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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Research article

    For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of...

    Authors: Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira and Emmanuel Drouet

    Citation: BMC Cancer 2014 14:665

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  2. Content type: Research article

    Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new ant...

    Authors: Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu and SaeGwang Park

    Citation: BMC Cancer 2014 14:647

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  3. Content type: Research article

    It is largely accepted that specific immunological parameters in solid malignancies are associated with patient’s prognosis. Recently a correlation of macrophage polarization with histomorphological parameters...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam and Manuel Weber

    Citation: BMC Cancer 2014 14:522

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  4. Content type: Research article

    Regulatory T cells (Tregs) exhibit functional abnormalities in the context of hepatocellular carcinoma (HCC). The microRNAs (miRNAs) are identified as the key modulators in Tregs. This study was to explore whe...

    Authors: Long Chen, Huiying Ma, Heng Hu, Lingling Gao, Xuan Wang, Jiaqi Ma, Qiang Gao, Binbin Liu, Guomin Zhou and Chunmin Liang

    Citation: BMC Cancer 2014 14:489

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  5. Content type: Research article

    Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.

    Authors: Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma and Chenghai Zhao

    Citation: BMC Cancer 2014 14:480

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  6. Content type: Research article

    Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical di...

    Authors: Luigi Marongiu, Anna Godi, John V Parry and Simon Beddows

    Citation: BMC Cancer 2014 14:384

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  7. Content type: Research article

    Human papillomaviruses (HPV) are the causative agents of cervical cancer in women, which results in over 250 000 deaths per year. Presently there are two prophylactic vaccines on the market, protecting against...

    Authors: Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth and Edward P Rybicki

    Citation: BMC Cancer 2014 14:367

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  8. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is assoc...

    Authors: Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan and Hassan Ashktorab

    Citation: BMC Cancer 2014 14:296

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  9. Content type: Research article

    Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adju...

    Authors: Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao and Hu Chen

    Citation: BMC Cancer 2014 14:251

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  10. Content type: Research article

    The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver.

    Authors: Siân A Pugh, Rebecca J Harrison, John N Primrose and Salim I Khakoo

    Citation: BMC Cancer 2014 14:180

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  11. Content type: Research article

    Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang

    Citation: BMC Cancer 2014 14:153

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  12. Content type: Research article

    Although the whole tumor cell vaccine can provide the best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete...

    Authors: Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei…

    Citation: BMC Cancer 2014 14:48

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  13. Content type: Research article

    Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers...

    Authors: Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja and Magnus Essand

    Citation: BMC Cancer 2014 14:30

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  14. Content type: Research article

    Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for over...

    Authors: Masanori Noguchi, Fukuko Moriya, Shigetaka Suekane, Rei Ohnishi, Satoko Matsueda, Tetsuro Sasada, Akira Yamada and Kyogo Itoh

    Citation: BMC Cancer 2013 13:613

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  15. Content type: Research article

    Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in c...

    Authors: Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour and Salem Chouaib

    Citation: BMC Cancer 2013 13:592

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  16. Content type: Research article

    We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here ...

    Authors: Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du, Yanan Zhu, Yayi Hou and Tingting Wang

    Citation: BMC Cancer 2013 13:582

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  17. Content type: Research article

    The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel

    Citation: BMC Cancer 2013 13:466

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  18. Content type: Research article

    High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...

    Authors: Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang and Qiang Ruan

    Citation: BMC Cancer 2013 13:459

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  19. Content type: Research article

    Investigating how the immune system functions during malignancies is crucial to developing novel therapeutic strategies. Natural killer (NK) cells, an important component of the innate immune system, play a vi...

    Authors: Rauf Bhat and Jean Rommelaere

    Citation: BMC Cancer 2013 13:367

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  20. Content type: Research article

    To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu

    Citation: BMC Cancer 2013 13:332

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  21. Content type: Research article

    Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette

    Citation: BMC Cancer 2013 13:324

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  22. Content type: Study protocol

    The quadrivalent human papillomavirus vaccine has been provided in Australia through the National Human Papillomavirus Vaccination Program since April 2007. National registry data demonstrates good coverage of...

    Authors: Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts and Suzanne M Garland

    Citation: BMC Cancer 2013 13:296

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  23. Content type: Research article

    It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly ...

    Authors: Sonia Cellot, Donna Johnston, David Dix, Marie-Chantal Ethier, Biljana Gillmeister, David Mitchell, Rochelle Yanofsky, Victor Lewis, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Lynette Bowes, Bruno Michon, Kent Stobart, Josee Brossard…

    Citation: BMC Cancer 2013 13:276

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  24. Content type: Research article

    Our previous studies have suggested that the primary impact of immune cell infiltration into the normal or pre-invasive tissue component is associated with the physical destruction of epithelial capsules, whic...

    Authors: Hongyan Yuan, Yi-Hsuan Hsiao, Yiyu Zhang, Jinlian Wang, Chao Yin, Rong Shen and Yiping Su

    Citation: BMC Cancer 2013 13:258

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  25. Content type: Research article

    Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating fac...

    Authors: Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev and Axel Ullrich

    Citation: BMC Cancer 2013 13:197

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  26. Content type: Research article

    Several human cancers are known to be associated with inflammation and/or viral infections. However, the influence of tumour-related inflammation on viral uptake is largely unknown. In this study we used oesop...

    Authors: Georgia Schäfer, Siti Kabanda, Beverly van Rooyen, Martina Bergant Marušič, Lawrence Banks and M Iqbal Parker

    Citation: BMC Cancer 2013 13:185

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  27. Content type: Research article

    High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a n...

    Authors: Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi and Yoko Nakasu

    Citation: BMC Cancer 2012 12:623

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  28. Content type: Study protocol

    Asbestos is the main cause of MPM in industrialized countries. Even since asbestos is banned in most developed countries, the peak wave of MPM incidence is anticipated for the next years due to the long latenc...

    Authors: Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder and Christoph Renner

    Citation: BMC Cancer 2012 12:615

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  29. Content type: Research article

    Identification of new cancer antigens is necessary for the efficient diagnosis and immunotherapy. A variety of tumor antigens have been identified by several methodologies. Among those antigens, cancer/testis ...

    Authors: Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama and Toshiro Ono

    Citation: BMC Cancer 2012 12:520

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  30. Content type: Research article

    One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of...

    Authors: Ceyhan Ceran, Murat Cokol, Sultan Cingoz, Ipek Tasan, Mehmet Ozturk and Tamer Yagci

    Citation: BMC Cancer 2012 12:450

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  31. Content type: Research article

    Hepatoblastoma (HB) is the most common primary, malignant pediatric liver tumor in children. The treatment results for affected children have markedly improved in recent decades. However, the prognosis for hig...

    Authors: Shu-Cheng Zhang, Wei-Lin Wang, Wei-Song Cai, Kai-Lei Jiang and Zheng-Wei Yuan

    Citation: BMC Cancer 2012 12:427

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  32. Content type: Research article

    The role of Th17 cells in colorectal tumorigenesis and development still remains unclear, despite the fact that it has been established in the pathogenesis of autoimmune diseases.

    Authors: Jiansheng Wang, Kaiyu Xu, Jing Wu, Chenghua Luo, Yuchen Li, Xuebin Wu, Hong Gao, Guosheng Feng and Bao-Zhu Yuan

    Citation: BMC Cancer 2012 12:418

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  33. Content type: Research article

    Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase act...

    Authors: Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna and Martin Ruthardt

    Citation: BMC Cancer 2012 12:411

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  34. Content type: Research article

    Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors h...

    Authors: Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui and Han-Fei Ding

    Citation: BMC Cancer 2012 12:203

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  35. Content type: Research article

    WNT7a, a member of the Wnt ligand family implicated in several developmental processes, has also been reported to be dysregulated in some types of tumors; however, its function and implication in oncogenesis i...

    Authors: Alejandra B Ochoa-Hernández, Moisés Ramos-Solano, Ivan D Meza-Canales, Beatriz García-Castro, Mónica A Rosales-Reynoso, Judith A Rosales-Aviña, Esperanza Barrera-Chairez, Pablo C Ortíz-Lazareno, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Patricio Barros-Núñez and Adriana Aguilar-Lemarroy

    Citation: BMC Cancer 2012 12:60

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  36. Content type: Research article

    Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular...

    Authors: Marcela Braga Mansur, Rocio Hassan, Thayana C Barbosa, Alessandra Splendore, Patricia Y Jotta, José Andrés Yunes, Joseph L Wiemels and Maria S Pombo-de-Oliveira

    Citation: BMC Cancer 2012 12:9

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  37. Content type: Research article

    Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we ob...

    Authors: Maria Libera Ascierto, Andrea Worschech, Zhiya Yu, Sharon Adams, Jennifer Reinboth, Nanhai G Chen, Zoltan Pos, Rahul Roychoudhuri, Giovanni Di Pasquale, Davide Bedognetti, Lorenzo Uccellini, Fabio Rossano, Paolo A Ascierto, David F Stroncek, Nicholas P Restifo, Ena Wang…

    Citation: BMC Cancer 2011 11:451

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  38. Content type: Research article

    Cervical cancer continues to be an important worldwide health problem for women. Up to 35% of patients who are diagnosed with and appropriately treated for cervical cancer will recur and treatment results are ...

    Authors: Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Michelle Glasgow, Marta Bellone, Paola Todeschini, Luisa Carrara, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Thomas J Rutherford, Sergio Pecorelli, Charles J Lockwood and Alessandro D Santin

    Citation: BMC Cancer 2011 11:263

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  39. Content type: Research article

    Recent advances in lung cancer biology presuppose its inflammatory origin. In this regard, LTB-4 and IL-8 are recognized to play a crucial role in neutrophil recruitment into airways during lung cancer.

    Authors: Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando and Maria P Foschino-Barbaro

    Citation: BMC Cancer 2011 11:226

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  40. Content type: Research article

    Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an important role in mediating the cyotoxicity of NK and T c...

    Authors: Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate and Richard A Prinz

    Citation: BMC Cancer 2011 11:194

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  41. Content type: Research article

    Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical...

    Authors: B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss and Zhengrong Cui

    Citation: BMC Cancer 2011 11:110

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  42. Content type: Research article

    In principle, the elimination of malignancies by oncolytic virotherapy could proceed by different mechanisms - e.g. tumor cell specific oncolysis, destruction of the tumor vasculature or an anti-tumoral immuno...

    Authors: Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola and Aladar A Szalay

    Citation: BMC Cancer 2011 11:68

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  43. Content type: Research article

    Infection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue in the aging male population in the Western world - belongs to these conditions ...

    Authors: Jan Hrbacek, Michael Urban, Eva Hamsikova, Ruth Tachezy, Vaclav Eis, Marek Brabec and Jiri Heracek

    Citation: BMC Cancer 2011 11:53

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  44. Content type: Research article

    The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy...

    Authors: Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel and Frank Berthold

    Citation: BMC Cancer 2011 11:21

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  45. Content type: Research article

    "High risk" Human Papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical integration of the HPV genome is a frequent, though not...

    Authors: Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo and Colomba Giorgi

    Citation: BMC Cancer 2011 11:17

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  46. Content type: Research article

    Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce t...

    Authors: Salomé González-Reyes, Laura Marín, Lucía González, Luis O González, José M del Casar, Maria L Lamelas, José M González-Quintana and Francisco J Vizoso

    Citation: BMC Cancer 2010 10:665

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