Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Research article

    Combination of Helicobacter pylori infection and the interleukin 8 –251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer

    Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori. We aimed to investi...

    Young Woon Chang, Chi Hyuk Oh, Jung-Wook Kim, Jae Won Lee, Mi Ju Park, Jae-Jun Shim, Chang Kyun Lee, Jae-Young Jang, Seok Ho Dong, Hyo Jong Kim, Sung Soo Kim and Byung-Ho Kim

    BMC Cancer 2017 17:388

    Published on: 30 May 2017

  2. Research article

    Circulating blood levels of IL-6, IFN-γ, and IL-10 as potential diagnostic biomarkers in gastric cancer: a controlled study

    Gastric adenocarcinoma is the third most common cause of cancer-associated death worldwide. Helicobacter pylori infection activates a signaling cascade that induces production of cytokines and chemokines involved...

    Norma Sánchez-Zauco, J. Torres, Alejandro Gómez, Margarita Camorlinga-Ponce, Leopoldo Muñoz-Pérez, Ramón Herrera-Goepfert, Rafael Medrano-Guzmán, Silvia Giono-Cerezo and Carmen Maldonado-Bernal

    BMC Cancer 2017 17:384

    Published on: 30 May 2017

  3. Research article

    Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

    Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this stud...

    Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero and Jose Ponce-Lorenzo

    BMC Cancer 2017 17:320

    Published on: 8 May 2017

  4. Debate

    Infections and cancer: the “fifty shades of immunity” hypothesis

    Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have als...

    Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas and Benjamin Roche

    BMC Cancer 2017 17:257

    Published on: 12 April 2017

  5. Research article

    A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen

    Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti...

    Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte and William Raoul

    BMC Cancer 2017 17:220

    Published on: 27 March 2017

  6. Research article

    Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer

    Gastric cancer is one of the most common and lethal type of cancer worldwide. Infection with Helicobacter pylori (H. pylori) is recognized as the major cause of gastric cancer. However, it remains unclear the mec...

    Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran and Marygorret Obonyo

    BMC Cancer 2017 17:133

    Published on: 15 February 2017

  7. Research article

    Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

    Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy

    BMC Cancer 2017 17:104

    Published on: 6 February 2017

  8. Research article

    Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model

    Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to ...

    Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký and Jan Ženka

    BMC Cancer 2016 16:940

    Published on: 7 December 2016

  9. Research article

    Prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with HIV in Denmark – the SHADE

    Women living with HIV (WLWH) are at increased risk of persistent human papillomavirus (HPV) infection, cervical dysplasia and cervical cancer compared with women from the general population (WGP). We assessed ...

    Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde and Anne-Mette Lebech

    BMC Cancer 2016 16:866

    Published on: 8 November 2016

  10. Research article

    Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

    For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruz...

    Paula Abello-Cáceres, Javier Pizarro-Bauerle, Carlos Rosas, Ismael Maldonado, Lorena Aguilar-Guzmán, Carlos González, Galia Ramírez, Jorge Ferreira and Arturo Ferreira

    BMC Cancer 2016 16:731

    Published on: 13 September 2016

  11. Research article

    MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity

    Cancer of the ovary is mostly discovered at a late stage and cannot be removed by surgery alone. Therefore surgery is usually followed by adjuvant chemotherapy. However, few reliable biomarkers exist to predic...

    Raoul A. Droeser, Robert Mechera, Silvio Däster, Benjamin Weixler, Marko Kraljević, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano and Gad Singer

    BMC Cancer 2016 16:639

    Published on: 17 August 2016

  12. Research article

    CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

    The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcri...

    Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman and Carlo Castoro

    BMC Cancer 2016 16:388

    Published on: 4 July 2016

  13. Research article

    Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

    Human papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p5...

    Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff and Peter K. C. Goon

    BMC Cancer 2016 16:367

    Published on: 13 June 2016

  14. Research article

    Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

    Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the...

    Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman and Adrienne C. Scheck

    BMC Cancer 2016 16:310

    Published on: 13 May 2016

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