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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Research article

    Tumor immune-escape has been related to the ability of cancer cells to inhibit T cell activation and dendritic cell (DC) differentiation. We previously identified a tumor initiating population, expressing the ...

    Authors: Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea and Giovanni Camussi

    Citation: BMC Cancer 2015 15:1009

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  2. Content type: Research article

    As ovarian cancer stem cells (CSCs) are responsible for tumor initiation, invasion, metastasis, and chemo-resistance, new stratagems that selectively target ovarian CSCs are critically significant. Our previou...

    Authors: Xiaofen Yao, Zhangli Dong, Qiuwan Zhang, Qian Wang and Dongmei Lai

    Citation: BMC Cancer 2015 15:956

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  3. Content type: Research article

    The objective of this work was to demonstrate that autoantibodies in breast cancer sera are not epiphenomena, and exhibit unique immunologic features resembling the rheumatic autoimmune diseases.

    Authors: Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez and Carol Peebles

    Citation: BMC Cancer 2015 15:407

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  4. Content type: Research article

    Cyclophosphamide treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms ...

    Authors: Joshua C Doloff and David J Waxman

    Citation: BMC Cancer 2015 15:375

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  5. Content type: Technical advance

    The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor for...

    Authors: Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl and Joachim Koch

    Citation: BMC Cancer 2015 15:351

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  6. Content type: Research article

    Up to 50% of penile squamous cell carcinomas (pSCC) develop in the context of high-risk human papillomavirus (HR-HPV) infection. Most of these tumours have been reported to show basaloid differentiation and ov...

    Authors: Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller and Konrad Steinestel

    Citation: BMC Cancer 2015 15:220

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  7. Content type: Research article

    Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and

    Authors: Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Vincent Detours

    Citation: BMC Cancer 2015 15:147

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  8. Content type: Research article

    Osteopontin (OPN) can recruit macrophages to the site of inflammation and promote tumorigenesis. M2 tumor-associated macrophages (M2-TAMs) also play an important role in cancer progression. This study aimed to...

    Authors: Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai and Yan-Shen Shan

    Citation: BMC Cancer 2015 15:128

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  9. Content type: Research article

    Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor pro...

    Authors: Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton and Elin S Mortensen

    Citation: BMC Cancer 2015 15:101

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  10. Content type: Case report

    Clear cell sarcoma (CCS), initially named malignant melanoma of soft parts, is an aggressive soft tissue sarcoma (STS) that, due to MITF activation, shares with melanoma the expression of melanocyte differenti...

    Authors: Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini and Chiara Castelli

    Citation: BMC Cancer 2015 15:58

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  11. Content type: Research article

    Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less ...

    Authors: Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll and Ike Iheanacho

    Citation: BMC Cancer 2014 14:968

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  12. Content type: Research article

    Natural killer (NK) cells play a key role in non-specific immune response in different cancers, including pancreatic cancer. However the anti-tumor effect of NK cells decreases during pancreatic cancer progres...

    Authors: Yun-Peng Peng, Jing-Jing Zhang, Wen-biao Liang, Min Tu, Zi-Peng Lu, Ji-Shu Wei, Kui-Rong Jiang, Wen-Tao Gao, Jun-Li Wu, Ze-Kuan Xu, Yi Miao and Yi Zhu

    Citation: BMC Cancer 2014 14:738

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  13. Content type: Research article

    Hepatitis B Virus (HBV) X protein (HBx) is known to be involved in the initiation and progression of hepatocellular carcinoma (HCC) through modulation of host gene response. Alterations in miRNA expressions ar...

    Authors: Manikankana Bandopadhyay, Arup Banerjee, Neelakshi Sarkar, Rajesh Panigrahi, Sibnarayan Datta, Ananya Pal, Shivram Prasad Singh, Avik Biswas, Shekhar Chakrabarti and Runu Chakravarty

    Citation: BMC Cancer 2014 14:721

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  14. Content type: Research article

    For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of...

    Authors: Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira and Emmanuel Drouet

    Citation: BMC Cancer 2014 14:665

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  15. Content type: Research article

    Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new ant...

    Authors: Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu and SaeGwang Park

    Citation: BMC Cancer 2014 14:647

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  16. Content type: Research article

    It is largely accepted that specific immunological parameters in solid malignancies are associated with patient’s prognosis. Recently a correlation of macrophage polarization with histomorphological parameters...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam and Manuel Weber

    Citation: BMC Cancer 2014 14:522

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  17. Content type: Research article

    Regulatory T cells (Tregs) exhibit functional abnormalities in the context of hepatocellular carcinoma (HCC). The microRNAs (miRNAs) are identified as the key modulators in Tregs. This study was to explore whe...

    Authors: Long Chen, Huiying Ma, Heng Hu, Lingling Gao, Xuan Wang, Jiaqi Ma, Qiang Gao, Binbin Liu, Guomin Zhou and Chunmin Liang

    Citation: BMC Cancer 2014 14:489

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  18. Content type: Research article

    Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.

    Authors: Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma and Chenghai Zhao

    Citation: BMC Cancer 2014 14:480

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  19. Content type: Research article

    Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical di...

    Authors: Luigi Marongiu, Anna Godi, John V Parry and Simon Beddows

    Citation: BMC Cancer 2014 14:384

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  20. Content type: Research article

    Human papillomaviruses (HPV) are the causative agents of cervical cancer in women, which results in over 250 000 deaths per year. Presently there are two prophylactic vaccines on the market, protecting against...

    Authors: Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth and Edward P Rybicki

    Citation: BMC Cancer 2014 14:367

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  21. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is assoc...

    Authors: Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan and Hassan Ashktorab

    Citation: BMC Cancer 2014 14:296

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  22. Content type: Research article

    Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adju...

    Authors: Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao and Hu Chen

    Citation: BMC Cancer 2014 14:251

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  23. Content type: Research article

    The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver.

    Authors: Siân A Pugh, Rebecca J Harrison, John N Primrose and Salim I Khakoo

    Citation: BMC Cancer 2014 14:180

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  24. Content type: Research article

    Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang

    Citation: BMC Cancer 2014 14:153

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  25. Content type: Research article

    Although the whole tumor cell vaccine can provide the best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete...

    Authors: Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei…

    Citation: BMC Cancer 2014 14:48

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  26. Content type: Research article

    Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers...

    Authors: Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja and Magnus Essand

    Citation: BMC Cancer 2014 14:30

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  27. Content type: Research article

    Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for over...

    Authors: Masanori Noguchi, Fukuko Moriya, Shigetaka Suekane, Rei Ohnishi, Satoko Matsueda, Tetsuro Sasada, Akira Yamada and Kyogo Itoh

    Citation: BMC Cancer 2013 13:613

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  28. Content type: Research article

    Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in c...

    Authors: Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour and Salem Chouaib

    Citation: BMC Cancer 2013 13:592

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  29. Content type: Research article

    We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here ...

    Authors: Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du, Yanan Zhu, Yayi Hou and Tingting Wang

    Citation: BMC Cancer 2013 13:582

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  30. Content type: Research article

    The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel

    Citation: BMC Cancer 2013 13:466

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  31. Content type: Research article

    High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...

    Authors: Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang and Qiang Ruan

    Citation: BMC Cancer 2013 13:459

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  32. Content type: Research article

    Investigating how the immune system functions during malignancies is crucial to developing novel therapeutic strategies. Natural killer (NK) cells, an important component of the innate immune system, play a vi...

    Authors: Rauf Bhat and Jean Rommelaere

    Citation: BMC Cancer 2013 13:367

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  33. Content type: Research article

    To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu

    Citation: BMC Cancer 2013 13:332

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  34. Content type: Research article

    Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette

    Citation: BMC Cancer 2013 13:324

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  35. Content type: Study protocol

    The quadrivalent human papillomavirus vaccine has been provided in Australia through the National Human Papillomavirus Vaccination Program since April 2007. National registry data demonstrates good coverage of...

    Authors: Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts and Suzanne M Garland

    Citation: BMC Cancer 2013 13:296

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  36. Content type: Research article

    It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly ...

    Authors: Sonia Cellot, Donna Johnston, David Dix, Marie-Chantal Ethier, Biljana Gillmeister, David Mitchell, Rochelle Yanofsky, Victor Lewis, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Lynette Bowes, Bruno Michon, Kent Stobart, Josee Brossard…

    Citation: BMC Cancer 2013 13:276

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  37. Content type: Research article

    Our previous studies have suggested that the primary impact of immune cell infiltration into the normal or pre-invasive tissue component is associated with the physical destruction of epithelial capsules, whic...

    Authors: Hongyan Yuan, Yi-Hsuan Hsiao, Yiyu Zhang, Jinlian Wang, Chao Yin, Rong Shen and Yiping Su

    Citation: BMC Cancer 2013 13:258

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  38. Content type: Research article

    Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating fac...

    Authors: Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev and Axel Ullrich

    Citation: BMC Cancer 2013 13:197

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  39. Content type: Research article

    Several human cancers are known to be associated with inflammation and/or viral infections. However, the influence of tumour-related inflammation on viral uptake is largely unknown. In this study we used oesop...

    Authors: Georgia Schäfer, Siti Kabanda, Beverly van Rooyen, Martina Bergant Marušič, Lawrence Banks and M Iqbal Parker

    Citation: BMC Cancer 2013 13:185

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  40. Content type: Research article

    High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a n...

    Authors: Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi and Yoko Nakasu

    Citation: BMC Cancer 2012 12:623

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  41. Content type: Study protocol

    Asbestos is the main cause of MPM in industrialized countries. Even since asbestos is banned in most developed countries, the peak wave of MPM incidence is anticipated for the next years due to the long latenc...

    Authors: Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder and Christoph Renner

    Citation: BMC Cancer 2012 12:615

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  42. Content type: Research article

    Identification of new cancer antigens is necessary for the efficient diagnosis and immunotherapy. A variety of tumor antigens have been identified by several methodologies. Among those antigens, cancer/testis ...

    Authors: Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama and Toshiro Ono

    Citation: BMC Cancer 2012 12:520

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  43. Content type: Research article

    One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of...

    Authors: Ceyhan Ceran, Murat Cokol, Sultan Cingoz, Ipek Tasan, Mehmet Ozturk and Tamer Yagci

    Citation: BMC Cancer 2012 12:450

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  44. Content type: Research article

    Hepatoblastoma (HB) is the most common primary, malignant pediatric liver tumor in children. The treatment results for affected children have markedly improved in recent decades. However, the prognosis for hig...

    Authors: Shu-Cheng Zhang, Wei-Lin Wang, Wei-Song Cai, Kai-Lei Jiang and Zheng-Wei Yuan

    Citation: BMC Cancer 2012 12:427

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  45. Content type: Research article

    The role of Th17 cells in colorectal tumorigenesis and development still remains unclear, despite the fact that it has been established in the pathogenesis of autoimmune diseases.

    Authors: Jiansheng Wang, Kaiyu Xu, Jing Wu, Chenghua Luo, Yuchen Li, Xuebin Wu, Hong Gao, Guosheng Feng and Bao-Zhu Yuan

    Citation: BMC Cancer 2012 12:418

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  46. Content type: Research article

    Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase act...

    Authors: Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna and Martin Ruthardt

    Citation: BMC Cancer 2012 12:411

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  47. Content type: Research article

    Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors h...

    Authors: Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui and Han-Fei Ding

    Citation: BMC Cancer 2012 12:203

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  48. Content type: Research article

    WNT7a, a member of the Wnt ligand family implicated in several developmental processes, has also been reported to be dysregulated in some types of tumors; however, its function and implication in oncogenesis i...

    Authors: Alejandra B Ochoa-Hernández, Moisés Ramos-Solano, Ivan D Meza-Canales, Beatriz García-Castro, Mónica A Rosales-Reynoso, Judith A Rosales-Aviña, Esperanza Barrera-Chairez, Pablo C Ortíz-Lazareno, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Patricio Barros-Núñez and Adriana Aguilar-Lemarroy

    Citation: BMC Cancer 2012 12:60

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