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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 9 of 11

  1. Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet availab...

    Authors: Jian Kang, C Marcelo Sergio, Robert L Sutherland and Elizabeth A Musgrove

    Citation: BMC Cancer 2014 14:32

    Content type: Research article

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  2. Recent studies have shown that glucosamine inhibits the proliferation of various human cancer cell lines and downregulates the activity of COX-2, HIF-1α, p70S6K, and transglutaminase 2. Because the IGF-1R/Akt ...

    Authors: Ki-Hoon Song, Ju-Hee Kang, Jong-Kyu Woo, Jeong-Seok Nam, Hye-Young Min, Ho-Young Lee, Soo-Youl Kim and Seung-Hyun Oh

    Citation: BMC Cancer 2014 14:31

    Content type: Research article

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  3. Arsenic trioxide (ATO) is reported to be an effective therapeutic agent in acute promyelocytic leukemia (APL) through inducing apoptotic cell death. Buthionine sulfoximine (BSO), an oxidative stress pathway mo...

    Authors: Yukie Tanaka, Takayuki Komatsu, Hiroko Shigemi, Takahiro Yamauchi and Yutaka Fujii

    Citation: BMC Cancer 2014 14:27

    Content type: Research article

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  4. Ceramide is a bioeffector that mediates various cellular processes, including apoptosis. However, the mechanism underlying ceramide function in apoptosis is apparently cell type-dependent and is not well-under...

    Authors: Amy V Paschall, Mary A Zimmerman, Christina M Torres, Dafeng Yang, May R Chen, Xia Li, Erhard Bieberich, Aiping Bai, Jacek Bielawski, Alicja Bielawska and Kebin Liu

    Citation: BMC Cancer 2014 14:24

    Content type: Research article

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  5. Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therape...

    Authors: Eun Jung Choi, Bong Jun Cho, David J Lee, Yeo Hyeon Hwang, Sun Ha Chun, Hans H Kim and In Ah Kim

    Citation: BMC Cancer 2014 14:17

    Content type: Research article

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  6. Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is ...

    Authors: Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang and Dong Wang

    Citation: BMC Cancer 2014 14:11

    Content type: Research article

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  7. Cortidis rhizoma (Huanglian) and its major therapeutic component, berberine, have drawn extensive attention in recent years for their anti-cancer properties. Growth inhibitory effects of berberine on multiple ty...

    Authors: Chi Man Tsang, Yuk Chun Cheung, Vivian Wai-Yan Lui, Yim Ling Yip, Guitao Zhang, Victor Weitao Lin, Kenneth Chat-Pan Cheung, Yibin Feng and Sai Wah Tsao

    Citation: BMC Cancer 2013 13:619

    Content type: Research article

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  8. Chk1 inhibitors have emerged as promising anticancer therapeutic agents particularly when combined with antimetabolites such as gemcitabine, cytarabine or hydroxyurea. Here, we address the importance of approp...

    Authors: Ryan Montano, Ruth Thompson, Injae Chung, Huagang Hou, Nadeem Khan and Alan Eastman

    Citation: BMC Cancer 2013 13:604

    Content type: Research article

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  9. Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptos...

    Authors: Zeze Fu, Biyong Deng, Yuxin Liao, Liancheng Shan, Fei Yin, Zhuoying Wang, Hui Zeng, Dongqing Zuo, Yingqi Hua and Zhengdong Cai

    Citation: BMC Cancer 2013 13:580

    Content type: Research article

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  10. Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migrati...

    Authors: Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans-Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann and Markus Greiner

    Citation: BMC Cancer 2013 13:574

    Content type: Research article

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  11. Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 ...

    Authors: Didier Kamioner, Stefan Fruehauf, Fréderic Maloisel, Laurent Cals, Stéphane Lepretre and Christian Berthou

    Citation: BMC Cancer 2013 13:547

    Content type: Study protocol

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  12. Recent studies have demonstrated that synthetic dsRNAs may produce therapeutic effects in a target-independent manner through stimulation of the toll-like receptor-3 (TLR3)/interferon pathway; as a result, ang...

    Authors: Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-Xin Zhang, Yin-Ze Wei, Yuan-Yuan Zhu and Jing Qin

    Citation: BMC Cancer 2013 13:527

    Content type: Research article

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  13. There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the trea...

    Authors: Quan Wang, Feng Wei, Guoyue Lv, Chunsheng Li, Tongjun Liu, Costas G Hadjipanayis, Guikai Zhang, Chunhai Hao and Anita C Bellail

    Citation: BMC Cancer 2013 13:521

    Content type: Research article

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  14. Recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. Pharmacological interventions that effectively enhance tumor cell death through activating ER stress h...

    Authors: Zhiguo Liu, Yusheng Sun, Luqing Ren, Yi Huang, Yuepiao Cai, Qiaoyou Weng, Xueqian Shen, Xiaokun Li, Guang Liang and Yi Wang

    Citation: BMC Cancer 2013 13:494

    Content type: Research article

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  15. Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic sali...

    Authors: Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff and Alireza Mirmohammadsadegh

    Citation: BMC Cancer 2013 13:490

    Content type: Research article

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  16. TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potent...

    Authors: Shanique K E Edwards, Carissa R Moore, Yan Liu, Sukhdeep Grewal, Lori R Covey and Ping Xie

    Citation: BMC Cancer 2013 13:481

    Content type: Research article

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  17. Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targe...

    Authors: Wen-guo Jiang, Xin-an Lu, Bo-yang Shang, Yan Fu, Sheng-hua Zhang, Daifu Zhou, Liang Li, Yi Li, Yongzhang Luo and Yong-su Zhen

    Citation: BMC Cancer 2013 13:479

    Content type: Research article

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  18. A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation o...

    Authors: Atsushi Baba, Masahito Shimizu, Tomohiko Ohno, Yohei Shirakami, Masaya Kubota, Takahiro Kochi, Daishi Terakura, Hisashi Tsurumi and Hisataka Moriwaki

    Citation: BMC Cancer 2013 13:465

    Content type: Research article

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  19. The optimal choice of cytotoxic drugs for intraperitoneal chemotherapy (IPC) in conjunction with cytoreductive surgery (CRS) for treatment of peritoneal carcinomatosis (PC) is poorly defined. We investigated d...

    Authors: Peter H Cashin, Haile Mahteme, Wilhelm Graf, Henning Karlsson, Rolf Larsson and Peter Nygren

    Citation: BMC Cancer 2013 13:435

    Content type: Research article

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  20. Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB. Tumor-derived exosomes c...

    Authors: Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon and Chul-Woo Kim

    Citation: BMC Cancer 2013 13:421

    Content type: Research article

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  21. Malignant mesotheliomas (MMs) are chemoresistant tumors related to exposure to asbestos fibers. The long latency period of MM (30-40 yrs) and heterogeneity of tumor presentation make MM difficult to diagnose a...

    Authors: Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry and Brooke T Mossman

    Citation: BMC Cancer 2013 13:400

    Content type: Research article

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  22. Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this work was to test pazopanib, an anti-tumoral and anti...

    Authors: Mercè Juliachs, August Vidal, Xavier Garcia del Muro, Josep M Piulats, Enric Condom, Oriol Casanovas, Mariona Graupera, Jose R Germà, Alberto Villanueva and Francesc Viñals

    Citation: BMC Cancer 2013 13:382

    Content type: Research article

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  23. Bronchial carcinoids are pulmonary neuroendocrine cell-derived tumors comprising typical (TC) and atypical (AC) malignant phenotypes. The 5-year survival rate in metastatic carcinoid, despite multiple current ...

    Authors: Reza Bayat Mokhtari, Sushil Kumar, Syed S Islam, Mehrdad Yazdanpanah, Khosrow Adeli, Ernest Cutz and Herman Yeger

    Citation: BMC Cancer 2013 13:378

    Content type: Research article

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  24. Drug resistance is a common cause of treatment failure in cancer patients and encompasses a multitude of different mechanisms. The aim of the present study was to identify drugs effective on multidrug resistan...

    Authors: Mårten Fryknäs, Joachim Gullbo, Xin Wang, Linda Rickardson, Malin Jarvius, Malin Wickström, Saadia Hassan, Claes Andersson, Mats Gustafsson, Gunnar Westman, Peter Nygren, Stig Linder and Rolf Larsson

    Citation: BMC Cancer 2013 13:374

    Content type: Research article

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  25. The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline trea...

    Authors: Lars Herfindal, Lene Myhren, Bjørn Tore Gjertsen, Stein Ove Døskeland and Gro Gausdal

    Citation: BMC Cancer 2013 13:341

    Content type: Research article

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  26. Melanoma represents one of the most aggressive and therapeutically challenging malignancies as it often gives rise to metastases and develops resistance to classical chemotherapeutic agents. Although diverse t...

    Authors: Valerie Kedinger, Aline Meulle, Omar Zounib, Marie-Elise Bonnet, Jean-Baptiste Gossart, Elodie Benoit, Melanie Messmer, Pattabhiraman Shankaranarayanan, Jean-Paul Behr, Patrick Erbacher and Anne-Laure Bolcato-Bellemin

    Citation: BMC Cancer 2013 13:338

    Content type: Research article

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  27. Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence...

    Authors: Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Steven Alexander and Cherie-Ann O Nathan

    Citation: BMC Cancer 2013 13:320

    Content type: Research article

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  28. Over-expression of epidermal growth factor receptor (EGFR) or insulin-like growth factor-1 receptor (IGF-1R) have been shown to closely correlate with radioresistance of breast cancer cells. This study aimed t...

    Authors: Ping Li, Marlon R Veldwijk, Qing Zhang, Zhao-bin Li, Wen-cai Xu and Shen Fu

    Citation: BMC Cancer 2013 13:297

    Content type: Research article

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  29. Active vitamin D analogs that are less toxic than calcitriol can be useful in the combined treatment of patients suffering from colon cancer. In the present study we demonstrate, for the first time in an in vivo ...

    Authors: Magdalena Milczarek, Mateusz Psurski, Andrzej Kutner and Joanna Wietrzyk

    Citation: BMC Cancer 2013 13:294

    Content type: Research article

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  30. Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches.

    Authors: Kornelius Kerl, David Ries, Rebecca Unland, Christiane Borchert, Natalia Moreno, Martin Hasselblatt, Heribert Jürgens, Marcel Kool, Dennis Görlich, Maria Eveslage, Manfred Jung, Michael Meisterernst and Michael Frühwald

    Citation: BMC Cancer 2013 13:286

    Content type: Research article

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  31. Recent research has revealed that targeting mitochondrial bioenergetic metabolism is a promising chemotherapeutic strategy. Key to successful implementation of this chemotherapeutic strategy is the use of new ...

    Authors: Gang Cheng, Jacek Zielonka, Donna M McAllister, A Craig Mackinnon Jr, Joy Joseph, Michael B Dwinell and Balaraman Kalyanaraman

    Citation: BMC Cancer 2013 13:285

    Content type: Research article

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  32. Tamoxifen (TAM) is widely used in the chemotherapy of breast cancer and as a preventive agent against recurrence after surgery. However, extended TAM administration for breast cancer induces increased VEGF lev...

    Authors: B N Prashanth Kumar, Shashi Rajput, Kaushik Kumar Dey, Aditya Parekh, Subhasis Das, Abhijit Mazumdar and Mahitosh Mandal

    Citation: BMC Cancer 2013 13:273

    Content type: Research article

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  33. Malignant pleural mesothelioma (MPM) often develops decades following exposure to asbestos. Current best therapy produces a response in only half of patients, and the median survival with this therapy remains ...

    Authors: Ren Liu, Benjamin D Ferguson, Yue Zhou, Kranthi Naga, Ravi Salgia, Parkash S Gill and Valery Krasnoperov

    Citation: BMC Cancer 2013 13:269

    Content type: Research article

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  34. Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, vitamin C (Vit C) and butylated h...

    Authors: Bhupendra Singh, Anwesha Chatterjee, Amruta M Ronghe, Nimee K Bhat and Hari K Bhat

    Citation: BMC Cancer 2013 13:253

    Content type: Research article

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  35. Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evol...

    Authors: Hee-Sheung Lee, Nicholas CO Lee, Brenda R Grimes, Alexander Samoshkin, Artem V Kononenko, Ruchi Bansal, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina and Vladimir Larionov

    Citation: BMC Cancer 2013 13:252

    Content type: Technical advance

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  36. High-grade osteosarcoma is an aggressive tumor most often developing in the long bones of adolescents, with a second peak in the 5th decade of life. Better knowledge on cellular signaling in this tumor may ide...

    Authors: Marieke L Kuijjer, Elisabeth FP Peterse, Brendy EWM van den Akker, Inge H Briaire-de Bruijn, Massimo Serra, Leonardo A Meza-Zepeda, Ola Myklebost, A Bassim Hassan, Pancras CW Hogendoorn and Anne-Marie Cleton-Jansen

    Citation: BMC Cancer 2013 13:245

    Content type: Research article

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  37. Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer...

    Authors: Christiana Charalambous, Chara A Pitta and Andreas I Constantinou

    Citation: BMC Cancer 2013 13:238

    Content type: Research article

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  38. Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this ph...

    Authors: Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya and Takashi Joh

    Citation: BMC Cancer 2013 13:237

    Content type: Research article

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  39. Vascular endothelial growth factor-a (VEGF)-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, how...

    Authors: Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa and Kazuhito Rokutan

    Citation: BMC Cancer 2013 13:229

    Content type: Research article

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  40. Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive and associated with poor prognosis. Basic research to develop new treatment regimens is critically needed.

    Authors: Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita and Hiroshi Iwasaki

    Citation: BMC Cancer 2013 13:224

    Content type: Research article

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  41. Human and feline head and neck squamous cell carcinoma (HNSCC) share histology, certain molecular features, as well as locally aggressive and highly recurrent clinical behavior. In human HNSCC, the presence of...

    Authors: Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew and Elizabeth A McNiel

    Citation: BMC Cancer 2013 13:218

    Content type: Research article

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  42. New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signalin...

    Authors: Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky and Sarah J Freemantle

    Citation: BMC Cancer 2013 13:211

    Content type: Research article

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  43. Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and ...

    Authors: Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2013 13:198

    Content type: Research article

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  44. Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a ...

    Authors: Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus and Manuel L Penichet

    Citation: BMC Cancer 2013 13:195

    Content type: Research article

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  45. Pancreatic cancer remains one of the deadliest cancers due to lack of early detection and absence of effective treatments. Gemcitabine, the current standard-of-care chemotherapy for pancreatic cancer, has limi...

    Authors: Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks and C Max Schmidt

    Citation: BMC Cancer 2013 13:194

    Content type: Research article

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  46. Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while not abrogating the efficacy of radiothera...

    Authors: Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel and Melpo Christofidou-Solomidou

    Citation: BMC Cancer 2013 13:179

    Content type: Research article

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  47. Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-α2b alone or in combina...

    Authors: Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg and Chien-Hsing Chang

    Citation: BMC Cancer 2013 13:170

    Content type: Research article

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  48. Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose upt...

    Authors: Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard and Andreas Kjær

    Citation: BMC Cancer 2013 13:168

    Content type: Research article

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