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Section edited by Ian Cree
This section considers articles on all aspects of genome-scale analysis, functional genomics, genetic association studies, pharmacogenomics and epigenetics in relation to cancer biology, diagnosis and therapy.
Research article
Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70–80%) or in the related receptor PDGFRA (~10%). These GISTs genera...
BMC Cancer 2017 17:512
Published on: 2 August 2017
Research article
BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in ...
BMC Cancer 2017 17:496
Published on: 24 July 2017
Study protocol
The ‘common variant, common disease’ model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative eff...
BMC Cancer 2017 17:491
Published on: 18 July 2017
Research article
The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in...
BMC Cancer 2017 17:487
Published on: 17 July 2017
Research article
Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly ass...
BMC Cancer 2017 17:489
Published on: 17 July 2017
Research article
DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, t...
BMC Cancer 2017 17:469
Published on: 5 July 2017
Research article
Sequencing analysis of circulating tumor cells (CTCs) enables “liquid biopsy” to guide precision oncology strategies. However, this requires low-template whole genome amplification (WGA) that is prone to error...
BMC Cancer 2017 17:457
Published on: 1 July 2017
Research article
Epithelial to mesenchymal transition (EMT) is the process by which stationary epithelial cells transdifferentiate to mesenchymal cells with increased motility. EMT is integral in early stages of development an...
BMC Cancer 2017 17:447
Published on: 26 June 2017
Research article
Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. ...
BMC Cancer 2017 17:438
Published on: 21 June 2017
Research article
Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC...
BMC Cancer 2017 17:426
Published on: 19 June 2017
Research article
Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a precl...
BMC Cancer 2017 17:396
Published on: 2 June 2017
Research article
CUL4A has been known for its oncogenic properties in various human cancers. However, its role in intrahepatic cholangiocarcinoma (iCCA) has not been explored.
BMC Cancer 2017 17:395
Published on: 2 June 2017
Research article
The detection of somatic mutations in primary tumors is critical for the understanding of cancer evolution and targeting therapy. Multiple technologies have been developed to enable the detection of such mutat...
BMC Cancer 2017 17:358
Published on: 22 May 2017
Research article
Thymic adenocarcinoma is an extremely rare subtype of thymic epithelial tumors. Due to its rarity, there is currently no sequencing approach for thymic adenocarcinoma.
BMC Cancer 2017 17:330
Published on: 15 May 2017
Research article
Genetic factors may influence an individual’s sensitivity to ionising radiation and therefore modify his/her risk of developing papillary thyroid carcinoma (PTC). Previously, we reported that common single nuc...
BMC Cancer 2017 17:328
Published on: 12 May 2017
Research article
Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular me...
BMC Cancer 2017 17:306
Published on: 2 May 2017
Research article
Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids ...
BMC Cancer 2017 17:273
Published on: 17 April 2017
Research article
Breast carcinogenesis is a multistep process involving genetic and epigenetic changes. Tumor tissues are frequently characterized by gene-specific hypermethylation and global DNA hypomethylation. Aberrant DNA ...
BMC Cancer 2017 17:260
Published on: 12 April 2017
Research article
H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression.
BMC Cancer 2017 17:261
Published on: 12 April 2017
Research article
Mucin 1 (MUC1) contributes to the growth and metastasis of various cancers, including lung cancer, and MUC1 gene length polymorphisms are associated with susceptibility to lung cancer and its prognosis. In contra...
BMC Cancer 2017 17:263
Published on: 12 April 2017
