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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 7 of 10

  1. Content type: Research article

    We investigated the role of the HIPK2–p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments.

    Authors: Lihong Zhou, Yuanyuan Feng, Yongjie Jin, Xuan Liu, Hua Sui, Ni Chai, Xingzhu Chen, Ningning Liu, Qing Ji, Yan Wang and Qi Li

    Citation: BMC Cancer 2014 14:747

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  2. Content type: Research article

    The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea and Lorenza Díaz

    Citation: BMC Cancer 2014 14:745

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  3. Content type: Research article

    Castration resistant prostate cancer (CRPC) is a leading cause of cancer-related deaths in men. The primary cause of mortality and morbidity in patients is bone metastases and remodeling resulting in osteoblas...

    Authors: Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li

    Citation: BMC Cancer 2014 14:742

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  4. Content type: Research article

    The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might...

    Authors: Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin and Jun Peng

    Citation: BMC Cancer 2014 14:729

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  5. Content type: Research article

    Pancreatic cancer is frequently resistant to cancer therapeutics. Smoking and alcoholism are risk factors and pancreatic cancer patients often undergo nicotine replacement therapy (NRT) and treatment for alcoh...

    Authors: Jheelam Banerjee, Hussein AN Al-Wadei, Mohammed H Al-Wadei, Koami Dagnon and Hildegard M Schuller

    Citation: BMC Cancer 2014 14:725

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  6. Content type: Research article

    Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causes a mixed or hybrid form of concurrent a...

    Authors: Dongdong Chen, Mingke Song, Osama Mohamad and Shan Ping Yu

    Citation: BMC Cancer 2014 14:716

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  7. Content type: Research article

    Transduction of human mesenchymal stem cells (MSCs) with type 5 adenoviruses (Ad5) is limited in the efficacy because of the poor expression level of the coxsackie adenovirus receptor (CAR) molecules. We exami...

    Authors: Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi and Masatoshi Tagawa

    Citation: BMC Cancer 2014 14:713

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  8. Content type: Research article

    Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research ...

    Authors: Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan and Weidong Zhang

    Citation: BMC Cancer 2014 14:689

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  9. Content type: Research article

    Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, an...

    Authors: Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu and Qingyong Ma

    Citation: BMC Cancer 2014 14:686

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  10. Content type: Research article

    Crizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). To evaluate the effica...

    Authors: Haili Qian, Feng Gao, Haijuan Wang and Fei Ma

    Citation: BMC Cancer 2014 14:683

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  11. Content type: Research article

    Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR b...

    Authors: Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray and Francis J Hornicek

    Citation: BMC Cancer 2014 14:681

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  12. Content type: Research article

    Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodr...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan and William L Stone

    Citation: BMC Cancer 2014 14:675

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  13. Content type: Research article

    Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Here, we reported the effect of AChE on gastric cancer therapy.

    Authors: Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu and Liang Chu

    Citation: BMC Cancer 2014 14:668

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  14. Content type: Research article

    Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis....

    Authors: Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles and James A Thomson

    Citation: BMC Cancer 2014 14:621

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  15. Content type: Research article

    Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients’ quality of life, yet effecti...

    Authors: Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont and Stanley K Liu

    Citation: BMC Cancer 2014 14:614

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  16. Content type: Research article

    Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed. Targeting DNA repair pathways to sensitize tumor cells to chemo- or radiotherapy is under inve...

    Authors: Clément Guillot, Vincent Favaudon, Zdenko Herceg, Charlotte Sagne, Sylvie Sauvaigo, Philippe Merle, Janet Hall and Isabelle Chemin

    Citation: BMC Cancer 2014 14:603

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  17. Content type: Research article

    Despite advances in the treatment of primary breast tumors, the outcome of metastatic breast cancer remains dismal. Brain metastases present a particularly difficult therapeutic target due to the “sanctuary” s...

    Authors: Yuriy Shapovalov, Martha Zettel, Sara C Spielman, Stacy A Amico-Ruvio, Emily A Kelly, Grayson O Sipe, Ian M Dickerson, Ania K Majewska and Edward B Brown

    Citation: BMC Cancer 2014 14:598

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  18. Content type: Research article

    The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAI...

    Authors: Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen and Moul Dey

    Citation: BMC Cancer 2014 14:591

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  19. Content type: Research article

    A specific targeting modality for hepatocellular carcinoma (HCC) could ideally encompass a liver cell specific delivery system of a transcriptional unit that is active only in neoplastic cells. Sendai virosome...

    Authors: Mohammad Khalid Zakaria, Imran Khan, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha

    Citation: BMC Cancer 2014 14:582

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  20. Content type: Research article

    Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers with underlying DNA repair, DN...

    Authors: Christopher Bryant, Rebecca Rawlinson and Andrew J Massey

    Citation: BMC Cancer 2014 14:570

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  21. Content type: Research article

    Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-in...

    Authors: Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya and Siddhartha Sankar Jana

    Citation: BMC Cancer 2014 14:567

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  22. Content type: Research article

    We previously reported that 3'-ethynylcytidine (ECyd, TAS-106), an RNA polymerases inhibitor, enhances the anti-tumor efficacy of platinum in several tumor types in both in vitro and in vivo tumor models. However...

    Authors: Hiroto Fukushima, Tetsuya Abe, Kazuki Sakamoto, Hiroaki Tsujimoto, Shinji Mizuarai and Shinji Oie

    Citation: BMC Cancer 2014 14:562

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  23. Content type: Research article

    Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular activ...

    Authors: Takahiro Yamauchi, Kanako Uzui, Rie Nishi, Hiroko Shigemi and Takanori Ueda

    Citation: BMC Cancer 2014 14:547

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  24. Content type: Research article

    Because oestrogen receptor α (ERα) regulates E2F1 expression to mediate tamoxifen resistance in ERα-positive breast cancer cells, we aimed to define the possible roles of ERα and E2F1 in promoting the resistan...

    Authors: María F Montenegro, María del Mar Collado-González, María Piedad Fernández-Pérez, Manel B Hammouda, Lana Tolordava, Mariam Gamkrelidze and José Neptuno Rodríguez-López

    Citation: BMC Cancer 2014 14:539

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  25. Content type: Research article

    Ionizing radiation (IR) is a mainstay of cancer therapy, but irradiation can at times also lead to stress responses, which counteract IR-induced cytotoxicity. IR also triggers cellular secretion of vascular en...

    Authors: Colette J Shen, Ashish Sharma, Dinh-Van Vuong, Janine T Erler, Martin Pruschy and Angela Broggini-Tenzer

    Citation: BMC Cancer 2014 14:532

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  26. Content type: Research article

    Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here...

    Authors: Maamoun Fatfat, Raghida Abou Merhi, Omar Rahal, Detcho A Stoyanovsky, Angela Zaki, Hazar Haidar, Valerian E Kagan, Hala Gali-Muhtasib and Khaled Machaca

    Citation: BMC Cancer 2014 14:527

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  27. Content type: Research article

    Chk1 inhibitors are currently in clinical trials in combination with a range of cytotoxic agents and have the potential to potentiate the clinical activity of a large number of standard of care chemotherapeuti...

    Authors: Rebecca Rawlinson and Andrew J Massey

    Citation: BMC Cancer 2014 14:483

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  28. Content type: Research article

    The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery ...

    Authors: Anna Zajakina, Jelena Vasilevska, Dmitry Zhulenkovs, Dace Skrastina, Artjoms Spaks, Aiva Plotniece and Tatjana Kozlovska

    Citation: BMC Cancer 2014 14:460

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  29. Content type: Research article

    Clear cell sarcoma (CCS) is a therapeutically unresolved, aggressive, soft tissue sarcoma (STS) that predominantly affects young adults. This sarcoma is defined by t(12;22)(q13;q12) translocation, which leads ...

    Authors: Hidetatsu Outani, Takaaki Tanaka, Toru Wakamatsu, Yoshinori Imura, Kenichiro Hamada, Nobuhito Araki, Kazuyuki Itoh, Hideki Yoshikawa and Norifumi Naka

    Citation: BMC Cancer 2014 14:455

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  30. Content type: Research article

    Glioblastomas are largely unresponsive to all available treatments and there is therefore an urgent need for novel therapeutics. Here we have probed the antineoplastic effects of a bacterial protein toxin, the...

    Authors: Eleonora Vannini, Anna Panighini, Chiara Cerri, Alessia Fabbri, Simonetta Lisi, Enrico Pracucci, Nicola Benedetto, Riccardo Vannozzi, Carla Fiorentini, Matteo Caleo and Mario Costa

    Citation: BMC Cancer 2014 14:449

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  31. Content type: Research article

    The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells.

    Authors: Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot and Catherine Pellat-Deceunynck

    Citation: BMC Cancer 2014 14:437

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  32. Content type: Research article

    A common approach to cancer therapy in clinical practice is the combination of several drugs to boost the anticancer activity of available drugs while suppressing their unwanted side effects. In this regard, w...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim, Da-Eun Jo, Soo-Ah Park, Pann-Ghill Suh and Byoung Heon Kang

    Citation: BMC Cancer 2014 14:431

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  33. Content type: Research article

    Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations ofte...

    Authors: William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse and Jieyi Wang

    Citation: BMC Cancer 2014 14:430

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  34. Content type: Research article

    Breast cancer is one of the most deadly diseases in women. Inhibiting the synthesis of estrogen is effective in treating patients with estrogen-responsive breast cancer. Previous studies have demonstrated that...

    Authors: Tsz Yan Wong, Fengjuan Li, Shu-mei Lin, Franky L Chan, Shiuan Chen and Lai K Leung

    Citation: BMC Cancer 2014 14:426

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  35. Content type: Research article

    Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression ...

    Authors: Hideyuki Abe, Takao Kamai, Keitaro Hayashi, Naohiko Anzai, Hiromichi Shirataki, Tomoya Mizuno, Yoshiyuki Yamaguchi, Akinori Masuda, Hideo Yuki, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2014 14:412

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  36. Content type: Research article

    Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to eva...

    Authors: Sara Marinelli, Veronica Salvatore, Marco Baron Toaldo, Maddalena Milazzo, Luca Croci, Laura Venerandi, Anna Pecorelli, Chiara Palamà, Alessia Diana, Luigi Bolondi and Fabio Piscaglia

    Citation: BMC Cancer 2014 14:403

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  37. Content type: Research article

    Photoimmunotherapy (PIT) is a highly cell-selective cancer therapy, which employs monoclonal antibodies conjugated to a potent photosensitizer (mAb-IR700). Once the conjugate has bound to the target cell, expo...

    Authors: Takahito Nakajima, Kazuhide Sato, Hirofumi Hanaoka, Rira Watanabe, Toshiko Harada, Peter L Choyke and Hisataka Kobayashi

    Citation: BMC Cancer 2014 14:389

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  38. Content type: Research article

    Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent.

    Authors: Xing-dong Xu, Lan Yang, Li-yun Zheng, Yan-yan Pan, Zhi-fei Cao, Zhi-qing Zhang, Quan-sheng Zhou, Bo Yang and Cong Cao

    Citation: BMC Cancer 2014 14:373

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    The Erratum to this article has been published in BMC Cancer 2016 16:374

  39. Content type: Research article

    Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of the natural killer group 2D (NKG2D) ligands on tumor cells; however, the m...

    Authors: Pengfei Shi, Tao Yin, Feng Zhou, Pengfei Cui, Shanmiao Gou and Chunyou Wang

    Citation: BMC Cancer 2014 14:370

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  40. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Since HCC has been shown to be immunogenic, immunotherapy is considered a promising therapeutic...

    Authors: Tatyana O Kabilova, Larisa V Kovtonyuk, Evgeniy V Zonov, Elena I Ryabchikova, Nelly A Popova, Valeriy P Nikolin, Vasiliy I Kaledin, Marina A Zenkova, Valentin V Vlassov and Elena L Chernolovskaya

    Citation: BMC Cancer 2014 14:338

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  41. Content type: Research article

    The small size of ultra-small nanoparticles makes them suitable for lymphatic delivery, and many recent studies have examined their role in anti-metastasis therapy. However, the anti-metastatic efficacy of sma...

    Authors: Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia and Zhonggao Gao

    Citation: BMC Cancer 2014 14:329

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  42. Content type: Research article

    Oesophageal squamous cell carcinoma (OSCC) is a highly aggressive carcinoma with a poor survival rate. One of the most commonly used chemotherapeutic drugs, cisplatin, displays varied and often poor efficacy i...

    Authors: Leonard Howard Damelin, Rupal Jivan, Robin Bruce Veale, Amanda Louise Rousseau and Demetra Mavri-Damelin

    Citation: BMC Cancer 2014 14:314

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  43. Content type: Research article

    Androgen deprivation therapy is the primary strategy for the treatment of advanced prostate cancer; however, after an initial regression, most patients will inevitably develop a fatal androgen-independent tumo...

    Authors: Xiaolu Wang, Haitao Gao, Lixin Ren, Junfei Gu, Yanping Zhang and Yong Zhang

    Citation: BMC Cancer 2014 14:308

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  44. Content type: Review

    Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeuti...

    Authors: Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti and Diego Russo

    Citation: BMC Cancer 2014 14:303

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  45. Content type: Research article

    Surgical therapies are the first-line treatments for hepatocellular carcinoma (HCC) patients. However, the high incidence of tumor metastasis after liver surgery remains a severe problem. We aim to investigate...

    Authors: Chang Xian Li, Bing L Wong, Chang Chun Ling, Yuen Yuen Ma, Yan Shao, Wei Geng, Xiang Qi, Sze Hang Lau, Sui Yi Kwok, Na Wei, Fei Chuen Tzang, Kevin TP Ng, Xiao Bing Liu, Chung Mau Lo and Kwan Man

    Citation: BMC Cancer 2014 14:293

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  46. Content type: Research article

    Zalypsis® is a marine compound in phase II clinical trials for multiple myeloma, cervical and endometrial cancer, and Ewing’s sarcoma. However, the determinants of the response to Zalypsis are not well known. ...

    Authors: Victoria Moneo, Beatriz G Serelde, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Pablo Avilés, Gemma Santamaría, Juan C Tercero, Carmen Cuevas and Amancio Carnero

    Citation: BMC Cancer 2014 14:281

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  47. Content type: Research article

    Cholangiocarcinoma (CCA), a devastating neoplasm, is highly resistant to current chemotherapies. CCA cells frequently overexpress the antiapoptotic protein myeloid cell leukemia-1(Mcl-1), which is responsible ...

    Authors: Xiwei Ding, Bin Zhang, Qingshan Pei, Jianmei Pan, Shuling Huang, Yan Yang, Zhu Zhu, Ying Lv and Xiaoping Zou

    Citation: BMC Cancer 2014 14:271

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  48. Content type: Research article

    Gallbladder cancer is the most frequent malignancy of the bile duct with high aggressive and extremely poor prognosis. The main objective of the paper was to investigate the inhibitory effects of oridonin, a d...

    Authors: Runfa Bao, Yijun Shu, Xiangsong Wu, Hao Weng, Qian Ding, Yang Cao, Maolan Li, Jiasheng Mu, Wenguang Wu, Qichen Ding, Zhujun Tan, Tianyu Liu, Lin Jiang, Yunping Hu, Jianfeng Gu and Yingbin Liu

    Citation: BMC Cancer 2014 14:217

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