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BMC Cancer

Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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  1. Content type: Research article

    Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c.

    Authors: Don W. Coulter, Timothy R. McGuire, John G. Sharp, Erin M. McIntyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram S. Joshi, Xiaoyu Chen and Jonathan L. Vennerstrom

    Citation: BMC Cancer 2016 16:867

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  2. Content type: Research article

    Vorinostat, a histone deacetylase (HDAC) inhibitor, is a promising agent for cancer therapy. Combining vorinostat with cisplatin may relax the chromatin structure and facilitate the accessibility of cisplatin,...

    Authors: Chun-Hao Pan, Ying-Fang Chang, Ming-Shuo Lee, B-Chen Wen, Jen-Chung Ko, Sheng-Kai Liang and Mei-Chih Liang

    Citation: BMC Cancer 2016 16:857

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  3. Content type: Research article

    Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression of hairy and enhancer of split 1 (Hes-1) has not been investigated yet in resected specimens of CC. Notch signaling...

    Authors: Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose and Michiaki Unno

    Citation: BMC Cancer 2016 16:854

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  4. Content type: Research article

    Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing h...

    Authors: Hongxia Ye, Xiaojuan Liu, Jiangchuan Sun, Shenyin Zhu, Yi Zhu and Shufang Chang

    Citation: BMC Cancer 2016 16:831

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  5. Content type: Research article

    Endometrial cancer is the most common cancer of the female reproductive tract.

    Authors: Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski and Kamil Torres

    Citation: BMC Cancer 2016 16:822

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    The Erratum to this article has been published in BMC Cancer 2016 16:939

  6. Content type: Research article

    Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as eff...

    Authors: Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min and Hai-yan Hu

    Citation: BMC Cancer 2016 16:818

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  7. Content type: Research article

    Previous studies have reported that eEF-2 kinase is associated with tumour cell sensitivity to certain therapies. In the present study, we investigated the relationship between eEF-2 kinase and lapatinib, a du...

    Authors: Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin and PeiJian Peng

    Citation: BMC Cancer 2016 16:813

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  8. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide and is associated with substantial mortality. Because HCCs have strong resistance to conventional chemotherapeutic agents, n...

    Authors: Jae-Woo Jang, Yeonhwa Song, Kang Mo Kim, Jin-Sun Kim, Eun Kyung Choi, Joon Kim and Haengran Seo

    Citation: BMC Cancer 2016 16:810

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  9. Content type: Research article

    Cachexia is one of the most important causes of cancer-related death. Supplementation with branched-chain amino acids, particularly leucine, has been used to minimise loss of muscle tissue, although few studie...

    Authors: Laís Rosa Viana, Rafael Canevarolo, Anna Caroline Perina Luiz, Raquel Frias Soares, Camila Lubaczeuski, Ana Carolina de Mattos Zeri and Maria Cristina Cintra Gomes-Marcondes

    Citation: BMC Cancer 2016 16:764

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  10. Content type: Research article

    Curcuminoids of the spice turmeric and their enhanced derivatives have much potential as cancer treatments. They act on a wide variety of biological pathways, including those regulating cell division and circa...

    Authors: Ashapurna Sarma, Vishal P. Sharma, Arindam B. Sarkar, M. Chandra Sekar, Karunakar Samuel and Michael E. Geusz

    Citation: BMC Cancer 2016 16:759

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  11. Content type: Research article

    Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy, nephropathy, and vomiting are dose-limiting factors. Pr...

    Authors: Yoshihiro Seto, Fumiyasu Okazaki, Keiji Horikawa, Jing Zhang, Hitoshi Sasaki and Hideto To

    Citation: BMC Cancer 2016 16:756

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  12. Content type: Research article

    Mutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors can exhibit resistance t...

    Authors: Ruoxi Hong, Fei Ma, Weimin Zhang, Xiying Yu, Qing Li, Yang Luo, Changjun Zhu, Wei Jiang and Binghe Xu

    Citation: BMC Cancer 2016 16:725

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    The Erratum to this article has been published in BMC Cancer 2016 16:925

  13. Content type: Research article

    Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour ...

    Authors: Mary-Clare Cathcart, Zivile Useckaite, Clive Drakeford, Vikki Semik, Joanne Lysaght, Kathy Gately, Kenneth J. O’Byrne and Graham P. Pidgeon

    Citation: BMC Cancer 2016 16:707

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  14. Content type: Research article

    Iron is essential for cell replication, metabolism and growth. Because neoplastic cells have high iron requirements due to their rapid proliferation, iron depletion may be a novel therapeutic strategy for canc...

    Authors: Hirofumi Harima, Seiji Kaino, Taro Takami, Shuhei Shinoda, Toshihiko Matsumoto, Koichi Fujisawa, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida

    Citation: BMC Cancer 2016 16:702

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  15. Content type: Research article

    shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a hig...

    Authors: Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan and Christina M. Annunziata

    Citation: BMC Cancer 2016 16:678

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  16. Content type: Research article

    Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target fo...

    Authors: I. A. Netland, H. E. Førde, L. Sleire, L. Leiss, M. A. Rahman, B. S. Skeie, C. H. Gjerde, P. Ø. Enger and D. Goplen

    Citation: BMC Cancer 2016 16:657

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  17. Content type: Research article

    We report on the results of a phase II clinical trial of Panagen (tablet form of fragmented human DNA preparation) in breast cancer patients (placebo group n = 23, Panagen n = 57). Panagen was administered as an ...

    Authors: Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Potter, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva…

    Citation: BMC Cancer 2016 16:651

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  18. Content type: Research article

    High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the cell death pathway by interfering with caspase activation. SMAC-mimetics are smal...

    Authors: Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa and Alexander Pintzas

    Citation: BMC Cancer 2016 16:624

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  19. Content type: Research article

    Cyclophosphamide (CPA) can activate immunogenic tumor cell death, which induces immune-based tumor ablation and long-term anti-tumor immunity in a syngeneic C57BL/6 (B6) mouse GL261 glioma model when CPA is gi...

    Authors: Junjie Wu, Marie Jordan and David J. Waxman

    Citation: BMC Cancer 2016 16:623

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