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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a p...

    Authors: Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber and Simone Muenst

    Citation: BMC Cancer 2019 19:41

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  5. Content type: Research article

    We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on...

    Authors: Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee and Dae Seog Heo

    Citation: BMC Cancer 2019 19:19

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  6. Content type: Research article

    Gastric cancer (GC) is a common malignant disease worldwide. Aberrant miRNAs expression contributes to malignant cells behaviour, and in preclinical research, miRNA targeting has shown potential for improving ...

    Authors: Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu and Jianlin Ren

    Citation: BMC Cancer 2019 19:14

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  7. Content type: Research article

    Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ap...

    Authors: Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland and Anders Molven

    Citation: BMC Cancer 2019 19:11

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  8. Content type: Research article

    Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estroge...

    Authors: Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park and Eui-Ju Hong

    Citation: BMC Cancer 2019 19:6

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  9. Content type: Research article

    MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Ther...

    Authors: Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang and Xingsheng Yang

    Citation: BMC Cancer 2018 18:1294

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  10. Content type: Research article

    Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear...

    Authors: Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang and Huanzhou Xue

    Citation: BMC Cancer 2018 18:1286

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  11. Content type: Research article

    Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such...

    Authors: Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright and Mark D. Temple

    Citation: BMC Cancer 2018 18:1284

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  12. Content type: Research article

    Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic o...

    Authors: Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi and Rakesh K. Singh

    Citation: BMC Cancer 2018 18:1283

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  13. Content type: Research article

    Breast cancer is the most common malignancy in women affecting one out of eight females throughout their lives. Autotaxin (ATX) is upregulated in breast cancer which results in increased lysophosphatidic acid ...

    Authors: Rafael Schmid, Katharina Wolf, Jan W. Robering, Selina Strauß, Pamela L. Strissel, Reiner Strick, Matthias Rübner, Peter A. Fasching, Raymund E. Horch, Andreas E. Kremer, Anja M. Boos and Annika Weigand

    Citation: BMC Cancer 2018 18:1273

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  14. Content type: Research article

    We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the p...

    Authors: Yi Xu, Xiaoyu Yang, Di Gao, Liu Yang, Keith Miskimins and Steven Y. Qian

    Citation: BMC Cancer 2018 18:1268

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  15. Content type: Research article

    Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration. The aim of this study was to determine the effects of leptin on the antioxidant response in th...

    Authors: Sinda Mahbouli, Jérémie Talvas, Audrey der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson and Adrien Rossary

    Citation: BMC Cancer 2018 18:1264

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  16. Content type: Research article

    Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions. GR...

    Authors: Christopher N. Cultrara, Stephen D. Kozuch, Poornema Ramasundaram, Claudia J. Heller, Sunil Shah, Adah E. Beck, David Sabatino and Jenny Zilberberg

    Citation: BMC Cancer 2018 18:1263

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  17. Content type: Research article

    FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating...

    Authors: Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola and Ratna Chakrabarti

    Citation: BMC Cancer 2018 18:1257

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  18. Content type: Research article

    The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is character...

    Authors: Taoufik Nedjadi, Anthony Evans, Adnan Sheikh, Lawrence Barerra, Suliman Al-Ghamdi, Lucy Oldfield, W. Greenhalf, John P. Neoptolemos and Eithne Costello

    Citation: BMC Cancer 2018 18:1255

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  20. Content type: Research article

    Non-muscle invasive bladder cancers (NMIBC: pTa, pT1) are characterised by a high risk of recurrence and/or progression. Identification of prognostic markers is needed to improve both diagnosis and management ...

    Authors: Christel Mathis, Isabelle Lascombe, Franck Monnien, Hugues Bittard, François Kleinclauss, Isabelle Bedgedjian, Sylvie Fauconnet and Séverine Valmary-Degano

    Citation: BMC Cancer 2018 18:1239

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  21. Content type: Research article

    The current treatment of malignant melanoma is limited by the lack of effective therapeutic approaches, and alternative treatments are needed. Proliferative diseases such as melanoma and other cancers may be t...

    Authors: Marina Teras, Edda Viisileht, Merlis Pahtma-Hall, Airi Rump, Viiu Paalme, Pille Pata, Illar Pata, Christelle Langevin and Sirje Rüütel Boudinot

    Citation: BMC Cancer 2018 18:1237

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  22. Content type: Research article

    Curcumin, a primary active ingredient extracted from the Curcuma longa, has been recently identified as a potential anti-tumor agent in multiple kinds of cancers. However, the effect of curcumin on retinoblastoma...

    Authors: Yaping Li, Weixuan Sun, Ning Han, Ying Zou and Dexin Yin

    Citation: BMC Cancer 2018 18:1230

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  23. Content type: Research article

    Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression sig...

    Authors: Annabelle Monnier, Rachel Boniface, Régis Bouvet, Amandine Etcheverry, Marc Aubry, Tony Avril, Véronique Quillien, Eric Chevet and Jean Mosser

    Citation: BMC Cancer 2018 18:1213

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  24. Content type: Research article

    Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are ...

    Authors: Juri Ogishima, Ayumi Taguchi, Akira Kawata, Kei Kawana, Mitsuyo Yoshida, Yuki Yoshimatsu, Masakazu Sato, Hiroe Nakamura, Yoshiko Kawata, Akira Nishijima, Asaha Fujimoto, Kensuke Tomio, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Tohru Kiyono…

    Citation: BMC Cancer 2018 18:1201

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  25. Content type: Research article

    Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes depende...

    Authors: Diana Andrejeva, Jan-Michael Kugler, Hung Thanh Nguyen, Anders Malmendal, Mette Lind Holm, Birgitte Groenkaer Toft, Anand C. Loya and Stephen M. Cohen

    Citation: BMC Cancer 2018 18:1180

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  26. Content type: Research article

    The dysregulation of miR-663a is frequently observed in many human cancers. However, the functional role and precise mechanism of miR-663a have been controversial in hepatocellular carcinoma (HCC) and need to ...

    Authors: Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Ning Sun, Guoqing Zhang and Jialin Zhang

    Citation: BMC Cancer 2018 18:1179

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  27. Content type: Research article

    It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterize...

    Authors: Gloria Pelizzo, Veronica Veschi, Melissa Mantelli, Stefania Croce, Vincenzo Di Benedetto, Paolo D’Angelo, Alice Maltese, Laura Catenacci, Tiziana Apuzzo, Emanuela Scavo, Antonia Moretta, Matilde Todaro, Giorgio Stassi, Maria Antonietta Avanzini and Valeria Calcaterra

    Citation: BMC Cancer 2018 18:1176

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  28. Content type: Research article

    Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-cateni...

    Authors: S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan and D. Velmurugan

    Citation: BMC Cancer 2018 18:1168

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  29. Content type: Research article

    Glycosylation plays a critical role in the aggressiveness of pancreatic cancer (PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in PC aggressiveness. However, the importanc...

    Authors: Srikanth Barkeer, Seema Chugh, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Satyanarayana Rachagani, Surinder K. Batra and Moorthy P. Ponnusamy

    Citation: BMC Cancer 2018 18:1157

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  30. Content type: Research article

    This study aimed to explore hyper-O-linked N-acetylglucosaminylation (O-GlcNAcylation) with an elevation of the expression of O-linked-β-N-acetylglucosamine transferase (OGT) in human bladder cancer.

    Authors: Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai and Xudong Yao

    Citation: BMC Cancer 2018 18:1141

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  31. Content type: Research article

    The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed i...

    Authors: Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li and Baohua Li

    Citation: BMC Cancer 2018 18:1128

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  32. Content type: Research article

    Karyopherin β1 (Kpnβ1) is the main nuclear import protein involved in the transport of cargoes from the cytoplasm into the cell nucleus. Previous research has found Kpnβ1 to be significantly overexpressed in c...

    Authors: Sarah Carden, Pauline van der Watt, Alicia Chi, Aderonke Ajayi-Smith, Katie Hadley and Virna D. Leaner

    Citation: BMC Cancer 2018 18:1123

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  33. Content type: Research article

    Various efforts to understand the relationship between biological information and disease have been done using many different types of highthroughput data such as genomics and metabolomics. However, informatio...

    Authors: Jaesik Jeong, Kwangok Seo and Eung-Sam Kim

    Citation: BMC Cancer 2018 18:1109

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  34. Content type: Research article

    Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most i...

    Authors: Liyong Zhang, Zhihong Li, Yehai Liu, Shuping Xu, Manuj Tandon, Brittany Appelboom, Courtney R. LaValle, Simion I. Chiosea, Lin Wang, Malabika Sen, Vivian W. Y. Lui, Jennifer R. Grandis and Q. Jane Wang

    Citation: BMC Cancer 2018 18:1107

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  35. Content type: Research article

    RBM3 expression has been suggested as prognostic marker in several cancer types. The purpose of this study was to assess the prevalence and clinical significance of altered RBM3 expression in esophageal cancer.

    Authors: Katharina Grupp, Bianca Hofmann, Asad Kutup, Kai Bachmann, Dean Bogoevski, Nathaniel Melling, Faik Guntac Uzunoglu, Alexander Tarek El Gammal, Christina Koop, Ronald Simon, Stefan Steurer, Till Krech, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Jakob Izbicki…

    Citation: BMC Cancer 2018 18:1106

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  36. Content type: Research article

    To investigate the influence of fibroblast activation protein alpha (FAP) derived from cancer-associated fibroblasts (CAFs), as well as potential mechanism of epithelial mesenchymal transition (EMT), on gastri...

    Authors: Jiuyang Liu, Chaoqun Huang, Chunwei Peng, Fei Xu, Yan Li, Yonemura Yutaka, Bin Xiong and Xiaojun Yang

    Citation: BMC Cancer 2018 18:1099

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  37. Content type: Research article

    Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes. Although abnormalities in cytokine signaling are common in MPN, the pathophysiology of atypical MPN stil...

    Authors: Pierre-Yves Dumas, Olivier Mansier, Valerie Prouzet-Mauleon, Junji Koya, Arnaud Villacreces, Philippe Brunet de la Grange, Damien Luque Paz, Audrey Bidet, Jean-Max Pasquet, Vincent Praloran, Franck Salin, Mineo Kurokawa, François-Xavier Mahon, Bruno Cardinaud and Eric Lippert

    Citation: BMC Cancer 2018 18:1098

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  38. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...

    Authors: Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi and Xin Chen

    Citation: BMC Cancer 2018 18:1093

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  39. Content type: Research article

    Colorectal cancer (CRC) is the most common type of gastrointestinal cancer. CRC gene therapy mediated by adenovirus holds great promise for the treatment of malignancies. However, intravenous delivery of adeno...

    Authors: Fang-Rui Liu, Shuang Bai, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Hong Fang, Jing Cui and Ju-Lun Yang

    Citation: BMC Cancer 2018 18:1087

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  40. Content type: Research article

    microRNAs (miRNAs) stably exist in circulating blood and are encapsulated in extracellular vesicles such as exosomes. The aims of this study were to identify which exosomal miRNAs are highly produced from epit...

    Authors: Akihiko Yoshimura, Kenjiro Sawada, Koji Nakamura, Yasuto Kinose, Erika Nakatsuka, Masaki Kobayashi, Mayuko Miyamoto, Kyoso Ishida, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi and Tadashi Kimura

    Citation: BMC Cancer 2018 18:1065

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  41. Content type: Review

    For decades, retinoids and their synthetic derivatives have been well established anticancer treatments due to their ability to regulate cell growth and induce cell differentiation and apoptosis. Many studies ...

    Authors: Viera Dobrotkova, Petr Chlapek, Pavel Mazanek, Jaroslav Sterba and Renata Veselska

    Citation: BMC Cancer 2018 18:1059

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  42. Content type: Research article

    Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. Nonetheless, the prognostic relevance of HER3...

    Authors: Satu Luhtala, Synnöve Staff, Anne Kallioniemi, Minna Tanner and Jorma Isola

    Citation: BMC Cancer 2018 18:1045

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  43. Content type: Research article

    New approaches for the prevention of colon cancer perseveres an essential necessity. Though, resistance to existing chemo-preventive drugs is moderately predominant in colon carcinogenesis. Taxifolin (dihydroq...

    Authors: Suhail Razak, Tayyaba Afsar, Asad Ullah, Ali Almajwal, Musaed Alkholief, Aws Alshamsan and Sarwat Jahan

    Citation: BMC Cancer 2018 18:1043

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  44. Content type: Research article

    It was demonstrated that long non-coding RNAs occupied an important position in tumor pathogenesis and progression. We have previously found that the metastasis-associated lung adenocarcinoma transcript 1 (MAL...

    Authors: Meng Zhuo, Cuncun Yuan, Ting Han, Jiujie Cui, Feng Jiao and Liwei Wang

    Citation: BMC Cancer 2018 18:1032

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  45. Content type: Research article

    Remodeling of Ca2+ signaling is an important step in cancer progression, and altered expression of members of the Ca2+ signaling toolkit including the plasma membrane Ca2+ ATPases (PMCA proteins encoded by ATP2B ...

    Authors: Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi and Rita Padányi

    Citation: BMC Cancer 2018 18:1029

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  46. Content type: Research article

    The dismal prognosis of patients with glioblastoma (GBM) is attributed to a rare subset of cancer stem cells that display characteristics of tumor initiation, growth, and resistance to aggressive treatment inv...

    Authors: Brian Tung, Ding Ma, Shuyan Wang, Olutobi Oyinlade, John Laterra, Mingyao Ying, Sheng-Qing Lv, Shuang Wei and Shuli Xia

    Citation: BMC Cancer 2018 18:1025

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  48. Content type: Research article

    NDRG2 is identified as a tumor suppressor gene in many tumors, and functions in cell proliferation, differentiation and apoptosis. Recent data indicate that NDRG2 expression is up-regulated by TP53. Moreover, pro...

    Authors: Yu-Qiong Yang, Tian Tian, Hua-Yuan Zhu, Jin-Hua Liang, Wei Wu, Jia-Zhu Wu, Yi Xia, Li Wang, Lei Fan, Jian-Yong Li and Wei Xu

    Citation: BMC Cancer 2018 18:1009

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  49. Content type: Research article

    Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with auto...

    Authors: Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang and Yingyu Nan

    Citation: BMC Cancer 2018 18:984

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  50. Content type: Research article

    In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytop...

    Authors: Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck

    Citation: BMC Cancer 2018 18:981

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