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BMC Cancer

Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Technical advance

    The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor for...

    Authors: Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl and Joachim Koch

    Citation: BMC Cancer 2015 15:351

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  2. Content type: Research article

    Up to 50% of penile squamous cell carcinomas (pSCC) develop in the context of high-risk human papillomavirus (HR-HPV) infection. Most of these tumours have been reported to show basaloid differentiation and ov...

    Authors: Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller and Konrad Steinestel

    Citation: BMC Cancer 2015 15:220

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  3. Content type: Research article

    Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and

    Authors: Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Vincent Detours

    Citation: BMC Cancer 2015 15:147

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  4. Content type: Research article

    Osteopontin (OPN) can recruit macrophages to the site of inflammation and promote tumorigenesis. M2 tumor-associated macrophages (M2-TAMs) also play an important role in cancer progression. This study aimed to...

    Authors: Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai and Yan-Shen Shan

    Citation: BMC Cancer 2015 15:128

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  5. Content type: Research article

    Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor pro...

    Authors: Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton and Elin S Mortensen

    Citation: BMC Cancer 2015 15:101

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  6. Content type: Case report

    Clear cell sarcoma (CCS), initially named malignant melanoma of soft parts, is an aggressive soft tissue sarcoma (STS) that, due to MITF activation, shares with melanoma the expression of melanocyte differenti...

    Authors: Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini and Chiara Castelli

    Citation: BMC Cancer 2015 15:58

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  7. Content type: Research article

    Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less ...

    Authors: Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll and Ike Iheanacho

    Citation: BMC Cancer 2014 14:968

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  8. Content type: Research article

    Natural killer (NK) cells play a key role in non-specific immune response in different cancers, including pancreatic cancer. However the anti-tumor effect of NK cells decreases during pancreatic cancer progres...

    Authors: Yun-Peng Peng, Jing-Jing Zhang, Wen-biao Liang, Min Tu, Zi-Peng Lu, Ji-Shu Wei, Kui-Rong Jiang, Wen-Tao Gao, Jun-Li Wu, Ze-Kuan Xu, Yi Miao and Yi Zhu

    Citation: BMC Cancer 2014 14:738

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  9. Content type: Research article

    Hepatitis B Virus (HBV) X protein (HBx) is known to be involved in the initiation and progression of hepatocellular carcinoma (HCC) through modulation of host gene response. Alterations in miRNA expressions ar...

    Authors: Manikankana Bandopadhyay, Arup Banerjee, Neelakshi Sarkar, Rajesh Panigrahi, Sibnarayan Datta, Ananya Pal, Shivram Prasad Singh, Avik Biswas, Shekhar Chakrabarti and Runu Chakravarty

    Citation: BMC Cancer 2014 14:721

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  10. Content type: Research article

    For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of...

    Authors: Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira and Emmanuel Drouet

    Citation: BMC Cancer 2014 14:665

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  11. Content type: Research article

    Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new ant...

    Authors: Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu and SaeGwang Park

    Citation: BMC Cancer 2014 14:647

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  12. Content type: Research article

    It is largely accepted that specific immunological parameters in solid malignancies are associated with patient’s prognosis. Recently a correlation of macrophage polarization with histomorphological parameters...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam and Manuel Weber

    Citation: BMC Cancer 2014 14:522

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  13. Content type: Research article

    Regulatory T cells (Tregs) exhibit functional abnormalities in the context of hepatocellular carcinoma (HCC). The microRNAs (miRNAs) are identified as the key modulators in Tregs. This study was to explore whe...

    Authors: Long Chen, Huiying Ma, Heng Hu, Lingling Gao, Xuan Wang, Jiaqi Ma, Qiang Gao, Binbin Liu, Guomin Zhou and Chunmin Liang

    Citation: BMC Cancer 2014 14:489

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  14. Content type: Research article

    Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.

    Authors: Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma and Chenghai Zhao

    Citation: BMC Cancer 2014 14:480

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  15. Content type: Research article

    Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical di...

    Authors: Luigi Marongiu, Anna Godi, John V Parry and Simon Beddows

    Citation: BMC Cancer 2014 14:384

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  16. Content type: Research article

    Human papillomaviruses (HPV) are the causative agents of cervical cancer in women, which results in over 250 000 deaths per year. Presently there are two prophylactic vaccines on the market, protecting against...

    Authors: Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth and Edward P Rybicki

    Citation: BMC Cancer 2014 14:367

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  17. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is assoc...

    Authors: Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan and Hassan Ashktorab

    Citation: BMC Cancer 2014 14:296

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  18. Content type: Research article

    Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adju...

    Authors: Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao and Hu Chen

    Citation: BMC Cancer 2014 14:251

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  19. Content type: Research article

    The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver.

    Authors: Siân A Pugh, Rebecca J Harrison, John N Primrose and Salim I Khakoo

    Citation: BMC Cancer 2014 14:180

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