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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remai...

    Authors: Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang and Yueming Sun

    Citation: BMC Cancer 2019 19:576

    Content type: Research article

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  2. Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of c...

    Authors: Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii and Joel A. Malek

    Citation: BMC Cancer 2019 19:565

    Content type: Research article

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  3. Over-expression of cyclooxygenase (COX)-2 promotes breast cancer progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined gene expression and microRNA microarray analyses of e...

    Authors: Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess and Peeyush K. Lala

    Citation: BMC Cancer 2019 19:561

    Content type: Research article

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  4. Sorting Nexin 27 (SNX27) belongs to a family of sortin nexins and possesses a unique binding domain at the C-terminus which mediates protein-protein interaction in intracellular trafficking, membrane remodelin...

    Authors: Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia and Jun Sun

    Citation: BMC Cancer 2019 19:555

    Content type: Research article

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  5. Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). How...

    Authors: Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi and Masamichi Mineshita

    Citation: BMC Cancer 2019 19:546

    Content type: Research article

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  6. The multi-functional BMCC1 (BCH motif-containing molecule at the carboxyl terminal region 1)/PRUNE2 plays a clear role in suppression of tumor activity. In the patients with neuroblastoma (NB), reduced express...

    Authors: Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara and Yasutoshi Tatsumi

    Citation: BMC Cancer 2019 19:542

    Content type: Research article

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  7. Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the mechanisms behind this effect are still unclear. Here we show that aerobic exercise in the form of chronic endurance tra...

    Authors: Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter and John Foley

    Citation: BMC Cancer 2019 19:536

    Content type: Research article

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  8. Homeobox A5 (HOXA5), a member of the HOX family, plays an important role in tumor development and morphogenesis, although opposite effects on tumorigenesis have been observed, depending on the tissue type. In ...

    Authors: Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan and Kensei Nishida

    Citation: BMC Cancer 2019 19:532

    Content type: Research article

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  11. Gastric cancer (GC) is one of the most common human cancers with the high rate of recurrence, metastasis and mortality. Aberrantly expressed microRNAs (miRNAs) are associated with invasion and metastasis in va...

    Authors: Yun Li, Xiaoli Yan, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin and Xu Lin

    Citation: BMC Cancer 2019 19:505

    Content type: Research article

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  12. Every biological experiment requires a choice of throughput balanced against physiological relevance. Most primary drug screens neglect critical parameters such as microenvironmental conditions, cell-cell hete...

    Authors: Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu and Erik S. Welf

    Citation: BMC Cancer 2019 19:502

    Content type: Technical advance

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  13. Cancer cells modify the balance between fatty acid (FA) synthesis and uptake under metabolic stress, induced by oxygen/nutrient deprivation. These modifications were shown to alter the levels of individual tri...

    Authors: Jan Lisec, Carsten Jaeger, Rida Rashid, Rimsha Munir and Nousheen Zaidi

    Citation: BMC Cancer 2019 19:501

    Content type: Research article

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  14. Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, whic...

    Authors: Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu and Yi Zhang

    Citation: BMC Cancer 2019 19:499

    Content type: Research article

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  15. Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known rol...

    Authors: Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson and Stephen P. Ethier

    Citation: BMC Cancer 2019 19:491

    Content type: Research article

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  16. Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expressio...

    Authors: Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro and Rosa Noguera

    Citation: BMC Cancer 2019 19:479

    Content type: Research article

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  17. Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in sev...

    Authors: Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka…

    Citation: BMC Cancer 2019 19:455

    Content type: Research article

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  18. Major vault protein (MVP) is the major component of vault, a eukaryotic organelle involved in multiple cellular processes, and is important in multiple cellular processes and diseases including the drug resist...

    Authors: Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben and Qi Chen

    Citation: BMC Cancer 2019 19:454

    Content type: Research article

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  19. Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We f...

    Authors: Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang and Shiguang Zhao

    Citation: BMC Cancer 2019 19:441

    Content type: Research article

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  20. Palliative pemetrexed-based chemotherapy remains a standard of care treatment for the majority of patients with advanced non-squamous non-small-cell lung cancer (NSCLC). Currently, no predictive markers for pe...

    Authors: S. Visser, J. Hou, K. Bezemer, L. L. de Vogel, J. P. J. J. Hegmans, B. H. Stricker, S. Philipsen and J. G. J. V. Aerts

    Citation: BMC Cancer 2019 19:440

    Content type: Research article

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  21. Dendritic cells (DCs) alter their role from being immunostimulatory to immunosuppressive at advanced stages of tumor progression, but the influence of cancer stem cells (CSCs) and their secreted factors on gen...

    Authors: Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che and Eiichi Gohda

    Citation: BMC Cancer 2019 19:439

    Content type: Research article

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  22. The SK-PN-DW cell line was established in 1979 and is commercially available. Despite the use of this cell line as an in vitro model for functional and therapeutic studies of malignant primitive neuroectoderma...

    Authors: Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu and Feng Wang

    Citation: BMC Cancer 2019 19:412

    Content type: Research article

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  23. CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, th...

    Authors: Isabelle Matte, Perrine Garde-Granger, Paul Bessette and Alain Piché

    Citation: BMC Cancer 2019 19:406

    Content type: Research article

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  24. Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. While these 3D-culture initiatives are already o...

    Authors: Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf and Mathias Hafner

    Citation: BMC Cancer 2019 19:402

    Content type: Research article

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  25. Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor ...

    Authors: Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen and Hongyu Yang

    Citation: BMC Cancer 2019 19:400

    Content type: Research article

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  26. The liver microenvironment plays a key role in the progression and metastasis of hepatocellular carcinoma (HCC). Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastati...

    Authors: Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv and Qingan Jia

    Citation: BMC Cancer 2019 19:395

    Content type: Research article

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  27. Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC...

    Authors: Jin-Yun Li, Wen-Xiao Huang, Xiao Zhou, Jie Chen and Zan Li

    Citation: BMC Cancer 2019 19:391

    Content type: Research article

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  28. Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the ...

    Authors: Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao and Yi Wang

    Citation: BMC Cancer 2019 19:381

    Content type: Research article

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  29. Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...

    Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa

    Citation: BMC Cancer 2019 19:356

    Content type: Research article

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  30. Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit

    Citation: BMC Cancer 2019 19:346

    Content type: Research article

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  31. Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

    Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen

    Citation: BMC Cancer 2019 19:343

    Content type: Research article

    Published on:

  33. Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the...

    Authors: Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin and Fa-Quan Lin

    Citation: BMC Cancer 2019 19:314

    Content type: Research article

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  34. The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer c...

    Authors: Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori and Martin Buess

    Citation: BMC Cancer 2019 19:312

    Content type: Research article

    Published on:

  35. Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involve...

    Authors: Rinako Miura, Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Miki Hashimura, Masataka Tochimoto, Sabine Kajita and Makoto Saegusa

    Citation: BMC Cancer 2019 19:308

    Content type: Research article

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  36. The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is assoc...

    Authors: Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson and Margreet C. M. Vissers

    Citation: BMC Cancer 2019 19:307

    Content type: Research article

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  37. Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-r...

    Authors: Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada and Yasushi Yoshimura

    Citation: BMC Cancer 2019 19:301

    Content type: Research article

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  38. Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been inve...

    Authors: Sophie Cowman, Yuen Ngan Fan, Barry Pizer and Violaine Sée

    Citation: BMC Cancer 2019 19:300

    Content type: Research article

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  41. The survival of OSCC patient needs to be further improved. miR-211 is oncogenic in OSCC and its upregulation is associated with tumor progression and poor patient survival. K14-EGFP-miR-211 transgenic mice also e...

    Authors: Yi-Fen Chen, Chung-Ji Liu, Li-Han Lin, Chung-Hsien Chou, Li-Yin Yeh, Shu-Chun Lin and Kuo-Wei Chang

    Citation: BMC Cancer 2019 19:281

    Content type: Research article

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  42. Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evalu...

    Authors: Liping Qiu, Hanlu Zheng and Xiaoying Zhao

    Citation: BMC Cancer 2019 19:273

    Content type: Research article

    Published on:

  43. Human papillomavirus (HPV) is an established risk factor for oropharyngeal squamous cell carcinoma (OSCC). The aim was to establish cell lines from HPV-positive tonsil carcinomas to be used for treatment devel...

    Authors: Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg and Lars Ekblad

    Citation: BMC Cancer 2019 19:265

    Content type: Research article

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  44. The immune system is a crucial component in cancer progression or regression. Molecular iodine (I2) exerts significant antineoplastic effects, acting as a differentiation inductor and immune modulator, but its ef...

    Authors: Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Cancer 2019 19:261

    Content type: Research article

    Published on:

  45. The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that function...

    Authors: Victoria J. Gennaro, Helen Wedegaertner and Steven B. McMahon

    Citation: BMC Cancer 2019 19:258

    Content type: Research article

    Published on:

  46. Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the p...

    Authors: Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas and Taosheng Chen

    Citation: BMC Cancer 2019 19:253

    Content type: Research article

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  47. Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells...

    Authors: Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui and Zhuo Chen

    Citation: BMC Cancer 2019 19:247

    Content type: Research article

    Published on:

  48. Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologi...

    Authors: Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou and Qi Song

    Citation: BMC Cancer 2019 19:240

    Content type: Research article

    Published on:

  49. Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr

    Citation: BMC Cancer 2019 19:234

    Content type: Research article

    Published on:

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