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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmenta...

    Authors: Xin Xu, Zhiqiang Liu, Weimin Xiong, Minglian Qiu, Shuling Kang, Qiuping Xu, Lin Cai and Fei He

    Citation: BMC Cancer 2020 20:903

    Content type: Research article

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  2. The association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR a...

    Authors: Yiyang Wang, Xiaofei Dong, Zhaokui Qu, Kang Peng, Xiaolei Sun and Renfu Chen

    Citation: BMC Cancer 2020 20:900

    Content type: Research article

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  3. Sintilimab blocks the interaction between programmed death-1 (PD-1) and its ligands. The safety and efficacy of sintilimab combined with oxaliplatin/capecitabine (CapeOx) as first-line treatment were evaluated...

    Authors: Haiping Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao, Xin Xu, Ning Li, Cheng Xiao, Huan Wang, Lisong Teng, Hui Zhou, Shuyan Wang, Donglei Zhu, Bo Peng, Lin Shen and Nong Xu

    Citation: BMC Cancer 2020 20:760

    Content type: Research article

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  4. Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness. As a randomized con...

    Authors: Melanie Lindenberg, Valesca Retèl, Maartje Rohaan, Joost van den Berg, John Haanen and Wim van Harten

    Citation: BMC Cancer 2020 20:712

    Content type: Research article

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  5. The identification of pathologically altered neutrophil granulocyte migration patterns bears strong potential for surveillance and prognostic scoring of diseases. We recently identified a strong correlation be...

    Authors: Lea Bornemann, Marc Schuster, Saskia Schmitz, Charlyn Sobczak, Clara Bessen, Simon F. Merz, Karl-Heinz Jöckel, Thomas Haverkamp, Matthias Gunzer and Joachim R. Göthert

    Citation: BMC Cancer 2020 20:650

    Content type: Research article

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  6. Despite recent advances in cancer immunotherapy, the efficacy of these therapies for the treatment of human prostate cancer patients is low due to the complex immune evasion mechanisms (IEMs) of prostate cance...

    Authors: Mayassa J. Bou-Dargham, Linlin Sha, Qing-Xiang Amy Sang and Jinfeng Zhang

    Citation: BMC Cancer 2020 20:572

    Content type: Research article

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  7. Glioma is the most common primary brain tumor, occurring due to the carcinogenesis of glial cells in the brain and spinal cord. Many aspects of the mechanism of its tumorigenesis remain unknown. The relationsh...

    Authors: Zehao Cai, Shoubo Yang, Xiaoyan Li, Feng Chen and Wenbin Li

    Citation: BMC Cancer 2020 20:549

    Content type: Research article

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  8. Cervical cancer is caused by Human Papilloma viruses (HPV) and is preceded by precursor stages: Cervical Intraepithelial Neoplasia (CIN). CIN is mostly found in women in their reproductive age and treated with...

    Authors: R. L. O. van de Laar, W. Hofhuis, R. G. Duijnhoven, S. Polinder, W. J. G. Melchers, F. J. van Kemenade, R. L. M. Bekkers and H. J. Van Beekhuizen

    Citation: BMC Cancer 2020 20:539

    Content type: Study protocol

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  9. Numerous studies conducted over the past 30 years have pointed to the presence of Epstein–Barr virus (EBV) in gastric cancer samples. This study was aimed to provide a meta-analytic review of the prevalence of...

    Authors: Ahmad Tavakoli, Seyed Hamidreza Monavari, Farid Solaymani Mohammadi, Seyed Jalal Kiani, Saber Armat and Mohammad Farahmand

    Citation: BMC Cancer 2020 20:493

    Content type: Research article

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  10. While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun testing in patients with breast cancer (BC), the effects of chemotherapy on ICP expression in circulating...

    Authors: Robert Wesolowski, Andrew Stiff, Dionisia Quiroga, Christopher McQuinn, Zaibo Li, Hiroaki Nitta, Himanshu Savardekar, Brooke Benner, Bhuvaneswari Ramaswamy, Maryam Lustberg, Rachel M. Layman, Erin Macrae, Mahmoud Kassem, Nicole Williams, Sagar Sardesai, Jeffrey VanDeusen…

    Citation: BMC Cancer 2020 20:445

    Content type: Research article

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  11. Colon cancer is one of the most common malignancies and the fourth leading cause of cancer-related mortality in the world. Colibactin, which is synthesized by the pks genomic island of E. coli interfere with the ...

    Authors: Faezah Kosari, Mohammad Taheri, Abbas Moradi, Reza Hakimi Alni and Mohammad Yousef Alikhani

    Citation: BMC Cancer 2020 20:267

    Content type: Research article

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  12. Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma (OCSCC), has not been well studied.

    Authors: Ying Xiong, David M. Neskey, Joshua D. Horton, Chrystal M. Paulos, Hannah M. Knochelmann, Kent E. Armeson and M. Rita I. Young

    Citation: BMC Cancer 2020 20:229

    Content type: Research article

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  13. Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate the function of T cells. Although recent studies indicate that PD-1 is also expressed on other immune cells bes...

    Authors: Yusuke Kono, Hiroaki Saito, Wataru Miyauchi, Shota Shimizu, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Yuji Nakayama, Chiye Sakurai, Kiyotaka Hatsuzawa and Yoshiyuki Fujiwara

    Citation: BMC Cancer 2020 20:175

    Content type: Research article

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  14. Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and p...

    Authors: Yutuan Wu, Shuang Ye, Shyamal Goswami, Xuan Pei, Libing Xiang, Xiaoming Zhang and Huijuan Yang

    Citation: BMC Cancer 2020 20:173

    Content type: Research article

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  15. Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. Direct comparison among IL-36α, IL-36β and IL-36γ in the prognosis of CRC is unclear.

    Authors: Feier Chen, Meng Qu, Feng Zhang, Zhenyu Tan, Qinghua Xia, Brett D. Hambly, Shisan Bao and Kun Tao

    Citation: BMC Cancer 2020 20:92

    Content type: Research article

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  16. There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, are focused on. Though many types of immune checkpoint inhibitors are there, the differenc...

    Authors: Kazushige Yoshida, Masanori Okamoto, Jun Sasaki, Chika Kuroda, Haruka Ishida, Katsuya Ueda, Hirokazu Ideta, Takayuki Kamanaka, Atsushi Sobajima, Takashi Takizawa, Manabu Tanaka, Kaoru Aoki, Takeshi Uemura, Hiroyuki Kato, Hisao Haniu and Naoto Saito

    Citation: BMC Cancer 2020 20:25

    Content type: Research article

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  17. Patients with lymphoma are at risk for developing pulmonary opportunistic infections due to immunocompromise. However, clinical reports of concurrent lymphoma and opportunistic infection at presentation are ra...

    Authors: Lianyou Shao, Longxiang Jiang, Siyao Wu, Lihua Yu, Liangxing Wang and Xiaoying Huang

    Citation: BMC Cancer 2020 20:15

    Content type: Case report

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  18. Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is ...

    Authors: Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi and Peter Siesjö

    Citation: BMC Cancer 2020 20:7

    Content type: Research article

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  19. Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th...

    Authors: Faqing Tian, Bo Lu, Ziren Chen, Junru Liu, Delan Ji, Juheng Li, Meiqin Tang, Wei Zhu and Juan Li

    Citation: BMC Cancer 2019 19:1246

    Content type: Research article

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  20. Immune checkpoint inhibitors (ICIs) have achieved unprecedented success in cancer treatment over the past decade. The application of ICIs hasled to the discovery of various types of immune-related adverse even...

    Authors: Yuan Liu, Zhi Liu, Xuejun Zeng, Chunmei Bai, Lin Chen, Songbai Lin and Xinlun Tian

    Citation: BMC Cancer 2019 19:1193

    Content type: Case report

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  21. In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to high-grade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy ...

    Authors: Chihab Klose, Susanne Berchtold, Marina Schmidt, Julia Beil, Irina Smirnow, Sascha Venturelli, Markus Burkard, Rupert Handgretinger and Ulrich M. Lauer

    Citation: BMC Cancer 2019 19:1172

    Content type: Research article

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  22. This study aimed to assess the effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing treatment with immune checkpoint inhibitors (ICIs).

    Authors: Hyunho Kim, Ji Eun Lee, Sook Hee Hong, Myung Ah. Lee, Jin Hyoung Kang and In-Ho Kim

    Citation: BMC Cancer 2019 19:1100

    Content type: Research article

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  23. NY-BR-1 has been described as a breast cancer associated differentiation antigen with intrinsic immunogenicity giving rise to endogenous T and B cell responses. The current study presents the first murine tumo...

    Authors: Krishna Das, David Eisel, Mathias Vormehr, Karin Müller-Decker, Adriane Hommertgen, Dirk Jäger, Inka Zörnig, Markus Feuerer, Annette Kopp-Schneider, Wolfram Osen and Stefan B. Eichmüller

    Citation: BMC Cancer 2019 19:914

    Content type: Research article

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  24. Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES re...

    Authors: Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki and John E. Shively

    Citation: BMC Cancer 2019 19:882

    Content type: Technical advance

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  25. Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma...

    Authors: Yuan Cheng, Yinan Xiao, Ruofan Zhou, Yi Liao, Jing Zhou and Xuelei Ma

    Citation: BMC Cancer 2019 19:842

    Content type: Research article

    Published on:

  26. To develop a new 18 high-risk human papillomavirus (HR HPV) detection and genotyping assay, which is important to evaluate the risk degree of HR HPV for causing cancers.

    Authors: Xushan Cai, Qinghua Guan, Yu Huan, Ziyu Liu, Jiehua Qi and Shichao Ge

    Citation: BMC Cancer 2019 19:825

    Content type: Research article

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  27. Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However...

    Authors: Seyedeh Raheleh Niavarani, Christine Lawson, Orneala Bakos, Marie Boudaud, Cory Batenchuk, Samuel Rouleau and Lee-Hwa Tai

    Citation: BMC Cancer 2019 19:823

    Content type: Research article

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  28. There is currently no evidence that hepatitis C virus (HCV) genotype affects survival in patients with hepatocellular carcinoma (HCC). This study aimed to investigate whether the HCV genotype affected the surv...

    Authors: Hye Kyong Park, Sang Soo Lee, Chang Bin Im, Changjo Im, Ra Ri Cha, Wan Soo Kim, Hyun Chin Cho, Jae Min Lee, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

    Citation: BMC Cancer 2019 19:822

    Content type: Research article

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  29. Acquired immunodeficiency associated with thymoma is a rare disorder. Here we reported a case of acquired immunodeficiency with thymoma, with an unusual pattern of low CD4+ count with normal gammaglobulin levels.

    Authors: Takahisa Kawamura, Tateaki Naito, Haruki Kobayashi, Kazuhisa Nakashima, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo and Toshiaki Takahashi

    Citation: BMC Cancer 2019 19:762

    Content type: Case report

    Published on:

  30. Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are poorly understood and chemotherapeutic strategies to cure liver cancer are not available. A...

    Authors: Joseph Torresi, Bang Manh Tran, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab and Elizabeth Vincan

    Citation: BMC Cancer 2019 19:707

    Content type: Review

    Published on:

  31. Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating di...

    Authors: Zhi Ji, Zhi Peng, Jifang Gong, Xiaotian Zhang, Jian Li, Ming Lu, Zhihao Lu and Lin Shen

    Citation: BMC Cancer 2019 19:705

    Content type: Research article

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  32. In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical ou...

    Authors: Beatrix Bencsikova, Eva Budinska, Iveta Selingerova, Katerina Pilatova, Lenka Fedorova, Kristina Greplova, Rudolf Nenutil, Dalibor Valik, Radka Obermannova, Michael A. Sheard and Lenka Zdrazilova-Dubska

    Citation: BMC Cancer 2019 19:687

    Content type: Research article

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  33. Nasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a role in...

    Authors: Miia Ruuskanen, Ilmo Leivo, Heikki Minn, Tero Vahlberg, Caj Haglund, Jaana Hagström and Heikki Irjala

    Citation: BMC Cancer 2019 19:624

    Content type: Research article

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  34. A higher density of tumor-infiltrating lymphocytes (TILs) can lead to greater therapeutic effects and improved prognoses in cancer treatment. Similar results have been observed in breast cancer, particularly i...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2019 19:615

    Content type: Research article

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  35. Programmed cell death protein-1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have remarkable clinical efficacy in the treatment of non-small cell lung cancer (NSCLC); however, the breakdown of ...

    Authors: Xiaoying Sun, Raheleh Roudi, Ting Dai, Shangya Chen, Bin Fan, Hongjin Li, Yaqiong Zhou, Min Zhou, Bo Zhu, Chengqian Yin, Bin Li and Xin Li

    Citation: BMC Cancer 2019 19:558

    Content type: Research article

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  36. Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cy...

    Authors: Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte and Scott H. Robbins

    Citation: BMC Cancer 2019 19:540

    Content type: Research article

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  37. Avelumab is an anti-programmed cell death ligand 1 (PD-L1) antibody approved for treatment of Merkel cell carcinoma (MCC) and locally advanced or metastatic urothelial carcinoma. It shares a similar side effec...

    Authors: Michael A. Cardis, Hong Jiang, Julius Strauss, James L. Gulley and Isaac Brownell

    Citation: BMC Cancer 2019 19:539

    Content type: Case report

    Published on:

  38. Metastases account for 90% of all cancer-related deaths, becoming a therapeutic problem. Approximately 50% of all uveal melanoma (UM) patients will develop metastases, mainly in the liver. Post-mortem analyses of...

    Authors: Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado and Hans E. Grossniklaus

    Citation: BMC Cancer 2019 19:484

    Content type: Research article

    Published on:

  39. Autoantibodies function as markers of tumorigenesis and have been proposed to enhance early detection of malignancies. We recently reported, using immunoscreening of a T7 complementary DNA (cDNA) library of br...

    Authors: Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman and Félix Fernández-Madrid

    Citation: BMC Cancer 2019 19:411

    Content type: Research article

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  40. A causal association has been suggested between certain bacteria and colorectal cancer (CRC). Only a few studies have, however, investigated the presence of these bacteria directly in colon tissue with conflic...

    Authors: Caspar Bundgaard-Nielsen, Ulrik T. Baandrup, Lars P. Nielsen and Suzette Sørensen

    Citation: BMC Cancer 2019 19:399

    Content type: Research article

    Published on:

  41. Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first ...

    Authors: Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park and Youngil Koh

    Citation: BMC Cancer 2019 19:358

    Content type: Research article

    Published on:

  42. Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and...

    Authors: Juraimi Raihan, Umar Ahmad, Yoke Keong Yong, Zolkapli Eshak, Fauziah Othman and Aini Ideris

    Citation: BMC Cancer 2019 19:315

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2019 19:378

  43. The clinical and experimental evidences for complement-cancer relationships are solid, whereas an epidemiological study reporting the imbalance of complement system in patients is still lacking.

    Authors: Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou and Muying Ying

    Citation: BMC Cancer 2019 19:201

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:269