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BMC Cancer

Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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  1. Content type: Research article

    Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-d...

    Authors: Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova and Pablo Aviles

    Citation: BMC Cancer 2018 18:164

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  2. Content type: Research article

    Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends ...

    Authors: Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt and Todd M. Pitts

    Citation: BMC Cancer 2018 18:136

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  3. Content type: Research article

    Side-effects have been considered as the limitation of the chemotherapy agents’ administration and life quality in patients with ovarian cancers. In order to explore the influence of the chemotherapy agents co...

    Authors: Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang and Heng Cui

    Citation: BMC Cancer 2018 18:81

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  4. Content type: Study protocol

    Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation r...

    Authors: Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati and Vincent Fradet

    Citation: BMC Cancer 2018 18:64

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  5. Content type: Research article

    Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition.

    Authors: Chia-Hsin Chang, Wei-Ting Liu, Hui-Chi Hung, Chia-Yu Gean, Hong-Ming Tsai, Chun-Lin Su and Po-Wu Gean

    Citation: BMC Cancer 2017 17:905

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  6. Content type: Research article

    Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate e...

    Authors: Tayyaba Afsar, Suhail Razak, Muhammad Rashid khan and Ali Almajwal

    Citation: BMC Cancer 2017 17:883

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  7. Content type: Research article

    Well-known anti-malarial drug artemisinin exhibits potent anti-cancerous activities. In-vivo and in-vitro studies showed its anti-tumor and immunomodulatory properties signifying it as a potent drug candidate ...

    Authors: Kanchan Kumari, Sunita Keshari, Debomita Sengupta, Surendra C. Sabat and Sandip K. Mishra

    Citation: BMC Cancer 2017 17:858

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  8. Content type: Research article

    There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of chemotherapy for such patients remains unclear....

    Authors: Satoshi Ikeda, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Takashi Niwa, Akihiro Nishiyama, Toshihide Yokoyama, Akimasa Sekine, Takashi Ogura and Tadashi Ishida

    Citation: BMC Cancer 2017 17:797

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  9. Content type: Software

    Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity...

    Authors: Nicholas A. Clark, Marc Hafner, Michal Kouril, Elizabeth H. Williams, Jeremy L. Muhlich, Marcin Pilarczyk, Mario Niepel, Peter K. Sorger and Mario Medvedovic

    Citation: BMC Cancer 2017 17:698

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  10. Content type: Research article

    Neoplastic cells proliferate rapidly and obtain requisite building blocks by reprogramming metabolic pathways that favor growth. Previously, we observed that prostate cancer cells uptake and store lipids in th...

    Authors: Ranjana Mitra, Thuc T. Le, Priyatham Gorjala and Oscar B. Goodman Jr.

    Citation: BMC Cancer 2017 17:631

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  11. Content type: Research article

    Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; howev...

    Authors: Basile Tessier-Cloutier, Steve E. Kalloger, Mohammad Al-Kandari, Katy Milne, Dongxia Gao, Brad H. Nelson, Daniel J. Renouf, Brandon S. Sheffield and David F. Schaeffer

    Citation: BMC Cancer 2017 17:618

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  12. Content type: Study protocol

    Metastatic pancreatic cancer has a dismal prognosis, with a mean six-month progression-free survival of approximately 50% and a median survival of about 11 months. Despite intensive research, only slight impro...

    Authors: Jacek Hajda, Monika Lehmann, Ottheinz Krebs, Meinhard Kieser, Karsten Geletneky, Dirk Jäger, Michael Dahm, Bernard Huber, Tilman Schöning, Oliver Sedlaczek, Albrecht Stenzinger, Niels Halama, Volker Daniel, Barbara Leuchs, Assia Angelova, Jean Rommelaere…

    Citation: BMC Cancer 2017 17:576

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  13. Content type: Research article

    Mutations of the DNA repair proteins BRCA1/2 are synthetically lethal with the DNA repair enzyme poly(ADP-ribose) polymerase (PARP), which when inhibited, leads to cell death due to the absence of compensatory...

    Authors: Zhor Senhaji Mouhri, Elliot Goodfellow and Bertrand Jean-Claude

    Citation: BMC Cancer 2017 17:540

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  14. Content type: Research article

    177Lu-octreotate can be used to treat somatostatin receptor expressing neuroendocrine tumors. It is highly effective in animal models, but clinical studies have so far only demonstrate...

    Authors: Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z. Parris, Khalil Helou, Ola Nilsson and Eva Forssell-Aronsson

    Citation: BMC Cancer 2017 17:528

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  15. Content type: Study protocol

    Non-small cell lung cancer is the most common type of lung cancer. Surgery is proven to be the most effective treatment in early stages, despite its potential impact on quality of life. Pulmonary rehabilitatio...

    Authors: Stefania Fugazzaro, Stefania Costi, Carlotta Mainini, Besa Kopliku, Cristian Rapicetta, Roberto Piro, Roberta Bardelli, Patricia Filipa Sobral Rebelo, Carla Galeone, Giorgio Sgarbi, Filippo Lococo, Massimiliano Paci, Tommaso Ricchetti, Silvio Cavuto, Domenico Franco Merlo and Sara Tenconi

    Citation: BMC Cancer 2017 17:508

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  16. Content type: Study protocol

    Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of...

    Authors: Danielle Crawley, Ashish Chandra, Massimo Loda, Cheryl Gillett, Paul Cathcart, Ben Challacombe, Gary Cook, Declan Cahill, Aida Santa Olalla, Fidelma Cahill, Gincy George, Sarah Rudman and Mieke Van Hemelrijck

    Citation: BMC Cancer 2017 17:494

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  17. Content type: Research article

    Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from that of thr...

    Authors: Eva Lhuissier, Céline Bazille, Juliette Aury-Landas, Nicolas Girard, Julien Pontin, Martine Boittin, Karim Boumediene and Catherine Baugé

    Citation: BMC Cancer 2017 17:490

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  18. Content type: Research article

    As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Bo...

    Authors: Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi and Chia-Hwa Lee

    Citation: BMC Cancer 2017 17:440

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