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Infection, immunity and cancer vaccines

Section edited by Christophe Nicot

This section focuses on all aspects of infectious agents associated with cancer and tumor immunology. Topics of interest include, but are not limited to, tumor immunity, immunotherapy, cancer vaccines, viral carcinogenesis and virus-host interactions.

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  1. Content type: Study protocol

    Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such...

    Authors: Nikolas von Bubnoff, Gabriele Ihorst, Olga Grishina, Nadine Röthling, Hartmut Bertz, Justus Duyster, Jürgen Finke and Robert Zeiser

    Citation: BMC Cancer 2018 18:1132

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  2. Content type: Case report

    Intravascular lymphoma is a rare type of non-Hodgkin lymphoma mostly of B-cell lineage. A few cases of intravascular lymphoma have been found to be of NK/T-cell origin, mainly affecting the skin and central ne...

    Authors: Magda Zanelli, Maria Cecilia Mengoli, Rachele Del Sordo, Angelo Cagini, Loredana De Marco, Edoardo Simonetti, Giovanni Martino, Maurizio Zizzo and Stefano Ascani

    Citation: BMC Cancer 2018 18:1115

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  3. Content type: Review

    Recent breakthroughs in targeted therapy and immunotherapy have revolutionized the treatment of lung cancer, the leading cause of cancer-related deaths in the United States and worldwide. Here we provide an ov...

    Authors: Xingxiang Pu, Lin Wu, Dan Su, Weimin Mao and Bingliang Fang

    Citation: BMC Cancer 2018 18:1082

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  4. Content type: Research article

    Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims of this study were to investigate the immune landscape of neuroblastoma and to evaluate the in vivo ...

    Authors: Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli and Roberto Luksch

    Citation: BMC Cancer 2018 18:983

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  5. Content type: Research article

    Carcinogenesis and tumor growth are associated with chronic inflammation and the host immune system. Here, we investigated the clinical significance and relationship between tumor-infiltrating lymphocytes (TIL...

    Authors: Kwan Ho Lee, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Sung-Im Do, Seoung Wan Chae and Chan Heun Park

    Citation: BMC Cancer 2018 18:938

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  6. Content type: Research article

    Chimeric antigen receptor T (CAR T) cells immunotherapy is rapidly developed in treating cancers, especially relapsed or refractory B-cell malignancies.

    Authors: Hui Zhou, Yuling Luo, Sha Zhu, Xi Wang, Yunuo Zhao, Xuejin Ou, Tao Zhang and Xuelei Ma

    Citation: BMC Cancer 2018 18:929

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  7. Content type: Research article

    The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular...

    Authors: Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal and Herbert J. Zeh III

    Citation: BMC Cancer 2018 18:678

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  8. Content type: Research article

    RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA that has been indicated as a key regulator in the development of myeloid cells by targeting runt-related transcription factor 1 (RUNX1). Myeloid-derived ...

    Authors: Xinyu Tian, Jie Ma, Ting Wang, Jie Tian, Yu Zheng, Rongrong Peng, Yungang Wang, Yue Zhang, Lingxiang Mao, Huaxi Xu and Shengjun Wang

    Citation: BMC Cancer 2018 18:660

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  9. Content type: Case report

    Immune checkpoint inhibitors are standard treatments for non-small cell lung cancer. Unique cases with paradoxical acceleration of the disease after immunotherapy have been reported. These have been described ...

    Authors: Taro Shinozaki, Eri Iwami, Shinnosuke Ikemura, Tatsu Matsuzaki, Takahiro Nakajima, Kazuhiko Hashimoto and Takeshi Terashima

    Citation: BMC Cancer 2018 18:620

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  10. Content type: Research article

    Prognosis of pancreatic cancer is poor with a 5-year survival rate of only 7%. Although several new chemotherapy treatments have shown promising results, all patients will eventually progress, and we need to d...

    Authors: Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Itzel B. Villalobos, Yoshinori Naoe, Toru Ichinose, Nobuto Koyama, Maki Tanaka, Yasuhiro Kodera and Hidemi Goto

    Citation: BMC Cancer 2018 18:596

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  11. Content type: Debate

    Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at ‘hiding’ than others. With an increased understanding of tumor immune surveillance, immu...

    Authors: Joshua P. Bates, Roshanak Derakhshandeh, Laundette Jones and Tonya J. Webb

    Citation: BMC Cancer 2018 18:556

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  12. Content type: Research article

    All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year. ...

    Authors: Hillary Mabeya, Sonia Menon, Steven Weyers, Violet Naanyu, Emily Mwaliko, Elijah Kirop, Omenge Orango, Heleen Vermandere and Davy Vanden Broeck

    Citation: BMC Cancer 2018 18:557

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  13. Content type: Research article

    The prognostic effect of elevated systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), remains controversial in cancer patients. This meta-analysis wa...

    Authors: Ying Zhu, Sanqin Zhou, Yang Liu, Lingyun Zhai and Xiwen Sun

    Citation: BMC Cancer 2018 18:443

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  14. Content type: Technical advance

    Tumor neoantigens are drivers of cancer immunotherapy response; however, current prediction tools produce many candidates requiring further prioritization. Additional filtration criteria and population-level u...

    Authors: Mary A. Wood, Mayur Paralkar, Mihir P. Paralkar, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Adam Margolin, Abhinav Nellore and Reid F. Thompson

    Citation: BMC Cancer 2018 18:414

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  15. Content type: Research article

    We conducted a phase I/Ib, open-label, single-arm trial to assess the safety, tolerability and optimal scheduling regimen of OTSGC-A24 cancer vaccine in patients with advanced gastric cancer.

    Authors: Raghav Sundar, Sun Young Rha, Hiroki Yamaue, Masahiro Katsuda, Koji Kono, Hyo Song Kim, Chan Kim, Kousaku Mimura, Ley-Fang Kua and Wei Peng Yong

    Citation: BMC Cancer 2018 18:332

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  16. Content type: Research article

    Innate lymphoid cells (ILC) are part of a heterogeneous family of haematopoietic effector cells which lack re-arranged antigen-specific receptors. They promote host defense and contribute to tissue and metabol...

    Authors: Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong and Graham Ogg

    Citation: BMC Cancer 2018 18:341

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  17. Content type: Research article

    The prevalence of high-risk human papillomavirus (HPV) DNA in cases of oral cavity squamous cell carcinoma (SCC) varies widely. The aim of this study is to investigate the frequency of high-risk HPV DNA in a l...

    Authors: Priscila Marinho de Abreu, Anna Clara Gregório Có, Pedro Leite Azevedo, Isabella Bittencourt do Valle, Karine Gadioli de Oliveira, Sônia Alves Gouvea, Melissa Freitas Cordeiro-Silva, Iúri Drummond Louro, José Roberto Vasconcelos de Podestá, Jeferson Lenzi, Agenor Sena, Elismauro Francisco Mendonça and Sandra Lúcia Ventorin von Zeidler

    Citation: BMC Cancer 2018 18:324

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  18. Content type: Research article

    Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only eff...

    Authors: Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe and Flavio Salazar-Onfray

    Citation: BMC Cancer 2018 18:243

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  19. Content type: Study protocol

    There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicat...

    Authors: Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu and Larry W. Kwak

    Citation: BMC Cancer 2018 18:187

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  20. Content type: Research article

    Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in...

    Authors: Reem Al Dossary, Khaled R. Alkharsah and Haitham Kussaibi

    Citation: BMC Cancer 2018 18:170

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  21. Content type: Research article

    Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response. However, there is no consensus rega...

    Authors: Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng and Ming Kuang

    Citation: BMC Cancer 2018 18:117

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  22. Content type: Research article

    The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types ...

    Authors: María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma. Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla and Miguel Santibañez

    Citation: BMC Cancer 2018 18:112

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  23. Content type: Research article

    Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many c...

    Authors: Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder and Jeff Hammerbacher

    Citation: BMC Cancer 2018 18:87

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  24. Content type: Research article

    Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed cell death 1 (PD-1) therapy in multiple cancers, including triple negative breast cance...

    Authors: Ming Li, Anqi Li, Shuling Zhou, Yan Xu, Yaoxing Xiao, Rui Bi and Wentao Yang

    Citation: BMC Cancer 2018 18:4

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  25. Content type: Research article

    Immunologic factors can promote the progression of oral squamous cell carcinomas (oscc). The phylogenetic highly conserved protein Galectin 3 (Gal3) contributes to cell differentiation and immune homeostasis. ...

    Authors: Manuel Weber, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam and Falk Wehrhan

    Citation: BMC Cancer 2017 17:906

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  26. Content type: Software

    Adoptive immunotherapy offers great potential for treating many types of cancer but its clinical application is hampered by cross-reactive T cell responses in healthy human tissues, representing serious safety...

    Authors: Victor Jaravine, Anja Mösch, Silke Raffegerst, Dolores J. Schendel and Dmitrij Frishman

    Citation: BMC Cancer 2017 17:892

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  27. Content type: Research article

    The tumor immune environment not only modulates the effects of immunotherapy, but also the effects of other anticancer drugs and treatment outcomes. These immune responses can be evaluated with tumor-infiltrat...

    Authors: Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2017 17:888

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  28. Content type: Research article

    The primary aim of this study was to evaluate the safety of a novel dendritic cell (DC) vaccine pulsed with survivin and MUC1, silenced with suppressor of cytokine signaling 1 (SOCS1), and immune stimulated wi...

    Authors: Chunlei Ge, Ruilei Li, Haifeng Song, Tao Geng, Jinyan Yang, Qinghua Tan, Linfeng Song, Ying Wang, Yuanbo Xue, Zhen Li, Suwei Dong, Zhiwei Zhang, Na Zhang, Jiyin Guo, Lin Hua, Siyi Chen…

    Citation: BMC Cancer 2017 17:884

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  29. Content type: Research article

    The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily obtained from routine blood tests. We investigated the associations of the NLR and PLR with the clinical parameters an...

    Authors: Dan Liu, Yi Huang, Lei Li, Juan Song, Li Zhang and Weimin Li

    Citation: BMC Cancer 2017 17:882

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  30. Content type: Research article

    Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ with respect to their biology and genomic patterns, but inflammatory index variation did not fully investigate. This study aimed to exami...

    Authors: Lin Yang, Wenzhuo He, Pengfei Kong, Chang Jiang, Qiong Yang, Qiankun Xie and Liang Ping Xia

    Citation: BMC Cancer 2017 17:873

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  31. Content type: Research article

    The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancer...

    Authors: Cheng Chen, Qiu-Xia Qu, Fang Xie, Wei-Dong Zhu, Ye-Han Zhu and Jian-An Huang

    Citation: BMC Cancer 2017 17:652

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  32. Content type: Case report

    Extranodal NK/T-cell lymphoma (ENKTCL) reports from sub-Saharan Africa (SSA) are remarkably rare, despite early childhood acquisition and high prevalence of the causative infectious agent, Epstein-Barr virus (...

    Authors: Tamiwe Tomoka, Eric Powers, Toon van der Gronde, Amy Amuquandoh, Bal Mukunda Dhungel, Coxcilly Kampani, Steve Kamiza, Nathan D. Montgomery, Yuri Fedoriw and Satish Gopal

    Citation: BMC Cancer 2017 17:633

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  33. Content type: Case report

    Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there is no recommended standard therapy for relapsed NKTCL.

    Authors: Jianping Lai, Peng Xu, Xiaoliu Jiang, Shan Zhou and Anwen Liu

    Citation: BMC Cancer 2017 17:507

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  34. Content type: Research article

    Gastric adenocarcinoma is the third most common cause of cancer-associated death worldwide. Helicobacter pylori infection activates a signaling cascade that induces production of cytokines and chemokines involved...

    Authors: Norma Sánchez-Zauco, Javier Torres, Alejandro Gómez, Margarita Camorlinga-Ponce, Leopoldo Muñoz-Pérez, Roberto Herrera-Goepfert, Rafael Medrano-Guzmán, Silvia Giono-Cerezo and Carmen Maldonado-Bernal

    Citation: BMC Cancer 2017 17:384

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    The Correction to this article has been published in BMC Cancer 2017 17:669

  35. Content type: Research article

    Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori. We aimed to investi...

    Authors: Young Woon Chang, Chi Hyuk Oh, Jung-Wook Kim, Jae Won Lee, Mi Ju Park, Jae-Jun Shim, Chang Kyun Lee, Jae-Young Jang, Seok Ho Dong, Hyo Jong Kim, Sung Soo Kim and Byung-Ho Kim

    Citation: BMC Cancer 2017 17:388

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  36. Content type: Research article

    Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma.

    Authors: Juan Fang, Xiaoxu Li, Da Ma, Xiangqi Liu, Yichen Chen, Yun Wang, Vivian Wai Yan Lui, Juan Xia, Bin Cheng and Zhi Wang

    Citation: BMC Cancer 2017 17:375

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  37. Content type: Research article

    Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this stud...

    Authors: Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero and Jose Ponce-Lorenzo

    Citation: BMC Cancer 2017 17:320

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  38. Content type: Debate

    Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have als...

    Authors: Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas and Benjamin Roche

    Citation: BMC Cancer 2017 17:257

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  39. Content type: Research article

    Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti...

    Authors: Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte and William Raoul

    Citation: BMC Cancer 2017 17:220

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  40. Content type: Research article

    Gastric cancer is one of the most common and lethal type of cancer worldwide. Infection with Helicobacter pylori (H. pylori) is recognized as the major cause of gastric cancer. However, it remains unclear the mec...

    Authors: Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran and Marygorret Obonyo

    Citation: BMC Cancer 2017 17:133

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  41. Content type: Research article

    Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Authors: Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy

    Citation: BMC Cancer 2017 17:104

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  42. Content type: Research article

    Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to ...

    Authors: Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký and Jan Ženka

    Citation: BMC Cancer 2016 16:940

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  43. Content type: Research article

    Women living with HIV (WLWH) are at increased risk of persistent human papillomavirus (HPV) infection, cervical dysplasia and cervical cancer compared with women from the general population (WGP). We assessed ...

    Authors: Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde and Anne-Mette Lebech

    Citation: BMC Cancer 2016 16:866

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  44. Content type: Research article

    The aims of this study were to detect HPV E6/E7 mRNA expression in women with high-risk genotypes (HPV-16, -18, -31, -33 and -45) analysing its relationship with tissue pathology and 2) 2-year follow-up of E6/...

    Authors: Nerea Fontecha, Miren Basaras, Silvia Hernáez, Daniel Andía and Ramón Cisterna

    Citation: BMC Cancer 2016 16:852

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  45. Content type: Research article

    For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruz...

    Authors: Paula Abello-Cáceres, Javier Pizarro-Bauerle, Carlos Rosas, Ismael Maldonado, Lorena Aguilar-Guzmán, Carlos González, Galia Ramírez, Jorge Ferreira and Arturo Ferreira

    Citation: BMC Cancer 2016 16:731

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  46. Content type: Research article

    Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the mos...

    Authors: Ting Yue, Xiaodong Zheng, Yaling Dou, Xiaohu Zheng, Rui Sun, Zhigang Tian and Haiming Wei

    Citation: BMC Cancer 2016 16:665

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