Skip to main content

Advertisement

Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 7 of 11

  1. The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3%. Temozolomide (TMZ) remains the standard first-line treatment regimen for...

    Authors: Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham and Paula YP Lam

    Citation: BMC Cancer 2015 15:255

    Content type: Research article

    Published on:

  2. To overcome the limitations of animal-based experiments, 3D culture models mimicking the tumor microenvironment in vivo are gaining attention. Herein, we investigated an alginate-based 3D scaffold for screening o...

    Authors: Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel and Constanze Buhrmann

    Citation: BMC Cancer 2015 15:250

    Content type: Research article

    Published on:

  3. Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targe...

    Authors: Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin and Jingxuan Pan

    Citation: BMC Cancer 2015 15:226

    Content type: Research article

    Published on:

  4. Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constituti...

    Authors: Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras and Adela Mazo

    Citation: BMC Cancer 2015 15:223

    Content type: Research article

    Published on:

  5. Treatment failure is a critical issue in breast cancer and identifying useful interventions that optimize current cancer therapies remains a critical unmet need. Expression and functional studies have identifi...

    Authors: Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar and Elizabeth S Yeh

    Citation: BMC Cancer 2015 15:296

    Content type: Research article

    Published on:

  6. Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due t...

    Authors: Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu and Wenzhi Tian

    Citation: BMC Cancer 2015 15:170

    Content type: Research article

    Published on:

  7. High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key act...

    Authors: Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang and Qibing Zhou

    Citation: BMC Cancer 2015 15:159

    Content type: Research article

    Published on:

  8. Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and indu...

    Authors: Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao and Li-Shun Wang

    Citation: BMC Cancer 2015 15:139

    Content type: Research article

    Published on:

  9. Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEU...

    Authors: Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li and Jian-hua Zhou

    Citation: BMC Cancer 2015 15:136

    Content type: Research article

    Published on:

  10. Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in vitro and mouse models have characterized the role of ce...

    Authors: Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett and Mark Basik

    Citation: BMC Cancer 2015 15:130

    Content type: Research article

    Published on:

  11. Triple-negative breast cancer (TNBC) shows aggressive clinical behavior, but the treatment options are limited due to lack of a specific target. TNBC shares many clinical and pathological similarities with BRC...

    Authors: Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie and In Ah Kim

    Citation: BMC Cancer 2015 15:89

    Content type: Research article

    Published on:

  12. Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki

    Citation: BMC Cancer 2015 15:82

    Content type: Research article

    Published on:

  13. Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in p...

    Authors: Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler and Sven Arke Lang

    Citation: BMC Cancer 2015 15:71

    Content type: Research article

    Published on:

  14. Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) act...

    Authors: Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez

    Citation: BMC Cancer 2015 15:34

    Content type: Research article

    Published on:

  15. Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. How...

    Authors: Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez

    Citation: BMC Cancer 2015 15:21

    Content type: Research article

    Published on:

  16. Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...

    Authors: Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong and Kyung Seok Han

    Citation: BMC Cancer 2015 15:19

    Content type: Research article

    Published on:

  17. DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli

    Citation: BMC Cancer 2015 15:17

    Content type: Research article

    Published on:

  18. Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai

    Citation: BMC Cancer 2014 14:987

    Content type: Research article

    Published on:

  19. Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recu...

    Authors: Andrea Khong, Amanda L Cleaver, Muhammad Fahmi Alatas, Ben C Wylie, Theresa Connor, Scott A Fisher, Steve Broomfield, Willem J Lesterhuis, Andrew J Currie, Richard A Lake and Bruce W Robinson

    Citation: BMC Cancer 2014 14:969

    Content type: Research article

    Published on:

  20. Inhibition of metastasis through upregulation of immune surveillance is a major purpose of chemokine gene therapy. In this study, we focused on a membrane-bound chemokine CXCL16, which has shown a correlation ...

    Authors: Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Koichi Tsuneyama, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Ichiro Takasaki, Akiko Inujima, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi

    Citation: BMC Cancer 2014 14:949

    Content type: Research article

    Published on:

  21. Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone

    Citation: BMC Cancer 2014 14:918

    Content type: Research article

    Published on:

  22. The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes

    Citation: BMC Cancer 2014 14:916

    Content type: Research article

    Published on:

  23. The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour mode...

    Authors: Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen and Michael R Horsman

    Citation: BMC Cancer 2014 14:903

    Content type: Research article

    Published on:

  24. A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan

    Citation: BMC Cancer 2014 14:889

    Content type: Research article

    Published on:

  25. Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell in...

    Authors: Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh and Takuya Matsunaga

    Citation: BMC Cancer 2014 14:882

    Content type: Research article

    Published on:

  26. The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we...

    Authors: John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli and Per Sunnerhagen

    Citation: BMC Cancer 2014 14:853

    Content type: Research article

    Published on:

  27. The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer respon...

    Authors: Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust and Leszek Wojnowski

    Citation: BMC Cancer 2014 14:842

    Content type: Research article

    Published on:

  28. Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. New treatment options for the disease are needed. In this study, we identified and evaluated tumor vascular PLVAP as a therapeutic tar...

    Authors: Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang and Kuo-Jang Kao

    Citation: BMC Cancer 2014 14:815

    Content type: Research article

    Published on:

  29. Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...

    Authors: Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran

    Citation: BMC Cancer 2014 14:800

    Content type: Research article

    Published on:

  30. Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell l...

    Authors: Zhaoyang Lu, Jiabei Wang, Tongsen Zheng, Yingjian Liang, Dalong Yin, Ruipeng Song, Tiemin Pei, Shangha Pan, Hongchi Jiang and Lianxin Liu

    Citation: BMC Cancer 2014 14:783

    Content type: Research article

    Published on:

  31. Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bac...

    Authors: Jaspreet Kaur Dhanjal, Nupur Nigam, Sudhanshu Sharma, Anupama Chaudhary, Sunil C Kaul, Abhinav Grover and Renu Wadhwa

    Citation: BMC Cancer 2014 14:775

    Content type: Research article

    Published on:

  32. Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with s...

    Authors: Jing Wang, Song Gu, Jun Huang, Sheng Chen, Zhen Zhang and Min Xu

    Citation: BMC Cancer 2014 14:768

    Content type: Research article

    Published on:

  33. Atorvastatin is a potent inhibitor of the mevalonate pathway and widely used as a hypolipidemic drug. Some epidemiological studies and animal experiments indicate that the long-term use of atorvastatin and str...

    Authors: Albert Braeuning, Philip Bucher, Ute Hofmann, Albrecht Buchmann and Michael Schwarz

    Citation: BMC Cancer 2014 14:766

    Content type: Research article

    Published on:

  34. Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, s...

    Authors: Robert J Canter, Erik Ames, Stephanie Mac, Steven K Grossenbacher, Mingyi Chen, Chin-Shang Li, Dariusz Borys, Rachel C Smith, Joe Tellez, Thomas J Sayers, Arta M Monjazeb and William J Murphy

    Citation: BMC Cancer 2014 14:756

    Content type: Research article

    Published on:

  35. Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented ...

    Authors: Emily R Theisen, Snehal Gajiwala, Jared Bearss, Venkataswamy Sorna, Sunil Sharma and Margit Janat-Amsbury

    Citation: BMC Cancer 2014 14:752

    Content type: Research article

    Published on:

  36. We investigated the role of the HIPK2–p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments.

    Authors: Lihong Zhou, Yuanyuan Feng, Yongjie Jin, Xuan Liu, Hua Sui, Ni Chai, Xingzhu Chen, Ningning Liu, Qing Ji, Yan Wang and Qi Li

    Citation: BMC Cancer 2014 14:747

    Content type: Research article

    Published on:

  37. The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea and Lorenza Díaz

    Citation: BMC Cancer 2014 14:745

    Content type: Research article

    Published on:

  38. Castration resistant prostate cancer (CRPC) is a leading cause of cancer-related deaths in men. The primary cause of mortality and morbidity in patients is bone metastases and remodeling resulting in osteoblas...

    Authors: Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li

    Citation: BMC Cancer 2014 14:742

    Content type: Research article

    Published on:

  39. The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might...

    Authors: Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin and Jun Peng

    Citation: BMC Cancer 2014 14:729

    Content type: Research article

    Published on:

  40. Pancreatic cancer is frequently resistant to cancer therapeutics. Smoking and alcoholism are risk factors and pancreatic cancer patients often undergo nicotine replacement therapy (NRT) and treatment for alcoh...

    Authors: Jheelam Banerjee, Hussein AN Al-Wadei, Mohammed H Al-Wadei, Koami Dagnon and Hildegard M Schuller

    Citation: BMC Cancer 2014 14:725

    Content type: Research article

    Published on:

  41. Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causes a mixed or hybrid form of concurrent a...

    Authors: Dongdong Chen, Mingke Song, Osama Mohamad and Shan Ping Yu

    Citation: BMC Cancer 2014 14:716

    Content type: Research article

    Published on:

  42. Transduction of human mesenchymal stem cells (MSCs) with type 5 adenoviruses (Ad5) is limited in the efficacy because of the poor expression level of the coxsackie adenovirus receptor (CAR) molecules. We exami...

    Authors: Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi and Masatoshi Tagawa

    Citation: BMC Cancer 2014 14:713

    Content type: Research article

    Published on:

  43. Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research ...

    Authors: Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan and Weidong Zhang

    Citation: BMC Cancer 2014 14:689

    Content type: Research article

    Published on:

  44. Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, an...

    Authors: Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu and Qingyong Ma

    Citation: BMC Cancer 2014 14:686

    Content type: Research article

    Published on:

  45. Crizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). To evaluate the effica...

    Authors: Haili Qian, Feng Gao, Haijuan Wang and Fei Ma

    Citation: BMC Cancer 2014 14:683

    Content type: Research article

    Published on:

  46. Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR b...

    Authors: Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray and Francis J Hornicek

    Citation: BMC Cancer 2014 14:681

    Content type: Research article

    Published on:

  47. Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodr...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan and William L Stone

    Citation: BMC Cancer 2014 14:675

    Content type: Research article

    Published on:

  48. Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Here, we reported the effect of AChE on gastric cancer therapy.

    Authors: Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu and Liang Chu

    Citation: BMC Cancer 2014 14:668

    Content type: Research article

    Published on: