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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts.

    Authors: Hari Raghu, Prasanna Kumar Sodadasu, Rama Rao Malla, Christopher S Gondi, Norman Estes and Jasti S Rao

    Citation: BMC Cancer 2010 10:647

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  2. Content type: Research article

    Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination,...

    Authors: Dusan Djokovic, Alexandre Trindade, Joana Gigante, Marina Badenes, Lilliana Silva, Ren Liu, Xiuqing Li, Ming Gong, Valery Krasnoperov, Parkash S Gill and Antonio Duarte

    Citation: BMC Cancer 2010 10:641

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  3. Content type: Research article

    Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and constitute a central component in the therapy of lymphoid malignancies, most notably childhood acute lymphoblastic leukemia (AL...

    Authors: Michela Carlet, Kristina Janjetovic, Johannes Rainer, Stefan Schmidt, Renate Panzer-Grümayer, Georg Mann, Martina Prelog, Bernhard Meister, Christian Ploner and Reinhard Kofler

    Citation: BMC Cancer 2010 10:638

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  4. Content type: Research article

    Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy resistance and poor prognosis. However, little is ...

    Authors: Jacqueline Kessler, Antje Hahnel, Henri Wichmann, Swetlana Rot, Matthias Kappler, Matthias Bache and Dirk Vordermark

    Citation: BMC Cancer 2010 10:605

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  5. Content type: Research article

    Very low density lipoprotein receptor (VLDLR) has been considered as a multiple function receptor due to binding numerous ligands, causing endocytosis and regulating cellular signaling. Our group previously re...

    Authors: Lei He, Yanjun Lu, Peng Wang, Jun Zhang, Chuanchang Yin and Shen Qu

    Citation: BMC Cancer 2010 10:601

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  6. Content type: Research article

    Lung cancer causes the highest rate of cancer-related deaths both in men and women. As many current treatment modalities are inadequate in increasing patient survival, new therapeutic strategies are required. ...

    Authors: Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith and Salih Sanlioglu

    Citation: BMC Cancer 2010 10:584

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  7. Content type: Research article

    Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng and Zhao-You Tang

    Citation: BMC Cancer 2010 10:580

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  8. Content type: Research article

    The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα.

    Authors: Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi and Yoshinori Otsuki

    Citation: BMC Cancer 2010 10:566

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  9. Content type: Research article

    Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphobl...

    Authors: Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund and Christian Junghanss

    Citation: BMC Cancer 2010 10:560

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  10. Content type: Research article

    Combining MEK inhibitors with other signalling pathway inhibitors or conventional cytotoxic drugs represents a promising new strategy against cancer. RDEA119/BAY 869766 is a highly potent and selective MEK1/2 ...

    Authors: Qing Chang, Mark S Chapman, Jeffrey N Miner and David W Hedley

    Citation: BMC Cancer 2010 10:515

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  11. Content type: Research article

    Tumour growth and metastatic infiltration are favoured by several components of the tumour microenvironment. Bone marrow-derived multipotent mesenchymal stromal cells (MSC) are known to contribute to the tumou...

    Authors: Pascal-David Johann, Martin Vaegler, Friederike Gieseke, Philippa Mang, Sorin Armeanu-Ebinger, Torsten Kluba, Rupert Handgretinger and Ingo Müller

    Citation: BMC Cancer 2010 10:501

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  12. Content type: Research article

    An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. In endometrial adenocarcinoma F-prostanoid (FP) receptor expression is ...

    Authors: Margaret C Keightley, Kurt J Sales and Henry N Jabbour

    Citation: BMC Cancer 2010 10:488

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  13. Content type: Research article

    17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Lukas H Margaritis and Gerassimos E Voutsinas

    Citation: BMC Cancer 2010 10:481

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  14. Content type: Research article

    Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation...

    Authors: Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley and Dean A Fennell

    Citation: BMC Cancer 2010 10:380

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  15. Content type: Research article

    Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phe...

    Authors: Helen J Knowles, Karl-Ludwig Schaefer, Uta Dirksen and Nicholas A Athanasou

    Citation: BMC Cancer 2010 10:372

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