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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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  1. Content type: Research article

    Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. ...

    Authors: Kate Butcher, Vinodh Kannappan, Rajagopal Sharada Kilari, Mark R. Morris, Christopher McConville, Angel L. Armesilla and Weiguang Wang

    Citation: BMC Cancer 2018 18:753

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  2. Content type: Research article

    Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, whi...

    Authors: Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan and Wee-Joo Chng

    Citation: BMC Cancer 2018 18:731

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  3. Content type: Research article

    High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggest...

    Authors: Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensberger, Richard Morgan, Daniel W. Lambert and Keith D. Hunter

    Citation: BMC Cancer 2018 18:723

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  4. Content type: Research article

    Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O

    Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung

    Citation: BMC Cancer 2018 18:714

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  5. Content type: Research article

    Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some b...

    Authors: Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang and Jeff Holst

    Citation: BMC Cancer 2018 18:689

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  6. Content type: Research article

    We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-...

    Authors: Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai…

    Citation: BMC Cancer 2018 18:680

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  7. Content type: Study protocol

    Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. T...

    Authors: A. J. M. van de Sande, M. M. Koeneman, C. G. Gerestein, A. J. Kruse, F. J. van Kemenade and H. J. van Beekhuizen

    Citation: BMC Cancer 2018 18:655

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  8. Content type: Research article

    Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human ...

    Authors: Asunción Martín-Ruiz, Laura Peña, Alfredo González-Gil, Lucía Teresa Díez-Córdova, Sara Cáceres and Juan Carlos Illera

    Citation: BMC Cancer 2018 18:626

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  9. Content type: Research article

    In patients with advanced hepatocellular carcinoma (HCC), evidence is unclear as to whether hepatic arterial infusion chemotherapy (HAIC) or sorafenib is superior. We performed a prospective, open-label, non-c...

    Authors: Masahiro Hatooka, Tomokazu Kawaoka, Hiroshi Aikata, Yuki Inagaki, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Kazuo Awai, Keiichi Masaki, Koji Waki, Hirotaka Kohno, Hiroshi Kohno…

    Citation: BMC Cancer 2018 18:633

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  10. Content type: Research article

    Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The disease recurrent rate is relatively high resulted in poor 5-year survival in advanced HCC. Cancer stem cells (...

    Authors: Wei-Chieh Huang, Shiao-Lin Tung, Yao-Li Chen, Po-Ming Chen and Pei-Yi Chu

    Citation: BMC Cancer 2018 18:609

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  11. Content type: Research article

    There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow micro...

    Authors: Eman Mosaad, Karen Chambers, Kathryn Futrega, Judith Clements and Michael Robert Doran

    Citation: BMC Cancer 2018 18:592

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  12. Content type: Research article

    Repurposing existing medications for antineoplastic purposes can provide a safe, cost-effective, and efficacious means to further augment available cancer care. Clinical and preclinical studies suggest a role ...

    Authors: Jennifer M. Knight, Stephanie A. Kerswill, Parameswaran Hari, Steve W. Cole, Brent R. Logan, Anita D’Souza, Nirav N. Shah, Mary M. Horowitz, Melinda R. Stolley, Erica K. Sloan, Karen E. Giles, Erin S. Costanzo, Mehdi Hamadani, Saurabh Chhabra, Binod Dhakal and J. Douglas Rizzo

    Citation: BMC Cancer 2018 18:593

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  13. Content type: Research article

    All known mechanisms of apoptosis induced by resveratrol act through cell cycle arrest and changes in mitochondrial membrane potential. It is currently unknown whether resveratrol-induced apoptosis is associat...

    Authors: Yingying Fan, Jen-Fu Chiu, Jing Liu, Yan Deng, Cheng Xu, Jun Zhang and Guanwu Li

    Citation: BMC Cancer 2018 18:581

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  14. Content type: Research article

    Patients with cancer develop endothelial dysfunction and subsequently display a higher risk of cardiovascular events. The aim of the present work was to examine changes in nitric oxide (NO)- and prostacyclin (PGI

    Authors: E. Buczek, A. Denslow, L. Mateuszuk, B. Proniewski, T. Wojcik, B. Sitek, A. Fedorowicz, A. Jasztal, E. Kus, A. Chmura- Skirlinska, R. Gurbiel, J. Wietrzyk and S. Chlopicki

    Citation: BMC Cancer 2018 18:582

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  15. Content type: Research article

    Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on C...

    Authors: Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao and Xuegang Sun

    Citation: BMC Cancer 2018 18:578

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  16. Content type: Research article

    Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal. We have rep...

    Authors: Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin and Muthusamy Kunnimalaiyaan

    Citation: BMC Cancer 2018 18:560

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  17. Content type: Research article

    Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration...

    Authors: Eszter Molnár, Dominika Rittler, Marcell Baranyi, Michael Grusch, Walter Berger, Balázs Döme, József Tóvári, Clemens Aigner, József Tímár, Tamás Garay and Balázs Hegedűs

    Citation: BMC Cancer 2018 18:542

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