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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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  1. Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion ...

    Authors: Neal Shah, Zhongwei Liu, Rachel M. Tallman, Afroz Mohammad, Samuel A. Sprowls, Pushkar A. Saralkar, Schuyler D. Vickers, Mark V. Pinti, Weimin Gao and Paul R. Lockman

    Citation: BMC Cancer 2020 20:292

    Content type: Research article

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  2. While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients’ quality of life...

    Authors: Kazumi Sano, Kazuhiko Nakadate and Kazuhiko Hanada

    Citation: BMC Cancer 2020 20:279

    Content type: Research article

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  4. Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MA...

    Authors: Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser and Steven R. Whittaker

    Citation: BMC Cancer 2020 20:269

    Content type: Research article

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  5. Clinical outcomes of patients with osteosarcoma remain unsatisfactory, with little improvement in a 5-year overall survival over the past three decades. There is a substantial need for further research and dev...

    Authors: Nut Koonrungsesomboon, Nuttapong Ngamphaiboon, Natavudh Townamchai, Pimpisa Teeyakasem, Chaiyut Charoentum, Pimlak Charoenkwan, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Touch Ativitavas, Parunya Chaiyawat, Jeerawan Klangjorhor, Suradej Hongeng and Dumnoensun Pruksakorn

    Citation: BMC Cancer 2020 20:268

    Content type: Study protocol

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  6. Immune checkpoint inhibitors (ICI) are an integral part of bladder cancer therapy, however, the relevance of ICI treatment for mixed and pure squamous cell carcinoma of the bladder remains poorly studied. Ther...

    Authors: Ronja Morsch, Michael Rose, Angela Maurer, Maria Angela Cassataro, Till Braunschweig, Ruth Knüchel, Thomas-Alexander Vögeli, Thorsten Ecke, Markus Eckstein, Veronika Weyerer, Irene Esposito, Maximilian Ackermann, Günter Niegisch and Nadine T. Gaisa

    Citation: BMC Cancer 2020 20:230

    Content type: Research article

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  7. Simeoni and colleagues introduced a compartmental model for tumor growth that has proved quite successful in modeling experimental therapeutic regimens in oncology. The model is based on a system of ordinary d...

    Authors: James A. Koziol, Theresa J. Falls and Jan E. Schnitzer

    Citation: BMC Cancer 2020 20:226

    Content type: Technical advance

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  8. Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be target...

    Authors: Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss and Catrin Roolf

    Citation: BMC Cancer 2020 20:184

    Content type: Research article

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  9. Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available...

    Authors: Evelina Miele, Luana Abballe, Gian Paolo Spinelli, Zein Mersini Besharat, Giuseppina Catanzaro, Martina Chiacchiarini, Alessandra Vacca, Agnese Po, Carlo Capalbo and Elisabetta Ferretti

    Citation: BMC Cancer 2020 20:129

    Content type: Research article

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  10. Currently, complete surgical resection represents the only potentially curative treatment option for Biliary Tract Cancer (BTC) including Gallbladder Cancer (GBC). Even after curative resection, 5-year OS is o...

    Authors: Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, Tobias Keck, Alfred Königsrainer, Sven A. Lang, Claudia Pauligk, Pompiliu Piso, Arndt Vogel and Salah-Eddin Al-Batran

    Citation: BMC Cancer 2020 20:122

    Content type: Study protocol

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  12. The SWI/SNF complex is an important chromatin remodeler, commonly dysregulated in cancer, with an estimated mutation frequency of 20%. ARID1A is the most frequently mutated subunit gene. Almost nothing is know...

    Authors: Simon Schallenberg, Julian Bork, Ahlem Essakly, Hakan Alakus, Reinhard Buettner, Axel M. Hillmer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Heike Loeser, Florian Gebauer and Alexander Quaas

    Citation: BMC Cancer 2020 20:12

    Content type: Research article

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  13. Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer ...

    Authors: Pradip Shahi Thakuri, Megha Gupta, Sunil Singh, Ramila Joshi, Eric Glasgow, Alexander Lekan, Seema Agarwal, Gary D. Luker and Hossein Tavana

    Citation: BMC Cancer 2020 20:4

    Content type: Research article

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  14. Bcl-2 family members play an important role in the development of malignant lymphoma and can induce drug resistance in anticancer treatment. The development of small molecules targeting Bcl-2 family proteins m...

    Authors: Yue-Li Sun, Wen-Qi Jiang, Qiu-Yun Luo, Da-Jun Yang, Yu-Chen Cai, Hui-Qiang Huang and Jian Sun

    Citation: BMC Cancer 2019 20:1

    Content type: Research article

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  15. Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MA...

    Authors: Sébastien Perreault, Valérie Larouche, Uri Tabori, Cynthia Hawkin, Sarah Lippé, Benjamin Ellezam, Jean-Claude Décarie, Yves Théoret, Marie-Élaine Métras, Serge Sultan, Édith Cantin, Marie-Ève Routhier, Maxime Caru, Geneviève Legault, Éric Bouffet, Lucie Lafay-Cousin…

    Citation: BMC Cancer 2019 19:1250

    Content type: Study protocol

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  16. Lung cancer (LC) is one of the leading causes of death worldwide, which highlights the urgent need for better therapies. Peroxisome proliferator-activated nuclear receptor alpha (PPARα), known as a key nuclear...

    Authors: Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen and Daowen Wang

    Citation: BMC Cancer 2019 19:1166

    Content type: Research article

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  18. The CAO/ARO/AIO-94 demonstrated that neoadjuvant chemoradiotherapy (CRT) could decrease the rate of local recurrence rather than distal metastases in advanced rectal cancer. Adjuvant chemotherapy (ACT) can eli...

    Authors: Qingguo Li, Dakui Luo, Ji Zhu, Lifeng Yang, Qi Liu, Yanlei Ma, Lei Liang, Sanjun Cai, Zhen Zhang and Xinxiang Li

    Citation: BMC Cancer 2019 19:1117

    Content type: Study protocol

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  19. Triple negative breast cancer (TNBC) represents 15–20% of breast cancers. Due to its heterogeneity and high rates of relapse, there is a need to optimize treatment efficacy. Platinum chemotherapy is still cont...

    Authors: Jessa Gilda P. Pandy, Joanmarie C. Balolong-Garcia, Mel Valerie B. Cruz-Ordinario and Frances Victoria F. Que

    Citation: BMC Cancer 2019 19:1065

    Content type: Research article

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  21. MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associate...

    Authors: Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi and Don W. Coulter

    Citation: BMC Cancer 2019 19:1056

    Content type: Research article

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  22. Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is ...

    Authors: Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal and Hervé Sartelet

    Citation: BMC Cancer 2019 19:1018

    Content type: Research article

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  23. Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemothera...

    Authors: Jung Min Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um and Chang Duck Kim

    Citation: BMC Cancer 2019 19:1016

    Content type: Research article

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  24. The high expression of BLM (Bloom syndrome) helicase in tumors involves its strong association with cell expansion. Bisbenzylisoquinoline alkaloids own an antitumor property and have developed as candidates fo...

    Authors: Wangming Zhang, Shuang Yang, Jinhe Liu, Linchun Bao, He Lu, Hong Li, Weidong Pan, Yanchao Jiao, Zhixu He and Jielin Liu

    Citation: BMC Cancer 2019 19:1009

    Content type: Research article

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  25. Although the dual anti-HER2 therapy, namely, pertuzumab plus trastuzumab and docetaxel, has shown promising results in HER2+ breast cancer patients, whether the dose, efficacy and safety of this treatment diff...

    Authors: Shanshan Chen, Yu Liang, Zhangying Feng and Mingxia Wang

    Citation: BMC Cancer 2019 19:973

    Content type: Research article

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  26. Castrate Resistant Prostate Cancer (CRPC) is an advanced disease resistant to systemic traditional medical or surgical castration, and resistance is primarily attributed to reactivation of AR through multiple ...

    Authors: Louie Semaan, Navneet Mander, Michael L. Cher and Sreenivasa R. Chinni

    Citation: BMC Cancer 2019 19:972

    Content type: Research article

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  27. We previously reported the synergistic effect of S-1 and eribulin in preclinical models. In addition, our phase I study revealed the recommended dose for the phase II study of the combination therapy in advanc...

    Authors: Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike and Kazuhiko Nakagawa

    Citation: BMC Cancer 2019 19:962

    Content type: Research article

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  28. The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing a sequential HAIC-sora...

    Authors: Masaaki Kondo, Manabu Morimoto, Satoshi Kobayashi, Shinichi Ohkawa, Hisashi Hidaka, Takahide Nakazawa, Hiroshi Aikata, Takeshi Hatanaka, Daichi Takizawa, Kotaro Matsunaga, Chiaki Okuse, Michihiro Suzuki, Masataka Taguri, Takako Ishibashi, Kazushi Numata, Shin Maeda…

    Citation: BMC Cancer 2019 19:954

    Content type: Research article

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  29. In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Soph...

    Authors: Yuming Zou, Melika Sarem, Shengnan Xiang, Honggang Hu, Weidong Xu and V. Prasad Shastri

    Citation: BMC Cancer 2019 19:949

    Content type: Research article

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  30. Intra-arterial therapy with embolics is established for the treatment of malignancies of the liver. However, there are no studies comparing the different effects of various embolics used in clinical practice. ...

    Authors: Christian Ziemann, Jonas Roller, Markus M. Malter, Kira Keller, Otto Kollmar, Matthias Glanemann, Michael D. Menger and Jens Sperling

    Citation: BMC Cancer 2019 19:938

    Content type: Research article

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  32. Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetica...

    Authors: Meng Yuan, Chengcheng Liu, Jiao Li, Wenpeng Ma, Xiaozhuo Yu, Ping Zhang and Yanhong Ji

    Citation: BMC Cancer 2019 19:934

    Content type: Research article

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  33. Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer...

    Authors: Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott and Christine J. Hawkins

    Citation: BMC Cancer 2019 19:924

    Content type: Research article

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  34. Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lenti...

    Authors: Jianhua Zhang, Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Shanshan Li, Bingjian Xue and Li Yan

    Citation: BMC Cancer 2019 19:921

    Content type: Research article

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  35. Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investiga...

    Authors: Eric C. Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N. Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier and Ramaprasad Srinivasan

    Citation: BMC Cancer 2019 19:917

    Content type: Research article

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  36. Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to...

    Authors: Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte and Annette Künkele

    Citation: BMC Cancer 2019 19:895

    Content type: Research article

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  37. Capacitive-resistive electric transfer (CRET) is a non-invasive therapeutic strategy that applies radiofrequency electric currents within the 400–600 kHz range to tissue repair and regeneration. Previous studi...

    Authors: María Luisa Hernández-Bule, Enrique Medel, Clara Colastra, Raquel Roldán and Alejandro Úbeda

    Citation: BMC Cancer 2019 19:889

    Content type: Research article

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  38. Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth fac...

    Authors: Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König and Marian Grade

    Citation: BMC Cancer 2019 19:880

    Content type: Research article

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  40. Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology...

    Authors: Reza Bayat Mokhtari, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Angelo Sparaneo, Lucia Anna Muscarella, Sheyun Zhao, Hai-Ling Cheng, Bikul Das and Herman Yeger

    Citation: BMC Cancer 2019 19:864

    Content type: Research article

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  41. The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM).

    Authors: Timothy R. McGuire, Don W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal S. Chhonker, Erin M. McIntyre, Gracey Alexander, John G. Sharp and Rongshi Li

    Citation: BMC Cancer 2019 19:837

    Content type: Research article

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  42. Treatment of acute myeloid leukemia (AML) in elderly patients remains a great challenge. In this prospective single arm study (ChiCTR-OPC-15006492), we evaluated the efficacy and safety of a novel consolidatio...

    Authors: Xiaoyang Li, Yuexin Dong, Ya Li, Ruibao Ren, Wen Wu, Hongming Zhu, Yunxiang Zhang, Jiong Hu and Junmin Li

    Citation: BMC Cancer 2019 19:819

    Content type: Research article

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  43. Adoptive transfer of immune cells such as T cells and natural killer (NK) cells has emerged as a targeted method of controlling the immune system against cancer. Despite their significant therapeutic potential...

    Authors: Jung-Won Choi, Eui Soo Lee, Se Young Kim, Su Il Park, Sena Oh, Jung Hwa Kang, Hyun Aae Ryu and Seahyoung Lee

    Citation: BMC Cancer 2019 19:817

    Content type: Research article

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  44. To describe the patterns of second-line treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel treatment in a Spanish population, to identify the factors associated ...

    Authors: Javier Puente, Aranzazu González-del-Alba, Núria Sala-Gonzalez, María José Méndez-Vidal, Alvaro Pinto, Ángel Rodríguez, José Miguel Cuevas Sanz, Jacobo Rodrigo Muñoz del Toro, Eduardo Useros Rodríguez, Ángela García García-Porrero and Sergio Vázquez

    Citation: BMC Cancer 2019 19:766

    Content type: Research article

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  45. MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs wer...

    Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao and Yaacov Ben-David

    Citation: BMC Cancer 2019 19:764

    Content type: Research article

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  46. Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy,...

    Authors: Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin and Jen-Tsung Yang

    Citation: BMC Cancer 2019 19:756

    Content type: Research article

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  47. Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear. Here, we investigated the relat...

    Authors: Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Dae-Hee Lee and Sang Cheul Oh

    Citation: BMC Cancer 2019 19:739

    Content type: Research article

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  48. Soft tissue sarcoma (STS) comprises a family of rare, heterogeneous tumors of mesenchymal origin. Single-agent doxorubicin remains the first-line standard-of-care treatment for advanced and inoperable STS, but...

    Authors: Jasmien Cornillie, Agnieszka Wozniak, Britt Van Renterghem, Nathalie Van Winkel, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes and Patrick Schöffski

    Citation: BMC Cancer 2019 19:724

    Content type: Research article

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  49. Multiple myeloma (MM), characterized by cancerous proliferation of plasmablasts (PB) and plasma cells (PC), remains incurable in many patients. Differentially expressed molecules between MM PCs and healthy PCs...

    Authors: Ying Fang, Ruonan Xu, Bing Zhai, Chunmei Hou, Ning Ma, Liang Wang, Gencheng Han, Zhenyu Jiang and Renxi Wang

    Citation: BMC Cancer 2019 19:700

    Content type: Research article

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  50. While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle p...

    Authors: Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi and Hiroyuki Tsuchiya

    Citation: BMC Cancer 2019 19:689

    Content type: Research article

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