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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 9 of 10

  1. Content type: Research article

    Active vitamin D analogs that are less toxic than calcitriol can be useful in the combined treatment of patients suffering from colon cancer. In the present study we demonstrate, for the first time in an in vivo ...

    Authors: Magdalena Milczarek, Mateusz Psurski, Andrzej Kutner and Joanna Wietrzyk

    Citation: BMC Cancer 2013 13:294

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  2. Content type: Research article

    Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches.

    Authors: Kornelius Kerl, David Ries, Rebecca Unland, Christiane Borchert, Natalia Moreno, Martin Hasselblatt, Heribert Jürgens, Marcel Kool, Dennis Görlich, Maria Eveslage, Manfred Jung, Michael Meisterernst and Michael Frühwald

    Citation: BMC Cancer 2013 13:286

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  3. Content type: Research article

    Recent research has revealed that targeting mitochondrial bioenergetic metabolism is a promising chemotherapeutic strategy. Key to successful implementation of this chemotherapeutic strategy is the use of new ...

    Authors: Gang Cheng, Jacek Zielonka, Donna M McAllister, A Craig Mackinnon Jr, Joy Joseph, Michael B Dwinell and Balaraman Kalyanaraman

    Citation: BMC Cancer 2013 13:285

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  4. Content type: Research article

    Tamoxifen (TAM) is widely used in the chemotherapy of breast cancer and as a preventive agent against recurrence after surgery. However, extended TAM administration for breast cancer induces increased VEGF lev...

    Authors: B N Prashanth Kumar, Shashi Rajput, Kaushik Kumar Dey, Aditya Parekh, Subhasis Das, Abhijit Mazumdar and Mahitosh Mandal

    Citation: BMC Cancer 2013 13:273

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  5. Content type: Research article

    Malignant pleural mesothelioma (MPM) often develops decades following exposure to asbestos. Current best therapy produces a response in only half of patients, and the median survival with this therapy remains ...

    Authors: Ren Liu, Benjamin D Ferguson, Yue Zhou, Kranthi Naga, Ravi Salgia, Parkash S Gill and Valery Krasnoperov

    Citation: BMC Cancer 2013 13:269

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  6. Content type: Research article

    Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, vitamin C (Vit C) and butylated h...

    Authors: Bhupendra Singh, Anwesha Chatterjee, Amruta M Ronghe, Nimee K Bhat and Hari K Bhat

    Citation: BMC Cancer 2013 13:253

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  7. Content type: Technical advance

    Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evol...

    Authors: Hee-Sheung Lee, Nicholas CO Lee, Brenda R Grimes, Alexander Samoshkin, Artem V Kononenko, Ruchi Bansal, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina and Vladimir Larionov

    Citation: BMC Cancer 2013 13:252

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  8. Content type: Research article

    High-grade osteosarcoma is an aggressive tumor most often developing in the long bones of adolescents, with a second peak in the 5th decade of life. Better knowledge on cellular signaling in this tumor may ide...

    Authors: Marieke L Kuijjer, Elisabeth FP Peterse, Brendy EWM van den Akker, Inge H Briaire-de Bruijn, Massimo Serra, Leonardo A Meza-Zepeda, Ola Myklebost, A Bassim Hassan, Pancras CW Hogendoorn and Anne-Marie Cleton-Jansen

    Citation: BMC Cancer 2013 13:245

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  9. Content type: Research article

    Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer...

    Authors: Christiana Charalambous, Chara A Pitta and Andreas I Constantinou

    Citation: BMC Cancer 2013 13:238

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  10. Content type: Research article

    Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this ph...

    Authors: Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya and Takashi Joh

    Citation: BMC Cancer 2013 13:237

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  11. Content type: Research article

    Vascular endothelial growth factor-a (VEGF)-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, how...

    Authors: Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa and Kazuhito Rokutan

    Citation: BMC Cancer 2013 13:229

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  12. Content type: Research article

    Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive and associated with poor prognosis. Basic research to develop new treatment regimens is critically needed.

    Authors: Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita and Hiroshi Iwasaki

    Citation: BMC Cancer 2013 13:224

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  13. Content type: Research article

    Human and feline head and neck squamous cell carcinoma (HNSCC) share histology, certain molecular features, as well as locally aggressive and highly recurrent clinical behavior. In human HNSCC, the presence of...

    Authors: Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew and Elizabeth A McNiel

    Citation: BMC Cancer 2013 13:218

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  14. Content type: Research article

    New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signalin...

    Authors: Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky and Sarah J Freemantle

    Citation: BMC Cancer 2013 13:211

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  15. Content type: Research article

    Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and ...

    Authors: Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2013 13:198

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  16. Content type: Research article

    Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a ...

    Authors: Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus and Manuel L Penichet

    Citation: BMC Cancer 2013 13:195

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  17. Content type: Research article

    Pancreatic cancer remains one of the deadliest cancers due to lack of early detection and absence of effective treatments. Gemcitabine, the current standard-of-care chemotherapy for pancreatic cancer, has limi...

    Authors: Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks and C Max Schmidt

    Citation: BMC Cancer 2013 13:194

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  18. Content type: Research article

    Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while not abrogating the efficacy of radiothera...

    Authors: Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel and Melpo Christofidou-Solomidou

    Citation: BMC Cancer 2013 13:179

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  19. Content type: Research article

    Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-α2b alone or in combina...

    Authors: Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg and Chien-Hsing Chang

    Citation: BMC Cancer 2013 13:170

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  20. Content type: Research article

    Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose upt...

    Authors: Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard and Andreas Kjær

    Citation: BMC Cancer 2013 13:168

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  21. Content type: Research article

    It is important to simultaneously induce strong cell death and antitumor immunity in cancer patients for successful cancer treatment. Here, we investigated the cytotoxic and phenotypic modulation effects of th...

    Authors: Yun Choi, Ho Won Lee, Jaetae Lee and Yong Hyun Jeon

    Citation: BMC Cancer 2013 13:143

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  22. Content type: Research article

    Malignant pleural mesothelioma (MPM) is an aggressive malignancy closely associated with asbestos exposure and extremely resistant to current treatments. It exhibits a steady increase in incidence, thus necess...

    Authors: Bao-Zhu Yuan, Joshua Chapman, Min Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul and Steven H Reynolds

    Citation: BMC Cancer 2013 13:140

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  23. Content type: Study protocol

    The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades due to newly found associations with human papillomavirus (HPV) infection. Primary radiotherapy...

    Authors: Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle…

    Citation: BMC Cancer 2013 13:133

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  24. Content type: Technical advance

    Despite the potential of improving the delivery of epigenetic drugs, the subsequent assessment of changes in their epigenetic activity is largely dependent on the availability of a suitable and rapid screening...

    Authors: Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge and David F Callen

    Citation: BMC Cancer 2013 13:113

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  25. Content type: Research article

    Glioblastoma is one of the intractable cancers and is highly resistant to ionizing radiation. This radioresistance is partly due to the presence of a hypoxic region which is widely found in advanced malignant ...

    Authors: Hironobu Yasui, Taketoshi Asanuma, Junichi Kino, Tohru Yamamori, Shunsuke Meike, Masaki Nagane, Nobuo Kubota, Mikinori Kuwabara and Osamu Inanami

    Citation: BMC Cancer 2013 13:106

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  26. Content type: Research article

    Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by it...

    Authors: Anahid Ehteda, Peter Galettis, Krishna Pillai and David L Morris

    Citation: BMC Cancer 2013 13:86

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  27. Content type: Research article

    Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2.

    Authors: Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum and Sandeep Mittal

    Citation: BMC Cancer 2013 13:83

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  28. Content type: Research article

    Recent evidence indicates that methyl jasmonate (MJ), a plant stress hormone, exhibits anti-cancer activity on human cancer cells. The aim of this study is to determine whether sub-cytotoxic MJ can abolish the...

    Authors: Liduan Zheng, Dan Li, Xuan Xiang, Ling Tong, Meng Qi, Jiarui Pu, Kai Huang and Qiangsong Tong

    Citation: BMC Cancer 2013 13:74

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  29. Content type: Research article

    Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of ...

    Authors: Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh and Helmout Modjtahedi

    Citation: BMC Cancer 2013 13:41

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  30. Content type: Research article

    Interleukin-12 (IL-12) based radiosensitization is an effective way of tumor treatment. Local cytokine production, without systemic shedding, might provide clinical benefit in radiation treatment of sarcomas. ...

    Authors: Ales Sedlar, Simona Kranjc, Tanja Dolinsek, Maja Cemazar, Andrej Coer and Gregor Sersa

    Citation: BMC Cancer 2013 13:38

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  31. Content type: Research article

    Changes in cell shape and plasticity in cytoskeletal dynamics are critically involved in cell adhesion, migration, invasion and the overall process of metastasis. Previous work in our laboratory demonstrated t...

    Authors: BreeAnn N Brandhagen, Chelsea R Tieszen, Tara M Ulmer, Maria S Tracy, Alicia A Goyeneche and Carlos M Telleria

    Citation: BMC Cancer 2013 13:35

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  32. Content type: Research article

    A substantial number of breast cancer patients are identified as being at high risk of developing metastatic disease. With increasing number of targeted therapeutics entering clinical trials, chronic administr...

    Authors: Christian Schem, Dirk Bauerschlag, Sascha Bender, Ann-Christin Lorenzen, Daniel Loermann, Sigrid Hamann, Frank Rösel, Holger Kalthoff, Claus C Glüer, Walter Jonat and Sanjay Tiwari

    Citation: BMC Cancer 2013 13:32

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  33. Content type: Research article

    In the present study, we show that the combination of doxorubicin with the cyclin-dependent kinase inhibitor P276-00 was synergistic at suboptimal doses in the non-small cell lung carcinoma (NSCLC) cell lines ...

    Authors: Maggie J Rathos, Harshal Khanwalkar, Kavita Joshi, Sonal M Manohar and Kalpana S Joshi

    Citation: BMC Cancer 2013 13:29

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  34. Content type: Research article

    Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is ov...

    Authors: Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang and Jian Pan

    Citation: BMC Cancer 2012 12:619

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  35. Content type: Research article

    Tamoxifen is used in hormone therapy for estrogen-receptor (ER)-positive breast cancer, but also has chemopreventative effects against ER-negative breast cancers. This study sought to investigate whether oral ...

    Authors: Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano and Geoffrey W Krissansen

    Citation: BMC Cancer 2012 12:591

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  36. Content type: Research article

    Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1,...

    Authors: Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren and Stephen Safe

    Citation: BMC Cancer 2012 12:564

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  37. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Current therapies are insufficient, making HCC an intractable disease. Our previous studies confirmed that inhibi...

    Authors: Wei Li, Dao-Ming Li, Kai Chen, Zheng Chen, Yang Zong, Hong Yin, Ze-Kuan Xu, Yi Zhu, Fei-Ran Gong and Min Tao

    Citation: BMC Cancer 2012 12:547

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  38. Content type: Research article

    Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to ...

    Authors: Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam, Vijayaragavan Muralidharan and Christopher Christophi

    Citation: BMC Cancer 2012 12:522

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  39. Content type: Research article

    We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in the proliferation of normal mammary epithelium; h...

    Authors: John L McElwee, Sunish Mohanan, Obi L Griffith, Heike C Breuer, Lynne J Anguish, Brian D Cherrington, Ashley M Palmer, Louise R Howe, Venkataraman Subramanian, Corey P Causey, Paul R Thompson, Joe W Gray and Scott A Coonrod

    Citation: BMC Cancer 2012 12:500

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  40. Content type: Research article

    Despite strong efforts to improve clinical outcome of ovarian cancer patients by conventional and targeted immuno-based therapies, the prognosis of advanced ovarian cancer is still poor. Natural killer (NK) ce...

    Authors: Nina Gottschalk, Stephan Lang, Rainer Kimmig, Mahavir Singh and Sven Brandau

    Citation: BMC Cancer 2012 12:451

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  41. Content type: Research article

    Chemotherapeutic bioassay for colorectal cancer (CRC) with a rat model bearing chemically-induced CRCs plays an important role in the development of new anti-tumor drugs and regimens. Although several protocol...

    Authors: Kazuto Yoshimi, Takao Hashimoto, Yusuke Niwa, Kazuya Hata, Tadao Serikawa, Takuji Tanaka and Takashi Kuramoto

    Citation: BMC Cancer 2012 12:448

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  42. Content type: Research article

    DNA interstrand cross-links (ICLs) are critical lesions produced by several cancer chemotherapy agents including platinum drugs and nitrogen mustards. We have previously shown in haematological (multiple myelo...

    Authors: Victoria J Spanswick, Helen L Lowe, Claire Newton, John P Bingham, Alessia Bagnobianchi, Konstantinos Kiakos, Charles Craddock, Jonathan A Ledermann, Daniel Hochhauser and John A Hartley

    Citation: BMC Cancer 2012 12:436

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  43. Content type: Research article

    Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 5-deoxy-5-fluorouridine (5-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3...

    Authors: Laia Trigueros-Motos, Sandra Pérez-Torras, F Javier Casado, Míriam Molina-Arcas and Marçal Pastor-Anglada

    Citation: BMC Cancer 2012 12:434

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  44. Content type: Research article

    The CD34+CD38- subset of AML cells is enriched for resistance to current chemotherapeutic agents and considered to contribute to disease progression and relapse in Acute Myeloid Leukaemia (AML) patients following...

    Authors: Mays Jawad, Ning Yu, Claire Seedhouse, Karuna Tandon, Nigel H Russell and Monica Pallis

    Citation: BMC Cancer 2012 12:431

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  45. Content type: Research article

    Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellula...

    Authors: Fatima Rangwala, Kevin P Williams, Ginger R Smith, Zainab Thomas, Jennifer L Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A Morse and Gayathri R Devi

    Citation: BMC Cancer 2012 12:402

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  46. Content type: Research article

    Antiangiogenic agents that disrupt the vascular endothelial growth factor pathway have been demonstrated to normalize tumor vasculature and improve tumor oxygenation in some studies and to induce hypoxia in ot...

    Authors: Jon-Vidar Gaustad, Trude G Simonsen, Marit N Leinaas and Einar K Rofstad

    Citation: BMC Cancer 2012 12:388

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  47. Content type: Research article

    Hepatocellular carcinoma (HCC) still represents an unmet medical need. Epigenetic inactivation of tumor suppressor genes like RASSF1A or APC by overexpression of DNA methyltransferases (DNMTs) has been shown t...

    Authors: Steffen Zopf, Matthias Ocker, Daniel Neureiter, Beate Alinger, Susanne Gahr, Markus F Neurath and Pietro Di Fazio

    Citation: BMC Cancer 2012 12:386

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  48. Content type: Study protocol

    The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2) and uses Salmonella typhi Ty21a as a vector. The immune reaction elicited by VXM01 is expected to dis...

    Authors: Andreas G Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W Buchler, Moritz Koch, Jürgen Weitz, Walter E Haefeli and Friedrich H Schmitz-Winnenthal

    Citation: BMC Cancer 2012 12:361

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  49. Content type: Research article

    Limited penetration of anticancer drugs in solid tumours is a probable cause of drug resistance. Our previous results indicate that drug penetration depends on cellular packing density and adhesion between can...

    Authors: Rama H Grantab and Ian F Tannock

    Citation: BMC Cancer 2012 12:214

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