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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. The SK-PN-DW cell line was established in 1979 and is commercially available. Despite the use of this cell line as an in vitro model for functional and therapeutic studies of malignant primitive neuroectoderma...

    Authors: Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu and Feng Wang

    Citation: BMC Cancer 2019 19:412

    Content type: Research article

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  2. CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, th...

    Authors: Isabelle Matte, Perrine Garde-Granger, Paul Bessette and Alain Piché

    Citation: BMC Cancer 2019 19:406

    Content type: Research article

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  3. Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. While these 3D-culture initiatives are already o...

    Authors: Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf and Mathias Hafner

    Citation: BMC Cancer 2019 19:402

    Content type: Research article

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  4. Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor ...

    Authors: Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen and Hongyu Yang

    Citation: BMC Cancer 2019 19:400

    Content type: Research article

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  5. The liver microenvironment plays a key role in the progression and metastasis of hepatocellular carcinoma (HCC). Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastati...

    Authors: Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv and Qingan Jia

    Citation: BMC Cancer 2019 19:395

    Content type: Research article

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  6. Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC...

    Authors: Jin-Yun Li, Wen-Xiao Huang, Xiao Zhou, Jie Chen and Zan Li

    Citation: BMC Cancer 2019 19:391

    Content type: Research article

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  7. Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the ...

    Authors: Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao and Yi Wang

    Citation: BMC Cancer 2019 19:381

    Content type: Research article

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  8. Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...

    Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa

    Citation: BMC Cancer 2019 19:356

    Content type: Research article

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  9. Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit

    Citation: BMC Cancer 2019 19:346

    Content type: Research article

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  10. Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

    Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen

    Citation: BMC Cancer 2019 19:343

    Content type: Research article

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  12. Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the...

    Authors: Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin and Fa-Quan Lin

    Citation: BMC Cancer 2019 19:314

    Content type: Research article

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  13. The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer c...

    Authors: Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori and Martin Buess

    Citation: BMC Cancer 2019 19:312

    Content type: Research article

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  14. Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involve...

    Authors: Rinako Miura, Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Miki Hashimura, Masataka Tochimoto, Sabine Kajita and Makoto Saegusa

    Citation: BMC Cancer 2019 19:308

    Content type: Research article

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  15. The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is assoc...

    Authors: Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson and Margreet C. M. Vissers

    Citation: BMC Cancer 2019 19:307

    Content type: Research article

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  16. Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-r...

    Authors: Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada and Yasushi Yoshimura

    Citation: BMC Cancer 2019 19:301

    Content type: Research article

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  17. Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been inve...

    Authors: Sophie Cowman, Yuen Ngan Fan, Barry Pizer and Violaine Sée

    Citation: BMC Cancer 2019 19:300

    Content type: Research article

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  20. The survival of OSCC patient needs to be further improved. miR-211 is oncogenic in OSCC and its upregulation is associated with tumor progression and poor patient survival. K14-EGFP-miR-211 transgenic mice also e...

    Authors: Yi-Fen Chen, Chung-Ji Liu, Li-Han Lin, Chung-Hsien Chou, Li-Yin Yeh, Shu-Chun Lin and Kuo-Wei Chang

    Citation: BMC Cancer 2019 19:281

    Content type: Research article

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  21. Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evalu...

    Authors: Liping Qiu, Hanlu Zheng and Xiaoying Zhao

    Citation: BMC Cancer 2019 19:273

    Content type: Research article

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  22. Human papillomavirus (HPV) is an established risk factor for oropharyngeal squamous cell carcinoma (OSCC). The aim was to establish cell lines from HPV-positive tonsil carcinomas to be used for treatment devel...

    Authors: Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg and Lars Ekblad

    Citation: BMC Cancer 2019 19:265

    Content type: Research article

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  23. The immune system is a crucial component in cancer progression or regression. Molecular iodine (I2) exerts significant antineoplastic effects, acting as a differentiation inductor and immune modulator, but its ef...

    Authors: Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Cancer 2019 19:261

    Content type: Research article

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  24. The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that function...

    Authors: Victoria J. Gennaro, Helen Wedegaertner and Steven B. McMahon

    Citation: BMC Cancer 2019 19:258

    Content type: Research article

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  25. Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the p...

    Authors: Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas and Taosheng Chen

    Citation: BMC Cancer 2019 19:253

    Content type: Research article

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  26. Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells...

    Authors: Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui and Zhuo Chen

    Citation: BMC Cancer 2019 19:247

    Content type: Research article

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  27. Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologi...

    Authors: Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou and Qi Song

    Citation: BMC Cancer 2019 19:240

    Content type: Research article

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  28. Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr

    Citation: BMC Cancer 2019 19:234

    Content type: Research article

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  30. Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. AL...

    Authors: Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng and Claudio Luchini

    Citation: BMC Cancer 2019 19:232

    Content type: Research article

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  31. This study aimed to determine whether the enhancer of the rudimentary homolog (ERH) gene regulates cell migration and invasion in human bladder urothelial carcinoma (BUC) T24 cells and the underlying mechanism.

    Authors: Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han and Conghui Han

    Citation: BMC Cancer 2019 19:225

    Content type: Research article

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  32. Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX...

    Authors: Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao and Kai-qun Ren

    Citation: BMC Cancer 2019 19:224

    Content type: Research article

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  33. Previous studies have demonstrated that β2-microglobulin (β2M) promotes the growth and survival of a variety of cancer cells and has different regulatory effects on the expression of Bcl-2 and HER2 in HER2− breas...

    Authors: Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu and Xiaowen Lian

    Citation: BMC Cancer 2019 19:223

    Content type: Research article

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  34. The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The ...

    Authors: Qi Chen, Yueqin Liu, Xiao-lan Zhu, Fan Feng, Hui Yang and Wenlin Xu

    Citation: BMC Cancer 2019 19:211

    Content type: Research article

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  35. The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomi...

    Authors: Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas and Jaunius Urbonavičius

    Citation: BMC Cancer 2019 19:197

    Content type: Research article

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  36. Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based stud...

    Authors: Peter L. Labib, George Goodchild and Stephen P. Pereira

    Citation: BMC Cancer 2019 19:185

    Content type: Review

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  37. VEGF/VEGFR2 pathway is the central therapeutic target in anti-angiogenic treatment in multiple cancers. However, little work has been carried out concerning the pro-malignancy functions of VEGFR2 that are inde...

    Authors: Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou and Min Jiang

    Citation: BMC Cancer 2019 19:183

    Content type: Research article

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  38. Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following...

    Authors: Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews and Christopher Bradley

    Citation: BMC Cancer 2019 19:179

    Content type: Research article

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  39. Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits osteoclastogenesis. Emerging evidence suggests that ZA has anti-tumor and anti-metastatic properties for breast cancer cells. In a mouse mod...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen and Tsun-Mei Lin

    Citation: BMC Cancer 2019 19:176

    Content type: Research article

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  40. Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) ...

    Authors: Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu and Xipeng Wang

    Citation: BMC Cancer 2019 19:171

    Content type: Research article

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  41. Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utiliz...

    Authors: Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha and Patrick E. Chappell

    Citation: BMC Cancer 2019 19:158

    Content type: Research article

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  42. Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical impor...

    Authors: Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton and Sebastian G. B. Furness

    Citation: BMC Cancer 2019 19:157

    Content type: Research article

    Published on:

  43. Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells)....

    Authors: Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu

    Citation: BMC Cancer 2019 19:153

    Content type: Research article

    Published on:

  44. A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...

    Authors: Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim

    Citation: BMC Cancer 2019 19:148

    Content type: Research article

    Published on:

  45. Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...

    Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc

    Citation: BMC Cancer 2019 19:137

    Content type: Research article

    Published on:

  46. Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a...

    Authors: Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir

    Citation: BMC Cancer 2019 19:135

    Content type: Research article

    Published on:

  47. Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The...

    Authors: Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid and Fabian D. Mairinger

    Citation: BMC Cancer 2019 19:108

    Content type: Research article

    Published on:

  49. In this report we examine candidate pathways perturbed by Compound Kushen Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to alter the gene expression patterns of multiple p...

    Authors: Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang and David L. Adelson

    Citation: BMC Cancer 2019 19:103

    Content type: Research article

    Published on:

  50. Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and pro...

    Authors: Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma and Jian Lu

    Citation: BMC Cancer 2019 19:94

    Content type: Research article

    Published on:

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