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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

Page 1 of 11

  1. Content type: Research article

    Although the dual anti-HER2 therapy, namely, pertuzumab plus trastuzumab and docetaxel, has shown promising results in HER2+ breast cancer patients, whether the dose, efficacy and safety of this treatment diff...

    Authors: Shanshan Chen, Yu Liang, Zhangying Feng and Mingxia Wang

    Citation: BMC Cancer 2019 19:973

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  2. Content type: Research article

    Castrate Resistant Prostate Cancer (CRPC) is an advanced disease resistant to systemic traditional medical or surgical castration, and resistance is primarily attributed to reactivation of AR through multiple ...

    Authors: Louie Semaan, Navneet Mander, Michael L. Cher and Sreenivasa R. Chinni

    Citation: BMC Cancer 2019 19:972

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  3. Content type: Research article

    We previously reported the synergistic effect of S-1 and eribulin in preclinical models. In addition, our phase I study revealed the recommended dose for the phase II study of the combination therapy in advanc...

    Authors: Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike and Kazuhiko Nakagawa

    Citation: BMC Cancer 2019 19:962

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  4. Content type: Research article

    The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing a sequential HAIC-sora...

    Authors: Masaaki Kondo, Manabu Morimoto, Satoshi Kobayashi, Shinichi Ohkawa, Hisashi Hidaka, Takahide Nakazawa, Hiroshi Aikata, Takeshi Hatanaka, Daichi Takizawa, Kotaro Matsunaga, Chiaki Okuse, Michihiro Suzuki, Masataka Taguri, Takako Ishibashi, Kazushi Numata, Shin Maeda…

    Citation: BMC Cancer 2019 19:954

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  5. Content type: Research article

    In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Soph...

    Authors: Yuming Zou, Melika Sarem, Shengnan Xiang, Honggang Hu, Weidong Xu and V. Prasad Shastri

    Citation: BMC Cancer 2019 19:949

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  6. Content type: Research article

    Intra-arterial therapy with embolics is established for the treatment of malignancies of the liver. However, there are no studies comparing the different effects of various embolics used in clinical practice. ...

    Authors: Christian Ziemann, Jonas Roller, Markus M. Malter, Kira Keller, Otto Kollmar, Matthias Glanemann, Michael D. Menger and Jens Sperling

    Citation: BMC Cancer 2019 19:938

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  7. Content type: Research article

    Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetica...

    Authors: Meng Yuan, Chengcheng Liu, Jiao Li, Wenpeng Ma, Xiaozhuo Yu, Ping Zhang and Yanhong Ji

    Citation: BMC Cancer 2019 19:934

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  8. Content type: Research article

    Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer...

    Authors: Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott and Christine J. Hawkins

    Citation: BMC Cancer 2019 19:924

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  9. Content type: Research article

    Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lenti...

    Authors: Jianhua Zhang, Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Shanshan Li, Bingjian Xue and Li Yan

    Citation: BMC Cancer 2019 19:921

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  10. Content type: Research article

    Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investiga...

    Authors: Eric C. Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N. Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier and Ramaprasad Srinivasan

    Citation: BMC Cancer 2019 19:917

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  11. Content type: Research article

    Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to...

    Authors: Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte and Annette Künkele

    Citation: BMC Cancer 2019 19:895

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  12. Content type: Research article

    Capacitive-resistive electric transfer (CRET) is a non-invasive therapeutic strategy that applies radiofrequency electric currents within the 400–600 kHz range to tissue repair and regeneration. Previous studi...

    Authors: María Luisa Hernández-Bule, Enrique Medel, Clara Colastra, Raquel Roldán and Alejandro Úbeda

    Citation: BMC Cancer 2019 19:889

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  13. Content type: Research article

    Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth fac...

    Authors: Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König and Marian Grade

    Citation: BMC Cancer 2019 19:880

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  14. Content type: Research article

    Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology...

    Authors: Reza Bayat Mokhtari, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Angelo Sparaneo, Lucia Anna Muscarella, Sheyun Zhao, Hai-Ling Cheng, Bikul Das and Herman Yeger

    Citation: BMC Cancer 2019 19:864

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  15. Content type: Research article

    The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM).

    Authors: Timothy R. McGuire, Don W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal S. Chhonker, Erin M. McIntyre, Gracey Alexander, John G. Sharp and Rongshi Li

    Citation: BMC Cancer 2019 19:837

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  16. Content type: Research article

    Treatment of acute myeloid leukemia (AML) in elderly patients remains a great challenge. In this prospective single arm study (ChiCTR-OPC-15006492), we evaluated the efficacy and safety of a novel consolidatio...

    Authors: Xiaoyang Li, Yuexin Dong, Ya Li, Ruibao Ren, Wen Wu, Hongming Zhu, Yunxiang Zhang, Jiong Hu and Junmin Li

    Citation: BMC Cancer 2019 19:819

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  17. Content type: Research article

    Adoptive transfer of immune cells such as T cells and natural killer (NK) cells has emerged as a targeted method of controlling the immune system against cancer. Despite their significant therapeutic potential...

    Authors: Jung-Won Choi, Eui Soo Lee, Se Young Kim, Su Il Park, Sena Oh, Jung Hwa Kang, Hyun Aae Ryu and Seahyoung Lee

    Citation: BMC Cancer 2019 19:817

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  18. Content type: Research article

    To describe the patterns of second-line treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel treatment in a Spanish population, to identify the factors associated ...

    Authors: Javier Puente, Aranzazu González-del-Alba, Núria Sala-Gonzalez, María José Méndez-Vidal, Alvaro Pinto, Ángel Rodríguez, José Miguel Cuevas Sanz, Jacobo Rodrigo Muñoz del Toro, Eduardo Useros Rodríguez, Ángela García García-Porrero and Sergio Vázquez

    Citation: BMC Cancer 2019 19:766

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  19. Content type: Research article

    MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs wer...

    Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao and Yaacov Ben-David

    Citation: BMC Cancer 2019 19:764

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  20. Content type: Research article

    Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy,...

    Authors: Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin and Jen-Tsung Yang

    Citation: BMC Cancer 2019 19:756

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  21. Content type: Research article

    Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear. Here, we investigated the relat...

    Authors: Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Dae-Hee Lee and Sang Cheul Oh

    Citation: BMC Cancer 2019 19:739

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  22. Content type: Research article

    Soft tissue sarcoma (STS) comprises a family of rare, heterogeneous tumors of mesenchymal origin. Single-agent doxorubicin remains the first-line standard-of-care treatment for advanced and inoperable STS, but...

    Authors: Jasmien Cornillie, Agnieszka Wozniak, Britt Van Renterghem, Nathalie Van Winkel, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes and Patrick Schöffski

    Citation: BMC Cancer 2019 19:724

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  23. Content type: Research article

    Multiple myeloma (MM), characterized by cancerous proliferation of plasmablasts (PB) and plasma cells (PC), remains incurable in many patients. Differentially expressed molecules between MM PCs and healthy PCs...

    Authors: Ying Fang, Ruonan Xu, Bing Zhai, Chunmei Hou, Ning Ma, Liang Wang, Gencheng Han, Zhenyu Jiang and Renxi Wang

    Citation: BMC Cancer 2019 19:700

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  24. Content type: Research article

    While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle p...

    Authors: Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi and Hiroyuki Tsuchiya

    Citation: BMC Cancer 2019 19:689

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  25. Content type: Research article

    Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and t...

    Authors: Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao and Tse-Hung Huang

    Citation: BMC Cancer 2019 19:634

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  26. Content type: Research article

    Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. ...

    Authors: Tim N. Beck, Alexander Y. Deneka, Louis Chai, Colin Kanach, Priya Johal, Nicolas J. Alvarez, Yanis Boumber, Erica A. Golemis and Glenn W. Laub

    Citation: BMC Cancer 2019 19:614

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  27. Content type: Research article

    Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and is involved in tumor metastasis and malignant progression. In previous studies, we generated a functional blocking monoclonal ...

    Authors: Mengqiao Xu, Xia Wang, Yanfang Pan, Xingpeng Zhao, Bin Yan, Changgeng Ruan, Lijun Xia and Yiming Zhao

    Citation: BMC Cancer 2019 19:599

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  28. Content type: Study protocol

    Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall surv...

    Authors: Sarah R. Brown, Andrew Hall, Hannah L. Buckley, Louise Flanagan, David Gonzalez de Castro, Kate Farnell, Laura Moss, Rebecca Gregory, Kate Newbold, Yong Du, Glenn Flux and Jonathan Wadsley

    Citation: BMC Cancer 2019 19:582

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  29. Content type: Research article

    Molecular markers predicting survival in esophageal adenocarcinoma (EAC) are rare. Specifically, in favorable oncologic situations, e.g. nodal negativity or major neoadjuvant therapy response, there is a lack ...

    Authors: Lars M. Schiffmann, Heike Göbel, Heike Löser, Fabian Schorn, Jan Paul Werthenbach, Hans F. Fuchs, Patrick S. Plum, Marc Bludau, Thomas Zander, Wolfgang Schröder, Christiane J. Bruns, Hamid Kashkar, Alexander Quaas and Florian Gebauer

    Citation: BMC Cancer 2019 19:531

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  30. Content type: Research article

    The phase III EMILIA and TH3RESA trials demonstrated clinical benefits of trastuzumab emtansine (T-DM1) therapy in patients with previously treated HER2-positive metastatic breast cancer (MBC). Data from these...

    Authors: Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre and Paul Anthony Ellis

    Citation: BMC Cancer 2019 19:517

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    The Correction to this article has been published in BMC Cancer 2019 19:620

  31. Content type: Research article

    Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Survivin-responsive, conditionally replicating adenoviruses reg...

    Authors: Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi, Makoto Yoshimitsu, Naomichi Arima, Kenji Ishitsuka, Shin-ichi Ueno and Ken-ichiro Kosai

    Citation: BMC Cancer 2019 19:516

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  32. Content type: Research article

    Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis. Recurrence and...

    Authors: Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong and Sung Joo Kim

    Citation: BMC Cancer 2019 19:496

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  33. Content type: Study protocol

    Testosterone suppression is the standard treatment for advanced prostate cancer, and it is associated with side-effects that impair patients’ quality of life, like sexual dysfunction, osteoporosis, weight gain...

    Authors: Gustavo Werutsky, Fernando Cotait Maluf, Eduardo Henrique Cronemberger, Vinicius Carrera Souza, Suelen Patricia dos Santos Martins, Fábio Peixoto, Oren Smaletz, Fábio Schutz, Daniel Herchenhorn, Telma Santos, Flavio Mavignier Carcano, David Queiroz Muniz, Paulo R. S. Nunes Filho, Facundo Zaffaroni, Carlos Barrios and André Fay

    Citation: BMC Cancer 2019 19:487

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  34. Content type: Study protocol

    While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic ...

    Authors: Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M. Nilsson, Jonas A. Nilsson and Lars Ny

    Citation: BMC Cancer 2019 19:415

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  35. Content type: Technical advance

    Previous work in our laboratory demonstrated that antiprogestin mifepristone impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in their cellular morphology. In this study, w...

    Authors: Sabrina J. Ritch, BreeAnn N. Brandhagen, Alicia A. Goyeneche and Carlos M. Telleria

    Citation: BMC Cancer 2019 19:376

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  36. Content type: Research article

    Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metast...

    Authors: Subhayan Sur, Hiroshi Nakanishi, Robert Steele and Ratna B. Ray

    Citation: BMC Cancer 2019 19:354

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  37. Content type: Research article

    Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more ag...

    Authors: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke and Tracy Robson

    Citation: BMC Cancer 2019 19:351

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  38. Content type: Research article

    The exact signalling mechanism of the mTOR complex remains a subject of constant debate, even with some evidence that amino acids participate in the same pathway as used for insulin signalling during protein s...

    Authors: Bread Cruz, André Oliveira, Gislaine Ventrucci and Maria Cristina Cintra Gomes-Marcondes

    Citation: BMC Cancer 2019 19:349

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  39. Content type: Research article

    Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, w...

    Authors: Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje and Vladimir L. Sukhorukov

    Citation: BMC Cancer 2019 19:299

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  40. Content type: Research article

    With poor prognosis and limited treatment options for advanced hepatocellular carcinoma (HCC), development of novel therapeutic agents is urgently needed. This single-arm phase I study sought to assess the saf...

    Authors: Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng and Binghe Xu

    Citation: BMC Cancer 2019 19:279

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  41. Content type: Research article

    Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed ...

    Authors: Melanie F. Pradier, Bernhard Reis, Lori Jukofsky, Francesca Milletti, Toshihiko Ohtomo, Fernando Perez-Cruz and Oscar Puig

    Citation: BMC Cancer 2019 19:278

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  42. Content type: Research article

    Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease. However, an un-met clinical need remains in B-Raf inhibitor resist...

    Authors: Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux and George S. Baillie

    Citation: BMC Cancer 2019 19:266

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  43. Content type: Research article

    Epithelial-mesenchymal transition (EMT) may be one of the reasons for the failure in some clinical trials regarding histone deacetylase inhibitors (HDACIs)-treated solid tumors. We investigated the effects of ...

    Authors: Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He and Wei Jie

    Citation: BMC Cancer 2019 19:262

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  44. Content type: Research article

    Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed clo...

    Authors: Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter and Georgia Schäfer

    Citation: BMC Cancer 2019 19:248

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  45. Content type: Research article

    High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 ...

    Authors: Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte and Hagen S. Bachmann

    Citation: BMC Cancer 2019 19:243

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  46. Content type: Case report

    Patients with relapsed/refractory acute myeloid leukemia after hematopoietic stem cell transplantation (HSCT) have a poor prognosis, with a 2-year survival rate of 14%. The optimal treatment for these patients...

    Authors: Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang and Guoqing Wei

    Citation: BMC Cancer 2019 19:242

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    The Correction to this article has been published in BMC Cancer 2019 19:486