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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 6 of 10

  1. Content type: Research article

    Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed ...

    Authors: Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis and Eileen K. Jaffe

    Citation: BMC Cancer 2015 15:436

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  2. Content type: Research article

    The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explore...

    Authors: Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci and Charles P Hart

    Citation: BMC Cancer 2015 15:422

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  3. Content type: Research article

    Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed.

    Authors: Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang and Stine Falsig Pedersen

    Citation: BMC Cancer 2015 15:411

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  4. Content type: Research article

    Cancer-specific survival has changed remarkably little over the past half century, mainly because metastases that are occult at diagnosis and generally resistant to chemotherapy subsequently develop months, ye...

    Authors: Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon and Michael A. Ihnat

    Citation: BMC Cancer 2015 15:404

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  5. Content type: Research article

    Accumulating evidence suggests that breast cancer involves tumour-initiating cells (TICs), which play a role in initiation, metastasis, therapeutic resistance and relapse of the disease. Emerging drugs that ta...

    Authors: Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong and Jiri Neuzil

    Citation: BMC Cancer 2015 15:401

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  6. Content type: Technical advance

    The monocarboxylate transporter-1 (MCT1) represents a novel target in rational anticancer drug design while AZD3965 was developed as an inhibitor of this transporter and is undergoing Phase I clinical trials (

    Authors: Stephen Kershaw, Jeffrey Cummings, Karen Morris, Jonathan Tugwood and Caroline Dive

    Citation: BMC Cancer 2015 15:387

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  7. Content type: Research article

    To evaluate the in vivo response by detecting the anti-angiogenic and invasion-inhibiting effects of a triple-combination-therapy in an experimental-small-animal-squamous-cell-carcinoma-model using the “flash-...

    Authors: Philipp Marius Paprottka, Svenja Roßpunt, Michael Ingrisch, Clemens C Cyran, Konstantin Nikolaou, Maximilian F Reiser, Brigitte Mack, Olivier Gires, Dirk A Clevert and Pamela Zengel

    Citation: BMC Cancer 2015 15:373

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  8. Content type: Research article

    Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel a...

    Authors: Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao and Zhenyu Jia

    Citation: BMC Cancer 2015 15:325

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  9. Content type: Research article

    5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats a...

    Authors: Chen-Hsi Hsieh, Mei-Ling Hou, Li-Ying Wang, Hung-Chi Tai, Tung-Hu Tsai and Yu-Jen Chen

    Citation: BMC Cancer 2015 15:316

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  10. Content type: Research article

    Natural Killer (NK) cells play an important role in tumor prevention, but once tumors form, the numbers as well as the cytotoxic functions of NK cells are reduced. IL-15 is a cytokine that increases and activa...

    Authors: Amy E Gillgrass, Marianne V Chew, Tamara Krneta and Ali A Ashkar

    Citation: BMC Cancer 2015 15:293

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  11. Content type: Research article

    Breast cancer is a complex heterogeneous disease and is one of the leading causes of death among women. In addressing the need for treatments of this life-threatening illness, we studied 3,4-dihydropyrimidin-2...

    Authors: Bruna C Guido, Luciana M Ramos, Diego O Nolasco, Catharine C Nobrega, Bárbara YG Andrade, Aline Pic-Taylor, Brenno AD Neto and José R Corrêa

    Citation: BMC Cancer 2015 15:283

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  12. Content type: Research article

    Fibroblast growth factor receptor 1 (FGFR1) is correlated closely with the occurrence and development of lung cancer. FGFR1 kinase inhibitors have exhibited significant therapeutic effects against non-small-ce...

    Authors: Jianzhang Wu, Tao Wei, Qinqin Tang, Bixia Weng, Wulan Li, Xin Jiang, Ting Ding, Xiaokun Li, Guang Liang, Yuepiao Cai and Jiansong Ji

    Citation: BMC Cancer 2015 15:276

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  13. Content type: Research article

    Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows pheno...

    Authors: Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shirota, Taro Yamashita, Ichinosuke Hyodo and Yukio Nakamura

    Citation: BMC Cancer 2015 15:260

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  14. Content type: Research article

    The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3%. Temozolomide (TMZ) remains the standard first-line treatment regimen for...

    Authors: Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham and Paula YP Lam

    Citation: BMC Cancer 2015 15:255

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  15. Content type: Research article

    To overcome the limitations of animal-based experiments, 3D culture models mimicking the tumor microenvironment in vivo are gaining attention. Herein, we investigated an alginate-based 3D scaffold for screening o...

    Authors: Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel and Constanze Buhrmann

    Citation: BMC Cancer 2015 15:250

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  16. Content type: Research article

    Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targe...

    Authors: Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin and Jingxuan Pan

    Citation: BMC Cancer 2015 15:226

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  17. Content type: Research article

    Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constituti...

    Authors: Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras and Adela Mazo

    Citation: BMC Cancer 2015 15:223

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  18. Content type: Research article

    Treatment failure is a critical issue in breast cancer and identifying useful interventions that optimize current cancer therapies remains a critical unmet need. Expression and functional studies have identifi...

    Authors: Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar and Elizabeth S Yeh

    Citation: BMC Cancer 2015 15:296

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  19. Content type: Research article

    Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due t...

    Authors: Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu and Wenzhi Tian

    Citation: BMC Cancer 2015 15:170

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  20. Content type: Research article

    High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key act...

    Authors: Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang and Qibing Zhou

    Citation: BMC Cancer 2015 15:159

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  21. Content type: Research article

    Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and indu...

    Authors: Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao and Li-Shun Wang

    Citation: BMC Cancer 2015 15:139

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  22. Content type: Research article

    Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEU...

    Authors: Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li and Jian-hua Zhou

    Citation: BMC Cancer 2015 15:136

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  23. Content type: Research article

    Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in vitro and mouse models have characterized the role of ce...

    Authors: Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett and Mark Basik

    Citation: BMC Cancer 2015 15:130

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  24. Content type: Research article

    Triple-negative breast cancer (TNBC) shows aggressive clinical behavior, but the treatment options are limited due to lack of a specific target. TNBC shares many clinical and pathological similarities with BRC...

    Authors: Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie and In Ah Kim

    Citation: BMC Cancer 2015 15:89

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  25. Content type: Research article

    Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki

    Citation: BMC Cancer 2015 15:82

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  26. Content type: Research article

    Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in p...

    Authors: Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler and Sven Arke Lang

    Citation: BMC Cancer 2015 15:71

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  27. Content type: Research article

    Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) act...

    Authors: Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez

    Citation: BMC Cancer 2015 15:34

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  28. Content type: Research article

    Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. How...

    Authors: Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez

    Citation: BMC Cancer 2015 15:21

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  29. Content type: Research article

    Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...

    Authors: Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong and Kyung Seok Han

    Citation: BMC Cancer 2015 15:19

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  30. Content type: Research article

    DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli

    Citation: BMC Cancer 2015 15:17

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  31. Content type: Research article

    Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai

    Citation: BMC Cancer 2014 14:987

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  32. Content type: Research article

    Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recu...

    Authors: Andrea Khong, Amanda L Cleaver, Muhammad Fahmi Alatas, Ben C Wylie, Theresa Connor, Scott A Fisher, Steve Broomfield, Willem J Lesterhuis, Andrew J Currie, Richard A Lake and Bruce W Robinson

    Citation: BMC Cancer 2014 14:969

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  33. Content type: Research article

    Inhibition of metastasis through upregulation of immune surveillance is a major purpose of chemokine gene therapy. In this study, we focused on a membrane-bound chemokine CXCL16, which has shown a correlation ...

    Authors: Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Koichi Tsuneyama, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Ichiro Takasaki, Akiko Inujima, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi

    Citation: BMC Cancer 2014 14:949

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  34. Content type: Research article

    Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone

    Citation: BMC Cancer 2014 14:918

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  35. Content type: Research article

    The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes

    Citation: BMC Cancer 2014 14:916

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  36. Content type: Research article

    The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour mode...

    Authors: Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen and Michael R Horsman

    Citation: BMC Cancer 2014 14:903

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  37. Content type: Research article

    A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan

    Citation: BMC Cancer 2014 14:889

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  38. Content type: Research article

    Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell in...

    Authors: Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh and Takuya Matsunaga

    Citation: BMC Cancer 2014 14:882

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  39. Content type: Research article

    The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we...

    Authors: John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli and Per Sunnerhagen

    Citation: BMC Cancer 2014 14:853

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  40. Content type: Research article

    The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer respon...

    Authors: Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust and Leszek Wojnowski

    Citation: BMC Cancer 2014 14:842

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  41. Content type: Research article

    Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. New treatment options for the disease are needed. In this study, we identified and evaluated tumor vascular PLVAP as a therapeutic tar...

    Authors: Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang and Kuo-Jang Kao

    Citation: BMC Cancer 2014 14:815

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  42. Content type: Research article

    Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...

    Authors: Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran

    Citation: BMC Cancer 2014 14:800

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  43. Content type: Research article

    Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell l...

    Authors: Zhaoyang Lu, Jiabei Wang, Tongsen Zheng, Yingjian Liang, Dalong Yin, Ruipeng Song, Tiemin Pei, Shangha Pan, Hongchi Jiang and Lianxin Liu

    Citation: BMC Cancer 2014 14:783

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  44. Content type: Research article

    Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bac...

    Authors: Jaspreet Kaur Dhanjal, Nupur Nigam, Sudhanshu Sharma, Anupama Chaudhary, Sunil C Kaul, Abhinav Grover and Renu Wadhwa

    Citation: BMC Cancer 2014 14:775

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  45. Content type: Research article

    Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with s...

    Authors: Jing Wang, Song Gu, Jun Huang, Sheng Chen, Zhen Zhang and Min Xu

    Citation: BMC Cancer 2014 14:768

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  46. Content type: Research article

    Atorvastatin is a potent inhibitor of the mevalonate pathway and widely used as a hypolipidemic drug. Some epidemiological studies and animal experiments indicate that the long-term use of atorvastatin and str...

    Authors: Albert Braeuning, Philip Bucher, Ute Hofmann, Albrecht Buchmann and Michael Schwarz

    Citation: BMC Cancer 2014 14:766

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  47. Content type: Research article

    Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, s...

    Authors: Robert J Canter, Erik Ames, Stephanie Mac, Steven K Grossenbacher, Mingyi Chen, Chin-Shang Li, Dariusz Borys, Rachel C Smith, Joe Tellez, Thomas J Sayers, Arta M Monjazeb and William J Murphy

    Citation: BMC Cancer 2014 14:756

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  48. Content type: Research article

    Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented ...

    Authors: Emily R Theisen, Snehal Gajiwala, Jared Bearss, Venkataswamy Sorna, Sunil Sharma and Margit Janat-Amsbury

    Citation: BMC Cancer 2014 14:752

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