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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Medulloblastoma is a highly malignant pediatric brain tumor that requires surgery, whole brain and spine irradiation, and intense chemotherapy for treatment. A more sophisticated understanding of the pathophys...

    Authors: Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard and Harald Sontheimer

    Citation: BMC Cancer 2011 11:136

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  2. Content type: Research article

    The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine ...

    Authors: Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman and Adit Ben-Baruch

    Citation: BMC Cancer 2011 11:130

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  3. Content type: Research article

    We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced exp...

    Authors: Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell and Cheryl A London

    Citation: BMC Cancer 2011 11:125

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  4. Content type: Research article

    Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C™), and other...

    Authors: Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally and Donald T Yapp

    Citation: BMC Cancer 2011 11:124

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  5. Content type: Research article

    Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mecha...

    Authors: Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin and Øystein Rekdal

    Citation: BMC Cancer 2011 11:116

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  6. Content type: Research article

    Gastric cancer is the second most common cause of global cancer-related mortality. Although dedifferentiation predicts poor prognosis in gastric cancer, the molecular mechanism underlying dedifferentiation, wh...

    Authors: Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu and Qinlong Gu

    Citation: BMC Cancer 2011 11:109

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  7. Content type: Research article

    It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs. The current study was designed to investigate whether resv...

    Authors: Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan and Hua-Qin Wang

    Citation: BMC Cancer 2011 11:99

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  8. Content type: Research article

    The purpose of this study was to assess the expression levels for TβRI, TβRII, and TβRIII in epithelial layers of oral premalignant lesions (oral leukoplakia, OLK) and oral squamous cell carcinoma (OSCC), as w...

    Authors: Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao and Hongmei Zhou

    Citation: BMC Cancer 2011 11:88

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  9. Content type: Research article

    Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT.

    Authors: Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa and Veli-Matti Kosma

    Citation: BMC Cancer 2011 11:73

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  10. Content type: Research article

    Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular p...

    Authors: Yi Zhang, Rachel M Gonzalez and Richard C Zangar

    Citation: BMC Cancer 2011 11:69

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  11. Content type: Research article

    Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the con...

    Authors: Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen and Jens Overgaard

    Citation: BMC Cancer 2011 11:63

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  12. Content type: Research article

    Transforming growth factor (TGF)-β plays a dual role during mammary gland development and tumorigenesis and has been shown to stimulate epithelial-mesenchymal transition (EMT) as well as cellular migration. Th...

    Authors: Kelly J Gauger, Kerry L Chenausky, Molly E Murray and Sallie S Schneider

    Citation: BMC Cancer 2011 11:59

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  13. Content type: Research article

    Histone modifications in tumorigenesis are increasingly recognized as important epigenetic factors leading to cancer. Increased phosphorylation levels of histone H3 as a result of aurora B and pMSK1 overexpres...

    Authors: Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu and Jan-Gowth Chang

    Citation: BMC Cancer 2011 11:58

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  14. Content type: Research article

    This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC.

    Authors: Yang Yuan, Zhi-Yong Zeng, Xiao-Hong Liu, De-Jun Gong, Jing Tao, He-Zhong Cheng and Sheng-Dong Huang

    Citation: BMC Cancer 2011 11:57

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  15. Content type: Research article

    Mammary carcinomas have been associated with a high-fat diet, and the rate of breast cancer in overweight post-menopausal women is up to 50% higher than in their normal-weight counterparts. Epidemiological stu...

    Authors: Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel Gerstein, Theodoros Tsakiridis and Gurmit Singh

    Citation: BMC Cancer 2011 11:56

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  16. Content type: Research article

    Adeno-associated virus-2 (AAV-2)-mediated gene therapy is quite suitable for local or regional application in head and neck cancer squamous cell carcinoma (HNSCC). However, its low transduction efficiency has ...

    Authors: Minghong Jiang, Zheng Liu, Yang Xiang, Hong Ma, Shilian Liu, Yanxin Liu and Dexian Zheng

    Citation: BMC Cancer 2011 11:54

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  17. Content type: Research article

    The esophageal carcinoma related gene 4 (ECRG4) was initially identified and cloned from human normal esophageal epithelium in our laboratory (GenBank accession no.AF325503). ECRG4 has been described as a nove...

    Authors: Lin-wei Li, Yuan-yuan Li, Xiao-yan Li, Chun-peng Zhang, Yun Zhou and Shih-Hsin Lu

    Citation: BMC Cancer 2011 11:52

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  18. Content type: Research article

    NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring ...

    Authors: Gayle Bennett, Denise Sadlier, Peter P Doran, Padraic MacMathuna and David W Murray

    Citation: BMC Cancer 2011 11:50

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  19. Content type: Research article

    Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for prolifera...

    Authors: Junlin Li and Binhua P Zhou

    Citation: BMC Cancer 2011 11:49

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  20. Content type: Research article

    Retinoid receptor-induced gene-1 (RRIG1) is a novel gene that has been lost in several types of human cancers. The aim of this study was to determine whether RRIG1 plays a role in breast cancer, such as in the...

    Authors: Guihong Zhang, Abenaa Brewster, Baoxiang Guan, Zhen Fan, Powel H Brown and Xiao-Chun Xu

    Citation: BMC Cancer 2011 11:32

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  21. Content type: Research article

    Antiangiogenesis is a promising therapy for advanced hepatocellular carcinoma (HCC), but the effects are difficult to be evaluated. Pazopanib (GW786034B) is a pan-vascular endothelial growth factor receptor in...

    Authors: Xiao-Dong Zhu, Ju-Bo Zhang, Pei-Li Fan, Yu-Quan Xiong, Peng-Yuan Zhuang, Wei Zhang, Hua-Xiang Xu, Dong-Mei Gao, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang, Hong Ding and Hui-Chuan Sun

    Citation: BMC Cancer 2011 11:28

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  22. Content type: Research article

    Osteopontin (OPN) is a secreted phosphoprotein often overexpressed at high levels in the blood and primary tumors of breast cancer patients. OPN contains two integrin-binding sites and a thrombin cleavage doma...

    Authors: Michel S Beausoleil, Erika B Schulze, David Goodale, Carl O Postenka and Alison L Allan

    Citation: BMC Cancer 2011 11:25

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  23. Content type: Research article

    The JAK2V617F mutation plays a major role in the pathogenesis of myeloproliferative neoplasms and is found in the vast majority of patients suffering from polycythemia vera and in roughly every second patient suf...

    Authors: Joëlle Rubert, Zhiyan Qian, Rita Andraos, Daniel A Guthy and Thomas Radimerski

    Citation: BMC Cancer 2011 11:24

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  24. Content type: Research article

    ARHI is a Ras-related imprinted gene that inhibits cancer cell growth and motility. ARHI is downregulated in the majority of breast cancers, and loss of its expression is associated with its progression from duc...

    Authors: Chun-Fang Zou, Luoqi Jia, Hongyan Jin, Ming Yao, Naiqing Zhao, Jin Huan, Zhen Lu, Robert C Bast Jr, Youji Feng and Yinhua Yu

    Citation: BMC Cancer 2011 11:22

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  25. Content type: Research article

    Mounting evidence has indicated that ABI3 (ABI family member 3) function as a tumor suppressor gene, although the molecular mechanism by which ABI3 acts remains largely unknown.

    Authors: Flavia RM Latini, Jefferson P Hemerly, Beatriz CG Freitas, Gisele Oler, Gregory J Riggins and Janete M Cerutti

    Citation: BMC Cancer 2011 11:11

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  26. Content type: Research article

    Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effect...

    Authors: Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova and Antoni Benito

    Citation: BMC Cancer 2011 11:9

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  27. Content type: Research article

    The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an important role in cancer cell proliferation and survival. ERK1/2 proteins also are important for normal cell functions. Thus, anti-ca...

    Authors: Sarice R Boston, Rahul Deshmukh, Scott Strome, U Deva Priyakumar, Alexander D MacKerell Jr and Paul Shapiro

    Citation: BMC Cancer 2011 11:7

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  28. Content type: Research article

    Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove to be effective in treatment of glioblastoma multiforme, the most common and most aggressive primary...

    Authors: Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu and David X Liu

    Citation: BMC Cancer 2010 10:684

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  29. Content type: Research article

    Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to...

    Authors: Joseph R Cohen, Daniel Z Resnick, Pawel Niewiadomski, Hongmei Dong, Linda M Liau and James A Waschek

    Citation: BMC Cancer 2010 10:676

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  30. Content type: Research article

    Coiled-coil domain containing 115 (Ccdc115) or coiled coil protein-1 (ccp1) was previously identified as a downstream gene of Fibroblast Growth Factor 2 (FGF2) highly expressed in embryonic and adult brain. Ho...

    Authors: Francesca Pellicano, Rachel E Thomson, Gareth J Inman and Tomoko Iwata

    Citation: BMC Cancer 2010 10:657

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  31. Content type: Research article

    uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts.

    Authors: Hari Raghu, Prasanna Kumar Sodadasu, Rama Rao Malla, Christopher S Gondi, Norman Estes and Jasti S Rao

    Citation: BMC Cancer 2010 10:647

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  32. Content type: Research article

    Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination,...

    Authors: Dusan Djokovic, Alexandre Trindade, Joana Gigante, Marina Badenes, Lilliana Silva, Ren Liu, Xiuqing Li, Ming Gong, Valery Krasnoperov, Parkash S Gill and Antonio Duarte

    Citation: BMC Cancer 2010 10:641

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  33. Content type: Research article

    Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and constitute a central component in the therapy of lymphoid malignancies, most notably childhood acute lymphoblastic leukemia (AL...

    Authors: Michela Carlet, Kristina Janjetovic, Johannes Rainer, Stefan Schmidt, Renate Panzer-Grümayer, Georg Mann, Martina Prelog, Bernhard Meister, Christian Ploner and Reinhard Kofler

    Citation: BMC Cancer 2010 10:638

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  34. Content type: Research article

    Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy resistance and poor prognosis. However, little is ...

    Authors: Jacqueline Kessler, Antje Hahnel, Henri Wichmann, Swetlana Rot, Matthias Kappler, Matthias Bache and Dirk Vordermark

    Citation: BMC Cancer 2010 10:605

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  35. Content type: Research article

    Very low density lipoprotein receptor (VLDLR) has been considered as a multiple function receptor due to binding numerous ligands, causing endocytosis and regulating cellular signaling. Our group previously re...

    Authors: Lei He, Yanjun Lu, Peng Wang, Jun Zhang, Chuanchang Yin and Shen Qu

    Citation: BMC Cancer 2010 10:601

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  36. Content type: Research article

    Lung cancer causes the highest rate of cancer-related deaths both in men and women. As many current treatment modalities are inadequate in increasing patient survival, new therapeutic strategies are required. ...

    Authors: Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith and Salih Sanlioglu

    Citation: BMC Cancer 2010 10:584

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  37. Content type: Research article

    Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng and Zhao-You Tang

    Citation: BMC Cancer 2010 10:580

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  38. Content type: Research article

    The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα.

    Authors: Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi and Yoshinori Otsuki

    Citation: BMC Cancer 2010 10:566

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  39. Content type: Research article

    Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphobl...

    Authors: Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund and Christian Junghanss

    Citation: BMC Cancer 2010 10:560

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  40. Content type: Research article

    Combining MEK inhibitors with other signalling pathway inhibitors or conventional cytotoxic drugs represents a promising new strategy against cancer. RDEA119/BAY 869766 is a highly potent and selective MEK1/2 ...

    Authors: Qing Chang, Mark S Chapman, Jeffrey N Miner and David W Hedley

    Citation: BMC Cancer 2010 10:515

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  41. Content type: Research article

    Tumour growth and metastatic infiltration are favoured by several components of the tumour microenvironment. Bone marrow-derived multipotent mesenchymal stromal cells (MSC) are known to contribute to the tumou...

    Authors: Pascal-David Johann, Martin Vaegler, Friederike Gieseke, Philippa Mang, Sorin Armeanu-Ebinger, Torsten Kluba, Rupert Handgretinger and Ingo Müller

    Citation: BMC Cancer 2010 10:501

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  42. Content type: Research article

    An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. In endometrial adenocarcinoma F-prostanoid (FP) receptor expression is ...

    Authors: Margaret C Keightley, Kurt J Sales and Henry N Jabbour

    Citation: BMC Cancer 2010 10:488

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  43. Content type: Research article

    17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Lukas H Margaritis and Gerassimos E Voutsinas

    Citation: BMC Cancer 2010 10:481

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  44. Content type: Research article

    Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation...

    Authors: Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley and Dean A Fennell

    Citation: BMC Cancer 2010 10:380

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  45. Content type: Research article

    Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phe...

    Authors: Helen J Knowles, Karl-Ludwig Schaefer, Uta Dirksen and Nicholas A Athanasou

    Citation: BMC Cancer 2010 10:372

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