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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Research article

    Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular...

    Authors: Marcela Braga Mansur, Rocio Hassan, Thayana C Barbosa, Alessandra Splendore, Patricia Y Jotta, José Andrés Yunes, Joseph L Wiemels and Maria S Pombo-de-Oliveira

    Citation: BMC Cancer 2012 12:9

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  2. Content type: Research article

    Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we ob...

    Authors: Maria Libera Ascierto, Andrea Worschech, Zhiya Yu, Sharon Adams, Jennifer Reinboth, Nanhai G Chen, Zoltan Pos, Rahul Roychoudhuri, Giovanni Di Pasquale, Davide Bedognetti, Lorenzo Uccellini, Fabio Rossano, Paolo A Ascierto, David F Stroncek, Nicholas P Restifo, Ena Wang…

    Citation: BMC Cancer 2011 11:451

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  3. Content type: Research article

    Cervical cancer continues to be an important worldwide health problem for women. Up to 35% of patients who are diagnosed with and appropriately treated for cervical cancer will recur and treatment results are ...

    Authors: Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Michelle Glasgow, Marta Bellone, Paola Todeschini, Luisa Carrara, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Thomas J Rutherford, Sergio Pecorelli, Charles J Lockwood and Alessandro D Santin

    Citation: BMC Cancer 2011 11:263

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  4. Content type: Research article

    Recent advances in lung cancer biology presuppose its inflammatory origin. In this regard, LTB-4 and IL-8 are recognized to play a crucial role in neutrophil recruitment into airways during lung cancer.

    Authors: Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando and Maria P Foschino-Barbaro

    Citation: BMC Cancer 2011 11:226

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  5. Content type: Research article

    Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an important role in mediating the cyotoxicity of NK and T c...

    Authors: Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate and Richard A Prinz

    Citation: BMC Cancer 2011 11:194

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  6. Content type: Research article

    Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical...

    Authors: B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss and Zhengrong Cui

    Citation: BMC Cancer 2011 11:110

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  7. Content type: Research article

    In principle, the elimination of malignancies by oncolytic virotherapy could proceed by different mechanisms - e.g. tumor cell specific oncolysis, destruction of the tumor vasculature or an anti-tumoral immuno...

    Authors: Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola and Aladar A Szalay

    Citation: BMC Cancer 2011 11:68

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  8. Content type: Research article

    Infection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue in the aging male population in the Western world - belongs to these conditions ...

    Authors: Jan Hrbacek, Michael Urban, Eva Hamsikova, Ruth Tachezy, Vaclav Eis, Marek Brabec and Jiri Heracek

    Citation: BMC Cancer 2011 11:53

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  9. Content type: Research article

    The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy...

    Authors: Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel and Frank Berthold

    Citation: BMC Cancer 2011 11:21

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  10. Content type: Research article

    "High risk" Human Papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical integration of the HPV genome is a frequent, though not...

    Authors: Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo and Colomba Giorgi

    Citation: BMC Cancer 2011 11:17

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  11. Content type: Research article

    Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce t...

    Authors: Salomé González-Reyes, Laura Marín, Lucía González, Luis O González, José M del Casar, Maria L Lamelas, José M González-Quintana and Francisco J Vizoso

    Citation: BMC Cancer 2010 10:665

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  12. Content type: Research article

    Human papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal squamous-cell carcinoma (ESCC) h...

    Authors: Donghong Zhang, Qingying Zhang, Li Zhou, Leijun Huo, Yi Zhang, Zhongying Shen and Yi Zhu

    Citation: BMC Cancer 2010 10:650

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  13. Content type: Research article

    Staging of B-cell non Hodgkin's lymphoma (NHL) routinely involves bone marrow (BM) examination by trephine biopsy (BM-TB). The evidence of disease in the BM-TB results in a clinical stage IV classification aff...

    Authors: Patrizia Mancuso, Angelica Calleri, Pierluigi Antoniotti, Jessica Quarna, Giancarlo Pruneri and Francesco Bertolini

    Citation: BMC Cancer 2010 10:644

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  14. Content type: Research article

    The validation of novel prognostic indicators is of greatest interest for the management of esophageal adenocarcinoma (Barrett's cancer), particularly for non-metastasized (stage I-IIA) disease. The prognostic...

    Authors: Sandra Rauser, Rupert Langer, Sebastian Tschernitz, Peter Gais, Uta Jütting, Marcus Feith, Heinz Höfler and Axel Walch

    Citation: BMC Cancer 2010 10:608

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  15. Content type: Research article

    Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Prev...

    Authors: Michelle MS Chew, Sook-Yee Gan, Alan SB Khoo and Eng-Lai Tan

    Citation: BMC Cancer 2010 10:574

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  16. Content type: Research article

    Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and ha...

    Authors: Joris D Veltman, Margaretha EH Lambers, Menno van Nimwegen, Rudi W Hendriks, Henk C Hoogsteden, Joachim GJV Aerts and Joost PJJ Hegmans

    Citation: BMC Cancer 2010 10:464

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  17. Content type: Research article

    The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding

    Citation: BMC Cancer 2010 10:323

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