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Epidemiology, prevention and public health

This section aims to consider publications which focus on all aspects of cancer epidemiology including risk factors for disease initiation and development, social determinants, environmental, behavioural, and occupational correlates, and the impact of health policies, practices and interventions on the community.

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  1. Content type: Research article

    Breast cancer incidence is increasing. The survival rate varies and is longer in high-income countries. In Brazil, lower-income populations rely on the Unified Public Health System (Sistema Único de Saude, SUS...

    Authors: Débora Balabram, Cassio M Turra and Helenice Gobbi

    Citation: BMC Cancer 2013 13:434

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  2. Content type: Study protocol

    Approximately 20–30% of patients with cancer experience a clinically relevant level of emotional distress in response to disease and treatment. This in itself is alarming but it is even more problematic becaus...

    Authors: Susanne Mattsson, Sven Alfonsson, Maria Carlsson, Peter Nygren, Erik Olsson and Birgitta Johansson

    Citation: BMC Cancer 2013 13:414

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  3. Content type: Research article

    Breast cancer is the leading malignant disease among western women with incidence increasing over time. High mammographic density is a well-established risk factor for breast cancer. We explored trends in mamm...

    Authors: Sophie Sell Hellmann, Elsebeth Lynge, Walter Schwartz, Ilse Vejborg and Sisse Helle Njor

    Citation: BMC Cancer 2013 13:409

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  4. Content type: Research article

    It is known that suboptimal adherence rates may affect endocrine treatments for breast cancer, but little information has been reported whether any efforts to improve treatment adherence have been successful. ...

    Authors: Volker Ziller, Ioannis Kyvernitakis, Dana Knöll, Astrid Storch, Olaf Hars and Peyman Hadji

    Citation: BMC Cancer 2013 13:407

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  5. Content type: Research article

    Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed t...

    Authors: Anne E Cust, Chris Goumas, Kylie Vuong, John R Davies, Jennifer H Barrett, Elizabeth A Holland, Helen Schmid, Chantelle Agha-Hamilton, Bruce K Armstrong, Richard F Kefford, Joanne F Aitken, Graham G Giles, D Timothy Bishop, Julia A Newton-Bishop, John L Hopper, Graham J Mann…

    Citation: BMC Cancer 2013 13:406

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  6. Content type: Study protocol

    Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be rel...

    Authors: Willemijn AM van Gemert, Jolein I Iestra, Albertine J Schuit, Anne M May, Tim Takken, Wouter B Veldhuis, Job van der Palen, Harriët Wittink, Petra HM Peeters and Evelyn M Monninkhof

    Citation: BMC Cancer 2013 13:395

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  7. Content type: Research article

    A lot of empirical studies have been conducted to evaluate the prevalence of depression and anxiety among Chinese adults with cancer. We aimed to conduct a meta-analysis in order to evaluate the prevalence and...

    Authors: Yi-Long Yang, Li Liu, Yang Wang, Hui Wu, Xiao-Shi Yang, Jia-Na Wang and Lie Wang

    Citation: BMC Cancer 2013 13:393

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  8. Content type: Research article

    Primary human papilloma virus (HPV) screening is more effective than cytology in reducing the risk of cervical cancer, but screening intervals should be extended in HPV-negative women. However, some Markov mod...

    Authors: Karl Ulrich Petry, Franziska Rinnau, Gerd Böhmer, Bettina Hollwitz, Alexander Luyten, Nina Buttmann, Martin Brünger and Thomas Iftner

    Citation: BMC Cancer 2013 13:379

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  9. Content type: Research article

    Few studies have investigated the impact of urinary incontinence (UI) on health-related quality of life (HRQOL) among cancer survivors. UI is prevalent in the general population and can be both an indicator of...

    Authors: Alexandra J White, Bryce B Reeve, Ronald C Chen, Angela M Stover and Debra E Irwin

    Citation: BMC Cancer 2013 13:377

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  10. Content type: Research article

    This paper presents the level of colorectal cancer awareness among multi-ethnic rural population in Malaysia.

    Authors: Tin Tin Su, Jun Yan Goh, Jackson Tan, Abdul Rahim Muhaimah, Yoganathan Pigeneswaren, Nasirin Sallamun Khairun, Abdul Wahab Normazidah, Devi Kunasekaran Tharisini and Hazreen Abd Majid

    Citation: BMC Cancer 2013 13:376

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  11. Content type: Research article

    New Zealand and Australia have the highest incidence and mortality rates from cutaneous melanoma in the world. The predominantly fair-skinned New Zealanders and Australians both enjoy sun, tanned skin and the ...

    Authors: Mary Jane Sneyd and Brian Cox

    Citation: BMC Cancer 2013 13:372

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  12. Content type: Research article

    We aimed to examine evidence for an infectious aetiology among teenagers and young adults (TYA) by analysing monthly seasonality of diagnosis and birth amongst 15–24 year olds diagnosed with cancer in England.

    Authors: Marlous van Laar, Sally E Kinsey, Susan V Picton and Richard G Feltbower

    Citation: BMC Cancer 2013 13:365

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  13. Content type: Research article

    Invasive cervical cancer is the second most common malignant tumor affecting Brazilian women. Knowledge on Human Papillomavirus (HPV) genotypes in invasive cervical cancer cases is crucial to guide the introdu...

    Authors: Cristina Mendes de Oliveira, José Humberto Tavares Guerreiro Fregnani, Jesus Paula Carvalho, Adhemar Longatto-Filho and José Eduardo Levi

    Citation: BMC Cancer 2013 13:357

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  14. Content type: Research article

    Venous thromboembolism (VTE) has been associated with a higher risk of developing malignancy and mortality, and patients with VTE may therefore benefit from increased surveillance. We aimed to construct a clin...

    Authors: Bruno L Ferreyro, Federico Angriman, Diego Giunta, María Lourdes Posadas-Martínez, Fernando Vazquez, Fernán Gonzalez Bernaldo De Quirós, Andre C K B Amaral and Damon C Scales

    Citation: BMC Cancer 2013 13:352

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  15. Content type: Research article

    Anemia refers to low hemoglobin (Hb) level and is a risk factor of cancer patient survival. The National Comprehensive Cancer Network recently suggested that post-diagnosis Hb change, regardless of baseline Hb...

    Authors: Shaogui Wan, Yinzhi Lai, Ronald E Myers, Bingshan Li, Juan P Palazzo, Ashlie L Burkart, Guokai Chen, Jinliang Xing and Hushan Yang

    Citation: BMC Cancer 2013 13:340

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  16. Content type: Research article

    Women with mutations in BRCA1 or BRCA2 are at high risk of developing breast cancer and, in British Columbia, Canada, are offered screening with both magnetic resonance imaging (MRI) and mammography to facilit...

    Authors: Reka Pataky, Linlea Armstrong, Stephen Chia, Andrew J Coldman, Charmaine Kim-Sing, Barbara McGillivray, Jenna Scott, Christine M Wilson and Stuart Peacock

    Citation: BMC Cancer 2013 13:339

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  17. Content type: Research article

    It is clear that genetic variations in the fat mass and obesity-associated (FTO) gene affect body mass index and the risk of obesity. Given the mounting evidence showing a positive association between obesity ...

    Authors: Yingsong Lin, Junko Ueda, Kiyoko Yagyu, Hiroshi Ishii, Makoto Ueno, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo and Shogo Kikuchi

    Citation: BMC Cancer 2013 13:337

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  18. Content type: Research article

    Considerable global variation in the incidence of lip, of oral cavity and of pharyngeal cancers exists. Whilst this reflects regional or population differences in risk, interpretation is uncertain due to heter...

    Authors: Anura Ariyawardana and Newell W Johnson

    Citation: BMC Cancer 2013 13:333

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  19. Content type: Research article

    Post-surgery therapies are given to early-stage breast cancer patients due to the possibility of residual micrometastasis, and optimized by clincopathological parameters such as tumor stage, and hormone recept...

    Authors: Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young

    Citation: BMC Cancer 2013 13:330

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  20. Content type: Research article

    Due to changes in cancer-related risk factors, improvements in diagnostic procedures and treatments, and the aging of the population, in most developed countries cancer accounts for an increasing proportion of...

    Authors: Silvia Francisci, Stefano Guzzinati, Maura Mezzetti, Emanuele Crocetti, Francesco Giusti, Guido Miccinesi, Eugenio Paci, Catia Angiolini and Anna Gigli

    Citation: BMC Cancer 2013 13:329

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  21. Content type: Research article

    Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic sus...

    Authors: Muhammad U Rashid, Noor Muhammad, Saima Faisal, Asim Amin and Ute Hamann

    Citation: BMC Cancer 2013 13:312

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  22. Content type: Research article

    Increasing evidence suggests that a history of diabetes mellitus (DM) may be associated with an increased risk of bladder cancer. We performed a systematic review with meta-analysis to explore this relationship.

    Authors: Zhaowei Zhu, Xianjin Wang, Zhoujun Shen, Yingli Lu, Shan Zhong and Chen Xu

    Citation: BMC Cancer 2013 13:310

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  23. Content type: Research article

    Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome ha...

    Authors: Jinlong Jian, Qing Yang, Yongzhao Shao, Deborah Axelrod, Julia Smith, Baljit Singh, Stephanie Krauter, Luis Chiriboga, Zhaoxu Yang, Jinqing Li and Xi Huang

    Citation: BMC Cancer 2013 13:307

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  24. Content type: Research article

    We usually report five-year survival from population-based cancer registries in Japan; however these survival estimates may be pessimistic for cancer survivors, because many patients with unfavourable prognosi...

    Authors: Yuri Ito, Tomio Nakayama, Isao Miyashiro, Akiko Ioka and Hideaki Tsukuma

    Citation: BMC Cancer 2013 13:304

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  25. Content type: Research article

    Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates were unknown. The relationshi...

    Authors: Hiu-Ying Lau, Chit-Ming Leung, Yap-Hang Chan, Anne Wing-Mui Lee, Dora Lai-Wan Kwong, Maria Li Lung and Tai-Hing Lam

    Citation: BMC Cancer 2013 13:298

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  26. Content type: Research article

    Cancer survivors are a heterogeneous group with complex health problems. Data concerning its total number and growing dynamics for Switzerland are scarce and outdated.

    Authors: Christian Herrmann, Thomas Cerny, Anita Savidan, Penelope Vounatsou, Isabelle Konzelmann, Christine Bouchardy, Harald Frick and Silvia Ess

    Citation: BMC Cancer 2013 13:287

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  27. Content type: Research article

    Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colo...

    Authors: Jonathan N Hofmann, Linda M Liao, Paul T Strickland, Xiao-Ou Shu, Gong Yang, Bu-Tian Ji, Hong-Lan Li, Nathaniel Rothman, Farin Kamangar, Yu-Tang Gao, Wei Zheng and Wong-Ho Chow

    Citation: BMC Cancer 2013 13:282

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  28. Content type: Research article

    Diffusely reflected light is influenced by cytologic and morphologic changes that take place during tissue transformation, such as, nuclear changes, extracellular matrix structure and composition as well as bl...

    Authors: Manju M Stephen, Jayaraj L Jayanthi, Nisha G Unni, Philip E Kolady, Valappil T Beena, Panniyammakal Jeemon and Narayanan Subhash

    Citation: BMC Cancer 2013 13:278

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  29. Content type: Study protocol

    Exercise seems to minimize prostate cancer specific mortality risk and treatment related side effects like fatigue and incontinence. However the influence of physical activity on the immunological level remain...

    Authors: Philipp Zimmer, Elke Jäger, Wilhelm Bloch, Eva Maria Zopf and Freerk T Baumann

    Citation: BMC Cancer 2013 13:272

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  30. Content type: Research article

    The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing bo...

    Authors: Janette Perz, Jane M Ussher and Emilee Gilbert

    Citation: BMC Cancer 2013 13:270

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  31. Content type: Research article

    Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi...

    Authors: Wahyu Wulaningsih, Karl Michaelsson, Hans Garmo, Niklas Hammar, Ingmar Jungner, Göran Walldius, Lars Holmberg and Mieke Van Hemelrijck

    Citation: BMC Cancer 2013 13:257

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  32. Content type: Research article

    Adjuvant chemotherapy (AC) improves survival among patients with operable breast cancer. However, the effect of delay in AC initiation on survival is unclear. We performed a systematic review and meta-analysis...

    Authors: Ke-Da Yu, Sheng Huang, Jia-Xin Zhang, Guang-Yu Liu and Zhi-Ming Shao

    Citation: BMC Cancer 2013 13:240

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  33. Content type: Research article

    The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in t...

    Authors: Pablo Conesa-Zamora, Javier Ruiz-Cosano, Daniel Torres-Moreno, Ignacio Español, María D Gutiérrez-Meca, Javier Trujillo-Santos, Elena Pérez-Ceballos, Rocío González-Conejero, Javier Corral, Vicente Vicente and Miguel Pérez-Guillermo

    Citation: BMC Cancer 2013 13:228

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  34. Content type: Research article

    Black women are more likely than white women to have an aggressive subtype of breast cancer that is associated with higher mortality and this may contribute to the observed black-white difference in mortality....

    Authors: Huiyan Ma, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Dennis M Deapen, Robert Spirtas, Ronald T Burkman, Brian L Strom, Jill A McDonald, Suzanne G Folger, Michael S Simon, Jane Sullivan-Halley, Michael F Press and Leslie Bernstein

    Citation: BMC Cancer 2013 13:225

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  35. Content type: Research article

    Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. The extent of venous thromboembolic co-morbid...

    Authors: Alexandra Connelly-Frost, Sumitra Shantakumar, Monica G Kobayashi, Haojie Li and Li Li

    Citation: BMC Cancer 2013 13:209

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  36. Content type: Research article

    In an ongoing study of racial/ethnic disparities in breast cancer stage atdiagnosis, we consented patients to allow us to review their mammogramimages, in order to examine the potential role of mammogram image...

    Authors: Garth H Rauscher, Emily F Conant, Jenna A Khan and Michael L Berbaum

    Citation: BMC Cancer 2013 13:208

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  37. Content type: Study protocol

    Up to 70% of cancer survivors report clinically significant levels of fear of cancer recurrence (FCR). Despite the known negative impact of FCR on psychological wellbeing and quality of life, little research h...

    Authors: Phyllis N Butow, Melanie L Bell, Allan B Smith, Joanna E Fardell, Belinda Thewes, Jane Turner, Jemma Gilchrist, Jane Beith, Afaf Girgis, Louise Sharpe, Sophy Shih and Cathrine Mihalopoulos

    Citation: BMC Cancer 2013 13:201

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  38. Content type: Study protocol

    Communication about prognosis and treatment choices is essential for informed decision making in advanced cancer. This article describes an investigation designed to facilitate communication and decision makin...

    Authors: Michael Hoerger, Ronald M Epstein, Paul C Winters, Kevin Fiscella, Paul R Duberstein, Robert Gramling, Phyllis N Butow, Supriya G Mohile, Paul R Kaesberg, Wan Tang, Sandy Plumb, Adam Walczak, Anthony L Back, Daniel Tancredi, Alison Venuti, Camille Cipri…

    Citation: BMC Cancer 2013 13:188

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  39. Content type: Research article

    Clinical interpretation of health related quality of life (HRQOL) scores is challenging. The purpose of this analysis was to interpret score changes and identify minimal clinically important differences (MCID)...

    Authors: Fanxing Hong, Jaclyn L F Bosco, Nigel Bush and Donna L Berry

    Citation: BMC Cancer 2013 13:165

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  40. Content type: Research article

    Besides conventional adjuvant therapies, many breast cancer survivors engage in various activities like exercise, diet and complementary and alternative medicine (CAM) in order to improve their prognosis. Litt...

    Authors: Arnoud J Templeton, Beat Thürlimann, Michael Baumann, Michael Mark, Sarah Stoll, Madeleine Schwizer, Daniel Dietrich and Thomas Ruhstaller

    Citation: BMC Cancer 2013 13:153

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  41. Content type: Study protocol

    Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA

    Authors: Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett and Elizabeth M Connolly

    Citation: BMC Cancer 2013 13:138

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  42. Content type: Research article

    The measurement properties of instruments used to assess functional capacity, physical activity and muscle strength in participants with non-small cell lung cancer (NSCLC) have not been systematically reviewed.

    Authors: Catherine L Granger, Christine F McDonald, Selina M Parry, Cristino C Oliveira and Linda Denehy

    Citation: BMC Cancer 2013 13:135

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  43. Content type: Research article

    A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (...

    Authors: Giovanna Mantegna, Marco Petrillo, Gilda Fuoco, Laura Venditti, Serena Terzano, Luigi Pedone Anchora, Giovanni Scambia and Gabriella Ferrandina

    Citation: BMC Cancer 2013 13:127

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  44. Content type: Research article

    Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study...

    Authors: Jorge Félix, Filipa Aragão, João M Almeida, Frederico JM Calado, Diana Ferreira, António BS Parreira, Ricardo Rodrigues and João FR Rijo

    Citation: BMC Cancer 2013 13:122

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