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Epidemiology, prevention and public health

This section aims to consider publications which focus on all aspects of cancer epidemiology including risk factors for disease initiation and development, social determinants, environmental, behavioural, and occupational correlates, and the impact of health policies, practices and interventions on the community.

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  1. Bladder cancer (BC) is the 9th most common cancer worldwide, but little progress has been made in improving patient outcomes over the last 25 years. The King’s Health Partners (KHP) BC biobank was established ...

    Authors: Pinky Kotecha, Charlotte L. Moss, Deborah Enting, Cheryl Gillett, Magdalene Joseph, Debra Josephs, Sarah Rudman, Simon Hughes, Fidelma Cahill, Harriet Wylie, Anna Haire, James Rosekilly, Muhammad Shamin Khan, Rajesh Nair, Ramesh Thurairaja, Sachin Malde…

    Citation: BMC Cancer 2020 20:920

    Content type: Database

    Published on:

  2. A low level of methylation at cg05575921 in the aryl-hydrocarbon receptor repressor (AHRR) gene is robustly associated with smoking, and some studies have observed associations between cg05575921 methylation and ...

    Authors: Laurie Grieshober, Stefan Graw, Matt J. Barnett, Mark D. Thornquist, Gary E. Goodman, Chu Chen, Devin C. Koestler, Carmen J. Marsit and Jennifer A. Doherty

    Citation: BMC Cancer 2020 20:905

    Content type: Research article

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  3. The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the long-term all-cause mortality in TC survivors compared ...

    Authors: Elena Izkhakov, Lital Keinan-Boker, Micha Barchana, Yacov Shacham, Iris Yaish, Narin N. Carmel Neiderman, Dan M. Fliss, Naftali Stern and Joseph Meyerovitch

    Citation: BMC Cancer 2020 20:892

    Content type: Research article

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  4. Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutationa...

    Authors: Zhishan Chen, Wanqing Wen, Qiuyin Cai, Jirong Long, Ying Wang, Weiqiang Lin, Xiao-ou Shu, Wei Zheng and Xingyi Guo

    Citation: BMC Cancer 2020 20:880

    Content type: Research article

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  5. Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpos...

    Authors: Blanca Murillo-Ortiz, Abraham Hernández-Ramírez, Talia Rivera-Villanueva, David Suárez-García, Mario Murguía-Pérez, Sandra Martínez-Garza, Allyson Rodríguez-Penin, Rosario Romero-Coripuna and Xiomara Midory López-Partida

    Citation: BMC Cancer 2020 20:876

    Content type: Research article

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  6. Langerhans cell histiocytosis (LCH) affects 1–2 in 1,000,000 people. The disease is not associated with increased risk of treatment failure (especially among older children), but appropriate procedures impleme...

    Authors: Anna Raciborska, Katarzyna Bilska, Jadwiga Węcławek-Tompol, Olga Gryniewicz-Kwiatkowska, Małgorzata Hnatko-Kołacz, Joanna Stefanowicz, Anna Pieczonka, Katarzyna Jankowska, Filip Pierelejewski, Tomasz Ociepa, Grażyna Sobol-Milejska, Katarzyna Muszyńska-Rosłan, Olga Michoń, Wanda Badowska, Monika Radwańska and Katarzyna Drabko

    Citation: BMC Cancer 2020 20:874

    Content type: Research article

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  7. Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource settin...

    Authors: Gebretsadik Hailemariam, Hailay Gebreyesus, Tewolde Wubayehu, Tsgehana Gebregyorgis, Kidanemariam Gebrecherkos, Mebrahtu Teweldemedhin and Manaye Kifle

    Citation: BMC Cancer 2020 20:858

    Content type: Research article

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  8. Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physi...

    Authors: Thomas M. Schwedhelm, Judy R. Rees, Tracy Onega, Ronnie J. Zipkin, Andrew Schaefer, Maria O. Celaya and Erika L. Moen

    Citation: BMC Cancer 2020 20:847

    Content type: Research article

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  9. It is essential to have information on the disease burden of lung cancer at an individual level throughout the life; however, few such results have been reported. Thus, this study aimed to assess the lifetime ...

    Authors: Hae-Young Park, Jinseub Hwang, Do-Hyang Kim, Soo Min Jeon, Sun Ha Choi and Jin-Won Kwon

    Citation: BMC Cancer 2020 20:846

    Content type: Research article

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  10. Our objective was to assess racial differences in the 5-year relative survival rates (RSRs) of Cervical Cancer (CerCancer) by stage at diagnosis, between Black and White women, living in Alabama, USA.

    Authors: Ehsan Abdalla, Roberta Troy, Souleymane Fall, Isra Elhussin, Oyoyo Egiebor-Aiwan and David Nganwa

    Citation: BMC Cancer 2020 20:830

    Content type: Research article

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  11. Pesticide exposure is a suspected risk factor for childhood cancer. We investigated the risk of developing childhood cancer in relation to parental occupational exposure to pesticides in Switzerland for the pe...

    Authors: Astrid Coste, Helen D. Bailey, Mutlu Kartal-Kaess, Raffaele Renella, Aurélie Berthet and Ben D. Spycher

    Citation: BMC Cancer 2020 20:819

    Content type: Research article

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  12. In 2013, Jinan KingMed Diagnostics (JKD) first established a systematic cervical cytology training and quality control (QC) program in Shandong Province, China. We compared the efficacy of high-risk human papi...

    Authors: Dongman Zhao, Liran Zhang, Fengxiang Xie, Dezhi Peng, Jie Wei, Lingbo Jiang, Shoudu Zhang and Debo Qi

    Citation: BMC Cancer 2020 20:810

    Content type: Research article

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  13. In recent years, lung cancer (LC) incidence has increased in Iran. The use of opium and its derivatives (O&D) has increased as well. This study aimed to investigate the association between the use of O&D and L...

    Authors: Ahmad Naghibzadeh-Tahami, Maryam Marzban, Vahid Yazdi-Feyzabadi, Shahryar Dabiri, Shokrollah Mohseni, Reza Abbasi Rayeni, Mitra Samareh Fekri, Mohammad Hasan Larizadeh, Behnaz Karimpour and Narges Khanjani

    Citation: BMC Cancer 2020 20:807

    Content type: Research article

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  14. Many antipsychotics elevate prolactin, a hormone implicated in breast cancer aetiology however no studies have investigated antipsychotic use in patients with breast cancer. This study investigated if antipsyc...

    Authors: Blánaid M. Hicks, John Busby, Ken Mills, Francis A. O’Neil, Stuart A. McIntosh, Shu-Dong Zhang, Fabio Giuseppe Liberante and Chris R. Cardwell

    Citation: BMC Cancer 2020 20:804

    Content type: Research article

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  15. In the scope of the European Commission Initiative on Breast Cancer (ECIBC) the Monitoring and Evaluation (M&E) subgroup was tasked to identify breast cancer screening programme (BCSP) performance indicators, ...

    Authors: Sergei Muratov, Carlos Canelo-Aybar, Jean-Eric Tarride, Pablo Alonso-Coello, Nadya Dimitrova, Bettina Borisch, Xavier Castells, Stephen W. Duffy, Patricia Fitzpatrick, Markus Follmann, Livia Giordano, Solveig Hofvind, Annette Lebeau, Cecily Quinn, Alberto Torresin, Claudia Vialli…

    Citation: BMC Cancer 2020 20:795

    Content type: Research article

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  16. Angiosarcomas (AS) have poor prognosis and often metastasize to distant sites. The potential predictors of metastatic angiosarcomas (MAS) have not been extensively investigated. The main objective of this stud...

    Authors: Shihong Ren, Yucheng Wang, Zhan Wang, Jinxiang Shao and Zhaoming Ye

    Citation: BMC Cancer 2020 20:778

    Content type: Research article

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  17. Leukotriene receptor antagonists (LTRAs) are broadly used for the management of allergic asthma and have recently been indicated to inhibit carcinogenesis and cancer cell growth. In colorectal cancer (CRC) che...

    Authors: Takuma Higurashi, Jun Arimoto, Keiichi Ashikari, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo and Atsushi Nakajima

    Citation: BMC Cancer 2020 20:770

    Content type: Study protocol

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  18. Few studies have examined gender differences in the clinical management of rectal cancer. We examine differences in stage at diagnosis and preoperative radiotherapy in rectal cancer patients.

    Authors: Cristina Sarasqueta, Mª Victoria Zunzunegui, José María Enríquez Navascues, Arrate Querejeta, Carlos Placer, Amaia Perales, Nerea Gonzalez, Urko Aguirre, Marisa Baré, Antonio Escobar and José María Quintana

    Citation: BMC Cancer 2020 20:759

    Content type: Research article

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  19. Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-relat...

    Authors: Nadine Houédé, Xavier Rébillard, Sophie Bouvet, Sarah Kabani, Pascale Fabbro-Peray, Brigitte Trétarre and Florence Ménégaux

    Citation: BMC Cancer 2020 20:757

    Content type: Research article

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  20. The present study was conducted to determine the trend and projection of premature mortality from gastrointestinal cancers (GI cancers) at national and subnational levels in Iran.

    Authors: Fatemeh Khosravi Shadmani, Farshad Farzadfar, Moein Yoosefi, Kamyar Mansori, Reza Khosravi Shadman and Aliakbar Haghdoost

    Citation: BMC Cancer 2020 20:752

    Content type: Research article

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  21. Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. Definitions of the duration of the postpartum period have been controversi...

    Authors: Chunchun Shao, Zhigang Yu, Juan Xiao, Liyuan Liu, Fanzhen Hong, Yuan Zhang and Hongying Jia

    Citation: BMC Cancer 2020 20:746

    Content type: Research article

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  22. Precision oncology pharmacotherapy relies on precise patient-specific alterations that impact drug responses. Due to rapid advances in clinical tumor sequencing, an urgent need exists for a clinical support to...

    Authors: Quan Xu, Jin-Cheng Zhai, Cai-Qin Huo, Yang Li, Xue-Jiao Dong, Dong-Fang Li, Ru-Dan Huang, Chuang Shen, Yu-Jun Chang, Xi-Ling Zeng, Fan-Lin Meng, Fang Yang, Wan-Ling Zhang, Sheng-Nan Zhang, Yi-Ming Zhou and Zhi Zhang

    Citation: BMC Cancer 2020 20:740

    Content type: Software

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  23. Cancer-related fatigue represents one major cause of reduced quality of life in cancer patients and can seriously affect the physical, emotional, and cognitive functioning impeding coping with the disease. Opt...

    Authors: Ben Schöttker, Sabine Kuznia, Dana Clarissa Laetsch, David Czock, Annette Kopp-Schneider, Reiner Caspari and Hermann Brenner

    Citation: BMC Cancer 2020 20:739

    Content type: Study protocol

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  24. Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes.

    Authors: Limei Xu, Xiuju Wang, Xueyi Pan, Xiaotao Wang, Qing Wang, Bingyi Wu, Jiahui Cai, Ying Zhao, Lijuan Chen, Wuping Li and Juan Li

    Citation: BMC Cancer 2020 20:737

    Content type: Research article

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  25. The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look f...

    Authors: Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén and Maria Gardberg

    Citation: BMC Cancer 2020 20:710

    Content type: Research article

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  26. Cervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is n...

    Authors: Getnet Tesfaw, Yesuf Ahmed, Lealem Gedefaw, Lamessa Dube, Samson Godu, Kirubel Eshetu, Mesfin Nigussie, Haftamu Hailekiros, Moses Joloba, Gelila Goba and Alemseged Abdissa

    Citation: BMC Cancer 2020 20:706

    Content type: Research article

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  27. Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific ...

    Authors: Achraf El Asri, Btissame Zarrouq, Khaoula El Kinany, Laila Bouguenouch, Karim Ouldim and Karima El Rhazi

    Citation: BMC Cancer 2020 20:696

    Content type: Review

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  28. The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic mode...

    Authors: Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft, Susan E. Hankinson, A. Heather Eliassen, Jaime E. Hart, Francine Laden and Rulla M. Tamimi

    Citation: BMC Cancer 2020 20:695

    Content type: Research article

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  29. To identify modifiable risk factors that contribute to cancer holds important public health relevance for setting up prevention strategies. Therefore, the aim of this study was to estimate the proportion of ca...

    Authors: Leandro F. M. Rezende, Eliana Murata, Beatriz Giannichi, Luciana Yuki Tomita, Gabriela Arantes Wagner, Zila M. Sanchez, Carlos Celis-Morales and Gerson Ferrari

    Citation: BMC Cancer 2020 20:693

    Content type: Research article

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  30. There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identif...

    Authors: Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans and David P. French

    Citation: BMC Cancer 2020 20:680

    Content type: Research article

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  31. The incidence of anal squamous cell carcinoma (SCC) has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and ep...

    Authors: Yong Lu, Xiaohao Wang, Peiyang Li, Tao Zhang, Jiaming Zhou, Yufeng Ren, Yi Ding, Haihua Peng, Qichun Wei, Kaiyun You, Jason J. Ong, Christopher K. Fairley, Andrew E. Grulich, Meijin Huang, Yuanhong Gao and Huachun Zou

    Citation: BMC Cancer 2020 20:679

    Content type: Research article

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  32. Targeted treatment with Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) is superior to systemic chemotherapy in non-small cell lung cancer (NSCLC) patients with EGFR gene mutations. Dete...

    Authors: Phyu Sin Aye, Sandar Tin Tin, Mark James McKeage, Prashannata Khwaounjoo, Alana Cavadino and J. Mark Elwood

    Citation: BMC Cancer 2020 20:658

    Content type: Research article

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  33. Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase popul...

    Authors: Riina Aarnio, Ellinor Östensson, Matts Olovsson, Inger Gustavsson and Ulf Gyllensten

    Citation: BMC Cancer 2020 20:645

    Content type: Research article

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  34. For the first time, we present regional-level cancer incidence and world-standardized mortality rates for cancers for Martinique, Guadeloupe and French Guiana.

    Authors: Clarisse Joachim, Jacqueline Véronique-Baudin, Laure Desroziers, Édouard Chatignoux, Sophie Belliardo, Juliette Plenet, Jonathan Macni, Stephen Ulric-Gervaise, Jessica Peruvien, Bernard Bhakkan-Mambir and Jacqueline Deloumeaux

    Citation: BMC Cancer 2020 20:643

    Content type: Research article

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  35. Many studies have found that use of aspirin can lengthen survival in patients with gastrointestinal cancer. The aim of this study was to assess the survival benefit of aspirin use compared with non-aspirin use...

    Authors: Ju-Li Lin, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin and Chang-Ming Huang

    Citation: BMC Cancer 2020 20:638

    Content type: Research article

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  36. The incidence of thyroid cancer is increasing worldwide. This is not accompanied by a corresponding increase in mortality. In contrast, in most populations’ thyroid cancer mortality has been decreasing in rece...

    Authors: Enrique López Gavilanez, Noemí Bautista Litardo, Manuel Navarro Chávez, Mario Hernández Bonilla and Angel Segale Bajaña

    Citation: BMC Cancer 2020 20:637

    Content type: Correspondence

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  37. Sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Epidemiological studies on sarcoma from Australia are lacking, as previous studies have focused on a sarcoma type (e.g. soft t...

    Authors: Cameron M. Wright, Georgia Halkett, Richard Carey Smith and Rachael Moorin

    Citation: BMC Cancer 2020 20:625

    Content type: Research article

    Published on:

  38. The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, m...

    Authors: Seri Jeong, Seom Gim Kong, Da Jung Kim, Sangjin Lee and Ho Sup Lee

    Citation: BMC Cancer 2020 20:623

    Content type: Research article

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  39. Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibilit...

    Authors: Lidia Delrieu, Amélie Anota, Olivier Trédan, Damien Freyssenet, Aurélia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Béatrice Fervers, Vincent Pialoux, David Pérol and Olivia Pérol

    Citation: BMC Cancer 2020 20:622

    Content type: Study protocol

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  40. Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the...

    Authors: Sivan Shamai, Zach Rozenbaum, Ofer Merimsky, Matthew Derakhshesh, Yonatan Moshkovits, Joshua Arnold, Yan Topilsky, Yaron Arbel and Michal Laufer-Perl

    Citation: BMC Cancer 2020 20:609

    Content type: Research article

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  41. Since body mass index (BMI) is a convincing risk factor for breast cancer, it is speculated to be associated with lymph node metastasis. However, epidemiological studies are inconclusive. Therefore, this study...

    Authors: Junyi Wang, Yaning Cai, Fangfang Yu, Zhiguang Ping and Li Liu

    Citation: BMC Cancer 2020 20:601

    Content type: Research article

    Published on:

  42. We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male p...

    Authors: Jin Bong Choi, Jun-Pyo Myong, Yunhee Lee, Inah Kim, Jung Ho Kim, Sung-Hoo Hong and U-Syn Ha

    Citation: BMC Cancer 2020 20:589

    Content type: Research article

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  43. In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more fre...

    Authors: David P. French, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Anthony Howell, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Lorna McWilliams, Katherine Payne…

    Citation: BMC Cancer 2020 20:570

    Content type: Study protocol

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  44. Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This stu...

    Authors: Friederike Ruddies, Muluken Gizaw, Brhanu Teka, Sarah Thies, Andreas Wienke, Andreas M. Kaufmann, Tamrat Abebe, Adamu Addissie and Eva Johanna Kantelhardt

    Citation: BMC Cancer 2020 20:563

    Content type: Research article

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  45. Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening...

    Authors: Michael Lake, Christine S. Shusted, Hee-Soon Juon, Russell K. McIntire, Charnita Zeigler-Johnson, Nathaniel R. Evans, Gregory C. Kane and Julie A. Barta

    Citation: BMC Cancer 2020 20:561

    Content type: Research article

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