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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 7 of 11

  1. Content type: Research article

    Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki

    Citation: BMC Cancer 2015 15:82

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  2. Content type: Research article

    Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in p...

    Authors: Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler and Sven Arke Lang

    Citation: BMC Cancer 2015 15:71

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  3. Content type: Research article

    Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) act...

    Authors: Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez

    Citation: BMC Cancer 2015 15:34

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  4. Content type: Research article

    Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. How...

    Authors: Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez

    Citation: BMC Cancer 2015 15:21

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  5. Content type: Research article

    Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...

    Authors: Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong and Kyung Seok Han

    Citation: BMC Cancer 2015 15:19

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  6. Content type: Research article

    DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli

    Citation: BMC Cancer 2015 15:17

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  7. Content type: Research article

    Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai

    Citation: BMC Cancer 2014 14:987

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  8. Content type: Research article

    Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recu...

    Authors: Andrea Khong, Amanda L Cleaver, Muhammad Fahmi Alatas, Ben C Wylie, Theresa Connor, Scott A Fisher, Steve Broomfield, Willem J Lesterhuis, Andrew J Currie, Richard A Lake and Bruce W Robinson

    Citation: BMC Cancer 2014 14:969

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  9. Content type: Research article

    Inhibition of metastasis through upregulation of immune surveillance is a major purpose of chemokine gene therapy. In this study, we focused on a membrane-bound chemokine CXCL16, which has shown a correlation ...

    Authors: Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Koichi Tsuneyama, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Ichiro Takasaki, Akiko Inujima, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi

    Citation: BMC Cancer 2014 14:949

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  10. Content type: Research article

    Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone

    Citation: BMC Cancer 2014 14:918

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  11. Content type: Research article

    The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes

    Citation: BMC Cancer 2014 14:916

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  12. Content type: Research article

    The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour mode...

    Authors: Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen and Michael R Horsman

    Citation: BMC Cancer 2014 14:903

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  13. Content type: Research article

    A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan

    Citation: BMC Cancer 2014 14:889

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  14. Content type: Research article

    Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell in...

    Authors: Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh and Takuya Matsunaga

    Citation: BMC Cancer 2014 14:882

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  15. Content type: Research article

    The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we...

    Authors: John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli and Per Sunnerhagen

    Citation: BMC Cancer 2014 14:853

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  16. Content type: Research article

    The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer respon...

    Authors: Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust and Leszek Wojnowski

    Citation: BMC Cancer 2014 14:842

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  17. Content type: Research article

    Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. New treatment options for the disease are needed. In this study, we identified and evaluated tumor vascular PLVAP as a therapeutic tar...

    Authors: Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang and Kuo-Jang Kao

    Citation: BMC Cancer 2014 14:815

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  18. Content type: Research article

    Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...

    Authors: Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran

    Citation: BMC Cancer 2014 14:800

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  19. Content type: Research article

    Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell l...

    Authors: Zhaoyang Lu, Jiabei Wang, Tongsen Zheng, Yingjian Liang, Dalong Yin, Ruipeng Song, Tiemin Pei, Shangha Pan, Hongchi Jiang and Lianxin Liu

    Citation: BMC Cancer 2014 14:783

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  20. Content type: Research article

    Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bac...

    Authors: Jaspreet Kaur Dhanjal, Nupur Nigam, Sudhanshu Sharma, Anupama Chaudhary, Sunil C Kaul, Abhinav Grover and Renu Wadhwa

    Citation: BMC Cancer 2014 14:775

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  21. Content type: Research article

    Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with s...

    Authors: Jing Wang, Song Gu, Jun Huang, Sheng Chen, Zhen Zhang and Min Xu

    Citation: BMC Cancer 2014 14:768

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  22. Content type: Research article

    Atorvastatin is a potent inhibitor of the mevalonate pathway and widely used as a hypolipidemic drug. Some epidemiological studies and animal experiments indicate that the long-term use of atorvastatin and str...

    Authors: Albert Braeuning, Philip Bucher, Ute Hofmann, Albrecht Buchmann and Michael Schwarz

    Citation: BMC Cancer 2014 14:766

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  23. Content type: Research article

    Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, s...

    Authors: Robert J Canter, Erik Ames, Stephanie Mac, Steven K Grossenbacher, Mingyi Chen, Chin-Shang Li, Dariusz Borys, Rachel C Smith, Joe Tellez, Thomas J Sayers, Arta M Monjazeb and William J Murphy

    Citation: BMC Cancer 2014 14:756

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  24. Content type: Research article

    Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented ...

    Authors: Emily R Theisen, Snehal Gajiwala, Jared Bearss, Venkataswamy Sorna, Sunil Sharma and Margit Janat-Amsbury

    Citation: BMC Cancer 2014 14:752

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  25. Content type: Research article

    We investigated the role of the HIPK2–p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments.

    Authors: Lihong Zhou, Yuanyuan Feng, Yongjie Jin, Xuan Liu, Hua Sui, Ni Chai, Xingzhu Chen, Ningning Liu, Qing Ji, Yan Wang and Qi Li

    Citation: BMC Cancer 2014 14:747

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  26. Content type: Research article

    The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea and Lorenza Díaz

    Citation: BMC Cancer 2014 14:745

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  27. Content type: Research article

    Castration resistant prostate cancer (CRPC) is a leading cause of cancer-related deaths in men. The primary cause of mortality and morbidity in patients is bone metastases and remodeling resulting in osteoblas...

    Authors: Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li

    Citation: BMC Cancer 2014 14:742

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  28. Content type: Research article

    The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might...

    Authors: Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin and Jun Peng

    Citation: BMC Cancer 2014 14:729

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  29. Content type: Research article

    Pancreatic cancer is frequently resistant to cancer therapeutics. Smoking and alcoholism are risk factors and pancreatic cancer patients often undergo nicotine replacement therapy (NRT) and treatment for alcoh...

    Authors: Jheelam Banerjee, Hussein AN Al-Wadei, Mohammed H Al-Wadei, Koami Dagnon and Hildegard M Schuller

    Citation: BMC Cancer 2014 14:725

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  30. Content type: Research article

    Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causes a mixed or hybrid form of concurrent a...

    Authors: Dongdong Chen, Mingke Song, Osama Mohamad and Shan Ping Yu

    Citation: BMC Cancer 2014 14:716

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  31. Content type: Research article

    Transduction of human mesenchymal stem cells (MSCs) with type 5 adenoviruses (Ad5) is limited in the efficacy because of the poor expression level of the coxsackie adenovirus receptor (CAR) molecules. We exami...

    Authors: Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi and Masatoshi Tagawa

    Citation: BMC Cancer 2014 14:713

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  32. Content type: Research article

    Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research ...

    Authors: Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan and Weidong Zhang

    Citation: BMC Cancer 2014 14:689

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  33. Content type: Research article

    Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, an...

    Authors: Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu and Qingyong Ma

    Citation: BMC Cancer 2014 14:686

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  34. Content type: Research article

    Crizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). To evaluate the effica...

    Authors: Haili Qian, Feng Gao, Haijuan Wang and Fei Ma

    Citation: BMC Cancer 2014 14:683

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  35. Content type: Research article

    Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR b...

    Authors: Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray and Francis J Hornicek

    Citation: BMC Cancer 2014 14:681

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  36. Content type: Research article

    Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodr...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan and William L Stone

    Citation: BMC Cancer 2014 14:675

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  37. Content type: Research article

    Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Here, we reported the effect of AChE on gastric cancer therapy.

    Authors: Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu and Liang Chu

    Citation: BMC Cancer 2014 14:668

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  38. Content type: Research article

    Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis....

    Authors: Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles and James A Thomson

    Citation: BMC Cancer 2014 14:621

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  39. Content type: Research article

    Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients’ quality of life, yet effecti...

    Authors: Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont and Stanley K Liu

    Citation: BMC Cancer 2014 14:614

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  40. Content type: Research article

    Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed. Targeting DNA repair pathways to sensitize tumor cells to chemo- or radiotherapy is under inve...

    Authors: Clément Guillot, Vincent Favaudon, Zdenko Herceg, Charlotte Sagne, Sylvie Sauvaigo, Philippe Merle, Janet Hall and Isabelle Chemin

    Citation: BMC Cancer 2014 14:603

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  41. Content type: Research article

    Despite advances in the treatment of primary breast tumors, the outcome of metastatic breast cancer remains dismal. Brain metastases present a particularly difficult therapeutic target due to the “sanctuary” s...

    Authors: Yuriy Shapovalov, Martha Zettel, Sara C Spielman, Stacy A Amico-Ruvio, Emily A Kelly, Grayson O Sipe, Ian M Dickerson, Ania K Majewska and Edward B Brown

    Citation: BMC Cancer 2014 14:598

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  42. Content type: Research article

    The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAI...

    Authors: Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen and Moul Dey

    Citation: BMC Cancer 2014 14:591

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  43. Content type: Research article

    A specific targeting modality for hepatocellular carcinoma (HCC) could ideally encompass a liver cell specific delivery system of a transcriptional unit that is active only in neoplastic cells. Sendai virosome...

    Authors: Mohammad Khalid Zakaria, Imran Khan, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha

    Citation: BMC Cancer 2014 14:582

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  44. Content type: Research article

    Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers with underlying DNA repair, DN...

    Authors: Christopher Bryant, Rebecca Rawlinson and Andrew J Massey

    Citation: BMC Cancer 2014 14:570

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  45. Content type: Research article

    Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-in...

    Authors: Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya and Siddhartha Sankar Jana

    Citation: BMC Cancer 2014 14:567

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  46. Content type: Research article

    We previously reported that 3'-ethynylcytidine (ECyd, TAS-106), an RNA polymerases inhibitor, enhances the anti-tumor efficacy of platinum in several tumor types in both in vitro and in vivo tumor models. However...

    Authors: Hiroto Fukushima, Tetsuya Abe, Kazuki Sakamoto, Hiroaki Tsujimoto, Shinji Mizuarai and Shinji Oie

    Citation: BMC Cancer 2014 14:562

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  47. Content type: Research article

    Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular activ...

    Authors: Takahiro Yamauchi, Kanako Uzui, Rie Nishi, Hiroko Shigemi and Takanori Ueda

    Citation: BMC Cancer 2014 14:547

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  48. Content type: Research article

    Because oestrogen receptor α (ERα) regulates E2F1 expression to mediate tamoxifen resistance in ERα-positive breast cancer cells, we aimed to define the possible roles of ERα and E2F1 in promoting the resistan...

    Authors: María F Montenegro, María del Mar Collado-González, María Piedad Fernández-Pérez, Manel B Hammouda, Lana Tolordava, Mariam Gamkrelidze and José Neptuno Rodríguez-López

    Citation: BMC Cancer 2014 14:539

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  49. Content type: Research article

    Ionizing radiation (IR) is a mainstay of cancer therapy, but irradiation can at times also lead to stress responses, which counteract IR-induced cytotoxicity. IR also triggers cellular secretion of vascular en...

    Authors: Colette J Shen, Ashish Sharma, Dinh-Van Vuong, Janine T Erler, Martin Pruschy and Angela Broggini-Tenzer

    Citation: BMC Cancer 2014 14:532

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  50. Content type: Research article

    Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here...

    Authors: Maamoun Fatfat, Raghida Abou Merhi, Omar Rahal, Detcho A Stoyanovsky, Angela Zaki, Hazar Haidar, Valerian E Kagan, Hala Gali-Muhtasib and Khaled Machaca

    Citation: BMC Cancer 2014 14:527

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