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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 8 of 10

  1. Content type: Research article

    Medulloblastoma is the most common type of pediatric brain tumor. Although numerous factors influence patient survival rates, more than 30% of all cases will ultimately be refractory to conventional therapies....

    Authors: Brian Hutzen, Hemant Kumar Bid, Peter J Houghton, Christopher R Pierson, Kimerly Powell, Anna Bratasz, Corey Raffel and Adam W Studebaker

    Citation: BMC Cancer 2014 14:206

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  2. Content type: Debate

    Companion animals like dogs frequently develop tumors with age and similarly to human malignancies, display interpatient tumoral heterogeneity. Tumors are frequently characterized with regard to their mutation...

    Authors: Nicole Grosse, Barbara van Loon and Carla Rohrer Bley

    Citation: BMC Cancer 2014 14:203

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  3. Content type: Research article

    Vasculogenic mimicry (VM) is a novel tumor blood supply in some highly aggressive malignant tumors. Recently, we reported VM existed in gallbladder carcinomas (GBCs) and the formation of the special passage th...

    Authors: Jing-Tao Zhang, Wei Sun, Wen-Zhong Zhang, Chun-Yan Ge, Zhong-Yan Liu, Ze-Ming Zhao, Xing-Sui Lu and Yue-Zu Fan

    Citation: BMC Cancer 2014 14:193

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  4. Content type: Research article

    Ewing’s sarcoma (ES) is the second most frequent primitive malignant bone tumor in adolescents with a very poor prognosis for high risk patients, mainly when lung metastases are detected (overall survival <15%...

    Authors: Guillaume Odri, Pui-Pui Kim, François Lamoureux, Céline Charrier, Séverine Battaglia, Jérôme Amiaud, Dominique Heymann, François Gouin and Françoise Redini

    Citation: BMC Cancer 2014 14:169

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  5. Content type: Research article

    Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and ...

    Authors: Lucio Tentori, Lucia Ricci-Vitiani, Alessia Muzi, Fabio Ciccarone, Federica Pelacchi, Roberta Calabrese, Daniele Runci, Roberto Pallini, Paola Caiafa and Grazia Graziani

    Citation: BMC Cancer 2014 14:151

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  6. Content type: Research article

    Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastro...

    Authors: Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan and Denghai Zhang

    Citation: BMC Cancer 2014 14:146

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  7. Content type: Research article

    The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evalu...

    Authors: Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang and Basil Rigas

    Citation: BMC Cancer 2014 14:141

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  8. Content type: Research article

    Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and...

    Authors: Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli and Katia Scotlandi

    Citation: BMC Cancer 2014 14:137

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  9. Content type: Research article

    Hepatocellular carcinoma (HCC) is a primary liver tumor and is the most difficult human malignancy to treat. In this study, we sought to develop an integrative approach in which real-time tumor monitoring, gen...

    Authors: Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao and Wei Xiong

    Citation: BMC Cancer 2014 14:114

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  10. Content type: Research article

    There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypert...

    Authors: Ting Li, Qunling Zhang, Jian Zhang, Gong Yang, Zhimin Shao, Jianmin Luo, Minhao Fan, Chen Ni, Zhenhua Wu and Xichun Hu

    Citation: BMC Cancer 2014 14:96

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  11. Content type: Research article

    A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites. CSC...

    Authors: Zhihong Chen, Lora W Forman, Robert M Williams and Douglas V Faller

    Citation: BMC Cancer 2014 14:90

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  12. Content type: Research article

    Esterases are often overexpressed in cancer cells and can have chiral specificities different from that of the corresponding normal tissues. For this reason, ester prodrugs could be a promising approach in che...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Victor Paromov, Marianne Brannon, Koyamangalath Krishnan and William L Stone

    Citation: BMC Cancer 2014 14:77

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  13. Content type: Research article

    Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent ...

    Authors: Jing Xu, Amit Singh and Mansoor M Amiji

    Citation: BMC Cancer 2014 14:75

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  14. Content type: Research article

    Triple-negative breast cancer (TNBC) is defined by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Breast cancers with a BRCA1 mutation are a...

    Authors: Tidarat Nhukeaw, Pornvichai Temboot, Kanidtha Hansongnern and Adisorn Ratanaphan

    Citation: BMC Cancer 2014 14:73

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  15. Content type: Research article

    Prognosis of adult patients suffering from acute lymphoblastic leukemia (ALL) is still unsatisfactory. Targeted therapy via inhibition of deregulated signaling pathways appears to be a promising therapeutic op...

    Authors: Christin Kretzschmar, Catrin Roolf, Tina-Susann Langhammer, Anett Sekora, Anahit Pews-Davtyan, Matthias Beller, Moritz J Frech, Christian Eisenlöffel, Arndt Rolfs and Christian Junghanss

    Citation: BMC Cancer 2014 14:71

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  16. Content type: Research article

    Metformin is an approved drug prescribed for diabetes. Its role as an anti-cancer agent has drawn significant attention because of its minimal side effects and low cost. However, its mechanism of anti-tumour a...

    Authors: Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger and Helmut Klocker

    Citation: BMC Cancer 2014 14:52

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  17. Content type: Research article

    Combination therapy is key to improving cancer treatment efficacy. Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, increases the cytotoxicity of several anticancer drugs. Apicularen A induce...

    Authors: Kang-Sik Seo, Jong-Seok Kim, Ji-Hoon Park, Kyoung-Sub Song, Eun-Jin Yun, Jong-Il Park, Gi Ryang Kweon, Wan-Hee Yoon, Kyu Lim and Byung-Doo Hwang

    Citation: BMC Cancer 2014 14:36

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  18. Content type: Research article

    The targeted delivery of cancer therapeutics represents an ongoing challenge in the field of drug development. TRAIL is a promising cancer drug but its activity profile could benefit from a cancer-selective de...

    Authors: Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A Powell, David G Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G Hawkins and Dirk Spitzer

    Citation: BMC Cancer 2014 14:35

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  19. Content type: Research article

    Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet availab...

    Authors: Jian Kang, C Marcelo Sergio, Robert L Sutherland and Elizabeth A Musgrove

    Citation: BMC Cancer 2014 14:32

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  20. Content type: Research article

    Recent studies have shown that glucosamine inhibits the proliferation of various human cancer cell lines and downregulates the activity of COX-2, HIF-1α, p70S6K, and transglutaminase 2. Because the IGF-1R/Akt ...

    Authors: Ki-Hoon Song, Ju-Hee Kang, Jong-Kyu Woo, Jeong-Seok Nam, Hye-Young Min, Ho-Young Lee, Soo-Youl Kim and Seung-Hyun Oh

    Citation: BMC Cancer 2014 14:31

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  21. Content type: Research article

    Arsenic trioxide (ATO) is reported to be an effective therapeutic agent in acute promyelocytic leukemia (APL) through inducing apoptotic cell death. Buthionine sulfoximine (BSO), an oxidative stress pathway mo...

    Authors: Yukie Tanaka, Takayuki Komatsu, Hiroko Shigemi, Takahiro Yamauchi and Yutaka Fujii

    Citation: BMC Cancer 2014 14:27

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  22. Content type: Research article

    Ceramide is a bioeffector that mediates various cellular processes, including apoptosis. However, the mechanism underlying ceramide function in apoptosis is apparently cell type-dependent and is not well-under...

    Authors: Amy V Paschall, Mary A Zimmerman, Christina M Torres, Dafeng Yang, May R Chen, Xia Li, Erhard Bieberich, Aiping Bai, Jacek Bielawski, Alicja Bielawska and Kebin Liu

    Citation: BMC Cancer 2014 14:24

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  23. Content type: Research article

    Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therape...

    Authors: Eun Jung Choi, Bong Jun Cho, David J Lee, Yeo Hyeon Hwang, Sun Ha Chun, Hans H Kim and In Ah Kim

    Citation: BMC Cancer 2014 14:17

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  24. Content type: Research article

    Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is ...

    Authors: Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang and Dong Wang

    Citation: BMC Cancer 2014 14:11

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  25. Content type: Research article

    Cortidis rhizoma (Huanglian) and its major therapeutic component, berberine, have drawn extensive attention in recent years for their anti-cancer properties. Growth inhibitory effects of berberine on multiple ty...

    Authors: Chi Man Tsang, Yuk Chun Cheung, Vivian Wai-Yan Lui, Yim Ling Yip, Guitao Zhang, Victor Weitao Lin, Kenneth Chat-Pan Cheung, Yibin Feng and Sai Wah Tsao

    Citation: BMC Cancer 2013 13:619

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  26. Content type: Research article

    Chk1 inhibitors have emerged as promising anticancer therapeutic agents particularly when combined with antimetabolites such as gemcitabine, cytarabine or hydroxyurea. Here, we address the importance of approp...

    Authors: Ryan Montano, Ruth Thompson, Injae Chung, Huagang Hou, Nadeem Khan and Alan Eastman

    Citation: BMC Cancer 2013 13:604

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  27. Content type: Research article

    Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptos...

    Authors: Zeze Fu, Biyong Deng, Yuxin Liao, Liancheng Shan, Fei Yin, Zhuoying Wang, Hui Zeng, Dongqing Zuo, Yingqi Hua and Zhengdong Cai

    Citation: BMC Cancer 2013 13:580

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  28. Content type: Research article

    Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migrati...

    Authors: Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans-Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann and Markus Greiner

    Citation: BMC Cancer 2013 13:574

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  29. Content type: Study protocol

    Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 ...

    Authors: Didier Kamioner, Stefan Fruehauf, Fréderic Maloisel, Laurent Cals, Stéphane Lepretre and Christian Berthou

    Citation: BMC Cancer 2013 13:547

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  30. Content type: Research article

    Recent studies have demonstrated that synthetic dsRNAs may produce therapeutic effects in a target-independent manner through stimulation of the toll-like receptor-3 (TLR3)/interferon pathway; as a result, ang...

    Authors: Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-Xin Zhang, Yin-Ze Wei, Yuan-Yuan Zhu and Jing Qin

    Citation: BMC Cancer 2013 13:527

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  31. Content type: Research article

    There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the trea...

    Authors: Quan Wang, Feng Wei, Guoyue Lv, Chunsheng Li, Tongjun Liu, Costas G Hadjipanayis, Guikai Zhang, Chunhai Hao and Anita C Bellail

    Citation: BMC Cancer 2013 13:521

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  32. Content type: Research article

    Recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. Pharmacological interventions that effectively enhance tumor cell death through activating ER stress h...

    Authors: Zhiguo Liu, Yusheng Sun, Luqing Ren, Yi Huang, Yuepiao Cai, Qiaoyou Weng, Xueqian Shen, Xiaokun Li, Guang Liang and Yi Wang

    Citation: BMC Cancer 2013 13:494

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  33. Content type: Research article

    Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic sali...

    Authors: Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff and Alireza Mirmohammadsadegh

    Citation: BMC Cancer 2013 13:490

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  34. Content type: Research article

    TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potent...

    Authors: Shanique K E Edwards, Carissa R Moore, Yan Liu, Sukhdeep Grewal, Lori R Covey and Ping Xie

    Citation: BMC Cancer 2013 13:481

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  35. Content type: Research article

    Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targe...

    Authors: Wen-guo Jiang, Xin-an Lu, Bo-yang Shang, Yan Fu, Sheng-hua Zhang, Daifu Zhou, Liang Li, Yi Li, Yongzhang Luo and Yong-su Zhen

    Citation: BMC Cancer 2013 13:479

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  36. Content type: Research article

    A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation o...

    Authors: Atsushi Baba, Masahito Shimizu, Tomohiko Ohno, Yohei Shirakami, Masaya Kubota, Takahiro Kochi, Daishi Terakura, Hisashi Tsurumi and Hisataka Moriwaki

    Citation: BMC Cancer 2013 13:465

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  37. Content type: Research article

    The optimal choice of cytotoxic drugs for intraperitoneal chemotherapy (IPC) in conjunction with cytoreductive surgery (CRS) for treatment of peritoneal carcinomatosis (PC) is poorly defined. We investigated d...

    Authors: Peter H Cashin, Haile Mahteme, Wilhelm Graf, Henning Karlsson, Rolf Larsson and Peter Nygren

    Citation: BMC Cancer 2013 13:435

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  38. Content type: Research article

    Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB. Tumor-derived exosomes c...

    Authors: Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon and Chul-Woo Kim

    Citation: BMC Cancer 2013 13:421

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  39. Content type: Research article

    Malignant mesotheliomas (MMs) are chemoresistant tumors related to exposure to asbestos fibers. The long latency period of MM (30-40 yrs) and heterogeneity of tumor presentation make MM difficult to diagnose a...

    Authors: Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry and Brooke T Mossman

    Citation: BMC Cancer 2013 13:400

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  40. Content type: Research article

    Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this work was to test pazopanib, an anti-tumoral and anti...

    Authors: Mercè Juliachs, August Vidal, Xavier Garcia del Muro, Josep M Piulats, Enric Condom, Oriol Casanovas, Mariona Graupera, Jose R Germà, Alberto Villanueva and Francesc Viñals

    Citation: BMC Cancer 2013 13:382

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  41. Content type: Research article

    Bronchial carcinoids are pulmonary neuroendocrine cell-derived tumors comprising typical (TC) and atypical (AC) malignant phenotypes. The 5-year survival rate in metastatic carcinoid, despite multiple current ...

    Authors: Reza Bayat Mokhtari, Sushil Kumar, Syed S Islam, Mehrdad Yazdanpanah, Khosrow Adeli, Ernest Cutz and Herman Yeger

    Citation: BMC Cancer 2013 13:378

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  42. Content type: Research article

    Drug resistance is a common cause of treatment failure in cancer patients and encompasses a multitude of different mechanisms. The aim of the present study was to identify drugs effective on multidrug resistan...

    Authors: Mårten Fryknäs, Joachim Gullbo, Xin Wang, Linda Rickardson, Malin Jarvius, Malin Wickström, Saadia Hassan, Claes Andersson, Mats Gustafsson, Gunnar Westman, Peter Nygren, Stig Linder and Rolf Larsson

    Citation: BMC Cancer 2013 13:374

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  43. Content type: Research article

    The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline trea...

    Authors: Lars Herfindal, Lene Myhren, Bjørn Tore Gjertsen, Stein Ove Døskeland and Gro Gausdal

    Citation: BMC Cancer 2013 13:341

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  44. Content type: Research article

    Melanoma represents one of the most aggressive and therapeutically challenging malignancies as it often gives rise to metastases and develops resistance to classical chemotherapeutic agents. Although diverse t...

    Authors: Valerie Kedinger, Aline Meulle, Omar Zounib, Marie-Elise Bonnet, Jean-Baptiste Gossart, Elodie Benoit, Melanie Messmer, Pattabhiraman Shankaranarayanan, Jean-Paul Behr, Patrick Erbacher and Anne-Laure Bolcato-Bellemin

    Citation: BMC Cancer 2013 13:338

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  45. Content type: Research article

    Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence...

    Authors: Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Steven Alexander and Cherie-Ann O Nathan

    Citation: BMC Cancer 2013 13:320

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  46. Content type: Research article

    Over-expression of epidermal growth factor receptor (EGFR) or insulin-like growth factor-1 receptor (IGF-1R) have been shown to closely correlate with radioresistance of breast cancer cells. This study aimed t...

    Authors: Ping Li, Marlon R Veldwijk, Qing Zhang, Zhao-bin Li, Wen-cai Xu and Shen Fu

    Citation: BMC Cancer 2013 13:297

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