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BMC Cancer

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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Research article

    It is largely accepted that specific immunological parameters in solid malignancies are associated with patient’s prognosis. Recently a correlation of macrophage polarization with histomorphological parameters...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam and Manuel Weber

    Citation: BMC Cancer 2014 14:522

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  2. Content type: Research article

    Regulatory T cells (Tregs) exhibit functional abnormalities in the context of hepatocellular carcinoma (HCC). The microRNAs (miRNAs) are identified as the key modulators in Tregs. This study was to explore whe...

    Authors: Long Chen, Huiying Ma, Heng Hu, Lingling Gao, Xuan Wang, Jiaqi Ma, Qiang Gao, Binbin Liu, Guomin Zhou and Chunmin Liang

    Citation: BMC Cancer 2014 14:489

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  3. Content type: Research article

    Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.

    Authors: Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma and Chenghai Zhao

    Citation: BMC Cancer 2014 14:480

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  4. Content type: Research article

    Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical di...

    Authors: Luigi Marongiu, Anna Godi, John V Parry and Simon Beddows

    Citation: BMC Cancer 2014 14:384

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  5. Content type: Research article

    Human papillomaviruses (HPV) are the causative agents of cervical cancer in women, which results in over 250 000 deaths per year. Presently there are two prophylactic vaccines on the market, protecting against...

    Authors: Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth and Edward P Rybicki

    Citation: BMC Cancer 2014 14:367

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  6. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is assoc...

    Authors: Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan and Hassan Ashktorab

    Citation: BMC Cancer 2014 14:296

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  7. Content type: Research article

    Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adju...

    Authors: Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao and Hu Chen

    Citation: BMC Cancer 2014 14:251

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  8. Content type: Research article

    The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver.

    Authors: Siân A Pugh, Rebecca J Harrison, John N Primrose and Salim I Khakoo

    Citation: BMC Cancer 2014 14:180

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  9. Content type: Research article

    Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang

    Citation: BMC Cancer 2014 14:153

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  10. Content type: Research article

    Although the whole tumor cell vaccine can provide the best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete...

    Authors: Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei…

    Citation: BMC Cancer 2014 14:48

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  11. Content type: Research article

    Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers...

    Authors: Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja and Magnus Essand

    Citation: BMC Cancer 2014 14:30

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  12. Content type: Research article

    Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for over...

    Authors: Masanori Noguchi, Fukuko Moriya, Shigetaka Suekane, Rei Ohnishi, Satoko Matsueda, Tetsuro Sasada, Akira Yamada and Kyogo Itoh

    Citation: BMC Cancer 2013 13:613

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  13. Content type: Research article

    Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in c...

    Authors: Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour and Salem Chouaib

    Citation: BMC Cancer 2013 13:592

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  14. Content type: Research article

    We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here ...

    Authors: Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du, Yanan Zhu, Yayi Hou and Tingting Wang

    Citation: BMC Cancer 2013 13:582

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  15. Content type: Research article

    The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel

    Citation: BMC Cancer 2013 13:466

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  16. Content type: Research article

    High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...

    Authors: Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang and Qiang Ruan

    Citation: BMC Cancer 2013 13:459

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  17. Content type: Research article

    Investigating how the immune system functions during malignancies is crucial to developing novel therapeutic strategies. Natural killer (NK) cells, an important component of the innate immune system, play a vi...

    Authors: Rauf Bhat and Jean Rommelaere

    Citation: BMC Cancer 2013 13:367

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  18. Content type: Research article

    To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu

    Citation: BMC Cancer 2013 13:332

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  19. Content type: Research article

    Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette

    Citation: BMC Cancer 2013 13:324

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  20. Content type: Study protocol

    The quadrivalent human papillomavirus vaccine has been provided in Australia through the National Human Papillomavirus Vaccination Program since April 2007. National registry data demonstrates good coverage of...

    Authors: Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts and Suzanne M Garland

    Citation: BMC Cancer 2013 13:296

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