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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA in colorectal cancer (CRC). Although this microRNA is expressed in the early steps of...

    Authors: Lisa Perilli, Sofia Tessarollo, Laura Albertoni, Matteo Curtarello, Anna Pastò, Efrem Brunetti, Matteo Fassan, Massimo Rugge, Stefano Indraccolo, Alberto Amadori, Stefania Bortoluzzi and Paola Zanovello

    Citation: BMC Cancer 2019 19:821

    Content type: Research article

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  2. Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann

    Citation: BMC Cancer 2019 19:812

    Content type: Research article

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  3. Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of G...

    Authors: Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R. Broaddus, Ji Yeon Ahn, Jeong Mook Lim and Jae-Wook Jeong

    Citation: BMC Cancer 2019 19:810

    Content type: Research article

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  4. Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermine...

    Authors: Yin-Hsun Feng, Yu-Chu Su, Shuo-Fu Lin, Pey-Ru Lin, Chao-Liang Wu, Chao-Ling Tung, Chien-Feng Li, Gia-Shing Shieh and Ai-Li Shiau

    Citation: BMC Cancer 2019 19:791

    Content type: Research article

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  5. Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curativ...

    Authors: Becky A. S. Bibby, Cecelia S. Miranda, John V. Reynolds, Christopher J. Cawthorne and Stephen G. Maher

    Citation: BMC Cancer 2019 19:784

    Content type: Research article

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  6. Lung cancer in young patients is rare and has unique clinicopathological features. However, the molecular features of lung cancer in these patients are unclear. In this study, we aimed to describe the molecula...

    Authors: Zhen Chen, Xiao Teng, Jing Zhang, Ke Huang, Qian Shen, He Cao, Huisong Luo, Yanting Yuan and Xiaodong Teng

    Citation: BMC Cancer 2019 19:777

    Content type: Research article

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  7. The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a ...

    Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee and Jeung-Whan Han

    Citation: BMC Cancer 2019 19:773

    Content type: Research article

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  8. Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical application...

    Authors: Carla Pereira Gomes, Sandrina Nóbrega-Pereira, Beatriz Domingues-Silva, Kenny Rebelo, Catarina Alves-Vale, Sérgio Pires Marinho, Tânia Carvalho, Sérgio Dias and Bruno Bernardes de Jesus

    Citation: BMC Cancer 2019 19:771

    Content type: Research article

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  9. The role of sphere-forming culture in enriching subpopulations with stem-cell properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its value in enriching cancer stem cells (C...

    Authors: Xiao-Lu Ma, Yun-Fan Sun, Bei-Li Wang, Min-Na Shen, Yan Zhou, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Ya Cao, Bai-shen Pan, Jian Zhou, Jia Fan, Wei Guo and Xin-Rong Yang

    Citation: BMC Cancer 2019 19:760

    Content type: Research article

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  10. Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and su...

    Authors: Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh and Anna-Mart Engelbrecht

    Citation: BMC Cancer 2019 19:757

    Content type: Research article

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  12. Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...

    Authors: Lucía Barreno, Sara Cáceres, Ángela Alonso-Diez, Ana Vicente-Montaña, María Luisa García, Mónica Clemente, Juan Carlos Illera and Laura Peña

    Citation: BMC Cancer 2019 19:750

    Content type: Research article

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  13. Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progres...

    Authors: Jia-Wei Mei, Zi-Yi Yang, Hong-Gang Xiang, Runfa Bao, Yuan-Yuan Ye, Tai Ren, Xue-Feng Wang and Yi-Jun Shu

    Citation: BMC Cancer 2019 19:740

    Content type: Research article

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  14. Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer.

    Authors: Hui Wang, Zheqiong Tan, Hui Hu, Hongzhou Liu, Tangwei Wu, Chao Zheng, Xiuling Wang, Zhenzhao Luo, Jing Wang, Shuiyi Liu, Zhongxin Lu and Jiancheng Tu

    Citation: BMC Cancer 2019 19:738

    Content type: Research article

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  15. SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research...

    Authors: Hairu Yu, Jiayi Sun, Congxuan Zhao, Haotian Wang, Yeqiu Liu, Jiajia Xiong, Jing Chang, Mixue Wang, Wenhui Wang, Dongman Ye, Hongyan Zhou and Tao Yu

    Citation: BMC Cancer 2019 19:736

    Content type: Research article

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  16. Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). However, whether there is a crosstalk b...

    Authors: Qiang Zhou, Wei Zhang, Zhongfeng Wang and Songyang Liu

    Citation: BMC Cancer 2019 19:731

    Content type: Research article

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  17. Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the m...

    Authors: José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre and María de Jesús Ibarra-Sánchez

    Citation: BMC Cancer 2019 19:728

    Content type: Research article

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  18. Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.

    Authors: Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson and Matthew G. Vander Heiden

    Citation: BMC Cancer 2019 19:723

    Content type: Research article

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  19. Tongue squamous cell carcinoma (TSCC) is a special type of oral cancer. Cervical lymph node relapse may occur in a large percentage of TSCC patients, which usually indicates poor prognosis. In this cohort stud...

    Authors: Kailiu Wu, Junshui Wei, Zhengwu Liu, Binbin Yu, Xi Yang, Chunye Zhang, Ahmed Abdelrehem, Chenping Zhang and Siyi Li

    Citation: BMC Cancer 2019 19:714

    Content type: Research article

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  20. Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC pro...

    Authors: Lui Ng, Virginia Kwan, Ariel Chow, Thomas Chung-Cheung Yau, Ronnie Tung-Ping Poon, Roberta Pang and Wai-Lun Law

    Citation: BMC Cancer 2019 19:713

    Content type: Research article

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  21. Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expr...

    Authors: M.C. Casey, A. Prakash, E. Holian, A. McGuire, O. Kalinina, A. Shalaby, C. Curran, M. Webber, G. Callagy, E. Bourke, M. J. Kerin and J. A. Brown

    Citation: BMC Cancer 2019 19:712

    Content type: Research article

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  22. Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clini...

    Authors: Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng and Haozhe Piao

    Citation: BMC Cancer 2019 19:706

    Content type: Research article

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  24. Thyroid cancer is the most common endocrinology cancer that its incidence has increased in recent decades. miRNAs are new biomarkers in recent studies in the diagnosis and follow-up of these patients.

    Authors: Mahsa Rezaei, Amir Mahdi Khamaneh, Nosratollah Zarghami, Armin Vosoughi and Shahriar Hashemzadeh

    Citation: BMC Cancer 2019 19:690

    Content type: Research article

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  25. Re-capture of the differences between tumor and normal tissues observed at the patient level in cell cultures and animal models is critical for applications of these cancer-related differences. The epithelial-...

    Authors: Jing Song, Wenqing Wang, Yingyan Wang, Yongxin Qin, Yingzi Wang, Jian Zhou, Xuelian Wang, Yi Zhang and Qi Wang

    Citation: BMC Cancer 2019 19:680

    Content type: Research article

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  26. Although the prognosis of chronic myeloid leukemia (CML) has dramatically improved, the pathogenesis of CML remains elusive. Studies have shown that sustained phosphorylation of AKT1 plays a crucial role in th...

    Authors: Xiaorong Liu, Huirong Mai, Hanfang Jiang, Zhihao Xing, Dong Peng, Yuan Kong, Chunqing Zhu and Yunsheng Chen

    Citation: BMC Cancer 2019 19:679

    Content type: Research article

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  27. In epithelial cells, tyrosine kinases induce tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which is responsible for the epithelial-mesenchymal transition (EMT). However, the precise me...

    Authors: Yunfeng Zhang, Liangzhang Sun, Xiao Gao, Aining Guo, Yan Diao and Yang Zhao

    Citation: BMC Cancer 2019 19:670

    Content type: Research article

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  28. Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of whi...

    Authors: Ana Martín-Pardillos, Ángeles Valls Chiva, Gemma Bande Vargas, Pablo Hurtado Blanco, Roberto Piñeiro Cid, Pedro J. Guijarro, Stefan Hümmer, Eva Bejar Serrano, Aitor Rodriguez-Casanova, Ángel Diaz-Lagares, Josep Castellvi, Samuel Miravet-Verde, Luis Serrano, María Lluch-Senar, Víctor Sebastian, Ana Bribian…

    Citation: BMC Cancer 2019 19:666

    Content type: Research article

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  29. Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However,...

    Authors: Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf and Mirle Schemionek

    Citation: BMC Cancer 2019 19:658

    Content type: Research article

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  30. Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it i...

    Authors: Yingjie Chen, Zhipeng Yang, Yingxue Wang, Juandong Wang and Chuanxin Wang

    Citation: BMC Cancer 2019 19:651

    Content type: Research article

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  31. DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA plo...

    Authors: Jing Xu, Ruolin Zhu, Lulu Fan, Shangqing Ge, Wei Wei, Xiaoqiu Li, Liangshan Da, Zhenya Jia, Zhiyan Zhao, Jie Ning, Jie Da, Wanren Peng, Kangsheng Gu and Guoping Sun

    Citation: BMC Cancer 2019 19:650

    Content type: Research article

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  32. Recently, long non-coding RNAs (lncRNAs) were considered as important gene expression regulators involving various biological processes. In this study, we explored the role of lncRNAs in the pathogenesis of ra...

    Authors: Ju-Mei Zhou, Rong Liang, Su-Yu Zhu, Hui Wang, Min Zou, Wei-Jing Zou and Shao-Lin Nie

    Citation: BMC Cancer 2019 19:647

    Content type: Research article

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  33. Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...

    Authors: Bin Liu, Xiaojie Huang, Yifang Li, Weiguo Liao, Mingyi Li, Yi Liu, Rongrong He, Du Feng, Runzhi Zhu and Hiroshi Kurihara

    Citation: BMC Cancer 2019 19:645

    Content type: Research article

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  34. Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...

    Authors: Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung and Wei-Qun Ding

    Citation: BMC Cancer 2019 19:642

    Content type: Research article

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  35. Globally, the incidence and mortality rates of gastric cancer are high, and its poor prognosis is closely related to tumor recurrence and metastasis. Therefore, the molecular mechanisms associated with the mig...

    Authors: Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi and Wensheng Qiu

    Citation: BMC Cancer 2019 19:630

    Content type: Research article

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  36. Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with g...

    Authors: Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio and Eugenio Zoni

    Citation: BMC Cancer 2019 19:627

    Content type: Research article

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  37. Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian...

    Authors: Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham and Yong Li

    Citation: BMC Cancer 2019 19:618

    Content type: Research article

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  38. Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need for understanding the molecular mechanism underlying the...

    Authors: Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo and Yiyan Lei

    Citation: BMC Cancer 2019 19:609

    Content type: Research article

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  39. The prognosis of bladder urothelial carcinoma (BLCA) varies greatly among patients, and conventional pathological predictors are generally inadequate and often inaccurate to predict the heterogeneous behavior ...

    Authors: Shuxiong Zeng, Anwei Liu, Lihe Dai, Xiaowen Yu, Zhensheng Zhang, Qiao Xiong, Jun Yang, Fei Liu, Jinshan Xu, Yongping Xue, Yinghao Sun and Chuanliang Xu

    Citation: BMC Cancer 2019 19:604

    Content type: Research article

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  40. NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development is remarkabl...

    Authors: Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx and Frans van Roy

    Citation: BMC Cancer 2019 19:598

    Content type: Research article

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  41. S100A8 and S100A9, two heterodimer-forming members of the S100 family, aberrantly express in a variety of cancer types. However, little is known about the mechanism that regulates S100A8/S100A9 co-expression i...

    Authors: Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He and Xueyuan Xiao

    Citation: BMC Cancer 2019 19:597

    Content type: Research article

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  42. Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate c...

    Authors: Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke and Ivar P. Gladhaug

    Citation: BMC Cancer 2019 19:596

    Content type: Research article

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  43. Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is ...

    Authors: Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao and Xiaofei Chen

    Citation: BMC Cancer 2019 19:585

    Content type: Research article

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  44. In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian c...

    Authors: Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula and Hanna Sallinen

    Citation: BMC Cancer 2019 19:584

    Content type: Research article

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  45. By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms.

    Authors: Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer and Jin-Xiong She

    Citation: BMC Cancer 2019 19:581

    Content type: Research article

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  46. Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remai...

    Authors: Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang and Yueming Sun

    Citation: BMC Cancer 2019 19:576

    Content type: Research article

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  47. Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of c...

    Authors: Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii and Joel A. Malek

    Citation: BMC Cancer 2019 19:565

    Content type: Research article

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  48. Over-expression of cyclooxygenase (COX)-2 promotes breast cancer progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined gene expression and microRNA microarray analyses of e...

    Authors: Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess and Peeyush K. Lala

    Citation: BMC Cancer 2019 19:561

    Content type: Research article

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  49. Sorting Nexin 27 (SNX27) belongs to a family of sortin nexins and possesses a unique binding domain at the C-terminus which mediates protein-protein interaction in intracellular trafficking, membrane remodelin...

    Authors: Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia and Jun Sun

    Citation: BMC Cancer 2019 19:555

    Content type: Research article

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  50. Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). How...

    Authors: Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi and Masamichi Mineshita

    Citation: BMC Cancer 2019 19:546

    Content type: Research article

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