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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malign...

    Authors: Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy and Andrew M Chan

    Citation: BMC Cancer 2011 11:490

    Content type: Research article

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  2. Targeting the ubiquitin-proteasome pathway is a promising approach for anticancer strategies. Recently, we found Bik accumulation in cancer cell lines after they were treated with bortezomib. However, recent e...

    Authors: Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He and Hongbo Zhu

    Citation: BMC Cancer 2011 11:485

    Content type: Research article

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  3. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF s...

    Authors: Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin and Vincent J Gnanapragasam

    Citation: BMC Cancer 2011 11:484

    Content type: Research article

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  4. Targeted therapies are becoming an essential part of breast cancer treatment and agents targeting the type I insulin-like growth factor receptor (IGF-IR) are currently being investigated in clinical trials. On...

    Authors: Craig I Campbell and Roger A Moorehead

    Citation: BMC Cancer 2011 11:480

    Content type: Research article

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  5. Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicab...

    Authors: Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar and Simon P Langdon

    Citation: BMC Cancer 2011 11:476

    Content type: Research article

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  6. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional com...

    Authors: Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio and Angélica Figueroa

    Citation: BMC Cancer 2011 11:474

    Content type: Research article

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  7. The evolutionary dynamics between interacting heterogeneous cell types are fundamental properties of neoplastic progression but can be difficult to measure and quantify. Cancers are heterogeneous mixtures of m...

    Authors: Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner and Carlo C Maley

    Citation: BMC Cancer 2011 11:461

    Content type: Research article

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  8. HDGF is a growth factor which is overexpressed in a wide range of tumors. Importantly, expression levels were identified as a prognostic marker in some types of cancer such as melanoma.

    Authors: Angela Sedlmaier, Nicolas Wernert, Rainer Gallitzendörfer, Mekky M Abouzied, Volkmar Gieselmann and Sebastian Franken

    Citation: BMC Cancer 2011 11:457

    Content type: Research article

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  9. Nck1 and Nck2 adaptor proteins are involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response. Overexpression of Nck1 in fibroblasts has been shown to be o...

    Authors: Mélissa Labelle-Côté, Julie Dusseault, Salma Ismaïl, Aude Picard-Cloutier, Peter M Siegel and Louise Larose

    Citation: BMC Cancer 2011 11:443

    Content type: Research article

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  10. Hepatocyte Nuclear Factor 1α (HNF1α) is an atypical homeodomain-containing transcription factor that transactivates liver-specific genes including albumin, α-1-antitrypsin and α- and β-fibrinogen. Biallelic in...

    Authors: Laura Pelletier, Sandra Rebouissou, Danijela Vignjevic, Paulette Bioulac-Sage and Jessica Zucman-Rossi

    Citation: BMC Cancer 2011 11:427

    Content type: Research article

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  11. Our previous studies have identified that miR-125b was overexpressed in type II endometrial carcinoma (EC) cells compared with type I using microRNAs microarray. Although recent studies have shown the importan...

    Authors: Feizhou Jiang, Te Liu, Yinyan He, Qin Yan, Xiaoyue Chen, Hui Wang and Xiaoping Wan

    Citation: BMC Cancer 2011 11:425

    Content type: Research article

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  12. Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear. We have examined signalling pathwa...

    Authors: Kristin M Müller, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Mona Dawood, Olav Dajani, Thoralf Christoffersen and Dagny L Sandnes

    Citation: BMC Cancer 2011 11:421

    Content type: Research article

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  13. Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown...

    Authors: Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn and Göran Landberg

    Citation: BMC Cancer 2011 11:417

    Content type: Research article

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  14. Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra ce...

    Authors: Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli and Malka Cohen-Armon

    Citation: BMC Cancer 2011 11:412

    Content type: Research article

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  15. The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information o...

    Authors: Enke Baldini, Yannick Arlot-Bonnemains, Salvatore Sorrenti, Caterina Mian, Maria R Pelizzo, Enrico De Antoni, Silvio Palermo, Stefania Morrone, Susi Barollo, Angela Nesca, Costanzo G Moretti, Massimino D'Armiento and Salvatore Ulisse

    Citation: BMC Cancer 2011 11:411

    Content type: Research article

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  16. 14-3-3 proteins are a family of highly conserved proteins that are involved in a wide range of cellular processes. Recent evidence indicates that some of these proteins have oncogenic activity and that they ma...

    Authors: Vijayababu M Radhakrishnan, Charles W Putnam, Wenqing Qi and Jesse D Martinez

    Citation: BMC Cancer 2011 11:378

    Content type: Research article

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  17. Epidemiological evidence suggests that moderately elevated levels of circulating insulin-like growth factor-I (IGF-I) are associated with increased risk of breast cancer in women. How circulating IGF-I may pro...

    Authors: Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu and Adrian V Lee

    Citation: BMC Cancer 2011 11:377

    Content type: Research article

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  18. Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous stu...

    Authors: Sudhakar Chintharlapalli, Sabitha Papineni, Ping Lei, Satya Pathi and Stephen Safe

    Citation: BMC Cancer 2011 11:371

    Content type: Research article

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  19. Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth of various malignancies. A common inflammatory condition in humans is autoimmune arth...

    Authors: Lopamudra Das Roy, Sriparna Ghosh, Latha B Pathangey, Teresa L Tinder, Helen E Gruber and Pinku Mukherjee

    Citation: BMC Cancer 2011 11:365

    Content type: Research article

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  20. The fusion protein VEGF121/rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects. We have previously shown that VEGF12...

    Authors: Khalid A Mohamedali, Sophia Ran, Candelaria Gomez-Manzano, Latha Ramdas, Jing Xu, Sehoon Kim, Lawrence H Cheung, Walter N Hittelman, Wei Zhang, Johannes Waltenberger, Philip E Thorpe and Michael G Rosenblum

    Citation: BMC Cancer 2011 11:358

    Content type: Research article

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  21. Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a rol...

    Authors: Benedicte Stavik, Grethe Skretting, Hans-Christian Aasheim, Mari Tinholt, Lillian Zernichow, Marit Sletten, Per Morten Sandset and Nina Iversen

    Citation: BMC Cancer 2011 11:357

    Content type: Research article

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  22. Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to hypoxia. It is essential for angiogenesis and is associated with tumor progression and overexpression of HIF-1α has b...

    Authors: Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar and Kalpana S Joshi

    Citation: BMC Cancer 2011 11:338

    Content type: Research article

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  23. A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and meta...

    Authors: Ju-Hee Kang, Ki-Hoon Song, Kyung-Chae Jeong, Sunshin Kim, Changsun Choi, Chang Hoon Lee and Seung Hyun Oh

    Citation: BMC Cancer 2011 11:334

    Content type: Research article

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  24. 5-allyl-7-gen-difluoromethoxychrysin (AFMC) is a novel synthetic analogue of chrysin that has been reported to inhibit proliferation in various cancer cell lines. Tumor necrosis factor-related apoptosis-induci...

    Authors: Zhao-Hui Xie, Mei-Fang Quan, Fei Liu, Jian-Guo Cao and Jian-Song Zhang

    Citation: BMC Cancer 2011 11:322

    Content type: Research article

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  25. Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose res...

    Authors: Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach and Johannes Rieger

    Citation: BMC Cancer 2011 11:315

    Content type: Research article

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  26. E7080 is an orally active multi-targeted kinase inhibitor whose targets include vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor...

    Authors: Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod and Valerie G Brunton

    Citation: BMC Cancer 2011 11:309

    Content type: Research article

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  27. Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies, including brain tumors. In human brain cancer, especially...

    Authors: Rita Ferla, Maria Bonomi, Laszlo Otvos Jr and Eva Surmacz

    Citation: BMC Cancer 2011 11:303

    Content type: Research article

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  28. Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target ...

    Authors: Virginie Follin-Arbelet, Peter O Hofgaard, Harald Hauglin, Soheil Naderi, Anders Sundan, Rune Blomhoff, Bjarne Bogen and Heidi K Blomhoff

    Citation: BMC Cancer 2011 11:301

    Content type: Research article

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  29. Emmprin, a glycoprotein containing two Ig domains, is enriched on tumor cell surfaces and stimulates matrix metalloproteinase (MMP) production by adjacent stromal cells. Its first Ig domain (ECI) contains the ...

    Authors: Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki and Kazuki Nabeshima

    Citation: BMC Cancer 2011 11:300

    Content type: Research article

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  30. Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effe...

    Authors: Fabiana A Serrano, Alisson L Matsuo, Priscila T Monteforte, Alexandre Bechara, Soraya S Smaili, Débora P Santana, Tiago Rodrigues, Felipe V Pereira, Luis S Silva, Joel Machado Jr, Edson L Santos, João B Pesquero, Rafael M Martins, Luiz R Travassos, Antonio CF Caires and Elaine G Rodrigues

    Citation: BMC Cancer 2011 11:296

    Content type: Research article

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  31. Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors ...

    Authors: Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric R Paquet, Roscoe Klinck, François A Auger and Jacques Huot

    Citation: BMC Cancer 2011 11:285

    Content type: Research article

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  32. Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin level...

    Authors: Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka and Hisataka Moriwaki

    Citation: BMC Cancer 2011 11:281

    Content type: Research article

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  33. Recently we reported that activation of Epac1, an exchange protein activated by cAMP, increases melanoma cell migration via Ca 2+ release from the endoplasmic reticulum (ER). G-protein βγ subunits (Gβγ) are known...

    Authors: Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos and Kousaku Iwatsubo

    Citation: BMC Cancer 2011 11:256

    Content type: Research article

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  34. The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The r...

    Authors: Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao and Wenchao Liu

    Citation: BMC Cancer 2011 11:251

    Content type: Research article

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  35. The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regu...

    Authors: Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo and Olufunmilayo I Olopade

    Citation: BMC Cancer 2011 11:246

    Content type: Research article

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  36. Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively pr...

    Authors: Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman and Jonathan D Cheng

    Citation: BMC Cancer 2011 11:245

    Content type: Research article

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  37. Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis. ...

    Authors: Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger and Martin Hagedorn

    Citation: BMC Cancer 2011 11:241

    Content type: Research article

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  38. Tumor cells adapt to endoplasmic reticulum (ER) stress through a set of conserved intracellular pathways, as part of a process termed the unfolded protein response (UPR). The expression of UPR genes/proteins c...

    Authors: Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler and Maurizio Zanetti

    Citation: BMC Cancer 2011 11:229

    Content type: Research article

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  39. LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non...

    Authors: Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu and Yongming Luo

    Citation: BMC Cancer 2011 11:227

    Content type: Research article

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  40. Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein. Genistein may inhibit cancer progression by inducing apoptosis or i...

    Authors: Wentao Qi, Christopher R Weber, Kaarin Wasland and Suzana D Savkovic

    Citation: BMC Cancer 2011 11:219

    Content type: Research article

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  41. Heparin affin regulatory peptide (HARP), also called pleiotrophin, is a heparin-binding, secreted factor that is overexpressed in several tumours and associated to tumour growth, angiogenesis and metastasis. T...

    Authors: Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty and Jean Delbé

    Citation: BMC Cancer 2011 11:212

    Content type: Research article

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  42. Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis...

    Authors: Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev and Ola Myklebost

    Citation: BMC Cancer 2011 11:211

    Content type: Research article

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  43. Mifepristone (MF) has been largely used in reproductive medicine due to its capacity to modulate the progesterone receptor (PR). The study of MF has been expanded to the field of oncology; yet it remains uncle...

    Authors: Chelsea R Tieszen, Alicia A Goyeneche, BreeAnn N Brandhagen, Casey T Ortbahn and Carlos M Telleria

    Citation: BMC Cancer 2011 11:207

    Content type: Research article

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  44. Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within the 3q26 region. Functional study has demonstrated the oncog...

    Authors: Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael SY Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu and Xin-Yuan Guan

    Citation: BMC Cancer 2011 11:199

    Content type: Research article

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