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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Colorectal cancer (CRC) is still a leading cause of death worldwide. Recent studies have pointed to an important role of microRNAs in carcinogenesis. Several microRNAs are described as aberrantly expressed in ...

    Authors: Danuta Sastre, João Baiochi, Ildercilio Mota de Souza Lima, Felipe Canto de Souza, Amanda Cristina Corveloni, Carolina Hassib Thomé, Vitor Marcel Faça, Josiane Lilian dos Santos Schiavinato, Dimas Tadeu Covas and Rodrigo Alexandre Panepucci

    Citation: BMC Cancer 2019 19:1239

    Content type: Research article

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  2. The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellu...

    Authors: Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten and Smrati Bhadauria

    Citation: BMC Cancer 2019 19:1236

    Content type: Research article

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  3. Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have es...

    Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An

    Citation: BMC Cancer 2019 19:1224

    Content type: Research article

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  4. Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invas...

    Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle and Claire M. Wells

    Citation: BMC Cancer 2019 19:1214

    Content type: Research article

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  5. Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and ot...

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:1211

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2019 19:1255

  6. Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression. However...

    Authors: Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning and Qingan Jia

    Citation: BMC Cancer 2019 19:1192

    Content type: Research article

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  7. The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...

    Authors: Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1183

    Content type: Research article

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  8. While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Authors: Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm and Claudia R. Ball

    Citation: BMC Cancer 2019 19:1181

    Content type: Research article

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  9. Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis i...

    Authors: Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi and Mingang Hao

    Citation: BMC Cancer 2019 19:1180

    Content type: Research article

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  10. Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one ...

    Authors: Wilson Eduardo Furlan Matos Alves, Murilo Bonatelli, Rozany Dufloth, Lígia Maria Kerr, Guilherme Freire Angotti Carrara, Ricardo Filipe Alves da Costa, Cristovam Scapulatempo-Neto, Daniel Tiezzi, René Aloísio da Costa Vieira and Céline Pinheiro

    Citation: BMC Cancer 2019 19:1173

    Content type: Research article

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  11. Luminal B cancers show much worse outcomes compared to luminal A. This present study aims to screen key lncRNAs and mRNAs correlated with luminal-B breast cancer.

    Authors: Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei and Ying-Ying Liu

    Citation: BMC Cancer 2019 19:1171

    Content type: Research article

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  12. Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not...

    Authors: Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui and Yongjun Mao

    Citation: BMC Cancer 2019 19:1160

    Content type: Research article

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  13. Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a t...

    Authors: Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu and Dingqun Bai

    Citation: BMC Cancer 2019 19:1159

    Content type: Research article

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  14. Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TO...

    Authors: Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen and Irina Gromova

    Citation: BMC Cancer 2019 19:1158

    Content type: Research article

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  15. Chronic stress is well known to promote tumor progression, however, little is known whether chronic stress-mediated regulation of osteoblasts contributes to the migration and invasion of metastatic cancer cells.

    Authors: Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu and Fan Deng

    Citation: BMC Cancer 2019 19:1142

    Content type: Research article

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  16. Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

    Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2019 19:1137

    Content type: Research article

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  17. Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4), which fail to differentiate to pre-spermatogonia (POU...

    Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell

    Citation: BMC Cancer 2019 19:1124

    Content type: Research article

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  18. Osteosarcoma (OS) is a malignancy of the bone that has no clearly identified prognostic factors for diagnosis. In this study, we evaluated the regulatory role of long non-coding RNA (lncRNA) ANCR on the migrat...

    Authors: Bo Liu, Hongyan Zhao, Lili Zhang and Xuefeng Shi

    Citation: BMC Cancer 2019 19:1112

    Content type: Research article

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  19. Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often...

    Authors: Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri and Eric W.-F. Lam

    Citation: BMC Cancer 2019 19:1106

    Content type: Research article

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  20. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu

    Citation: BMC Cancer 2019 19:1094

    Content type: Research article

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  21. Conflicting results have been reported on the influence of carbohydrates in breast cancer.

    Authors: Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1076

    Content type: Research article

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  22. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen

    Citation: BMC Cancer 2019 19:1075

    Content type: Research article

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  23. DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional g...

    Authors: Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi and Yueying Wang

    Citation: BMC Cancer 2019 19:1072

    Content type: Research article

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  24. Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain succes...

    Authors: Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu and Liping Cao

    Citation: BMC Cancer 2019 19:1053

    Content type: Research article

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  25. The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly fo...

    Authors: Qing Zhang, Jian-He Liu, Jing-Li Liu, Chun-Ting Qi, Lei Yan, Yu Chen and Qiang Yu

    Citation: BMC Cancer 2019 19:1044

    Content type: Research article

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  26. Androgens, through their own receptor, play a protective role on breast tumor development and progression and counterbalance estrogen-dependent growth stimuli which are intimately linked to breast carcinogenesis.

    Authors: Francesca De Amicis, Chiara Chiodo, Catia Morelli, Ivan Casaburi, Stefania Marsico, Rosalinda Bruno, Diego Sisci, Sebastiano Andò and Marilena Lanzino

    Citation: BMC Cancer 2019 19:1038

    Content type: Research article

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  27. SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC.

    Authors: Zusen Wang, Yongxing Li, Shixiong Zhan, Lu Zhang, Shun Zhang, Qian Tang, Miaomiao Li, Zhen Tan, Shiguo Liu and Xiaoming Xing

    Citation: BMC Cancer 2019 19:1037

    Content type: Research article

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  28. β-arrestin-2(Arr2) functions as an anti-apoptotic factor and affects cell proliferation, but its downstream molecular pathway in endometrial carcinoma (EC) is still unclear. This study aimed to investigate the...

    Authors: Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun and Jianliu Wang

    Citation: BMC Cancer 2019 19:1035

    Content type: Research article

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  29. The lack of predictive biomarkers or test systems contributes to high failure rates of systemic therapy in metastasized colorectal carcinoma, accounting for a still unfavorable prognosis. Here, we present an e...

    Authors: Steve Z. Martin, Daniel C. Wagner, Nina Hörner, David Horst, Hauke Lang, Katrin E. Tagscherer and Wilfried Roth

    Citation: BMC Cancer 2019 19:1030

    Content type: Research article

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  30. Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression...

    Authors: Zahra Bolandghamat Pour, Mitra Nourbakhsh, Kazem Mousavizadeh, Zahra Madjd, Seyedeh Sara Ghorbanhosseini, Zohreh Abdolvahabi, Zahra Hesari and Samira Ezzati Mobasser

    Citation: BMC Cancer 2019 19:1027

    Content type: Research article

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  31. The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verify...

    Authors: Elisabetta Bassi, Paola Perucca, Isabella Guardamagna, Ennio Prosperi, Lucia A. Stivala and Ornella Cazzalini

    Citation: BMC Cancer 2019 19:1013

    Content type: Research article

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  32. High level of reactive oxygen species (ROS) has been detected in almost all cancers, which make it become one of the best-characterized phenotypes in cancers. Though ROS plays an important role in tumors, the ...

    Authors: Xiangcheng Qing, Deyao Shi, Xiao Lv, Baichuan Wang, Songfeng Chen and Zengwu Shao

    Citation: BMC Cancer 2019 19:997

    Content type: Research article

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  33. This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis.

    Authors: Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari and Gaurav Kaithwas

    Citation: BMC Cancer 2019 19:996

    Content type: Research article

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  34. Long non coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are not translated into proteins, but regulate the transcription of genes involved in different cellular processes, including c...

    Authors: Maria Barton, Julia Santucci-Pereira, Olivia G. Vaccaro, Theresa Nguyen, Yanrong Su and Jose Russo

    Citation: BMC Cancer 2019 19:994

    Content type: Research article

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  35. The glutathione S-transferases (GSTs) are a superfamily of phase II detoxifying enzymes that inactivates a wide variety of potential carcinogens through glutathione conjugation. Polymorphic changes in the GST gen...

    Authors: Nada Albarakati, Dareen Khayyat, Asharf Dallol, Jaudah Al-Maghrabi and Taoufik Nedjadi

    Citation: BMC Cancer 2019 19:991

    Content type: Research article

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  36. Nicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha...

    Authors: Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang and Yulan Yan

    Citation: BMC Cancer 2019 19:976

    Content type: Research article

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  37. Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis. The lack of in vitro model...

    Authors: P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito and G. P. Tonini

    Citation: BMC Cancer 2019 19:970

    Content type: Research article

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  38. Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the...

    Authors: Lei Li, Shuai Zhang, Hao Li and Haiyan Chou

    Citation: BMC Cancer 2019 19:963

    Content type: Research article

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  39. HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 o...

    Authors: Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho and Chun-Chia Cheng

    Citation: BMC Cancer 2019 19:959

    Content type: Research article

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  40. We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of ...

    Authors: Pascaline Nguemgo Kouam, Günther A. Rezniczek, Irenäus A. Adamietz and Helmut Bühler

    Citation: BMC Cancer 2019 19:958

    Content type: Research article

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  41. Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts. ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and...

    Authors: Ka-Kui Chan, Esther Shuk-Ying Wong, Ivy Tsz-Lo Wong, Claire Ling-Yang Cheung, Oscar Gee-Wan Wong, Hextan Yuen-Sheung Ngan and Annie Nga-Yin Cheung

    Citation: BMC Cancer 2019 19:953

    Content type: Research article

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  42. Transcription-coupled nucleotide excision repair (TC-NER) plays a prominent role in the removal of DNA adducts induced by platinum-based chemotherapy reagents. Cockayne syndrome protein B (CSB), the master sen...

    Authors: Zhenbang Yang, Chunling Liu, Hongjiao Wu, Yuning Xie, Hui Gao and Xuemei Zhang

    Citation: BMC Cancer 2019 19:948

    Content type: Research article

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  43. The Foxo3 gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene. Circ-Foxo3

    Authors: Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian and Zhao-Qun Deng

    Citation: BMC Cancer 2019 19:930

    Content type: Research article

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