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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex. The aim of this study was t...

    Authors: Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi and Mounir Trimeche

    Citation: BMC Cancer 2018 18:49

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  2. Content type: Research article

    Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activati...

    Authors: Haiyan Song and Yuxiang Zhang

    Citation: BMC Cancer 2018 18:36

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  3. Content type: Research article

    Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to ...

    Authors: Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li and Yang-Sook Chun

    Citation: BMC Cancer 2018 18:30

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  4. Content type: Research article

    Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B parti...

    Authors: Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang

    Citation: BMC Cancer 2018 18:27

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  5. Content type: Research article

    The Grainyhead-like (GRHL) transcription factors have been linked to many different types of cancer. However, no previous study has attempted to investigate potential correlations in expression of different GRHL ...

    Authors: Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski and Tomasz Wilanowski

    Citation: BMC Cancer 2018 18:23

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  6. Content type: Research article

    Regulated cell death (RCD) is a mechanism by which the cell activates its own machinery to self-destruct. RCD is important for the maintenance of tissue homeostasis and its deregulation is involved in diseases...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina and Cristina Rodríguez-Padilla

    Citation: BMC Cancer 2018 18:13

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  7. Content type: Research article

    Currently, some studies have demonstrated that miR-34a could serve as a suppressor of several cancers including hepatocellular carcinoma (HCC). Previously, we discovered that miR-34a was downregulated in HCC a...

    Authors: Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen and Dian-Zhong Luo

    Citation: BMC Cancer 2018 18:12

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  8. Content type: Research article

    Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangeme...

    Authors: María F. Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A. Rivas, Rosalía Cordo-Russo, Cecilia J. Proietti, Elmer A. Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H. Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G. Gercovich, Eduardo Cortese…

    Citation: BMC Cancer 2017 17:895

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  9. Content type: Research article

    Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver. We previously f...

    Authors: Li-Hsuan Huang, Hsin-Yun Chung and Hui-Min Su

    Citation: BMC Cancer 2017 17:890

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  10. Content type: Research article

    Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by inhibition of apoptosis resulting in...

    Authors: Marina Conde, Susanne Michen, Ralf Wiedemuth, Barbara Klink, Evelin Schröck, Gabriele Schackert and Achim Temme

    Citation: BMC Cancer 2017 17:889

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  11. Content type: Research article

    Chlorella vulgaris (ChV), a unicellular green algae has been reported to have anticancer and antioxidant effects. The aim of this study was to determine the chemopreventive effect of C...

    Authors: Khaizurin Tajul Arifin, Suhaniza Sulaiman, Suhana Md Saad, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah and Yasmin Anum Mohd Yusof

    Citation: BMC Cancer 2017 17:879

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  12. Content type: Research article

    Prostate is susceptible to infection and pro-inflammatory agents in a man’s whole life. Chronic inflammation might play important roles in the development and progression of prostate cancer. Mesenchymal stem c...

    Authors: Ke-Qin Yang, Yan Liu, Qing-Hua Huang, Ning Mo, Qing-Yun Zhang, Qing-Gui Meng and Ji-Wen Cheng

    Citation: BMC Cancer 2017 17:878

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  13. Content type: Research article

    The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and an...

    Authors: Yanjie Lu, Qian Xu, Yanzhen Zuo, Lei Liu, Shaochen Liu, Lei Chen, Kang Wang, Yuntao Lei, Xiangyang Zhao and Yuhong Li

    Citation: BMC Cancer 2017 17:875

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  14. Content type: Research article

    The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and...

    Authors: Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley and David W. Melton

    Citation: BMC Cancer 2017 17:864

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  15. Content type: Research article

    Primary liver cancer is a lethal malignancy with a high mortality worldwide. Currently, sorafenib is the most effective molecular-targeted drug against hepatocellular carcinoma (HCC). However, the sorafenib re...

    Authors: Yinzong Xiao, Lunquan Sun, Yongming Fu, Yan Huang, Rongrong Zhou, Xingwang Hu, Pengcheng Zhou, Jun Quan, Ning Li and Xue-Gong Fan

    Citation: BMC Cancer 2017 17:857

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  16. Content type: Research article

    Histone demethylase JARID1B plays several context dependent roles in epigenetic regulation of cellular differentiation in normal development and is highly expressed in multiple human cancers. The protein is a ...

    Authors: Łukasz Kuźbicki, Dariusz Lange, Agata Stanek-Widera and Barbara W. Chwirot

    Citation: BMC Cancer 2017 17:854

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  17. Content type: Research article

    Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR wi...

    Authors: Simone Keller, Julia Kneissl, Verena Grabher-Meier, Stefan Heindl, Jan Hasenauer, Dieter Maier, Julian Mattes, Peter Winter and Birgit Luber

    Citation: BMC Cancer 2017 17:845

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  18. Content type: Research article

    The role of Spalt-like gene-2 (SALL2) in tumorigenesis remains incompletely elucidated. This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.

    Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang

    Citation: BMC Cancer 2017 17:838

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  19. Content type: Research article

    Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and meta...

    Authors: Thao N. D. Pham, Bethany E. Perez White, Huiping Zhao, Fariborz Mortazavi and Debra A. Tonetti

    Citation: BMC Cancer 2017 17:832

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  20. Content type: Research article

    Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells...

    Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi and Aike Li

    Citation: BMC Cancer 2017 17:813

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  21. Content type: Research article

    Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cel...

    Authors: Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar and Mohamed Boudjelal

    Citation: BMC Cancer 2017 17:803

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  22. Content type: Research article

    As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can b...

    Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi and Jianxiang Wang

    Citation: BMC Cancer 2017 17:795

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  23. Content type: Research article

    Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human di...

    Authors: Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, Sebastian Meister, Marieta Toma, Ralf Wiedemuth, Achim Temme, Vladimir Novotny, Manfred P. Wirth, Michael Bachmann, Jens Pietzsch and Susanne Fuessel

    Citation: BMC Cancer 2017 17:790

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  24. Content type: Research article

    Retinoblastoma (Rb), the most common childhood intraocular malignant tumor, is reported to have cancer stem cells (CSCs) similar to other tumors. Our previous investigation in primary tumors identified the sma...

    Authors: Rohini M. Nair, Murali MS. Balla, Imran Khan, Ravi Kiran Reddy Kalathur, Paturu Kondaiah and Geeta K. Vemuganti

    Citation: BMC Cancer 2017 17:779

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  25. Content type: Research article

    The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 wa...

    Authors: Rodrigo Fernandes da Silva, Daniela Maira Cardozo, Gisele Olinto Libanio Rodrigues, Caroline Natânia de Souza-Araújo, Natacha Azussa Migita, Liliana Aparecida Lucci de Angelo Andrade, Sophie Derchain, José Andrés Yunes and Fernando Guimarães

    Citation: BMC Cancer 2017 17:756

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  26. Content type: Research article

    Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigati...

    Authors: Jie Li, Yuanhui Lai, Jieyi Ma, Yue Liu, Jiong Bi, Longjuan Zhang, Lianzhou Chen, Chen Yao, Weiming Lv, Guangqi Chang, Shenming Wang, Mao Ouyang and Wenjian Wang

    Citation: BMC Cancer 2017 17:745

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  27. Content type: Research article

    Altered expression of receptor tyrosine kinases (RTKs) is a major driver of growth and metastasis of cancers. Recepteur d’origine nantais (RON) receptor is a single-pass transmembrane RTK aberrantly expressed ...

    Authors: Soundararajan Krishnaswamy, Abdul Khader Mohammed, Gyanendra Tripathi, Majed S. Alokail and Nasser M. Al-Daghri

    Citation: BMC Cancer 2017 17:738

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  28. Content type: Research article

    Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer ...

    Authors: Tingting Wang, Xufang Chen, Weiwei Qiao, Lijun Kong, Daqing Sun and Zunling Li

    Citation: BMC Cancer 2017 17:719

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  29. Content type: Research article

    Widely established targeted therapies directed at triple negative breast cancer (TNBC) are missing. Classical chemotherapy remains the systemic treatment option. Cisplatin has been tested in TNBC but bears the...

    Authors: Katharina Gohr, Alexandra Hamacher, Laura H. Engelke and Matthias U. Kassack

    Citation: BMC Cancer 2017 17:711

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  30. Content type: Technical advance

    Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set...

    Authors: Henriette L. Lanz, Anthony Saleh, Bart Kramer, Junmei Cairns, Chee Ping Ng, Jia Yu, Sebastiaan J. Trietsch, Thomas Hankemeier, Jos Joore, Paul Vulto, Richard Weinshilboum and Liewei Wang

    Citation: BMC Cancer 2017 17:709

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  31. Content type: Research article

    PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin f...

    Authors: Heli Repo, Natalia Gurvits, Eliisa Löyttyniemi, Marjukka Nykänen, Minnamaija Lintunen, Henna Karra, Samu Kurki, Teijo Kuopio, Kati Talvinen, Mirva Söderström and Pauliina Kronqvist

    Citation: BMC Cancer 2017 17:705

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  32. Content type: Research article

    Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) ...

    Authors: Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen and Robert Gniadecki

    Citation: BMC Cancer 2017 17:675

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    The Correction to this article has been published in BMC Cancer 2018 18:111

  33. Content type: Research article

    Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated...

    Authors: Shanyang He, Bing Liao, Yalan Deng, Chang Su, Jiuling Tuo, Jun Liu, Shuzhong Yao and Lin Xu

    Citation: BMC Cancer 2017 17:673

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  34. Content type: Research article

    Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a ...

    Authors: Samantha S. Dykes, Joshua J. Steffan and James A. Cardelli

    Citation: BMC Cancer 2017 17:672

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  35. Content type: Research article

    Slug is a transcription factor that activates the epithelial–mesenchymal transition (EMT) process in cancer progression. The aim of our study was to evaluate the clinical significance ...

    Authors: Han Hee Lee, Sung Hak Lee, Kyo Young Song, Sae Jung Na, Joo Hyun O, Jae Myung Park, Eun Sun Jung, Myung-Gyu Choi and Cho Hyun Park

    Citation: BMC Cancer 2017 17:670

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  36. Content type: Research article

    Secreted clusterin (sCLU), a 75–80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and repr...

    Authors: Runsen Jin, Xingshi Chen, Dingpei Han, Xiaoying Luo and Hecheng Li

    Citation: BMC Cancer 2017 17:661

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  37. Content type: Technical advance

    Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and g...

    Authors: David C. Benjamin and Richard O. Hynes

    Citation: BMC Cancer 2017 17:660

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  38. Content type: Research article

    Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metast...

    Authors: Anja Reithmeier, Elena Panizza, Michael Krumpel, Lukas M. Orre, Rui M. M. Branca, Janne Lehtiö, Barbro Ek-Rylander and Göran Andersson

    Citation: BMC Cancer 2017 17:650

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  39. Content type: Research article

    FOXP3 has been discovered to be expressed in tumor cells and participate in the regulation of tumor behavior. Herein, we investigated the clinical relevance and biological significance of FOXP3 expression in h...

    Authors: Jie-Yi Shi, Li-Jie Ma, Ji-Wei Zhang, Meng Duan, Zhen-Bin Ding, Liu-Xiao Yang, Ya Cao, Jian Zhou, Jia Fan, Xiaoming Zhang, Ying-Jun Zhao, Xiao-Ying Wang and Qiang Gao

    Citation: BMC Cancer 2017 17:648

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  40. Content type: Research article

    Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.

    Authors: Yang An, Shuzhen Wang, Songlin Li, Lulu Zhang, Dayong Wang, Haojie Wang, Shibai Zhu, Wan Zhu, Yongqiang Li, Wenwu Chen, Shaoping Ji and Xiangqian Guo

    Citation: BMC Cancer 2017 17:639

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  41. Content type: Research article

    Gastric cancer (GC) accounts for the fourth most occurring malignancy and the third major cause of cancer death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis and progre...

    Authors: Jianxin Ye, Jinsheng Huang, Jie Xu, Qiang Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Yun Li and Xu Lin

    Citation: BMC Cancer 2017 17:626

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  42. Content type: Research article

    Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy meta...

    Authors: Natalí N. Guerrero-Vargas, Raful Navarro-Espíndola, Mara A. Guzmán-Ruíz, María del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M. Buijs and Carolina Escobar

    Citation: BMC Cancer 2017 17:625

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  43. Content type: Research article

    Breast cancer is the common cancer in China. In previous study, we determined that 3,6-dihydroxyflavone (3,6-DHF) increases miR-34a significantly in breast carcinogenesis, but the mechanism remains unclear.

    Authors: Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu and Mantian Mi

    Citation: BMC Cancer 2017 17:619

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  44. Content type: Research article

    The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate...

    Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo

    Citation: BMC Cancer 2017 17:617

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  45. Content type: Research article

    Due to the presence of both classical estrogen receptor (ERα) and another ER subtype (ERβ) in ovarian cancer, hormonal treatment is an attractive option. However, response to tamoxifen in ovarian cancer is mod...

    Authors: Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Yan Wang, Thomas H. Y. Leung, Stephanie S. Liu, Annie N. Y. Cheung and Hextan Y. S. Ngan

    Citation: BMC Cancer 2017 17:606

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