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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 4 of 10

  1. Content type: Research article

    Wogonin is an encouraging choice for clinical use owing to its potent anti-tumor and anti-inflammatory effects with the high safety profile. However, wogonin for targeted therapy of lymphoma was not well addre...

    Authors: Xue Wu, Ping Liu, Haijun Zhang, Yuan Li, Jumah Masoud Mohammad Salmani, Fei Wang, Ke Yang, Rong Fu, Zhewei Chen and Baoan Chen

    Citation: BMC Cancer 2017 17:147

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  2. Content type: Research article

    Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study w...

    Authors: Lin Shi, Zhaozhong Xu, Gang Wu, Xiaoting Chen, Yuanyuan Huang, Yanjing Wang, Weiqiang Jiang and Bin Ke

    Citation: BMC Cancer 2017 17:138

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  3. Content type: Research article

    The aim of this study was to determine whether checkpoint kinase 1 inihibitor (CHK1), LY2603618, and gemcitabine prolong overall survival (OS) compared to gemcitabine alone in patients with unresectable pancre...

    Authors: Berta Laquente, Jose Lopez-Martin, Donald Richards, Gerald Illerhaus, David Z. Chang, George Kim, Philip Stella, Dirk Richel, Cezary Szcylik, Stefano Cascinu, G. L. Frassineti, Tudor Ciuleanu, Karla Hurt, Scott Hynes, Ji Lin, Aimee Bence Lin…

    Citation: BMC Cancer 2017 17:137

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  4. Content type: Research article

    Bacterial toxins have evolved to an effective therapeutic option for cancer therapy. The Clostridium perfringens enterotoxin (CPE) is a pore-forming toxin with selective cytotoxicity. The transmembrane tight junc...

    Authors: Jessica Pahle, Lutz Menzel, Nicole Niesler, Dennis Kobelt, Jutta Aumann, Maria Rivera and Wolfgang Walther

    Citation: BMC Cancer 2017 17:129

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  5. Content type: Research article

    Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangio...

    Authors: Yi Li, Jun Li, Yat Ming Woo, Zan Shen, Hong Yao, Yijun Cai, Marie Chia-mi Lin and Wai Sang Poon

    Citation: BMC Cancer 2017 17:126

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  6. Content type: Research article

    Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxi...

    Authors: Laura Marise de Freitas, Rodolfo Bortolozo Serafim, Juliana Ferreira de Sousa, Thaís Fernanda Moreira, Cláudia Tavares dos Santos, Amanda Martins Baviera, Valeria Valente, Christiane Pienna Soares and Carla Raquel Fontana

    Citation: BMC Cancer 2017 17:123

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  7. Content type: Research article

    Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 mo...

    Authors: Zachary C. Gersey, Gregor A. Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M. Walters, Kelechi C. Ohaeto, Ricardo J. Komotar and Regina M. Graham

    Citation: BMC Cancer 2017 17:99

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  8. Content type: Research article

    Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 to 70% in first-line therapy...

    Authors: Sergey A. Dyshlovoy, Ramin Madanchi, Jessica Hauschild, Katharina Otte, Winfried H. Alsdorf, Udo Schumacher, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer and Gunhild von Amsberg

    Citation: BMC Cancer 2017 17:93

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  9. Content type: Research article

    Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is frequently ineffective in patients with advanced dise...

    Authors: Martin McLaughlin, Holly E. Barker, Aadil A. Khan, Malin Pedersen, Magnus Dillon, David C. Mansfield, Radhika Patel, Joan N. Kyula, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting and Kevin J. Harrington

    Citation: BMC Cancer 2017 17:86

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  10. Content type: Research article

    Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemothera...

    Authors: Sridhar Murahari, Aimee L. Jalkanen, Samuel K. Kulp, Ching-Shih Chen, Jaime F. Modiano, Cheryl A. London and William C. Kisseberth

    Citation: BMC Cancer 2017 17:67

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  11. Content type: Research article

    Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated in current study.

    Authors: Peiju Qiu, Siwen Wang, Ming Liu, He Ma, Xuan Zeng, Meng Zhang, Lingling Xu, Yidi Cui, Huixin Xu, Yang Tang, Yanli He and Lijuan Zhang

    Citation: BMC Cancer 2017 17:55

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  12. Content type: Research article

    Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promisi...

    Authors: Maria Laura Pati, John R. Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer, Carmen Abate and William Hawkins

    Citation: BMC Cancer 2017 17:51

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  13. Content type: Research article

    Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of...

    Authors: Vijayalakshmi N. Ayyagari, Tsung-han Jeff Hsieh, Paula L. Diaz-Sylvester and Laurent Brard

    Citation: BMC Cancer 2017 17:49

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  14. Content type: Research article

    Metabolic toxicities of mTOR inhibitors (mTORi) are well characterized. The purpose of the study was to investigate the relationship between these metabolic toxicities and mTORi efficacy.

    Authors: M. Jebali, R. Elaidi, M. Brizard, J. Fouque, C. Takouchop, B. Sabatier, S. Oudard and J. Medioni

    Citation: BMC Cancer 2017 17:27

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  15. Content type: Research article

    In endemic area, nasopharyngeal carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and a...

    Authors: Mei-Chun Lin, Yong-Chong Lin, Syue-Ting Chen, Tai-Horng Young and Pei-Jen Lou

    Citation: BMC Cancer 2017 17:18

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  16. Content type: Research article

    Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. New anti-cancer agents are needed for treating late stage colorectal cancer as most of the deaths occur due to cancer metastasis. A recentl...

    Authors: Khayal Al-Khayal, Ahmed Alafeefy, Mansoor-Ali Vaali-Mohammed, Amer Mahmood, Ahmed Zubaidi, Omar Al-Obeed, Zahid Khan, Maha Abdulla and Rehan Ahmad

    Citation: BMC Cancer 2017 17:4

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  17. Content type: Research article

    Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cance...

    Authors: Jeffrey Wimsatt, Meghan Villers, Laurel Thomas, Stacey Kamarec, Caitlin Montgomery, Leo W. Y. Yeung, Yanqing Hu and Kim Innes

    Citation: BMC Cancer 2016 16:942

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  18. Content type: Research article

    The study was designed to develop a platform to verify whether the extract of herbs combined with chemotherapy drugs play a synergistic role in anti-tumor effects, and to provide experimental evidence and theo...

    Authors: Jun Xie, Jia-Hui Liu, Heng Liu, Xiao-Zhong Liao, Yuling Chen, Mei-Gui Lin, Yue-Yu Gu, Tao-Li Liu, Dong-Mei Wang, Hui Ge and Sui-Lin Mo

    Citation: BMC Cancer 2016 16:899

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  19. Content type: Research article

    The polyether antibiotic Salinomycin (Sal) is regarded as an inhibitor of cancer stem cells. Its effectiveness on human colorectal cancer (CRC) cells in vitro has been demonstrated before. The aim of this stud...

    Authors: Johannes Klose, Jana Eissele, Claudia Volz, Steffen Schmitt, Alina Ritter, Shen Ying, Thomas Schmidt, Ulrike Heger, Martin Schneider and Alexis Ulrich

    Citation: BMC Cancer 2016 16:896

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  20. Content type: Research article

    Neuroblastoma (NB) is a frequent pediatric tumor characterized by a poor prognosis where a majority of tumors progress despite intensive multimodality treatments. Autophagy, a self-degradative process in cells...

    Authors: Assila Belounis, Carine Nyalendo, Roxane Le Gall, Tina V. Imbriglio, Mohamed Mahma, Pierre Teira, Mona Beaunoyer, Sonia Cournoyer, Elie Haddad, Gilles Vassal and Hervé Sartelet

    Citation: BMC Cancer 2016 16:891

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  21. Content type: Research article

    Endostar is a new endogenous angiogenic inhibitor with implicated anti-tumor activity. This study was to investigate whether thoracic perfusion of Endostar could be used to control malignant pleural effusions ...

    Authors: Rong Biaoxue, Cai Xiguang, Liu Hua, Gao Wenlong and Yang Shuanying

    Citation: BMC Cancer 2016 16:888

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  22. Content type: Research article

    Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c.

    Authors: Don W. Coulter, Timothy R. McGuire, John G. Sharp, Erin M. McIntyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram S. Joshi, Xiaoyu Chen and Jonathan L. Vennerstrom

    Citation: BMC Cancer 2016 16:867

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  23. Content type: Research article

    Vorinostat, a histone deacetylase (HDAC) inhibitor, is a promising agent for cancer therapy. Combining vorinostat with cisplatin may relax the chromatin structure and facilitate the accessibility of cisplatin,...

    Authors: Chun-Hao Pan, Ying-Fang Chang, Ming-Shuo Lee, B-Chen Wen, Jen-Chung Ko, Sheng-Kai Liang and Mei-Chih Liang

    Citation: BMC Cancer 2016 16:857

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  24. Content type: Research article

    Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression of hairy and enhancer of split 1 (Hes-1) has not been investigated yet in resected specimens of CC. Notch signaling...

    Authors: Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose and Michiaki Unno

    Citation: BMC Cancer 2016 16:854

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  25. Content type: Research article

    Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing h...

    Authors: Hongxia Ye, Xiaojuan Liu, Jiangchuan Sun, Shenyin Zhu, Yi Zhu and Shufang Chang

    Citation: BMC Cancer 2016 16:831

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  26. Content type: Research article

    Endometrial cancer is the most common cancer of the female reproductive tract.

    Authors: Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski and Kamil Torres

    Citation: BMC Cancer 2016 16:822

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    The Erratum to this article has been published in BMC Cancer 2016 16:939

  27. Content type: Research article

    Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as eff...

    Authors: Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min and Hai-yan Hu

    Citation: BMC Cancer 2016 16:818

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  28. Content type: Research article

    Previous studies have reported that eEF-2 kinase is associated with tumour cell sensitivity to certain therapies. In the present study, we investigated the relationship between eEF-2 kinase and lapatinib, a du...

    Authors: Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin and PeiJian Peng

    Citation: BMC Cancer 2016 16:813

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  29. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide and is associated with substantial mortality. Because HCCs have strong resistance to conventional chemotherapeutic agents, n...

    Authors: Jae-Woo Jang, Yeonhwa Song, Kang Mo Kim, Jin-Sun Kim, Eun Kyung Choi, Joon Kim and Haengran Seo

    Citation: BMC Cancer 2016 16:810

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  30. Content type: Research article

    Cachexia is one of the most important causes of cancer-related death. Supplementation with branched-chain amino acids, particularly leucine, has been used to minimise loss of muscle tissue, although few studie...

    Authors: Laís Rosa Viana, Rafael Canevarolo, Anna Caroline Perina Luiz, Raquel Frias Soares, Camila Lubaczeuski, Ana Carolina de Mattos Zeri and Maria Cristina Cintra Gomes-Marcondes

    Citation: BMC Cancer 2016 16:764

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  31. Content type: Research article

    Curcuminoids of the spice turmeric and their enhanced derivatives have much potential as cancer treatments. They act on a wide variety of biological pathways, including those regulating cell division and circa...

    Authors: Ashapurna Sarma, Vishal P. Sharma, Arindam B. Sarkar, M. Chandra Sekar, Karunakar Samuel and Michael E. Geusz

    Citation: BMC Cancer 2016 16:759

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  32. Content type: Research article

    Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy, nephropathy, and vomiting are dose-limiting factors. Pr...

    Authors: Yoshihiro Seto, Fumiyasu Okazaki, Keiji Horikawa, Jing Zhang, Hitoshi Sasaki and Hideto To

    Citation: BMC Cancer 2016 16:756

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  33. Content type: Research article

    Mutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors can exhibit resistance t...

    Authors: Ruoxi Hong, Fei Ma, Weimin Zhang, Xiying Yu, Qing Li, Yang Luo, Changjun Zhu, Wei Jiang and Binghe Xu

    Citation: BMC Cancer 2016 16:725

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    The Erratum to this article has been published in BMC Cancer 2016 16:925

  34. Content type: Research article

    Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour ...

    Authors: Mary-Clare Cathcart, Zivile Useckaite, Clive Drakeford, Vikki Semik, Joanne Lysaght, Kathy Gately, Kenneth J. O’Byrne and Graham P. Pidgeon

    Citation: BMC Cancer 2016 16:707

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  35. Content type: Research article

    Iron is essential for cell replication, metabolism and growth. Because neoplastic cells have high iron requirements due to their rapid proliferation, iron depletion may be a novel therapeutic strategy for canc...

    Authors: Hirofumi Harima, Seiji Kaino, Taro Takami, Shuhei Shinoda, Toshihiko Matsumoto, Koichi Fujisawa, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida

    Citation: BMC Cancer 2016 16:702

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  36. Content type: Research article

    shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a hig...

    Authors: Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan and Christina M. Annunziata

    Citation: BMC Cancer 2016 16:678

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  37. Content type: Research article

    Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target fo...

    Authors: I. A. Netland, H. E. Førde, L. Sleire, L. Leiss, M. A. Rahman, B. S. Skeie, C. H. Gjerde, P. Ø. Enger and D. Goplen

    Citation: BMC Cancer 2016 16:657

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  38. Content type: Research article

    We report on the results of a phase II clinical trial of Panagen (tablet form of fragmented human DNA preparation) in breast cancer patients (placebo group n = 23, Panagen n = 57). Panagen was administered as an ...

    Authors: Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Potter, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva…

    Citation: BMC Cancer 2016 16:651

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  39. Content type: Research article

    High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the cell death pathway by interfering with caspase activation. SMAC-mimetics are smal...

    Authors: Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa and Alexander Pintzas

    Citation: BMC Cancer 2016 16:624

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  40. Content type: Research article

    Cyclophosphamide (CPA) can activate immunogenic tumor cell death, which induces immune-based tumor ablation and long-term anti-tumor immunity in a syngeneic C57BL/6 (B6) mouse GL261 glioma model when CPA is gi...

    Authors: Junjie Wu, Marie Jordan and David J. Waxman

    Citation: BMC Cancer 2016 16:623

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  41. Content type: Research article

    The radiopharmaceutical 131I-meta-iodobenzylguanidine (131I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from 131I-MIBG is likely to be obtained by its combination with ...

    Authors: Donna L. Nile, Colin Rae, Iain J. Hyndman, Mark N. Gaze and Robert J. Mairs

    Citation: BMC Cancer 2016 16:621

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  42. Content type: Research article

    Due to lack of a targeted therapy for the triple-negative breast cancer (TNBC) patients, it is important to explore this aggressive breast cancer type in more detail and to establish novel therapeutic approach...

    Authors: Michaela C. Huber, Rebecca Mall, Herbert Braselmann, Annette Feuchtinger, Sara Molatore, Katrin Lindner, Axel Walch, Eva Gross, Manfred Schmitt, Natalie Falkenberg and Michaela Aubele

    Citation: BMC Cancer 2016 16:615

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  43. Content type: Research article

    Chemoresistance is one of the most leading causes for tumor progression and recurrence of bladder cancer. Reactive oxygen species (ROS) plays a key role in the chemosensitivity of cancer cells. In the present ...

    Authors: Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu and Xiaowen Liang

    Citation: BMC Cancer 2016 16:578

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  44. Content type: Research article

    Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into diffe...

    Authors: Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie and Shuxin Huang

    Citation: BMC Cancer 2016 16:571

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  45. Content type: Research article

    Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. ...

    Authors: Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli and Elena S. Ratner

    Citation: BMC Cancer 2016 16:550

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  46. Content type: Research article

    The cancer stem cells (CSCs), a small subpopulation of cells in tumor are responsible for the tumor initiation, growth, recurrence and metastasis of cancer, as well as resistance of cancers to drugs or radioth...

    Authors: Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano and Yoshiya Ueyama

    Citation: BMC Cancer 2016 16:548

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  47. Content type: Research article

    Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. Treatment of a solid tumor by an effective vector for a suicide gene remains a challenge. Given the l...

    Authors: Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng and Fangzhou Song

    Citation: BMC Cancer 2016 16:545

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  48. Content type: Research article

    Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, nove...

    Authors: Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf and Abdelilah Aboussekhra

    Citation: BMC Cancer 2016 16:540

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  49. Content type: Research article

    The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to indu...

    Authors: Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes and Anne Hansen Ree

    Citation: BMC Cancer 2016 16:531

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