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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Macrophages in the tumor microenvironment play a critical role in tumorigenesis and anti-cancer drug resistance. Burkitt’s lymphoma (BL) is a B-cell non-Hodgkin’s lymphoma with dense macrophage infiltration. H...

    Authors: Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu and Yin Tong

    Citation: BMC Cancer 2018 18:467

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  2. Content type: Research article

    The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistan...

    Authors: Catja Freiburghaus, Venera Kuci Emruli, Angelica Johansson, Christian Winther Eskelund, Kirsten Grønbæk, Roger Olsson, Fredrik Ek, Mats Jerkeman and Sara Ek

    Citation: BMC Cancer 2018 18:466

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  3. Content type: Research article

    Programmed death-ligand 1 (PD-L1) is an immunosuppressor that plays an important role in cancer treatments. Although majority of the studies demonstrated that PD-L1 expression was regulated by cellular intrins...

    Authors: Chenlu Zhang, Zhi Li, Ling Xu, Xiaofang Che, Ti Wen, Yibo Fan, Ce Li, Shuo Wang, Yu Cheng, Xiaoxun Wang, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2018 18:462

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  4. Content type: Research article

    Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not si...

    Authors: Shu-ta Wu, Anthony J. Fowler, Corey B. Garmon, Adam B. Fessler, Joshua D. Ogle, Kajal R. Grover, Bailey C. Allen, Chandra D. Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A. Ogle and Pinku Mukherjee

    Citation: BMC Cancer 2018 18:457

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  5. Content type: Research article

    AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothe...

    Authors: Veronika Seebacher, Stephan Polterauer, Alexander Reinthaller, Heinz Koelbl, Regina Achleitner, Astrid Berger and Nicole Concin

    Citation: BMC Cancer 2018 18:447

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  6. Content type: Research article

    Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of th...

    Authors: Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng and You-Guang Lu

    Citation: BMC Cancer 2018 18:436

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  7. Content type: Research article

    Multiple trials have attempted to demonstrate the effective induction of cell death in TRAIL-resistant cancer cells, including using a combined treatment of recombinant TRAIL and various proteasome inhibitors....

    Authors: Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon, Jeong Hwan Chang, Yoonkyung Park, Tae-Hyoung Kim, Amanda R. Howland, Cheryl A. Armstrong, Peter I. Song and Ae Ran Moon

    Citation: BMC Cancer 2018 18:432

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  8. Content type: Research article

    Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes ...

    Authors: Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li and Jie Chen

    Citation: BMC Cancer 2018 18:426

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  9. Content type: Research article

    Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallma...

    Authors: Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones and Steven S. Foster

    Citation: BMC Cancer 2018 18:423

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  10. Content type: Research article

    Many novel diagnostic biomarkers have been developed for gastric cancer (GC) recently. We chose two methods with high diagnostic value, the detection of serum microRNAs and metabolomics based on gas chromatogr...

    Authors: Hai-Ning Liu, Hao Wu, Yu-Jen Tseng, Yan-Jie Chen, Dan-Ying Zhang, Lin Zhu, Ling Dong, Xi-Zhong Shen and Tao-Tao Liu

    Citation: BMC Cancer 2018 18:415

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  11. Content type: Research article

    The expression of DNA fragmentation factor 45 (DFF45) and B-cell lymphoma 2 (BCL2) in glands of the normal human endometrium is related to phases of the menstrual cycle and decreases after menopause, whereas t...

    Authors: Tomasz Banas, Kazimierz Pitynski, Krzysztof Okon and Aleksandra Winiarska

    Citation: BMC Cancer 2018 18:418

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  12. Content type: Research article

    Dysregulation of microRNA (miRNA) expression is associated with hallmarks of aggressive tumor phenotypes, e.g., enhanced cell growth, proliferation, invasion, and anchorage independent growth in prostate cance...

    Authors: Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal and LaCreis R. Kidd

    Citation: BMC Cancer 2018 18:421

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  13. Content type: Research article

    Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp famil...

    Authors: Xia Kong, Pin Xu, Wei-Jie Cai, Huai-Gao Wang, Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen and Cai-Guo Ye

    Citation: BMC Cancer 2018 18:419

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  14. Content type: Research article

    Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the compone...

    Authors: Sang-Nee Tan and Sai-Peng Sim

    Citation: BMC Cancer 2018 18:409

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  15. Content type: Research article

    Melanoma is notoriously resistant to all current modalities of cancer therapies including chemotherapy. In recent years, microRNAs (miRNAs) have emerged as molecular regulators in the development and progressi...

    Authors: Yuxia Li, Jie Zhang, Yajing Liu, Bingyue Zhang, Fubo Zhong, Shubin Wang and Zhengyu Fang

    Citation: BMC Cancer 2018 18:404

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  16. Content type: Research article

    Thirty to 40 % of non-small cell lung cancer (NSCLC) patients developed higher hypertriglyceridemia in the process of treatment with bexarotene. And bioinformatics studies discovered that the expression of slc...

    Authors: Xinghao Ai, Feng Mao, Shengping Shen, Yang Shentu, Jiejun Wang and Shun Lu

    Citation: BMC Cancer 2018 18:407

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  17. Content type: Research article

    Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in ...

    Authors: Frank K. Leusink, Eleftherios Koudounarakis, Michael H. Frank, Ronald Koole, Paul J. van Diest and Stefan M. Willems

    Citation: BMC Cancer 2018 18:385

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  18. Content type: Research article

    Macrophage heterogeneity is the main feature of the tumour microenvironment. Breast cancer is one of the most life-threatening cancers. However, macrophage polarization patterns in different tumour stages and ...

    Authors: Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen and Ming-Feng Hou

    Citation: BMC Cancer 2018 18:366

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  19. Content type: Research article

    Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understandi...

    Authors: Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal and Radhika Srinivasan

    Citation: BMC Cancer 2018 18:357

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  20. Content type: Research article

    Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of ca...

    Authors: Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson and Michael Ladomery

    Citation: BMC Cancer 2018 18:355

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  21. Content type: Research article

    Cancer cachexia is a cancer-induced metabolic disorder and a major cause of cancer-induced death. The constituents of cancer cachexia include an increase in energy expenditure, hepatic gluconeogenesis, fat lip...

    Authors: Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui and Wencong Tian

    Citation: BMC Cancer 2018 18:360

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  22. Content type: Research article

    The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, c...

    Authors: Chengsheng Wu, Nidhi Gupta, Yung-Hsing Huang, Hai-Feng Zhang, Abdulraheem Alshareef, Alexandra Chow and Raymond Lai

    Citation: BMC Cancer 2018 18:361

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  23. Content type: Research article

    Volatile organic compounds (VOCs) emitted from exhaled breath from human bodies have been proven to be a useful source of information for early lung cancer diagnosis. To date, there are still arguable informat...

    Authors: Reena Thriumani, Ammar Zakaria, Yumi Zuhanis Has-Yun Hashim, Amanina Iymia Jeffree, Khaled Mohamed Helmy, Latifah Munirah Kamarudin, Mohammad Iqbal Omar, Ali Yeon Md Shakaff, Abdul Hamid Adom and Krishna C. Persaud

    Citation: BMC Cancer 2018 18:362

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  24. Content type: Research article

    Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty acid) to form 2-series of prostaglandins known to be...

    Authors: Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins and Steven Y. Qian

    Citation: BMC Cancer 2018 18:330

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  25. Content type: Research article

    Reg IV is a member of the regenerating gene family and has been demonstrated to be overexpressed in gastric cancer. However, the functional mechanism of Reg IV in gastric cancer is still unclear.

    Authors: Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian and Yang Xu

    Citation: BMC Cancer 2018 18:344

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  26. Content type: Research article

    Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic cancer organoids has not yet been broadly impleme...

    Authors: Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan and Michael A. James

    Citation: BMC Cancer 2018 18:335

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  27. Content type: Research article

    Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer. Karyopherin alpha 7 (KPNA7), the ...

    Authors: Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen and Anne Kallioniemi

    Citation: BMC Cancer 2018 18:325

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  28. Content type: Research article

    We have previously demonstrated the anticancer effect of anthocyanins. In this study, we explored the biological activities of delphinidin, the most common of the anthocyanidin monomers, that were related to a...

    Authors: Jingyao Chen, Yanfeng Zhu, Weiwei Zhang, Xiaoli Peng, Jie Zhou, Fei Li, Bin Han, Xin Liu, Yu Ou and Xiaoping Yu

    Citation: BMC Cancer 2018 18:342

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  29. Content type: Research article

    Androgen receptor (AR) is widely expressed in breast cancer (BC) but its role in estrogen receptor (ER)-positive tumors is still controversial. The AR/ER ratio has been reported to impact prognosis and respons...

    Authors: Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori and Sara Bravaccini

    Citation: BMC Cancer 2018 18:348

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  30. Content type: Debate

    Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome....

    Authors: Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi and Claudio Bassi

    Citation: BMC Cancer 2018 18:293

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  31. Content type: Research article

    Smurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein substrates. The multi-functional scaffold protein Connector enhancer of kinase suppressor of ras 2 ...

    Authors: Diana David, Arun Surendran, Jissa V. Thulaseedharan and Asha S. Nair

    Citation: BMC Cancer 2018 18:284

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  32. Content type: Research article

    Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi re...

    Authors: Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li and Xuejie Fei

    Citation: BMC Cancer 2018 18:255

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  33. Content type: Research article

    High-grade chondrosarcoma, which has a high incidence of local recurrence and pulmonary metastasis despite surgical resection, is associated with poor prognosis. Therefore, new and effective adjuvant therapies...

    Authors: Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi and Masashi Neo

    Citation: BMC Cancer 2018 18:263

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  34. Content type: Research article

    Angiogenesis is a process of formation of new blood vessels and is an important criteria demonstrated by cancer cells. Over a period of time, these cancer cells infect the other parts of the healthy body by a ...

    Authors: Shailima Rampogu, Ayoung Baek, Amir Zeb and Keun Woo Lee

    Citation: BMC Cancer 2018 18:264

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  35. Content type: Research article

    TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low s...

    Authors: Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang and Qun Wang

    Citation: BMC Cancer 2018 18:260

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  36. Content type: Research article

    In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers, drives AKT activity. Constitutive activation of the PI3K...

    Authors: Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès and Vincent Picco

    Citation: BMC Cancer 2018 18:249

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  37. Content type: Research article

    Paclitaxel (PTX) is a potent anti-cancer drug commonly used for the treatment of advanced breast cancer (BCA) and melanoma. Toll-like receptor 4 (TLR4) promotes the production of pro-inflammatory cytokines ass...

    Authors: Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee and Chanitra Thuwajit

    Citation: BMC Cancer 2018 18:231

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  38. Content type: Research article

    It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast st...

    Authors: Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström and Håkan Olsson

    Citation: BMC Cancer 2018 18:230

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  39. Content type: Research article

    Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion proteins, such as E-cadherin, and desmosomal proteins a...

    Authors: Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun and Valérie Lobjois

    Citation: BMC Cancer 2018 18:221

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  40. Content type: Research article

    MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosar...

    Authors: Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters and Janet M. Shipley

    Citation: BMC Cancer 2018 18:217

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  41. Content type: Research article

    Accumulating evidence suggest that autophagy plays a pivotal role in various anticancer therapies, including photodynamic therapy (PDT), acting as a pro-death or pro-survival mechanism in a context-dependent m...

    Authors: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab and Malgorzata Firczuk

    Citation: BMC Cancer 2018 18:210

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  42. Content type: Research article

    Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-a...

    Authors: Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira and Fabio Dall’Olio

    Citation: BMC Cancer 2018 18:198

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  43. Content type: Research article

    Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in sever...

    Authors: Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand and Uwe Knippschild

    Citation: BMC Cancer 2018 18:140

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  44. Content type: Debate

    The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential f...

    Authors: Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger and Sabine Grösch

    Citation: BMC Cancer 2018 18:153

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