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Epidemiology, prevention and public health

This section aims to consider publications which focus on all aspects of cancer epidemiology including risk factors for disease initiation and development, social determinants, environmental, behavioural, and occupational correlates, and the impact of health policies, practices and interventions on the community.

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  1. Content type: Research article

    Apolipoprotein E (ApoE) is a multifunctional protein playing both a key role in the metabolism of cholesterol and triglycerides, and in tissue repair and inflammation. The ApoE gene (19q13.2) has three major isof...

    Authors: Emma De Feo, Benedetto Simone, Roberto Persiani, Ferdinando Cananzi, Alberto Biondi, Dario Arzani, Rosarita Amore, Domenico D’Ugo, Gualtiero Ricciardi and Stefania Boccia

    Citation: BMC Cancer 2012 12:494

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  2. Content type: Research article

    Organised cervical screening, introduced in 1991, appears to have reduced rates of cervical cancer incidence and mortality in women in Australia. This study aimed to assess whether cervical cancer rates in mig...

    Authors: Nayyereh Aminisani, Bruce K Armstrong, Sam Egger and Karen Canfell

    Citation: BMC Cancer 2012 12:491

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  3. Content type: Research article

    The incidence of anal cancer, a Human Papillomavirus (HPV)-related neoplasia, has been increasing in recent decades, mainly in men who have sex with men (MSM). Cytological changes of the anal epithelium induce...

    Authors: Maria Gabriella Donà, Maria Benevolo, Amina Vocaturo, Guido Palamara, Alessandra Latini, Amalia Giglio, Domenico Moretto, Francesca Rollo, Giampaolo Impara, Fabrizio Ensoli, Fulvia Pimpinelli, Aldo Di Carlo and Massimo Giuliani

    Citation: BMC Cancer 2012 12:476

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  4. Content type: Research article

    Gastric cancer is the second most common cause of death from cancer in the world. Epidemiological findings on alcohol use in relation to gastric cancer remain controversial. The aim of this study was to examin...

    Authors: Ruta Everatt, Abdonas Tamosiunas, Irena Kuzmickiene, Dalia Virviciute, Ricardas Radisauskas, Regina Reklaitiene and Egle Milinaviciene

    Citation: BMC Cancer 2012 12:475

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  5. Content type: Research article

    Current studies on adherence to endocrine therapy in breast cancer patients suffer from methodological limitations due to a lack of well-validated methods for assessing adherence. There is no gold standard for...

    Authors: Anne S Oberguggenberger, Monika Sztankay, Beate Beer, Birthe Schubert, Verena Meraner, Herbert Oberacher, Georg Kemmler, Johannes Giesinger, Eva Gamper, Barbara Sperner-Unterweger, Christian Marth, Bernhard Holzner and Michael Hubalek

    Citation: BMC Cancer 2012 12:474

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  6. Content type: Research article

    A large proportion of women with breast cancer (BC) are elderly. However, there is a lack of information regarding BC prognostic factors and care in this population. The aims of this study were to assess the p...

    Authors: Pegdwende Olivia Dialla, Tienhan Sandrine Dabakuyo, Sophie Marilier, Julie Gentil, Patrick Roignot, Ariane Darut-Jouve, Marie-Laure Poillot, Valérie Quipourt and Patrick Arveux

    Citation: BMC Cancer 2012 12:472

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  7. Content type: Research article

    Adjuvant Online (AOL) is web-accessible risk-assessment model that predicts the mortality and the benefits of adjuvant therapy (http://​www.​newadjuvantonlin​e.​com

    Authors: Minkyu Jung, Geon Woo Kim, Inkyung Jung, Joong Bae Ahn, Jae Kyung Roh, Sun Young Rha, Hyun Cheol Chung, Nam Kyu Kim, Tae Il Kim and Sang Joon Shin

    Citation: BMC Cancer 2012 12:471

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  8. Content type: Research article

    There has been limited study on the effect of infection with different hepatitis C virus (HCV) genotypes on the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) endemic regions of Asia.

    Authors: Jin-Kyoung Oh, Hai-Rim Shin, Min Kyung Lim, Heeyoun Cho, Dong-Il Kim, Youngmee Jee, Haesun Yun and Keun-Young Yoo

    Citation: BMC Cancer 2012 12:452

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  9. Content type: Research article

    A 21-gene recurrence score (RS) assay may inform adjuvant systematic treatment decisions in women with early stage breast cancer. We sought to investigate the cost effectiveness of using the RS-assay versus cu...

    Authors: Malek B Hannouf, Bin Xie, Muriel Brackstone and Gregory S Zaric

    Citation: BMC Cancer 2012 12:447

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  10. Content type: Study protocol

    To reduce mortality, women with a family history of breast cancer often start mammography screening at a younger age than the general population. Breast density is high in over 50% of women younger than 50 yea...

    Authors: Sepideh Saadatmand, Emiel J T Rutgers, RobAEM Tollenaar, Hermien M Zonderland, MargreetGEM Ausems, KristienBMI Keymeulen, Margreet S Schlooz-Vries, Linetta B Koppert, Eveline A M Heijnsdijk, Caroline Seynaeve, Cees Verhoef, Jan C Oosterwijk, Inge-Marie Obdeijn, Harry J de Koning and Madeleine M A Tilanus-Linthorst

    Citation: BMC Cancer 2012 12:440

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  11. Content type: Study protocol

    There has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass an...

    Authors: Robert U Newton, Dennis R Taaffe, Nigel Spry, Prue Cormie, Suzanne K Chambers, Robert A Gardiner, David HK Shum, David Joseph and Daniel A Galvão

    Citation: BMC Cancer 2012 12:432

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  12. Content type: Research article

    Non-melanoma skin cancer (NMSC), comprised of basal (BCC) and squamous (SCC) cell carcinomas, is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental r...

    Authors: Michelle R Iannacone, Wei Wang, Heather G Stockwell, Kathleen O’Rourke, Anna R Giuliano, Vernon K Sondak, Jane L Messina, Richard G Roetzheim, Basil S Cherpelis, Neil A Fenske and Dana E Rollison

    Citation: BMC Cancer 2012 12:417

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  13. Content type: Research article

    Causes of the rapidly increasing incidence of breast cancer in Middle East and Asian countries are incompletely understood. We evaluated risk factors for postmenopausal breast cancer and estimated their attrib...

    Authors: Reza Ghiasvand, Shahram Bahmanyar, Kazem Zendehdel, Sedigheh Tahmasebi, Abdolrasoul Talei, Hans-Olov Adami and Sven Cnattingius

    Citation: BMC Cancer 2012 12:414

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  14. Content type: Study protocol

    After completion of curative breast cancer treatment, patients go through a transition from patient to survivor. During this re-entry phase, patients are faced with a broad range of re-entry topics, concerning...

    Authors: Sanne W van den Berg, Marieke F M Gielissen, Petronella B Ottevanger and Judith B Prins

    Citation: BMC Cancer 2012 12:394

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  15. Content type: Research article

    Lower concentrations of the insulin–like growth factor binding protein-1 (IGFBP-1) and elevated concentrations of insulin or C-peptide have been associated with an increase in colorectal cancer risk (CRC). How...

    Authors: Adriana C Vidal, Pauline Kay Lund, Cathrine Hoyo, Joseph Galanko, Lauren Burcal, Rachel Holston, Berri Massa, Oluwaseun Omofoye, Robert S Sandler and Temitope O Keku

    Citation: BMC Cancer 2012 12:389

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  16. Content type: Debate

    Peto's paradox stipulates that there is no association between body mass (a surrogate of number of cells and longevity) and cancer prevalence in wildlife species. Resolving this paradox is a very promising res...

    Authors: Benjamin Roche, Michael E Hochberg, Aleah F Caulin, Carlo C Maley, Robert A Gatenby, Dorothée Misse and Frédéric Thomas

    Citation: BMC Cancer 2012 12:387

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  17. Content type: Study protocol

    Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will...

    Authors: Rachel Dankner, Ran Balicer, Paolo Boffetta, Lital Keinan Boker, Sylvan Wallenstein, Laurence Freedman, Margalit Goldfracht, Jesse Roth, Ronald Tamler and Derek LeRoith

    Citation: BMC Cancer 2012 12:364

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  18. Content type: Study protocol

    Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect ...

    Authors: Annelies Overbeek, Marleen H van den Berg, Leontien CM Kremer, Marry M van den Heuvel-Eibrink, Wim JE Tissing, Jacqueline J Loonen, Birgitta Versluys, Dorine Bresters, Gertjan JL Kaspers, Cornelis B Lambalk, Flora E van Leeuwen and Eline van Dulmen-den Broeder

    Citation: BMC Cancer 2012 12:363

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  19. Content type: Research article

    Bladder cancer results from complex interactions between many genetic and environment factors. The polymorphism Ser326Cys in hOGG1 gene has been reported to be associated with bladder cancer in some studies, thou...

    Authors: Changwei Ji, Zhao Liu, Huimei Chen, Hongqian Guo and Changjian Liu

    Citation: BMC Cancer 2012 12:335

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  20. Content type: Study protocol

    Prostate cancer is the most commonly diagnosed non-melanoma cancer among men. Androgen deprivation therapy (ADT) has been the core therapy for men with advanced prostate cancer. It is only in recent years that...

    Authors: C Ellen Lee, Andrea Kilgour and YK James Lau

    Citation: BMC Cancer 2012 12:324

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  21. Content type: Study protocol

    Germline BRCA1 and BRCA2 mutation testing offered shortly after a breast cancer diagnosis to inform women’s treatment choices - treatment-focused genetic testing ‘TFGT’ - has entered clinical practice in speciali...

    Authors: Kaaren J Watts, Bettina Meiser, Gillian Mitchell, Judy Kirk, Christobel Saunders, Michelle Peate, Jessica Duffy, Patrick J Kelly, Margaret Gleeson, Kristine Barlow-Stewart, Belinda Rahman, Michael Friedlander and Kathy Tucker

    Citation: BMC Cancer 2012 12:320

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  22. Content type: Research article

    Studies have revealed both higher cancer survival in the US than in Germany and substantial improvement of cancer survival in the past in these countries. This population-based study aims at comparing most rec...

    Authors: Bernd Holleczek and Hermann Brenner

    Citation: BMC Cancer 2012 12:317

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  23. Content type: Research article

    Evaluating the cost-effectiveness of breast cancer screening requires estimates of the absolute risk of breast cancer, which is modified by various risk factors. Breast cancer incidence, and thus mortality, is...

    Authors: Sharareh Taghipour, Dragan Banjevic, Joanne Fernandes, Anthony B Miller, Neil Montgomery, Andrew K S Jardine and Bart J Harvey

    Citation: BMC Cancer 2012 12:299

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  24. Content type: Study protocol

    Postcancer fatigue is a frequently occurring, severe, and invalidating problem, impairing quality of life. Although it is possible to effectively treat postcancer fatigue with cognitive behaviour therapy, the ...

    Authors: Hetty Prinsen, Gijs Bleijenberg, Machiel J Zwarts, Maria T E Hopman, Arend Heerschap and Hanneke W M van Laarhoven

    Citation: BMC Cancer 2012 12:256

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  25. Content type: Study protocol

    Pap screening, an effective method for cervical cancer prevention, is now supported by molecular human papillomavirus (HPV) testing. Recently commercialised preventive vaccines also provide new tools for the p...

    Authors: Giovanna Orlando, Elisabetta Tanzi, Liliane Chatenoud, Maria Gramegna and Giuliano Rizzardini

    Citation: BMC Cancer 2012 12:204

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  26. Content type: Research article

    This study systematically reviewed the evidence on the influence of stigma and nihilism on lung cancer patterns of care; patients’ psychosocial and quality of life (QOL) outcomes; and how this may link to publ...

    Authors: Suzanne K Chambers, Jeffrey Dunn, Stefano Occhipinti, Suzanne Hughes, Peter Baade, Sue Sinclair, Joanne Aitken, Pip Youl and Dianne L O’Connell

    Citation: BMC Cancer 2012 12:184

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  27. Content type: Study protocol

    Psychological distress is common in cancer survivors. Although there is some evidence on effectiveness of psychosocial care in distressed cancer patients, referral rate is low. Lack of adequate screening instr...

    Authors: Anne-Marie H Krebber, C René Leemans, Remco de Bree, Annemieke van Straten, Filip Smit, Egbert F Smit, Annemarie Becker, Guus M Eeckhout, Aartjan TF Beekman, Pim Cuijpers and Irma M Verdonck-de Leeuw

    Citation: BMC Cancer 2012 12:173

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  28. Content type: Study protocol

    In the US, Hispanic women have a higher incidence of, and mortality from, cervical cancer than non-Hispanic white women. The reason for this disparity may be attributable to both low rates of screening and poo...

    Authors: Catherine Duggan, Gloria Coronado, Javiera Martinez, Theresa L Byrd, Elizabeth Carosso, Cathy Lopez, Maria Benavides and Beti Thompson

    Citation: BMC Cancer 2012 12:170

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  29. Content type: Research article

    The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing ...

    Authors: Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei and Guojun Li

    Citation: BMC Cancer 2012 12:159

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  30. Content type: Research article

    To determine the impact of preexisting ischemic heart disease (IHD) and stroke on overall survival in prostate cancer patients.

    Authors: Christina G Jespersen, Mette Nørgaard, Truls E Bjerklund Johansen, Mette Søgaard and Michael Borre

    Citation: BMC Cancer 2011 11:519

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  31. Content type: Research article

    In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in wom...

    Authors: Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su and Chih-Ching Yeh

    Citation: BMC Cancer 2011 11:495

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  32. Content type: Research article

    Concomitant chemo-radiotherapy (CCRT) has become an indispensable organ, but not always function preserving treatment modality for advanced head and neck cancer. To prevent/limit the functional side effects of...

    Authors: Valesca P Retèl, Lisette van der Molen, Frans JM Hilgers, Coen RN Rasch, Annemiek AAMHJ L'Ortye, Lotte MG Steuten and Wim H van Harten

    Citation: BMC Cancer 2011 11:475

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  33. Content type: Research article

    Human papillomaviruses (HPV) are causally associated with ano-genital and a subset of head and neck cancers. Rising incidence of HPV+ anal cancers and head and neck cancers have now been demonstrated in the de...

    Authors: Robin Crawford, Anne-Laure Grignon, Sarah Kitson, David M Winder, Siolian LR Ball, Katie Vaughan, Margaret A Stanley, Jane C Sterling and Peter KC Goon

    Citation: BMC Cancer 2011 11:473

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  34. Content type: Research article

    Overall, Indigenous Australians with cancer are diagnosed with more advanced disease, receive less cancer treatment and have poorer cancer survival than non-Indigenous Australians. The prognosis for Indigenous...

    Authors: Suzanne P Moore, Adèle C Green, Gail Garvey, Michael D Coory and Patricia C Valery

    Citation: BMC Cancer 2011 11:460

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  35. Content type: Research article

    Cigarette smoking is an established risk factor of lung cancer development while the current epidemiological evidence is suggestive of an increased lung cancer risk associated with alcohol consumption. Dietary...

    Authors: Chikako Kiyohara, Takahiko Horiuchi, Koichi Takayama and Yoichi Nakanishi

    Citation: BMC Cancer 2011 11:459

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  36. Content type: Research article

    Magnolol, a plant lignan isolated from the bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on chemically-induced skin cancer development. The objectives of this investi...

    Authors: Chandeshwari Chilampalli, Ruth Guillermo, Xiaoying Zhang, Radhey S Kaushik, Alan Young, David Zeman, Michael B Hildreth, Hesham Fahmy and Chandradhar Dwivedi

    Citation: BMC Cancer 2011 11:456

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  37. Content type: Research article

    It is well established that drinking alcohol raises the risk of liver cancer (hepatocellular carcinoma). However, it has not been sufficiently established as to whether or not drinking cessation subsequently r...

    Authors: Gawain A Heckley, Johan Jarl, Benedict O Asamoah and Ulf G-Gerdtham

    Citation: BMC Cancer 2011 11:446

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  38. Content type: Research article

    The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of bre...

    Authors: Elrasheid AH Kheirelseid, Jennifer ME Boggs, Catherine Curran, Ronan W Glynn, Cara Dooley, Karl J Sweeney and Michael J Kerin

    Citation: BMC Cancer 2011 11:383

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  39. Content type: Research article

    The National Comprehensive Cancer Network clinical practice guidelines in oncology-gastric cancer guidelines have been widely used to provide appropriate recommendations for the treatment of patients with gast...

    Authors: Xiaolong Zhang, Nanjing Li, Wen Wei, Wenxiu Yao, Ke Xie, Jiankun Hu, Lida Shen, Weizheng Ji, You Lu, Feng Wen, Yu Jiang, Feng Xu, Hong Feng, Feng Bi and Qiu Li

    Citation: BMC Cancer 2011 11:369

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  40. Content type: Research article

    This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure ...

    Authors: Emily Power, Alice Simon, Dorota Juszczyk, Sara Hiom and Jane Wardle

    Citation: BMC Cancer 2011 11:366

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  41. Content type: Research article

    Oral cancer incidence is high on the Island of Puerto Rico (PR), particularly among males. As part of a larger study conducted in PR, we evaluated smoking and drinking as risk factors for oral potentially mali...

    Authors: Lin Li, Walter J Psoter, Carmen J Buxó, Augusto Elias, Lumarie Cuadrado and Douglas E Morse

    Citation: BMC Cancer 2011 11:324

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  42. Content type: Research article

    Mammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequ...

    Authors: Spyros S Skandalis, Vassiliki T Labropoulou, Panagiota Ravazoula, Eleni Likaki-Karatza, Katalin Dobra, Haralabos P Kalofonos, Nikos K Karamanos and Achilleas D Theocharis

    Citation: BMC Cancer 2011 11:314

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