Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Debate

    Infections and cancer: the “fifty shades of immunity” hypothesis

    Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have als...

    Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas and Benjamin Roche

    BMC Cancer 2017 17:257

    Published on: 12 April 2017

  2. Research article

    A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen

    Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti...

    Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte and William Raoul

    BMC Cancer 2017 17:220

    Published on: 27 March 2017

  3. Research article

    Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer

    Gastric cancer is one of the most common and lethal type of cancer worldwide. Infection with Helicobacter pylori (H. pylori) is recognized as the major cause of gastric cancer. However, it remains unclear the mec...

    Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran and Marygorret Obonyo

    BMC Cancer 2017 17:133

    Published on: 15 February 2017

  4. Research article

    Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

    Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy

    BMC Cancer 2017 17:104

    Published on: 6 February 2017

  5. Research article

    Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model

    Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to ...

    Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký and Jan Ženka

    BMC Cancer 2016 16:940

    Published on: 7 December 2016

  6. Research article

    Prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with HIV in Denmark – the SHADE

    Women living with HIV (WLWH) are at increased risk of persistent human papillomavirus (HPV) infection, cervical dysplasia and cervical cancer compared with women from the general population (WGP). We assessed ...

    Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde and Anne-Mette Lebech

    BMC Cancer 2016 16:866

    Published on: 8 November 2016

  7. Research article

    Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

    For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruz...

    Paula Abello-Cáceres, Javier Pizarro-Bauerle, Carlos Rosas, Ismael Maldonado, Lorena Aguilar-Guzmán, Carlos González, Galia Ramírez, Jorge Ferreira and Arturo Ferreira

    BMC Cancer 2016 16:731

    Published on: 13 September 2016

  8. Research article

    MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity

    Cancer of the ovary is mostly discovered at a late stage and cannot be removed by surgery alone. Therefore surgery is usually followed by adjuvant chemotherapy. However, few reliable biomarkers exist to predic...

    Raoul A. Droeser, Robert Mechera, Silvio Däster, Benjamin Weixler, Marko Kraljević, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano and Gad Singer

    BMC Cancer 2016 16:639

    Published on: 17 August 2016

  9. Research article

    CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

    The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcri...

    Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman and Carlo Castoro

    BMC Cancer 2016 16:388

    Published on: 4 July 2016

  10. Research article

    Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

    Human papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p5...

    Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff and Peter K. C. Goon

    BMC Cancer 2016 16:367

    Published on: 13 June 2016

  11. Research article

    Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

    Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the...

    Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman and Adrienne C. Scheck

    BMC Cancer 2016 16:310

    Published on: 13 May 2016

  12. Research article

    A novel anti-p21Ras scFv antibody reacting specifically with human tumour cell lines and primary tumour tissues

    The ras genes play an important role in the development and progression of human tumours. Neutralizing Ras proteins in the cytoplasm could be an effective approach to blocking ras signalling. In this study, we pr...

    Ju-Lun Yang, Du-Xian Liu, Shi-Jian Zhen, Yun-Gang Zhou, Dai-Jun Zhang, Li-Ying Yang, Hao-Bing Chen and Qiang Feng

    BMC Cancer 2016 16:131

    Published on: 20 February 2016

  13. Research article

    Role of HLA-G and extracellular vesicles in renal cancer stem cell-induced inhibition of dendritic cell differentiation

    Tumor immune-escape has been related to the ability of cancer cells to inhibit T cell activation and dendritic cell (DC) differentiation. We previously identified a tumor initiating population, expressing the ...

    Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea and Giovanni Camussi

    BMC Cancer 2015 15:1009

    Published on: 24 December 2015

  14. Research article

    Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

    The objective of this work was to demonstrate that autoantibodies in breast cancer sera are not epiphenomena, and exhibit unique immunologic features resembling the rheumatic autoimmune diseases.

    Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez and Carol Peebles

    BMC Cancer 2015 15:407

    Published on: 15 May 2015

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