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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Primary liver cancer is a lethal malignancy with a high mortality worldwide. Currently, sorafenib is the most effective molecular-targeted drug against hepatocellular carcinoma (HCC). However, the sorafenib re...

    Authors: Yinzong Xiao, Lunquan Sun, Yongming Fu, Yan Huang, Rongrong Zhou, Xingwang Hu, Pengcheng Zhou, Jun Quan, Ning Li and Xue-Gong Fan

    Citation: BMC Cancer 2017 17:857

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  2. Content type: Research article

    Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR wi...

    Authors: Simone Keller, Julia Kneissl, Verena Grabher-Meier, Stefan Heindl, Jan Hasenauer, Dieter Maier, Julian Mattes, Peter Winter and Birgit Luber

    Citation: BMC Cancer 2017 17:845

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  3. Content type: Research article

    The role of Spalt-like gene-2 (SALL2) in tumorigenesis remains incompletely elucidated. This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.

    Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang

    Citation: BMC Cancer 2017 17:838

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  4. Content type: Research article

    Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and meta...

    Authors: Thao N. D. Pham, Bethany E. Perez White, Huiping Zhao, Fariborz Mortazavi and Debra A. Tonetti

    Citation: BMC Cancer 2017 17:832

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  5. Content type: Research article

    Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells...

    Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi and Aike Li

    Citation: BMC Cancer 2017 17:813

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  6. Content type: Research article

    Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cel...

    Authors: Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar and Mohamed Boudjelal

    Citation: BMC Cancer 2017 17:803

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  7. Content type: Research article

    As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can b...

    Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi and Jianxiang Wang

    Citation: BMC Cancer 2017 17:795

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  8. Content type: Research article

    Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human di...

    Authors: Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, Sebastian Meister, Marieta Toma, Ralf Wiedemuth, Achim Temme, Vladimir Novotny, Manfred P. Wirth, Michael Bachmann, Jens Pietzsch and Susanne Fuessel

    Citation: BMC Cancer 2017 17:790

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  9. Content type: Research article

    Retinoblastoma (Rb), the most common childhood intraocular malignant tumor, is reported to have cancer stem cells (CSCs) similar to other tumors. Our previous investigation in primary tumors identified the sma...

    Authors: Rohini M. Nair, Murali MS. Balla, Imran Khan, Ravi Kiran Reddy Kalathur, Paturu Kondaiah and Geeta K. Vemuganti

    Citation: BMC Cancer 2017 17:779

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  10. Content type: Research article

    The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 wa...

    Authors: Rodrigo Fernandes da Silva, Daniela Maira Cardozo, Gisele Olinto Libanio Rodrigues, Caroline Natânia de Souza-Araújo, Natacha Azussa Migita, Liliana Aparecida Lucci de Angelo Andrade, Sophie Derchain, José Andrés Yunes and Fernando Guimarães

    Citation: BMC Cancer 2017 17:756

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  11. Content type: Research article

    Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigati...

    Authors: Jie Li, Yuanhui Lai, Jieyi Ma, Yue Liu, Jiong Bi, Longjuan Zhang, Lianzhou Chen, Chen Yao, Weiming Lv, Guangqi Chang, Shenming Wang, Mao Ouyang and Wenjian Wang

    Citation: BMC Cancer 2017 17:745

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  12. Content type: Research article

    Altered expression of receptor tyrosine kinases (RTKs) is a major driver of growth and metastasis of cancers. Recepteur d’origine nantais (RON) receptor is a single-pass transmembrane RTK aberrantly expressed ...

    Authors: Soundararajan Krishnaswamy, Abdul Khader Mohammed, Gyanendra Tripathi, Majed S. Alokail and Nasser M. Al-Daghri

    Citation: BMC Cancer 2017 17:738

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  13. Content type: Research article

    Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer ...

    Authors: Tingting Wang, Xufang Chen, Weiwei Qiao, Lijun Kong, Daqing Sun and Zunling Li

    Citation: BMC Cancer 2017 17:719

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  14. Content type: Research article

    Widely established targeted therapies directed at triple negative breast cancer (TNBC) are missing. Classical chemotherapy remains the systemic treatment option. Cisplatin has been tested in TNBC but bears the...

    Authors: Katharina Gohr, Alexandra Hamacher, Laura H. Engelke and Matthias U. Kassack

    Citation: BMC Cancer 2017 17:711

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  15. Content type: Technical advance

    Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set...

    Authors: Henriette L. Lanz, Anthony Saleh, Bart Kramer, Junmei Cairns, Chee Ping Ng, Jia Yu, Sebastiaan J. Trietsch, Thomas Hankemeier, Jos Joore, Paul Vulto, Richard Weinshilboum and Liewei Wang

    Citation: BMC Cancer 2017 17:709

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  16. Content type: Research article

    PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin f...

    Authors: Heli Repo, Natalia Gurvits, Eliisa Löyttyniemi, Marjukka Nykänen, Minnamaija Lintunen, Henna Karra, Samu Kurki, Teijo Kuopio, Kati Talvinen, Mirva Söderström and Pauliina Kronqvist

    Citation: BMC Cancer 2017 17:705

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  17. Content type: Research article

    Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) ...

    Authors: Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen and Robert Gniadecki

    Citation: BMC Cancer 2017 17:675

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    The Correction to this article has been published in BMC Cancer 2018 18:111

  18. Content type: Research article

    Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a ...

    Authors: Samantha S. Dykes, Joshua J. Steffan and James A. Cardelli

    Citation: BMC Cancer 2017 17:672

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  19. Content type: Research article

    Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated...

    Authors: Shanyang He, Bing Liao, Yalan Deng, Chang Su, Jiuling Tuo, Jun Liu, Shuzhong Yao and Lin Xu

    Citation: BMC Cancer 2017 17:673

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  20. Content type: Research article

    Slug is a transcription factor that activates the epithelial–mesenchymal transition (EMT) process in cancer progression. The aim of our study was to evaluate the clinical significance ...

    Authors: Han Hee Lee, Sung Hak Lee, Kyo Young Song, Sae Jung Na, Joo Hyun O, Jae Myung Park, Eun Sun Jung, Myung-Gyu Choi and Cho Hyun Park

    Citation: BMC Cancer 2017 17:670

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  21. Content type: Research article

    Secreted clusterin (sCLU), a 75–80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and repr...

    Authors: Runsen Jin, Xingshi Chen, Dingpei Han, Xiaoying Luo and Hecheng Li

    Citation: BMC Cancer 2017 17:661

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  22. Content type: Technical advance

    Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and g...

    Authors: David C. Benjamin and Richard O. Hynes

    Citation: BMC Cancer 2017 17:660

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  23. Content type: Research article

    Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metast...

    Authors: Anja Reithmeier, Elena Panizza, Michael Krumpel, Lukas M. Orre, Rui M. M. Branca, Janne Lehtiö, Barbro Ek-Rylander and Göran Andersson

    Citation: BMC Cancer 2017 17:650

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  24. Content type: Research article

    FOXP3 has been discovered to be expressed in tumor cells and participate in the regulation of tumor behavior. Herein, we investigated the clinical relevance and biological significance of FOXP3 expression in h...

    Authors: Jie-Yi Shi, Li-Jie Ma, Ji-Wei Zhang, Meng Duan, Zhen-Bin Ding, Liu-Xiao Yang, Ya Cao, Jian Zhou, Jia Fan, Xiaoming Zhang, Ying-Jun Zhao, Xiao-Ying Wang and Qiang Gao

    Citation: BMC Cancer 2017 17:648

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  25. Content type: Research article

    Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.

    Authors: Yang An, Shuzhen Wang, Songlin Li, Lulu Zhang, Dayong Wang, Haojie Wang, Shibai Zhu, Wan Zhu, Yongqiang Li, Wenwu Chen, Shaoping Ji and Xiangqian Guo

    Citation: BMC Cancer 2017 17:639

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  26. Content type: Research article

    Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy meta...

    Authors: Natalí N. Guerrero-Vargas, Raful Navarro-Espíndola, Mara A. Guzmán-Ruíz, María del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M. Buijs and Carolina Escobar

    Citation: BMC Cancer 2017 17:625

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  27. Content type: Research article

    Gastric cancer (GC) accounts for the fourth most occurring malignancy and the third major cause of cancer death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis and progre...

    Authors: Jianxin Ye, Jinsheng Huang, Jie Xu, Qiang Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Yun Li and Xu Lin

    Citation: BMC Cancer 2017 17:626

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  28. Content type: Research article

    Breast cancer is the common cancer in China. In previous study, we determined that 3,6-dihydroxyflavone (3,6-DHF) increases miR-34a significantly in breast carcinogenesis, but the mechanism remains unclear.

    Authors: Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu and Mantian Mi

    Citation: BMC Cancer 2017 17:619

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  29. Content type: Research article

    The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate...

    Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo

    Citation: BMC Cancer 2017 17:617

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  30. Content type: Research article

    Due to the presence of both classical estrogen receptor (ERα) and another ER subtype (ERβ) in ovarian cancer, hormonal treatment is an attractive option. However, response to tamoxifen in ovarian cancer is mod...

    Authors: Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Yan Wang, Thomas H. Y. Leung, Stephanie S. Liu, Annie N. Y. Cheung and Hextan Y. S. Ngan

    Citation: BMC Cancer 2017 17:606

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  31. Content type: Research article

    Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an emerging oncolytic, Maraba...

    Authors: Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia and Trevor G. Shepherd

    Citation: BMC Cancer 2017 17:594

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  32. Content type: Research article

    The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic ...

    Authors: Johan Falkenius, Hemming Johansson, Rainer Tuominen, Marianne Frostvik Stolt, Johan Hansson and Suzanne Egyhazi Brage

    Citation: BMC Cancer 2017 17:584

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  33. Content type: Research article

    Opioid receptors have become increasingly implicated in cancer progression and long-term patient outcomes. However, the expression and significance of the κ-opioid receptor (KOR) in hepatocellular carcinoma (H...

    Authors: Dongtai Chen, Yonghua Chen, Yan Yan, Jiahao Pan, Wei Xing, Qiang Li and Weian Zeng

    Citation: BMC Cancer 2017 17:553

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  34. Content type: Research article

    Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However,...

    Authors: Dennis C. Harrer, Bianca Simon, Shin-ichiro Fujii, Kanako Shimizu, Ugur Uslu, Gerold Schuler, Kerstin F. Gerer, Stefanie Hoyer, Jan Dörrie and Niels Schaft

    Citation: BMC Cancer 2017 17:551

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  35. Content type: Research article

    During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representin...

    Authors: Lucia Sommerova, Eva Ondrouskova, Borivoj Vojtesek and Roman Hrstka

    Citation: BMC Cancer 2017 17:546

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  36. Content type: Research article

    Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this,...

    Authors: A. K. Pedersen, J. Mendes Lopes de Melo, N. Mørup, K. Tritsaris and S. F. Pedersen

    Citation: BMC Cancer 2017 17:542

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  37. Content type: Research article

    Real-time polymerase chain reaction (PCR) has become an increasingly important technique for gene expression profiling because it can provide insights into complex biological and pathological processes and be ...

    Authors: Xi Wu, Susu Liu, Jianjun Lyu, Shuya Zhou, Yanwei Yang, Chenfei Wang, Wenda Gu, Qin Zuo, Baowen Li and Changfa Fan

    Citation: BMC Cancer 2017 17:545

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  38. Content type: Research article

    Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts p...

    Authors: Iacovos P. Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E. Quaggin and Marie Jeansson

    Citation: BMC Cancer 2017 17:539

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  39. Content type: Research article

    Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alte...

    Authors: Khaoula Ben Younes, Simon Body, Élodie Costé, Pierre-Julien Viailly, Hadjer Miloudi, Clémence Coudre, Fabrice Jardin, Fatma Ben Aissa-Fennira and Brigitte Sola

    Citation: BMC Cancer 2017 17:538

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  40. Content type: Research article

    Insulin-like growth factors and insulin are important factors promoting cancer growth and metastasis. The molecules act through IGF1 (IGF1R) and insulin (InsR) receptors. Rhambodmyosarcomas (RMS) overproduce I...

    Authors: Maciej Tarnowski, Marta Tkacz, Katarzyna Zgutka, Joanna Bujak, Patrycja Kopytko and Andrzej Pawlik

    Citation: BMC Cancer 2017 17:532

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  41. Content type: Case report

    The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is parti...

    Authors: Caterina De Benedittis, Cristina Papayannidis, Claudia Venturi, Maria Chiara Abbenante, Stefania Paolini, Sarah Parisi, Chiara Sartor, Michele Cavo, Giovanni Martinelli and Simona Soverini

    Citation: BMC Cancer 2017 17:523

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  42. Content type: Research article

    The biological phenomenon of cell fusion has been associated with cancer progression since it was determined that normal cell × tumor cell fusion-derived hybrid cells could exhibit novel properties, such as en...

    Authors: Daria Gauck, Silvia Keil, Bernd Niggemann, Kurt S. Zänker and Thomas Dittmar

    Citation: BMC Cancer 2017 17:515

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  43. Content type: Technical advance

    The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres. These different...

    Authors: Averey D. Strong and Richard L. Daniels

    Citation: BMC Cancer 2017 17:516

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  44. Content type: Research article

    Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.

    Authors: Frank Jacobsen, Billurvan Taskin, Nathaniel Melling, Charlotte Sauer, Corinna Wittmer, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Dirk Pehrke, Burkhard Beyer, Thomas Steuber, Imke Thederan, Guido Sauter, Thorsten Schlomm, Waldemar Wilczak, Katharina Möller…

    Citation: BMC Cancer 2017 17:504

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  45. Content type: Research article

    Germline mutations in genes encoding subunits of succinate dehydrogenase (SDH) are associated with the development of pheochromocytoma (PC) and/or paraganglioma (PGL). As assembly factors have been identified ...

    Authors: Trisha Dwight, Un Na, Edward Kim, Ying Zhu, Anne Louise Richardson, Bruce G. Robinson, Katherine M. Tucker, Anthony J. Gill, Diana E. Benn, Roderick J. Clifton-Bligh and Dennis R. Winge

    Citation: BMC Cancer 2017 17:497

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  46. Content type: Research article

    Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM als...

    Authors: Qian Wang, Yu Cheng, Yan Wang, Yibo Fan, Ce Li, Ye Zhang, Yiding Wang, Qian Dong, Yanju Ma, Yue-e Teng, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2017 17:492

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