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BMC Cancer

Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Research article

    Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang

    Citation: BMC Cancer 2014 14:153

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  2. Content type: Research article

    Although the whole tumor cell vaccine can provide the best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete...

    Authors: Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei…

    Citation: BMC Cancer 2014 14:48

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  3. Content type: Research article

    Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers...

    Authors: Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja and Magnus Essand

    Citation: BMC Cancer 2014 14:30

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  4. Content type: Research article

    Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for over...

    Authors: Masanori Noguchi, Fukuko Moriya, Shigetaka Suekane, Rei Ohnishi, Satoko Matsueda, Tetsuro Sasada, Akira Yamada and Kyogo Itoh

    Citation: BMC Cancer 2013 13:613

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  5. Content type: Research article

    Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in c...

    Authors: Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour and Salem Chouaib

    Citation: BMC Cancer 2013 13:592

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  6. Content type: Research article

    We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here ...

    Authors: Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du, Yanan Zhu, Yayi Hou and Tingting Wang

    Citation: BMC Cancer 2013 13:582

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  7. Content type: Research article

    The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel

    Citation: BMC Cancer 2013 13:466

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  8. Content type: Research article

    High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...

    Authors: Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang and Qiang Ruan

    Citation: BMC Cancer 2013 13:459

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  9. Content type: Research article

    Investigating how the immune system functions during malignancies is crucial to developing novel therapeutic strategies. Natural killer (NK) cells, an important component of the innate immune system, play a vi...

    Authors: Rauf Bhat and Jean Rommelaere

    Citation: BMC Cancer 2013 13:367

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  10. Content type: Research article

    To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu

    Citation: BMC Cancer 2013 13:332

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  11. Content type: Research article

    Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette

    Citation: BMC Cancer 2013 13:324

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  12. Content type: Study protocol

    The quadrivalent human papillomavirus vaccine has been provided in Australia through the National Human Papillomavirus Vaccination Program since April 2007. National registry data demonstrates good coverage of...

    Authors: Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts and Suzanne M Garland

    Citation: BMC Cancer 2013 13:296

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  13. Content type: Research article

    It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly ...

    Authors: Sonia Cellot, Donna Johnston, David Dix, Marie-Chantal Ethier, Biljana Gillmeister, David Mitchell, Rochelle Yanofsky, Victor Lewis, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Lynette Bowes, Bruno Michon, Kent Stobart, Josee Brossard…

    Citation: BMC Cancer 2013 13:276

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  14. Content type: Research article

    Our previous studies have suggested that the primary impact of immune cell infiltration into the normal or pre-invasive tissue component is associated with the physical destruction of epithelial capsules, whic...

    Authors: Hongyan Yuan, Yi-Hsuan Hsiao, Yiyu Zhang, Jinlian Wang, Chao Yin, Rong Shen and Yiping Su

    Citation: BMC Cancer 2013 13:258

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  15. Content type: Research article

    Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating fac...

    Authors: Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev and Axel Ullrich

    Citation: BMC Cancer 2013 13:197

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  16. Content type: Research article

    Several human cancers are known to be associated with inflammation and/or viral infections. However, the influence of tumour-related inflammation on viral uptake is largely unknown. In this study we used oesop...

    Authors: Georgia Schäfer, Siti Kabanda, Beverly van Rooyen, Martina Bergant Marušič, Lawrence Banks and M Iqbal Parker

    Citation: BMC Cancer 2013 13:185

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  17. Content type: Research article

    High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a n...

    Authors: Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi and Yoko Nakasu

    Citation: BMC Cancer 2012 12:623

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  18. Content type: Study protocol

    Asbestos is the main cause of MPM in industrialized countries. Even since asbestos is banned in most developed countries, the peak wave of MPM incidence is anticipated for the next years due to the long latenc...

    Authors: Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder and Christoph Renner

    Citation: BMC Cancer 2012 12:615

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  19. Content type: Research article

    Identification of new cancer antigens is necessary for the efficient diagnosis and immunotherapy. A variety of tumor antigens have been identified by several methodologies. Among those antigens, cancer/testis ...

    Authors: Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama and Toshiro Ono

    Citation: BMC Cancer 2012 12:520

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