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BMC Cancer

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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    The prognostic significance of free cancer cells detected in peritoneal fluid at the time of rectal surgery remains unclear. A substantial number of patients will develop metastatic disease even with successfu...

    Authors: Christian Arstad, Paulo Refinetti, Annette Torgunrud Kristensen, Karl-Erik Giercksky and Per Olaf Ekstrøm

    Citation: BMC Cancer 2017 17:406

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  2. Content type: Research article

    Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new...

    Authors: Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Milind Javle, Rune Smaaland, Bjørnar Gilje and Oddmund Nordgård

    Citation: BMC Cancer 2017 17:390

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  3. Content type: Research article

    Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarg...

    Authors: Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson and Scott A. Coonrod

    Citation: BMC Cancer 2017 17:378

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  4. Content type: Research article

    In view of the fact that JS-K might regulate ubiquitin E3 ligase and that ubiquitin E3 ligase plays an important role in the mechanism of CRPC formation, the goal was to investigate the probable mechanism by w...

    Authors: Guobin Tan, Mingning Qiu, Lieqian Chen, Sai Zhang, Longzhi Ke and Jianjun Liu

    Citation: BMC Cancer 2017 17:376

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  5. Content type: Research article

    The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC). CSCs have been associated to tumor invasion, metastasis a...

    Authors: Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D’Incalci, Sergio Pecorelli, Enrico Sartori…

    Citation: BMC Cancer 2017 17:366

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  6. Content type: Research article

    Nearly 30% of clear cell renal cell carcinoma (ccRCC) patients present with metastasis at the time of diagnosis, and the prognosis for these patients is poor. Therefore, novel potential prognostic biomarkers a...

    Authors: Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye and Liping Xie

    Citation: BMC Cancer 2017 17:373

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  7. Content type: Research article

    The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 ge...

    Authors: Brent Voels, Liping Wang, Donald A. Sens, Scott H. Garrett, Ke Zhang and Seema Somji

    Citation: BMC Cancer 2017 17:369

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  8. Content type: Case report

    A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid,...

    Authors: Estelle Menu, Nathalie Beaufils, Fabrice Usseglio, Estelle Balducci, Marina Lafage Pochitaloff, Regis Costello and Jean Gabert

    Citation: BMC Cancer 2017 17:363

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  9. Content type: Research article

    Malignant melanoma (MM) is one of the high degree of malignancy and early prone to blood and lymph node metastasis. There is not cured for MM. Tan II A has been reported to reduce cancer cell proliferation. Bu...

    Authors: Xiaojing Li, Zhifeng Li, Xianping Li, Baoguo Liu and Zhijun Liu

    Citation: BMC Cancer 2017 17:357

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  10. Content type: Research article

    Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

    Authors: Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li and Dejuan Wang

    Citation: BMC Cancer 2017 17:360

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    The Erratum to this article has been published in BMC Cancer 2017 17:569

  11. Content type: Research article

    Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously ...

    Authors: Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen and Gunbjorg Svineng

    Citation: BMC Cancer 2017 17:350

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  12. Content type: Research article

    Colorectal cancer (CRC) is the second leading cause of cancer-related death in men and women. Systemic disease with metastatic spread to distant sites such as the liver reduces the survival rate considerably. ...

    Authors: Derya Bocuk, Alexander Wolff, Petra Krause, Gabriela Salinas, Annalen Bleckmann, Christina Hackl, Tim Beissbarth and Sarah Koenig

    Citation: BMC Cancer 2017 17:342

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  13. Content type: Research article

    Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche. In this study, we us...

    Authors: Karis Chin-Quee and Henry J. Donahue

    Citation: BMC Cancer 2017 17:324

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  14. Content type: Research article

    Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.

    Authors: Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck

    Citation: BMC Cancer 2017 17:319

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  15. Content type: Research article

    The molecular profiles of tumors may inform the selection of appropriate targeted therapies. Circulating tumor cells (CTCs) reflect the real-time status of tumor genotypes. CTCs exhibit high genetic heterogene...

    Authors: Yuurin Kondo, Kazuhiko Hayashi, Kazuyuki Kawakami, Yukari Miwa, Hiroshi Hayashi and Masakazu Yamamoto

    Citation: BMC Cancer 2017 17:311

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  16. Content type: Research article

    Glabridin (GLA), a major component extracted from licorice root, has anti-inflammatory and antioxidant activities, but few studies report its mechanism of inhibition of angiogenesis. This study was an extensio...

    Authors: Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li and Zhong Li

    Citation: BMC Cancer 2017 17:307

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  17. Content type: Research article

    MicroRNAs are non-coding RNAs which regulate a variety of cellular functions in the development of tumors. Among the numerous microRNAs, microRNA-30a (miR-30a) is thought to play an important role in the proce...

    Authors: Minghao Xie, Huabo Qin, Qianxin Luo, Qunsheng Huang, Xiaosheng He, Zihuan Yang, Ping Lan and Lei Lian

    Citation: BMC Cancer 2017 17:305

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