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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Smurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein substrates. The multi-functional scaffold protein Connector enhancer of kinase suppressor of ras 2 ...

    Authors: Diana David, Arun Surendran, Jissa V. Thulaseedharan and Asha S. Nair

    Citation: BMC Cancer 2018 18:284

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  2. Content type: Research article

    Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi re...

    Authors: Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li and Xuejie Fei

    Citation: BMC Cancer 2018 18:255

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  3. Content type: Research article

    Angiogenesis is a process of formation of new blood vessels and is an important criteria demonstrated by cancer cells. Over a period of time, these cancer cells infect the other parts of the healthy body by a ...

    Authors: Shailima Rampogu, Ayoung Baek, Amir Zeb and Keun Woo Lee

    Citation: BMC Cancer 2018 18:264

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  4. Content type: Research article

    High-grade chondrosarcoma, which has a high incidence of local recurrence and pulmonary metastasis despite surgical resection, is associated with poor prognosis. Therefore, new and effective adjuvant therapies...

    Authors: Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi and Masashi Neo

    Citation: BMC Cancer 2018 18:263

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  5. Content type: Research article

    TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low s...

    Authors: Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang and Qun Wang

    Citation: BMC Cancer 2018 18:260

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  6. Content type: Research article

    In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers, drives AKT activity. Constitutive activation of the PI3K...

    Authors: Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès and Vincent Picco

    Citation: BMC Cancer 2018 18:249

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  7. Content type: Research article

    Paclitaxel (PTX) is a potent anti-cancer drug commonly used for the treatment of advanced breast cancer (BCA) and melanoma. Toll-like receptor 4 (TLR4) promotes the production of pro-inflammatory cytokines ass...

    Authors: Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee and Chanitra Thuwajit

    Citation: BMC Cancer 2018 18:231

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  8. Content type: Research article

    It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast st...

    Authors: Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström and Håkan Olsson

    Citation: BMC Cancer 2018 18:230

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  9. Content type: Research article

    Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion proteins, such as E-cadherin, and desmosomal proteins a...

    Authors: Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun and Valérie Lobjois

    Citation: BMC Cancer 2018 18:221

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  10. Content type: Research article

    MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosar...

    Authors: Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters and Janet M. Shipley

    Citation: BMC Cancer 2018 18:217

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  11. Content type: Research article

    Accumulating evidence suggest that autophagy plays a pivotal role in various anticancer therapies, including photodynamic therapy (PDT), acting as a pro-death or pro-survival mechanism in a context-dependent m...

    Authors: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab and Malgorzata Firczuk

    Citation: BMC Cancer 2018 18:210

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  12. Content type: Research article

    Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-a...

    Authors: Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira and Fabio Dall’Olio

    Citation: BMC Cancer 2018 18:198

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  13. Content type: Debate

    The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential f...

    Authors: Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger and Sabine Grösch

    Citation: BMC Cancer 2018 18:153

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  14. Content type: Research article

    Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in sever...

    Authors: Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand and Uwe Knippschild

    Citation: BMC Cancer 2018 18:140

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  15. Content type: Research article

    Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc...

    Authors: Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira and María Ana Duhagon

    Citation: BMC Cancer 2018 18:127

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  16. Content type: Research article

    Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers. Previous data indicates altered ER expressio...

    Authors: Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan and Syed Yousef Iftikhar

    Citation: BMC Cancer 2018 18:121

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  17. Content type: Research article

    Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited du...

    Authors: Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya and Mototsugu Oya

    Citation: BMC Cancer 2018 18:113

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  18. Content type: Technical advance

    The poor prognosis for glioblastoma patients is caused by the diffuse infiltrative growth pattern of the tumor. Therefore, the molecular and cellular processes underlying cell migration continue to be a major ...

    Authors: Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel and Heike Peterziel

    Citation: BMC Cancer 2018 18:103

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  19. Content type: Research article

    In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the cr...

    Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati and Sushanta K. Banerjee

    Citation: BMC Cancer 2018 18:99

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  20. Content type: Research article

    FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative rol...

    Authors: Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário and Humberto Miguel Garay-Malpartida

    Citation: BMC Cancer 2018 18:90

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  21. Content type: Research article

    One of the major challenges in soft tissue sarcomas is to identify factors that predict metastasis. AZGP1 is a potential biomarker of cancer progression, but its value in soft tissue sarcomas remains unknown. ...

    Authors: Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li and Jiafu Ji

    Citation: BMC Cancer 2018 18:89

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  22. Content type: Research article

    Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial–mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a i...

    Authors: San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:74

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  23. Content type: Research article

    RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not be...

    Authors: Jeffrey J. Heard, Ivy Phung, Mark I. Potes and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2018 18:69

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  24. Content type: Research article

    The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression...

    Authors: Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest and Deborah Bell-Pedersen

    Citation: BMC Cancer 2018 18:43

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    The Correction to this article has been published in BMC Cancer 2019 19:101

  25. Content type: Research article

    Around the world, cervical cancer is the fourth most common cancer among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers and therapeutic approaches, resp...

    Authors: Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu and Qing H. Meng

    Citation: BMC Cancer 2018 18:61

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  26. Content type: Research article

    Moesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through transductional signals sent to actin filaments by glycoproteins, such as podopla...

    Authors: Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski and Denise Tostes Oliveira

    Citation: BMC Cancer 2018 18:53

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  27. Content type: Research article

    Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatmen...

    Authors: Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram and Gopal C. Kundu

    Citation: BMC Cancer 2018 18:52

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  28. Content type: Research article

    Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex. The aim of this study was t...

    Authors: Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi and Mounir Trimeche

    Citation: BMC Cancer 2018 18:49

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  29. Content type: Research article

    Exosomes, small-membrane vesicles, are secreted by cells and include several types of proteins and nucleic acids. Exosomes transfer cellular information derived from donor cells and are involved in various phy...

    Authors: Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami and Yoshiyuki Rikitake

    Citation: BMC Cancer 2018 18:47

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  30. Content type: Research article

    Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activati...

    Authors: Haiyan Song and Yuxiang Zhang

    Citation: BMC Cancer 2018 18:36

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  31. Content type: Research article

    Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to ...

    Authors: Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li and Yang-Sook Chun

    Citation: BMC Cancer 2018 18:30

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  32. Content type: Research article

    Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B parti...

    Authors: Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang

    Citation: BMC Cancer 2018 18:27

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  33. Content type: Research article

    The Grainyhead-like (GRHL) transcription factors have been linked to many different types of cancer. However, no previous study has attempted to investigate potential correlations in expression of different GRHL ...

    Authors: Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski and Tomasz Wilanowski

    Citation: BMC Cancer 2018 18:23

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  34. Content type: Research article

    Regulated cell death (RCD) is a mechanism by which the cell activates its own machinery to self-destruct. RCD is important for the maintenance of tissue homeostasis and its deregulation is involved in diseases...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina and Cristina Rodríguez-Padilla

    Citation: BMC Cancer 2018 18:13

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  35. Content type: Research article

    Currently, some studies have demonstrated that miR-34a could serve as a suppressor of several cancers including hepatocellular carcinoma (HCC). Previously, we discovered that miR-34a was downregulated in HCC a...

    Authors: Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen and Dian-Zhong Luo

    Citation: BMC Cancer 2018 18:12

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  36. Content type: Research article

    Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangeme...

    Authors: María F. Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A. Rivas, Rosalía Cordo-Russo, Cecilia J. Proietti, Elmer A. Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H. Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G. Gercovich, Eduardo Cortese…

    Citation: BMC Cancer 2017 17:895

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  37. Content type: Research article

    Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver. We previously f...

    Authors: Li-Hsuan Huang, Hsin-Yun Chung and Hui-Min Su

    Citation: BMC Cancer 2017 17:890

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  38. Content type: Research article

    Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by inhibition of apoptosis resulting in...

    Authors: Marina Conde, Susanne Michen, Ralf Wiedemuth, Barbara Klink, Evelin Schröck, Gabriele Schackert and Achim Temme

    Citation: BMC Cancer 2017 17:889

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  39. Content type: Research article

    Chlorella vulgaris (ChV), a unicellular green algae has been reported to have anticancer and antioxidant effects. The aim of this study was to determine the chemopreventive effect of C...

    Authors: Khaizurin Tajul Arifin, Suhaniza Sulaiman, Suhana Md Saad, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah and Yasmin Anum Mohd Yusof

    Citation: BMC Cancer 2017 17:879

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  40. Content type: Research article

    Prostate is susceptible to infection and pro-inflammatory agents in a man’s whole life. Chronic inflammation might play important roles in the development and progression of prostate cancer. Mesenchymal stem c...

    Authors: Ke-Qin Yang, Yan Liu, Qing-Hua Huang, Ning Mo, Qing-Yun Zhang, Qing-Gui Meng and Ji-Wen Cheng

    Citation: BMC Cancer 2017 17:878

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  41. Content type: Research article

    The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and an...

    Authors: Yanjie Lu, Qian Xu, Yanzhen Zuo, Lei Liu, Shaochen Liu, Lei Chen, Kang Wang, Yuntao Lei, Xiangyang Zhao and Yuhong Li

    Citation: BMC Cancer 2017 17:875

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  42. Content type: Research article

    The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and...

    Authors: Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley and David W. Melton

    Citation: BMC Cancer 2017 17:864

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  43. Content type: Research article

    Primary liver cancer is a lethal malignancy with a high mortality worldwide. Currently, sorafenib is the most effective molecular-targeted drug against hepatocellular carcinoma (HCC). However, the sorafenib re...

    Authors: Yinzong Xiao, Lunquan Sun, Yongming Fu, Yan Huang, Rongrong Zhou, Xingwang Hu, Pengcheng Zhou, Jun Quan, Ning Li and Xue-Gong Fan

    Citation: BMC Cancer 2017 17:857

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  44. Content type: Research article

    Histone demethylase JARID1B plays several context dependent roles in epigenetic regulation of cellular differentiation in normal development and is highly expressed in multiple human cancers. The protein is a ...

    Authors: Łukasz Kuźbicki, Dariusz Lange, Agata Stanek-Widera and Barbara W. Chwirot

    Citation: BMC Cancer 2017 17:854

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