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Epidemiology, prevention and public health

This section aims to consider publications which focus on all aspects of cancer epidemiology including risk factors for disease initiation and development, social determinants, environmental, behavioural, and occupational correlates, and the impact of health policies, practices and interventions on the community.

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  1. The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, m...

    Authors: Seri Jeong, Seom Gim Kong, Da Jung Kim, Sangjin Lee and Ho Sup Lee

    Citation: BMC Cancer 2020 20:623

    Content type: Research article

    Published on:

  2. Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibilit...

    Authors: Lidia Delrieu, Amélie Anota, Olivier Trédan, Damien Freyssenet, Aurélia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Béatrice Fervers, Vincent Pialoux, David Pérol and Olivia Pérol

    Citation: BMC Cancer 2020 20:622

    Content type: Study protocol

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  3. Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the...

    Authors: Sivan Shamai, Zach Rozenbaum, Ofer Merimsky, Matthew Derakhshesh, Yonatan Moshkovits, Joshua Arnold, Yan Topilsky, Yaron Arbel and Michal Laufer-Perl

    Citation: BMC Cancer 2020 20:609

    Content type: Research article

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  4. Since body mass index (BMI) is a convincing risk factor for breast cancer, it is speculated to be associated with lymph node metastasis. However, epidemiological studies are inconclusive. Therefore, this study...

    Authors: Junyi Wang, Yaning Cai, Fangfang Yu, Zhiguang Ping and Li Liu

    Citation: BMC Cancer 2020 20:601

    Content type: Research article

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  5. We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male p...

    Authors: Jin Bong Choi, Jun-Pyo Myong, Yunhee Lee, Inah Kim, Jung Ho Kim, Sung-Hoo Hong and U-Syn Ha

    Citation: BMC Cancer 2020 20:589

    Content type: Research article

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  6. In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more fre...

    Authors: David P. French, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Anthony Howell, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Lorna McWilliams, Katherine Payne…

    Citation: BMC Cancer 2020 20:570

    Content type: Study protocol

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  7. Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This stu...

    Authors: Friederike Ruddies, Muluken Gizaw, Brhanu Teka, Sarah Thies, Andreas Wienke, Andreas M. Kaufmann, Tamrat Abebe, Adamu Addissie and Eva Johanna Kantelhardt

    Citation: BMC Cancer 2020 20:563

    Content type: Research article

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  8. Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening...

    Authors: Michael Lake, Christine S. Shusted, Hee-Soon Juon, Russell K. McIntire, Charnita Zeigler-Johnson, Nathaniel R. Evans, Gregory C. Kane and Julie A. Barta

    Citation: BMC Cancer 2020 20:561

    Content type: Research article

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  9. The aim of this study was to establish a comprehensive nomogram for the cancer-specific survival (CSS) of patients with upper-tract urothelial carcinoma (UTUC) and compare it with the traditional American Join...

    Authors: Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya, Shengpeng Wang and Jun Lyu

    Citation: BMC Cancer 2020 20:534

    Content type: Research article

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  10. Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agre...

    Authors: Yichun Cheng, Liu Huang, Yunfeng Han, Chummun Vanisha, Shuwang Ge and Gang Xu

    Citation: BMC Cancer 2020 20:530

    Content type: Research article

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  11. Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed ...

    Authors: A. E. Howell, J. W. Robinson, R. E. Wootton, A. McAleenan, S. Tsavachidis, Q. T. Ostrom, M. Bondy, G. Armstrong, C. Relton, P. Haycock, R. M. Martin, J. Zheng and K. M. Kurian

    Citation: BMC Cancer 2020 20:508

    Content type: Research article

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  12. Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico...

    Authors: Francesca Sanges, Matteo Floris, Paolo Cossu-Rocca, Maria R. Muroni, Giovanna Pira, Silvana Anna Maria Urru, Renata Barrocu, Silvano Gallus, Cristina Bosetti, Maurizio D’Incalci, Alessandra Manca, Maria Gabriela Uras, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Dolores Palmas…

    Citation: BMC Cancer 2020 20:491

    Content type: Research article

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  13. The objective of this study was to develop a practical nomogram for predicting the cancer-specific survival (CSS) of patients with small-intestine adenocarcinoma.

    Authors: Na Wang, Jin Yang, Jun Lyu, Qingqing Liu, Hairong He, Jie Liu, Li Li, Xuequn Ren and Zhendong Li

    Citation: BMC Cancer 2020 20:505

    Content type: Research article

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  14. To investigate the performance of primary ultrasound (P-US) screening for breast cancer, and that of supplemental ultrasound (S-US) screening for breast cancer after negative mammography (MAM).

    Authors: Lei Yang, Shengfeng Wang, Liwen Zhang, Chao Sheng, Fengju Song, Ping Wang and Yubei Huang

    Citation: BMC Cancer 2020 20:499

    Content type: Research article

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  15. For epidemiological research, cancer registry datasets often need to be augmented with additional data. Data linkage is not feasible when there are no cases in common between data sets. We present a novel appr...

    Authors: Paul P. Fahey, Andrew Page, Glenn Stone and Thomas Astell-Burt

    Citation: BMC Cancer 2020 20:496

    Content type: Research article

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  16. Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study we...

    Authors: Yngvar Nilssen, Odd Terje Brustugun, Morten Tandberg Eriksen, Erik Skaaheim Haug, Bjørn Naume and Bjørn Møller

    Citation: BMC Cancer 2020 20:488

    Content type: Research article

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  17. Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey...

    Authors: Illya Martynov, Jessica Klima-Frysch and Joachim Schoenberger

    Citation: BMC Cancer 2020 20:486

    Content type: Research article

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  18. Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asian...

    Authors: Hind El yacoubi, Mohamed Lemine Sow, Fouad Kettani, Lamia Gamra, Amina Mestari, Lamia Jabri, Ibrahim Elghissassi and Hassan Errihani

    Citation: BMC Cancer 2020 20:479

    Content type: Research article

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  19. Oral cancer is a growing problem worldwide, with high incidence rates in South Asian countries. With increasing numbers of South Asian immigrants in developed countries, a possible rise in oral cancer cases is...

    Authors: Nidhi Saraswat, Rona Pillay, Bronwyn Everett and Ajesh George

    Citation: BMC Cancer 2020 20:477

    Content type: Research article

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  20. Advanced cancer stage at diagnosis may explain high cancer mortality among patients with a severe psychiatric illness (SPI). Studies to date investigating advanced stage cancer at diagnosis as a potential expl...

    Authors: Alyson L. Mahar, Paul Kurdyak, Timothy P. Hanna, Natalie G. Coburn and Patti A. Groome

    Citation: BMC Cancer 2020 20:476

    Content type: Research article

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  21. Self-sampling for HPV testing, as an alternative to the conventional speculum based sampling, is highly acceptable to women of screening ages. The aim of this study was to describe older women’s (60 to 75 year...

    Authors: Ruth S. Hermansson, Matts Olovsson, Catharina Gustavsson and Annika Kristina Lindström

    Citation: BMC Cancer 2020 20:473

    Content type: Research article

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  22. The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancer...

    Authors: Rong Cong, Fanfei Kong, Jian Ma, Qing Li, Qijun Wu and Xiaoxin Ma

    Citation: BMC Cancer 2020 20:464

    Content type: Research article

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  23. Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to eval...

    Authors: Jennifer Howlett, Eric Benzenine, Jonathan Cottenet, Pascal Foucher, Philippe Fagnoni and Catherine Quantin

    Citation: BMC Cancer 2020 20:461

    Content type: Research article

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  24. Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have ...

    Authors: Karolin Bucksch, Silke Zachariae, Stefan Aretz, Reinhard Büttner, Elke Holinski-Feder, Stefanie Holzapfel, Robert Hüneburg, Matthias Kloor, Magnus von Knebel Doeberitz, Monika Morak, Gabriela Möslein, Jacob Nattermann, Claudia Perne, Nils Rahner, Wolff Schmiegel, Karsten Schulmann…

    Citation: BMC Cancer 2020 20:460

    Content type: Research article

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  25. Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TAT...

    Authors: Guoming Hu, Shimin Wang, Kefang Zhong, Feng Xu, Liming Huang, Wei Chen and Pu Cheng

    Citation: BMC Cancer 2020 20:454

    Content type: Research article

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  26. UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to ide...

    Authors: Victoria G. Woof, Helen Ruane, David P. French, Fiona Ulph, Nadeem Qureshi, Nasaim Khan, D. Gareth Evans and Louise S. Donnelly

    Citation: BMC Cancer 2020 20:452

    Content type: Research article

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  27. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting cervical cancer and its precursors. This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role ...

    Authors: Jing Zhang, Deyu Zhang, Zhuo Yang, Xiaobin Wang and Danbo Wang

    Citation: BMC Cancer 2020 20:443

    Content type: Research article

    Published on:

  28. Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-spe...

    Authors: Xiao Wu, Wenfeng Yu, R. H. Petersen, Hongxu Sheng, Yiqing Wang, Wang Lv and Jian Hu

    Citation: BMC Cancer 2020 20:429

    Content type: Research article

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  29. Research and cancer care are closely intertwined; however, it is not clear whether physicians and nurses believe that clinical trials offer the best treatment for patients and, if so, whether this belief is ju...

    Authors: Zandra Engelbak Nielsen, Stefan Eriksson, Laurine Bente Schram Harsløf, Suzanne Petri, Gert Helgesson, Margrete Mangset and Tove E. Godskesen

    Citation: BMC Cancer 2020 20:401

    Content type: Research article

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  30. To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV as...

    Authors: Ditte Møller Ejegod, Camilla Lagheden, Ramya Bhatia, Helle Pedersen, Elia Alcañiz Boada, Karin Sundström, Javier Cortés, F. Xavier Bosch Josë, Kate Cuschieri, Joakim Dillner and Jesper Bonde

    Citation: BMC Cancer 2020 20:396

    Content type: Research article

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  31. The comprehensive geriatric assessment (CGA) is the gold standard in geriatric oncology to identify patients at high risk of adverse outcomes and optimize cancer and overall management. Many studies have demon...

    Authors: Sandrine Sourdet, Delphine Brechemier, Zara Steinmeyer, Stephane Gerard and Laurent Balardy

    Citation: BMC Cancer 2020 20:384

    Content type: Research article

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  32. The microbiome has been shown to affect the response to Immune Checkpoint Inhibitors (ICIs) in a small number of cancers and in preclinical models. Here, we sought to broadly survey cancers to identify those i...

    Authors: Daniel Spakowicz, Rebecca Hoyd, Mitchell Muniak, Marium Husain, James S. Bassett, Lei Wang, Gabriel Tinoco, Sandip H. Patel, Jarred Burkart, Abdul Miah, Mingjia Li, Andrew Johns, Madison Grogan, David P. Carbone, Claire F. Verschraegen, Kari L. Kendra…

    Citation: BMC Cancer 2020 20:383

    Content type: Research article

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  33. This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome of multiple tumor entities, the effect of the specific number of multidisciplinary tumor boards and potential d...

    Authors: Marius Freytag, Ulrich Herrlinger, Stefan Hauser, Franz G. Bauernfeind, Maria A. Gonzalez-Carmona, Jennifer Landsberg, Jens Buermann, Hartmut Vatter, Tobias Holderried, Thorsten Send, Martin Schumacher, Arne Koscielny, Georg Feldmann, Mario Heine, Dirk Skowasch, Niklas Schäfer…

    Citation: BMC Cancer 2020 20:355

    Content type: Research article

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  34. The relationships among PIK3CA mutations, medication use and tumor progression remains poorly understood. Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been...

    Authors: Anne Marie McCarthy, Nitya Pradeep Kumar, Wei He, Susan Regan, Michaela Welch, Beverly Moy, A. John Iafrate, Andrew T. Chan, Aditya Bardia and Katrina Armstrong

    Citation: BMC Cancer 2020 20:347

    Content type: Research article

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  35. Familial colorectal cancer type X (FCCTX) is a phenotypically defined subset of hereditary colorectal cancer with unknown and potentially heterogeneous genetic aetiology. FCCTX has been characterized as a colo...

    Authors: Christina Therkildsen, Maria Rasmussen, Lars Smith-Hansen, Thomas Kallemose, Lars Joachim Lindberg and Mef Nilbert

    Citation: BMC Cancer 2020 20:345

    Content type: Research article

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  36. To examine the tumor characteristics, treatments and survival outcomes of prostate cancer (PCa) patients with a prostate-specific antigen (PSA) level < 4 ng/ml.

    Authors: Zhibo Zheng, Zhien Zhou, Weigang Yan, Yi Zhou, Chuyan Chen, Hanzhong Li and Zhigang Ji

    Citation: BMC Cancer 2020 20:340

    Content type: Research article

    Published on:

  37. Concern for cardiovascular disease (particularly atrial fibrillation-AF) among women with breast cancer is becoming a major issue. We aimed at determining the incidence of cardiovascular disease events (AF, ar...

    Authors: Benoîte Mery, Antoine Fouilloux, Elise Rowinski, Judith Catella-Chatron, Jean-Baptiste Guichard, Antoine Da Costa, Fabien Tinquaut, N. Magné and Laurent Bertoletti

    Citation: BMC Cancer 2020 20:337

    Content type: Research article

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  38. Caregiving for childhood cancer survivors may be burdensome for caregivers and affect their physical health and health behaviors. However, studies examining health behaviors in caregivers of childhood cancer s...

    Authors: In Young Cho, Nack-Gyun Chung, Hee Jo Baek, Ji Won Lee, Ki Woong Sung, Dong Wook Shin, Jung Eun Yoo and Yun-Mi Song

    Citation: BMC Cancer 2020 20:296

    Content type: Research article

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  39. New Rural Cooperative Medical Scheme (NRCMS) was developed to improve the health security for rural residents. This study aimed to assess the trend of disparity between coastland and inland in medical expendit...

    Authors: Rong Fu, Zheng Lin, Fei He, Yixian Jiang, Zhenquan Zheng and Zhijian Hu

    Citation: BMC Cancer 2020 20:295

    Content type: Research article

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  40. Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in adults less than 50 years of age, is increasing. To confirm findings and identify contemporary trends worldwide, we conducted a sys...

    Authors: Khalid Saad El Din, Jonathan M. Loree, Eric C. Sayre, Sharlene Gill, Carl J. Brown, Hallie Dau and Mary A. De Vera

    Citation: BMC Cancer 2020 20:288

    Content type: Research article

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  41. The effects of dietary factors on prognosis of esophageal cancer remain unclear. This systematic review and meta-analysis aimed to assess the association between dietary intake and the risk of mortality among ...

    Authors: Li-Ping Sun, Lu-Bin Yan, Zhen-Zhen Liu, Wen-Jing Zhao, Cai-Xia Zhang, Yu-Min Chen, Xiang Qian Lao and Xudong Liu

    Citation: BMC Cancer 2020 20:287

    Content type: Research article

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  42. The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associ...

    Authors: Fränce Hardtstock, David Myers, Tracy Li, Diana Cizova, Ulf Maywald, Thomas Wilke and Frank Griesinger

    Citation: BMC Cancer 2020 20:260

    Content type: Research article

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  43. Colorectal cancer (CRC) cases are detected late in Malaysia similar to most Asian countries. The Be Cancer Alert Campaign (BCAC) was a culturally adapted mass media campaign designed to improve CRC awareness and ...

    Authors: Désirée Schliemann, Darishiani Paramasivam, Maznah Dahlui, Christopher R. Cardwell, Saunthari Somasundaram, Nor Saleha Binti Ibrahim Tamin, Conan Donnelly, Tin Tin Su and Michael Donnelly

    Citation: BMC Cancer 2020 20:252

    Content type: Research article

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  44. It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...

    Authors: Ruoxi Ding, Dawei Zhu, Ping He, Yong Ma, Zhishui Chen and Xuefeng Shi

    Citation: BMC Cancer 2020 20:250

    Content type: Research article

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  45. Increased knowledge of breast cancer risk factors has meant that we are currently exploring risk-based screening, i.e. determining screening strategies based on women’s varying levels of risk. This also enable...

    Authors: Linda Rainey, Daniëlle van der Waal, Anna Jervaeus, Louise S. Donnelly, D. Gareth Evans, Mattias Hammarström, Per Hall, Yvonne Wengström and Mireille J. M. Broeders

    Citation: BMC Cancer 2020 20:247

    Content type: Research article

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