, Mingze Ma, Guichao Li, Menglong Zhou, Jiliang Yin, Xiaodong Zhu, Ji zhu…

    Citation: BMC Cancer 2019 19:606

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  35. Content type: Research article

    Breast cancer with pathological non-complete response (non-pCR) after neoadjuvant chemotherapy (NAC) has a worse prognosis. Despite Neo-Bioscore has been validated as an independent prognostic model for breast...

    Authors: Uanderson Resende, César Cabello, Susana Oliveira Botelho Ramalho and Luiz Carlos Zeferino

    Citation: BMC Cancer 2019 19:601

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  36. Content type: Research article

    Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4–12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibi...

    Authors: Wenfeng Fang, Yihua Huang, Shaodong Hong, Zhonghan Zhang, Minghui Wang, Jiadi Gan, Wenjing Wang, Honglin Guo, Kai Wang and Li Zhang

    Citation: BMC Cancer 2019 19:595

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  37. Content type: Research article

    This study aimed to evaluate the feasibility and prognostic accuracy of incorporating the number of positive lymph nodes (PLN) into the TNM staging system for non-small cell lung cancer (NSCLC) patients.

    Authors: Xiaoling Shang, Jia Liu, Zhenxiang Li, Jiamao Lin and Haiyong Wang

    Citation: BMC Cancer 2019 19:591

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  38. Content type: Research article

    An accurate, reproducible, and comfortable immobilization device is essential for stereotactic radiotherapy (SBRT) in patients with lung cancer. This study compared thermoplastic masks (TMP) and vacuum cushion...

    Authors: Guofu Chen, Baiqiang Dong, Guoping Shan, Xiuqin Zhang, Huarong Tang, Yuchen Li, Zhenhua Wang, Wei Xu, Gang Xu, Guiming Yan, Feiyan Zhang, Xiao Hu, Jun Yang, Yujin Xu, Ming Chen and Jin Wang

    Citation: BMC Cancer 2019 19:583

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  39. Content type: Research article

    Eribulin mesylate is a nontaxane microtubule dynamics inhibitor approved for second-line (European Union) or third-line (United States) treatment of metastatic breast cancer. Two phase 2 single trials, evaluat...

    Authors: Lee Schwartzberg, Kristi McIntyre, Sharon Wilks, Shannon Puhalla, Joyce O’Shaughnessy, Erhan Berrak, Yaohua He and Linda Vahdat

    Citation: BMC Cancer 2019 19:578

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  40. Content type: Research article

    Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor rece...

    Authors: Ji Young Park, Seung Hun Jang, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Jinwon Seo, Chang Youl Lee, Yousang Ko and Yong-Bum Park

    Citation: BMC Cancer 2019 19:574

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  41. Content type: Research article

    Treatment options in metastatic breast cancer are limited. New therapies preferable with predictive biomarkers are needed. The aim of these trials was to investigate if gene copy number of the topoisomerase 1 ...

    Authors: Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Bent Ejlertsen, Erik Hugger Jakobsen and Dorte Lisbet Nielsen

    Citation: BMC Cancer 2019 19:573

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  42. Content type: Study protocol

    In men with a rising PSA following radical prostatectomy, salvage radiation therapy (SRT) offers a second chance for cure. Hormonal therapy can be combined with SRT in order to increase prostate tumor control,...

    Authors: Roche Kapoor, Matthew P. Deek, Riley McIntyre, Natasha Raman, Megan Kummerlowe, Iyah Chen, Matt Gaver, Hao Wang, Sam Denmeade, Tamara Lotan, Channing Paller, Mark Markowski, Michael Carducci, Mario Eisenberger, Tomasz M. Beer, Daniel Y. Song…

    Citation: BMC Cancer 2019 19:572

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  43. Content type: Research article

    To evaluate the impact of radiation dose on overall survival (OS) in patients treated with adjuvant chemoradiation (CRT) for pancreatic ductal adenocarcinoma (PDAC).

    Authors: Alessio G. Morganti, Francesco Cellini, Milly Buwenge, Alessandra Arcelli, Sergio Alfieri, Felipe A. Calvo, Riccardo Casadei, Savino Cilla, Francesco Deodato, Giancarmine Di Gioia, Mariacristina Di Marco, Lorenzo Fuccio, Federica Bertini, Alessandra Guido, Joseph M. Herman, Gabriella Macchia…

    Citation: BMC Cancer 2019 19:569

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  44. Content type: Case report

    Non-V600E BRAF mutated colorectal cancer (CRC) is a rare disease entity with specific clinical features. These tumors are less likely to have microsatellite instability than CRC with a V600E BRAF mutation and oft...

    Authors: Eduard Callebout, Suzane Moura Ribeiro, Stephanie Laurent, Marc De Man, Liesbeth Ferdinande, Kathleen B. M. Claes, Joni Van der Meulen and Karen P. Geboes

    Citation: BMC Cancer 2019 19:567

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  45. Content type: Research article

    Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) involvement is a rare disease with poor prognosis. This study aimed to evaluate the outcome of HCC patients receiving radiotherapy (RT) to IVC tumor...

    Authors: Tzu-Hui Pao, Wei-Ting Hsueh, Wei-Lun Chang, Nai-Jung Chiang, Yih-Jyh Lin, Yi-Sheng Liu and Forn-Chia Lin

    Citation: BMC Cancer 2019 19:560

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  46. Content type: Research article

    The future of combined immunotherapy (a PD-1/PD-L1 plus a CTLA-4 antagonist) is very bright. However, besides improving efficacy, combined therapy increases treatment-related adverse events (TRAEs). Also, the ...

    Authors: Lihu Gu, Parikshit Asutosh Khadaroo, Hui Su, Liya Kong, Liangliang Chen, Xianfa Wang, Xinlong Li, Hepan Zhu, Xin Zhong, Junhai Pan and Manman Chen

    Citation: BMC Cancer 2019 19:559

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